ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.18607970
2	nuclear pore complex assembly (GO:0051292)	3.89230383
3	nuclear pore organization (GO:0006999)	3.88359681
4	regulation of centriole replication (GO:0046599)	3.86946374
5	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.70330800
6	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.70330800
7	replication fork processing (GO:0031297)	3.64669578
8	ribosome assembly (GO:0042255)	3.61401862
9	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.59950993
10	maturation of 5.8S rRNA (GO:0000460)	3.53688643
11	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.44663569
12	nucleobase biosynthetic process (GO:0046112)	3.41359494
13	tRNA aminoacylation (GO:0043039)	3.28717511
14	amino acid activation (GO:0043038)	3.28717511
15	tRNA aminoacylation for protein translation (GO:0006418)	3.27209318
16	establishment of integrated proviral latency (GO:0075713)	3.27207707
17	proteasome assembly (GO:0043248)	3.23783543
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.20831678
19	regulation of centrosome duplication (GO:0010824)	3.18866795
20	regulation of helicase activity (GO:0051095)	3.13975706
21	non-recombinational repair (GO:0000726)	3.10707823
22	double-strand break repair via nonhomologous end joining (GO:0006303)	3.10707823
23	regulation of centrosome cycle (GO:0046605)	3.08236182
24	respiratory chain complex IV assembly (GO:0008535)	3.05351984
25	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.04141525
26	mitotic sister chromatid cohesion (GO:0007064)	3.03459819
27	purine nucleobase biosynthetic process (GO:0009113)	3.02147838
28	pseudouridine synthesis (GO:0001522)	2.99470038
29	chromatin remodeling at centromere (GO:0031055)	2.99404353
30	mitochondrial RNA metabolic process (GO:0000959)	2.98750308
31	DNA strand renaturation (GO:0000733)	2.96751885
32	recombinational repair (GO:0000725)	2.95966711
33	L-serine metabolic process (GO:0006563)	2.94461434
34	double-strand break repair via homologous recombination (GO:0000724)	2.94277910
35	DNA replication-dependent nucleosome assembly (GO:0006335)	2.93476433
36	DNA replication-dependent nucleosome organization (GO:0034723)	2.93476433
37	postreplication repair (GO:0006301)	2.92930142
38	pore complex assembly (GO:0046931)	2.92669147
39	response to X-ray (GO:0010165)	2.89242860
40	* tRNA metabolic process (GO:0006399)	2.88990700
41	biotin metabolic process (GO:0006768)	2.86948832
42	protein K6-linked ubiquitination (GO:0085020)	2.84367952
43	branched-chain amino acid catabolic process (GO:0009083)	2.82994491
44	telomere maintenance via telomerase (GO:0007004)	2.80518677
45	DNA strand elongation involved in DNA replication (GO:0006271)	2.80386897
46	somatic diversification of immunoglobulins (GO:0016445)	2.78626203
47	DNA catabolic process, exonucleolytic (GO:0000738)	2.77736322
48	aspartate family amino acid catabolic process (GO:0009068)	2.77630768
49	CENP-A containing nucleosome assembly (GO:0034080)	2.77301427
50	negative regulation of DNA recombination (GO:0045910)	2.75968504
51	DNA replication initiation (GO:0006270)	2.75405390
52	intra-S DNA damage checkpoint (GO:0031573)	2.74151592
53	DNA replication checkpoint (GO:0000076)	2.71938115
54	lysine catabolic process (GO:0006554)	2.71630525
55	lysine metabolic process (GO:0006553)	2.71630525
56	DNA strand elongation (GO:0022616)	2.70774538
57	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70044589
58	telomere maintenance via semi-conservative replication (GO:0032201)	2.68644814
59	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.68206230
60	regulation of mitotic spindle checkpoint (GO:1903504)	2.68206230
61	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.67152499
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.66835625
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.66835625
64	indolalkylamine metabolic process (GO:0006586)	2.66038101
65	* tRNA processing (GO:0008033)	2.65814966
66	DNA geometric change (GO:0032392)	2.65589702
67	viral mRNA export from host cell nucleus (GO:0046784)	2.64651214
68	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.64602216
69	isotype switching (GO:0045190)	2.64602216
70	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.64602216
71	RNA-dependent DNA replication (GO:0006278)	2.64569378
72	positive regulation of histone H3-K4 methylation (GO:0051571)	2.64179028
