ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lymphangiogenesis (GO:0001946)	3.97930175
2	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.76077914
3	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.76077914
4	regulation of translation, ncRNA-mediated (GO:0045974)	3.76077914
5	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.30548368
6	behavioral response to nicotine (GO:0035095)	3.20374071
7	artery development (GO:0060840)	3.19154888
8	regulation of sarcomere organization (GO:0060297)	3.12349191
9	kidney morphogenesis (GO:0060993)	3.11838285
10	forebrain neuron differentiation (GO:0021879)	2.98347595
11	establishment of nucleus localization (GO:0040023)	2.91001420
12	negative regulation of Rho protein signal transduction (GO:0035024)	2.89670205
13	nucleus localization (GO:0051647)	2.81912318
14	limb development (GO:0060173)	2.79512319
15	appendage development (GO:0048736)	2.79512319
16	hindbrain development (GO:0030902)	2.78953510
17	pyrimidine nucleobase catabolic process (GO:0006208)	2.77789957
18	interkinetic nuclear migration (GO:0022027)	2.76500714
19	establishment of protein localization to Golgi (GO:0072600)	2.73639443
20	limb bud formation (GO:0060174)	2.72665117
21	nonmotile primary cilium assembly (GO:0035058)	2.71643115
22	somite development (GO:0061053)	2.70188233
23	blood vessel maturation (GO:0001955)	2.68834276
24	retinal ganglion cell axon guidance (GO:0031290)	2.64744359
25	regulation of hippo signaling (GO:0035330)	2.62221019
26	inner ear receptor stereocilium organization (GO:0060122)	2.61916362
27	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.58972110
28	histone H3-K4 trimethylation (GO:0080182)	2.58829318
29	neural tube formation (GO:0001841)	2.55572827
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.55148909
31	otic vesicle formation (GO:0030916)	2.53128974
32	startle response (GO:0001964)	2.52532256
33	regulation of axon guidance (GO:1902667)	2.51016787
34	cellular response to sterol (GO:0036315)	2.49560905
35	presynaptic membrane assembly (GO:0097105)	2.49375625
36	dendritic spine morphogenesis (GO:0060997)	2.48705091
37	cAMP catabolic process (GO:0006198)	2.46642733
38	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.46398077
39	protein K11-linked deubiquitination (GO:0035871)	2.46125700
40	dorsal/ventral axis specification (GO:0009950)	2.45879063
41	axonal fasciculation (GO:0007413)	2.40546075
42	regulation of axon extension involved in axon guidance (GO:0048841)	2.40121794
43	cardiac myofibril assembly (GO:0055003)	2.36663404
44	behavioral response to ethanol (GO:0048149)	2.35155413
45	positive regulation of gastrulation (GO:2000543)	2.34661888
46	auditory behavior (GO:0031223)	2.34510847
47	reflex (GO:0060004)	2.33550501
48	regulation of timing of cell differentiation (GO:0048505)	2.33441998
49	cyclic nucleotide catabolic process (GO:0009214)	2.33426449
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.32320406
51	spinal cord motor neuron differentiation (GO:0021522)	2.31356551
52	cornea development in camera-type eye (GO:0061303)	2.31169483
53	presynaptic membrane organization (GO:0097090)	2.30908001
54	myofibril assembly (GO:0030239)	2.29327426
55	central nervous system projection neuron axonogenesis (GO:0021952)	2.28580704
56	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.27622396
57	protein targeting to Golgi (GO:0000042)	2.27576893
58	nephron epithelium morphogenesis (GO:0072088)	2.26646257
59	nephron tubule morphogenesis (GO:0072078)	2.26646257
60	negative regulation of axon guidance (GO:1902668)	2.26309791
61	spinal cord development (GO:0021510)	2.26212478
62	vocalization behavior (GO:0071625)	2.26105363
63	central nervous system neuron axonogenesis (GO:0021955)	2.25578913
64	neuronal stem cell maintenance (GO:0097150)	2.24979353
65	regulation of hexokinase activity (GO:1903299)	2.23767014
66	regulation of glucokinase activity (GO:0033131)	2.23767014
67	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.23303604
68	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.23007892
69	renal tubule morphogenesis (GO:0061333)	2.22236851
70	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.21907677
71	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.21537055
72	activin receptor signaling pathway (GO:0032924)	2.20842948
73	pericardium development (GO:0060039)	2.20328790
