KIAA0922

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.55575117
2regulation of B cell receptor signaling pathway (GO:0050855)6.36850592
3B cell receptor signaling pathway (GO:0050853)5.55478379
4negative thymic T cell selection (GO:0045060)4.98319722
5regulation of gamma-delta T cell activation (GO:0046643)4.97271187
6negative T cell selection (GO:0043383)4.96184191
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.89288320
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.87802823
9negative regulation of cell killing (GO:0031342)4.87802823
10regulation of gamma-delta T cell differentiation (GO:0045586)4.86263307
11positive thymic T cell selection (GO:0045059)4.40828715
12positive T cell selection (GO:0043368)4.39983683
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25870677
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.22613579
15positive regulation of granulocyte differentiation (GO:0030854)4.21803801
16T cell migration (GO:0072678)4.13197498
17positive regulation of B cell differentiation (GO:0045579)4.11377170
18T cell selection (GO:0045058)4.03891189
19positive regulation of humoral immune response (GO:0002922)4.02865078
20antigen processing and presentation of endogenous antigen (GO:0019883)4.02167763
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99184192
22response to interleukin-15 (GO:0070672)3.96063623
23regulation of B cell differentiation (GO:0045577)3.95398830
24thymic T cell selection (GO:0045061)3.93061787
25regulation of alpha-beta T cell proliferation (GO:0046640)3.86651868
26regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.83131060
27cellular response to interleukin-15 (GO:0071350)3.79676134
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.74680240
29histone H3-K36 demethylation (GO:0070544)3.72080683
30B cell homeostasis (GO:0001782)3.71152756
31B cell proliferation (GO:0042100)3.70033046
32negative regulation of T cell mediated immunity (GO:0002710)3.65974149
33positive regulation of alpha-beta T cell proliferation (GO:0046641)3.61149915
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59767423
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.59767423
36modulation by symbiont of host immune response (GO:0052553)3.59767423
37positive regulation by symbiont of host defense response (GO:0052509)3.59767423
38modulation by symbiont of host defense response (GO:0052031)3.59767423
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59767423
40immunoglobulin mediated immune response (GO:0016064)3.52269888
41CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.49159421
42tolerance induction (GO:0002507)3.47727025
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46756091
44antigen receptor-mediated signaling pathway (GO:0050851)3.45825417
45leukocyte aggregation (GO:0070486)3.44339774
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.30508616
47histone H3-K4 trimethylation (GO:0080182)3.28539498
48germinal center formation (GO:0002467)3.21271289
49B cell mediated immunity (GO:0019724)3.16586152
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.16454616
51T cell homeostasis (GO:0043029)3.13478340
52detection of bacterium (GO:0016045)3.11235124
53regulation of histone H3-K9 methylation (GO:0051570)3.10413050
54lymphocyte homeostasis (GO:0002260)3.09155291
55detection of other organism (GO:0098543)3.08815338
56response to muramyl dipeptide (GO:0032495)3.06478512
57positive regulation of interleukin-2 production (GO:0032743)3.04488461
58phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.01027930
59regulation of granulocyte differentiation (GO:0030852)2.95523651
60Peyers patch development (GO:0048541)2.93316009
61mucosal-associated lymphoid tissue development (GO:0048537)2.93316009
62negative regulation of histone methylation (GO:0031061)2.93281854
63macrophage activation involved in immune response (GO:0002281)2.90924078
64regulation of interferon-beta biosynthetic process (GO:0045357)2.87488028
65type I interferon signaling pathway (GO:0060337)2.85176323
66cellular response to type I interferon (GO:0071357)2.85176323
67T cell receptor signaling pathway (GO:0050852)2.84779807
