KIAA0907

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.60065528
2nuclear pore organization (GO:0006999)6.86939374
3regulation of histone H3-K27 methylation (GO:0061085)5.79329680
4pore complex assembly (GO:0046931)5.44808255
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)5.10762779
6mitotic sister chromatid cohesion (GO:0007064)5.08310149
7DNA replication checkpoint (GO:0000076)4.89596598
8regulation of histone H3-K4 methylation (GO:0051569)4.73926540
9negative regulation of mRNA processing (GO:0050686)4.69088285
10histone H3-K4 trimethylation (GO:0080182)4.65134524
11regulation of RNA export from nucleus (GO:0046831)4.57579103
12mitotic chromosome condensation (GO:0007076)4.49981731
13meiotic chromosome segregation (GO:0045132)4.37494456
14negative regulation of mRNA metabolic process (GO:1903312)4.33349962
15sister chromatid segregation (GO:0000819)4.29805191
16negative regulation of histone methylation (GO:0031061)4.29307668
17mitotic sister chromatid segregation (GO:0000070)4.24328435
18monoubiquitinated protein deubiquitination (GO:0035520)4.20640428
19DNA unwinding involved in DNA replication (GO:0006268)4.18955940
20regulation of translational fidelity (GO:0006450)4.08180949
21regulation of centriole replication (GO:0046599)4.00013333
22mitotic nuclear envelope disassembly (GO:0007077)3.97036863
23DNA duplex unwinding (GO:0032508)3.91411890
24regulation of centrosome duplication (GO:0010824)3.90732765
25regulation of histone methylation (GO:0031060)3.86341239
26DNA geometric change (GO:0032392)3.81859739
27negative regulation of RNA splicing (GO:0033119)3.79385511
28mRNA cleavage (GO:0006379)3.79135450
29nuclear envelope disassembly (GO:0051081)3.79128580
30membrane disassembly (GO:0030397)3.79128580
31intra-S DNA damage checkpoint (GO:0031573)3.75955460
32peptidyl-lysine trimethylation (GO:0018023)3.67028060
33positive regulation of histone H3-K4 methylation (GO:0051571)3.66097664
34regulation of centrosome cycle (GO:0046605)3.64711484
35DNA replication initiation (GO:0006270)3.64179164
36DNA synthesis involved in DNA repair (GO:0000731)3.62852046
37histone H3-K4 methylation (GO:0051568)3.59342060
38mRNA transport (GO:0051028)3.56538993
39regulation of DNA damage checkpoint (GO:2000001)3.54019761
40regulation of nucleobase-containing compound transport (GO:0032239)3.52873090
41kinetochore organization (GO:0051383)3.48634746
42sister chromatid cohesion (GO:0007062)3.48155638
43pre-miRNA processing (GO:0031054)3.47842509
44mRNA export from nucleus (GO:0006406)3.47226579
45histone H4-K16 acetylation (GO:0043984)3.46051842
46positive regulation of cell cycle checkpoint (GO:1901978)3.41863538
47regulation of DNA endoreduplication (GO:0032875)3.39217263
48peptidyl-lysine methylation (GO:0018022)3.38846320
49DNA conformation change (GO:0071103)3.38475711
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.36943565
51DNA topological change (GO:0006265)3.32761925
52cytoplasmic mRNA processing body assembly (GO:0033962)3.31470881
53nuclear envelope organization (GO:0006998)3.31105346
54histone lysine methylation (GO:0034968)3.28057584
55RNA export from nucleus (GO:0006405)3.28019415
56positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.18276030
57inner cell mass cell proliferation (GO:0001833)3.17968332
58termination of RNA polymerase II transcription (GO:0006369)3.16530046
59corticosteroid receptor signaling pathway (GO:0031958)3.15173861
60nucleic acid transport (GO:0050657)3.11683977
61RNA transport (GO:0050658)3.11683977
62establishment of RNA localization (GO:0051236)3.11683977
63chromosome condensation (GO:0030261)3.11678666
64glucocorticoid receptor signaling pathway (GO:0042921)3.10995003
65mRNA splice site selection (GO:0006376)3.09595184
66dosage compensation (GO:0007549)3.07780727
67regulation of chromatin binding (GO:0035561)3.03272902
68heterochromatin organization (GO:0070828)2.93821854
69positive regulation of histone methylation (GO:0031062)2.92770518
70protein export from nucleus (GO:0006611)2.90342315
71histone deubiquitination (GO:0016578)2.90022686
72DNA packaging (GO:0006323)2.87980881
