ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.98944081
2	DNA deamination (GO:0045006)	4.60795281
3	L-fucose catabolic process (GO:0042355)	4.52900337
4	fucose catabolic process (GO:0019317)	4.52900337
5	L-fucose metabolic process (GO:0042354)	4.52900337
6	negative regulation of telomere maintenance (GO:0032205)	3.84118860
7	protein polyglutamylation (GO:0018095)	3.79824904
8	axoneme assembly (GO:0035082)	3.55228501
9	cytidine metabolic process (GO:0046087)	3.53980163
10	cytidine catabolic process (GO:0006216)	3.53980163
11	cytidine deamination (GO:0009972)	3.53980163
12	sulfation (GO:0051923)	3.50633932
13	indole-containing compound catabolic process (GO:0042436)	3.49456532
14	indolalkylamine catabolic process (GO:0046218)	3.49456532
15	tryptophan catabolic process (GO:0006569)	3.49456532
16	detection of light stimulus involved in visual perception (GO:0050908)	3.46414712
17	detection of light stimulus involved in sensory perception (GO:0050962)	3.46414712
18	cell proliferation in forebrain (GO:0021846)	3.46308723
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.40622653
20	negative regulation of mast cell activation (GO:0033004)	3.38344337
21	kynurenine metabolic process (GO:0070189)	3.34650393
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.29435030
23	indolalkylamine metabolic process (GO:0006586)	3.29007382
24	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.20777868
25	otic vesicle formation (GO:0030916)	3.20366586
26	response to pheromone (GO:0019236)	3.20144371
27	neuronal action potential (GO:0019228)	3.17437438
28	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.13941135
29	tryptophan metabolic process (GO:0006568)	3.02376802
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.02066789
31	platelet dense granule organization (GO:0060155)	3.01118351
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00294881
33	nephron epithelium morphogenesis (GO:0072088)	2.93342584
34	nephron tubule morphogenesis (GO:0072078)	2.93342584
35	epithelial cilium movement (GO:0003351)	2.93192312
36	protein complex biogenesis (GO:0070271)	2.91322740
37	photoreceptor cell development (GO:0042461)	2.90168473
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.89929932
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.89929932
40	NADH dehydrogenase complex assembly (GO:0010257)	2.89929932
41	cellular ketone body metabolic process (GO:0046950)	2.87243345
42	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.86454798
43	cellular response to ATP (GO:0071318)	2.85559059
44	kidney morphogenesis (GO:0060993)	2.84224361
45	synaptic transmission, cholinergic (GO:0007271)	2.83966052
46	cellular biogenic amine catabolic process (GO:0042402)	2.81522242
47	amine catabolic process (GO:0009310)	2.81522242
48	piRNA metabolic process (GO:0034587)	2.74470793
49	regulation of mesoderm development (GO:2000380)	2.74249889
50	positive regulation of defense response to virus by host (GO:0002230)	2.72438449
51	base-excision repair, AP site formation (GO:0006285)	2.70792671
52	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.69658146
53	gamma-aminobutyric acid transport (GO:0015812)	2.67305419
54	positive regulation of cAMP-mediated signaling (GO:0043950)	2.67177413
55	adaptation of signaling pathway (GO:0023058)	2.66300606
56	transmission of nerve impulse (GO:0019226)	2.65798161
57	regulation of action potential (GO:0098900)	2.64804292
58	mannosylation (GO:0097502)	2.62450180
59	eye photoreceptor cell development (GO:0042462)	2.60965426
60	somite development (GO:0061053)	2.60829417
61	protein neddylation (GO:0045116)	2.60785685
62	GPI anchor metabolic process (GO:0006505)	2.59365585
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.58653570
64	parturition (GO:0007567)	2.58251939
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56806552
66	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56806552
67	indole-containing compound metabolic process (GO:0042430)	2.56401376
68	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.55053098
69	pyrimidine nucleobase catabolic process (GO:0006208)	2.54577176
70	ketone body metabolic process (GO:1902224)	2.53479243
71	primary amino compound metabolic process (GO:1901160)	2.52635534
72	pharyngeal system development (GO:0060037)	2.52553715
73	rhodopsin mediated signaling pathway (GO:0016056)	2.50839294
74	regulation of telomere maintenance (GO:0032204)	2.50774950
75	head development (GO:0060322)	2.47760289
76	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.47234387
77	mesonephros development (GO:0001823)	2.45443291
78	cilium movement (GO:0003341)	2.43889304
79	positive regulation of meiosis (GO:0045836)	2.43242921
80	regulation of cilium movement (GO:0003352)	2.43047795
81	positive regulation of fatty acid transport (GO:2000193)	2.42802314
82	retinal cone cell development (GO:0046549)	2.41977643
83	protein-cofactor linkage (GO:0018065)	2.41803372
84	limb bud formation (GO:0060174)	2.38085831
85	behavioral response to ethanol (GO:0048149)	2.37710597
86	endoderm formation (GO:0001706)	2.37695383
87	negative regulation of systemic arterial blood pressure (GO:0003085)	2.37229970
