ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	4.31422719
2	epithelial cilium movement (GO:0003351)	3.71516150
3	pyrimidine nucleobase catabolic process (GO:0006208)	3.71226205
4	cilium movement (GO:0003341)	3.55480978
5	DNA methylation involved in gamete generation (GO:0043046)	3.49510195
6	nucleobase catabolic process (GO:0046113)	3.40094867
7	axonemal dynein complex assembly (GO:0070286)	3.38210064
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.34242442
9	presynaptic membrane assembly (GO:0097105)	3.34210508
10	synapsis (GO:0007129)	3.33921870
11	intraciliary transport (GO:0042073)	3.26776383
12	nonmotile primary cilium assembly (GO:0035058)	3.26044705
13	positive regulation of meiosis (GO:0045836)	3.23538521
14	presynaptic membrane organization (GO:0097090)	3.20610685
15	regulation of cilium movement (GO:0003352)	3.13487909
16	regulation of meiosis I (GO:0060631)	3.11534192
17	positive regulation of meiotic cell cycle (GO:0051446)	3.08608039
18	male meiosis I (GO:0007141)	3.07768752
19	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.07268140
20	male meiosis (GO:0007140)	3.07161946
21	protein localization to cilium (GO:0061512)	3.04791969
22	axoneme assembly (GO:0035082)	3.03955584
23	cilium organization (GO:0044782)	3.03847311
24	cilium assembly (GO:0042384)	3.03531597
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.03143099
26	behavioral response to nicotine (GO:0035095)	3.02364565
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.00874758
28	postsynaptic membrane organization (GO:0001941)	2.99103149
29	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.98972387
30	cornea development in camera-type eye (GO:0061303)	2.85472283
31	auditory behavior (GO:0031223)	2.82683554
32	neuron cell-cell adhesion (GO:0007158)	2.79832929
33	axonal fasciculation (GO:0007413)	2.77134728
34	transmission of nerve impulse (GO:0019226)	2.76294607
35	regulation of microtubule-based movement (GO:0060632)	2.76015546
36	positive regulation of mitochondrial fission (GO:0090141)	2.70351441
37	cilium morphogenesis (GO:0060271)	2.67766115
38	protein polyglutamylation (GO:0018095)	2.65400202
39	retinal ganglion cell axon guidance (GO:0031290)	2.65059836
40	protein localization to synapse (GO:0035418)	2.64924708
41	chromosome organization involved in meiosis (GO:0070192)	2.53942702
42	limb development (GO:0060173)	2.51584647
43	appendage development (GO:0048736)	2.51584647
44	dendritic spine morphogenesis (GO:0060997)	2.50653271
45	smoothened signaling pathway (GO:0007224)	2.49652523
46	acrosome reaction (GO:0007340)	2.45240212
47	left/right pattern formation (GO:0060972)	2.43672668
48	synapse assembly (GO:0007416)	2.41993621
49	gamma-aminobutyric acid transport (GO:0015812)	2.40275635
50	neurofilament cytoskeleton organization (GO:0060052)	2.38609859
51	neurotransmitter-gated ion channel clustering (GO:0072578)	2.38294217
52	mechanosensory behavior (GO:0007638)	2.37042092
53	neuron recognition (GO:0008038)	2.36654356
54	resolution of meiotic recombination intermediates (GO:0000712)	2.35248124
55	cellular component assembly involved in morphogenesis (GO:0010927)	2.34209249
56	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.32910774
57	left/right axis specification (GO:0070986)	2.32865631
58	microtubule bundle formation (GO:0001578)	2.31824168
59	brain morphogenesis (GO:0048854)	2.31101273
60	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.29848227
61	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.29344678
62	primary amino compound metabolic process (GO:1901160)	2.28897654
63	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.27950643
64	response to auditory stimulus (GO:0010996)	2.27397988
65	hindbrain development (GO:0030902)	2.26281526
66	spinal cord motor neuron differentiation (GO:0021522)	2.25812804
67	vocalization behavior (GO:0071625)	2.23781588
68	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.22995043
69	neurotransmitter secretion (GO:0007269)	2.22636156
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.22310885
71	detection of light stimulus involved in visual perception (GO:0050908)	2.22310885
72	dendrite morphogenesis (GO:0048813)	2.21738121
73	detection of calcium ion (GO:0005513)	2.21397124
74	meiosis I (GO:0007127)	2.20274291
75	protein import into peroxisome matrix (GO:0016558)	2.19313149
