KIAA0355

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymphangiogenesis (GO:0001946)3.97930175
2negative regulation of translation, ncRNA-mediated (GO:0040033)3.76077914
3regulation of translation, ncRNA-mediated (GO:0045974)3.76077914
4negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.76077914
5negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30548368
6behavioral response to nicotine (GO:0035095)3.20374071
7artery development (GO:0060840)3.19154888
8regulation of sarcomere organization (GO:0060297)3.12349191
9kidney morphogenesis (GO:0060993)3.11838285
10forebrain neuron differentiation (GO:0021879)2.98347595
11establishment of nucleus localization (GO:0040023)2.91001420
12negative regulation of Rho protein signal transduction (GO:0035024)2.89670205
13nucleus localization (GO:0051647)2.81912318
14appendage development (GO:0048736)2.79512319
15limb development (GO:0060173)2.79512319
16hindbrain development (GO:0030902)2.78953510
17pyrimidine nucleobase catabolic process (GO:0006208)2.77789957
18interkinetic nuclear migration (GO:0022027)2.76500714
19establishment of protein localization to Golgi (GO:0072600)2.73639443
20limb bud formation (GO:0060174)2.72665117
21nonmotile primary cilium assembly (GO:0035058)2.71643115
22somite development (GO:0061053)2.70188233
23blood vessel maturation (GO:0001955)2.68834276
24retinal ganglion cell axon guidance (GO:0031290)2.64744359
25regulation of hippo signaling (GO:0035330)2.62221019
26inner ear receptor stereocilium organization (GO:0060122)2.61916362
27embryonic retina morphogenesis in camera-type eye (GO:0060059)2.58972110
28histone H3-K4 trimethylation (GO:0080182)2.58829318
29neural tube formation (GO:0001841)2.55572827
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55148909
31otic vesicle formation (GO:0030916)2.53128974
32startle response (GO:0001964)2.52532256
33regulation of axon guidance (GO:1902667)2.51016787
34cellular response to sterol (GO:0036315)2.49560905
35presynaptic membrane assembly (GO:0097105)2.49375625
36dendritic spine morphogenesis (GO:0060997)2.48705091
37cAMP catabolic process (GO:0006198)2.46642733
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46398077
39protein K11-linked deubiquitination (GO:0035871)2.46125700
40dorsal/ventral axis specification (GO:0009950)2.45879063
41axonal fasciculation (GO:0007413)2.40546075
42regulation of axon extension involved in axon guidance (GO:0048841)2.40121794
43cardiac myofibril assembly (GO:0055003)2.36663404
44behavioral response to ethanol (GO:0048149)2.35155413
45positive regulation of gastrulation (GO:2000543)2.34661888
46auditory behavior (GO:0031223)2.34510847
47reflex (GO:0060004)2.33550501
48regulation of timing of cell differentiation (GO:0048505)2.33441998
49cyclic nucleotide catabolic process (GO:0009214)2.33426449
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.32320406
51spinal cord motor neuron differentiation (GO:0021522)2.31356551
52cornea development in camera-type eye (GO:0061303)2.31169483
53presynaptic membrane organization (GO:0097090)2.30908001
54myofibril assembly (GO:0030239)2.29327426
55central nervous system projection neuron axonogenesis (GO:0021952)2.28580704
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.27622396
57protein targeting to Golgi (GO:0000042)2.27576893
58nephron tubule morphogenesis (GO:0072078)2.26646257
59nephron epithelium morphogenesis (GO:0072088)2.26646257
60negative regulation of axon guidance (GO:1902668)2.26309791
61spinal cord development (GO:0021510)2.26212478
62vocalization behavior (GO:0071625)2.26105363
63central nervous system neuron axonogenesis (GO:0021955)2.25578913
64neuronal stem cell maintenance (GO:0097150)2.24979353
65regulation of glucokinase activity (GO:0033131)2.23767014
66regulation of hexokinase activity (GO:1903299)2.23767014
67neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.23303604
68retrograde transport, vesicle recycling within Golgi (GO:0000301)2.23007892
69renal tubule morphogenesis (GO:0061333)2.22236851
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21907677
