KIAA0930

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)4.52422065
2response to peptidoglycan (GO:0032494)4.28400475
3cellular response to thyroid hormone stimulus (GO:0097067)4.03400585
4glycolipid catabolic process (GO:0019377)4.03231286
5amino sugar catabolic process (GO:0046348)3.99567284
6neutrophil activation involved in immune response (GO:0002283)3.92690193
7oligosaccharide catabolic process (GO:0009313)3.90069458
8regulation of leukocyte degranulation (GO:0043300)3.88170772
9negative regulation of erythrocyte differentiation (GO:0045647)3.85222532
10negative regulation of interleukin-12 production (GO:0032695)3.83568855
11mannose metabolic process (GO:0006013)3.80621471
12macrophage activation involved in immune response (GO:0002281)3.77754686
13regulation of myeloid leukocyte mediated immunity (GO:0002886)3.68163444
14positive regulation of mast cell degranulation (GO:0043306)3.64007229
15positive regulation of mast cell activation involved in immune response (GO:0033008)3.64007229
16positive regulation of mast cell activation (GO:0033005)3.63674123
17protein localization to endosome (GO:0036010)3.60609684
18regulation of mast cell degranulation (GO:0043304)3.59911462
19regulation of regulated secretory pathway (GO:1903305)3.54556589
20barbed-end actin filament capping (GO:0051016)3.53633132
21positive regulation of leukocyte degranulation (GO:0043302)3.51466805
22ceramide catabolic process (GO:0046514)3.50855177
23positive regulation by symbiont of host defense response (GO:0052509)3.36631639
24modulation by symbiont of host defense response (GO:0052031)3.36631639
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36631639
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36631639
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.36631639
28modulation by symbiont of host immune response (GO:0052553)3.36631639
29positive regulation of cellular amide metabolic process (GO:0034250)3.22888953
30regulation of mast cell activation involved in immune response (GO:0033006)3.21752282
31response to thyroid hormone (GO:0097066)3.17971632
32regulation of cholesterol storage (GO:0010885)3.15835349
33positive regulation of gamma-delta T cell activation (GO:0046645)3.14730926
34L-amino acid import (GO:0043092)3.13333252
35positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.09784873
36adenosine receptor signaling pathway (GO:0001973)3.06150888
37cellular extravasation (GO:0045123)3.02803184
38positive regulation of regulated secretory pathway (GO:1903307)3.02376782
39positive regulation of monocyte chemotaxis (GO:0090026)3.02324274
40negative regulation of cell killing (GO:0031342)2.98867578
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.98867578
42N-acetylneuraminate metabolic process (GO:0006054)2.95278402
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93856622
44synaptic vesicle exocytosis (GO:0016079)2.92787304
45response to muramyl dipeptide (GO:0032495)2.87046914
46negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86938084
47regulation of mast cell activation (GO:0033003)2.85959533
48detection of molecule of bacterial origin (GO:0032490)2.85180976
49detection of other organism (GO:0098543)2.83463776
50regulation of superoxide anion generation (GO:0032928)2.83386558
51phagosome maturation (GO:0090382)2.83166296
52lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80121603
53immunoglobulin mediated immune response (GO:0016064)2.75069527
54regulation of ARF protein signal transduction (GO:0032012)2.74285868
55membrane lipid catabolic process (GO:0046466)2.73503181
56regulation of early endosome to late endosome transport (GO:2000641)2.73117198
57myeloid cell activation involved in immune response (GO:0002275)2.72175295
58sphingolipid catabolic process (GO:0030149)2.71379757
59ganglioside metabolic process (GO:0001573)2.69784211
60response to acidic pH (GO:0010447)2.67151114
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66308429
62regulation of macrophage chemotaxis (GO:0010758)2.66096849
63detection of external biotic stimulus (GO:0098581)2.64117553
64positive regulation of macrophage cytokine production (GO:0060907)2.63627805
