KIAA1024

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)8.06569544
2glucocorticoid metabolic process (GO:0008211)6.11281221
3embryonic retina morphogenesis in camera-type eye (GO:0060059)3.96572111
4C21-steroid hormone biosynthetic process (GO:0006700)3.93533823
5axonal fasciculation (GO:0007413)3.92940470
6regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.91448775
7cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.58852001
8neuron recognition (GO:0008038)3.56685233
9androgen biosynthetic process (GO:0006702)3.55818553
10axon extension (GO:0048675)3.55417958
11regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.50903394
12neuron projection extension (GO:1990138)3.35698886
13protein localization to synapse (GO:0035418)3.33891328
14glutamate secretion (GO:0014047)3.32053807
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28861956
16positive regulation of synapse assembly (GO:0051965)3.28649233
17central nervous system projection neuron axonogenesis (GO:0021952)3.28497932
18response to follicle-stimulating hormone (GO:0032354)3.27799861
19nuclear pore complex assembly (GO:0051292)3.22259285
20positive regulation of dendritic spine morphogenesis (GO:0061003)3.16563497
21myotube differentiation (GO:0014902)3.15805108
22presynaptic membrane organization (GO:0097090)3.13248208
23postsynaptic membrane organization (GO:0001941)3.11818731
24negative regulation of neurological system process (GO:0031645)3.11350045
25protein localization to microtubule (GO:0035372)3.10172419
26response to insecticide (GO:0017085)3.09463605
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.06985819
28layer formation in cerebral cortex (GO:0021819)3.06477031
29tachykinin receptor signaling pathway (GO:0007217)3.04895504
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.98955951
31astrocyte development (GO:0014002)2.97664193
32positive regulation of dendritic spine development (GO:0060999)2.93578889
33ionotropic glutamate receptor signaling pathway (GO:0035235)2.92728915
34regulation of respiratory system process (GO:0044065)2.90516558
35mating behavior (GO:0007617)2.90181395
36presynaptic membrane assembly (GO:0097105)2.85888245
37nuclear pore organization (GO:0006999)2.85802618
38cellular response to gonadotropin stimulus (GO:0071371)2.83000562
39embryonic body morphogenesis (GO:0010172)2.81301674
40cochlea development (GO:0090102)2.81273257
41apical protein localization (GO:0045176)2.81031621
42regulation of transmission of nerve impulse (GO:0051969)2.80363525
43exploration behavior (GO:0035640)2.79745016
44long-term memory (GO:0007616)2.78813448
45regulation of synaptic vesicle exocytosis (GO:2000300)2.75924093
46startle response (GO:0001964)2.74526071
47regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.74229604
48positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.74229604
49regulation of axon extension involved in axon guidance (GO:0048841)2.72238405
50developmental cell growth (GO:0048588)2.71814238
51synaptic vesicle docking involved in exocytosis (GO:0016081)2.70184528
52dermatan sulfate biosynthetic process (GO:0030208)2.69209754
53cellular response to catecholamine stimulus (GO:0071870)2.68799946
54cellular response to monoamine stimulus (GO:0071868)2.68799946
55regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.68321641
56central nervous system neuron axonogenesis (GO:0021955)2.68086490
57dendrite morphogenesis (GO:0048813)2.65296897
58response to methylmercury (GO:0051597)2.65186729
59synaptic vesicle maturation (GO:0016188)2.59510562
60regulation of respiratory gaseous exchange (GO:0043576)2.59413947
61synaptic transmission, glutamatergic (GO:0035249)2.58344110
62suckling behavior (GO:0001967)2.56809080
63cell migration in hindbrain (GO:0021535)2.56665763
64locomotory exploration behavior (GO:0035641)2.56603179
65body morphogenesis (GO:0010171)2.56395398
66regulation of neuron migration (GO:2001222)2.55902851
67cellular sodium ion homeostasis (GO:0006883)2.55234586
68neurotransmitter-gated ion channel clustering (GO:0072578)2.54746409
69sodium ion export (GO:0071436)2.54673235
70cranial nerve morphogenesis (GO:0021602)2.53813513
