ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium movement (GO:0003341)	9.48380369
2	motile cilium assembly (GO:0044458)	8.79111260
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	8.28734337
4	epithelial cilium movement (GO:0003351)	8.14739405
5	left/right pattern formation (GO:0060972)	5.45700977
6	axoneme assembly (GO:0035082)	5.38295265
7	ventricular system development (GO:0021591)	4.89292498
8	glomerular epithelial cell development (GO:0072310)	4.32732436
9	primary alcohol catabolic process (GO:0034310)	4.27948673
10	vitamin transmembrane transport (GO:0035461)	4.10982669
11	lung epithelium development (GO:0060428)	3.86398454
12	tolerance induction (GO:0002507)	3.86240179
13	regulation of cilium movement (GO:0003352)	3.86163195
14	positive regulation of histone deacetylation (GO:0031065)	3.83714070
15	insulin-like growth factor receptor signaling pathway (GO:0048009)	3.81888850
16	left/right axis specification (GO:0070986)	3.67263344
17	ethanol metabolic process (GO:0006067)	3.58440658
18	centriole assembly (GO:0098534)	3.52440967
19	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.48436660
20	negative regulation of B cell mediated immunity (GO:0002713)	3.48436660
21	establishment of apical/basal cell polarity (GO:0035089)	3.47685476
22	diterpenoid biosynthetic process (GO:0016102)	3.44925192
23	cellular extravasation (GO:0045123)	3.43724082
24	microtubule bundle formation (GO:0001578)	3.41740094
25	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	3.35081675
26	negative regulation of humoral immune response (GO:0002921)	3.35057332
27	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.33234643
28	regulation of interleukin-5 production (GO:0032674)	3.28133848
29	reactive oxygen species biosynthetic process (GO:1903409)	3.23772814
30	N-acetylneuraminate metabolic process (GO:0006054)	3.10875306
31	positive regulation of tolerance induction (GO:0002645)	3.03833563
32	cilium organization (GO:0044782)	3.03494490
33	response to xenobiotic stimulus (GO:0009410)	3.01341688
34	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.99142023
35	cilium assembly (GO:0042384)	2.97804456
36	regulation of interleukin-13 production (GO:0032656)	2.97440292
37	positive regulation of protein deacetylation (GO:0090312)	2.95264404
38	intraciliary transport (GO:0042073)	2.82620317
39	regulation of germinal center formation (GO:0002634)	2.80465900
40	hypotonic response (GO:0006971)	2.80075589
41	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.77680638
42	establishment of monopolar cell polarity (GO:0061162)	2.77680638
43	regulation of tolerance induction (GO:0002643)	2.72795519
44	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	2.72413415
45	histone H3-K36 demethylation (GO:0070544)	2.70702141
46	negative regulation of T cell differentiation in thymus (GO:0033085)	2.66772047
47	one-carbon compound transport (GO:0019755)	2.64701898
48	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.64512774
49	positive regulation of smoothened signaling pathway (GO:0045880)	2.62624871
50	hydrogen peroxide biosynthetic process (GO:0050665)	2.62379271
51	negative regulation of inclusion body assembly (GO:0090084)	2.60875005
52	microtubule-based movement (GO:0007018)	2.56948479
53	sperm capacitation (GO:0048240)	2.56791678
54	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.53434157
55	semaphorin-plexin signaling pathway (GO:0071526)	2.52869644
56	centriole replication (GO:0007099)	2.49396704
57	iron ion import (GO:0097286)	2.46090120
58	multicellular organismal water homeostasis (GO:0050891)	2.45741523
59	ear development (GO:0043583)	2.44801012
60	microglial cell activation (GO:0001774)	2.42262830
61	regulation of ARF protein signal transduction (GO:0032012)	2.38612811
62	cell projection assembly (GO:0030031)	2.38594177
63	cellular component assembly involved in morphogenesis (GO:0010927)	2.37245813
64	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.36862579
65	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.35055943
66	filopodium assembly (GO:0046847)	2.34408289
67	protein localization to cilium (GO:0061512)	2.32977190
68	polyol transport (GO:0015791)	2.29588236
69	regulation of microtubule-based movement (GO:0060632)	2.29385164
70	regulation of cilium assembly (GO:1902017)	2.29274082
71	establishment of planar polarity (GO:0001736)	2.28572582