71regulation of non-canonical Wnt signaling pathway (GO:2000050)2.21537055
72activin receptor signaling pathway (GO:0032924)2.20842948
73pericardium development (GO:0060039)2.20328790
74protein prenylation (GO:0018342)2.19733264
75prenylation (GO:0097354)2.19733264
76smoothened signaling pathway (GO:0007224)2.17886253
77positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.17063897
78negative chemotaxis (GO:0050919)2.16065986
79cerebral cortex radially oriented cell migration (GO:0021799)2.15668686
80transmission of nerve impulse (GO:0019226)2.15034173
81olfactory bulb development (GO:0021772)2.14990583
82cilium morphogenesis (GO:0060271)2.14500152
83atrial cardiac muscle cell action potential (GO:0086014)2.14111921
84regulation of energy homeostasis (GO:2000505)2.13130774
85embryonic foregut morphogenesis (GO:0048617)2.13008900
86neuron projection extension involved in neuron projection guidance (GO:1902284)2.10203519
87axon extension involved in axon guidance (GO:0048846)2.10203519
88synapse assembly (GO:0007416)2.08176865
89auditory receptor cell stereocilium organization (GO:0060088)2.07175787
90monoubiquitinated protein deubiquitination (GO:0035520)2.06121098
91regulation of sequestering of triglyceride (GO:0010889)2.06011294
92retina layer formation (GO:0010842)2.05998530
93positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.05110419
94neuron recognition (GO:0008038)2.05020630
95head development (GO:0060322)2.04106503
96nucleobase catabolic process (GO:0046113)2.02793255
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.02661027
98negative regulation of cAMP-mediated signaling (GO:0043951)2.02594913
99cytoplasmic mRNA processing body assembly (GO:0033962)2.01978421
100type B pancreatic cell development (GO:0003323)2.01692226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.00249446
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16192203
3GBX2_23144817_ChIP-Seq_PC3_Human2.86916358
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.69463885
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40959688
6ZNF274_21170338_ChIP-Seq_K562_Hela2.22971197
7VDR_22108803_ChIP-Seq_LS180_Human2.02624534
8PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00331750
9SALL1_21062744_ChIP-ChIP_HESCs_Human1.98010894
10POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96314873
11PIAS1_25552417_ChIP-Seq_VCAP_Human1.96092313
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94381884
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93811623
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92121063
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.91100276
16* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90491875
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88992163
18P300_19829295_ChIP-Seq_ESCs_Human1.88827015
19TAF15_26573619_Chip-Seq_HEK293_Human1.73846016
20SMAD4_21799915_ChIP-Seq_A2780_Human1.71769313
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70787751
22AR_21572438_ChIP-Seq_LNCaP_Human1.70161356
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.67807365
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67468114
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66722300
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66187164
27FUS_26573619_Chip-Seq_HEK293_Human1.65540181
28STAT3_23295773_ChIP-Seq_U87_Human1.61926423
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59268093
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59268093
31BCAT_22108803_ChIP-Seq_LS180_Human1.55632093
32EWS_26573619_Chip-Seq_HEK293_Human1.53515311
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52390278
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.52200275
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.50664391
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49616738
37DROSHA_22980978_ChIP-Seq_HELA_Human1.49388143
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49386189
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.48285775
40IGF1R_20145208_ChIP-Seq_DFB_Human1.47687727
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47342596
42TCF4_23295773_ChIP-Seq_U87_Human1.46589518
