KIAA0430

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.32562590
2negative regulation of cell killing (GO:0031342)5.24132794
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.24132794
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.61661692
5regulation of B cell receptor signaling pathway (GO:0050855)4.59339081
6regulation of gamma-delta T cell activation (GO:0046643)4.03199766
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00890748
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.00890748
9modulation by symbiont of host immune response (GO:0052553)4.00890748
10positive regulation by symbiont of host defense response (GO:0052509)4.00890748
11modulation by symbiont of host defense response (GO:0052031)4.00890748
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00890748
13regulation of gamma-delta T cell differentiation (GO:0045586)3.98204567
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.97728607
15antigen processing and presentation of endogenous antigen (GO:0019883)3.86200148
16detection of other organism (GO:0098543)3.70603903
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70222989
18macrophage activation involved in immune response (GO:0002281)3.69216182
19negative regulation of erythrocyte differentiation (GO:0045647)3.68828502
20B cell receptor signaling pathway (GO:0050853)3.65249714
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.64491235
22cellular extravasation (GO:0045123)3.62149756
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60784016
24negative thymic T cell selection (GO:0045060)3.57903385
25detection of molecule of bacterial origin (GO:0032490)3.56033381
26positive thymic T cell selection (GO:0045059)3.53708959
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.49112793
28negative T cell selection (GO:0043383)3.47947305
29response to interleukin-15 (GO:0070672)3.46051695
30positive T cell selection (GO:0043368)3.45915154
31detection of bacterium (GO:0016045)3.44245846
32histone H3-K36 demethylation (GO:0070544)3.38275898
33detection of external biotic stimulus (GO:0098581)3.36753921
34microglial cell activation (GO:0001774)3.28516271
35negative regulation of T cell mediated immunity (GO:0002710)3.21949743
36leukocyte aggregation (GO:0070486)3.14977287
37regulation of ARF protein signal transduction (GO:0032012)3.10446353
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08394946
39germinal center formation (GO:0002467)3.08244317
40T cell selection (GO:0045058)3.07667274
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05556659
42negative regulation of leukocyte mediated immunity (GO:0002704)3.05172714
43activated T cell proliferation (GO:0050798)3.03438693
44positive regulation of Rap GTPase activity (GO:0032854)3.02514615
45macrophage activation (GO:0042116)2.95365316
46thymic T cell selection (GO:0045061)2.93919736
47response to muramyl dipeptide (GO:0032495)2.91939812
48cellular response to interleukin-15 (GO:0071350)2.89530713
49positive regulation of granulocyte differentiation (GO:0030854)2.89061331
50neutrophil activation involved in immune response (GO:0002283)2.88919575
51response to host immune response (GO:0052572)2.88743096
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88743096
53detection of biotic stimulus (GO:0009595)2.86129980
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85990613
55response to host (GO:0075136)2.85903172
56response to host defenses (GO:0052200)2.85903172
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.85903172
58negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82219937
59negative regulation of T-helper cell differentiation (GO:0045623)2.82219937
60response to peptidoglycan (GO:0032494)2.81184298
61positive regulation of cellular amide metabolic process (GO:0034250)2.80471629
62neutrophil mediated immunity (GO:0002446)2.77766311
63regulation of interferon-beta biosynthetic process (GO:0045357)2.76017127
64regulation of B cell differentiation (GO:0045577)2.75778477
65regulation of beta-amyloid formation (GO:1902003)2.75042402
66negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.72544234
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71286977