71establishment of mitochondrion localization (GO:0051654)2.53675295
72atrial cardiac muscle cell action potential (GO:0086014)2.53568583
73cellular response to antibiotic (GO:0071236)2.53433090
74establishment of nucleus localization (GO:0040023)2.53009735
75regulation of axon guidance (GO:1902667)2.52927562
76positive regulation of hormone biosynthetic process (GO:0046886)2.52318432
77neuron-neuron synaptic transmission (GO:0007270)2.52227147
78neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.51441395
79positive regulation of steroid biosynthetic process (GO:0010893)2.51178330
80regulation of synapse assembly (GO:0051963)2.51145692
81pyrimidine nucleobase catabolic process (GO:0006208)2.50918361
82regulation of synaptic vesicle transport (GO:1902803)2.50298423
83organelle transport along microtubule (GO:0072384)2.50217918
84neuron cell-cell adhesion (GO:0007158)2.50041233
85dendritic spine morphogenesis (GO:0060997)2.49705207
86regulation of synaptic transmission, GABAergic (GO:0032228)2.49436865
87negative chemotaxis (GO:0050919)2.48282835
88regulation of transforming growth factor beta2 production (GO:0032909)2.47863314
89vocalization behavior (GO:0071625)2.47288151
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.45030560
91cellular potassium ion homeostasis (GO:0030007)2.42658863
92regulation of neuronal synaptic plasticity (GO:0048168)2.42099685
93neurotransmitter secretion (GO:0007269)2.41810912
94glutamate receptor signaling pathway (GO:0007215)2.41677614
95dermatan sulfate metabolic process (GO:0030205)2.38781330
96neuronal ion channel clustering (GO:0045161)2.38386804
97regulation of female receptivity (GO:0045924)2.37302072
98mitochondrion transport along microtubule (GO:0047497)2.33823897
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33823897
100negative regulation of dendrite development (GO:2000171)2.32624272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.20626938
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.83433500
3GBX2_23144817_ChIP-Seq_PC3_Human3.07043861
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.95703042
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38214886
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33639175
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.33585824
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22135311
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19273721
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16934098
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14395045
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14395045
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.12574668
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.11776867
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02269234
16PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00515143
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.99906351
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.95145493
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92617222
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90142286
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88757652
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87294318
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84859990
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.83209763
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.81911908
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.81099473
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77276302
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.76017515
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75250468
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74109222
31SMAD4_21799915_ChIP-Seq_A2780_Human1.69043742
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68889362
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.68133944
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67314068
35RNF2_27304074_Chip-Seq_NSC_Mouse1.65207205
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62591886
37TAF15_26573619_Chip-Seq_HEK293_Human1.61666503