74	prenylation (GO:0097354)	2.19733264
75	protein prenylation (GO:0018342)	2.19733264
76	smoothened signaling pathway (GO:0007224)	2.17886253
77	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.17063897
78	negative chemotaxis (GO:0050919)	2.16065986
79	cerebral cortex radially oriented cell migration (GO:0021799)	2.15668686
80	transmission of nerve impulse (GO:0019226)	2.15034173
81	olfactory bulb development (GO:0021772)	2.14990583
82	cilium morphogenesis (GO:0060271)	2.14500152
83	atrial cardiac muscle cell action potential (GO:0086014)	2.14111921
84	regulation of energy homeostasis (GO:2000505)	2.13130774
85	embryonic foregut morphogenesis (GO:0048617)	2.13008900
86	axon extension involved in axon guidance (GO:0048846)	2.10203519
87	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.10203519
88	synapse assembly (GO:0007416)	2.08176865
89	auditory receptor cell stereocilium organization (GO:0060088)	2.07175787
90	monoubiquitinated protein deubiquitination (GO:0035520)	2.06121098
91	regulation of sequestering of triglyceride (GO:0010889)	2.06011294
92	retina layer formation (GO:0010842)	2.05998530
93	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.05110419
94	neuron recognition (GO:0008038)	2.05020630
95	head development (GO:0060322)	2.04106503
96	nucleobase catabolic process (GO:0046113)	2.02793255
97	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.02661027
98	negative regulation of cAMP-mediated signaling (GO:0043951)	2.02594913
99	cytoplasmic mRNA processing body assembly (GO:0033962)	2.01978421
100	type B pancreatic cell development (GO:0003323)	2.01692226

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.00249446
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.16192203
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.86916358
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69463885
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40959688
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22971197
7	VDR_22108803_ChIP-Seq_LS180_Human	2.02624534
8	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.00331750
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98010894
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96314873
11	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.96092313
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.94381884
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.93811623
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92121063
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91100276
16	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.90491875
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88992163
18	P300_19829295_ChIP-Seq_ESCs_Human	1.88827015
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.73846016
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71769313
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.70787751
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.70161356
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.67807365
24	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.67468114
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.66722300
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.66187164
27	FUS_26573619_Chip-Seq_HEK293_Human	1.65540181
28	STAT3_23295773_ChIP-Seq_U87_Human	1.61926423
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59268093
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59268093
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.55632093
32	EWS_26573619_Chip-Seq_HEK293_Human	1.53515311
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.52390278
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52200275
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.50664391
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49616738
37	DROSHA_22980978_ChIP-Seq_HELA_Human	1.49388143
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49386189
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48285775
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.47687727
41	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47342596
42	TCF4_23295773_ChIP-Seq_U87_Human	1.46589518
43	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.46483601
44	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.46140359