72	establishment of tissue polarity (GO:0007164)	2.28572582
73	O-glycan processing (GO:0016266)	2.28135557
74	neutrophil mediated immunity (GO:0002446)	2.22771569
75	germinal center formation (GO:0002467)	2.21317600
76	ethanol oxidation (GO:0006069)	2.20116575
77	phosphatidylethanolamine metabolic process (GO:0046337)	2.19031624
78	water homeostasis (GO:0030104)	2.18623668
79	regulation of histone deacetylation (GO:0031063)	2.18154643
80	mannose metabolic process (GO:0006013)	2.17202876
81	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.16714973
82	negative regulation of toll-like receptor signaling pathway (GO:0034122)	2.16490268
83	signal complex assembly (GO:0007172)	2.15031621
84	embryonic camera-type eye development (GO:0031076)	2.14988910
85	regulation of apoptotic cell clearance (GO:2000425)	2.14746356
86	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	2.14260237
87	negative regulation of lymphocyte mediated immunity (GO:0002707)	2.14089010
88	amino sugar catabolic process (GO:0046348)	2.13378874
89	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.12975233
90	striated muscle atrophy (GO:0014891)	2.11888489
91	regulation of ARF GTPase activity (GO:0032312)	2.10379038
92	cell-cell junction maintenance (GO:0045217)	2.09005294
93	macroautophagy (GO:0016236)	2.08499402
94	regulation of response to osmotic stress (GO:0047484)	2.06573650
95	cytoplasmic microtubule organization (GO:0031122)	2.06372377
96	histone lysine demethylation (GO:0070076)	2.05010984
97	retinoic acid metabolic process (GO:0042573)	2.03792756
98	cilium morphogenesis (GO:0060271)	2.03691948
99	axonemal dynein complex assembly (GO:0070286)	12.2629887
100	cilium or flagellum-dependent cell motility (GO:0001539)	10.8622110

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.01445575
2	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.96902883
3	DROSHA_22980978_ChIP-Seq_HELA_Human	2.84402317
4	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.65844071
5	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.37452762
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.27381059
7	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.08432280
8	RUNX1_27514584_Chip-Seq_MCF-7_Human	2.05911768
9	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.02832701
10	LXR_22292898_ChIP-Seq_THP-1_Human	1.93989845
11	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.93758496
12	SMC4_20622854_ChIP-Seq_HELA_Human	1.91514300
13	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.82841044
14	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.81757530
15	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.76948529
16	RACK7_27058665_Chip-Seq_MCF-7_Human	1.71721458
17	* AHR_22903824_ChIP-Seq_MCF-7_Human	1.68484776
18	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.64090421
19	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.63053956
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.60264606
21	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.59813408
22	KDM2B_26808549_Chip-Seq_K562_Human	1.54406882
23	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.54281175
24	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.52518474
25	TCF7_22412390_ChIP-Seq_EML_Mouse	1.51096653
26	VDR_21846776_ChIP-Seq_THP-1_Human	1.49967632
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.47688721
28	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.45790967
29	CREB1_26743006_Chip-Seq_LNCaP_Human	1.42727351
30	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.42422362
31	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.41944281
32	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.40778550
33	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.40387196
34	GATA1_19941826_ChIP-Seq_K562_Human	1.40253040
35	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.39123182
36	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.38466887
37	VDR_24763502_ChIP-Seq_THP-1_Human	1.36811269
38	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36762073
39	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.35168672
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.33272134
41	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.32976478
42	SPI1_23127762_ChIP-Seq_K562_Human	1.32044825
43	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.31800216