65synaptic vesicle maturation (GO:0016188)2.62015010
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.61942508
67macrophage activation (GO:0042116)2.61937530
68amino acid import (GO:0043090)2.61906886
69apoptotic cell clearance (GO:0043277)2.60924311
70synaptic vesicle docking involved in exocytosis (GO:0016081)2.60384976
71regulation of monocyte chemotaxis (GO:0090025)2.60022011
72G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.58379490
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56603548
74detection of bacterium (GO:0016045)2.55608569
75neuromuscular process controlling balance (GO:0050885)2.55324898
76regulation of macrophage cytokine production (GO:0010935)2.53506903
77epithelial cell differentiation involved in prostate gland development (GO:0060742)2.53297942
78granulocyte activation (GO:0036230)2.52578578
79pinocytosis (GO:0006907)2.49772570
80regulation of T-helper 2 cell differentiation (GO:0045628)2.47695438
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.47625862
82lytic vacuole organization (GO:0080171)2.47547898
83lysosome organization (GO:0007040)2.47547898
84positive regulation of protein dephosphorylation (GO:0035307)2.47129833
85cortical actin cytoskeleton organization (GO:0030866)2.47039168
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.47027863
87regulation of mononuclear cell migration (GO:0071675)2.46631465
88negative regulation of interleukin-17 production (GO:0032700)2.38509174
89adhesion of symbiont to host cell (GO:0044650)2.38109111
90virion attachment to host cell (GO:0019062)2.38109111
91positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.37700039
92respiratory burst (GO:0045730)2.37554748
93myeloid dendritic cell differentiation (GO:0043011)2.36949431
94G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.35697977
95detection of biotic stimulus (GO:0009595)2.34344387
96positive regulation of antigen processing and presentation (GO:0002579)2.33807129
97macrophage differentiation (GO:0030225)2.32611091
98negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31325593
99positive regulation of Rap GTPase activity (GO:0032854)2.30796520
100interferon-gamma-mediated signaling pathway (GO:0060333)2.29806358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.19995097
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.18708875
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.95970103
4LXR_22292898_ChIP-Seq_THP-1_Human2.87361337
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69090539
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.48600386
7VDR_24763502_ChIP-Seq_THP-1_Human2.47034644
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.41658501
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39051883
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.33666985
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.22458952
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18682494
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14794965
14KDM2B_26808549_Chip-Seq_K562_Human2.08484743
15KDM2B_26808549_Chip-Seq_DND41_Human2.04481296
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.02803980
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96722533
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96265128
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94546896
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89671809
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.86630542
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84576239
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75716705
24TCF7_22412390_ChIP-Seq_EML_Mouse1.75441183
25MYC_22102868_ChIP-Seq_BL_Human1.73164265
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71366875
27SPI1_23127762_ChIP-Seq_K562_Human1.69795442
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68785860
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68535488
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.68459055
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66765987
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66311552
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64994855
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63219480