73	mitotic nuclear envelope disassembly (GO:0007077)	2.63899935
74	meiotic chromosome segregation (GO:0045132)	2.63736708
75	histone mRNA metabolic process (GO:0008334)	2.63614373
76	peptidyl-histidine modification (GO:0018202)	2.61982895
77	metaphase plate congression (GO:0051310)	2.59872584
78	attachment of spindle microtubules to kinetochore (GO:0008608)	2.59305698
79	mitotic recombination (GO:0006312)	2.58900030
80	telomere maintenance (GO:0000723)	2.58838170
81	somatic diversification of immune receptors (GO:0002200)	2.57854475
82	methionine biosynthetic process (GO:0009086)	2.57643441
83	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.57442435
84	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.57050852
85	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.56561213
86	ubiquinone metabolic process (GO:0006743)	2.56517825
87	histone exchange (GO:0043486)	2.56325826
88	telomere organization (GO:0032200)	2.56052629
89	sulfur amino acid biosynthetic process (GO:0000097)	2.55232904
90	reciprocal meiotic recombination (GO:0007131)	2.54946534
91	reciprocal DNA recombination (GO:0035825)	2.54946534
92	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.54786496
93	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.54183859
94	termination of RNA polymerase I transcription (GO:0006363)	2.54181252
95	ubiquinone biosynthetic process (GO:0006744)	2.53611997
96	protein-cofactor linkage (GO:0018065)	2.53493727
97	telomere maintenance via recombination (GO:0000722)	2.53385847
98	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.53151436
99	cytochrome complex assembly (GO:0017004)	2.53039045
100	mRNA cleavage (GO:0006379)	2.52887991

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.18774053
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52179928
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.22553082
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.22406813
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.15489137
6	* EST1_17652178_ChIP-ChIP_JURKAT_Human	2.92330079
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.81913576
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73846999
9	* ELK1_19687146_ChIP-ChIP_HELA_Human	2.67952046
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45296949
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40913523
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39561408
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.29906960
14	VDR_22108803_ChIP-Seq_LS180_Human	2.19208094
15	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.18720671
16	* VDR_23849224_ChIP-Seq_CD4+_Human	2.18262789
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.17492502
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13364974
19	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.10684624
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09626534
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08999878
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03418601
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.02582464
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01045160
25	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.98637662
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96353706
27	* ETS1_20019798_ChIP-Seq_JURKAT_Human	1.93922977
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.93478580
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.89110976
30	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81828576
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.76224332
32	FUS_26573619_Chip-Seq_HEK293_Human	1.73704696
33	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.71199584
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.68382523
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67493358
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66061138
37	EWS_26573619_Chip-Seq_HEK293_Human	1.66027494
38	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.64000173
39	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.62696416
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59466108
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.55231401
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.53600733
43	DCP1A_22483619_ChIP-Seq_HELA_Human	1.51699930