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.30068621
45	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.29121448
46	* FOXA2_19822575_ChIP-Seq_HepG2_Human	1.28638393
47	KDM2B_26808549_Chip-Seq_DND41_Human	1.28236807
48	P68_20966046_ChIP-Seq_HELA_Human	1.28206805
49	KLF5_25053715_ChIP-Seq_YYC3_Human	1.26925486
50	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.26373977
51	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.25791809
52	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.25315699
53	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.25244209
54	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.23854925
55	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.22976571
56	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.20539136
57	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.20339984
58	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.20094799
59	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.18955152
60	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.15167350
61	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14263462
62	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.14070507
63	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.13443894
64	SCL_19346495_ChIP-Seq_HPC-7_Human	1.13066554
65	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.13042497
66	TP53_22127205_ChIP-Seq_IMR90_Human	1.11299250
67	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.09746636
68	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.07570794
69	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.06318749
70	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.05481958
71	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.05406243
72	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00500821
73	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.99455606
74	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.99400012
75	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.97393610
76	CTCF_27219007_Chip-Seq_Bcells_Human	0.97096912
77	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.95946305
78	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.94896425
79	* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.94557470
80	MAF_26560356_Chip-Seq_TH1_Human	0.94444500
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93553008
82	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.92036863
83	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.92036863
84	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.91482011
85	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.90514552
86	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.90003529
87	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.89147427
88	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.88564859
89	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.88330871
90	RUNX_20019798_ChIP-Seq_JUKART_Human	0.87930491
91	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.87914654
92	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.87875147
93	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.87873915
94	OCT4_19829295_ChIP-Seq_ESCs_Human	0.87722876
95	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.87400563
96	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.87247721
97	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.87206040
98	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.86596066
99	* GATA2_19941826_ChIP-Seq_K562_Human	0.86012915
100	BCOR_27268052_Chip-Seq_Bcells_Human	0.86008212

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005083_abnormal_biliary_tract	4.72336756
2	MP0002653_abnormal_ependyma_morphology	3.83585641
3	MP0008875_abnormal_xenobiotic_pharmacok	3.55652290
4	MP0004043_abnormal_pH_regulation	3.55280858
5	MP0002132_abnormal_respiratory_system	3.29063979
6	MP0000383_abnormal_hair_follicle	2.52239033
7	MP0003705_abnormal_hypodermis_morpholog	2.32815632
8	MP0008961_abnormal_basal_metabolism	2.32707866
9	MP0003878_abnormal_ear_physiology	2.29769506
10	MP0005377_hearing/vestibular/ear_phenot	2.29769506
11	MP0005076_abnormal_cell_differentiation	2.15408762
12	MP0010678_abnormal_skin_adnexa	2.07858364
13	MP0005365_abnormal_bile_salt	1.97347628
14	MP0003172_abnormal_lysosome_physiology	1.95927435
15	MP0002277_abnormal_respiratory_mucosa	1.92395421
16	MP0009780_abnormal_chondrocyte_physiolo	1.91067198