68negative regulation of B cell proliferation (GO:0030889)2.84626496
69interferon-gamma production (GO:0032609)2.84356051
70regulation of B cell proliferation (GO:0030888)2.83332822
71response to type I interferon (GO:0034340)2.82523979
72mast cell activation (GO:0045576)2.82446138
73natural killer cell differentiation (GO:0001779)2.82216630
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80361019
75negative regulation of leukocyte mediated immunity (GO:0002704)2.78889592
76regulation of interleukin-2 biosynthetic process (GO:0045076)2.78818819
77positive regulation of B cell activation (GO:0050871)2.78619957
78positive regulation of interleukin-4 production (GO:0032753)2.78245837
79cellular extravasation (GO:0045123)2.78084335
80T cell lineage commitment (GO:0002360)2.77903096
81regulation of alpha-beta T cell activation (GO:0046634)2.74410228
82positive regulation of isotype switching (GO:0045830)2.73083571
83defense response to protozoan (GO:0042832)2.72356796
84activated T cell proliferation (GO:0050798)2.72025445
85response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66216049
86response to host immune response (GO:0052572)2.66216049
87T cell costimulation (GO:0031295)2.65722313
88neutrophil activation involved in immune response (GO:0002283)2.64939988
89histone H3-K9 modification (GO:0061647)2.64193114
90positive regulation of B cell mediated immunity (GO:0002714)2.63793835
91positive regulation of immunoglobulin mediated immune response (GO:0002891)2.63793835
92regulation of B cell activation (GO:0050864)2.63718562
93leukocyte homeostasis (GO:0001776)2.63304038
94lymphocyte proliferation (GO:0046651)2.62994950
95peptidyl-lysine trimethylation (GO:0018023)2.62929400
96interferon-gamma-mediated signaling pathway (GO:0060333)2.62529296
97lymphocyte costimulation (GO:0031294)2.62490577
98positive regulation of B cell proliferation (GO:0030890)2.62292072
99regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60396120
100negative regulation of phagocytosis (GO:0050765)2.60156807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.30261441
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.17047083
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.81633728
4* MYC_22102868_ChIP-Seq_BL_Human3.77372719
5E2F7_22180533_ChIP-Seq_HELA_Human3.55484588
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47236044
7RUNX_20019798_ChIP-Seq_JUKART_Human3.35790493
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23417434
9* MYB_26560356_Chip-Seq_TH2_Human3.19557159
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.04439582
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.85182236
12MYB_26560356_Chip-Seq_TH1_Human2.81657307
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.75643277
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67273178
15CIITA_25753668_ChIP-Seq_RAJI_Human2.67202912
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.65284138
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59304057
18* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.55057514
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.50987938
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48456545
21SCL_19346495_ChIP-Seq_HPC-7_Human2.37407777
22MAF_26560356_Chip-Seq_TH1_Human2.37174071
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30558443
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29335307
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24700005
26* SPI1_23547873_ChIP-Seq_NB4_Human2.21164626
27* GATA3_27048872_Chip-Seq_THYMUS_Human2.17593066
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.17517790
29UTX_26944678_Chip-Seq_JUKART_Human2.17173026
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06694961
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04584140
32VDR_21846776_ChIP-Seq_THP-1_Human2.01362759
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01251315
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99327976
35GATA1_22025678_ChIP-Seq_K562_Human1.96308463
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93126657