44	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.51626732
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.50084300
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.45101181
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.43993955
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40706852
49	AR_21909140_ChIP-Seq_LNCAP_Human	1.39519374
50	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.35255728
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.30307956
52	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.29545018
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.29014143
54	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.28341801
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26585007
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23277868
57	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.19099184
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.19058379
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18943997
60	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.17671861
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.14881878
62	P300_19829295_ChIP-Seq_ESCs_Human	1.13830324
63	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13607539
64	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.12303536
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.12217117
66	GBX2_23144817_ChIP-Seq_PC3_Human	1.09359259
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.09053062
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04690637
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02736427
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.02667256
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00779705
72	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.00676605
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00491635
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.98985668
75	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96659590
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96304486
77	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.95461927
78	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.93841007
79	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.91872866
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91748858
81	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.90726315
82	STAT3_23295773_ChIP-Seq_U87_Human	0.88999499
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88852741
84	CBP_20019798_ChIP-Seq_JUKART_Human	0.88852741
85	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.87668035
86	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.87070747
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.86046473
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.83700695
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83592444
90	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.83113699
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83068858
92	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82522721
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.82170558
94	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.82073344
95	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.81457701
96	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.81164630
97	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.80821561
98	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.80699903
99	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.80593888
100	TP53_22573176_ChIP-Seq_HFKS_Human	0.80574743

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.14448970
2	MP0010094_abnormal_chromosome_stability	4.00477685
3	MP0008058_abnormal_DNA_repair	3.51174023
4	MP0003693_abnormal_embryo_hatching	3.35606938
5	MP0008877_abnormal_DNA_methylation	3.11156149
6	MP0000569_abnormal_digit_pigmentation	2.83373672
7	MP0004957_abnormal_blastocyst_morpholog	2.76428083
8	MP0003111_abnormal_nucleus_morphology	2.74974407
9	MP0009697_abnormal_copulation	2.72609127
10	MP0003195_calcinosis	2.33869885
11	MP0003077_abnormal_cell_cycle	2.16641682
12	MP0003718_maternal_effect	2.14546452
13	MP0003806_abnormal_nucleotide_metabolis	2.12111801
14	MP0008007_abnormal_cellular_replicative	2.01483300
15	MP0003786_premature_aging	1.99080236
16	MP0008875_abnormal_xenobiotic_pharmacok	1.93548435
17	MP0006035_abnormal_mitochondrial_morpho	1.87063033