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58994870
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57887581
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56900881
41* DROSHA_22980978_ChIP-Seq_HELA_Human1.54580439
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52931725
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50334073
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50201540
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49952035
46REST_21632747_ChIP-Seq_MESCs_Mouse1.49212518
47TP53_18474530_ChIP-ChIP_U2OS_Human1.49045750
48RING1B_27294783_Chip-Seq_NPCs_Mouse1.43348125
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42580701
50YAP1_20516196_ChIP-Seq_MESCs_Mouse1.42364160
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41819636
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41807408
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40995334
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38171326
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36483787
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.36231534
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35908987
58* AR_21572438_ChIP-Seq_LNCaP_Human1.35059733
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34562516
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34562516
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33595614
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32021788
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.30512895
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30455999
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30404960
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30337279
67STAT3_23295773_ChIP-Seq_U87_Human1.29600224
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29494075
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.29492147
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28327218
71P300_19829295_ChIP-Seq_ESCs_Human1.26113376
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25164267
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23427665
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22828727
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22777639
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21265781
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.20585429
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20370821
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19136689
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.17705477
81AR_25329375_ChIP-Seq_VCAP_Human1.16985952
82* SMAD3_21741376_ChIP-Seq_HESCs_Human1.16686994
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16603670
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13432996
85TCF4_23295773_ChIP-Seq_U87_Human1.12222177
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.12001812
87FUS_26573619_Chip-Seq_HEK293_Human1.11376457
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09928887
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.09548907
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09138113
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09005132
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08452095
93* AR_19668381_ChIP-Seq_PC3_Human1.06902997
94REST_18959480_ChIP-ChIP_MESCs_Mouse1.05704719
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05268043
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05268043
97* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03641590
98TP53_16413492_ChIP-PET_HCT116_Human1.03225586
99KDM2B_26808549_Chip-Seq_REH_Human1.03082803
100GF1_26923725_Chip-Seq_HPCs_Mouse1.02886263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous3.40811817
2MP0008438_abnormal_cutaneous_collagen3.37544154
3MP0000569_abnormal_digit_pigmentation3.36767008
4MP0004859_abnormal_synaptic_plasticity3.32767534
5MP0000778_abnormal_nervous_system2.53508068
6MP0003880_abnormal_central_pattern2.40401386
7MP0003635_abnormal_synaptic_transmissio2.30580765
8MP0004270_analgesia2.29807189
9MP0003890_abnormal_embryonic-extraembry2.15903973
10MP0005275_abnormal_skin_tensile2.13274017