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46483601
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46140359
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44771995
46AHR_22903824_ChIP-Seq_MCF-7_Human1.44517648
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.44473001
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43879017
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42245420
50TP53_16413492_ChIP-PET_HCT116_Human1.41795403
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.41759116
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39528285
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.38584979
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36410337
55RNF2_27304074_Chip-Seq_NSC_Mouse1.36310716
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35955527
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35407350
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35223405
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35223405
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35211615
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35126085
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33898691
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31175018
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29581085
65AR_25329375_ChIP-Seq_VCAP_Human1.28381373
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28305698
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27000347
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24130732
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23071407
70RUNX2_22187159_ChIP-Seq_PCA_Human1.22905847
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22423048
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.21122052
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19139120
74ER_23166858_ChIP-Seq_MCF-7_Human1.19125965
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.17498619
76REST_21632747_ChIP-Seq_MESCs_Mouse1.17435180
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16273348
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16245817
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14212317
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.13827818
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13641577
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12241468
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12007887
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.11926416
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11484104
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10773515
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09856890
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09617080
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09583698
90TCF4_22108803_ChIP-Seq_LS180_Human1.09001002
91KDM2B_26808549_Chip-Seq_REH_Human1.08797324
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08766863
93* CBP_20019798_ChIP-Seq_JUKART_Human1.08766863
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.08766219
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08478533
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.08277081
97* AR_19668381_ChIP-Seq_PC3_Human1.06818147
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05776771
99SMAD4_21741376_ChIP-Seq_HESCs_Human1.05008049
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04396586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.37901776
2MP0010368_abnormal_lymphatic_system2.37260611
3MP0001879_abnormal_lymphatic_vessel2.20204376
4MP0003646_muscle_fatigue2.12772661
5MP0000569_abnormal_digit_pigmentation2.11227315
6MP0002102_abnormal_ear_morphology1.99957842
7MP0004885_abnormal_endolymph1.94799294
8MP0004133_heterotaxia1.94539878
9MP0005503_abnormal_tendon_morphology1.94262598
10MP0003890_abnormal_embryonic-extraembry1.90799634
11MP0002938_white_spotting1.83026181
12MP0001984_abnormal_olfaction1.81312329
13MP0000778_abnormal_nervous_system1.80184950
14MP0004145_abnormal_muscle_electrophysio1.79581640
15MP0003136_yellow_coat_color1.79408455