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89105853
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79139416
39MAF_26560356_Chip-Seq_TH2_Human1.67638633
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.66801699
41GATA3_26560356_Chip-Seq_TH2_Human1.65678034
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65569543
43* VDR_24763502_ChIP-Seq_THP-1_Human1.63940299
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63285051
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62034369
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.61562911
47EZH2_22144423_ChIP-Seq_EOC_Human1.60144036
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.59316391
49* SPI1_23127762_ChIP-Seq_K562_Human1.58730150
50RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58360542
51TCF7_22412390_ChIP-Seq_EML_Mouse1.55162661
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54713042
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.51956682
54VDR_23849224_ChIP-Seq_CD4+_Human1.45130043
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.44727134
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43934957
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41717468
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41009013
59FOXP3_21729870_ChIP-Seq_TREG_Human1.39749002
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37667966
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30655740
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30534855
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27468907
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23533080
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.22178107
66PU_27001747_Chip-Seq_BMDM_Mouse1.21071176
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19163415
68VDR_24787735_ChIP-Seq_THP-1_Human1.16246823
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15511974
70* SMRT_27268052_Chip-Seq_Bcells_Human1.03084196
71GATA3_26560356_Chip-Seq_TH1_Human1.02651402
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02548330
73IRF1_19129219_ChIP-ChIP_H3396_Human1.02298746
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01985506
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00798460
76* KDM2B_26808549_Chip-Seq_DND41_Human0.98690530
77ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97365881
78* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94051946
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93124702
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92508215
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88938703
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88554783
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88442331
84PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86653612
85TFEB_21752829_ChIP-Seq_HELA_Human0.86328591
86* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85650989
87ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83179159
88RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82253543
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81927691
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81841496
91GATA1_19941826_ChIP-Seq_K562_Human0.81418533
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.80848162
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.80583850
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79880006
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78791207
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75907543
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74325187
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.73802555
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.73506667
100KDM5A_27292631_Chip-Seq_BREAST_Human0.72615004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.17417572
2MP0001835_abnormal_antigen_presentation3.73501283
3MP0000685_abnormal_immune_system3.63024054
4MP0001800_abnormal_humoral_immune3.60374550
5MP0008057_abnormal_DNA_replication3.49477142
6MP0005671_abnormal_response_to3.40445414
7MP0005000_abnormal_immune_tolerance2.96744646
8MP0001790_abnormal_immune_system2.95625776