68production of molecular mediator involved in inflammatory response (GO:0002532)2.70370393
69positive regulation of B cell differentiation (GO:0045579)2.69332751
70hypotonic response (GO:0006971)2.68800385
71regulation of T-helper 2 cell differentiation (GO:0045628)2.67773189
72negative regulation of interleukin-12 production (GO:0032695)2.64076826
73negative regulation of immunoglobulin mediated immune response (GO:0002890)2.61509454
74negative regulation of B cell mediated immunity (GO:0002713)2.61509454
75myeloid cell activation involved in immune response (GO:0002275)2.60405632
76regulation of Rap GTPase activity (GO:0032317)2.59950302
77myeloid leukocyte mediated immunity (GO:0002444)2.59802880
78regulation of amyloid precursor protein catabolic process (GO:1902991)2.57906418
79negative regulation of type 2 immune response (GO:0002829)2.55272158
80antigen processing and presentation via MHC class Ib (GO:0002475)2.54916520
81regulation of necroptotic process (GO:0060544)2.54621357
82histone H3-K9 demethylation (GO:0033169)2.50358820
83histone H3-K4 trimethylation (GO:0080182)2.50286182
84regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49281002
85negative regulation of adaptive immune response (GO:0002820)2.48835319
86regulation of leukocyte degranulation (GO:0043300)2.48639238
87regulation of mast cell degranulation (GO:0043304)2.47589564
88neutrophil activation (GO:0042119)2.47549168
89tolerance induction (GO:0002507)2.47223915
90regulation of tolerance induction (GO:0002643)2.45761397
91positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43047571
92negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40612387
93regulation of platelet aggregation (GO:0090330)2.39050562
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.38512986
95antigen receptor-mediated signaling pathway (GO:0050851)2.38196494
96positive regulation of receptor recycling (GO:0001921)2.35143993
97regulation of cellular amide metabolic process (GO:0034248)2.34078752
98regulation of regulated secretory pathway (GO:1903305)2.33958469
99cellular response to epinephrine stimulus (GO:0071872)2.33464937
100histone lysine demethylation (GO:0070076)2.33289789

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14627862
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86402530
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.58590098
4RUNX_20019798_ChIP-Seq_JUKART_Human2.81792499
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.66837579
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60824142
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58173270
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52317507
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.47796026
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.41047058
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40258705
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.26710202
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22491247
14SCL_19346495_ChIP-Seq_HPC-7_Human2.21927201
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19296532
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.11024569
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10114394
18SPI1_23127762_ChIP-Seq_K562_Human2.09286109
19TCF7_22412390_ChIP-Seq_EML_Mouse2.03076480
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.97627953
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.97071592
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.86571516
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83683146
24GATA1_22025678_ChIP-Seq_K562_Human1.81071462
25KDM2B_26808549_Chip-Seq_DND41_Human1.78713809
26VDR_24763502_ChIP-Seq_THP-1_Human1.77566367
27MYB_26560356_Chip-Seq_TH2_Human1.77164812
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76057581
29* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72926547
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71860055
31MYC_22102868_ChIP-Seq_BL_Human1.71524094
32MAF_26560356_Chip-Seq_TH1_Human1.69753893
33GATA1_19941827_ChIP-Seq_MEL_Mouse1.69142782
34VDR_24787735_ChIP-Seq_THP-1_Human1.69114494
