ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium or flagellum-dependent cell motility (GO:0001539)	9.33836846
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.15526068
3	cilium movement (GO:0003341)	6.74961278
4	axoneme assembly (GO:0035082)	6.57880437
5	retinal cone cell development (GO:0046549)	6.35233646
6	epithelial cilium movement (GO:0003351)	6.01212140
7	axonemal dynein complex assembly (GO:0070286)	5.61615332
8	retinal rod cell development (GO:0046548)	5.41681747
9	protein K11-linked deubiquitination (GO:0035871)	4.95917865
10	motile cilium assembly (GO:0044458)	4.73082984
11	neural tube formation (GO:0001841)	4.51021853
12	photoreceptor cell maintenance (GO:0045494)	4.48780284
13	regulation of cilium movement (GO:0003352)	4.39397738
14	establishment of protein localization to Golgi (GO:0072600)	4.32953497
15	indolalkylamine metabolic process (GO:0006586)	3.90828269
16	tryptophan catabolic process (GO:0006569)	3.86675651
17	indole-containing compound catabolic process (GO:0042436)	3.86675651
18	indolalkylamine catabolic process (GO:0046218)	3.86675651
19	ventricular system development (GO:0021591)	3.76675752
20	cilium organization (GO:0044782)	3.69072108
21	protein targeting to Golgi (GO:0000042)	3.67817267
22	response to pheromone (GO:0019236)	3.62900190
23	tryptophan metabolic process (GO:0006568)	3.59384490
24	cilium assembly (GO:0042384)	3.41824617
25	fucose catabolic process (GO:0019317)	3.39870156
26	L-fucose metabolic process (GO:0042354)	3.39870156
27	L-fucose catabolic process (GO:0042355)	3.39870156
28	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.35200656
29	detection of light stimulus involved in visual perception (GO:0050908)	3.32379405
30	detection of light stimulus involved in sensory perception (GO:0050962)	3.32379405
31	cilium morphogenesis (GO:0060271)	3.30895183
32	protein polyglutamylation (GO:0018095)	3.23456318
33	photoreceptor cell development (GO:0042461)	3.20430147
34	prenylation (GO:0097354)	3.13572375
35	protein prenylation (GO:0018342)	3.13572375
36	eye photoreceptor cell development (GO:0042462)	3.13417773
37	interkinetic nuclear migration (GO:0022027)	3.09004640
38	microtubule bundle formation (GO:0001578)	3.05214001
39	adaptation of signaling pathway (GO:0023058)	3.04175479
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.04148201
41	regulation of B cell receptor signaling pathway (GO:0050855)	3.02360618
42	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.00775930
43	regulation of translation, ncRNA-mediated (GO:0045974)	3.00775930
44	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.00775930
45	snRNA transcription (GO:0009301)	2.97560445
46	cellular component assembly involved in morphogenesis (GO:0010927)	2.95304025
47	left/right axis specification (GO:0070986)	2.93483615
48	negative regulation of mast cell activation (GO:0033004)	2.91022957
49	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.89821216
50	cAMP catabolic process (GO:0006198)	2.88511006
51	protein localization to Golgi apparatus (GO:0034067)	2.87791223
52	kynurenine metabolic process (GO:0070189)	2.85970336
53	negative regulation of complement activation (GO:0045916)	2.84643075
54	intraciliary transport (GO:0042073)	2.84198203
55	dopamine transport (GO:0015872)	2.82226149
56	monoubiquitinated protein deubiquitination (GO:0035520)	2.78899019
57	brain morphogenesis (GO:0048854)	2.77913112
58	rRNA catabolic process (GO:0016075)	2.77748934
59	cell wall macromolecule catabolic process (GO:0016998)	2.72973405
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72134565
61	nonmotile primary cilium assembly (GO:0035058)	2.72022615
62	piRNA metabolic process (GO:0034587)	2.71804454
63	cyclic nucleotide catabolic process (GO:0009214)	2.71613330
64	sperm motility (GO:0030317)	2.70914504
65	indole-containing compound metabolic process (GO:0042430)	2.68653576
66	histone mRNA catabolic process (GO:0071044)	2.66949143
67	centriole replication (GO:0007099)	2.64750807
68	reflex (GO:0060004)	2.63737299
69	interleukin-6-mediated signaling pathway (GO:0070102)	2.61301389
70	protein localization to cilium (GO:0061512)	2.61262073
71	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.59550813
72	oxidative demethylation (GO:0070989)	2.57797817
73	protein K48-linked deubiquitination (GO:0071108)	2.56942052