76	neural tube formation (GO:0001841)	2.19291532
77	central nervous system neuron axonogenesis (GO:0021955)	2.18908429
78	regulation of glucokinase activity (GO:0033131)	2.17796837
79	regulation of hexokinase activity (GO:1903299)	2.17796837
80	serotonin metabolic process (GO:0042428)	2.17632912
81	microtubule depolymerization (GO:0007019)	2.17339154
82	sperm motility (GO:0030317)	2.16855040
83	neuron fate specification (GO:0048665)	2.16417470
84	somite rostral/caudal axis specification (GO:0032525)	2.15796045
85	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.14958249
86	central nervous system projection neuron axonogenesis (GO:0021952)	2.14440262
87	hippocampus development (GO:0021766)	2.14211643
88	motile cilium assembly (GO:0044458)	2.14151138
89	behavioral response to ethanol (GO:0048149)	2.13961393
90	glutamate receptor signaling pathway (GO:0007215)	2.13555773
91	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.12985405
92	negative regulation of axon guidance (GO:1902668)	2.12682318
93	embryonic foregut morphogenesis (GO:0048617)	2.12182960
94	cerebral cortex radially oriented cell migration (GO:0021799)	2.11189710
95	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.11004655
96	neuronal action potential (GO:0019228)	2.10383741
97	establishment of nucleus localization (GO:0040023)	2.09763045
98	photoreceptor cell maintenance (GO:0045494)	2.09395215
99	startle response (GO:0001964)	2.09219733
100	ubiquinone metabolic process (GO:0006743)	2.09171291

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.25560413
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.05806670
3	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76493795
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.75669002
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.71328886
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62194347
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.60453939
8	FUS_26573619_Chip-Seq_HEK293_Human	2.51326019
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.49184124
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37461181
11	VDR_22108803_ChIP-Seq_LS180_Human	2.33929670
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.32292498
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.24211411
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.14269362
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.10673563
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.04552337
17	RNF2_27304074_Chip-Seq_NSC_Mouse	2.04227482
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.93685706
19	* P300_19829295_ChIP-Seq_ESCs_Human	1.90585026
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.90280259
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88076974
22	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.80923405
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77965721
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77516009
25	EWS_26573619_Chip-Seq_HEK293_Human	1.77100780
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71008480
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.70034068
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67506194
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.66241537
30	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.65513811
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.61806140
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.59726701
33	* STAT3_23295773_ChIP-Seq_U87_Human	1.59032186
34	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51715330
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.51242356
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50944884
37	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50712369
38	AR_25329375_ChIP-Seq_VCAP_Human	1.50610143
39	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50514826
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.48452506
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47748769
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.47188384
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45956559
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.42358240
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.40103428
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.40091909