16MP0010030_abnormal_orbit_morphology1.77467702
17MP0002638_abnormal_pupillary_reflex1.75960049
18MP0003283_abnormal_digestive_organ1.71469204
19MP0003787_abnormal_imprinting1.70968594
20MP0000631_abnormal_neuroendocrine_gland1.63394563
21MP0006276_abnormal_autonomic_nervous1.61280582
22MP0002928_abnormal_bile_duct1.57433428
23MP0003878_abnormal_ear_physiology1.53478841
24MP0005377_hearing/vestibular/ear_phenot1.53478841
25MP0004272_abnormal_basement_membrane1.49147375
26MP0008877_abnormal_DNA_methylation1.47953089
27MP0002108_abnormal_muscle_morphology1.44896020
28MP0005551_abnormal_eye_electrophysiolog1.44690098
29MP0001502_abnormal_circadian_rhythm1.30256331
30MP0001486_abnormal_startle_reflex1.27884054
31MP0005646_abnormal_pituitary_gland1.27856133
32MP0004142_abnormal_muscle_tone1.27543533
33MP0003937_abnormal_limbs/digits/tail_de1.25907722
34MP0000566_synostosis1.25487055
35MP0005275_abnormal_skin_tensile1.24264321
36MP0000049_abnormal_middle_ear1.23433465
37MP0003119_abnormal_digestive_system1.23048483
38MP0009046_muscle_twitch1.22598950
39MP0004084_abnormal_cardiac_muscle1.21972022
40MP0004130_abnormal_muscle_cell1.21654627
41MP0001299_abnormal_eye_distance/1.14913289
42MP0003755_abnormal_palate_morphology1.13971594
43MP0003122_maternal_imprinting1.12497663
44MP0003935_abnormal_craniofacial_develop1.08211701
45MP0005423_abnormal_somatic_nervous1.06247162
46MP0005253_abnormal_eye_physiology1.05311555
47MP0005167_abnormal_blood-brain_barrier1.05298114
48MP0006072_abnormal_retinal_apoptosis1.05183446
49MP0003942_abnormal_urinary_system1.04933920
50MP0000026_abnormal_inner_ear1.04906967
51MP0005257_abnormal_intraocular_pressure1.03719832
52MP0002272_abnormal_nervous_system1.02246958
53MP0005386_behavior/neurological_phenoty1.02176348
54MP0004924_abnormal_behavior1.02176348
55MP0005187_abnormal_penis_morphology1.01135115
56MP0003121_genomic_imprinting1.00732577
57MP0005409_darkened_coat_color0.99321978
58MP0008961_abnormal_basal_metabolism0.98931239
59MP0008775_abnormal_heart_ventricle0.98436432
60MP0004085_abnormal_heartbeat0.98434390
61MP0002572_abnormal_emotion/affect_behav0.98262306
62MP0000013_abnormal_adipose_tissue0.98189128
63MP0004036_abnormal_muscle_relaxation0.98134913
64MP0005620_abnormal_muscle_contractility0.97179155
65MP0005670_abnormal_white_adipose0.96308833
66MP0002127_abnormal_cardiovascular_syste0.96090417
67MP0006138_congestive_heart_failure0.95170129
68MP0001501_abnormal_sleep_pattern0.95141350
69MP0000955_abnormal_spinal_cord0.94433358
70MP0001286_abnormal_eye_development0.93576692
71MP0002557_abnormal_social/conspecific_i0.93574600
72MP0002254_reproductive_system_inflammat0.93532128
73MP0002184_abnormal_innervation0.93241914
74MP0005595_abnormal_vascular_smooth0.92539309
75MP0003279_aneurysm0.91735309
76MP0000767_abnormal_smooth_muscle0.91623182
77MP0009250_abnormal_appendicular_skeleto0.90189863
78MP0002067_abnormal_sensory_capabilities0.89915578
79MP0004742_abnormal_vestibular_system0.89301138
80MP0003385_abnormal_body_wall0.88705777
81MP0004215_abnormal_myocardial_fiber0.88191169
82MP0002752_abnormal_somatic_nervous0.87402039
83MP0002876_abnormal_thyroid_physiology0.87189403
84MP0000534_abnormal_ureter_morphology0.86820496
85MP0009745_abnormal_behavioral_response0.86412764
86MP0000428_abnormal_craniofacial_morphol0.86213161
87MP0002138_abnormal_hepatobiliary_system0.84338579
88MP0003938_abnormal_ear_development0.84201879
89MP0005195_abnormal_posterior_eye0.83602282
90MP0003635_abnormal_synaptic_transmissio0.82680326
91MP0002116_abnormal_craniofacial_bone0.82604237
92MP0002249_abnormal_larynx_morphology0.82516654
93MP0002932_abnormal_joint_morphology0.82464301
94MP0003861_abnormal_nervous_system0.81762172
95MP0001968_abnormal_touch/_nociception0.81665839
96MP0000383_abnormal_hair_follicle0.81002086
97MP0003880_abnormal_central_pattern0.80856134
98MP0002063_abnormal_learning/memory/cond0.80785842
99MP0001485_abnormal_pinna_reflex0.80092340
100MP0005391_vision/eye_phenotype0.79810497

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.34121032
2Genetic anticipation (HP:0003743)2.97917638
3Abnormality of the ischium (HP:0003174)2.87886264