73DNA strand elongation involved in DNA replication (GO:0006271)2.86600183
74nuclear export (GO:0051168)2.86210451
75histone H4-K8 acetylation (GO:0043982)2.86162481
76histone H4-K5 acetylation (GO:0043981)2.86162481
77histone methylation (GO:0016571)2.85275657
78protein localization to kinetochore (GO:0034501)2.85184375
79regulation of histone H3-K9 methylation (GO:0051570)2.81979548
80ribosome assembly (GO:0042255)2.80712090
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75569076
82regulation of DNA-dependent DNA replication (GO:0090329)2.73720780
83poly(A)+ mRNA export from nucleus (GO:0016973)2.73470956
84histone H3-K9 methylation (GO:0051567)2.72598650
85histone H3-K9 modification (GO:0061647)2.72439546
86protein localization to chromosome, centromeric region (GO:0071459)2.72402359
87mRNA 3-end processing (GO:0031124)2.71070589
88DNA strand elongation (GO:0022616)2.70084509
89negative regulation of histone modification (GO:0031057)2.69516103
90regulation of mRNA splicing, via spliceosome (GO:0048024)2.67944715
91regulation of nuclear cell cycle DNA replication (GO:0033262)2.67244456
92positive regulation of DNA-dependent DNA replication (GO:2000105)2.67120690
93negative regulation of chromatin modification (GO:1903309)2.66418623
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65101698
95nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.63174633
96stress granule assembly (GO:0034063)2.63081459
97folic acid-containing compound biosynthetic process (GO:0009396)2.62473325
98snRNA metabolic process (GO:0016073)2.61898610
99replication fork processing (GO:0031297)2.59916276
100positive regulation of RNA splicing (GO:0033120)2.59877001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.24061846
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31096012
3KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.96887313
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.47246467
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.15820179
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08188424
7E2F1_21310950_ChIP-Seq_MCF-7_Human3.07410780
8MYC_22102868_ChIP-Seq_BL_Human2.87677345
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48002826
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.46077350
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.44423650
12YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43732672
13* KDM5A_27292631_Chip-Seq_BREAST_Human2.43538301
14* CIITA_25753668_ChIP-Seq_RAJI_Human2.43335082
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36113029
16AR_21909140_ChIP-Seq_LNCAP_Human2.21928153
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.15818805
18CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.05661360
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05424550
20PKCTHETA_26484144_Chip-Seq_BREAST_Human2.04942555
21E2F7_22180533_ChIP-Seq_HELA_Human11.1064297
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.98347296
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93388963
24* XRN2_22483619_ChIP-Seq_HELA_Human1.88156866
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83594631
26DCP1A_22483619_ChIP-Seq_HELA_Human1.82194982
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.80236836
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77804909
29CHD1_26751641_Chip-Seq_LNCaP_Human1.75513539
30* TTF2_22483619_ChIP-Seq_HELA_Human1.73866537
31FUS_26573619_Chip-Seq_HEK293_Human1.63967263
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62160463
33CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61775228
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61757004
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58777696
36FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.48842124
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48489548
38* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45907276
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44664703
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38635977
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38128525
42ELK1_19687146_ChIP-ChIP_HELA_Human1.37395243
43CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35234866
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33688735
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31613883
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.31340483
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31175096
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30990653
49* GATA6_25053715_ChIP-Seq_YYC3_Human1.27229849
50* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.25209518
51VDR_23849224_ChIP-Seq_CD4+_Human1.23078580
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.20743911
53* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19754178
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18694901
55* ETS1_20019798_ChIP-Seq_JURKAT_Human1.17301214
56* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15352177
57GABP_19822575_ChIP-Seq_HepG2_Human1.14079952
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12893360
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11761577
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10982457
61GATA1_22025678_ChIP-Seq_K562_Human1.10782680
62TFEB_21752829_ChIP-Seq_HELA_Human1.10570763
63NCOR1_26117541_ChIP-Seq_K562_Human1.07012729
64EWS_26573619_Chip-Seq_HEK293_Human1.06052791
65* MYB_26560356_Chip-Seq_TH1_Human1.03846095
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02711750
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00691542
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92910053
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92008021
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89705222
71THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88693067
72* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88364966
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87748123
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87303553
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87199102
76KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86149097
77NANOG_21062744_ChIP-ChIP_HESCs_Human0.84060276
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83542771
79ZNF263_19887448_ChIP-Seq_K562_Human0.83399904
80RUNX1_27514584_Chip-Seq_MCF-7_Human0.81979704
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80803604
82TCF7_22412390_ChIP-Seq_EML_Mouse0.79446692
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78896309
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77641595
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75670918
86WT1_19549856_ChIP-ChIP_CCG9911_Human0.75659346
87* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.75185438
88ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74378633
89* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72816180
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71986398
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.71830479
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.66542930
93VDR_21846776_ChIP-Seq_THP-1_Human0.66433600
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.65534057
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.65328434
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.64881995
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.64367472
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.63474220
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.63121780
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.62228750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.85441678
2MP0010094_abnormal_chromosome_stability4.37380993
3MP0003111_abnormal_nucleus_morphology3.55268540
4MP0002009_preneoplasia3.45073064
5MP0002396_abnormal_hematopoietic_system2.99439544
6MP0008058_abnormal_DNA_repair2.89519993
7MP0003693_abnormal_embryo_hatching2.88313950
8MP0003077_abnormal_cell_cycle2.75737422
9MP0004957_abnormal_blastocyst_morpholog2.70836747
10MP0008961_abnormal_basal_metabolism2.41315218
11MP0010307_abnormal_tumor_latency2.24875948
12MP0008007_abnormal_cellular_replicative2.13987472
13MP0005076_abnormal_cell_differentiation1.98969016
14MP0004808_abnormal_hematopoietic_stem1.95465196