47	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37535633
48	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.37125667
49	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.36511172
50	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.34725380
51	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.34618558
52	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.31881005
53	TCF4_23295773_ChIP-Seq_U87_Human	1.29952837
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27738723
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.27738723
56	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25686831
57	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.25181331
58	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20856952
59	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.19179804
60	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18340929
61	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18070406
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.18062909
63	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17890934
64	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17838669
65	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17470959
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.16601210
67	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16439311
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.16426414
69	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.15954905
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14524451
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14099094
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.14072148
73	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.12950770
74	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.12948634
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.11861597
76	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09273704
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07331014
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.07254354
79	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06063811
80	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06063811
81	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05714397
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05687411
83	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.03895845
84	SOX9_26525672_Chip-Seq_HEART_Mouse	1.03626690
85	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02593639
86	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02452214
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01481002
88	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00977269
89	JUN_21703547_ChIP-Seq_K562_Human	1.00265194
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99674266
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99674266
92	* SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99474481
93	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.99005788
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98823687
95	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.98623406
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97834935
97	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.96487552
98	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.96487552
99	TP53_18474530_ChIP-ChIP_U2OS_Human	0.96305178
100	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.96251575

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.64962110
2	MP0008877_abnormal_DNA_methylation	2.53916779
3	MP0003122_maternal_imprinting	2.29626350
4	MP0006292_abnormal_olfactory_placode	2.06327458
5	MP0009046_muscle_twitch	2.05778278
6	MP0000778_abnormal_nervous_system	2.04474778
7	MP0002638_abnormal_pupillary_reflex	1.98038120
8	MP0000569_abnormal_digit_pigmentation	1.94554134
9	MP0002938_white_spotting	1.93566409
10	MP0001984_abnormal_olfaction	1.90910597
11	MP0005423_abnormal_somatic_nervous	1.86630182
12	MP0006276_abnormal_autonomic_nervous	1.85261652
13	MP0003787_abnormal_imprinting	1.82302896
14	MP0004270_analgesia	1.80482393
15	MP0002909_abnormal_adrenal_gland	1.79353406
16	MP0003890_abnormal_embryonic-extraembry	1.73366083
17	MP0002653_abnormal_ependyma_morphology	1.69822226
18	MP0002837_dystrophic_cardiac_calcinosis	1.69139160