74	microtubule anchoring (GO:0034453)	2.52506750
75	synapsis (GO:0007129)	2.48632974
76	negative regulation of protein activation cascade (GO:2000258)	2.45231029
77	DNA methylation involved in gamete generation (GO:0043046)	2.44753575
78	protein K63-linked deubiquitination (GO:0070536)	2.44335599
79	thyroid hormone metabolic process (GO:0042403)	2.44135006
80	tachykinin receptor signaling pathway (GO:0007217)	2.41608110
81	ubiquinone biosynthetic process (GO:0006744)	2.40208169
82	cell wall macromolecule metabolic process (GO:0044036)	2.39992359
83	interferon-gamma production (GO:0032609)	2.39700821
84	signal peptide processing (GO:0006465)	2.37373014
85	sulfation (GO:0051923)	2.37018641
86	regulation of MHC class II biosynthetic process (GO:0045346)	2.36715677
87	multicellular organism reproduction (GO:0032504)	2.36434423
88	phosphorelay signal transduction system (GO:0000160)	2.35982143
89	NAD biosynthetic process (GO:0009435)	2.34454076
90	benzene-containing compound metabolic process (GO:0042537)	2.33868434
91	tyrosine phosphorylation of STAT protein (GO:0007260)	2.32023530
92	double-strand break repair via homologous recombination (GO:0000724)	2.29360750
93	cell projection assembly (GO:0030031)	2.29317584
94	acrosome reaction (GO:0007340)	2.28858887
95	recombinational repair (GO:0000725)	2.28428937
96	hepatocyte apoptotic process (GO:0097284)	2.27332719
97	negative regulation of humoral immune response (GO:0002921)	2.27273870
98	embryonic epithelial tube formation (GO:0001838)	2.25876374
99	phospholipid translocation (GO:0045332)	2.25841621
100	lipid translocation (GO:0034204)	2.25841621

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.41987261
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.11445696
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.80448897
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.73912686
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.70348650
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58600362
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.55906884
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54317767
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.53693582
10	VDR_22108803_ChIP-Seq_LS180_Human	2.53102889
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.45225550
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.33874206
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30032776
14	FUS_26573619_Chip-Seq_HEK293_Human	2.23735618
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.22783308
16	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.14090924
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.11294519
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07374181
19	P300_19829295_ChIP-Seq_ESCs_Human	2.00813965
20	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.99796643
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98404652
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.97112578
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.96307453
24	STAT3_23295773_ChIP-Seq_U87_Human	1.89202004
25	EWS_26573619_Chip-Seq_HEK293_Human	1.86562787
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.85256502
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.84104803
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.81486615
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.77289850
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.69052477
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.69052477
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68935652
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.66973298
34	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.66668166
35	TCF4_23295773_ChIP-Seq_U87_Human	1.63823772
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.60269186
37	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.59080861
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54392050
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.53140093
40	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48141117
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45285101
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45122055
43	AR_25329375_ChIP-Seq_VCAP_Human	1.44395574
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43327133
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42700709