45	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44771995
46	AHR_22903824_ChIP-Seq_MCF-7_Human	1.44517648
47	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.44473001
48	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.43879017
49	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42245420
50	TP53_16413492_ChIP-PET_HCT116_Human	1.41795403
51	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.41759116
52	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39528285
53	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.38584979
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36410337
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36310716
56	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35955527
57	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.35407350
58	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.35223405
59	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.35223405
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35211615
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.35126085
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33898691
63	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31175018
64	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.29581085
65	AR_25329375_ChIP-Seq_VCAP_Human	1.28381373
66	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28305698
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.27000347
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.24130732
69	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.23071407
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22905847
71	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22423048
72	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21122052
73	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.19139120
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.19125965
75	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17498619
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17435180
77	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16273348
78	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.16245817
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14212317
80	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.13827818
81	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13641577
82	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12241468
83	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.12007887
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11926416
85	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11484104
86	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.10773515
87	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.09856890
88	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.09617080
89	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.09583698
90	TCF4_22108803_ChIP-Seq_LS180_Human	1.09001002
91	KDM2B_26808549_Chip-Seq_REH_Human	1.08797324
92	* CBP_20019798_ChIP-Seq_JUKART_Human	1.08766863
93	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08766863
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.08766219
95	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.08478533
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08277081
97	* AR_19668381_ChIP-Seq_PC3_Human	1.06818147
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05776771
99	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.05008049
100	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.04396586

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	2.37901776
2	MP0010368_abnormal_lymphatic_system	2.37260611
3	MP0001879_abnormal_lymphatic_vessel	2.20204376
4	MP0003646_muscle_fatigue	2.12772661
5	MP0000569_abnormal_digit_pigmentation	2.11227315
6	MP0002102_abnormal_ear_morphology	1.99957842
7	MP0004885_abnormal_endolymph	1.94799294
8	MP0004133_heterotaxia	1.94539878
9	MP0005503_abnormal_tendon_morphology	1.94262598
10	MP0003890_abnormal_embryonic-extraembry	1.90799634
11	MP0002938_white_spotting	1.83026181
12	MP0001984_abnormal_olfaction	1.81312329
13	MP0000778_abnormal_nervous_system	1.80184950
14	MP0004145_abnormal_muscle_electrophysio	1.79581640
15	MP0003136_yellow_coat_color	1.79408455
16	MP0010030_abnormal_orbit_morphology	1.77467702
17	MP0002638_abnormal_pupillary_reflex	1.75960049