18	MP0003567_abnormal_fetal_cardiomyocyte	1.74350132
19	MP0003890_abnormal_embryonic-extraembry	1.73510317
20	MP0008932_abnormal_embryonic_tissue	1.70906662
21	MP0005084_abnormal_gallbladder_morpholo	1.66590853
22	MP0003941_abnormal_skin_development	1.66540113
23	MP0000427_abnormal_hair_cycle	1.63112562
24	MP0000358_abnormal_cell_content/	1.52563802
25	MP0005075_abnormal_melanosome_morpholog	1.50640129
26	MP0003646_muscle_fatigue	1.46151132
27	MP0003136_yellow_coat_color	1.45579200
28	MP0005365_abnormal_bile_salt	1.44137903
29	MP0001764_abnormal_homeostasis	1.42252497
30	MP0006072_abnormal_retinal_apoptosis	1.41036121
31	MP0002396_abnormal_hematopoietic_system	1.40887921
32	MP0000647_abnormal_sebaceous_gland	1.35871849
33	MP0003937_abnormal_limbs/digits/tail_de	1.34421037
34	MP0003943_abnormal_hepatobiliary_system	1.34230890
35	MP0003950_abnormal_plasma_membrane	1.33854606
36	MP0002160_abnormal_reproductive_system	1.29011371
37	MP0005551_abnormal_eye_electrophysiolog	1.27943655
38	MP0005408_hypopigmentation	1.27390858
39	MP0000372_irregular_coat_pigmentation	1.27155122
40	MP0010307_abnormal_tumor_latency	1.24851000
41	MP0001293_anophthalmia	1.24516925
42	MP0001730_embryonic_growth_arrest	1.24280212
43	MP0005389_reproductive_system_phenotype	1.22563879
44	MP0000383_abnormal_hair_follicle	1.21157887
45	MP0002254_reproductive_system_inflammat	1.20470963
46	MP0001672_abnormal_embryogenesis/_devel	1.16113806
47	MP0005380_embryogenesis_phenotype	1.16113806
48	MP0005395_other_phenotype	1.14096590
49	MP0002938_white_spotting	1.13307517
50	MP0001666_abnormal_nutrient_absorption	1.11701738
51	MP0002090_abnormal_vision	1.11122222
52	MP0001697_abnormal_embryo_size	1.09537351
53	MP0005253_abnormal_eye_physiology	1.08578764
54	MP0002088_abnormal_embryonic_growth/wei	1.07576906
55	MP0001661_extended_life_span	1.05188465
56	MP0003121_genomic_imprinting	1.05044477
57	MP0003984_embryonic_growth_retardation	1.04643329
58	MP0002084_abnormal_developmental_patter	1.03172032
59	MP0001929_abnormal_gametogenesis	1.02565904
60	MP0003787_abnormal_imprinting	1.02448515
61	MP0005379_endocrine/exocrine_gland_phen	1.00884972
62	MP0001286_abnormal_eye_development	1.00730968
63	MP0006292_abnormal_olfactory_placode	0.96984528
64	MP0003186_abnormal_redox_activity	0.95242360
65	MP0009703_decreased_birth_body	0.93626307
66	MP0001324_abnormal_eye_pigmentation	0.93586680
67	MP0001919_abnormal_reproductive_system	0.91791269
68	MP0002210_abnormal_sex_determination	0.90966593
69	MP0005085_abnormal_gallbladder_physiolo	0.90838838
70	MP0001145_abnormal_male_reproductive	0.90669067
71	MP0002736_abnormal_nociception_after	0.90194061
72	MP0008872_abnormal_physiological_respon	0.89398813
73	MP0003252_abnormal_bile_duct	0.88923757
74	MP0004197_abnormal_fetal_growth/weight/	0.88567884
75	MP0001119_abnormal_female_reproductive	0.88500171
76	MP0010678_abnormal_skin_adnexa	0.88428946
77	MP0010329_abnormal_lipoprotein_level	0.87616403
78	MP0000653_abnormal_sex_gland	0.87071691
79	MP0000350_abnormal_cell_proliferation	0.86822269
80	MP0004043_abnormal_pH_regulation	0.85449596
81	MP0002019_abnormal_tumor_incidence	0.85145564
82	MP0004381_abnormal_hair_follicle	0.84990084
83	MP0002080_prenatal_lethality	0.82957587
84	MP0005645_abnormal_hypothalamus_physiol	0.82901731
85	MP0002095_abnormal_skin_pigmentation	0.82370472
86	MP0005332_abnormal_amino_acid	0.81725818
87	MP0001529_abnormal_vocalization	0.81659088
88	MP0004133_heterotaxia	0.81511369
89	MP0001984_abnormal_olfaction	0.81265180
90	MP0003698_abnormal_male_reproductive	0.79318820
91	MP0002102_abnormal_ear_morphology	0.79183634
92	MP0005174_abnormal_tail_pigmentation	0.76747101
93	MP0002085_abnormal_embryonic_tissue	0.73569119
94	MP0002751_abnormal_autonomic_nervous	0.73141076
95	MP0005646_abnormal_pituitary_gland	0.73081749
96	MP0009672_abnormal_birth_weight	0.73022331
97	MP0002086_abnormal_extraembryonic_tissu	0.70940092
98	MP0006054_spinal_hemorrhage	0.70209314
99	MP0000313_abnormal_cell_death	0.69609594
100	MP0000015_abnormal_ear_pigmentation	0.68953655

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	3.39553384
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.17052917
3	Meckel diverticulum (HP:0002245)	3.09097652
4	Hyperglycinemia (HP:0002154)	3.08522425
5	Renal cortical cysts (HP:0000803)	3.07760965