11MP0002909_abnormal_adrenal_gland2.10012830
12MP0002184_abnormal_innervation2.06810011
13MP0005503_abnormal_tendon_morphology2.04592918
14MP0002734_abnormal_mechanical_nocicepti1.99425163
15MP0000534_abnormal_ureter_morphology1.95376917
16MP0002822_catalepsy1.92469037
17MP0002063_abnormal_learning/memory/cond1.87173778
18MP0000639_abnormal_adrenal_gland1.85304231
19MP0005257_abnormal_intraocular_pressure1.81306856
20MP0004924_abnormal_behavior1.60209798
21MP0005386_behavior/neurological_phenoty1.60209798
22MP0003385_abnormal_body_wall1.58386330
23MP0002572_abnormal_emotion/affect_behav1.57719570
24MP0006276_abnormal_autonomic_nervous1.55725212
25MP0003283_abnormal_digestive_organ1.54350026
26MP0009250_abnormal_appendicular_skeleto1.52209692
27MP0002735_abnormal_chemical_nociception1.51410380
28MP0005171_absent_coat_pigmentation1.51203823
29MP0001984_abnormal_olfaction1.48947663
30MP0005409_darkened_coat_color1.48033631
31MP0001299_abnormal_eye_distance/1.47623289
32MP0001486_abnormal_startle_reflex1.46468195
33MP0009053_abnormal_anal_canal1.45510706
34MP0005187_abnormal_penis_morphology1.44149345
35MP0008569_lethality_at_weaning1.42202304
36MP0000955_abnormal_spinal_cord1.40738856
37MP0009046_muscle_twitch1.37883141
38MP0002272_abnormal_nervous_system1.37772650
39MP0004811_abnormal_neuron_physiology1.36061150
40MP0008057_abnormal_DNA_replication1.34896690
41MP0003937_abnormal_limbs/digits/tail_de1.34644115
42MP0003942_abnormal_urinary_system1.34322864
43MP0001529_abnormal_vocalization1.31194389
44MP0004742_abnormal_vestibular_system1.27066900
45MP0009745_abnormal_behavioral_response1.26900337
46MP0010368_abnormal_lymphatic_system1.25485111
47MP0002877_abnormal_melanocyte_morpholog1.24781340
48MP0002882_abnormal_neuron_morphology1.23102704
49MP0002064_seizures1.22701922
50MP0002557_abnormal_social/conspecific_i1.21801312
51MP0002102_abnormal_ear_morphology1.17329718
52MP0004134_abnormal_chest_morphology1.16649668
53MP0000462_abnormal_digestive_system1.14691219
54MP0003861_abnormal_nervous_system1.13455341
55MP0000015_abnormal_ear_pigmentation1.13264264
56MP0003935_abnormal_craniofacial_develop1.13005066
57MP0001188_hyperpigmentation1.11967148
58MP0000631_abnormal_neuroendocrine_gland1.08704489
59MP0002067_abnormal_sensory_capabilities1.07917938
60MP0000537_abnormal_urethra_morphology1.07531139
61MP0002152_abnormal_brain_morphology1.07112482
62MP0002177_abnormal_outer_ear1.02981806
63MP0001958_emphysema1.01860609
64MP0003123_paternal_imprinting1.01130332
65MP0002081_perinatal_lethality1.00981284
66MP0003122_maternal_imprinting0.97642949
67MP0005197_abnormal_uvea_morphology0.96027103
68MP0001970_abnormal_pain_threshold0.95647288
69MP0004272_abnormal_basement_membrane0.94021396
70MP0004885_abnormal_endolymph0.93419738
71MP0000428_abnormal_craniofacial_morphol0.91869496
72MP0001177_atelectasis0.91777863
73MP0003329_amyloid_beta_deposits0.91690129
74MP0003943_abnormal_hepatobiliary_system0.91649474
75MP0003121_genomic_imprinting0.91008744
76MP0001440_abnormal_grooming_behavior0.90829625
77MP0001502_abnormal_circadian_rhythm0.90200620
78MP0001879_abnormal_lymphatic_vessel0.88914648
79MP0002932_abnormal_joint_morphology0.88586872
80MP0002697_abnormal_eye_size0.87114965
81MP0002234_abnormal_pharynx_morphology0.86760308
82MP0002116_abnormal_craniofacial_bone0.86430321
83MP0002066_abnormal_motor_capabilities/c0.84371967
84MP0003755_abnormal_palate_morphology0.84265509
85MP0005623_abnormal_meninges_morphology0.83327264
86MP0001968_abnormal_touch/_nociception0.80585039
87MP0002751_abnormal_autonomic_nervous0.80024074
88MP0000432_abnormal_head_morphology0.79944848
89MP0001915_intracranial_hemorrhage0.79375343
90MP0003091_abnormal_cell_migration0.79341199
91MP0002114_abnormal_axial_skeleton0.78524470
92MP0003634_abnormal_glial_cell0.78407341
93MP0008770_decreased_survivor_rate0.76775548
94MP0001905_abnormal_dopamine_level0.76347244
95MP0003705_abnormal_hypodermis_morpholog0.75819602
96MP0002752_abnormal_somatic_nervous0.75804294
97MP0001943_abnormal_respiration0.75545259
98MP0000762_abnormal_tongue_morphology0.75339432
99MP0004233_abnormal_muscle_weight0.74375345