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41091959
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40831143
48	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.40432490
49	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.39595015
50	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.38669759
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.38187148
52	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.38079553
53	TP53_16413492_ChIP-PET_HCT116_Human	1.36981154
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.33926509
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32688172
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32688172
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.31572039
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.30238066
59	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.29950106
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.29418414
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29061558
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.28913669
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28181974
64	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26308710
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25398922
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24163548
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24163548
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.23924055
69	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.23124757
70	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.23080622
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22895672
72	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.21820045
73	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21298520
74	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20511168
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19188536
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.18393058
77	AHR_22903824_ChIP-Seq_MCF-7_Human	1.18027080
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15718703
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14437348
80	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.13778250
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13593043
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13555116
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13550739
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.12239025
85	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.11846791
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11243070
87	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10860923
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07858942
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.07547061
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.06200074
91	P300_18555785_Chip-Seq_ESCs_Mouse	1.05942307
92	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05610707
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05380191
94	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05207093
95	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03846591
96	KDM2B_26808549_Chip-Seq_REH_Human	1.03608412
97	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03329636
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01227655
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98887951
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98887951

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.25118065
2	MP0008057_abnormal_DNA_replication	3.66307136
3	MP0003195_calcinosis	3.53032183
4	MP0008877_abnormal_DNA_methylation	3.48240458
5	MP0005551_abnormal_eye_electrophysiolog	2.90329019
6	MP0005253_abnormal_eye_physiology	2.70493970
7	MP0000427_abnormal_hair_cycle	2.20796155
8	MP0000383_abnormal_hair_follicle	2.19022267
9	MP0001984_abnormal_olfaction	2.08288203
10	MP0009046_muscle_twitch	2.07156099
11	MP0006072_abnormal_retinal_apoptosis	1.89128657
12	MP0003880_abnormal_central_pattern	1.85414537
13	MP0003646_muscle_fatigue	1.77006827
14	MP0002653_abnormal_ependyma_morphology	1.67926706
15	MP0003787_abnormal_imprinting	1.67275689
16	MP0005310_abnormal_salivary_gland	1.64247315
17	MP0003724_increased_susceptibility_to	1.61478174
18	MP0006276_abnormal_autonomic_nervous	1.60537891