4Nephronophthisis (HP:0000090)2.86034477
5Hypoplastic ischia (HP:0003175)2.82020600
6Abnormality of the renal medulla (HP:0100957)2.76463189
7Pancreatic cysts (HP:0001737)2.73025536
8Broad-based gait (HP:0002136)2.67324277
9Pancreatic fibrosis (HP:0100732)2.63319271
10Tubular atrophy (HP:0000092)2.53325847
11Molar tooth sign on MRI (HP:0002419)2.51736027
12Abnormality of midbrain morphology (HP:0002418)2.51736027
13Broad metatarsal (HP:0001783)2.41961206
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36660591
15Congenital stationary night blindness (HP:0007642)2.35747172
16Abnormality of the renal cortex (HP:0011035)2.30885104
17Type II lissencephaly (HP:0007260)2.29751517
18Keratoconus (HP:0000563)2.26414632
19Increased corneal curvature (HP:0100692)2.26414632
20Progressive cerebellar ataxia (HP:0002073)2.25133346
21True hermaphroditism (HP:0010459)2.24421617
22Bulbous nose (HP:0000414)2.16984813
23Short 4th metacarpal (HP:0010044)2.16080942
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16080942
25Limited hip movement (HP:0008800)2.15587029
26Hip contracture (HP:0003273)2.13714361
27Abnormality of the nasal septum (HP:0000419)2.12704998
28Medial flaring of the eyebrow (HP:0010747)2.12296152
29Optic nerve hypoplasia (HP:0000609)2.11564143
30Attenuation of retinal blood vessels (HP:0007843)2.09776466
31Abnormality of the aortic arch (HP:0012303)2.08630585
32Gaze-evoked nystagmus (HP:0000640)2.08117968
33Large for gestational age (HP:0001520)2.03326729
34Cystic liver disease (HP:0006706)2.02701504
35Narrow palate (HP:0000189)2.02408933
36Preaxial foot polydactyly (HP:0001841)2.01404489
37Chronic hepatic failure (HP:0100626)1.99538603
38Midline defect of the nose (HP:0004122)1.99391245
39Genital tract atresia (HP:0001827)1.96379239
40Hemiparesis (HP:0001269)1.95915270
41Protruding tongue (HP:0010808)1.95859665
42Shawl scrotum (HP:0000049)1.93921714
43Febrile seizures (HP:0002373)1.90425861
44Abnormal pancreas size (HP:0012094)1.88276505
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87983032
46Wrist flexion contracture (HP:0001239)1.87690134
47Vaginal atresia (HP:0000148)1.87129233
48Decreased circulating renin level (HP:0003351)1.86451739
49Calf muscle hypertrophy (HP:0008981)1.86101263
50Fair hair (HP:0002286)1.85840431
51Exotropia (HP:0000577)1.84965780
52Abnormality of the pubic bones (HP:0003172)1.83919541
53Cutaneous finger syndactyly (HP:0010554)1.83756159
54Hyperkalemia (HP:0002153)1.83287843
55Abnormal drinking behavior (HP:0030082)1.82730753
56Polydipsia (HP:0001959)1.82730753
57Gait imbalance (HP:0002141)1.82687542
58Morphological abnormality of the middle ear (HP:0008609)1.80516644
59Hypoplasia of the maxilla (HP:0000327)1.79392708
60Prolonged QT interval (HP:0001657)1.77276448
61Cerebellar dysplasia (HP:0007033)1.75053466
62Short foot (HP:0001773)1.74196694
63Muscle hypertrophy of the lower extremities (HP:0008968)1.73619857
64Hematochezia (HP:0002573)1.73564799
65Overgrowth (HP:0001548)1.73195172
66Abnormality of incisor morphology (HP:0011063)1.72572702
67Septo-optic dysplasia (HP:0100842)1.71542986
68Widely spaced teeth (HP:0000687)1.71119931
69Poor coordination (HP:0002370)1.71065859
70Congenital primary aphakia (HP:0007707)1.70703753
71Shallow orbits (HP:0000586)1.70664496
72Hypoplastic iliac wings (HP:0002866)1.67612807
73Short hallux (HP:0010109)1.66668250
74Oligodactyly (hands) (HP:0001180)1.65705845
75Hypoplastic labia majora (HP:0000059)1.65420139
76Aplasia/Hypoplasia of the lens (HP:0008063)1.65124348
77Aplasia/Hypoplasia of the tibia (HP:0005772)1.64585705
78Hypothermia (HP:0002045)1.63895410
79Neoplasm of the heart (HP:0100544)1.63741948
80Hypoplastic nipples (HP:0002557)1.63167055
81Bony spicule pigmentary retinopathy (HP:0007737)1.62830648
82Anophthalmia (HP:0000528)1.61922905
83Neoplasm of the oral cavity (HP:0100649)1.61738798
84Bronchomalacia (HP:0002780)1.61296955
85Absent speech (HP:0001344)1.60303675
86Intestinal atresia (HP:0011100)1.57783219
87Aplasia/Hypoplasia of the hallux (HP:0008362)1.56899614
88Abnormal hair whorl (HP:0010721)1.56778683
89Duplicated collecting system (HP:0000081)1.56611646