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59922321
36GATA1_19941826_ChIP-Seq_K562_Human1.56046874
37MYB_26560356_Chip-Seq_TH1_Human1.52854853
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52747314
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.48653964
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48408879
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.48228950
42DROSHA_22980978_ChIP-Seq_HELA_Human1.47978396
43VDR_21846776_ChIP-Seq_THP-1_Human1.46531618
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44292287
45* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44006320
46UTX_26944678_Chip-Seq_JUKART_Human1.41637497
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40994752
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40770517
49GATA3_27048872_Chip-Seq_THYMUS_Human1.39435380
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.39309563
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31970595
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31534735
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29976318
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27641100
55SPI1_23547873_ChIP-Seq_NB4_Human1.26750496
56KDM2B_26808549_Chip-Seq_K562_Human1.26731959
57GATA2_19941826_ChIP-Seq_K562_Human1.26691442
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26625189
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23839914
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16680067
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15281083
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14415866
63PU_27001747_Chip-Seq_BMDM_Mouse1.13435355
64MAF_26560356_Chip-Seq_TH2_Human1.09160411
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08963927
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08055925
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04328218
68* FOXO3_23340844_ChIP-Seq_DLD1_Human1.04265957
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04044758
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02784456
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01630681
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01410217
73GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00715824
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00438735
75* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98072847
76* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97220532
77RARB_27405468_Chip-Seq_BRAIN_Mouse0.95793786
78ESR1_20079471_ChIP-ChIP_T-47D_Human0.92872240
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92780334
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92307429
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87576041
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86636194
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86038370
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85599558
85GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85446195
86TP53_16413492_ChIP-PET_HCT116_Human0.85120802
87ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84094876
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82922849
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.82782736
90AR_21572438_ChIP-Seq_LNCaP_Human0.81877310
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81711242
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80467203
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79863095
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.79857537
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79531518
96GATA3_26560356_Chip-Seq_TH2_Human0.76844082
97TBX20_22080862_ChIP-Seq_HEART_Mouse0.76415084
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.76415084
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75591388
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75122028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.73985616
2MP0003303_peritoneal_inflammation3.30541353
3MP0003436_decreased_susceptibility_to3.18790523
4MP0001835_abnormal_antigen_presentation2.96522495
5MP0000569_abnormal_digit_pigmentation2.81341881
6MP0008260_abnormal_autophagy2.81060209
7MP0003763_abnormal_thymus_physiology2.73301326