6	Abnormality of chromosome stability (HP:0003220)	3.07273992
7	Abnormality of the ileum (HP:0001549)	3.05352150
8	Pancreatic cysts (HP:0001737)	2.85021071
9	Medial flaring of the eyebrow (HP:0010747)	2.83492495
10	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.82325308
11	Pancreatic fibrosis (HP:0100732)	2.78924755
12	Abnormality of methionine metabolism (HP:0010901)	2.71414783
13	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.71220714
14	Abnormal protein N-linked glycosylation (HP:0012347)	2.71220714
15	Abnormal protein glycosylation (HP:0012346)	2.71220714
16	Abnormal glycosylation (HP:0012345)	2.71220714
17	Abnormality of the preputium (HP:0100587)	2.66644359
18	Colon cancer (HP:0003003)	2.64511430
19	Hyperglycinuria (HP:0003108)	2.63388696
20	Nephroblastoma (Wilms tumor) (HP:0002667)	2.62574279
21	Hypothermia (HP:0002045)	2.55212140
22	Type I transferrin isoform profile (HP:0003642)	2.54898127
23	Abnormality of the renal cortex (HP:0011035)	2.52874895
24	Pancreatic islet-cell hyperplasia (HP:0004510)	2.51836610
25	Embryonal renal neoplasm (HP:0011794)	2.47698952
26	Bile duct proliferation (HP:0001408)	2.47238975
27	Abnormal biliary tract physiology (HP:0012439)	2.47238975
28	Abnormality of serine family amino acid metabolism (HP:0010894)	2.44993654
29	Abnormality of glycine metabolism (HP:0010895)	2.44993654
30	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.40335252
31	Ependymoma (HP:0002888)	2.39943346
32	Abnormality of serum amino acid levels (HP:0003112)	2.39332899
33	Sloping forehead (HP:0000340)	2.32992068
34	Lipid accumulation in hepatocytes (HP:0006561)	2.32336993
35	True hermaphroditism (HP:0010459)	2.31777237
36	Limb hypertonia (HP:0002509)	2.25868462
37	Microvesicular hepatic steatosis (HP:0001414)	2.24533811
38	Glioma (HP:0009733)	2.23724465
39	Reduced antithrombin III activity (HP:0001976)	2.23618884
40	Birth length less than 3rd percentile (HP:0003561)	2.20152194
41	Increased serum pyruvate (HP:0003542)	2.19873691
42	Congenital primary aphakia (HP:0007707)	2.19504658
43	Hepatic necrosis (HP:0002605)	2.18632924
44	Acute encephalopathy (HP:0006846)	2.17582297
45	Poikiloderma (HP:0001029)	2.16084934
46	Small intestinal stenosis (HP:0012848)	2.13580552
47	Duodenal stenosis (HP:0100867)	2.13580552
48	Volvulus (HP:0002580)	2.13316712
49	Hepatocellular necrosis (HP:0001404)	2.11940613
50	Increased hepatocellular lipid droplets (HP:0006565)	2.11869443
51	Bifid tongue (HP:0010297)	2.11797267
52	Increased serum lactate (HP:0002151)	2.11709764
53	Increased CSF lactate (HP:0002490)	2.10040858
54	Prolonged partial thromboplastin time (HP:0003645)	2.08350646
55	Methylmalonic acidemia (HP:0002912)	2.08234657
56	Molar tooth sign on MRI (HP:0002419)	2.08065372
57	Abnormality of midbrain morphology (HP:0002418)	2.08065372
58	Astrocytoma (HP:0009592)	2.04802941
59	Abnormality of the astrocytes (HP:0100707)	2.04802941
60	Nephrogenic diabetes insipidus (HP:0009806)	2.02850924
61	Gait imbalance (HP:0002141)	1.99509297
62	Genital tract atresia (HP:0001827)	1.95499418
63	Abnormal lung lobation (HP:0002101)	1.95487749
64	Hypoglycemic coma (HP:0001325)	1.93850488
65	Abnormality of glycolysis (HP:0004366)	1.93559409
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.93140818
67	Abnormality of alanine metabolism (HP:0010916)	1.93140818
68	Hyperalaninemia (HP:0003348)	1.93140818
69	Clubbing of toes (HP:0100760)	1.92439040
70	Progressive inability to walk (HP:0002505)	1.90876121
71	Abnormality of the labia minora (HP:0012880)	1.90276232
72	Hypobetalipoproteinemia (HP:0003563)	1.89948105
73	Abnormality of DNA repair (HP:0003254)	1.88360617
74	Vaginal atresia (HP:0000148)	1.86603029
75	Acute necrotizing encephalopathy (HP:0006965)	1.86212150
76	Brittle hair (HP:0002299)	1.86057282
77	Abnormality of the duodenum (HP:0002246)	1.85827574
78	Abolished electroretinogram (ERG) (HP:0000550)	1.84939186
79	Lissencephaly (HP:0001339)	1.83802381
80	Myelodysplasia (HP:0002863)	1.83611833
81	Breast carcinoma (HP:0003002)	1.82920240
82	Poor coordination (HP:0002370)	1.81193648
83	Hyperammonemia (HP:0001987)	1.80834812
84	Rhabdomyosarcoma (HP:0002859)	1.80350310
85	Mitochondrial inheritance (HP:0001427)	1.74286785
86	Lethargy (HP:0001254)	1.73546737
87	Ketosis (HP:0001946)	1.71622781
88	Neoplasm of the adrenal gland (HP:0100631)	1.70291504
89	Cerebral edema (HP:0002181)	1.70076847