19	MP0010678_abnormal_skin_adnexa	1.57568471
20	MP0006054_spinal_hemorrhage	1.56352249
21	MP0004142_abnormal_muscle_tone	1.54245748
22	MP0001486_abnormal_startle_reflex	1.54160265
23	MP0004043_abnormal_pH_regulation	1.53573985
24	MP0001968_abnormal_touch/_nociception	1.52392750
25	MP0001501_abnormal_sleep_pattern	1.51868034
26	MP0003045_fibrosis	1.45382040
27	MP0002102_abnormal_ear_morphology	1.41249957
28	MP0003183_abnormal_peptide_metabolism	1.37437827
29	MP0005174_abnormal_tail_pigmentation	1.37417907
30	MP0000015_abnormal_ear_pigmentation	1.34873573
31	MP0002876_abnormal_thyroid_physiology	1.31772879
32	MP0005410_abnormal_fertilization	1.30746627
33	MP0002736_abnormal_nociception_after	1.27829976
34	MP0010386_abnormal_urinary_bladder	1.27132882
35	MP0004484_altered_response_of	1.22106574
36	MP0002168_other_aberrant_phenotype	1.19878898
37	MP0009745_abnormal_behavioral_response	1.19471785
38	MP0003950_abnormal_plasma_membrane	1.18975727
39	MP0005645_abnormal_hypothalamus_physiol	1.17644567
40	MP0000372_irregular_coat_pigmentation	1.15452967
41	MP0005389_reproductive_system_phenotype	1.13961840
42	MP0001929_abnormal_gametogenesis	1.13212690
43	MP0002229_neurodegeneration	1.11934752
44	MP0003698_abnormal_male_reproductive	1.11346386
45	MP0008995_early_reproductive_senescence	1.09855554
46	MP0002160_abnormal_reproductive_system	1.09751376
47	MP0008872_abnormal_physiological_respon	1.09014073
48	MP0002009_preneoplasia	1.08025007
49	MP0002272_abnormal_nervous_system	1.05443958
50	MP0000631_abnormal_neuroendocrine_gland	1.05232722
51	MP0003656_abnormal_erythrocyte_physiolo	1.05184929
52	MP0005167_abnormal_blood-brain_barrier	1.04135454
53	MP0008875_abnormal_xenobiotic_pharmacok	1.01376456
54	MP0000647_abnormal_sebaceous_gland	1.00539917
55	MP0001324_abnormal_eye_pigmentation	0.99517743
56	MP0001970_abnormal_pain_threshold	0.96501728
57	MP0005395_other_phenotype	0.96315489
58	MP0004134_abnormal_chest_morphology	0.96196671
59	MP0009697_abnormal_copulation	0.94821788
60	MP0005195_abnormal_posterior_eye	0.94257006
61	MP0004215_abnormal_myocardial_fiber	0.93956128
62	MP0004924_abnormal_behavior	0.93172347
63	MP0005386_behavior/neurological_phenoty	0.93172347
64	MP0003718_maternal_effect	0.91574677
65	MP0001986_abnormal_taste_sensitivity	0.91346722
66	MP0002572_abnormal_emotion/affect_behav	0.88127967
67	MP0000230_abnormal_systemic_arterial	0.86742112
68	MP0002067_abnormal_sensory_capabilities	0.86367702
69	MP0005379_endocrine/exocrine_gland_phen	0.86249899
70	MP0002735_abnormal_chemical_nociception	0.85684953
71	MP0006082_CNS_inflammation	0.84751080
72	MP0002928_abnormal_bile_duct	0.84111041
73	MP0005075_abnormal_melanosome_morpholog	0.83140950
74	MP0005391_vision/eye_phenotype	0.83004573
75	MP0002163_abnormal_gland_morphology	0.82563124
76	MP0002277_abnormal_respiratory_mucosa	0.81880198
77	MP0002909_abnormal_adrenal_gland	0.81833533
78	MP0003633_abnormal_nervous_system	0.81107583
79	MP0001800_abnormal_humoral_immune	0.80354238
80	MP0003878_abnormal_ear_physiology	0.79888471
81	MP0005377_hearing/vestibular/ear_phenot	0.79888471
82	MP0003011_delayed_dark_adaptation	0.79840962
83	MP0001485_abnormal_pinna_reflex	0.77678886
84	MP0002557_abnormal_social/conspecific_i	0.76944709
85	MP0004145_abnormal_muscle_electrophysio	0.76544945
86	MP0000653_abnormal_sex_gland	0.76235702
87	MP0005266_abnormal_metabolism	0.74746893
88	MP0002166_altered_tumor_susceptibility	0.71817717
89	MP0003252_abnormal_bile_duct	0.71071383
90	MP0004381_abnormal_hair_follicle	0.70542979
91	MP0004147_increased_porphyrin_level	0.70367292
92	MP0005085_abnormal_gallbladder_physiolo	0.70053342
93	MP0002095_abnormal_skin_pigmentation	0.68567664
94	MP0005671_abnormal_response_to	0.67826720
95	MP0000465_gastrointestinal_hemorrhage	0.67241696
96	MP0001835_abnormal_antigen_presentation	0.66987563
97	MP0002210_abnormal_sex_determination	0.66931600
98	MP0003763_abnormal_thymus_physiology	0.66511914
99	MP0010329_abnormal_lipoprotein_level	0.65450555
100	MP0001919_abnormal_reproductive_system	0.64937977

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.23858939
2	Absent/shortened dynein arms (HP:0200106)	7.23858939
3	Abnormal ciliary motility (HP:0012262)	5.48549351
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.29537727
5	Chronic hepatic failure (HP:0100626)	5.10647501
