KIAA0753

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.26505411
2nuclear pore organization (GO:0006999)4.64279711
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.55861144
4epithelial cilium movement (GO:0003351)4.51682911
5cilium movement (GO:0003341)4.33553770
6axonemal dynein complex assembly (GO:0070286)4.19045615
7microtubule depolymerization (GO:0007019)4.11824938
8cilium or flagellum-dependent cell motility (GO:0001539)3.90704125
9protein localization to kinetochore (GO:0034501)3.86744372
10mitotic sister chromatid cohesion (GO:0007064)3.76942918
11pre-miRNA processing (GO:0031054)3.67596699
12protein localization to chromosome, centromeric region (GO:0071459)3.64327974
13paraxial mesoderm development (GO:0048339)3.64300110
14pore complex assembly (GO:0046931)3.53588066
15chromosome condensation (GO:0030261)3.44881729
16regulation of centriole replication (GO:0046599)3.39534270
17DNA packaging (GO:0006323)3.38973303
18intraciliary transport (GO:0042073)3.27018925
19centriole replication (GO:0007099)3.22354495
20heterochromatin organization (GO:0070828)3.22127892
21olfactory bulb development (GO:0021772)3.18513459
22mitotic chromosome condensation (GO:0007076)3.14924492
23microtubule polymerization or depolymerization (GO:0031109)3.07326515
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03891909
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.03891909
26regulation of translation, ncRNA-mediated (GO:0045974)3.03891909
27regulation of DNA endoreduplication (GO:0032875)3.02503789
28kinetochore organization (GO:0051383)3.00722706
29left/right pattern formation (GO:0060972)3.00373494
30single strand break repair (GO:0000012)2.99556301
31motile cilium assembly (GO:0044458)2.99346072
32metaphase plate congression (GO:0051310)2.96554868
33chromatin remodeling at centromere (GO:0031055)2.96329451
34mitotic metaphase plate congression (GO:0007080)2.94539519
35notochord development (GO:0030903)2.90920247
36histone exchange (GO:0043486)2.90124167
37axon extension involved in axon guidance (GO:0048846)2.89258556
38neuron projection extension involved in neuron projection guidance (GO:1902284)2.89258556
39sister chromatid cohesion (GO:0007062)2.88229432
40DNA replication-independent nucleosome organization (GO:0034724)2.84027668
41DNA replication-independent nucleosome assembly (GO:0006336)2.84027668
42CENP-A containing nucleosome assembly (GO:0034080)2.82982916
43lateral sprouting from an epithelium (GO:0060601)2.80016082
44protein localization to chromosome (GO:0034502)2.78671511
45centriole assembly (GO:0098534)2.75887873
46appendage development (GO:0048736)2.71579229
47limb development (GO:0060173)2.71579229
48double-strand break repair via nonhomologous end joining (GO:0006303)2.69585246
49non-recombinational repair (GO:0000726)2.69585246
50regulation of RNA export from nucleus (GO:0046831)2.68699962
51cilium assembly (GO:0042384)2.68445472
52ATP-dependent chromatin remodeling (GO:0043044)2.68166400
53regulation of cilium movement (GO:0003352)2.66544553
54cilium organization (GO:0044782)2.66171936
55spermatid nucleus differentiation (GO:0007289)2.63479267
56spermatid development (GO:0007286)2.61537837
57DNA double-strand break processing (GO:0000729)2.59626988
58nucleus organization (GO:0006997)2.59602681
59embryonic body morphogenesis (GO:0010172)2.57639583
60DNA topological change (GO:0006265)2.56955339
61lateral ventricle development (GO:0021670)2.55618151
62presynaptic membrane assembly (GO:0097105)2.55246615
63regulation of histone H3-K9 methylation (GO:0051570)2.54902134
64negative regulation of histone methylation (GO:0031061)2.53785734
65ventricular system development (GO:0021591)2.53214190
66DNA conformation change (GO:0071103)2.51935828
67sister chromatid segregation (GO:0000819)2.51931492
68meiotic chromosome segregation (GO:0045132)2.51302410
69planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51096810
70mitotic nuclear envelope disassembly (GO:0007077)2.49804703
71establishment of chromosome localization (GO:0051303)2.49017136
72establishment of planar polarity (GO:0001736)2.48586747