17	MP0003566_abnormal_cell_adhesion	1.85637031
18	MP0002168_other_aberrant_phenotype	1.81827355
19	MP0003191_abnormal_cellular_cholesterol	1.78353552
20	MP0003303_peritoneal_inflammation	1.75963399
21	MP0001984_abnormal_olfaction	1.73859448
22	MP0002249_abnormal_larynx_morphology	1.70982594
23	MP0003091_abnormal_cell_migration	1.70454049
24	MP0005409_darkened_coat_color	1.69758879
25	MP0003436_decreased_susceptibility_to	1.61930045
26	MP0005310_abnormal_salivary_gland	1.61806554
27	MP0005248_abnormal_Harderian_gland	1.54136367
28	MP0004858_abnormal_nervous_system	1.53769079
29	MP0004947_skin_inflammation	1.53447247
30	MP0004133_heterotaxia	1.52848433
31	MP0004264_abnormal_extraembryonic_tissu	1.52322066
32	MP0001849_ear_inflammation	1.51247029
33	MP0001765_abnormal_ion_homeostasis	1.51101314
34	MP0001958_emphysema	1.48942475
35	MP0005623_abnormal_meninges_morphology	1.46233202
36	MP0010234_abnormal_vibrissa_follicle	1.42533953
37	MP0004381_abnormal_hair_follicle	1.39000215
38	MP0000566_synostosis	1.37274407
39	MP0010155_abnormal_intestine_physiology	1.32547846
40	MP0002098_abnormal_vibrissa_morphology	1.31086043
41	MP0003453_abnormal_keratinocyte_physiol	1.30302703
42	MP0003183_abnormal_peptide_metabolism	1.29795648
43	MP0004019_abnormal_vitamin_homeostasis	1.24314512
44	MP0005164_abnormal_response_to	1.22927149
45	MP0003045_fibrosis	1.22620254
46	MP0002419_abnormal_innate_immunity	1.20584621
47	MP0005058_abnormal_lysosome_morphology	1.16354263
48	MP0009278_abnormal_bone_marrow	1.15859548
49	MP0003252_abnormal_bile_duct	1.15661715
50	MP0001502_abnormal_circadian_rhythm	1.14266083
51	MP0009384_cardiac_valve_regurgitation	1.10672843
52	MP0003656_abnormal_erythrocyte_physiolo	1.09266735
53	MP0005503_abnormal_tendon_morphology	1.09052392
54	MP0003866_abnormal_defecation	1.08571743
55	MP0002405_respiratory_system_inflammati	1.04548848
56	MP0000003_abnormal_adipose_tissue	1.03236351
57	MP0000465_gastrointestinal_hemorrhage	1.02203756
58	MP0005085_abnormal_gallbladder_physiolo	1.00788753
59	MP0000678_abnormal_parathyroid_gland	1.00741541
60	MP0004883_abnormal_blood_vessel	0.99749458
61	MP0002909_abnormal_adrenal_gland	0.99671356
62	MP0009643_abnormal_urine_homeostasis	0.98783749
63	MP0005025_abnormal_response_to	0.97973719
64	MP0009115_abnormal_fat_cell	0.96858291
65	MP0001270_distended_abdomen	0.96544332
66	MP0002136_abnormal_kidney_physiology	0.95790777
67	MP0003828_pulmonary_edema	0.94918420
68	MP0005023_abnormal_wound_healing	0.93857199
69	MP0005387_immune_system_phenotype	0.92230579
70	MP0001790_abnormal_immune_system	0.92230579
71	MP0005375_adipose_tissue_phenotype	0.90027104
72	MP0003300_gastrointestinal_ulcer	0.89489809
73	MP0002896_abnormal_bone_mineralization	0.88413985
74	MP0003724_increased_susceptibility_to	0.85564667
75	MP0002282_abnormal_trachea_morphology	0.84555786
76	MP0003279_aneurysm	0.83106637
77	MP0001533_abnormal_skeleton_physiology	0.81943455
78	MP0000249_abnormal_blood_vessel	0.78452295
79	MP0003690_abnormal_glial_cell	0.78113617
80	MP0000467_abnormal_esophagus_morphology	0.76615674
81	MP0000681_abnormal_thyroid_gland	0.76472221
82	MP0002998_abnormal_bone_remodeling	0.76092352
83	MP0002108_abnormal_muscle_morphology	0.75015348
84	MP0005451_abnormal_body_composition	0.74482718
85	MP0002089_abnormal_postnatal_growth/wei	0.74252954
86	MP0003329_amyloid_beta_deposits	0.72297232
87	MP0001664_abnormal_digestion	0.71526841
88	MP0001873_stomach_inflammation	0.68637581
89	MP0002133_abnormal_respiratory_system	0.67819233
90	MP0005388_respiratory_system_phenotype	0.67819233
91	MP0005670_abnormal_white_adipose	0.67238188
92	MP0000858_altered_metastatic_potential	0.65355058
93	MP0005666_abnormal_adipose_tissue	0.63944329
94	MP0002060_abnormal_skin_morphology	0.63851703
95	MP0003075_altered_response_to	0.63329688
96	MP0002796_impaired_skin_barrier	0.62701210
97	MP0008260_abnormal_autophagy	0.61591737
98	MP0006082_CNS_inflammation	0.60690267
99	MP0003115_abnormal_respiratory_system	0.60469286
100	MP0001348_abnormal_lacrimal_gland	0.59155444

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	9.86504499
2	Abnormal respiratory epithelium morphology (HP:0012253)	9.03082615
3	Abnormal respiratory motile cilium morphology (HP:0005938)	9.03082615
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.85449353
5	Absent/shortened dynein arms (HP:0200106)	8.85449353