15MP0003786_premature_aging1.90186058
16MP0000350_abnormal_cell_proliferation1.88805678
17MP0000566_synostosis1.83066367
18MP0003890_abnormal_embryonic-extraembry1.80232276
19MP0001730_embryonic_growth_arrest1.79876903
20MP0008995_early_reproductive_senescence1.79703251
21MP0010352_gastrointestinal_tract_polyps1.72347632
22MP0003984_embryonic_growth_retardation1.71903297
23MP0008932_abnormal_embryonic_tissue1.69468139
24MP0001672_abnormal_embryogenesis/_devel1.67618028
25MP0005380_embryogenesis_phenotype1.67618028
26MP0002088_abnormal_embryonic_growth/wei1.67449952
27MP0000569_abnormal_digit_pigmentation1.65333991
28MP0010234_abnormal_vibrissa_follicle1.62020807
29MP0000003_abnormal_adipose_tissue1.55693087
30MP0002084_abnormal_developmental_patter1.54825928
31MP0002166_altered_tumor_susceptibility1.54523690
32MP0005083_abnormal_biliary_tract1.51619888
33MP0004264_abnormal_extraembryonic_tissu1.50549035
34MP0001697_abnormal_embryo_size1.49808743
35MP0004197_abnormal_fetal_growth/weight/1.49376350
36MP0003943_abnormal_hepatobiliary_system1.44975245
37MP0004043_abnormal_pH_regulation1.44951873
38MP0005220_abnormal_exocrine_pancreas1.39435634
39MP0004233_abnormal_muscle_weight1.35829165
40MP0001661_extended_life_span1.33940590
41MP0002085_abnormal_embryonic_tissue1.31899919
42MP0003937_abnormal_limbs/digits/tail_de1.31208475
43MP0002086_abnormal_extraembryonic_tissu1.29889550
44MP0000313_abnormal_cell_death1.25420097
45MP0002080_prenatal_lethality1.25182827
46MP0004185_abnormal_adipocyte_glucose1.24285097
47MP0002249_abnormal_larynx_morphology1.18536976
48MP0009672_abnormal_birth_weight1.16714793
49MP0001346_abnormal_lacrimal_gland1.16347714
50MP0010678_abnormal_skin_adnexa1.12812538
51MP0000383_abnormal_hair_follicle1.12618333
52MP0002006_tumorigenesis1.11507113
53MP0003221_abnormal_cardiomyocyte_apopto1.04242364
54MP0009703_decreased_birth_body1.02110588
55MP0008775_abnormal_heart_ventricle1.01322232
56MP0003567_abnormal_fetal_cardiomyocyte0.98495430
57MP0005187_abnormal_penis_morphology0.98012905
58MP0003935_abnormal_craniofacial_develop0.92733776
59MP0003115_abnormal_respiratory_system0.91381149
60MP0004782_abnormal_surfactant_physiolog0.91005488
61MP0000703_abnormal_thymus_morphology0.89295344
62MP0000428_abnormal_craniofacial_morphol0.89135229
63MP0005375_adipose_tissue_phenotype0.87720100
64MP0002019_abnormal_tumor_incidence0.87262656
65MP0005645_abnormal_hypothalamus_physiol0.86568559
66MP0008877_abnormal_DNA_methylation0.86403577
67MP0006035_abnormal_mitochondrial_morpho0.85431236
68MP0002697_abnormal_eye_size0.84333326
69MP0002210_abnormal_sex_determination0.82792635
70MP0001944_abnormal_pancreas_morphology0.82713217
71MP0002970_abnormal_white_adipose0.81855997
72MP0003656_abnormal_erythrocyte_physiolo0.80671255
73MP0001929_abnormal_gametogenesis0.80465008
74MP0001286_abnormal_eye_development0.79269104
75MP0001145_abnormal_male_reproductive0.78715268
76MP0002877_abnormal_melanocyte_morpholog0.77998759
77MP0000678_abnormal_parathyroid_gland0.77199378
78MP0002925_abnormal_cardiovascular_devel0.77153985
79MP0001873_stomach_inflammation0.76863095
80MP0009115_abnormal_fat_cell0.74273551
81MP0010630_abnormal_cardiac_muscle0.74213442
82MP0003861_abnormal_nervous_system0.73464760
83MP0000432_abnormal_head_morphology0.71179345
84MP0000358_abnormal_cell_content/0.70437779
85MP0003646_muscle_fatigue0.69272450
86MP0000490_abnormal_crypts_of0.67541966
87MP0000653_abnormal_sex_gland0.67212179
88MP0002114_abnormal_axial_skeleton0.67145601
89MP0002111_abnormal_tail_morphology0.67106042
90MP0005666_abnormal_adipose_tissue0.65028014
91MP0002098_abnormal_vibrissa_morphology0.64353919
92MP0002234_abnormal_pharynx_morphology0.63870188
93MP0000427_abnormal_hair_cycle0.62101764
94MP0003763_abnormal_thymus_physiology0.61341961
95MP0003698_abnormal_male_reproductive0.60578521
96MP0003699_abnormal_female_reproductive0.60481412
97MP0005621_abnormal_cell_physiology0.60023357
98MP0000537_abnormal_urethra_morphology0.59573762
99MP0005384_cellular_phenotype0.59203307
100MP0001784_abnormal_fluid_regulation0.59046141

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.63136554