73establishment of tissue polarity (GO:0007164)2.48586747
74translesion synthesis (GO:0019985)2.48206114
75negative regulation of DNA repair (GO:0045738)2.47695567
76apical protein localization (GO:0045176)2.46394739
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44536377
78regulation of growth hormone secretion (GO:0060123)2.44525716
79kinetochore assembly (GO:0051382)2.43638598
80membrane disassembly (GO:0030397)2.40121922
81nuclear envelope disassembly (GO:0051081)2.40121922
82DNA replication checkpoint (GO:0000076)2.34949623
83mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.34547061
84establishment of integrated proviral latency (GO:0075713)2.32736884
85positive regulation of DNA-dependent DNA replication (GO:2000105)2.32583353
86neuronal stem cell maintenance (GO:0097150)2.32101712
87resolution of meiotic recombination intermediates (GO:0000712)2.31743958
88regulation of stem cell maintenance (GO:2000036)2.31583498
89mitotic sister chromatid segregation (GO:0000070)2.29953677
90binding of sperm to zona pellucida (GO:0007339)2.29156885
91protein-DNA complex disassembly (GO:0032986)2.29007912
92nucleosome disassembly (GO:0006337)2.29007912
93microtubule severing (GO:0051013)2.27937254
94microtubule-based movement (GO:0007018)2.27490630
95ncRNA catabolic process (GO:0034661)2.27071085
96regulation of centrosome duplication (GO:0010824)2.25884110
97protein polyglutamylation (GO:0018095)2.25820438
98regulation of NFAT protein import into nucleus (GO:0051532)2.25398497
99axonal fasciculation (GO:0007413)2.24967241
100regulation of sister chromatid cohesion (GO:0007063)2.24791835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.20490014
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.02059356
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.67378228
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.56988172
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.89038799
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87710212
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.82015367
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.81095532
9FUS_26573619_Chip-Seq_HEK293_Human2.66070452
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16448490
11EZH2_22144423_ChIP-Seq_EOC_Human2.07851643
12* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07203274
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.04485221
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.99607973
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96610452
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89258952
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76133125
18AR_21909140_ChIP-Seq_LNCAP_Human1.75919375
19TAF15_26573619_Chip-Seq_HEK293_Human1.73747488
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69944590
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66607272
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.64554453
23POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.64330933
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64330933
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63249254
26ZNF274_21170338_ChIP-Seq_K562_Hela1.56026109
27EWS_26573619_Chip-Seq_HEK293_Human1.54065171
28WT1_19549856_ChIP-ChIP_CCG9911_Human1.53293024
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51355461
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49078997
31CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48559000
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48006144
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47066113
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47046322
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45953621
36GBX2_23144817_ChIP-Seq_PC3_Human1.45662209
37P300_19829295_ChIP-Seq_ESCs_Human1.45342905
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45103564
39SMAD4_21799915_ChIP-Seq_A2780_Human1.44259042
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41447184
41CBP_20019798_ChIP-Seq_JUKART_Human1.40450583
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40450583