19	MP0009745_abnormal_behavioral_response	1.67341853
20	MP0000566_synostosis	1.66814708
21	MP0004859_abnormal_synaptic_plasticity	1.63798388
22	MP0006072_abnormal_retinal_apoptosis	1.62714207
23	MP0001529_abnormal_vocalization	1.62305363
24	MP0000631_abnormal_neuroendocrine_gland	1.61451527
25	MP0002272_abnormal_nervous_system	1.60992858
26	MP0003635_abnormal_synaptic_transmissio	1.59904222
27	MP0003121_genomic_imprinting	1.58805464
28	MP0005253_abnormal_eye_physiology	1.54055732
29	MP0002572_abnormal_emotion/affect_behav	1.50185520
30	MP0002557_abnormal_social/conspecific_i	1.49188968
31	MP0002064_seizures	1.47160018
32	MP0005551_abnormal_eye_electrophysiolog	1.47065439
33	MP0002184_abnormal_innervation	1.46644960
34	MP0004133_heterotaxia	1.46301013
35	MP0001486_abnormal_startle_reflex	1.43521896
36	MP0002160_abnormal_reproductive_system	1.42366603
37	MP0002234_abnormal_pharynx_morphology	1.42160608
38	MP0002102_abnormal_ear_morphology	1.42042078
39	MP0002734_abnormal_mechanical_nocicepti	1.41127114
40	MP0002063_abnormal_learning/memory/cond	1.39628586
41	MP0005187_abnormal_penis_morphology	1.39223871
42	MP0008789_abnormal_olfactory_epithelium	1.33375948
43	MP0000955_abnormal_spinal_cord	1.31823086
44	MP0002822_catalepsy	1.30988452
45	MP0001968_abnormal_touch/_nociception	1.29489670
46	MP0000383_abnormal_hair_follicle	1.28955050
47	MP0003136_yellow_coat_color	1.28605913
48	MP0005646_abnormal_pituitary_gland	1.27287328
49	MP0009780_abnormal_chondrocyte_physiolo	1.25957860
50	MP0005499_abnormal_olfactory_system	1.24476724
51	MP0005394_taste/olfaction_phenotype	1.24476724
52	MP0000647_abnormal_sebaceous_gland	1.24277705
53	MP0005386_behavior/neurological_phenoty	1.23873787
54	MP0004924_abnormal_behavior	1.23873787
55	MP0003937_abnormal_limbs/digits/tail_de	1.22982213
56	MP0005645_abnormal_hypothalamus_physiol	1.22868341
57	MP0002735_abnormal_chemical_nociception	1.19953418
58	MP0001501_abnormal_sleep_pattern	1.18404451
59	MP0002928_abnormal_bile_duct	1.17660514
60	MP0003698_abnormal_male_reproductive	1.15137496
61	MP0001502_abnormal_circadian_rhythm	1.14044401
62	MP0004885_abnormal_endolymph	1.12107741
63	MP0002882_abnormal_neuron_morphology	1.09048176
64	MP0002067_abnormal_sensory_capabilities	1.07817544
65	MP0003195_calcinosis	1.07718647
66	MP0001929_abnormal_gametogenesis	1.07396166
67	MP0005248_abnormal_Harderian_gland	1.07126869
68	MP0010678_abnormal_skin_adnexa	1.05574313
69	MP0004142_abnormal_muscle_tone	1.05110938
70	MP0000427_abnormal_hair_cycle	1.04749435
71	MP0003119_abnormal_digestive_system	1.03020318
72	MP0002210_abnormal_sex_determination	1.02829819
73	MP0002736_abnormal_nociception_after	1.01856076
74	MP0004043_abnormal_pH_regulation	0.99805219
75	MP0001970_abnormal_pain_threshold	0.97898226
76	MP0008875_abnormal_xenobiotic_pharmacok	0.97856634
77	MP0004147_increased_porphyrin_level	0.97110391
78	MP0000013_abnormal_adipose_tissue	0.96864096
79	MP0004811_abnormal_neuron_physiology	0.96518306
80	MP0010386_abnormal_urinary_bladder	0.96225189
81	MP0001485_abnormal_pinna_reflex	0.95436075
82	MP0005391_vision/eye_phenotype	0.95404869
83	MP0008995_early_reproductive_senescence	0.92489776
84	MP0002752_abnormal_somatic_nervous	0.92129140
85	MP0001944_abnormal_pancreas_morphology	0.90363963
86	MP0005379_endocrine/exocrine_gland_phen	0.89760664
87	MP0002152_abnormal_brain_morphology	0.89660223
88	MP0003861_abnormal_nervous_system	0.89499633
89	MP0000653_abnormal_sex_gland	0.89343636
90	MP0001293_anophthalmia	0.89321819
91	MP0001145_abnormal_male_reproductive	0.88955799
92	MP0002233_abnormal_nose_morphology	0.88178387
93	MP0003123_paternal_imprinting	0.87227038
94	MP0002751_abnormal_autonomic_nervous	0.82153014
95	MP0005389_reproductive_system_phenotype	0.81870870
96	MP0002229_neurodegeneration	0.79933982
97	MP0002876_abnormal_thyroid_physiology	0.79609520
98	MP0002733_abnormal_thermal_nociception	0.78936655
99	MP0001963_abnormal_hearing_physiology	0.77596660
100	MP0005195_abnormal_posterior_eye	0.77547634

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nephronophthisis (HP:0000090)	3.65472201
2	Type II lissencephaly (HP:0007260)	3.38274817
3	Abnormality of midbrain morphology (HP:0002418)	3.34415569
4	Molar tooth sign on MRI (HP:0002419)	3.34415569
5	Cerebellar dysplasia (HP:0007033)	3.27722786
6	Pancreatic cysts (HP:0001737)	3.26023455