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60599786
36DROSHA_22980978_ChIP-Seq_HELA_Human1.60067829
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56337330
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.56103890
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54120509
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.52475468
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51588541
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.49695783
43SCL_19346495_ChIP-Seq_HPC-7_Human1.48413604
44VDR_24787735_ChIP-Seq_THP-1_Human1.48377613
45RACK7_27058665_Chip-Seq_MCF-7_Human1.42647730
46P68_20966046_ChIP-Seq_HELA_Human1.41399404
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40411586
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.40105058
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39303160
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35451730
51SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35426742
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33706749
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32022000
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31327660
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30883592
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30755992
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29982993
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.29944317
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.29191755
60SMC4_20622854_ChIP-Seq_HELA_Human1.29082227
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26707844
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24869962
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24158591
64BCOR_27268052_Chip-Seq_Bcells_Human1.23597514
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23528367
66MAF_26560356_Chip-Seq_TH1_Human1.23158063
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20525245
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20490312
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17891252
70BCL6_27268052_Chip-Seq_Bcells_Human1.17772555
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.17557066
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16251599
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14056461
74SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12809691
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11947863
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.11724754
77SPI1_23547873_ChIP-Seq_NB4_Human1.11648427
78MAF_26560356_Chip-Seq_TH2_Human1.10576390
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09776539
80UTX_26944678_Chip-Seq_JUKART_Human1.09347280
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07749340
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06862993
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06620088
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05887676
85GATA1_19941826_ChIP-Seq_K562_Human1.03768060
86CTCF_27219007_Chip-Seq_Bcells_Human1.03745745
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03263552
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02364756
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01525390
90SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01291048
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00867871
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99594923
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99485968
94OCT4_19829295_ChIP-Seq_ESCs_Human0.98347628
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97891701
96CREB1_26743006_Chip-Seq_LNCaP_Human0.97528333
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96557001
98EZH2_22144423_ChIP-Seq_EOC_Human0.96250130
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94652229
100SA1_27219007_Chip-Seq_Bcells_Human0.94293050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.05498108
2MP0003172_abnormal_lysosome_physiology4.27984585
3MP0000604_amyloidosis3.33953736
4MP0003303_peritoneal_inflammation3.19482034
5MP0003329_amyloid_beta_deposits3.12150760
6MP0009840_abnormal_foam_cell3.04680788
7MP0003690_abnormal_glial_cell2.99201298