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38791938
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.38348868
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35442748
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.35121442
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33995773
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32267657
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30551384
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29546699
51ELK1_19687146_ChIP-ChIP_HELA_Human1.29493153
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26256633
53SOX9_26525672_Chip-Seq_HEART_Mouse1.26175858
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.25663788
55TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25564198
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23664684
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.22563252
58RNF2_27304074_Chip-Seq_NSC_Mouse1.21045144
59STAT3_23295773_ChIP-Seq_U87_Human1.20062237
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.19986311
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18241836
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18107316
63TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17783234
64TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17449534
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.17050934
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16452786
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15019012
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.14835697
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14664531
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11220968
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.11194502
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09838155
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09628235
74CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09303184
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09146109
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.08780513
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06690906
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05824462
79TP53_18474530_ChIP-ChIP_U2OS_Human1.05419860
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04218014
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01289614
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00535997
83RUNX2_22187159_ChIP-Seq_PCA_Human0.99922248
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99883770
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99377422
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98700719
87AR_25329375_ChIP-Seq_VCAP_Human0.97112295
88FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96819516
89POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96733934
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.96431436
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96110985
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96065580
93TCF4_23295773_ChIP-Seq_U87_Human0.93441928
94GF1B_26923725_Chip-Seq_HPCs_Mouse0.92465824
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92177812
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91002080
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89616967
98AHR_22903824_ChIP-Seq_MCF-7_Human0.89560269
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.88685626
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87596194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry2.88716900
2MP0010030_abnormal_orbit_morphology2.51055844
3MP0001293_anophthalmia2.49730795
4MP0000778_abnormal_nervous_system2.37935229
5MP0006292_abnormal_olfactory_placode2.12029087
6MP0003937_abnormal_limbs/digits/tail_de2.05277147
7MP0000566_synostosis2.04155573
8MP0003693_abnormal_embryo_hatching1.99646242
9MP0008877_abnormal_DNA_methylation1.97288120
10MP0010094_abnormal_chromosome_stability1.88008447
11MP0002084_abnormal_developmental_patter1.87396382
12MP0002233_abnormal_nose_morphology1.86859798
13MP0005248_abnormal_Harderian_gland1.84678364