7	True hermaphroditism (HP:0010459)	3.24472239
8	Pancreatic fibrosis (HP:0100732)	3.19389509
9	Medial flaring of the eyebrow (HP:0010747)	3.11873052
10	Gait imbalance (HP:0002141)	3.11340115
11	Abnormality of the renal medulla (HP:0100957)	3.08086847
12	Chronic hepatic failure (HP:0100626)	3.05808374
13	Oligodactyly (hands) (HP:0001180)	2.96511141
14	Volvulus (HP:0002580)	2.96164573
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.95019993
16	Congenital primary aphakia (HP:0007707)	2.91743560
17	Focal motor seizures (HP:0011153)	2.88690806
18	Abnormality of the renal cortex (HP:0011035)	2.79371391
19	Tubulointerstitial nephritis (HP:0001970)	2.75480466
20	Abnormal respiratory motile cilium physiology (HP:0012261)	2.72319977
21	Abnormal respiratory epithelium morphology (HP:0012253)	2.72011954
22	Abnormal respiratory motile cilium morphology (HP:0005938)	2.72011954
23	Abnormal ciliary motility (HP:0012262)	2.71854553
24	Hypothermia (HP:0002045)	2.71377291
25	Nephrogenic diabetes insipidus (HP:0009806)	2.64803082
26	Occipital encephalocele (HP:0002085)	2.58136847
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55904830
28	Absent/shortened dynein arms (HP:0200106)	2.55904830
29	Hyperventilation (HP:0002883)	2.52137911
30	Rhinitis (HP:0012384)	2.51731247
31	Lissencephaly (HP:0001339)	2.49706871
32	Tubular atrophy (HP:0000092)	2.46530407
33	Genital tract atresia (HP:0001827)	2.41414578
34	Postaxial foot polydactyly (HP:0001830)	2.38451874
35	Vaginal atresia (HP:0000148)	2.35848370
36	Drooling (HP:0002307)	2.32661261
37	Limb dystonia (HP:0002451)	2.30182181
38	Cystic liver disease (HP:0006706)	2.29551596
39	Oligodactyly (HP:0012165)	2.23903158
40	Focal seizures (HP:0007359)	2.16982407
41	Postaxial hand polydactyly (HP:0001162)	2.16197794
42	Tubulointerstitial abnormality (HP:0001969)	2.15128681
43	Retinal dysplasia (HP:0007973)	2.13260172
44	Febrile seizures (HP:0002373)	2.12035926
45	Broad-based gait (HP:0002136)	2.03719320
46	Intestinal atresia (HP:0011100)	2.03090625
47	Abnormality of the corticospinal tract (HP:0002492)	2.02740424
48	Agitation (HP:0000713)	2.01922677
49	Proximal tubulopathy (HP:0000114)	2.01598358
50	Epileptic encephalopathy (HP:0200134)	2.00685047
51	Excessive salivation (HP:0003781)	2.00493989
52	Preaxial hand polydactyly (HP:0001177)	1.97168944
53	Myokymia (HP:0002411)	1.96379709
54	Hypsarrhythmia (HP:0002521)	1.95092650
55	Poor coordination (HP:0002370)	1.94240414
56	Epileptiform EEG discharges (HP:0011182)	1.93388654
57	EEG with generalized epileptiform discharges (HP:0011198)	1.91471776
58	Sclerocornea (HP:0000647)	1.89489715
59	Abnormal drinking behavior (HP:0030082)	1.88778346
60	Polydipsia (HP:0001959)	1.88778346
61	Optic nerve hypoplasia (HP:0000609)	1.87643461
62	Specific learning disability (HP:0001328)	1.86445321
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.85748604
64	Pheochromocytoma (HP:0002666)	1.85502219
65	Absent speech (HP:0001344)	1.84352037
66	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.83768729
67	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.83768729
68	Dialeptic seizures (HP:0011146)	1.82601267
69	Congenital stationary night blindness (HP:0007642)	1.81771458
70	Male pseudohermaphroditism (HP:0000037)	1.80289648
71	Pachygyria (HP:0001302)	1.80105302
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78604340
73	Renal cortical cysts (HP:0000803)	1.77995738
74	Congenital hepatic fibrosis (HP:0002612)	1.75336629
75	Hypoplasia of the brainstem (HP:0002365)	1.74353299
76	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.74353299
77	Anencephaly (HP:0002323)	1.73472695
78	Aplasia/Hypoplasia of the lens (HP:0008063)	1.73268412
79	Short tibia (HP:0005736)	1.72795632
80	Labial hypoplasia (HP:0000066)	1.71014533
81	Generalized tonic-clonic seizures (HP:0002069)	1.69459865
82	Neuroendocrine neoplasm (HP:0100634)	1.69318279
83	Stage 5 chronic kidney disease (HP:0003774)	1.69316516
84	Hemiparesis (HP:0001269)	1.68439237
85	Polyphagia (HP:0002591)	1.66117586
86	Menstrual irregularities (HP:0000858)	1.65822833
87	Median cleft lip (HP:0000161)	1.63319666
88	Anophthalmia (HP:0000528)	1.63191759
89	Inability to walk (HP:0002540)	1.62314364
90	Atonic seizures (HP:0010819)	1.60734451
91	Prominent nasal bridge (HP:0000426)	1.60011934
92	Amblyopia (HP:0000646)	1.58396470