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.95827180
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.84833561
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.73535656
9	Abnormal respiratory epithelium morphology (HP:0012253)	4.73535656
10	Tubulointerstitial nephritis (HP:0001970)	3.97500575
11	Abnormal rod and cone electroretinograms (HP:0008323)	3.96107669
12	Pancreatic cysts (HP:0001737)	3.87013332
13	Pancreatic fibrosis (HP:0100732)	3.71612759
14	True hermaphroditism (HP:0010459)	3.68581579
15	Molar tooth sign on MRI (HP:0002419)	3.67331528
16	Abnormality of midbrain morphology (HP:0002418)	3.67331528
17	Rhinitis (HP:0012384)	3.55705582
18	Nephronophthisis (HP:0000090)	3.50992600
19	Bony spicule pigmentary retinopathy (HP:0007737)	3.34848905
20	Medial flaring of the eyebrow (HP:0010747)	3.21657452
21	Chronic bronchitis (HP:0004469)	3.11596258
22	Abnormality of the renal medulla (HP:0100957)	3.10232629
23	Bronchiectasis (HP:0002110)	3.09773579
24	Constricted visual fields (HP:0001133)	2.95196897
25	Cerebellar dysplasia (HP:0007033)	2.94215701
26	Gaze-evoked nystagmus (HP:0000640)	2.90995075
27	Abnormality of the renal cortex (HP:0011035)	2.84808378
28	Attenuation of retinal blood vessels (HP:0007843)	2.77038861
29	Congenital primary aphakia (HP:0007707)	2.74340859
30	Gait imbalance (HP:0002141)	2.67615457
31	Type II lissencephaly (HP:0007260)	2.53534403
32	Nephrogenic diabetes insipidus (HP:0009806)	2.45084204
33	Bronchitis (HP:0012387)	2.42048912
34	Tubular atrophy (HP:0000092)	2.39059263
35	Occipital encephalocele (HP:0002085)	2.37057988
36	Genetic anticipation (HP:0003743)	2.33467629
37	Cystic liver disease (HP:0006706)	2.32022898
38	Hyperventilation (HP:0002883)	2.30933055
39	Abnormal drinking behavior (HP:0030082)	2.30037210
40	Polydipsia (HP:0001959)	2.30037210
41	Febrile seizures (HP:0002373)	2.27767917
42	Poor coordination (HP:0002370)	2.24723213
43	Genital tract atresia (HP:0001827)	2.20827739
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.18436930
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14879818
46	Congenital stationary night blindness (HP:0007642)	2.14588726
47	Cone-rod dystrophy (HP:0000548)	2.14457494
48	Decreased circulating renin level (HP:0003351)	2.11870883
49	Progressive cerebellar ataxia (HP:0002073)	2.10227461
50	Tubulointerstitial abnormality (HP:0001969)	2.08190155
51	Vaginal atresia (HP:0000148)	2.07583058
52	Absent speech (HP:0001344)	2.04376315
53	Congenital hepatic fibrosis (HP:0002612)	2.03843216
54	Abolished electroretinogram (ERG) (HP:0000550)	2.02899064
55	Stomatitis (HP:0010280)	1.99200201
56	Recurrent sinusitis (HP:0011108)	1.98395287
57	Decreased central vision (HP:0007663)	1.97325312
58	Renal cortical cysts (HP:0000803)	1.96096711
59	Postaxial foot polydactyly (HP:0001830)	1.94754076
60	Stomach cancer (HP:0012126)	1.94659255
61	Recurrent bronchitis (HP:0002837)	1.94235113
62	Male pseudohermaphroditism (HP:0000037)	1.90555029
63	Fair hair (HP:0002286)	1.90075716
64	Abnormality of macular pigmentation (HP:0008002)	1.87876842
65	Lissencephaly (HP:0001339)	1.86720864
66	Partial agenesis of the corpus callosum (HP:0001338)	1.85792359
67	Widely spaced teeth (HP:0000687)	1.84591290
68	Progressive inability to walk (HP:0002505)	1.84234886
69	Hypothermia (HP:0002045)	1.83312306
70	Anencephaly (HP:0002323)	1.80067399
71	Retinitis pigmentosa (HP:0000510)	1.78883562
72	Furrowed tongue (HP:0000221)	1.78073116
73	Metaphyseal dysplasia (HP:0100255)	1.77858348
74	Protruding tongue (HP:0010808)	1.76306267
75	Menstrual irregularities (HP:0000858)	1.75470852
76	Inability to walk (HP:0002540)	1.74698233
77	Bile duct proliferation (HP:0001408)	1.73753674
78	Abnormal biliary tract physiology (HP:0012439)	1.73753674
79	Postaxial hand polydactyly (HP:0001162)	1.73337361
80	Astigmatism (HP:0000483)	1.71859575
81	Portal hypertension (HP:0001409)	1.71306752
82	Thyroiditis (HP:0100646)	1.69634359
83	Large for gestational age (HP:0001520)	1.67521488
84	Hyperkalemia (HP:0002153)	1.66363899
85	Nasal polyposis (HP:0100582)	1.62985636
86	Polyuria (HP:0000103)	1.62684129
87	Prominent nasal bridge (HP:0000426)	1.61429536
88	Facial diplegia (HP:0001349)	1.60907799
89	Hypokalemic alkalosis (HP:0001949)	1.58415064
90	Chronic sinusitis (HP:0011109)	1.58367915
91	Congenital sensorineural hearing impairment (HP:0008527)	1.56861758