14MP0002697_abnormal_eye_size1.84610177
15MP0001286_abnormal_eye_development1.84464980
16MP0003077_abnormal_cell_cycle1.82365388
17MP0004957_abnormal_blastocyst_morpholog1.80837089
18MP0003121_genomic_imprinting1.75110429
19MP0008058_abnormal_DNA_repair1.72630454
20MP0008057_abnormal_DNA_replication1.71567925
21MP0003718_maternal_effect1.67961608
22MP0003941_abnormal_skin_development1.67873895
23MP0003861_abnormal_nervous_system1.66517241
24MP0002085_abnormal_embryonic_tissue1.62131411
25MP0009053_abnormal_anal_canal1.61900775
26MP0008932_abnormal_embryonic_tissue1.59706418
27MP0003111_abnormal_nucleus_morphology1.59493950
28MP0001299_abnormal_eye_distance/1.52461244
29MP0004133_heterotaxia1.51531703
30MP0002092_abnormal_eye_morphology1.50188416
31MP0003119_abnormal_digestive_system1.49877986
32MP0008789_abnormal_olfactory_epithelium1.48707856
33MP0003755_abnormal_palate_morphology1.44695057
34MP0005394_taste/olfaction_phenotype1.43918769
35MP0005499_abnormal_olfactory_system1.43918769
36MP0003942_abnormal_urinary_system1.43898381
37MP0001672_abnormal_embryogenesis/_devel1.40098019
38MP0005380_embryogenesis_phenotype1.40098019
39MP0002234_abnormal_pharynx_morphology1.39717472
40MP0003880_abnormal_central_pattern1.38528185
41MP0000049_abnormal_middle_ear1.38145065
42MP0000428_abnormal_craniofacial_morphol1.36308770
43MP0002653_abnormal_ependyma_morphology1.34735864
44MP0003115_abnormal_respiratory_system1.33868065
45MP0003935_abnormal_craniofacial_develop1.33447628
46MP0003122_maternal_imprinting1.33403689
47MP0010307_abnormal_tumor_latency1.32887873
48MP0001529_abnormal_vocalization1.28783366
49MP0000383_abnormal_hair_follicle1.28743528
50MP0009703_decreased_birth_body1.28472706
51MP0003984_embryonic_growth_retardation1.26474215
52MP0000534_abnormal_ureter_morphology1.26199743
53MP0002210_abnormal_sex_determination1.25909198
54MP0000537_abnormal_urethra_morphology1.25377922
55MP0003385_abnormal_body_wall1.23564907
56MP0001697_abnormal_embryo_size1.22151497
57MP0005623_abnormal_meninges_morphology1.22046465
58MP0002088_abnormal_embryonic_growth/wei1.21079231
59MP0001929_abnormal_gametogenesis1.20591884
60MP0003698_abnormal_male_reproductive1.18615104
61MP0001730_embryonic_growth_arrest1.17208517
62MP0000432_abnormal_head_morphology1.15924200
63MP0002111_abnormal_tail_morphology1.15430787
64MP0003123_paternal_imprinting1.14714709
65MP0010352_gastrointestinal_tract_polyps1.14666585
66MP0004197_abnormal_fetal_growth/weight/1.12669129
67MP0002116_abnormal_craniofacial_bone1.09838503
68MP0002282_abnormal_trachea_morphology1.09291871
69MP0000955_abnormal_spinal_cord1.09134435
70MP0005391_vision/eye_phenotype1.08202728
71MP0002152_abnormal_brain_morphology1.07570879
72MP0005076_abnormal_cell_differentiation1.05269701
73MP0010678_abnormal_skin_adnexa1.04828735
74MP0000579_abnormal_nail_morphology1.04176557
75MP0002081_perinatal_lethality1.04169686
76MP0001984_abnormal_olfaction1.04121419
77MP0002938_white_spotting1.03604012
78MP0000350_abnormal_cell_proliferation1.02658021
79MP0002928_abnormal_bile_duct1.01006794
80MP0001145_abnormal_male_reproductive1.00031699
81MP0002080_prenatal_lethality0.99025590
82MP0000631_abnormal_neuroendocrine_gland0.97570839
83MP0001849_ear_inflammation0.96073987
84MP0001188_hyperpigmentation0.95855196
85MP0002109_abnormal_limb_morphology0.94236363
86MP0002102_abnormal_ear_morphology0.92852699
87MP0000762_abnormal_tongue_morphology0.92812365
88MP0005409_darkened_coat_color0.92297739
89MP0002184_abnormal_innervation0.91917512
90MP0004233_abnormal_muscle_weight0.91409095
91MP0002161_abnormal_fertility/fecundity0.90863164
92MP0003787_abnormal_imprinting0.90702209
93MP0003938_abnormal_ear_development0.90400367
94MP0000653_abnormal_sex_gland0.90137416
95MP0002086_abnormal_extraembryonic_tissu0.87706745
96MP0004272_abnormal_basement_membrane0.86932751
97MP0009697_abnormal_copulation0.85998512
98MP0003943_abnormal_hepatobiliary_system0.85992425
99MP0003315_abnormal_perineum_morphology0.85942449
100MP0004811_abnormal_neuron_physiology0.84086098

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.49094479