8MP0006082_CNS_inflammation2.99041198
9MP0003436_decreased_susceptibility_to2.70006284
10MP0002419_abnormal_innate_immunity2.53235748
11MP0003191_abnormal_cellular_cholesterol2.43404664
12MP0004859_abnormal_synaptic_plasticity2.43178250
13MP0003075_altered_response_to2.33475465
14MP0000920_abnormal_myelination2.15294579
15MP0002148_abnormal_hypersensitivity_rea2.09932965
16MP0001835_abnormal_antigen_presentation2.06176010
17MP0005025_abnormal_response_to1.96002852
18MP0000343_altered_response_to1.92892896
19MP0009278_abnormal_bone_marrow1.89304010
20MP0003300_gastrointestinal_ulcer1.88844381
21MP0005671_abnormal_response_to1.84199697
22MP0002998_abnormal_bone_remodeling1.83809597
23MP0008260_abnormal_autophagy1.82758085
24MP0003724_increased_susceptibility_to1.79247410
25MP0005000_abnormal_immune_tolerance1.75464162
26MP0000685_abnormal_immune_system1.75099333
27MP0003879_abnormal_hair_cell1.70425369
28MP0001790_abnormal_immune_system1.67169042
29MP0005387_immune_system_phenotype1.67169042
30MP0002064_seizures1.63470242
31MP0001533_abnormal_skeleton_physiology1.61258831
32MP0009785_altered_susceptibility_to1.60165985
33MP0005451_abnormal_body_composition1.59697043
34MP0003634_abnormal_glial_cell1.58251972
35MP0002452_abnormal_antigen_presenting1.57634385
36MP0000015_abnormal_ear_pigmentation1.56859317
37MP0004510_myositis1.55216346
38MP0005464_abnormal_platelet_physiology1.54074306
39MP0003705_abnormal_hypodermis_morpholog1.48318124
40MP0004947_skin_inflammation1.46795065
41MP0002723_abnormal_immune_serum1.42887509
42MP0002420_abnormal_adaptive_immunity1.37540047
43MP0001819_abnormal_immune_cell1.36395642
44MP0003453_abnormal_keratinocyte_physiol1.35482475
45MP0005409_darkened_coat_color1.33449826
46MP0005167_abnormal_blood-brain_barrier1.31326221
47MP0004270_analgesia1.30771534
48MP0005166_decreased_susceptibility_to1.30362128
49MP0003633_abnormal_nervous_system1.26376864
50MP0001800_abnormal_humoral_immune1.25660525
51MP0003632_abnormal_nervous_system1.23289380
52MP0001849_ear_inflammation1.23112222
53MP0005310_abnormal_salivary_gland1.22940865
54MP0001853_heart_inflammation1.22729692
55MP0004381_abnormal_hair_follicle1.21056576
56MP0003635_abnormal_synaptic_transmissio1.19159516
57MP0003828_pulmonary_edema1.16607135
58MP0001545_abnormal_hematopoietic_system1.14860650
59MP0005397_hematopoietic_system_phenotyp1.14860650
60MP0005257_abnormal_intraocular_pressure1.12940197
61MP0003631_nervous_system_phenotype1.11791110
62MP0003183_abnormal_peptide_metabolism1.11218898
63MP0000858_altered_metastatic_potential1.09313824
64MP0001845_abnormal_inflammatory_respons1.08834002
65MP0002877_abnormal_melanocyte_morpholog1.08002177
66MP0004130_abnormal_muscle_cell1.07408448
67MP0000371_diluted_coat_color1.03953891
68MP0003448_altered_tumor_morphology1.03633858
69MP0002063_abnormal_learning/memory/cond1.03602769
70MP0008569_lethality_at_weaning1.03129767
71MP0009764_decreased_sensitivity_to1.00400107
72MP0002405_respiratory_system_inflammati0.96536213
73MP0008874_decreased_physiological_sensi0.96010305
74MP0002139_abnormal_hepatobiliary_system0.94444597
75MP0008469_abnormal_protein_level0.94080938
76MP0009333_abnormal_splenocyte_physiolog0.86225339
77MP0002229_neurodegeneration0.86106665
78MP0000716_abnormal_immune_system0.84331605
79MP0003091_abnormal_cell_migration0.82357358
80MP0005423_abnormal_somatic_nervous0.81626253
81MP0000569_abnormal_digit_pigmentation0.80343743
82MP0003880_abnormal_central_pattern0.79274462
83MP0001440_abnormal_grooming_behavior0.78936916
84MP0010155_abnormal_intestine_physiology0.77244936
85MP0001958_emphysema0.77114895
86MP0003279_aneurysm0.76274292
87MP0005174_abnormal_tail_pigmentation0.75681616
88MP0000747_muscle_weakness0.75145242
89MP0004858_abnormal_nervous_system0.74546316
90MP0009745_abnormal_behavioral_response0.74267155
91MP0002090_abnormal_vision0.73868234
92MP0004742_abnormal_vestibular_system0.72878469
93MP0009046_muscle_twitch0.71998795
94MP0004185_abnormal_adipocyte_glucose0.71587303
95MP0001851_eye_inflammation0.71129247
96MP0005390_skeleton_phenotype0.68858446
97MP0001970_abnormal_pain_threshold0.67081459
98MP0002734_abnormal_mechanical_nocicepti0.65907480