18	MP0003283_abnormal_digestive_organ	1.71469204
19	MP0003787_abnormal_imprinting	1.70968594
20	MP0000631_abnormal_neuroendocrine_gland	1.63394563
21	MP0006276_abnormal_autonomic_nervous	1.61280582
22	MP0002928_abnormal_bile_duct	1.57433428
23	MP0003878_abnormal_ear_physiology	1.53478841
24	MP0005377_hearing/vestibular/ear_phenot	1.53478841
25	MP0004272_abnormal_basement_membrane	1.49147375
26	MP0008877_abnormal_DNA_methylation	1.47953089
27	MP0002108_abnormal_muscle_morphology	1.44896020
28	MP0005551_abnormal_eye_electrophysiolog	1.44690098
29	MP0001502_abnormal_circadian_rhythm	1.30256331
30	MP0001486_abnormal_startle_reflex	1.27884054
31	MP0005646_abnormal_pituitary_gland	1.27856133
32	MP0004142_abnormal_muscle_tone	1.27543533
33	MP0003937_abnormal_limbs/digits/tail_de	1.25907722
34	MP0000566_synostosis	1.25487055
35	MP0005275_abnormal_skin_tensile	1.24264321
36	MP0000049_abnormal_middle_ear	1.23433465
37	MP0003119_abnormal_digestive_system	1.23048483
38	MP0009046_muscle_twitch	1.22598950
39	MP0004084_abnormal_cardiac_muscle	1.21972022
40	MP0004130_abnormal_muscle_cell	1.21654627
41	MP0001299_abnormal_eye_distance/	1.14913289
42	MP0003755_abnormal_palate_morphology	1.13971594
43	MP0003122_maternal_imprinting	1.12497663
44	MP0003935_abnormal_craniofacial_develop	1.08211701
45	MP0005423_abnormal_somatic_nervous	1.06247162
46	MP0005253_abnormal_eye_physiology	1.05311555
47	MP0005167_abnormal_blood-brain_barrier	1.05298114
48	MP0006072_abnormal_retinal_apoptosis	1.05183446
49	MP0003942_abnormal_urinary_system	1.04933920
50	MP0000026_abnormal_inner_ear	1.04906967
51	MP0005257_abnormal_intraocular_pressure	1.03719832
52	MP0002272_abnormal_nervous_system	1.02246958
53	MP0005386_behavior/neurological_phenoty	1.02176348
54	MP0004924_abnormal_behavior	1.02176348
55	MP0005187_abnormal_penis_morphology	1.01135115
56	MP0003121_genomic_imprinting	1.00732577
57	MP0005409_darkened_coat_color	0.99321978
58	MP0008961_abnormal_basal_metabolism	0.98931239
59	MP0008775_abnormal_heart_ventricle	0.98436432
60	MP0004085_abnormal_heartbeat	0.98434390
61	MP0002572_abnormal_emotion/affect_behav	0.98262306
62	MP0000013_abnormal_adipose_tissue	0.98189128
63	MP0004036_abnormal_muscle_relaxation	0.98134913
64	MP0005620_abnormal_muscle_contractility	0.97179155
65	MP0005670_abnormal_white_adipose	0.96308833
66	MP0002127_abnormal_cardiovascular_syste	0.96090417
67	MP0006138_congestive_heart_failure	0.95170129
68	MP0001501_abnormal_sleep_pattern	0.95141350
69	MP0000955_abnormal_spinal_cord	0.94433358
70	MP0001286_abnormal_eye_development	0.93576692
71	MP0002557_abnormal_social/conspecific_i	0.93574600
72	MP0002254_reproductive_system_inflammat	0.93532128
73	MP0002184_abnormal_innervation	0.93241914
74	MP0005595_abnormal_vascular_smooth	0.92539309
75	MP0003279_aneurysm	0.91735309
76	MP0000767_abnormal_smooth_muscle	0.91623182
77	MP0009250_abnormal_appendicular_skeleto	0.90189863
78	MP0002067_abnormal_sensory_capabilities	0.89915578
79	MP0004742_abnormal_vestibular_system	0.89301138
80	MP0003385_abnormal_body_wall	0.88705777
81	MP0004215_abnormal_myocardial_fiber	0.88191169
82	MP0002752_abnormal_somatic_nervous	0.87402039
83	MP0002876_abnormal_thyroid_physiology	0.87189403
84	MP0000534_abnormal_ureter_morphology	0.86820496
85	MP0009745_abnormal_behavioral_response	0.86412764
86	MP0000428_abnormal_craniofacial_morphol	0.86213161
87	MP0002138_abnormal_hepatobiliary_system	0.84338579
88	MP0003938_abnormal_ear_development	0.84201879
89	MP0005195_abnormal_posterior_eye	0.83602282
90	MP0003635_abnormal_synaptic_transmissio	0.82680326
91	MP0002116_abnormal_craniofacial_bone	0.82604237
92	MP0002249_abnormal_larynx_morphology	0.82516654
93	MP0002932_abnormal_joint_morphology	0.82464301
94	MP0003861_abnormal_nervous_system	0.81762172
95	MP0001968_abnormal_touch/_nociception	0.81665839
96	MP0000383_abnormal_hair_follicle	0.81002086
97	MP0003880_abnormal_central_pattern	0.80856134
98	MP0002063_abnormal_learning/memory/cond	0.80785842
99	MP0001485_abnormal_pinna_reflex	0.80092340
100	MP0005391_vision/eye_phenotype	0.79810497

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	3.34121032
2	Genetic anticipation (HP:0003743)	2.97917638
3	Abnormality of the ischium (HP:0003174)	2.87886264
4	Nephronophthisis (HP:0000090)	2.86034477
5	Hypoplastic ischia (HP:0003175)	2.82020600
6	Abnormality of the renal medulla (HP:0100957)	2.76463189