6	Abnormal ciliary motility (HP:0012262)	8.79079013
7	Abnormal respiratory motile cilium physiology (HP:0012261)	8.70761122
8	Rhinitis (HP:0012384)	8.04331744
9	Bronchiectasis (HP:0002110)	6.03142288
10	Nasal polyposis (HP:0100582)	6.01738175
11	Chronic bronchitis (HP:0004469)	5.88460264
12	Abnormality of the nasal mucosa (HP:0000433)	5.11246365
13	Recurrent sinusitis (HP:0011108)	3.68935495
14	Recurrent otitis media (HP:0000403)	3.58296254
15	Bronchitis (HP:0012387)	3.47352694
16	Infertility (HP:0000789)	3.41127034
17	Male infertility (HP:0003251)	3.30976091
18	Atelectasis (HP:0100750)	3.03852744
19	Chronic sinusitis (HP:0011109)	3.01865373
20	Occipital encephalocele (HP:0002085)	2.92704990
21	Obstructive sleep apnea (HP:0002870)	2.70348092
22	Hyperactive renin-angiotensin system (HP:0000841)	2.65638131
23	Bell-shaped thorax (HP:0001591)	2.47628840
24	Absent frontal sinuses (HP:0002688)	2.34138889
25	Cystic liver disease (HP:0006706)	2.32390521
26	Short nail (HP:0001799)	2.29249802
27	Flat acetabular roof (HP:0003180)	2.29205850
28	Broad face (HP:0000283)	2.17449270
29	Chronic otitis media (HP:0000389)	2.10166469
30	Hyperkalemia (HP:0002153)	2.06707155
31	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.03231593
32	Cervical subluxation (HP:0003308)	2.02777236
33	Tubulointerstitial nephritis (HP:0001970)	2.02360193
34	True hermaphroditism (HP:0010459)	1.98106595
35	Pancreatic fibrosis (HP:0100732)	1.91109284
36	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.88925108
37	Nephronophthisis (HP:0000090)	1.87319102
38	Recurrent bronchitis (HP:0002837)	1.81591239
39	Postaxial foot polydactyly (HP:0001830)	1.75899697
40	Molar tooth sign on MRI (HP:0002419)	1.75652591
41	Abnormality of midbrain morphology (HP:0002418)	1.75652591
42	Abnormality of chloride homeostasis (HP:0011422)	1.72742013
43	Renal salt wasting (HP:0000127)	1.68603944
44	Chronic hepatic failure (HP:0100626)	1.62060244
45	Abnormality of dentin (HP:0010299)	1.58025226
46	Decreased circulating renin level (HP:0003351)	1.57639775
47	Abnormality of the renal medulla (HP:0100957)	1.57188678
48	Eczematoid dermatitis (HP:0000976)	1.57031944
49	Abnormal vertebral ossification (HP:0100569)	1.56420459
50	Congenital hepatic fibrosis (HP:0002612)	1.55768682
51	Hyperaldosteronism (HP:0000859)	1.54512349
52	Tubular atrophy (HP:0000092)	1.54133155
53	Abnormality of permanent molar morphology (HP:0011071)	1.53940181
54	Abnormality of the dental root (HP:0006486)	1.53940181
55	Taurodontia (HP:0000679)	1.53940181
56	Abnormality of the frontal sinuses (HP:0002687)	1.50130311
57	Hand muscle atrophy (HP:0009130)	1.49230037
58	Myositis (HP:0100614)	1.47801220
59	Abnormality of molar morphology (HP:0011070)	1.47762949
60	Abnormality of molar (HP:0011077)	1.47762949
61	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.46112588
62	Interstitial pulmonary disease (HP:0006530)	1.44525530
63	Abnormality of the dental pulp (HP:0006479)	1.43385668
64	Lip pit (HP:0100267)	1.42622173
65	Stage 5 chronic kidney disease (HP:0003774)	1.42473140
66	Arterial tortuosity (HP:0005116)	1.42454998
67	Upper limb amyotrophy (HP:0009129)	1.42021658
68	Distal upper limb amyotrophy (HP:0007149)	1.42021658
69	Self-mutilation (HP:0000742)	1.38060302
70	Recurrent bacterial skin infections (HP:0005406)	1.37975900
71	Mucopolysacchariduria (HP:0008155)	1.37410704
72	Urinary glycosaminoglycan excretion (HP:0003541)	1.37410704
73	Short thorax (HP:0010306)	1.37202522
74	Epiphyseal dysplasia (HP:0002656)	1.36730827
75	Pancreatic cysts (HP:0001737)	1.36597623
76	Neoplasm of the heart (HP:0100544)	1.35815390
77	Hypoplasia of the odontoid process (HP:0003311)	1.35748924
78	Bronchomalacia (HP:0002780)	1.31596797
79	Recurrent abscess formation (HP:0002722)	1.30170024
80	Hypokalemic alkalosis (HP:0001949)	1.29763693
81	Abnormality of the distal phalanges of the toes (HP:0010182)	1.29587956
82	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.29335353
83	Abnormality of polysaccharide metabolism (HP:0011012)	1.29335353
84	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.29335353
85	Spinal cord compression (HP:0002176)	1.28201141
86	Aneurysm (HP:0002617)	1.27929709
87	Abnormality of renin-angiotensin system (HP:0000847)	1.27415211
88	Stridor (HP:0010307)	1.27187187
89	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.25950424