2Chromsome breakage (HP:0040012)5.58244488
3Abnormality of the fingertips (HP:0001211)4.26661115
4Acute lymphatic leukemia (HP:0006721)4.03560769
5Homocystinuria (HP:0002156)3.76308468
6Abnormality of homocysteine metabolism (HP:0010919)3.76308468
7Septate vagina (HP:0001153)3.66523454
8Overlapping toe (HP:0001845)3.54553941
9Duplicated collecting system (HP:0000081)3.35006129
10Volvulus (HP:0002580)3.22825728
11Birth length less than 3rd percentile (HP:0003561)3.07913493
12Lip pit (HP:0100267)3.04854104
13Acute myeloid leukemia (HP:0004808)3.03248628
14Abnormality of chromosome segregation (HP:0002916)3.03002373
15Abnormality of chromosome stability (HP:0003220)2.98142584
16Abnormality of the renal collecting system (HP:0004742)2.96573195
17Sandal gap (HP:0001852)2.87119529
18Ectopic kidney (HP:0000086)2.75369860
19Increased nuchal translucency (HP:0010880)2.62491837
20Ankyloglossia (HP:0010296)2.61619723
21Abnormality of cochlea (HP:0000375)2.60158858
22Heterotopia (HP:0002282)2.57479374
23Hypoplastic labia majora (HP:0000059)2.53313129
24Long eyelashes (HP:0000527)2.51715450
25Sparse lateral eyebrow (HP:0005338)2.49360022
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.45092157
27Progressive external ophthalmoplegia (HP:0000590)2.44906681
28Obsessive-compulsive behavior (HP:0000722)2.43521074
29Abnormality of the preputium (HP:0100587)2.42896154
30Abnormality of the labia majora (HP:0012881)2.32279827
31Myelodysplasia (HP:0002863)2.30815397
32Clubbing of toes (HP:0100760)2.28227272
33Abnormality of the ileum (HP:0001549)2.26553119
34Cafe-au-lait spot (HP:0000957)2.21934797
35Absent radius (HP:0003974)2.21287572
36Squamous cell carcinoma (HP:0002860)2.21273440
37Low anterior hairline (HP:0000294)2.20567110
38Meckel diverticulum (HP:0002245)2.20048688
39Nephroblastoma (Wilms tumor) (HP:0002667)2.19160127
40Dysmetric saccades (HP:0000641)2.17220755
41Sloping forehead (HP:0000340)2.14941506
42Deep philtrum (HP:0002002)2.14910524
43Abnormality of the carotid arteries (HP:0005344)2.13706081
44Abnormality of DNA repair (HP:0003254)2.13134942
45Pseudobulbar signs (HP:0002200)2.03456416
46Pancreatic islet-cell hyperplasia (HP:0004510)2.00994803
47Absent forearm bone (HP:0003953)1.99498076
48Aplasia involving forearm bones (HP:0009822)1.99498076
49Depressed nasal tip (HP:0000437)1.99323127
50Oligodontia (HP:0000677)1.99180974
51Limb hypertonia (HP:0002509)1.98869927
52Ureteral duplication (HP:0000073)1.98479495
53Embryonal renal neoplasm (HP:0011794)1.98218124
54Prominent nose (HP:0000448)1.96419679
55Curly hair (HP:0002212)1.95459125
56Macroorchidism (HP:0000053)1.89871910
57Abnormality of the nasal septum (HP:0000419)1.89445482
58Duodenal stenosis (HP:0100867)1.89427455
59Small intestinal stenosis (HP:0012848)1.89427455
60Submucous cleft hard palate (HP:0000176)1.89139281
61Anal stenosis (HP:0002025)1.88978002
62Microvesicular hepatic steatosis (HP:0001414)1.87229226
63Abnormal number of incisors (HP:0011064)1.87149993
64Abnormality of oral frenula (HP:0000190)1.85781054
65Central scotoma (HP:0000603)1.83809974
66Blepharophimosis (HP:0000581)1.82850711
67Optic nerve coloboma (HP:0000588)1.81841804
68Abnormality of endocrine pancreas physiology (HP:0012093)1.81643604
69Abnormality of the pancreatic islet cells (HP:0006476)1.81643604
70Short chin (HP:0000331)1.80074599
71Tapered finger (HP:0001182)1.76248513
72Patellar aplasia (HP:0006443)1.76104043
73Morphological abnormality of the inner ear (HP:0011390)1.74701223
74Protruding tongue (HP:0010808)1.74481093
75Truncal obesity (HP:0001956)1.74463761
76Thick eyebrow (HP:0000574)1.72966358
77Intestinal malrotation (HP:0002566)1.72695017
78Persistence of primary teeth (HP:0006335)1.71546820
79Cutis marmorata (HP:0000965)1.70907047
80Arteriovenous malformation (HP:0100026)1.69573733
81Short middle phalanx of finger (HP:0005819)1.69188448
82Asymmetry of the thorax (HP:0001555)1.69057874
83Fair hair (HP:0002286)1.67306410
84Bowel incontinence (HP:0002607)1.65876262
85Progressive muscle weakness (HP:0003323)1.65652128
86Metaphyseal cupping (HP:0003021)1.64151993