7	Pancreatic cysts (HP:0001737)	2.73025536
8	Broad-based gait (HP:0002136)	2.67324277
9	Pancreatic fibrosis (HP:0100732)	2.63319271
10	Tubular atrophy (HP:0000092)	2.53325847
11	Abnormality of midbrain morphology (HP:0002418)	2.51736027
12	Molar tooth sign on MRI (HP:0002419)	2.51736027
13	Broad metatarsal (HP:0001783)	2.41961206
14	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.36660591
15	Congenital stationary night blindness (HP:0007642)	2.35747172
16	Abnormality of the renal cortex (HP:0011035)	2.30885104
17	Type II lissencephaly (HP:0007260)	2.29751517
18	Keratoconus (HP:0000563)	2.26414632
19	Increased corneal curvature (HP:0100692)	2.26414632
20	Progressive cerebellar ataxia (HP:0002073)	2.25133346
21	True hermaphroditism (HP:0010459)	2.24421617
22	Bulbous nose (HP:0000414)	2.16984813
23	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.16080942
24	Short 4th metacarpal (HP:0010044)	2.16080942
25	Limited hip movement (HP:0008800)	2.15587029
26	Hip contracture (HP:0003273)	2.13714361
27	Abnormality of the nasal septum (HP:0000419)	2.12704998
28	Medial flaring of the eyebrow (HP:0010747)	2.12296152
29	Optic nerve hypoplasia (HP:0000609)	2.11564143
30	Attenuation of retinal blood vessels (HP:0007843)	2.09776466
31	Abnormality of the aortic arch (HP:0012303)	2.08630585
32	Gaze-evoked nystagmus (HP:0000640)	2.08117968
33	Large for gestational age (HP:0001520)	2.03326729
34	Cystic liver disease (HP:0006706)	2.02701504
35	Narrow palate (HP:0000189)	2.02408933
36	Preaxial foot polydactyly (HP:0001841)	2.01404489
37	Chronic hepatic failure (HP:0100626)	1.99538603
38	Midline defect of the nose (HP:0004122)	1.99391245
39	Genital tract atresia (HP:0001827)	1.96379239
40	Hemiparesis (HP:0001269)	1.95915270
41	Protruding tongue (HP:0010808)	1.95859665
42	Shawl scrotum (HP:0000049)	1.93921714
43	Febrile seizures (HP:0002373)	1.90425861
44	Abnormal pancreas size (HP:0012094)	1.88276505
45	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87983032
46	Wrist flexion contracture (HP:0001239)	1.87690134
47	Vaginal atresia (HP:0000148)	1.87129233
48	Decreased circulating renin level (HP:0003351)	1.86451739
49	Calf muscle hypertrophy (HP:0008981)	1.86101263
50	Fair hair (HP:0002286)	1.85840431
51	Exotropia (HP:0000577)	1.84965780
52	Abnormality of the pubic bones (HP:0003172)	1.83919541
53	Cutaneous finger syndactyly (HP:0010554)	1.83756159
54	Hyperkalemia (HP:0002153)	1.83287843
55	Polydipsia (HP:0001959)	1.82730753
56	Abnormal drinking behavior (HP:0030082)	1.82730753
57	Gait imbalance (HP:0002141)	1.82687542
58	Morphological abnormality of the middle ear (HP:0008609)	1.80516644
59	Hypoplasia of the maxilla (HP:0000327)	1.79392708
60	Prolonged QT interval (HP:0001657)	1.77276448
61	Cerebellar dysplasia (HP:0007033)	1.75053466
62	Short foot (HP:0001773)	1.74196694
63	Muscle hypertrophy of the lower extremities (HP:0008968)	1.73619857
64	Hematochezia (HP:0002573)	1.73564799
65	Overgrowth (HP:0001548)	1.73195172
66	Abnormality of incisor morphology (HP:0011063)	1.72572702
67	Septo-optic dysplasia (HP:0100842)	1.71542986
68	Widely spaced teeth (HP:0000687)	1.71119931
69	Poor coordination (HP:0002370)	1.71065859
70	Congenital primary aphakia (HP:0007707)	1.70703753
71	Shallow orbits (HP:0000586)	1.70664496
72	Hypoplastic iliac wings (HP:0002866)	1.67612807
73	Short hallux (HP:0010109)	1.66668250
74	Oligodactyly (hands) (HP:0001180)	1.65705845
75	Hypoplastic labia majora (HP:0000059)	1.65420139
76	Aplasia/Hypoplasia of the lens (HP:0008063)	1.65124348
77	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.64585705
78	Hypothermia (HP:0002045)	1.63895410
79	Neoplasm of the heart (HP:0100544)	1.63741948
80	Hypoplastic nipples (HP:0002557)	1.63167055
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.62830648
82	Anophthalmia (HP:0000528)	1.61922905
83	Neoplasm of the oral cavity (HP:0100649)	1.61738798
84	Bronchomalacia (HP:0002780)	1.61296955
85	Absent speech (HP:0001344)	1.60303675
86	Intestinal atresia (HP:0011100)	1.57783219
87	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.56899614
88	Abnormal hair whorl (HP:0010721)	1.56778683
89	Duplicated collecting system (HP:0000081)	1.56611646
90	Bilateral microphthalmos (HP:0007633)	1.56278586
91	Nephrogenic diabetes insipidus (HP:0009806)	1.56209252