90Bilateral microphthalmos (HP:0007633)1.56278586
91Nephrogenic diabetes insipidus (HP:0009806)1.56209252
92Tubulointerstitial abnormality (HP:0001969)1.56207304
93Congenital hepatic fibrosis (HP:0002612)1.55546103
942-3 toe syndactyly (HP:0004691)1.55138325
95Abnormality of the labia majora (HP:0012881)1.52191973
96Potter facies (HP:0002009)1.51671419
97Facial shape deformation (HP:0011334)1.51671419
98Cupped ear (HP:0000378)1.51574436
99Tubulointerstitial fibrosis (HP:0005576)1.51397021
100Highly arched eyebrow (HP:0002553)1.51102568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.55649318
2TIE13.57403982
3BMPR1B3.15892877
4CASK2.77829533
5PNCK2.40730936
6LATS12.30845556
7FGFR22.20192821
8MARK12.02624612
9WNK31.88769673
10CAMK1G1.88668443
11MAP3K41.77241571
12TNIK1.75608762
13STK38L1.73303290
14MAPK131.64421144
15INSRR1.61229303
16CAMK1D1.60285644
17NLK1.54770244
18TGFBR11.49186787
19TAOK31.48219428
20EPHB21.44333244
21MAPK151.43388906
22NTRK21.41074644
23OBSCN1.40946770
24PINK11.40276943
25SGK21.28878658
26AKT31.24932824
27NTRK31.24204122
28MAP4K21.23201267
29STK391.20629490
30GRK11.19682821
31MAP3K71.19312722
32PTK2B1.13001722
33SGK2231.09030683
34SGK4941.09030683
35FER1.08562576
36PAK31.06909753
37WNK41.03951948
38TYRO31.02222304
39NUAK11.00523450
40WNK11.00522444
41TRPM70.98124644
42PRKAA20.94544142
43ACVR1B0.92954870
44STK30.92870753
45PHKG10.91491064
46PHKG20.91491064
47EPHA30.90843324
48PRKAA10.88972040
49STK110.87668192
50ADRBK20.84053246
51PKN10.83882080
52OXSR10.83612188
53PRKCE0.82240929
54MAP3K90.79136297
55CAMK10.78951016
56ADRBK10.78487186
57EPHA40.73660798
58PASK0.73246804
59MARK20.72481512
60MYLK0.72434544
61PDGFRB0.69421045
62DYRK20.67478442
63PIK3CA0.67297011
64STK380.65947621
65MAPK70.65925597
66PRKCH0.64496792
67SGK30.62844087
68MAP2K40.59735837
69DAPK20.59517404
70CAMK40.59499914
71IRAK10.58622010
72PRKG10.57969261
73CDK30.57797086
74TGFBR20.56954652
75PRKCG0.56335332
76BRD40.55647167
77DYRK1A0.54011534
78TEC0.52627722
79PIK3CG0.52485732
80SIK20.52228047
81MELK0.50107356
82EEF2K0.49979237
83FGFR10.49559066
84MKNK20.48504989
85ZAK0.48379337
86FGFR30.47785471
87HIPK20.47399570
88ERBB30.47252662
89TNK20.47156058
90ROCK10.44520633
91MTOR0.43879219
92MAPK120.43142123
93ERBB20.42580814
94CAMK2A0.42066301
95DYRK1B0.41360481
96DYRK30.40813857
97CDK120.40640577
98MUSK0.40284090
99SGK10.38492085
100PRKD20.34676924

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047102.54412211
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.33779287
3Phototransduction_Homo sapiens_hsa047442.06408087
4Dorso-ventral axis formation_Homo sapiens_hsa043201.95720683
5Nicotine addiction_Homo sapiens_hsa050331.87386950
6Hedgehog signaling pathway_Homo sapiens_hsa043401.85903957
7Basal cell carcinoma_Homo sapiens_hsa052171.84326505
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80241972
9Nitrogen metabolism_Homo sapiens_hsa009101.77658982
10Insulin secretion_Homo sapiens_hsa049111.72914736
11Lysine degradation_Homo sapiens_hsa003101.70482140
12Taste transduction_Homo sapiens_hsa047421.69212103
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68515051
14Morphine addiction_Homo sapiens_hsa050321.61847607
15Glutamatergic synapse_Homo sapiens_hsa047241.59633686
16Linoleic acid metabolism_Homo sapiens_hsa005911.56418202
17Vascular smooth muscle contraction_Homo sapiens_hsa042701.54264538
18ECM-receptor interaction_Homo sapiens_hsa045121.52298203
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51801833
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51705948
21Circadian entrainment_Homo sapiens_hsa047131.51147391
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50732613
23TGF-beta signaling pathway_Homo sapiens_hsa043501.47290006
24Axon guidance_Homo sapiens_hsa043601.42325156
25Ovarian steroidogenesis_Homo sapiens_hsa049131.41031030
26Butanoate metabolism_Homo sapiens_hsa006501.40206536
27GABAergic synapse_Homo sapiens_hsa047271.37942190
28ABC transporters_Homo sapiens_hsa020101.34689381
29Serotonergic synapse_Homo sapiens_hsa047261.34207656
30Dilated cardiomyopathy_Homo sapiens_hsa054141.32189634