8MP0003300_gastrointestinal_ulcer2.68596091
9MP0003172_abnormal_lysosome_physiology2.63178965
10MP0001800_abnormal_humoral_immune2.48842074
11MP0002419_abnormal_innate_immunity2.24476186
12MP0000685_abnormal_immune_system2.19285074
13MP0005387_immune_system_phenotype2.14237274
14MP0001790_abnormal_immune_system2.14237274
15MP0005000_abnormal_immune_tolerance2.13667813
16MP0005025_abnormal_response_to2.09805748
17MP0003828_pulmonary_edema2.05693406
18MP0002723_abnormal_immune_serum2.01284223
19MP0002420_abnormal_adaptive_immunity2.00273540
20MP0003656_abnormal_erythrocyte_physiolo1.97649737
21MP0001819_abnormal_immune_cell1.96177618
22MP0004381_abnormal_hair_follicle1.95880962
23MP0003690_abnormal_glial_cell1.95133325
24MP0002396_abnormal_hematopoietic_system1.89294176
25MP0002452_abnormal_antigen_presenting1.88584393
26MP0005451_abnormal_body_composition1.84281881
27MP0003191_abnormal_cellular_cholesterol1.84119519
28MP0005464_abnormal_platelet_physiology1.79380093
29MP0002398_abnormal_bone_marrow1.77951843
30MP0005671_abnormal_response_to1.73910112
31MP0005409_darkened_coat_color1.73863566
32MP0002405_respiratory_system_inflammati1.73510587
33MP0003183_abnormal_peptide_metabolism1.70459068
34MP0003866_abnormal_defecation1.64507333
35MP0004883_abnormal_blood_vessel1.63847597
36MP0000716_abnormal_immune_system1.61407857
37MP0004130_abnormal_muscle_cell1.57632646
38MP0009785_altered_susceptibility_to1.55019650
39MP0002166_altered_tumor_susceptibility1.54948913
40MP0004947_skin_inflammation1.54283176
41MP0000703_abnormal_thymus_morphology1.51533992
42MP0001533_abnormal_skeleton_physiology1.48129222
43MP0001851_eye_inflammation1.46150223
44MP0003091_abnormal_cell_migration1.42844430
45MP0009278_abnormal_bone_marrow1.39847046
46MP0004859_abnormal_synaptic_plasticity1.38173594
47MP0002009_preneoplasia1.37826402
48MP0010155_abnormal_intestine_physiology1.37693638
49MP0003787_abnormal_imprinting1.37573195
50MP0003045_fibrosis1.37198956
51MP0002722_abnormal_immune_system1.35238743
52MP0000689_abnormal_spleen_morphology1.34145548
53MP0000465_gastrointestinal_hemorrhage1.33938497
54MP0005310_abnormal_salivary_gland1.27238102
55MP0003329_amyloid_beta_deposits1.27041610
56MP0004808_abnormal_hematopoietic_stem1.26252736
57MP0006082_CNS_inflammation1.24290260
58MP0004510_myositis1.21704330
59MP0002429_abnormal_blood_cell1.20331300
60MP0002998_abnormal_bone_remodeling1.16575820
61MP0000604_amyloidosis1.15807707
62MP0001545_abnormal_hematopoietic_system1.15611503
63MP0005397_hematopoietic_system_phenotyp1.15611503
64MP0000015_abnormal_ear_pigmentation1.14710053
65MP0001845_abnormal_inflammatory_respons1.14668491
66MP0005164_abnormal_response_to1.09226555
67MP0002148_abnormal_hypersensitivity_rea1.07365032
68MP0001958_emphysema1.06474458
69MP0002132_abnormal_respiratory_system1.06250180
70MP0004484_altered_response_of1.04551246
71MP0008569_lethality_at_weaning1.02388061
72MP0000920_abnormal_myelination0.99328197
73MP0000858_altered_metastatic_potential0.99034732
74MP0009333_abnormal_splenocyte_physiolog0.96852396
75MP0003075_altered_response_to0.95341807
76MP0005076_abnormal_cell_differentiation0.94105292
77MP0003221_abnormal_cardiomyocyte_apopto0.90127633
78MP0009115_abnormal_fat_cell0.88506266
79MP0008874_decreased_physiological_sensi0.88176399
80MP0002133_abnormal_respiratory_system0.88099873
81MP0005388_respiratory_system_phenotype0.88099873
82MP0005166_decreased_susceptibility_to0.86540250
83MP0005075_abnormal_melanosome_morpholog0.85732833
84MP0005058_abnormal_lysosome_morphology0.79807673
85MP0000249_abnormal_blood_vessel0.79627707
86MP0002006_tumorigenesis0.76835594
87MP0002971_abnormal_brown_adipose0.76009783
88MP0002332_abnormal_exercise_endurance0.75761997
89MP0008469_abnormal_protein_level0.75394703
90MP0008004_abnormal_stomach_pH0.73974257
91MP0005666_abnormal_adipose_tissue0.71173129
92MP0003635_abnormal_synaptic_transmissio0.70102660
93MP0002933_joint_inflammation0.69040471
94MP0003705_abnormal_hypodermis_morpholog0.67747762
95MP0003632_abnormal_nervous_system0.67577622
96MP0005423_abnormal_somatic_nervous0.67050311
97MP0005621_abnormal_cell_physiology0.65258021