90	Glucose intolerance (HP:0000833)	1.25198888
91	Hemorrhage of the eye (HP:0011885)	1.24495744
92	Absent speech (HP:0001344)	1.24149184
93	Gingivitis (HP:0000230)	1.23954481
94	Nephropathy (HP:0000112)	1.23896633
95	Vascular tortuosity (HP:0004948)	1.23722930
96	Abnormality of the odontoid process (HP:0003310)	1.22826246
97	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.22436316
98	Recurrent gram-negative bacterial infections (HP:0005420)	1.21943128
99	Mitral stenosis (HP:0001718)	1.21463096
100	Distal lower limb muscle weakness (HP:0009053)	1.20787656

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.37521903
2	TRIB3	4.25964683
3	SMG1	3.09040862
4	EPHA2	3.00772854
5	ERN1	2.57409747
6	CAMK1D	2.39694478
7	ICK	2.29635496
8	NEK2	2.12703854
9	MARK2	2.10199773
10	CCNB1	2.06491442
11	CAMK1G	1.99898905
12	EPHB1	1.91566793
13	EEF2K	1.88724089
14	MAP3K7	1.78382753
15	CDK12	1.68698211
16	RIPK1	1.64975240
17	SIK1	1.62080901
18	CSK	1.56684271
19	RIPK4	1.52530874
20	CAMKK1	1.52516145
21	MAP3K2	1.43775329
22	MST1R	1.43291090
23	CAMKK2	1.43020205
24	LRRK2	1.41325930
25	PKN2	1.37710170
26	MAP3K3	1.28869626
27	TNK2	1.26451213
28	PTK2B	1.19456195
29	FGFR4	1.18109815
30	PRKD2	1.15997017
31	CDC42BPA	1.11690187
32	STK38	1.10679698
33	CHUK	1.09358833
34	BLK	1.06092455
35	HIPK2	1.04243776
36	MAP2K3	1.03522130
37	TAOK1	0.99287027
38	GRK6	0.98189028
39	TYK2	0.97332519
40	PDPK1	0.94313500
41	RET	0.92577909
42	PRPF4B	0.92402645
43	WNK4	0.90938582
44	PDGFRB	0.90864580
45	ZAP70	0.90431543
46	TBK1	0.88865704
47	PTK6	0.87295163
48	EPHA3	0.87141827
49	MET	0.85388905
50	MTOR	0.85043352
51	FGFR3	0.84938604
52	NEK9	0.82979449
53	NEK6	0.82308431
54	MAPKAPK3	0.82191884
55	ERBB2	0.78101346
56	WNK1	0.75761808
57	RPS6KA2	0.75120218
58	TRPM7	0.74706200
59	KSR2	0.72260245
60	PRKAA2	0.70758696
61	TESK1	0.69368396
62	SGK3	0.68335858
63	MAP3K1	0.65879976
64	MAP2K4	0.63674600
65	IRAK4	0.61264178
66	MAP4K1	0.60539725
67	MAP2K2	0.59992662
68	PDK1	0.59786409
69	MAP3K6	0.58334938
70	MAP3K11	0.57989255
71	JAK1	0.56820668
72	PTK2	0.56162014
73	BTK	0.53554952
74	HCK	0.53290824
75	SGK2	0.51591125
76	MELK	0.48396379
77	DYRK1B	0.46767737
78	RPS6KL1	0.46156439
79	RPS6KC1	0.46156439
80	CAMK4	0.46021925
81	PRKD3	0.43516365
82	FGR	0.43137415
83	PDGFRA	0.42919720
84	FES	0.42737918
85	TTN	0.41653554
86	RPS6KA6	0.41447469
87	SIK2	0.40499950
88	STK24	0.40325405
89	SGK1	0.39970026
90	CAMK1	0.39812908
91	PAK4	0.38932738
92	PRKCH	0.38618700
93	MAP3K13	0.38459767
94	SGK223	0.38046940
95	SGK494	0.38046940
96	PRKD1	0.37670594
97	MAPK7	0.37393532
98	LMTK2	0.37129239
99	FYN	0.36846472
100	PRKCI	0.36644759

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	2.50962861
2	Phenylalanine metabolism_Homo sapiens_hsa00360	1.87088094
3	Notch signaling pathway_Homo sapiens_hsa04330	1.81560364
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.67182428
5	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.54633298
6	Other glycan degradation_Homo sapiens_hsa00511	1.34967272
7	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.33193421
8	ABC transporters_Homo sapiens_hsa02010	1.32264793
9	Choline metabolism in cancer_Homo sapiens_hsa05231	1.24289060
10	Acute myeloid leukemia_Homo sapiens_hsa05221	1.21559492
11	Chemical carcinogenesis_Homo sapiens_hsa05204	1.20474819
12	Hepatitis C_Homo sapiens_hsa05160	1.18673903
13	Tyrosine metabolism_Homo sapiens_hsa00350	1.16873610
14	Amoebiasis_Homo sapiens_hsa05146	1.15915776
15	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.14770569
16	Osteoclast differentiation_Homo sapiens_hsa04380	1.12530837
17	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.12388794
18	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.12215188
19	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.10592813
20	Non-small cell lung cancer_Homo sapiens_hsa05223	1.09198999
21	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.08112112
22	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02411480
23	VEGF signaling pathway_Homo sapiens_hsa04370	1.01479481
24	Endometrial cancer_Homo sapiens_hsa05213	1.01421200
25	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.99917157
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99639982
27	Lysosome_Homo sapiens_hsa04142	0.99396868
28	mTOR signaling pathway_Homo sapiens_hsa04150	0.98542914
29	ErbB signaling pathway_Homo sapiens_hsa04012	0.96379011