2Tubulointerstitial nephritis (HP:0001970)3.38514038
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.32249830
4Chronic hepatic failure (HP:0100626)3.18723852
5Abnormal respiratory motile cilium physiology (HP:0012261)2.85779567
6Abnormal respiratory motile cilium morphology (HP:0005938)2.84839937
7Abnormal respiratory epithelium morphology (HP:0012253)2.84839937
8Abnormal ciliary motility (HP:0012262)2.70642127
9Rhinitis (HP:0012384)2.69690932
10Absent/shortened dynein arms (HP:0200106)2.59471418
11Dynein arm defect of respiratory motile cilia (HP:0012255)2.59471418
12Oligodactyly (hands) (HP:0001180)2.47206901
13Hepatoblastoma (HP:0002884)2.44124200
14Pancreatic fibrosis (HP:0100732)2.38339774
15Abnormal number of incisors (HP:0011064)2.32548576
16Intestinal atresia (HP:0011100)2.30489165
17Occipital encephalocele (HP:0002085)2.22339463
18True hermaphroditism (HP:0010459)2.20253718
19Abnormality of the antihelix (HP:0009738)2.20055734
20Ectopic kidney (HP:0000086)2.18876990
21Papillary thyroid carcinoma (HP:0002895)2.15163001
22Anal stenosis (HP:0002025)2.14513145
23Chromsome breakage (HP:0040012)2.10242697
24Anophthalmia (HP:0000528)2.10221206
25Chronic bronchitis (HP:0004469)2.08369798
26Cortical dysplasia (HP:0002539)2.08350229
27High anterior hairline (HP:0009890)2.06300619
28Postaxial foot polydactyly (HP:0001830)2.04940048
29Cerebellar dysplasia (HP:0007033)2.03363875
30Colon cancer (HP:0003003)2.01238454
31Abnormality of the labia minora (HP:0012880)2.00267752
32Oligodactyly (HP:0012165)1.98864418
33Nephronophthisis (HP:0000090)1.96153800
34Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95607833
35Septo-optic dysplasia (HP:0100842)1.94256354
36Aplasia/Hypoplasia of the sternum (HP:0006714)1.92539574
37Nephroblastoma (Wilms tumor) (HP:0002667)1.90918831
38Preaxial hand polydactyly (HP:0001177)1.86361910
39Truncal obesity (HP:0001956)1.85517471
40Broad finger (HP:0001500)1.85306020
41Midline defect of the nose (HP:0004122)1.84114187
42Cutaneous finger syndactyly (HP:0010554)1.83966998
43Intellectual disability, moderate (HP:0002342)1.83821190
44Obsessive-compulsive behavior (HP:0000722)1.83593500
45Cutaneous syndactyly (HP:0012725)1.83467551
46Facial cleft (HP:0002006)1.83002496
47Preaxial foot polydactyly (HP:0001841)1.82842839
48Aqueductal stenosis (HP:0002410)1.80831038
49Increased nuchal translucency (HP:0010880)1.80187808
50Abnormal lung lobation (HP:0002101)1.79537756
51Embryonal renal neoplasm (HP:0011794)1.79537266
52Diastasis recti (HP:0001540)1.77988653
53Pancreatic cysts (HP:0001737)1.77248062
54Abnormal hair whorl (HP:0010721)1.76425283
55Micropenis (HP:0000054)1.76424185
56Broad phalanges of the hand (HP:0009768)1.75775184
57Broad thumb (HP:0011304)1.75563327
58Abnormality of the renal medulla (HP:0100957)1.75195477
59Renal dysplasia (HP:0000110)1.74657616
60Gastrointestinal atresia (HP:0002589)1.74162946
61Shoulder girdle muscle weakness (HP:0003547)1.74029045
62Esophageal atresia (HP:0002032)1.73529977
63Molar tooth sign on MRI (HP:0002419)1.72467913
64Abnormality of midbrain morphology (HP:0002418)1.72467913
65Renal hypoplasia (HP:0000089)1.70968917
66Aplasia/Hypoplasia of the tongue (HP:0010295)1.68263875
67Postaxial hand polydactyly (HP:0001162)1.68149253
68Omphalocele (HP:0001539)1.67665938
69Medulloblastoma (HP:0002885)1.67626335
70Anencephaly (HP:0002323)1.66878712
71Overlapping toe (HP:0001845)1.65784764
72Abnormality of the incisor (HP:0000676)1.65742243
73Abnormality of dentin (HP:0010299)1.64795608
74Broad phalanx (HP:0006009)1.61958784
75Growth hormone deficiency (HP:0000824)1.61665847
76Vitreoretinal degeneration (HP:0000655)1.60972315
77Optic nerve coloboma (HP:0000588)1.60274636
78Genital tract atresia (HP:0001827)1.59790922
79Vaginal atresia (HP:0000148)1.59053299
80Narrow palate (HP:0000189)1.59018218
81Bifid tongue (HP:0010297)1.58265446
82Highly arched eyebrow (HP:0002553)1.56889113
83Optic nerve hypoplasia (HP:0000609)1.56778822
84Abnormality of chromosome stability (HP:0003220)1.56450566
85Broad long bones (HP:0005622)1.55959806
86Deep palmar crease (HP:0006191)1.55880694