88	DNA methylation involved in gamete generation (GO:0043046)	2.36838520
89	adenosine metabolic process (GO:0046085)	2.36386183
90	rRNA catabolic process (GO:0016075)	2.36208513
91	respiratory chain complex IV assembly (GO:0008535)	2.35976147
92	positive regulation of fatty acid oxidation (GO:0046321)	2.35377983
93	protein localization to cilium (GO:0061512)	2.33610663
94	reflex (GO:0060004)	2.32500332
95	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.32435523
96	ATP synthesis coupled proton transport (GO:0015986)	2.32435523
97	positive regulation of gastrulation (GO:2000543)	2.32419053
98	neural tube formation (GO:0001841)	2.32232546
99	nonmotile primary cilium assembly (GO:0035058)	2.31238157
100	photoreceptor cell maintenance (GO:0045494)	2.29310315

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.15035241
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.55435367
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.39852801
4	VDR_22108803_ChIP-Seq_LS180_Human	3.08554723
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84622822
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.79653039
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.38895049
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36916141
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30912644
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21191384
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07562791
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03225934
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00505816
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90401444
15	EWS_26573619_Chip-Seq_HEK293_Human	1.88623446
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88370059
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.83270192
18	P300_19829295_ChIP-Seq_ESCs_Human	1.82102087
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.77507921
20	FUS_26573619_Chip-Seq_HEK293_Human	1.76525647
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.74936123
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74880225
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70122606
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.67804918
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.67299920
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.64869479
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63702985
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.57097920
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.56509414
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56508990
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54522387
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.53921211
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53764627
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.50381316
35	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45794370
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.44974868
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44974868
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44802412
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38609129
40	AR_25329375_ChIP-Seq_VCAP_Human	1.36949597
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36652249
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.36227076
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.36227020
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34073890
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.33596903
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32251103
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32251103
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32034480
49	STAT3_23295773_ChIP-Seq_U87_Human	1.30991604
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30517491
51	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.29860220
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29403478
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29403478
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29237674
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28146756
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27432751
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.27282214
58	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.27124807
59	NCOR_22424771_ChIP-Seq_293T_Human	1.26402345
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.26253129
61	TCF4_23295773_ChIP-Seq_U87_Human	1.24909416
62	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.24280180
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.22774301
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22076716
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19763970
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19720774
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.17623911
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17623911
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17396396
70	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.17278555
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16611844