99MP0000681_abnormal_thyroid_gland0.63437530
100MP0002572_abnormal_emotion/affect_behav0.63195449

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.17835593
2Abnormality of liposaccharide metabolism (HP:0010968)7.17835593
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.17835593
4Increased cerebral lipofuscin (HP:0011813)5.61341639
5Neurofibrillary tangles (HP:0002185)4.81177100
6Increased neuronal autofluorescent lipopigment (HP:0002074)4.72059888
7Vacuolated lymphocytes (HP:0001922)4.51514063
8Dysostosis multiplex (HP:0000943)4.50776583
9Mutism (HP:0002300)4.16256519
10Abnormality of macrophages (HP:0004311)4.01385842
11Loss of speech (HP:0002371)3.89510889
12Cerebral inclusion bodies (HP:0100314)3.87436058
13Disinhibition (HP:0000734)3.78727970
14Supranuclear gaze palsy (HP:0000605)3.76174601
15Recurrent bacterial skin infections (HP:0005406)3.69082299
16Recurrent abscess formation (HP:0002722)3.64024221
17Eczematoid dermatitis (HP:0000976)3.60249383
18Systemic lupus erythematosus (HP:0002725)3.58178569
19Neuronal loss in central nervous system (HP:0002529)3.49654675
20Apathy (HP:0000741)3.47787445
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.40595870
22Diminished motivation (HP:0000745)3.38482813
23Axonal loss (HP:0003447)3.36855670
24Abnormality of polysaccharide metabolism (HP:0011012)3.31819522
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.31819522
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.31819522
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.27292425
28Mucopolysacchariduria (HP:0008155)3.21004541
29Urinary glycosaminoglycan excretion (HP:0003541)3.21004541
30Recurrent gram-negative bacterial infections (HP:0005420)2.84997459
31Diplopia (HP:0000651)2.71260564
32Abnormality of binocular vision (HP:0011514)2.71260564
33Mediastinal lymphadenopathy (HP:0100721)2.70607008
34Amyloidosis (HP:0011034)2.70388489
35Upper motor neuron abnormality (HP:0002127)2.62793468
36Visual hallucinations (HP:0002367)2.62459859
37Dementia (HP:0000726)2.60153463
38Nuclear cataract (HP:0100018)2.57208753
39Purpura (HP:0000979)2.55726820
40Global brain atrophy (HP:0002283)2.54718485
41Inappropriate behavior (HP:0000719)2.42452098
42Chronic obstructive pulmonary disease (HP:0006510)2.40592776
43Obstructive lung disease (HP:0006536)2.40592776
44Abnormality of the periventricular white matter (HP:0002518)2.39326264
45Thoracic kyphosis (HP:0002942)2.37656690
46Peripheral hypomyelination (HP:0007182)2.28003212
47Myocardial infarction (HP:0001658)2.26659481
48Gingivitis (HP:0000230)2.26107612
49Personality changes (HP:0000751)2.25401661
50Recurrent skin infections (HP:0001581)2.24921738
51Ocular albinism (HP:0001107)2.17397526
52Agnosia (HP:0010524)2.12014366
53Autoimmune thrombocytopenia (HP:0001973)2.11003716
54Progressive neurologic deterioration (HP:0002344)2.10753508
55Polygenic inheritance (HP:0010982)2.09627792
56Retinal atrophy (HP:0001105)2.08618236
57Hepatosplenomegaly (HP:0001433)2.05912958
58Obstructive sleep apnea (HP:0002870)2.04760404
59Pathologic fracture (HP:0002756)2.01439426
60Peripheral demyelination (HP:0011096)1.98896152
61Ankle clonus (HP:0011448)1.98097871
62Myositis (HP:0100614)1.94817038
63Cellulitis (HP:0100658)1.94428341
64Glomerulonephritis (HP:0000099)1.93596026
65Hyperacusis (HP:0010780)1.93329861
66Spontaneous hematomas (HP:0007420)1.93146385
67Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89722634
68Stomatitis (HP:0010280)1.84351398
69Segmental peripheral demyelination/remyelination (HP:0003481)1.84213358
70Memory impairment (HP:0002354)1.83525242
71Abnormality of the thoracic spine (HP:0100711)1.82564519
72Cerebral aneurysm (HP:0004944)1.82509977
73Urinary incontinence (HP:0000020)1.82381380
74Myokymia (HP:0002411)1.81868184
75Annular pancreas (HP:0001734)1.80694746
76Iris hypopigmentation (HP:0007730)1.79317056
77Truncal ataxia (HP:0002078)1.79249397
78Rapidly progressive (HP:0003678)1.78909020
79Bone pain (HP:0002653)1.78705066
80Action tremor (HP:0002345)1.78428260
81Cardiomegaly (HP:0001640)1.77544115
82Orchitis (HP:0100796)1.77417210
83Vertebral compression fractures (HP:0002953)1.74670711
84Asymmetric septal hypertrophy (HP:0001670)1.73656401