30	GnRH signaling pathway_Homo sapiens_hsa04912	0.93904893
31	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.93837758
32	Insulin resistance_Homo sapiens_hsa04931	0.93238988
33	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.92770625
34	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.92653996
35	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.90141910
36	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89500786
37	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.89442298
38	ECM-receptor interaction_Homo sapiens_hsa04512	0.87463088
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85928175
40	Focal adhesion_Homo sapiens_hsa04510	0.85875374
41	Estrogen signaling pathway_Homo sapiens_hsa04915	0.85298672
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.84622953
43	Tight junction_Homo sapiens_hsa04530	0.83318515
44	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.83127929
45	Pancreatic cancer_Homo sapiens_hsa05212	0.83073449
46	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.82195566
47	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.82134945
48	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.82090137
49	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.80989912
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80477016
51	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.80265820
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.79602910
53	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.79356625
54	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79037132
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.78178334
56	TNF signaling pathway_Homo sapiens_hsa04668	0.77813061
57	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.76946804
58	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.76167316
59	Prostate cancer_Homo sapiens_hsa05215	0.76087250
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75642105
61	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.75434400
62	Prolactin signaling pathway_Homo sapiens_hsa04917	0.75405268
63	Renal cell carcinoma_Homo sapiens_hsa05211	0.75110566
64	Adherens junction_Homo sapiens_hsa04520	0.73832544
65	Tuberculosis_Homo sapiens_hsa05152	0.70771177
66	Type II diabetes mellitus_Homo sapiens_hsa04930	0.70645178
67	Influenza A_Homo sapiens_hsa05164	0.70332720
68	Axon guidance_Homo sapiens_hsa04360	0.69666481
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69195358
70	Leishmaniasis_Homo sapiens_hsa05140	0.68791440
71	Toxoplasmosis_Homo sapiens_hsa05145	0.68352577
72	Platelet activation_Homo sapiens_hsa04611	0.67989011
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67537942
74	Salivary secretion_Homo sapiens_hsa04970	0.67449893
75	Bladder cancer_Homo sapiens_hsa05219	0.66894133
76	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.66708826
77	Proteoglycans in cancer_Homo sapiens_hsa05205	0.66420020
78	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.66391367
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.66266465
80	FoxO signaling pathway_Homo sapiens_hsa04068	0.64250924
81	Malaria_Homo sapiens_hsa05144	0.62721707
82	Endocytosis_Homo sapiens_hsa04144	0.62564736
83	Chemokine signaling pathway_Homo sapiens_hsa04062	0.61422396
84	Small cell lung cancer_Homo sapiens_hsa05222	0.59448369
85	Phagosome_Homo sapiens_hsa04145	0.58618644
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58572735
87	Lysine degradation_Homo sapiens_hsa00310	0.57688074
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.57175984
89	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56834984
90	Thyroid cancer_Homo sapiens_hsa05216	0.56798939
91	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.56228704
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56166366
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.56030689
94	Glioma_Homo sapiens_hsa05214	0.55516794
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55236710
96	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.53071979
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.52230470
98	Apoptosis_Homo sapiens_hsa04210	0.51754898
99	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.51616921
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50331266

KIAA0556

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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