92	Oculomotor apraxia (HP:0000657)	1.55947003
93	Macular degeneration (HP:0000608)	1.55611497
94	Growth hormone deficiency (HP:0000824)	1.55443979
95	Short foot (HP:0001773)	1.53559219
96	Photophobia (HP:0000613)	1.53339590
97	Generalized hypopigmentation of hair (HP:0011358)	1.52742565
98	Truncal obesity (HP:0001956)	1.50229040
99	Abnormality of the hepatic vasculature (HP:0006707)	1.48700661
100	Hip dysplasia (HP:0001385)	1.46852119

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.53853532
2	MAP4K2	2.83492856
3	WNK3	2.45021162
4	TAOK3	2.31819417
5	MST4	2.21233624
6	ACVR1B	2.03509527
7	BMPR1B	2.01361577
8	STK38L	1.87861688
9	IRAK1	1.84424240
10	NUAK1	1.81969985
11	ADRBK2	1.78784903
12	OXSR1	1.69639752
13	MAP3K4	1.62559429
14	STK39	1.62404132
15	TEC	1.59497061
16	AKT3	1.58279404
17	PINK1	1.56583724
18	PIK3CG	1.55098509
19	INSRR	1.49317210
20	PAK3	1.45004118
21	MAPK13	1.44811013
22	ZAK	1.40662621
23	FER	1.35755223
24	TXK	1.35415396
25	GRK1	1.32744616
26	WNK4	1.30012489
27	BRSK2	1.20895182
28	PDK2	1.18245911
29	CAMKK2	1.18106422
30	PTK2B	1.08828270
31	ERBB3	1.08364964
32	SGK2	1.07888120
33	TRIM28	1.07438707
34	BLK	1.01295077
35	PLK2	0.98949949
36	BCR	0.93789276
37	BRD4	0.86319409
38	TNK2	0.84415031
39	PRKCE	0.84166113
40	CASK	0.80710838
41	ADRBK1	0.80390524
42	ITK	0.80120565
43	MAP2K7	0.79689042
44	LATS1	0.79562981
45	WNK1	0.78830005
46	TNIK	0.71120571
47	STK3	0.70938112
48	NLK	0.69576311
49	EIF2AK3	0.68777662
50	EPHA3	0.66075138
51	TYK2	0.65567867
52	PIK3CA	0.65483309
53	STK38	0.64404590
54	FGFR2	0.64384477
55	BTK	0.63849924
56	STK11	0.62620873
57	CSNK1A1L	0.62346560
58	MAPK15	0.59524303
59	YES1	0.58750445
60	IKBKB	0.56970855
61	TRPM7	0.56920998
62	MAP2K4	0.56740946
63	PLK4	0.56672795
64	ERBB2	0.56226815
65	NTRK3	0.55811684
66	IKBKE	0.55284562
67	MAP3K2	0.55225036
68	MAP3K7	0.54655458
69	NEK6	0.52572692
70	MUSK	0.51310832
71	MKNK2	0.50712199
72	CAMK2A	0.50400264
73	CSNK1G1	0.49182907
74	GRK5	0.48883394
75	DAPK2	0.48801881
76	PRKAA2	0.47899760
77	GRK7	0.46994928
78	JAK1	0.46916829
79	PRKCQ	0.45831295
80	SGK223	0.45494961
81	SGK494	0.45494961
82	KIT	0.44861204
83	SRPK1	0.44706471
84	HCK	0.43177045
85	CSNK1G2	0.41703769
86	RPS6KA5	0.41672498
87	CAMK1G	0.39842404
88	TGFBR1	0.39280342
89	FES	0.37817714
90	ATM	0.37794244
91	IRAK4	0.37757025
92	LYN	0.37516191
93	PRKG1	0.37408552
94	ABL1	0.36696856
95	SGK3	0.35919528
96	MKNK1	0.35723418
97	CAMK4	0.35683307
98	BMPR2	0.35264781
99	PRKAA1	0.35082886
100	SYK	0.34805497

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.76601288
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.58056007
3	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.17103380
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.16248013
5	Nicotine addiction_Homo sapiens_hsa05033	2.15988567
6	ABC transporters_Homo sapiens_hsa02010	2.11391449
7	Butanoate metabolism_Homo sapiens_hsa00650	2.09120013
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.06954153
9	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.06559510
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03723077
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99394645
12	Selenocompound metabolism_Homo sapiens_hsa00450	1.86169556
13	Phototransduction_Homo sapiens_hsa04744	1.85219612
14	Basal transcription factors_Homo sapiens_hsa03022	1.84943200
15	Circadian rhythm_Homo sapiens_hsa04710	1.75534139
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.73734041
17	Taste transduction_Homo sapiens_hsa04742	1.72319714
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.70378581
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.69194864
20	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.68730777
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.55874285
22	Olfactory transduction_Homo sapiens_hsa04740	1.53784587
23	Morphine addiction_Homo sapiens_hsa05032	1.52735999
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.42025663
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.39637943
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.39174211
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.32945409
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.31015385
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.29430574
30	Regulation of autophagy_Homo sapiens_hsa04140	1.28261335