85Progressive visual loss (HP:0000529)1.73046857
86Slow saccadic eye movements (HP:0000514)1.72608263
87Increased serum ferritin (HP:0003281)1.71212945
88Increased IgE level (HP:0003212)1.67704542
89J-shaped sella turcica (HP:0002680)1.67451516
90Thin bony cortex (HP:0002753)1.64843788
91Recurrent fungal infections (HP:0002841)1.64760373
92Urticaria (HP:0001025)1.63431291
93Abnormal eating behavior (HP:0100738)1.62315818
94Depression (HP:0000716)1.60994271
95Chronic mucocutaneous candidiasis (HP:0002728)1.60014145
96Recurrent cutaneous fungal infections (HP:0011370)1.60014145
97Petechiae (HP:0000967)1.58044603
98Insomnia (HP:0100785)1.57936774
99Rigidity (HP:0002063)1.57610406
100Onion bulb formation (HP:0003383)1.57574598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.55351401
2PRPF4B3.12879094
3TRIB32.37007980
4BLK2.26760283
5MAP3K112.19619881
6IRAK32.09313470
7MAP3K132.06118044
8ERN11.94809308
9MAP2K31.81732884
10CAMKK11.76016998
11NME21.75796115
12SIK21.62167733
13RIPK11.61429515
14PAK61.60994421
15FES1.60305323
16CAMK1D1.60105736
17DAPK21.56394994
18ARAF1.41571137
19TYK21.40211316
20FGR1.39261291
21TGFBR21.38483694
22MARK21.37308246
23MAP3K91.37303672
24CSK1.36710709
25DDR21.34367926
26TAOK11.33366993
27PRKD31.33364333
28MAP4K11.30146755
29CSF1R1.28197128
30TAOK21.27403945
31MAP3K141.26577311
32MAPK121.25042970
33KSR21.24947697
34KIT1.23200280
35GRK71.21889701
36TNK21.18362190
37CAMKK21.18134227
38TBK11.17763687
39ICK1.17278465
40MAP3K11.16054765
41RPS6KA21.16030364
42CDC42BPA1.15562388
43PDPK11.15524040
44MAP3K31.15045243
45EEF2K1.08902755
46ABL21.08694193
47NTRK31.07413888
48ZAP701.06907122
49CAMK1G0.95082978
50PRKD20.94224430
51TYRO30.92146117
52SYK0.91893872
53SMG10.90543806
54IRAK40.89396233
55PDK10.88771344
56MATK0.88259243
57SIK10.86516655
58IRAK20.81791056
59MAP3K60.80090745
60TESK10.77722654
61SGK30.76719556
62PIM20.76506915
63RPS6KL10.74891636
64RPS6KC10.74891636
65MARK10.74097724
66MOS0.72878344
67MAP2K40.71361451
68TTN0.70170507
69LIMK10.70058833
70HCK0.68287112
71UHMK10.67121596
72JAK20.65303393
73MAP2K60.63821120
74MAPK40.63697143
75TESK20.62802520
76NTRK10.61892458
77RPS6KA60.61606368
78CDK50.59539079
79SGK2230.59014420
80SGK4940.59014420
81NTRK20.58534234
82CAMK10.58334022
83LYN0.57911362
84EPHA40.56474042
85MAPK70.54811010
86BTK0.54700855
87PRKG20.54542245
88JAK10.54333324
89PRKCH0.53753005
90IKBKB0.52459288
91ALK0.52321351
92FYN0.52055796
93LATS20.50868914
94BRAF0.50647742
95GRK60.50256661
96CAMK40.48091388
97STK110.46844535
98PDGFRA0.44014351
99JAK30.43145243
100MAP3K20.42995694

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.73120963
2Lysosome_Homo sapiens_hsa041423.15878172
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.35552200
4Osteoclast differentiation_Homo sapiens_hsa043802.32171605
5Staphylococcus aureus infection_Homo sapiens_hsa051502.20384883
6Synaptic vesicle cycle_Homo sapiens_hsa047211.96778321
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96201552
8Leishmaniasis_Homo sapiens_hsa051401.94623579
9Tuberculosis_Homo sapiens_hsa051521.89739514
10Phagosome_Homo sapiens_hsa041451.71848231
11Rheumatoid arthritis_Homo sapiens_hsa053231.65902110
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63724787
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63714081
14Collecting duct acid secretion_Homo sapiens_hsa049661.56831316
15B cell receptor signaling pathway_Homo sapiens_hsa046621.53433985
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44967114
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41817373
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29148681
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29031587
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25975504
21Prion diseases_Homo sapiens_hsa050201.25337497
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24206196
23Pertussis_Homo sapiens_hsa051331.22019387
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21804835
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21741322
26VEGF signaling pathway_Homo sapiens_hsa043701.21555973
27GnRH signaling pathway_Homo sapiens_hsa049121.20363802
28Asthma_Homo sapiens_hsa053101.20276157