92	Tubulointerstitial abnormality (HP:0001969)	1.56207304
93	Congenital hepatic fibrosis (HP:0002612)	1.55546103
94	2-3 toe syndactyly (HP:0004691)	1.55138325
95	Abnormality of the labia majora (HP:0012881)	1.52191973
96	Potter facies (HP:0002009)	1.51671419
97	Facial shape deformation (HP:0011334)	1.51671419
98	Cupped ear (HP:0000378)	1.51574436
99	Tubulointerstitial fibrosis (HP:0005576)	1.51397021
100	Highly arched eyebrow (HP:0002553)	1.51102568

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.55649318
2	TIE1	3.57403982
3	BMPR1B	3.15892877
4	CASK	2.77829533
5	PNCK	2.40730936
6	LATS1	2.30845556
7	FGFR2	2.20192821
8	MARK1	2.02624612
9	WNK3	1.88769673
10	CAMK1G	1.88668443
11	MAP3K4	1.77241571
12	TNIK	1.75608762
13	STK38L	1.73303290
14	MAPK13	1.64421144
15	INSRR	1.61229303
16	CAMK1D	1.60285644
17	NLK	1.54770244
18	TGFBR1	1.49186787
19	TAOK3	1.48219428
20	EPHB2	1.44333244
21	MAPK15	1.43388906
22	NTRK2	1.41074644
23	OBSCN	1.40946770
24	PINK1	1.40276943
25	SGK2	1.28878658
26	AKT3	1.24932824
27	NTRK3	1.24204122
28	MAP4K2	1.23201267
29	STK39	1.20629490
30	GRK1	1.19682821
31	MAP3K7	1.19312722
32	PTK2B	1.13001722
33	SGK494	1.09030683
34	SGK223	1.09030683
35	FER	1.08562576
36	PAK3	1.06909753
37	WNK4	1.03951948
38	TYRO3	1.02222304
39	NUAK1	1.00523450
40	WNK1	1.00522444
41	TRPM7	0.98124644
42	PRKAA2	0.94544142
43	ACVR1B	0.92954870
44	STK3	0.92870753
45	PHKG2	0.91491064
46	PHKG1	0.91491064
47	EPHA3	0.90843324
48	PRKAA1	0.88972040
49	STK11	0.87668192
50	ADRBK2	0.84053246
51	PKN1	0.83882080
52	OXSR1	0.83612188
53	PRKCE	0.82240929
54	MAP3K9	0.79136297
55	CAMK1	0.78951016
56	ADRBK1	0.78487186
57	EPHA4	0.73660798
58	PASK	0.73246804
59	MARK2	0.72481512
60	MYLK	0.72434544
61	PDGFRB	0.69421045
62	DYRK2	0.67478442
63	PIK3CA	0.67297011
64	STK38	0.65947621
65	MAPK7	0.65925597
66	PRKCH	0.64496792
67	SGK3	0.62844087
68	MAP2K4	0.59735837
69	DAPK2	0.59517404
70	CAMK4	0.59499914
71	IRAK1	0.58622010
72	PRKG1	0.57969261
73	CDK3	0.57797086
74	TGFBR2	0.56954652
75	PRKCG	0.56335332
76	BRD4	0.55647167
77	DYRK1A	0.54011534
78	TEC	0.52627722
79	PIK3CG	0.52485732
80	SIK2	0.52228047
81	MELK	0.50107356
82	EEF2K	0.49979237
83	FGFR1	0.49559066
84	MKNK2	0.48504989
85	ZAK	0.48379337
86	FGFR3	0.47785471
87	HIPK2	0.47399570
88	ERBB3	0.47252662
89	TNK2	0.47156058
90	ROCK1	0.44520633
91	MTOR	0.43879219
92	MAPK12	0.43142123
93	ERBB2	0.42580814
94	CAMK2A	0.42066301
95	DYRK1B	0.41360481
96	DYRK3	0.40813857
97	CDK12	0.40640577
98	MUSK	0.40284090
99	SGK1	0.38492085
100	PRKD2	0.34676924

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Circadian rhythm_Homo sapiens_hsa04710	2.54412211
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.33779287
3	Phototransduction_Homo sapiens_hsa04744	2.06408087
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.95720683
5	Nicotine addiction_Homo sapiens_hsa05033	1.87386950
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.85903957
7	Basal cell carcinoma_Homo sapiens_hsa05217	1.84326505
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.80241972
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.77658982
10	Insulin secretion_Homo sapiens_hsa04911	1.72914736
11	Lysine degradation_Homo sapiens_hsa00310	1.70482140
12	Taste transduction_Homo sapiens_hsa04742	1.69212103
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68515051
14	Morphine addiction_Homo sapiens_hsa05032	1.61847607
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.59633686
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56418202
17	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.54264538
18	ECM-receptor interaction_Homo sapiens_hsa04512	1.52298203
19	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.51801833
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.51705948
21	Circadian entrainment_Homo sapiens_hsa04713	1.51147391
22	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.50732613
23	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.47290006
24	Axon guidance_Homo sapiens_hsa04360	1.42325156
25	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.41031030
26	Butanoate metabolism_Homo sapiens_hsa00650	1.40206536
27	GABAergic synapse_Homo sapiens_hsa04727	1.37942190
28	ABC transporters_Homo sapiens_hsa02010	1.34689381
29	Serotonergic synapse_Homo sapiens_hsa04726	1.34207656
30	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.32189634