87Poor coordination (HP:0002370)1.55771358
88Sclerocornea (HP:0000647)1.55723572
89Dandy-Walker malformation (HP:0001305)1.55514759
90Bronchiectasis (HP:0002110)1.55205740
91Cystic liver disease (HP:0006706)1.52447798
92Abnormality of the lower motor neuron (HP:0002366)1.52183996
93Duplication of thumb phalanx (HP:0009942)1.51796410
94Broad palm (HP:0001169)1.51730126
95Narrow forehead (HP:0000341)1.50489342
96Absent radius (HP:0003974)1.50348804
97Hypoplastic pelvis (HP:0008839)1.50177710
98Intestinal fistula (HP:0100819)1.49701960
99Trigonocephaly (HP:0000243)1.49178716
100Hypoplastic female external genitalia (HP:0012815)1.49122445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.22697259
2CDK123.06532961
3BRD42.90586912
4PLK42.84837113
5CDC72.79557718
6CAMK1G2.65410184
7SRPK12.37914408
8MKNK22.34241202
9MKNK12.23312319
10STK38L2.08527613
11TNIK1.95603196
12TTK1.89805455
13MAP3K101.88268220
14CAMK1D1.83486442
15EPHB21.82583057
16WEE11.81787792
17MAPK151.81717130
18CASK1.76497399
19MAP3K41.66652641
20TSSK61.62609383
21PBK1.61828597
22PLK21.51485656
23LATS11.50589889
24WNK31.42352270
25BCR1.42068450
26FGFR21.39678088
27MARK11.35948978
28PLK31.31135750
29AKT31.27239792
30CDK71.24464648
31PRKD31.23841418
32MET1.16766711
33PASK1.16382860
34TAF11.15621685
35PLK11.12307081
36STK241.11556270
37CDK191.07050910
38WNK11.06889410
39DYRK31.05900393
40NTRK31.05520048
41CHEK21.03410316
42EPHA41.02886371
43DYRK20.99352360
44CHEK10.98958159
45KSR10.96204571
46BRSK20.91563951
47DYRK1B0.91164193
48CDK30.90154198
49PDGFRA0.89367233
50LATS20.88338092
51FGFR10.86781608
52MAP2K40.83963110
53NEK60.80525904
54ATM0.78658407
55CSNK1G20.78514745
56ATR0.77297006
57AURKB0.74799023
58STK390.74326116
59CSNK1G10.73909110
60TRIM280.73771021
61ERBB40.73608703
62MAP2K70.72831249
63NEK20.72102248
64MAP3K90.71088134
65CDK10.70027903
66STK380.69587110
67CDK20.68885884
68DMPK0.68706401
69CDK90.67589631
70MTOR0.66594218
71NTRK10.66576350
72YES10.66508521
73STK30.65362172
74BUB10.63924176
75MELK0.63808328
76NEK10.61051668
77CSNK1E0.60020910
78NEK90.57593515
79DYRK1A0.56908749
80MAP3K120.55924375
81CSNK1A1L0.53808654
82EIF2AK20.53658468
83SGK20.51740087
84CCNB10.49255224
85TGFBR10.48278895
86BRAF0.46619903
87PTK20.46438580
88PRKDC0.45676705
89MST1R0.45266878
90CSNK1G30.44459694
91TYRO30.44193895
92AURKA0.43319073
93GSK3B0.43071306
94BMPR1B0.42383403
95BRSK10.41982011
96MAPK140.41709484
97MAP4K20.41705798
98STK160.40643101
99SGK4940.40588287
100SGK2230.40588287

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.59882911
2Non-homologous end-joining_Homo sapiens_hsa034502.52493217
3Mismatch repair_Homo sapiens_hsa034302.48904652
4RNA transport_Homo sapiens_hsa030132.44663203
5Basal cell carcinoma_Homo sapiens_hsa052172.29765817
6Hedgehog signaling pathway_Homo sapiens_hsa043402.27896219
7Fanconi anemia pathway_Homo sapiens_hsa034602.23854534
8Adherens junction_Homo sapiens_hsa045202.20252648
9mRNA surveillance pathway_Homo sapiens_hsa030152.19089192
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09057418
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07769332
12Hippo signaling pathway_Homo sapiens_hsa043902.02318397
13DNA replication_Homo sapiens_hsa030302.00022513
14Lysine degradation_Homo sapiens_hsa003101.91299269
15Spliceosome_Homo sapiens_hsa030401.85703194
16Basal transcription factors_Homo sapiens_hsa030221.82153481
17Nucleotide excision repair_Homo sapiens_hsa034201.76096503
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73842402
19Homologous recombination_Homo sapiens_hsa034401.68271721
20Notch signaling pathway_Homo sapiens_hsa043301.67377858
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66218948
22MicroRNAs in cancer_Homo sapiens_hsa052061.60981699
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60700105
24Wnt signaling pathway_Homo sapiens_hsa043101.60651540
25TGF-beta signaling pathway_Homo sapiens_hsa043501.56766459
26RNA degradation_Homo sapiens_hsa030181.55182709
27Axon guidance_Homo sapiens_hsa043601.54335699
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46976176
29Oocyte meiosis_Homo sapiens_hsa041141.46207291