29Long-term potentiation_Homo sapiens_hsa047201.19288538
30Salmonella infection_Homo sapiens_hsa051321.18980949
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.15018685
32Malaria_Homo sapiens_hsa051441.13674101
33Toxoplasmosis_Homo sapiens_hsa051451.13517842
34Acute myeloid leukemia_Homo sapiens_hsa052211.10617448
35Allograft rejection_Homo sapiens_hsa053301.07396465
36Chemokine signaling pathway_Homo sapiens_hsa040621.04032226
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.02999049
38Vibrio cholerae infection_Homo sapiens_hsa051100.99603340
39Sphingolipid signaling pathway_Homo sapiens_hsa040710.96260774
40Antigen processing and presentation_Homo sapiens_hsa046120.96034596
41Graft-versus-host disease_Homo sapiens_hsa053320.95747625
42Estrogen signaling pathway_Homo sapiens_hsa049150.92237263
43TNF signaling pathway_Homo sapiens_hsa046680.90830818
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89387517
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87065079
46Intestinal immune network for IgA production_Homo sapiens_hsa046720.86926541
47Endocytosis_Homo sapiens_hsa041440.86402520
48Autoimmune thyroid disease_Homo sapiens_hsa053200.85863405
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84235128
50Gastric acid secretion_Homo sapiens_hsa049710.79854313
51Amoebiasis_Homo sapiens_hsa051460.78553407
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77466703
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76402820
54Bladder cancer_Homo sapiens_hsa052190.75030234
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.75017555
56Influenza A_Homo sapiens_hsa051640.74373029
57Morphine addiction_Homo sapiens_hsa050320.74342248
58Glioma_Homo sapiens_hsa052140.74059477
59Hematopoietic cell lineage_Homo sapiens_hsa046400.73050421
60Notch signaling pathway_Homo sapiens_hsa043300.72303904
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.71802488
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69729503
63Oxytocin signaling pathway_Homo sapiens_hsa049210.69450628
64Renal cell carcinoma_Homo sapiens_hsa052110.69273747
65Chronic myeloid leukemia_Homo sapiens_hsa052200.67855898
66Type I diabetes mellitus_Homo sapiens_hsa049400.66931618
67Shigellosis_Homo sapiens_hsa051310.66088518
68ErbB signaling pathway_Homo sapiens_hsa040120.66079538
69Glutamatergic synapse_Homo sapiens_hsa047240.65966842
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65835366
71Sphingolipid metabolism_Homo sapiens_hsa006000.65806347
72Non-small cell lung cancer_Homo sapiens_hsa052230.65505900
73Cholinergic synapse_Homo sapiens_hsa047250.65230897
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65104531
75Circadian entrainment_Homo sapiens_hsa047130.64049864
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63683284
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63190741
78MAPK signaling pathway_Homo sapiens_hsa040100.61793817
79Hepatitis C_Homo sapiens_hsa051600.61438075
80Legionellosis_Homo sapiens_hsa051340.60870074
81T cell receptor signaling pathway_Homo sapiens_hsa046600.60714567
82Type II diabetes mellitus_Homo sapiens_hsa049300.60509618
83Viral myocarditis_Homo sapiens_hsa054160.59718238
84Platelet activation_Homo sapiens_hsa046110.59295201
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59288769
86Apoptosis_Homo sapiens_hsa042100.58691482
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57198886
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.57082752
89Prolactin signaling pathway_Homo sapiens_hsa049170.56944007
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56877964
91Rap1 signaling pathway_Homo sapiens_hsa040150.56586961
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55975594
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54911091
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53100204
95Renin secretion_Homo sapiens_hsa049240.51625997
96GABAergic synapse_Homo sapiens_hsa047270.50398990
97Dopaminergic synapse_Homo sapiens_hsa047280.49494182
98Hepatitis B_Homo sapiens_hsa051610.48836630
99Galactose metabolism_Homo sapiens_hsa000520.48822705
100mTOR signaling pathway_Homo sapiens_hsa041500.48742711

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