93	Multicystic kidney dysplasia (HP:0000003)	1.58117772
94	Tubulointerstitial fibrosis (HP:0005576)	1.57639825
95	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.56331823
96	Retinitis pigmentosa (HP:0000510)	1.56271361
97	Morphological abnormality of the pyramidal tract (HP:0002062)	1.55415767
98	Severe muscular hypotonia (HP:0006829)	1.54649735
99	Progressive cerebellar ataxia (HP:0002073)	1.53363893
100	Absence seizures (HP:0002121)	1.52318373

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	3.92004242
2	PNCK	3.60829346
3	MAP3K4	2.89744639
4	FRK	2.89048218
5	MARK1	2.86694731
6	MAP2K7	2.43071722
7	MAPK15	2.09094058
8	EPHA3	2.07076088
9	STK38L	2.04106779
10	MAP4K2	2.02062754
11	ACVR1B	1.85075632
12	ZAK	1.83807290
13	MAPK13	1.82364870
14	PINK1	1.81769574
15	WNK3	1.78083090
16	BMPR1B	1.76526442
17	BCR	1.75514856
18	TRIM28	1.72757704
19	EPHA4	1.67073211
20	ERBB3	1.67072984
21	NTRK3	1.63935604
22	WNK4	1.56818572
23	CSNK1G2	1.48151067
24	ADRBK2	1.39989662
25	MAP2K4	1.39762148
26	GRK1	1.37390447
27	CDK19	1.32380607
28	CSNK1G3	1.30585247
29	NTRK2	1.28381649
30	CSNK1G1	1.24508292
31	DYRK2	1.21607158
32	CSNK1A1L	1.21480192
33	PLK2	1.21111644
34	MUSK	1.20600009
35	PRKD3	1.18021088
36	PHKG2	1.16431183
37	PHKG1	1.16431183
38	CAMK1G	1.12355250
39	EIF2AK3	1.09828343
40	WEE1	1.07700385
41	LATS1	1.07051717
42	MINK1	1.03947287
43	MET	1.01738524
44	STK39	1.01734666
45	PRKCG	1.00336627
46	DAPK2	1.00123227
47	OXSR1	0.99007930
48	CAMKK2	0.96128300
49	UHMK1	0.93236860
50	BRSK2	0.93155763
51	PAK3	0.90024301
52	PRKCE	0.87689639
53	INSRR	0.87340924
54	TNIK	0.85577604
55	TSSK6	0.84464620
56	FGFR2	0.81458068
57	VRK1	0.76649685
58	TLK1	0.73022777
59	AKT3	0.69184261
60	PAK6	0.65819466
61	PTK2B	0.65612132
62	STK38	0.65466295
63	CAMK2A	0.65266753
64	PLK3	0.60970239
65	SGK494	0.59258004
66	SGK223	0.59258004
67	PRKAA1	0.59130868
68	MST4	0.58770586
69	SIK2	0.57113244
70	PLK1	0.56175786
71	DYRK1A	0.54383065
72	PKN1	0.54116579
73	MAP2K6	0.50534651
74	CCNB1	0.50143354
75	CAMK1	0.50111244
76	PLK4	0.49718544
77	FER	0.49691201
78	BRD4	0.49664291
79	STK3	0.49483537
80	CDK5	0.49246807
81	CAMKK1	0.47874469
82	MAP3K2	0.47403440
83	NEK1	0.46232277
84	LIMK1	0.45833660
85	ADRBK1	0.45588397
86	TTK	0.44245317
87	CSNK1E	0.43783294
88	RET	0.43142917
89	DYRK3	0.42734683
90	CDK3	0.42452086
91	BRSK1	0.41972699
92	LATS2	0.40951767
93	SRPK1	0.40105586
94	CAMK2B	0.38065511
95	MKNK2	0.37221850
96	PRKCZ	0.36529061
97	ATM	0.36303322
98	CSNK1A1	0.35337450
99	PRKCI	0.35075467
100	PDK2	0.34873453

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.05757709
2	Nicotine addiction_Homo sapiens_hsa05033	3.05354319
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34563930
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28260033
5	Butanoate metabolism_Homo sapiens_hsa00650	2.24641840
6	Steroid biosynthesis_Homo sapiens_hsa00100	1.97007802
7	Protein export_Homo sapiens_hsa03060	1.95808215
8	Phototransduction_Homo sapiens_hsa04744	1.95057246
9	GABAergic synapse_Homo sapiens_hsa04727	1.80276727
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74160617
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.72843950
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68548352
13	Insulin secretion_Homo sapiens_hsa04911	1.66810394
14	Circadian rhythm_Homo sapiens_hsa04710	1.59815132
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57742097
16	Taste transduction_Homo sapiens_hsa04742	1.53937466
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.47332143
18	Circadian entrainment_Homo sapiens_hsa04713	1.47210571
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.47077750
20	Morphine addiction_Homo sapiens_hsa05032	1.46182494
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.44345575
22	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.43890217
23	Propanoate metabolism_Homo sapiens_hsa00640	1.39822708
24	Dopaminergic synapse_Homo sapiens_hsa04728	1.38610099
25	Cocaine addiction_Homo sapiens_hsa05030	1.38291023
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29923851
27	Basal transcription factors_Homo sapiens_hsa03022	1.19233886
28	Peroxisome_Homo sapiens_hsa04146	1.15892189
29	Amphetamine addiction_Homo sapiens_hsa05031	1.13418433
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13151808
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.11859658