90	Central scotoma (HP:0000603)	1.69843162
91	Lactic acidosis (HP:0003128)	1.69322510
92	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.68318682
93	Biliary tract neoplasm (HP:0100574)	1.67277607
94	CNS demyelination (HP:0007305)	1.67253855
95	Hyperventilation (HP:0002883)	1.66332487
96	Dandy-Walker malformation (HP:0001305)	1.65171148
97	Neoplasm of the colon (HP:0100273)	1.64719083
98	Chronic hepatic failure (HP:0100626)	1.64638384
99	Abnormality of the carotid arteries (HP:0005344)	1.64089069
100	Astigmatism (HP:0000483)	1.63627798

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.12029997
2	ZAK	3.10073706
3	EIF2AK1	2.94516605
4	PBK	2.84110803
5	EIF2AK3	2.83803834
6	SRPK1	2.83257359
7	TSSK6	2.74721994
8	BUB1	2.74563538
9	BRSK2	2.74390049
10	MAP4K2	2.59725448
11	NUAK1	2.48392901
12	CDC7	2.27744290
13	VRK2	2.14150626
14	MST4	2.02968118
15	TTK	1.95688064
16	PLK3	1.95357870
17	BMPR1B	1.93568038
18	TAF1	1.91837066
19	VRK1	1.90077431
20	NEK1	1.87139195
21	ACVR1B	1.79002246
22	MKNK2	1.75621899
23	WNK3	1.70582873
24	WEE1	1.58091241
25	MKNK1	1.58028382
26	INSRR	1.51932363
27	TRIM28	1.51715899
28	PLK4	1.49871550
29	SCYL2	1.43453103
30	BRD4	1.35948994
31	STK39	1.35795849
32	MAP3K12	1.31504277
33	ATR	1.27358738
34	TXK	1.26554186
35	BCR	1.23941543
36	FLT3	1.22440973
37	PLK1	1.16209701
38	CHEK2	1.11779886
39	NME1	1.11319976
40	BCKDK	1.10763579
41	EIF2AK2	1.08617709
42	PINK1	1.00353162
43	TEC	0.98356659
44	OXSR1	0.91827922
45	TGFBR1	0.91093318
46	ATM	0.88859752
47	ADRBK2	0.88741457
48	BRSK1	0.87883603
49	GRK1	0.82510030
50	ERBB3	0.81952759
51	LATS1	0.81924979
52	STK16	0.80538925
53	RPS6KB2	0.79896379
54	WNK4	0.79367654
55	MAPKAPK5	0.77792194
56	CSNK1G1	0.77696619
57	TLK1	0.77177395
58	STK38L	0.75256116
59	ERBB4	0.73784718
60	PLK2	0.72177521
61	AURKB	0.68620082
62	NEK2	0.67829676
63	PIK3CA	0.67413414
64	RPS6KA4	0.65137421
65	PASK	0.64733969
66	ITK	0.63980015
67	FGFR3	0.63974452
68	CHEK1	0.63161845
69	IRAK1	0.62445020
70	MAPKAPK3	0.57138657
71	STK3	0.56739051
72	TRPM7	0.56390310
73	FGFR1	0.55128479
74	CSNK1A1L	0.54241119
75	CLK1	0.53977306
76	FER	0.51547632
77	CSNK1G3	0.49921423
78	NLK	0.48728266
79	MELK	0.48349261
80	CDK7	0.47137391
81	RPS6KA5	0.45630670
82	MAP3K4	0.45102126
83	PNCK	0.44063679
84	CSNK2A1	0.43162707
85	PRKCE	0.42656288
86	CSNK2A2	0.42513999
87	CSNK1G2	0.40621768
88	CDK1	0.39807788
89	IGF1R	0.39335668
90	RPS6KB1	0.37857475
91	CSNK1A1	0.35234382
92	CDK12	0.33017919
93	CDK6	0.32810954
94	CSNK1E	0.31573960
95	CSNK1D	0.30303209
96	CCNB1	0.30170540
97	TAOK3	0.29828090
98	MAP2K7	0.28248171
99	STK10	0.27620075
100	PKN2	0.26539338

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.48543310
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.90540788
3	Proteasome_Homo sapiens_hsa03050	2.86828082
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.84527841
5	Propanoate metabolism_Homo sapiens_hsa00640	2.69016881
6	Homologous recombination_Homo sapiens_hsa03440	2.61286260
7	One carbon pool by folate_Homo sapiens_hsa00670	2.53135319
8	DNA replication_Homo sapiens_hsa03030	2.52619060
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.43783209
10	Mismatch repair_Homo sapiens_hsa03430	2.41728099
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38277175
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.22532071
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13777220
14	Steroid biosynthesis_Homo sapiens_hsa00100	2.10208657
15	Protein export_Homo sapiens_hsa03060	2.04173820
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02046547
17	RNA polymerase_Homo sapiens_hsa03020	1.95584946
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.94751528
19	RNA transport_Homo sapiens_hsa03013	1.94044896
20	Basal transcription factors_Homo sapiens_hsa03022	1.90889858
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.82980102
22	RNA degradation_Homo sapiens_hsa03018	1.81326436
23	Base excision repair_Homo sapiens_hsa03410	1.74536603
24	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.67311974
25	Spliceosome_Homo sapiens_hsa03040	1.67076842
26	Butanoate metabolism_Homo sapiens_hsa00650	1.65385111
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.63796241
28	Fatty acid elongation_Homo sapiens_hsa00062	1.62386456
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.58816539
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58795100