100MP0002233_abnormal_nose_morphology0.74030436

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)3.22786354
2Enlarged penis (HP:0000040)3.16409651
3Termporal pattern (HP:0011008)2.85101952
4Insidious onset (HP:0003587)2.85101952
5Drooling (HP:0002307)2.77781239
6Soft skin (HP:0000977)2.74800379
7Abnormality of the lower motor neuron (HP:0002366)2.65206550
8Myokymia (HP:0002411)2.64272863
9Papillary thyroid carcinoma (HP:0002895)2.59749613
10Shawl scrotum (HP:0000049)2.53998894
11Premature rupture of membranes (HP:0001788)2.51629476
12Focal seizures (HP:0007359)2.50026114
13Asymmetry of the thorax (HP:0001555)2.48390313
14Excessive salivation (HP:0003781)2.48178421
15Abnormality of the corticospinal tract (HP:0002492)2.41083754
16Focal motor seizures (HP:0011153)2.40862581
17Febrile seizures (HP:0002373)2.39186581
18Abnormality of dentin (HP:0010299)2.32847106
19Bell-shaped thorax (HP:0001591)2.23199902
20Decreased circulating renin level (HP:0003351)2.21587571
21Amblyopia (HP:0000646)2.12710994
22Wrist flexion contracture (HP:0001239)2.10073154
23Cerebral inclusion bodies (HP:0100314)2.09984856
24Tubulointerstitial nephritis (HP:0001970)2.09551456
25Hammertoe (HP:0001765)2.08489645
26Neurofibrillary tangles (HP:0002185)2.06282910
27Limb dystonia (HP:0002451)2.06058691
28Missing ribs (HP:0000921)2.05699504
29Protrusio acetabuli (HP:0003179)2.03831847
30Morphological abnormality of the middle ear (HP:0008609)2.03092280
31Epileptiform EEG discharges (HP:0011182)2.00887218
32Cubitus valgus (HP:0002967)2.00596189
33Urinary urgency (HP:0000012)1.98517593
34Truncal ataxia (HP:0002078)1.98117946
35Heterochromia iridis (HP:0001100)1.97658585
36Volvulus (HP:0002580)1.97551324
37Hyperextensible skin (HP:0000974)1.97070838
38Bowel diverticulosis (HP:0005222)1.97024972
39Vertebral arch anomaly (HP:0008438)1.96897338
40Mild short stature (HP:0003502)1.96847688
41Action tremor (HP:0002345)1.95499261
42Genu recurvatum (HP:0002816)1.95234514
43EEG with generalized epileptiform discharges (HP:0011198)1.95166441
44Vascular tortuosity (HP:0004948)1.92585236
45Bladder diverticulum (HP:0000015)1.92267985
46Arterial tortuosity (HP:0005116)1.91331517
47Hypsarrhythmia (HP:0002521)1.89253628
48Supranuclear gaze palsy (HP:0000605)1.88915074
49Impaired vibration sensation in the lower limbs (HP:0002166)1.88732591
50Follicular hyperkeratosis (HP:0007502)1.88566189
51Bilateral sensorineural hearing impairment (HP:0008619)1.88494885
52Renovascular hypertension (HP:0100817)1.86699545
53Poor eye contact (HP:0000817)1.85911985
54Short nail (HP:0001799)1.85684618
55Coronal craniosynostosis (HP:0004440)1.83223746
56Epileptic encephalopathy (HP:0200134)1.82956598
57Absent speech (HP:0001344)1.82534776
58Generalized tonic-clonic seizures (HP:0002069)1.80799192
59Spinal cord lesions (HP:0100561)1.80579611
60Syringomyelia (HP:0003396)1.80579611
61Spastic gait (HP:0002064)1.80128253
62Torticollis (HP:0000473)1.77793906
63Overgrowth (HP:0001548)1.77217808
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76404942
65Abnormal umbilical cord blood vessels (HP:0011403)1.74953229
66Single umbilical artery (HP:0001195)1.74953229
67Abnormality of the fetal cardiovascular system (HP:0010948)1.74953229
68Ankyloglossia (HP:0010296)1.73133395
69Renal salt wasting (HP:0000127)1.72264064
70Abnormality of chromosome segregation (HP:0002916)1.72089729
71Thickened helices (HP:0000391)1.71758165
72Wide anterior fontanel (HP:0000260)1.69690193
73Atrophic scars (HP:0001075)1.69008636
74Hypoplasia of the uterus (HP:0000013)1.68303526
75Relative macrocephaly (HP:0004482)1.67387553
76Sacral dimple (HP:0000960)1.66934797
77Fragile skin (HP:0001030)1.66424572
78Impaired social interactions (HP:0000735)1.66384055
79Abnormal social behavior (HP:0012433)1.66384055
80Broad distal phalanx of finger (HP:0009836)1.64212138
81Thyroid carcinoma (HP:0002890)1.63532572
82Broad-based gait (HP:0002136)1.63417842
83Wormian bones (HP:0002645)1.63126965
84Abnormality of the aortic arch (HP:0012303)1.62976070
85Hand muscle atrophy (HP:0009130)1.62703349
86Mitral valve prolapse (HP:0001634)1.62031483