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26034070
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.25808992
33	Propanoate metabolism_Homo sapiens_hsa00640	1.24578531
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.23818208
35	Homologous recombination_Homo sapiens_hsa03440	1.23583876
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18791614
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.15867361
38	Salivary secretion_Homo sapiens_hsa04970	1.11850447
39	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09910328
40	Retinol metabolism_Homo sapiens_hsa00830	1.08589300
41	GABAergic synapse_Homo sapiens_hsa04727	1.07845890
42	Serotonergic synapse_Homo sapiens_hsa04726	1.07213056
43	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.06090479
44	Glutamatergic synapse_Homo sapiens_hsa04724	1.03002276
45	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.00015632
46	Peroxisome_Homo sapiens_hsa04146	0.97496272
47	Calcium signaling pathway_Homo sapiens_hsa04020	0.97412852
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.97387585
49	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.97119795
50	Circadian entrainment_Homo sapiens_hsa04713	0.96782291
51	One carbon pool by folate_Homo sapiens_hsa00670	0.94574720
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.93301704
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92949752
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89586196
55	Histidine metabolism_Homo sapiens_hsa00340	0.84675442
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.84472441
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.80900151
58	Lysine degradation_Homo sapiens_hsa00310	0.80582325
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.80489207
60	Caffeine metabolism_Homo sapiens_hsa00232	0.74134598
61	cAMP signaling pathway_Homo sapiens_hsa04024	0.73776771
62	RNA degradation_Homo sapiens_hsa03018	0.72610290
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71120605
64	Platelet activation_Homo sapiens_hsa04611	0.70881391
65	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.70361881
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68922943
67	Long-term depression_Homo sapiens_hsa04730	0.68516653
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.63519205
69	Huntingtons disease_Homo sapiens_hsa05016	0.60186801
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.59915956
71	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58226757
72	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.55477236
73	Renin secretion_Homo sapiens_hsa04924	0.54943418
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50784999
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50772018
76	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50561077
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50041219
78	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48223916
79	Insulin secretion_Homo sapiens_hsa04911	0.47867904
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47366915
81	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47312371
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46879894
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.45621274
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.45365607
85	Measles_Homo sapiens_hsa05162	0.44715584
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44691574
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43620668
88	Amphetamine addiction_Homo sapiens_hsa05031	0.42674220
89	Protein export_Homo sapiens_hsa03060	0.41470624
90	Purine metabolism_Homo sapiens_hsa00230	0.38833064
91	Fatty acid degradation_Homo sapiens_hsa00071	0.38761621
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.37481436
93	Cholinergic synapse_Homo sapiens_hsa04725	0.35893279
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35657533
95	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.34193171
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.33523871
97	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.32956273
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31362375
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.31306667
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.31115632

KIAA0825

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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