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.29589626
32Hippo signaling pathway_Homo sapiens_hsa043901.28850474
33Cardiac muscle contraction_Homo sapiens_hsa042601.28776361
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25886903
35Regulation of autophagy_Homo sapiens_hsa041401.14796710
36Adherens junction_Homo sapiens_hsa045201.10325188
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10313751
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08063069
39Ras signaling pathway_Homo sapiens_hsa040141.06863198
40Cholinergic synapse_Homo sapiens_hsa047251.05602235
41Protein digestion and absorption_Homo sapiens_hsa049741.04300519
42Dopaminergic synapse_Homo sapiens_hsa047281.04097199
43cAMP signaling pathway_Homo sapiens_hsa040241.03533809
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01084306
45Focal adhesion_Homo sapiens_hsa045101.01046885
46Calcium signaling pathway_Homo sapiens_hsa040201.01034284
47Wnt signaling pathway_Homo sapiens_hsa043101.00384434
48Notch signaling pathway_Homo sapiens_hsa043300.99459089
49Basal transcription factors_Homo sapiens_hsa030220.98797780
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97294841
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97011882
52Oxytocin signaling pathway_Homo sapiens_hsa049210.96745475
53Tight junction_Homo sapiens_hsa045300.96000804
54Ether lipid metabolism_Homo sapiens_hsa005650.95981034
55Long-term depression_Homo sapiens_hsa047300.95288456
56FoxO signaling pathway_Homo sapiens_hsa040680.94932990
57Olfactory transduction_Homo sapiens_hsa047400.94359997
58Cocaine addiction_Homo sapiens_hsa050300.93493678
59Melanogenesis_Homo sapiens_hsa049160.88579164
60MAPK signaling pathway_Homo sapiens_hsa040100.87557974
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86400866
62Tryptophan metabolism_Homo sapiens_hsa003800.82334966
63PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82236550
64Salivary secretion_Homo sapiens_hsa049700.78674571
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76695496
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76492761
67Rap1 signaling pathway_Homo sapiens_hsa040150.75960166
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75783364
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75241308
70Renin secretion_Homo sapiens_hsa049240.74685526
71Type II diabetes mellitus_Homo sapiens_hsa049300.73763463
72Choline metabolism in cancer_Homo sapiens_hsa052310.73378186
73Pathways in cancer_Homo sapiens_hsa052000.72726672
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70611379
75Renal cell carcinoma_Homo sapiens_hsa052110.70533571
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70161378
77Selenocompound metabolism_Homo sapiens_hsa004500.69650015
78Glycerolipid metabolism_Homo sapiens_hsa005610.69415286
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.68118019
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66444649
81Gastric acid secretion_Homo sapiens_hsa049710.65679604
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62969115
83Glucagon signaling pathway_Homo sapiens_hsa049220.61721525
84AMPK signaling pathway_Homo sapiens_hsa041520.61511749
85Propanoate metabolism_Homo sapiens_hsa006400.61424418
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61298096
87MicroRNAs in cancer_Homo sapiens_hsa052060.59961909
88Amphetamine addiction_Homo sapiens_hsa050310.58856466
89Bile secretion_Homo sapiens_hsa049760.58147468
90GnRH signaling pathway_Homo sapiens_hsa049120.56859789
91Thyroid hormone synthesis_Homo sapiens_hsa049180.55401688
92Melanoma_Homo sapiens_hsa052180.54012387
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53408028
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53319788
95Pancreatic secretion_Homo sapiens_hsa049720.52499338
96Prostate cancer_Homo sapiens_hsa052150.52125966
97Inositol phosphate metabolism_Homo sapiens_hsa005620.52095243
98Estrogen signaling pathway_Homo sapiens_hsa049150.50887292
99RNA degradation_Homo sapiens_hsa030180.50668796
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50563392

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