9MP0005387_immune_system_phenotype2.95625776
10MP0003436_decreased_susceptibility_to2.88118760
11MP0002398_abnormal_bone_marrow2.70747698
12MP0002420_abnormal_adaptive_immunity2.68454616
13MP0002723_abnormal_immune_serum2.67383761
14MP0002452_abnormal_antigen_presenting2.65315815
15MP0001819_abnormal_immune_cell2.61675596
16MP0003724_increased_susceptibility_to2.47870181
17MP0000703_abnormal_thymus_morphology2.35064839
18MP0002166_altered_tumor_susceptibility2.33906413
19MP0003303_peritoneal_inflammation2.33582155
20MP0000716_abnormal_immune_system2.31791888
21MP0002396_abnormal_hematopoietic_system2.30545742
22MP0000689_abnormal_spleen_morphology2.28348963
23MP0004381_abnormal_hair_follicle2.20703234
24MP0002722_abnormal_immune_system2.17576663
25MP0002009_preneoplasia2.12225622
26MP0005025_abnormal_response_to2.11775725
27MP0002419_abnormal_innate_immunity2.02282877
28MP0009785_altered_susceptibility_to1.93048129
29MP0002429_abnormal_blood_cell1.89729444
30MP0005075_abnormal_melanosome_morpholog1.88112448
31MP0002138_abnormal_hepatobiliary_system1.87759111
32MP0009333_abnormal_splenocyte_physiolog1.79711549
33MP0002405_respiratory_system_inflammati1.79027589
34MP0005310_abnormal_salivary_gland1.70984243
35MP0002006_tumorigenesis1.59794008
36MP0002148_abnormal_hypersensitivity_rea1.59244573
37MP0008260_abnormal_autophagy1.55302289
38MP0000465_gastrointestinal_hemorrhage1.52549133
39MP0010094_abnormal_chromosome_stability1.51631119
40MP0001873_stomach_inflammation1.49372735
41MP0010155_abnormal_intestine_physiology1.49169196
42MP0004947_skin_inflammation1.47294960
43MP0003300_gastrointestinal_ulcer1.44328010
44MP0005464_abnormal_platelet_physiology1.43821563
45MP0008877_abnormal_DNA_methylation1.43766812
46MP0005451_abnormal_body_composition1.42666825
47MP0001845_abnormal_inflammatory_respons1.40720516
48MP0003656_abnormal_erythrocyte_physiolo1.38087039
49MP0003866_abnormal_defecation1.29248842
50MP0004808_abnormal_hematopoietic_stem1.23580980
51MP0003221_abnormal_cardiomyocyte_apopto1.23379577
52MP0008995_early_reproductive_senescence1.20984929
53MP0002019_abnormal_tumor_incidence1.20407057
54MP0000372_irregular_coat_pigmentation1.18682342
55MP0003077_abnormal_cell_cycle1.18221951
56MP0003183_abnormal_peptide_metabolism1.14930490
57MP0003111_abnormal_nucleus_morphology1.14696129
58MP0005645_abnormal_hypothalamus_physiol1.10244004
59MP0001986_abnormal_taste_sensitivity1.07131301
60MP0008058_abnormal_DNA_repair1.06062013
61MP0009278_abnormal_bone_marrow0.93610872
62MP0005397_hematopoietic_system_phenotyp0.92954556
63MP0001545_abnormal_hematopoietic_system0.92954556
64MP0000015_abnormal_ear_pigmentation0.90479937
65MP0001853_heart_inflammation0.90325911
66MP0003786_premature_aging0.86782469
67MP0008469_abnormal_protein_level0.85699772
68MP0001533_abnormal_skeleton_physiology0.82468716
69MP0003693_abnormal_embryo_hatching0.81445866
70MP0008961_abnormal_basal_metabolism0.80592320
71MP0000313_abnormal_cell_death0.76338643
72MP0003828_pulmonary_edema0.75997839
73MP0001851_eye_inflammation0.74512016
74MP0000350_abnormal_cell_proliferation0.71791102
75MP0005076_abnormal_cell_differentiation0.70975560
76MP0003045_fibrosis0.70668663
77MP0002163_abnormal_gland_morphology0.69904825
78MP0000569_abnormal_digit_pigmentation0.69713420
79MP0003787_abnormal_imprinting0.69108351
80MP0002132_abnormal_respiratory_system0.69084782
81MP0000490_abnormal_crypts_of0.69066093
82MP0003646_muscle_fatigue0.67182766
83MP0009763_increased_sensitivity_to0.66908502
84MP0009764_decreased_sensitivity_to0.65787428
85MP0002933_joint_inflammation0.65556103
86MP0005621_abnormal_cell_physiology0.65528600
87MP0000858_altered_metastatic_potential0.64338328
88MP0002928_abnormal_bile_duct0.62154426
89MP0004130_abnormal_muscle_cell0.60980257
90MP0005266_abnormal_metabolism0.56227003
91MP0006082_CNS_inflammation0.55753986
92MP0001730_embryonic_growth_arrest0.54716006
93MP0009115_abnormal_fat_cell0.54082201
94MP0003091_abnormal_cell_migration0.53759916
95MP0002332_abnormal_exercise_endurance0.53720476
96MP0003252_abnormal_bile_duct0.52730388
97MP0003718_maternal_effect0.52061021