30Tight junction_Homo sapiens_hsa045301.34457706
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33118963
32Endometrial cancer_Homo sapiens_hsa052131.26924347
33Colorectal cancer_Homo sapiens_hsa052101.24615880
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23213009
35Thyroid cancer_Homo sapiens_hsa052161.20996006
36Protein export_Homo sapiens_hsa030601.18292297
37p53 signaling pathway_Homo sapiens_hsa041151.17525229
38Base excision repair_Homo sapiens_hsa034101.17390974
39Steroid biosynthesis_Homo sapiens_hsa001001.14844953
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08646427
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04057665
42Prostate cancer_Homo sapiens_hsa052151.04044140
43ECM-receptor interaction_Homo sapiens_hsa045121.03491624
44Small cell lung cancer_Homo sapiens_hsa052221.00761314
45Fatty acid biosynthesis_Homo sapiens_hsa000610.98781292
46Dorso-ventral axis formation_Homo sapiens_hsa043200.95610231
47ErbB signaling pathway_Homo sapiens_hsa040120.91195214
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.89128144
49RNA polymerase_Homo sapiens_hsa030200.88000025
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87160087
51Melanoma_Homo sapiens_hsa052180.83885087
52Chronic myeloid leukemia_Homo sapiens_hsa052200.83379446
53Renal cell carcinoma_Homo sapiens_hsa052110.83015012
54Pathways in cancer_Homo sapiens_hsa052000.82866449
55Proteoglycans in cancer_Homo sapiens_hsa052050.81397710
56Nicotine addiction_Homo sapiens_hsa050330.80254440
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74063886
58Inositol phosphate metabolism_Homo sapiens_hsa005620.73615244
59Glioma_Homo sapiens_hsa052140.72888802
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72643277
61Gap junction_Homo sapiens_hsa045400.71926898
62Focal adhesion_Homo sapiens_hsa045100.70893415
63Melanogenesis_Homo sapiens_hsa049160.70015920
64Taste transduction_Homo sapiens_hsa047420.65115064
65Pancreatic cancer_Homo sapiens_hsa052120.64298764
66Non-small cell lung cancer_Homo sapiens_hsa052230.63707518
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60575438
68FoxO signaling pathway_Homo sapiens_hsa040680.58241761
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58186174
70Rap1 signaling pathway_Homo sapiens_hsa040150.57824217
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54884878
72Long-term depression_Homo sapiens_hsa047300.54562780
73Selenocompound metabolism_Homo sapiens_hsa004500.53485459
74Choline metabolism in cancer_Homo sapiens_hsa052310.51741298
75Pyrimidine metabolism_Homo sapiens_hsa002400.51012993
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50874532
77Bladder cancer_Homo sapiens_hsa052190.48843521
78Vitamin B6 metabolism_Homo sapiens_hsa007500.48137996
79Glutamatergic synapse_Homo sapiens_hsa047240.46760246
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.45788438
81Ribosome_Homo sapiens_hsa030100.45657848
82mTOR signaling pathway_Homo sapiens_hsa041500.44472410
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40395578
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40031497
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.38982454
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38885196
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38876128
88Long-term potentiation_Homo sapiens_hsa047200.37259597
89Purine metabolism_Homo sapiens_hsa002300.36180756
90Estrogen signaling pathway_Homo sapiens_hsa049150.35890416
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35536457
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33776428
93Dopaminergic synapse_Homo sapiens_hsa047280.32147073
94Viral carcinogenesis_Homo sapiens_hsa052030.31364459
95AMPK signaling pathway_Homo sapiens_hsa041520.31063206
96MAPK signaling pathway_Homo sapiens_hsa040100.30810766
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30709990
98Circadian rhythm_Homo sapiens_hsa047100.29326196
99Propanoate metabolism_Homo sapiens_hsa006400.27915444
100Cocaine addiction_Homo sapiens_hsa050300.27273578

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