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.53293252
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.41011088
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.40572911
34	Peroxisome_Homo sapiens_hsa04146	1.36196120
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35719982
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.28778903
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.27030904
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.24957740
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.24223206
40	Cell cycle_Homo sapiens_hsa04110	1.22173867
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20830641
42	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.18384648
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.11494081
44	Fatty acid degradation_Homo sapiens_hsa00071	1.05436810
45	Purine metabolism_Homo sapiens_hsa00230	1.01866859
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01780123
47	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.01414855
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.92485476
49	mRNA surveillance pathway_Homo sapiens_hsa03015	0.91421494
50	Lysine degradation_Homo sapiens_hsa00310	0.87977180
51	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.87027509
52	Caffeine metabolism_Homo sapiens_hsa00232	0.83448160
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.83062601
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79236613
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.78401691
56	p53 signaling pathway_Homo sapiens_hsa04115	0.73464669
57	Metabolic pathways_Homo sapiens_hsa01100	0.72745381
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70638837
59	Carbon metabolism_Homo sapiens_hsa01200	0.70521251
60	Histidine metabolism_Homo sapiens_hsa00340	0.70428589
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70108128
62	Oxidative phosphorylation_Homo sapiens_hsa00190	0.70016537
63	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69064319
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68654434
65	Phototransduction_Homo sapiens_hsa04744	0.67360118
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.65391811
67	Parkinsons disease_Homo sapiens_hsa05012	0.64548167
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61527807
69	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60547895
70	ABC transporters_Homo sapiens_hsa02010	0.59463420
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58359191
72	Retinol metabolism_Homo sapiens_hsa00830	0.56940214
73	Sulfur metabolism_Homo sapiens_hsa00920	0.56665386
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56532478
75	Glutathione metabolism_Homo sapiens_hsa00480	0.53849285
76	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51889219
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.51590354
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50687284
79	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50307802
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45843359
81	Complement and coagulation cascades_Homo sapiens_hsa04610	0.45730265
82	Ribosome_Homo sapiens_hsa03010	0.45031180
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44751333
84	Linoleic acid metabolism_Homo sapiens_hsa00591	0.44142596
85	Ether lipid metabolism_Homo sapiens_hsa00565	0.41226244
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.40913786
87	Huntingtons disease_Homo sapiens_hsa05016	0.39896970
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37060410
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35052954
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34637929
91	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33709752
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30957248
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.30127332
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26751080
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.23389835
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23189992
97	Oocyte meiosis_Homo sapiens_hsa04114	0.22775762
98	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.22253708
99	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.20568383
100	Alcoholism_Homo sapiens_hsa05034	0.20005218

KIAA0391

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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