98MP0005535_abnormal_body_temperature0.64092596
99MP0001501_abnormal_sleep_pattern0.63216586
100MP0004185_abnormal_adipocyte_glucose0.62902876

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.87057232
2Recurrent bacterial skin infections (HP:0005406)4.09256702
3Recurrent abscess formation (HP:0002722)3.79973133
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.67036651
5Myositis (HP:0100614)3.42976492
6Papilledema (HP:0001085)3.41435795
7Gastrointestinal infarctions (HP:0005244)3.38439329
8Spontaneous hematomas (HP:0007420)3.37162834
9Recurrent gram-negative bacterial infections (HP:0005420)3.22561461
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.21811653
11Orchitis (HP:0100796)3.20514868
12Recurrent fungal infections (HP:0002841)3.20132659
13Obstructive sleep apnea (HP:0002870)3.11042383
14Retrobulbar optic neuritis (HP:0100654)3.10327370
15Optic neuritis (HP:0100653)3.10327370
16T lymphocytopenia (HP:0005403)3.07488291
17Abnormality of the fingertips (HP:0001211)3.03885145
18Gingivitis (HP:0000230)2.91759055
19Abnormality of macrophages (HP:0004311)2.89647315
20Recurrent skin infections (HP:0001581)2.88622535
21Abnormality of T cell number (HP:0011839)2.85213245
22Prolonged bleeding time (HP:0003010)2.84606517
23Gingival bleeding (HP:0000225)2.83950623
24Meningitis (HP:0001287)2.81280851
25Slow saccadic eye movements (HP:0000514)2.80637907
26Recurrent cutaneous fungal infections (HP:0011370)2.77220827
27Chronic mucocutaneous candidiasis (HP:0002728)2.77220827
28Cellulitis (HP:0100658)2.73616510
29Chest pain (HP:0100749)2.65061052
30Mediastinal lymphadenopathy (HP:0100721)2.64418937
31Elevated erythrocyte sedimentation rate (HP:0003565)2.62633073
32Vasculitis (HP:0002633)2.61653284
33Hypochromic microcytic anemia (HP:0004840)2.50003220
34Stomatitis (HP:0010280)2.49972221
35Difficulty running (HP:0009046)2.48757262
36Increased IgE level (HP:0003212)2.48597914
37Keratoconjunctivitis sicca (HP:0001097)2.48361648
38Subacute progressive viral hepatitis (HP:0006572)2.44423366
39Recurrent viral infections (HP:0004429)2.44375688
40Epistaxis (HP:0000421)2.40069110
41Encephalitis (HP:0002383)2.38024224
42Peritonitis (HP:0002586)2.36908095
43Colitis (HP:0002583)2.36576679
44Obstructive lung disease (HP:0006536)2.35197714
45Chronic obstructive pulmonary disease (HP:0006510)2.35197714
46Inflammation of the large intestine (HP:0002037)2.31724930
47Viral hepatitis (HP:0006562)2.31083781
48Gastrointestinal inflammation (HP:0004386)2.29592277
49Postural instability (HP:0002172)2.27080904
50Panhypogammaglobulinemia (HP:0003139)2.23595274
51Pustule (HP:0200039)2.21253236
52Keratoconjunctivitis (HP:0001096)2.19391328
53Pulmonary infiltrates (HP:0002113)2.17003654
54Hemoptysis (HP:0002105)2.12391002
55Osteomyelitis (HP:0002754)2.11802038
56Leukocytosis (HP:0001974)2.11087953
57Arterial thrombosis (HP:0004420)2.11006393
58Urticaria (HP:0001025)2.10843686
59Pulmonary embolism (HP:0002204)2.07900318
60Hypochromic anemia (HP:0001931)2.07787213
61Agammaglobulinemia (HP:0004432)2.05240928
62Ankle clonus (HP:0011448)1.99457816
63Hemiplegia (HP:0002301)1.99171377
64Abnormality of T cells (HP:0002843)1.96515151
65Abnormality of the peritoneum (HP:0002585)1.94107847
66Diplopia (HP:0000651)1.93501714
67Abnormality of binocular vision (HP:0011514)1.93501714
68Microcytic anemia (HP:0001935)1.91238960
69Granulocytopenia (HP:0001913)1.87578199
70Supranuclear gaze palsy (HP:0000605)1.86864224
71Cerebral inclusion bodies (HP:0100314)1.86493002
72Papilloma (HP:0012740)1.84535964
73Verrucae (HP:0200043)1.84535964
74Recurrent bronchitis (HP:0002837)1.83295602
75Muscle fiber splitting (HP:0003555)1.82618842
76Papillary thyroid carcinoma (HP:0002895)1.81970277
77Macroorchidism (HP:0000053)1.79684478
78Sepsis (HP:0100806)1.72621924
79Eosinophilia (HP:0001880)1.71700537
80Episodic fever (HP:0001954)1.70693370
81Autoimmune hemolytic anemia (HP:0001890)1.70431877
82Ocular albinism (HP:0001107)1.68543107
83Genetic anticipation (HP:0003743)1.67624374
84Onion bulb formation (HP:0003383)1.66874577
85Amyloidosis (HP:0011034)1.66686340
86Gastrointestinal stroma tumor (HP:0100723)1.65249493