98MP0004883_abnormal_blood_vessel0.48617507
99MP0009765_abnormal_xenobiotic_induced0.47952290
100MP0000609_abnormal_liver_physiology0.47831498

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)5.07525086
2Agammaglobulinemia (HP:0004432)4.98145218
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.57245938
4Gastrointestinal stroma tumor (HP:0100723)4.54289461
5T lymphocytopenia (HP:0005403)4.41391784
6Meningitis (HP:0001287)4.32875721
7IgM deficiency (HP:0002850)4.28085300
8Recurrent viral infections (HP:0004429)4.26704430
9Lymphopenia (HP:0001888)4.22466221
10Abnormality of T cell number (HP:0011839)4.18400472
11Recurrent fungal infections (HP:0002841)4.09790873
12Eczematoid dermatitis (HP:0000976)3.99235779
13Abnormality of cells of the lymphoid lineage (HP:0012140)3.91586985
14IgG deficiency (HP:0004315)3.87649291
15Mediastinal lymphadenopathy (HP:0100721)3.78626799
16Colitis (HP:0002583)3.77898259
17Recurrent bacterial skin infections (HP:0005406)3.75064552
18Abnormality of T cells (HP:0002843)3.74360915
19Severe combined immunodeficiency (HP:0004430)3.73587158
20Vasculitis (HP:0002633)3.73384318
21IgA deficiency (HP:0002720)3.71373036
22Recurrent cutaneous fungal infections (HP:0011370)3.68742132
23Chronic mucocutaneous candidiasis (HP:0002728)3.68742132
24Recurrent bronchitis (HP:0002837)3.55499155
25Recurrent sinusitis (HP:0011108)3.45429649
26Recurrent abscess formation (HP:0002722)3.44670613
27Inflammation of the large intestine (HP:0002037)3.44098047
28Encephalitis (HP:0002383)3.39218053
29Gastrointestinal inflammation (HP:0004386)3.36946780
30Gastrointestinal infarctions (HP:0005244)3.34925493
31Autoimmune hemolytic anemia (HP:0001890)3.30716117
32Combined immunodeficiency (HP:0005387)3.28886028
33Abnormality of B cell number (HP:0010975)3.26811565
34Papilloma (HP:0012740)3.24447578
35Verrucae (HP:0200043)3.24447578
36Lymphoma (HP:0002665)3.20206876
37B lymphocytopenia (HP:0010976)3.19192492
38Abnormality of T cell physiology (HP:0011840)3.18482770
39Cellulitis (HP:0100658)3.12349758
40Stomatitis (HP:0010280)3.00774212
41Spontaneous hematomas (HP:0007420)2.99061869
42Osteomyelitis (HP:0002754)2.93220866
43Granulocytopenia (HP:0001913)2.90459491
44Retrobulbar optic neuritis (HP:0100654)2.89932986
45Optic neuritis (HP:0100653)2.89932986
46Viral hepatitis (HP:0006562)2.87133656
47Recurrent skin infections (HP:0001581)2.86211427
48Basal cell carcinoma (HP:0002671)2.83979943
49Chronic diarrhea (HP:0002028)2.81012103
50Chest pain (HP:0100749)2.77807718
51Eosinophilia (HP:0001880)2.76166231
52Abnormality of the fingertips (HP:0001211)2.74708663
53Abnormality of eosinophils (HP:0001879)2.73539080
54Increased IgM level (HP:0003496)2.70695755
55Myositis (HP:0100614)2.70505839
56Abnormality of the prostate (HP:0008775)2.67584829
57Leukocytosis (HP:0001974)2.62635516
58Hypoplasia of the thymus (HP:0000778)2.59820329
59Thyroiditis (HP:0100646)2.58789625
60Abnormality of macrophages (HP:0004311)2.54923533
61Pustule (HP:0200039)2.54119666
62Orchitis (HP:0100796)2.45962801
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.45509194
64Pulmonary infiltrates (HP:0002113)2.41722559
65Increased IgE level (HP:0003212)2.39961638
66Elevated erythrocyte sedimentation rate (HP:0003565)2.37921416
67Obstructive lung disease (HP:0006536)2.36927512
68Chronic obstructive pulmonary disease (HP:0006510)2.36927512
69Hypochromic microcytic anemia (HP:0004840)2.36572850
70Sepsis (HP:0100806)2.35934037
71Keratoconjunctivitis sicca (HP:0001097)2.35416530
72Prolonged bleeding time (HP:0003010)2.35059980
73Emphysema (HP:0002097)2.31267557
74Restrictive lung disease (HP:0002091)2.28685675
75Fatigue (HP:0012378)2.27925512
76Hypochromic anemia (HP:0001931)2.27152591
77Recurrent gram-negative bacterial infections (HP:0005420)2.26623888
78Urticaria (HP:0001025)2.24888203
79Stomach cancer (HP:0012126)2.23347553
80Acute hepatic failure (HP:0006554)2.23237416
81Keratoconjunctivitis (HP:0001096)2.22388783
82Recurrent lower respiratory tract infections (HP:0002783)2.19805574
83Leukopenia (HP:0001882)2.15586421
84Recurrent pneumonia (HP:0006532)2.14798454