87Urinary bladder sphincter dysfunction (HP:0002839)1.61219863
88Cortical dysplasia (HP:0002539)1.61102636
89Spastic tetraplegia (HP:0002510)1.60984065
90Heterotopia (HP:0002282)1.59642192
91Short clavicles (HP:0000894)1.58432032
92Hypoplasia of the iris (HP:0007676)1.57268955
93Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.56239066
94Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55913561
95Short 4th metacarpal (HP:0010044)1.55913561
96Precocious puberty (HP:0000826)1.55814450
97Cutaneous finger syndactyly (HP:0010554)1.54457344
98Exotropia (HP:0000577)1.53951895
99Hyperaldosteronism (HP:0000859)1.53125065
100Patellar dislocation (HP:0002999)1.52672593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.09188756
2MARK13.88771563
3AKT33.71610241
4NTRK33.58235637
5PNCK3.18344563
6MAP3K92.42917884
7NTRK22.42624382
8CAMK1G2.32358273
9MAP3K42.02777910
10KSR11.99582069
11NTRK11.97872185
12DDR21.97144803
13LATS21.96191937
14CDK121.81403386
15BRD41.70602203
16ERBB31.66927156
17PRKD31.65734749
18CAMK1D1.59566222
19TNIK1.49180845
20SIK21.44293511
21PDGFRA1.43375930
22ERBB41.40156673
23TAF11.36823853
24MINK11.36543656
25CLK11.35747483
26DYRK31.34482724
27MAP2K41.32323903
28TRIM281.30343484
29SGK21.19641855
30MAP2K71.17090763
31PINK11.16121612
32PLK21.16114877
33KSR21.14421367
34BCR1.13156336
35WNK11.08557188
36MAP3K121.08206286
37LATS11.07202959
38SGK2230.95669698
39SGK4940.95669698
40ICK0.95120335
41MAPK130.94706009
42EPHB20.88574557
43TYRO30.87344777
44PRPF4B0.86760606
45CDK50.86326964
46PDGFRB0.86170711
47PAK60.86109233
48PKN20.85281609
49SGK30.85128671
50MTOR0.82702197
51UHMK10.80659769
52STK380.80070798
53CDK150.76131530
54ARAF0.75934631
55CDK180.75483673
56RAF10.73845002
57CSNK1G20.73366512
58EIF2AK30.72944741
59PRKCH0.72839040
60MAP3K20.71549052
61MAP3K60.70294878
62CDK140.68451007
63STK240.65822051
64PLK40.65558075
65PHKG20.63988529
66PHKG10.63988529
67EPHA40.63964432
68RPS6KA20.63288577
69CDK11A0.62719609
70FGFR20.61526643
71PRKCG0.61307991
72WEE10.55699946
73RET0.55448611
74CAMK2B0.54738870
75CDK30.54280518
76STK38L0.53695948
77PRKCZ0.52224089
78CAMKK20.51569086
79MAP3K50.50480735
80SGK10.50135773
81PKN10.49967397
82MET0.49687459
83MELK0.49462206
84SCYL20.49314237
85CAMKK10.48710329
86CSNK1A1L0.47984820
87DYRK1A0.45278317
88MKNK20.44886161
89RIPK10.44710648
90BRAF0.44103553
91MAPK100.43014076
92ROCK20.42916534
93PAK20.42760719
94SIK10.39311515
95MAP3K100.38708372
96CSNK1E0.38504018
97CAMK2A0.36246556
98EEF2K0.33286992
99GSK3B0.33170000
100CSNK1G30.32989229

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.69711195
2Vitamin B6 metabolism_Homo sapiens_hsa007502.31436196
3Aldosterone synthesis and secretion_Homo sapiens_hsa049252.24755761
4Synaptic vesicle cycle_Homo sapiens_hsa047212.08508037
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99884534
6Dorso-ventral axis formation_Homo sapiens_hsa043201.90960284
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90329989
8Glutamatergic synapse_Homo sapiens_hsa047241.88643766
9Long-term potentiation_Homo sapiens_hsa047201.83887529
10Dopaminergic synapse_Homo sapiens_hsa047281.81703994
11Circadian entrainment_Homo sapiens_hsa047131.78328481
12Gap junction_Homo sapiens_hsa045401.77643365
13Cocaine addiction_Homo sapiens_hsa050301.67672524
14Steroid biosynthesis_Homo sapiens_hsa001001.64191423
15Ovarian steroidogenesis_Homo sapiens_hsa049131.58623231
16Amphetamine addiction_Homo sapiens_hsa050311.58289305
17Cholinergic synapse_Homo sapiens_hsa047251.57804812
18GABAergic synapse_Homo sapiens_hsa047271.54166021
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53214374
20ECM-receptor interaction_Homo sapiens_hsa045121.52024535
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49628490
22Insulin secretion_Homo sapiens_hsa049111.46148804
23Morphine addiction_Homo sapiens_hsa050321.42143186
24Melanogenesis_Homo sapiens_hsa049161.36972748
25Estrogen signaling pathway_Homo sapiens_hsa049151.36822514
26ErbB signaling pathway_Homo sapiens_hsa040121.35806767
27TGF-beta signaling pathway_Homo sapiens_hsa043501.31673086
28Long-term depression_Homo sapiens_hsa047301.24240010
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23216581