87Polycythemia (HP:0001901)1.63663109
88Abnormal platelet volume (HP:0011876)1.63616216
89Neonatal hypoglycemia (HP:0001998)1.63526545
90Abnormality of the endocardium (HP:0004306)1.60956459
91Segmental peripheral demyelination/remyelination (HP:0003481)1.60748841
92Visual hallucinations (HP:0002367)1.60039312
93Lower limb asymmetry (HP:0100559)1.55454310
94Dislocated radial head (HP:0003083)1.55444327
95Restrictive lung disease (HP:0002091)1.55363262
96Dysmetric saccades (HP:0000641)1.54553709
97Cerebral aneurysm (HP:0004944)1.54159507
98Lymphopenia (HP:0001888)1.53951459
99Germ cell neoplasia (HP:0100728)1.53903305
100Neurofibrillary tangles (HP:0002185)1.53643167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.10574008
2PRPF4B2.89135310
3MAP4K12.44484828
4BLK2.16119517
5TYK22.08803762
6FES1.98987724
7MAP2K31.82963215
8ERN11.82138422
9CSK1.79836570
10FGFR31.74926786
11MARK21.67845127
12MAP3K131.62064190
13SGK21.60670293
14WNK11.56084531
15KSR21.55934546
16JAK11.55922244
17SGK31.54789449
18GRK61.54318297
19ZAP701.46765417
20JAK31.44387068
21CDK121.43260762
22IRAK41.43040643
23EPHB11.42199026
24BTK1.41202200
25FGFR41.40387098
26TNK21.39189852
27SYK1.38580400
28SIK21.38410105
29MAP3K21.34942494
30FGR1.34537705
31MAP3K141.34160401
32HCK1.33750108
33IKBKE1.30105631
34TRIB31.25644401
35RIPK11.23868371
36MAP3K71.20707599
37JAK21.20071316
38SGK2231.16845242
39SGK4941.16845242
40YES11.16489861
41MAP3K11.15901985
42CAMKK11.15685337
43TXK1.14563551
44ITK1.12194728
45SIK31.05503341
46TAOK11.04897701
47TAOK30.99948829
48NLK0.99849699
49STK380.99402835
50PDK10.95012207
51BMPR20.94113347
52RET0.93985885
53NTRK30.93921007
54MAPK120.92076936
55LYN0.91107540
56CDC42BPA0.90283787
57MAP3K30.89743426
58HIPK20.87617255
59LCK0.86815644
60BRD40.85294677
61STK110.84960622
62MAP3K100.83478343
63MAP3K60.81944674
64DAPK20.81299298
65CAMKK20.80226524
66PTK2B0.80157280
67MARK30.79324092
68KSR10.78572531
69TEC0.78252530
70IRAK20.75500243
71CSF1R0.75026434
72PDPK10.73525175
73MAPK70.73133306
74SGK10.72832204
75UHMK10.72308181
76KIT0.71001862
77AKT30.70073606
78CAMK40.69443274
79PIK3CG0.69427991
80PDGFRB0.68641599
81PRKCH0.67463825
82CAMK1G0.67192274
83CAMK1D0.66849660
84PRKD20.66370815
85LRRK20.66349912
86SIK10.65642607
87FYN0.65351345
88TYRO30.63649430
89IRAK10.59907143
90EPHA30.59519529
91DYRK1A0.55911632
92MAP3K110.53535662
93TBK10.52817067
94TRPM70.52202695
95PTK60.52146259
96DYRK1B0.50797042
97GRK50.48882895
98PAK60.48595308
99CAMK10.48555118
100ICK0.47205875

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.21374291
2Osteoclast differentiation_Homo sapiens_hsa043802.00506854
3Leishmaniasis_Homo sapiens_hsa051401.89408215
4Non-small cell lung cancer_Homo sapiens_hsa052231.72419045
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71933640
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68134902
7T cell receptor signaling pathway_Homo sapiens_hsa046601.66147204
8Acute myeloid leukemia_Homo sapiens_hsa052211.65193032
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58397761
10Staphylococcus aureus infection_Homo sapiens_hsa051501.53041885
11Long-term potentiation_Homo sapiens_hsa047201.48649180
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45741424
13Tuberculosis_Homo sapiens_hsa051521.43752773
14Dorso-ventral axis formation_Homo sapiens_hsa043201.38243744
15Chronic myeloid leukemia_Homo sapiens_hsa052201.35806743
16VEGF signaling pathway_Homo sapiens_hsa043701.32144056
17Chemokine signaling pathway_Homo sapiens_hsa040621.30510284
18Renal cell carcinoma_Homo sapiens_hsa052111.30335922
19Pancreatic cancer_Homo sapiens_hsa052121.29834099
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29328920
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.28264417
22Measles_Homo sapiens_hsa051621.25934841
23Platelet activation_Homo sapiens_hsa046111.22237227
24Endometrial cancer_Homo sapiens_hsa052131.21928640
25mTOR signaling pathway_Homo sapiens_hsa041501.17895228
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.17109125
27Toxoplasmosis_Homo sapiens_hsa051451.15210908
28Prolactin signaling pathway_Homo sapiens_hsa049171.14979961
29Inositol phosphate metabolism_Homo sapiens_hsa005621.14716212