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.11565956
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.10221250
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.09616016
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.07821238
36	Serotonergic synapse_Homo sapiens_hsa04726	1.07670430
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.07033184
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.04060030
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.04023372
40	Oocyte meiosis_Homo sapiens_hsa04114	0.96299257
41	Fatty acid elongation_Homo sapiens_hsa00062	0.95873270
42	Regulation of autophagy_Homo sapiens_hsa04140	0.94586834
43	Basal cell carcinoma_Homo sapiens_hsa05217	0.94321479
44	Axon guidance_Homo sapiens_hsa04360	0.93438803
45	Oxidative phosphorylation_Homo sapiens_hsa00190	0.92014116
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90866474
47	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.89684887
48	Alcoholism_Homo sapiens_hsa05034	0.88974491
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86582189
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.86129476
51	Huntingtons disease_Homo sapiens_hsa05016	0.85369361
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.84330103
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82913823
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80210053
55	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.79582316
56	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.79064040
57	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.79055172
58	ABC transporters_Homo sapiens_hsa02010	0.78308305
59	Olfactory transduction_Homo sapiens_hsa04740	0.77855258
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.76592945
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74335106
62	Salivary secretion_Homo sapiens_hsa04970	0.73646550
63	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73018879
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72247785
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70515564
66	Parkinsons disease_Homo sapiens_hsa05012	0.70432311
67	Long-term depression_Homo sapiens_hsa04730	0.70201102
68	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69584031
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67981873
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66619758
71	RNA degradation_Homo sapiens_hsa03018	0.66054021
72	Cholinergic synapse_Homo sapiens_hsa04725	0.65943622
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.65737604
74	Type II diabetes mellitus_Homo sapiens_hsa04930	0.65449011
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63852828
76	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63474270
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62589955
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.62545349
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.60926014
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58928014
81	Folate biosynthesis_Homo sapiens_hsa00790	0.58861417
82	Calcium signaling pathway_Homo sapiens_hsa04020	0.58406989
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58219818
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57824474
85	Sulfur metabolism_Homo sapiens_hsa00920	0.57782865
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.56436956
87	Fatty acid degradation_Homo sapiens_hsa00071	0.56039603
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55508060
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54469931
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.54264000
91	Tyrosine metabolism_Homo sapiens_hsa00350	0.53970595
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53578028
93	Bile secretion_Homo sapiens_hsa04976	0.53231220
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.51304143
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.50840214
96	Histidine metabolism_Homo sapiens_hsa00340	0.50357527
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.50181009
98	Retinol metabolism_Homo sapiens_hsa00830	0.49926745
99	Metabolic pathways_Homo sapiens_hsa01100	0.49196596
100	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47241451

KIAA0895

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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