30Axon guidance_Homo sapiens_hsa043601.21913272
31Hippo signaling pathway_Homo sapiens_hsa043901.21608859
32Gastric acid secretion_Homo sapiens_hsa049711.16600616
33Thyroid hormone synthesis_Homo sapiens_hsa049181.15363483
34Hedgehog signaling pathway_Homo sapiens_hsa043401.11916090
35Wnt signaling pathway_Homo sapiens_hsa043101.11470604
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11242343
37Glioma_Homo sapiens_hsa052141.10346897
38Vibrio cholerae infection_Homo sapiens_hsa051101.08502685
39Circadian rhythm_Homo sapiens_hsa047101.07902096
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.06637382
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06026110
42Focal adhesion_Homo sapiens_hsa045101.02950878
43Dilated cardiomyopathy_Homo sapiens_hsa054141.01297631
44Oocyte meiosis_Homo sapiens_hsa041140.99108111
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98724477
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96409667
47Prion diseases_Homo sapiens_hsa050200.96358429
48Serotonergic synapse_Homo sapiens_hsa047260.94960943
49Amoebiasis_Homo sapiens_hsa051460.94725602
50Prolactin signaling pathway_Homo sapiens_hsa049170.93913098
51GnRH signaling pathway_Homo sapiens_hsa049120.93886836
52Type II diabetes mellitus_Homo sapiens_hsa049300.93547818
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92740029
54Basal cell carcinoma_Homo sapiens_hsa052170.92395761
55Adherens junction_Homo sapiens_hsa045200.90703908
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.90055718
57Renal cell carcinoma_Homo sapiens_hsa052110.89911385
58mTOR signaling pathway_Homo sapiens_hsa041500.89743336
59Alcoholism_Homo sapiens_hsa050340.89002928
60Endometrial cancer_Homo sapiens_hsa052130.88915842
61Melanoma_Homo sapiens_hsa052180.87953305
62Oxytocin signaling pathway_Homo sapiens_hsa049210.87872399
63Taste transduction_Homo sapiens_hsa047420.87338692
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87140097
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87139466
66Proteoglycans in cancer_Homo sapiens_hsa052050.86206353
67Fatty acid biosynthesis_Homo sapiens_hsa000610.84969993
68Renin secretion_Homo sapiens_hsa049240.82913440
69Chronic myeloid leukemia_Homo sapiens_hsa052200.82854045
70Calcium signaling pathway_Homo sapiens_hsa040200.82676853
71Choline metabolism in cancer_Homo sapiens_hsa052310.79929891
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79735218
73Protein digestion and absorption_Homo sapiens_hsa049740.78332856
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75979203
75Salivary secretion_Homo sapiens_hsa049700.75767872
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75139183
77Rap1 signaling pathway_Homo sapiens_hsa040150.74287398
78cAMP signaling pathway_Homo sapiens_hsa040240.73432212
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71865148
80Colorectal cancer_Homo sapiens_hsa052100.71614894
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70292574
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70173870
83MicroRNAs in cancer_Homo sapiens_hsa052060.70037478
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69345807
85Ras signaling pathway_Homo sapiens_hsa040140.66326182
86Small cell lung cancer_Homo sapiens_hsa052220.64421342
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63700155
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63598826
89MAPK signaling pathway_Homo sapiens_hsa040100.62709997
90Pancreatic secretion_Homo sapiens_hsa049720.62252234
91Pathways in cancer_Homo sapiens_hsa052000.61534539
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61329849
93Prostate cancer_Homo sapiens_hsa052150.60625729
94Inositol phosphate metabolism_Homo sapiens_hsa005620.59724978
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59592946
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.58668350
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.57241827
98Pancreatic cancer_Homo sapiens_hsa052120.57232103
99Bile secretion_Homo sapiens_hsa049760.57000745
100Non-small cell lung cancer_Homo sapiens_hsa052230.55682593

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