30Graft-versus-host disease_Homo sapiens_hsa053321.14521803
31Choline metabolism in cancer_Homo sapiens_hsa052311.14407049
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.14387656
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14265924
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12623058
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.12558140
36GnRH signaling pathway_Homo sapiens_hsa049121.11770323
37Allograft rejection_Homo sapiens_hsa053301.10273873
38Autoimmune thyroid disease_Homo sapiens_hsa053201.10089450
39Glioma_Homo sapiens_hsa052141.09927599
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08226717
41ErbB signaling pathway_Homo sapiens_hsa040121.08028241
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.07674366
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07523898
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07190822
45Influenza A_Homo sapiens_hsa051641.05281081
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04896236
47Primary immunodeficiency_Homo sapiens_hsa053401.04313651
48Hepatitis B_Homo sapiens_hsa051611.04209584
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03873056
50FoxO signaling pathway_Homo sapiens_hsa040681.02940874
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97960638
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97928714
53Hepatitis C_Homo sapiens_hsa051600.97555016
54Hematopoietic cell lineage_Homo sapiens_hsa046400.96872775
55Malaria_Homo sapiens_hsa051440.96600679
56Notch signaling pathway_Homo sapiens_hsa043300.95199534
57TNF signaling pathway_Homo sapiens_hsa046680.93393307
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91696394
59Type II diabetes mellitus_Homo sapiens_hsa049300.90123590
60Estrogen signaling pathway_Homo sapiens_hsa049150.87966988
61Type I diabetes mellitus_Homo sapiens_hsa049400.85817955
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.82840861
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81388700
64Insulin resistance_Homo sapiens_hsa049310.79234607
65Cholinergic synapse_Homo sapiens_hsa047250.78848680
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78651839
67Colorectal cancer_Homo sapiens_hsa052100.78433190
68Viral myocarditis_Homo sapiens_hsa054160.77547297
69Prostate cancer_Homo sapiens_hsa052150.75657087
70MAPK signaling pathway_Homo sapiens_hsa040100.75236415
71Herpes simplex infection_Homo sapiens_hsa051680.73736758
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.73238539
73Oxytocin signaling pathway_Homo sapiens_hsa049210.72987305
74Endocytosis_Homo sapiens_hsa041440.72007492
75Insulin signaling pathway_Homo sapiens_hsa049100.70028931
76Amoebiasis_Homo sapiens_hsa051460.69451705
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68989227
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68506323
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67830117
80HIF-1 signaling pathway_Homo sapiens_hsa040660.66486540
81Long-term depression_Homo sapiens_hsa047300.64814177
82Gastric acid secretion_Homo sapiens_hsa049710.64761647
83Renin secretion_Homo sapiens_hsa049240.64263203
84Amphetamine addiction_Homo sapiens_hsa050310.63942016
85Rap1 signaling pathway_Homo sapiens_hsa040150.63737797
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63679885
87African trypanosomiasis_Homo sapiens_hsa051430.61805974
88Phagosome_Homo sapiens_hsa041450.61721382
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60202750
90Apoptosis_Homo sapiens_hsa042100.59797235
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.59673999
92Antigen processing and presentation_Homo sapiens_hsa046120.59277255
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59241317
94Ras signaling pathway_Homo sapiens_hsa040140.59002458
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58990901
96cAMP signaling pathway_Homo sapiens_hsa040240.58836251
97Other glycan degradation_Homo sapiens_hsa005110.56030412
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55571469
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54002174
100Circadian rhythm_Homo sapiens_hsa047100.53762092

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