85Aplasia/Hypoplasia of the thymus (HP:0010515)2.14178600
86Amaurosis fugax (HP:0100576)2.12765617
87Epistaxis (HP:0000421)2.12565368
88Hemoptysis (HP:0002105)2.10204388
89Prostate neoplasm (HP:0100787)2.08890108
90Gingival bleeding (HP:0000225)2.08168323
91Arterial thrombosis (HP:0004420)2.05762472
92Hepatitis (HP:0012115)1.94997846
93Microcytic anemia (HP:0001935)1.90926917
94Abnormality of male internal genitalia (HP:0000022)1.90276753
95Abnormality of the peritoneum (HP:0002585)1.90193202
96Slow saccadic eye movements (HP:0000514)1.87533569
97Chronic otitis media (HP:0000389)1.86596904
98Gingivitis (HP:0000230)1.86142956
99Bronchitis (HP:0012387)1.85987233
100Autoimmune thrombocytopenia (HP:0001973)1.85555223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.60590251
2RIPK43.85842079
3PRPF4B3.12470784
4MAP3K103.09961464
5TAOK32.64737222
6MAP3K142.50109368
7SYK2.28354313
8CDK122.25871428
9BTK2.23296081
10TXK2.16709812
11BLK2.10492339
12IRAK42.07059127
13SIK32.05158002
14GRK62.01361794
15MAP3K132.00266478
16TYK21.89837122
17SIK21.83176165
18IKBKE1.81128772
19FES1.73241208
20TEC1.62464121
21JAK31.57530196
22ITK1.47875173
23BRD41.47794700
24CSF1R1.45849079
25JAK11.45006750
26LYN1.43475610
27HCK1.39896024
28TNK21.32932635
29CSK1.32866773
30ERN11.25518222
31CDK41.25230747
32NLK1.24596459
33PIM11.19870733
34MARK31.19497401
35IKBKB1.18939972
36LCK1.18037240
37PIK3CG1.14192304
38MAPK111.11031072
39MAP2K31.09557056
40PASK1.08949569
41ZAP701.02818159
42EIF2AK31.01395853
43BMPR20.97015941
44FGR0.96790486
45PRKCQ0.96758084
46JAK20.95826045
47SMG10.90435917
48STK100.86808832
49MELK0.86653201
50TBK10.85861289
51KIT0.82395389
52CDK190.82093358
53FGFR30.75706194
54CHUK0.74522183
55IRAK10.73133585
56FGFR40.72413995
57NEK90.69130379
58MAPK120.67418941
59PDK10.66952044
60MAPK70.64994056
61KSR20.63888867
62MAP3K70.63289107
63SGK20.63280275
64YES10.62258276
65MARK20.57142165
66TESK20.55522480
67EEF2K0.55307382
68CDC42BPA0.53364245
69STK240.53259203
70IRAK20.52445351
71EPHA30.52042745
72TRIM280.49907756
73CDK90.49605685
74ATR0.49419750
75RAF10.47138177
76TAOK10.45022438
77MAPK40.44998851
78MAP3K50.44964264
79RPS6KA40.44867526
80MAP2K20.44390340
81CDC70.44361845
82CDK60.43265193
83SGK30.40926507
84CAMKK20.40838483
85SRPK10.39724004
86CHEK10.39514096
87STK40.39477622
88HIPK20.38391619
89CAMK40.36506861
90ZAK0.36085324
91OBSCN0.35766240
92RPS6KB20.35084807
93WNK10.33272254
94MAPK130.31688769
95CAMKK10.31339088
96EGFR0.29237368
97PRKCH0.28597045
98MATK0.28474666
99MST40.28324988
100MAPKAPK20.27119887

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.50579456
2B cell receptor signaling pathway_Homo sapiens_hsa046623.35580057
3Allograft rejection_Homo sapiens_hsa053302.92072306
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.81916814
5Autoimmune thyroid disease_Homo sapiens_hsa053202.76950243
6Graft-versus-host disease_Homo sapiens_hsa053322.70537763
7T cell receptor signaling pathway_Homo sapiens_hsa046602.33202982
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.23072157
9Leishmaniasis_Homo sapiens_hsa051402.17849569
10Type I diabetes mellitus_Homo sapiens_hsa049402.07518302
11Asthma_Homo sapiens_hsa053102.05703082
12Herpes simplex infection_Homo sapiens_hsa051682.01988554
13Measles_Homo sapiens_hsa051622.01701626
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99226291
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99058727
16Viral myocarditis_Homo sapiens_hsa054161.90551145
17Osteoclast differentiation_Homo sapiens_hsa043801.85941949
18Hematopoietic cell lineage_Homo sapiens_hsa046401.84602298
19Influenza A_Homo sapiens_hsa051641.66603788
20Antigen processing and presentation_Homo sapiens_hsa046121.65842518
21Acute myeloid leukemia_Homo sapiens_hsa052211.64407494
22Non-small cell lung cancer_Homo sapiens_hsa052231.57490203
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52526308
24Hepatitis B_Homo sapiens_hsa051611.52316512
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48042347
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47828669
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47681587
28Staphylococcus aureus infection_Homo sapiens_hsa051501.46609639