87Choanal atresia (HP:0000453)1.63365523
88Broad palm (HP:0001169)1.62907255
89Short thumb (HP:0009778)1.61539336
90Cutaneous melanoma (HP:0012056)1.60323588
91Abnormality of methionine metabolism (HP:0010901)1.60214083
92Broad nasal tip (HP:0000455)1.59853952
93Smooth philtrum (HP:0000319)1.59521988
94Tubular atrophy (HP:0000092)1.57223340
95Truncus arteriosus (HP:0001660)1.56711592
96Atresia of the external auditory canal (HP:0000413)1.56609903
97Diastasis recti (HP:0001540)1.56219874
98Congenital stationary night blindness (HP:0007642)1.56088794
99Cubitus valgus (HP:0002967)1.55976516
100Aplasia/Hypoplasia of the patella (HP:0006498)1.55555120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD44.61258354
2CDK124.38948980
3EEF2K3.33639934
4MKNK22.41639524
5BRSK22.36146551
6MAP3K102.29286930
7TRIB32.25367290
8WEE12.24831046
9CDC72.23830559
10EIF2AK32.20242916
11SRPK12.11791866
12PNCK2.02086274
13CAMK1G1.91289456
14FRK1.86301659
15MKNK11.82589995
16TTK1.79007412
17ATR1.66631075
18ICK1.63697817
19SIK21.55652634
20NEK21.52847941
21RPS6KB21.50809413
22AKT31.49022837
23CAMK1D1.44628068
24SMG11.36657490
25MAP3K131.34072064
26TAF11.33508798
27EIF2AK11.29930835
28CHEK21.29703964
29MAPK111.23278882
30CHEK11.22776570
31BUB11.18096003
32MTOR1.17514090
33FGFR41.16965086
34PLK41.14927462
35LATS11.14359551
36KSR21.13643909
37TRPM71.11203113
38MAP3K21.08542659
39MST1R1.07873545
40STK31.05888167
41PKN21.04430936
42CLK11.02405189
43RAF11.00728848
44ATM0.98794663
45STK240.97378076
46FGFR20.91352489
47ERBB30.90061651
48ACVR1B0.88268297
49CDK40.88129512
50BRSK10.82756533
51MET0.82465097
52MELK0.82376931
53CDK70.81687292
54CDK20.80984074
55TSSK60.80874565
56RPS6KB10.80089068
57SIK30.79328889
58YES10.78837175
59MAP3K70.78111870
60WNK40.76156442
61KSR10.75627375
62FGFR30.74277766
63CDK10.73941039
64MAP3K140.73462500
65PASK0.72889518
66PDK20.71215795
67MAPKAPK30.68809296
68SIK10.66452498
69PRKAA10.63428333
70MAP3K90.62124008
71ALK0.61092683
72WNK10.59792352
73EIF2AK20.58987569
74CDK60.57720664
75DYRK30.57226383
76PRKAA20.57153370
77CDC42BPA0.55062632
78AURKB0.53617513
79MAPK100.53106905
80PLK10.52337251
81PRKDC0.51440137
82CSNK1E0.50957082
83GSK3B0.50271421
84MAPK140.46233097
85CDK30.45303106
86BCKDK0.44876880
87CHUK0.43783832
88AKT10.43744251
89CCNB10.40156239
90SGK10.39351945
91IRAK30.39157404
92MAPK80.38800332
93NTRK30.38589524
94MAPK10.38465908
95NME10.38146355
96FLT30.36249511
97ERBB40.33632041
98FGFR10.33551708
99ZAK0.32679555
100PRPF4B0.31266477

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.24060069
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98448256
3mRNA surveillance pathway_Homo sapiens_hsa030152.81434571
4DNA replication_Homo sapiens_hsa030302.71744843
5Lysine degradation_Homo sapiens_hsa003102.70755714
6One carbon pool by folate_Homo sapiens_hsa006702.69789009
7Spliceosome_Homo sapiens_hsa030402.68097666
8RNA transport_Homo sapiens_hsa030132.66527893
9Cell cycle_Homo sapiens_hsa041102.57731768
10Fanconi anemia pathway_Homo sapiens_hsa034602.55359901
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42327291
12Homologous recombination_Homo sapiens_hsa034402.34479671
13Selenocompound metabolism_Homo sapiens_hsa004501.83112439
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.78397013
15Mismatch repair_Homo sapiens_hsa034301.75859191
16RNA degradation_Homo sapiens_hsa030181.71264881
17Chronic myeloid leukemia_Homo sapiens_hsa052201.67308280
18Base excision repair_Homo sapiens_hsa034101.61765603
19Nucleotide excision repair_Homo sapiens_hsa034201.57056489
20mTOR signaling pathway_Homo sapiens_hsa041501.46493537
21Basal transcription factors_Homo sapiens_hsa030221.44370935
22MicroRNAs in cancer_Homo sapiens_hsa052061.42396553
23Non-small cell lung cancer_Homo sapiens_hsa052231.41021599
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39426617
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25823501
26Prostate cancer_Homo sapiens_hsa052151.23062437
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20497844
28Thyroid cancer_Homo sapiens_hsa052161.17621981
29Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.17595180