31	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.29589626
32	Hippo signaling pathway_Homo sapiens_hsa04390	1.28850474
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28776361
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25886903
35	Regulation of autophagy_Homo sapiens_hsa04140	1.14796710
36	Adherens junction_Homo sapiens_hsa04520	1.10325188
37	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.10313751
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08063069
39	Ras signaling pathway_Homo sapiens_hsa04014	1.06863198
40	Cholinergic synapse_Homo sapiens_hsa04725	1.05602235
41	Protein digestion and absorption_Homo sapiens_hsa04974	1.04300519
42	Dopaminergic synapse_Homo sapiens_hsa04728	1.04097199
43	cAMP signaling pathway_Homo sapiens_hsa04024	1.03533809
44	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.01084306
45	Focal adhesion_Homo sapiens_hsa04510	1.01046885
46	Calcium signaling pathway_Homo sapiens_hsa04020	1.01034284
47	Wnt signaling pathway_Homo sapiens_hsa04310	1.00384434
48	Notch signaling pathway_Homo sapiens_hsa04330	0.99459089
49	Basal transcription factors_Homo sapiens_hsa03022	0.98797780
50	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.97294841
51	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.97011882
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.96745475
53	Tight junction_Homo sapiens_hsa04530	0.96000804
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.95981034
55	Long-term depression_Homo sapiens_hsa04730	0.95288456
56	FoxO signaling pathway_Homo sapiens_hsa04068	0.94932990
57	Olfactory transduction_Homo sapiens_hsa04740	0.94359997
58	Cocaine addiction_Homo sapiens_hsa05030	0.93493678
59	Melanogenesis_Homo sapiens_hsa04916	0.88579164
60	MAPK signaling pathway_Homo sapiens_hsa04010	0.87557974
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86400866
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.82334966
63	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.82236550
64	Salivary secretion_Homo sapiens_hsa04970	0.78674571
65	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.76695496
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.76492761
67	Rap1 signaling pathway_Homo sapiens_hsa04015	0.75960166
68	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75783364
69	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.75241308
70	Renin secretion_Homo sapiens_hsa04924	0.74685526
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.73763463
72	Choline metabolism in cancer_Homo sapiens_hsa05231	0.73378186
73	Pathways in cancer_Homo sapiens_hsa05200	0.72726672
74	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.70611379
75	Renal cell carcinoma_Homo sapiens_hsa05211	0.70533571
76	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.70161378
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.69650015
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69415286
79	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.68118019
80	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.66444649
81	Gastric acid secretion_Homo sapiens_hsa04971	0.65679604
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.62969115
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.61721525
84	AMPK signaling pathway_Homo sapiens_hsa04152	0.61511749
85	Propanoate metabolism_Homo sapiens_hsa00640	0.61424418
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61298096
87	MicroRNAs in cancer_Homo sapiens_hsa05206	0.59961909
88	Amphetamine addiction_Homo sapiens_hsa05031	0.58856466
89	Bile secretion_Homo sapiens_hsa04976	0.58147468
90	GnRH signaling pathway_Homo sapiens_hsa04912	0.56859789
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55401688
92	Melanoma_Homo sapiens_hsa05218	0.54012387
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53408028
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.53319788
95	Pancreatic secretion_Homo sapiens_hsa04972	0.52499338
96	Prostate cancer_Homo sapiens_hsa05215	0.52125966
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.52095243
98	Estrogen signaling pathway_Homo sapiens_hsa04915	0.50887292
99	RNA degradation_Homo sapiens_hsa03018	0.50668796
100	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.50563392

KIAA0355

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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