29Epstein-Barr virus infection_Homo sapiens_hsa051691.43084390
30Toxoplasmosis_Homo sapiens_hsa051451.39728303
31Tuberculosis_Homo sapiens_hsa051521.37780368
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.35785909
33Viral carcinogenesis_Homo sapiens_hsa052031.34302757
34Systemic lupus erythematosus_Homo sapiens_hsa053221.29826831
35Chemokine signaling pathway_Homo sapiens_hsa040621.22517176
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16277240
37Apoptosis_Homo sapiens_hsa042101.15690245
38Pancreatic cancer_Homo sapiens_hsa052121.12443076
39Colorectal cancer_Homo sapiens_hsa052101.07449659
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06383335
41Chronic myeloid leukemia_Homo sapiens_hsa052201.05437286
42TNF signaling pathway_Homo sapiens_hsa046681.04750639
43Non-homologous end-joining_Homo sapiens_hsa034500.99589300
44HTLV-I infection_Homo sapiens_hsa051660.99394720
45Cell cycle_Homo sapiens_hsa041100.89229368
46Prostate cancer_Homo sapiens_hsa052150.87841821
47Hepatitis C_Homo sapiens_hsa051600.86958458
48FoxO signaling pathway_Homo sapiens_hsa040680.84665703
49Platelet activation_Homo sapiens_hsa046110.83931543
50Endometrial cancer_Homo sapiens_hsa052130.83723845
51Inositol phosphate metabolism_Homo sapiens_hsa005620.83292576
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.81864011
53Base excision repair_Homo sapiens_hsa034100.80040602
54mTOR signaling pathway_Homo sapiens_hsa041500.79114288
55Prolactin signaling pathway_Homo sapiens_hsa049170.78203087
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78074709
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77997761
58Shigellosis_Homo sapiens_hsa051310.77611066
59mRNA surveillance pathway_Homo sapiens_hsa030150.74973497
60Renal cell carcinoma_Homo sapiens_hsa052110.74183750
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69327579
62Dorso-ventral axis formation_Homo sapiens_hsa043200.68587028
63Malaria_Homo sapiens_hsa051440.66778979
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66198691
65Legionellosis_Homo sapiens_hsa051340.63436068
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.62608213
67Fanconi anemia pathway_Homo sapiens_hsa034600.58102398
68Small cell lung cancer_Homo sapiens_hsa052220.57941396
69RNA degradation_Homo sapiens_hsa030180.57516809
70Choline metabolism in cancer_Homo sapiens_hsa052310.57240194
71p53 signaling pathway_Homo sapiens_hsa041150.56158421
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55052635
73Spliceosome_Homo sapiens_hsa030400.54953542
74DNA replication_Homo sapiens_hsa030300.54632910
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54232519
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53661595
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.51843469
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51299963
79Basal transcription factors_Homo sapiens_hsa030220.49736308
80Thyroid cancer_Homo sapiens_hsa052160.48691266
81Glioma_Homo sapiens_hsa052140.47677694
82Alcoholism_Homo sapiens_hsa050340.47547436
83VEGF signaling pathway_Homo sapiens_hsa043700.47445355
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47339504
85HIF-1 signaling pathway_Homo sapiens_hsa040660.44044619
86ErbB signaling pathway_Homo sapiens_hsa040120.43543471
87Mismatch repair_Homo sapiens_hsa034300.42820998
88Insulin resistance_Homo sapiens_hsa049310.42654132
89Rheumatoid arthritis_Homo sapiens_hsa053230.41552184
90Phagosome_Homo sapiens_hsa041450.41359735
91MicroRNAs in cancer_Homo sapiens_hsa052060.40427244
92Notch signaling pathway_Homo sapiens_hsa043300.39533652
93African trypanosomiasis_Homo sapiens_hsa051430.39462510
94Homologous recombination_Homo sapiens_hsa034400.38781689
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38472099
96Type II diabetes mellitus_Homo sapiens_hsa049300.38394600
97MAPK signaling pathway_Homo sapiens_hsa040100.33832606
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33605667
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31911404
100RNA transport_Homo sapiens_hsa030130.31602255

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