30ErbB signaling pathway_Homo sapiens_hsa040121.17040266
31Circadian rhythm_Homo sapiens_hsa047101.17036928
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14830141
33p53 signaling pathway_Homo sapiens_hsa041151.14301009
34Inositol phosphate metabolism_Homo sapiens_hsa005621.06450873
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05185262
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03861801
37Acute myeloid leukemia_Homo sapiens_hsa052211.02398505
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00454396
39Oocyte meiosis_Homo sapiens_hsa041140.99514065
40FoxO signaling pathway_Homo sapiens_hsa040680.98760213
41Pancreatic cancer_Homo sapiens_hsa052120.97528589
42Viral carcinogenesis_Homo sapiens_hsa052030.95666108
43TGF-beta signaling pathway_Homo sapiens_hsa043500.94103934
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93628836
45Choline metabolism in cancer_Homo sapiens_hsa052310.93566558
46Glucagon signaling pathway_Homo sapiens_hsa049220.92958525
47Glioma_Homo sapiens_hsa052140.92483444
48Insulin signaling pathway_Homo sapiens_hsa049100.87312758
49Herpes simplex infection_Homo sapiens_hsa051680.86570024
50Small cell lung cancer_Homo sapiens_hsa052220.86537987
51AMPK signaling pathway_Homo sapiens_hsa041520.84402823
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83724385
53Estrogen signaling pathway_Homo sapiens_hsa049150.82432330
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81247521
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.79903348
56Bladder cancer_Homo sapiens_hsa052190.79613078
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.77970467
58Dorso-ventral axis formation_Homo sapiens_hsa043200.77451681
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.77347862
60Notch signaling pathway_Homo sapiens_hsa043300.76265223
61ABC transporters_Homo sapiens_hsa020100.76185923
62Prolactin signaling pathway_Homo sapiens_hsa049170.75372498
63Type II diabetes mellitus_Homo sapiens_hsa049300.73777949
64Hepatitis B_Homo sapiens_hsa051610.71889398
65B cell receptor signaling pathway_Homo sapiens_hsa046620.69921436
66Colorectal cancer_Homo sapiens_hsa052100.67926108
67Endometrial cancer_Homo sapiens_hsa052130.67639473
68HTLV-I infection_Homo sapiens_hsa051660.65996788
69Insulin resistance_Homo sapiens_hsa049310.63990734
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.63485967
71GnRH signaling pathway_Homo sapiens_hsa049120.59956840
72Purine metabolism_Homo sapiens_hsa002300.59253141
73Sulfur relay system_Homo sapiens_hsa041220.57448872
74Renal cell carcinoma_Homo sapiens_hsa052110.57236694
75Thyroid hormone synthesis_Homo sapiens_hsa049180.53193401
76Measles_Homo sapiens_hsa051620.52334788
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52078393
78Epstein-Barr virus infection_Homo sapiens_hsa051690.49729894
79VEGF signaling pathway_Homo sapiens_hsa043700.48393619
80Adherens junction_Homo sapiens_hsa045200.48049909
81N-Glycan biosynthesis_Homo sapiens_hsa005100.46018364
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45791000
83HIF-1 signaling pathway_Homo sapiens_hsa040660.42370569
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.41595418
85Pyrimidine metabolism_Homo sapiens_hsa002400.41335223
86Biosynthesis of amino acids_Homo sapiens_hsa012300.39969061
87RNA polymerase_Homo sapiens_hsa030200.38166367
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.37548198
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37396448
90Influenza A_Homo sapiens_hsa051640.37150896
91Hepatitis C_Homo sapiens_hsa051600.36548028
92Arginine biosynthesis_Homo sapiens_hsa002200.35524474
93Nitrogen metabolism_Homo sapiens_hsa009100.35021133
94Fatty acid biosynthesis_Homo sapiens_hsa000610.34991936
95Melanoma_Homo sapiens_hsa052180.33299253
96Wnt signaling pathway_Homo sapiens_hsa043100.33240248
97Hippo signaling pathway_Homo sapiens_hsa043900.32612789
98T cell receptor signaling pathway_Homo sapiens_hsa046600.32220015
99Propanoate metabolism_Homo sapiens_hsa006400.30842519
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28659284

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