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.16478812
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15982946
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.15115822
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14903726
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14510502
77	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.13901249
78	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.13663251
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.13366950
80	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.12025853
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11324766
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11241759
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10434170
84	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.09826508
85	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.09415334
86	AR_20517297_ChIP-Seq_VCAP_Human	1.08016553
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07600433
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06218662
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06065339
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04813739
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03169473
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02542276
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01866989
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01726259
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00832514
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98924900
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98900445
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.96454311
99	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96190034
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95972658

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.69185456
2	MP0000569_abnormal_digit_pigmentation	2.49151697
3	MP0001968_abnormal_touch/_nociception	2.43610135
4	MP0005551_abnormal_eye_electrophysiolog	2.41858732
5	MP0006292_abnormal_olfactory_placode	2.36512675
6	MP0002837_dystrophic_cardiac_calcinosis	2.33412052
7	MP0003880_abnormal_central_pattern	2.30164970
8	MP0002160_abnormal_reproductive_system	2.29369840
9	MP0005646_abnormal_pituitary_gland	2.25452574
10	MP0002736_abnormal_nociception_after	2.23077925
11	MP0002138_abnormal_hepatobiliary_system	2.17879494
12	MP0003787_abnormal_imprinting	2.14252983
13	MP0004885_abnormal_endolymph	2.12748796
14	MP0002102_abnormal_ear_morphology	2.12040015
15	MP0005083_abnormal_biliary_tract	2.03074195
16	MP0002653_abnormal_ependyma_morphology	2.02018661
17	MP0008872_abnormal_physiological_respon	1.99751513
18	MP0002876_abnormal_thyroid_physiology	1.98875379
19	MP0003195_calcinosis	1.98860982
20	MP0006072_abnormal_retinal_apoptosis	1.92645854
21	MP0004147_increased_porphyrin_level	1.88469272
22	MP0005389_reproductive_system_phenotype	1.87825848
23	MP0009745_abnormal_behavioral_response	1.71193635
24	MP0004142_abnormal_muscle_tone	1.69381899
25	MP0001986_abnormal_taste_sensitivity	1.68392199
26	MP0005084_abnormal_gallbladder_morpholo	1.67676942
27	MP0004043_abnormal_pH_regulation	1.65936550
28	MP0009046_muscle_twitch	1.64938828
29	MP0000631_abnormal_neuroendocrine_gland	1.64368065
30	MP0002272_abnormal_nervous_system	1.62415098
31	MP0008875_abnormal_xenobiotic_pharmacok	1.61390524
32	MP0005253_abnormal_eye_physiology	1.60875639
33	MP0002638_abnormal_pupillary_reflex	1.59154779
34	MP0002928_abnormal_bile_duct	1.58591267
35	MP0003011_delayed_dark_adaptation	1.58341582
36	MP0005645_abnormal_hypothalamus_physiol	1.56069156
37	MP0006276_abnormal_autonomic_nervous	1.50420132
38	MP0002938_white_spotting	1.48439805
39	MP0002735_abnormal_chemical_nociception	1.48258368
40	MP0001486_abnormal_startle_reflex	1.43611298
41	MP0002733_abnormal_thermal_nociception	1.42833701
42	MP0002234_abnormal_pharynx_morphology	1.42713644
43	MP0004133_heterotaxia	1.40828417
44	MP0003283_abnormal_digestive_organ	1.38010689
45	MP0003136_yellow_coat_color	1.37618304
46	MP0005671_abnormal_response_to	1.35441005
47	MP0001970_abnormal_pain_threshold	1.32005623
48	MP0001485_abnormal_pinna_reflex	1.31881322
49	MP0004742_abnormal_vestibular_system	1.30177055
50	MP0002163_abnormal_gland_morphology	1.28893168
51	MP0005174_abnormal_tail_pigmentation	1.28667251
52	MP0003646_muscle_fatigue	1.27854499
53	MP0002572_abnormal_emotion/affect_behav	1.24095364
54	MP0000427_abnormal_hair_cycle	1.23059518
55	MP0002557_abnormal_social/conspecific_i	1.21697679
56	MP0000049_abnormal_middle_ear	1.20722379
57	MP0002064_seizures	1.19660307
58	MP0001919_abnormal_reproductive_system	1.17950115
59	MP0000372_irregular_coat_pigmentation	1.16777963
60	MP0001501_abnormal_sleep_pattern	1.12076921
61	MP0004145_abnormal_muscle_electrophysio	1.08691787
62	MP0003121_genomic_imprinting	1.03484351
63	MP0003635_abnormal_synaptic_transmissio	1.02361494
64	MP0002822_catalepsy	1.00089641
65	MP0001984_abnormal_olfaction	1.00052768
66	MP0005195_abnormal_posterior_eye	0.98974459
67	MP0003252_abnormal_bile_duct	0.98339224
68	MP0005423_abnormal_somatic_nervous	0.97664134
69	MP0002063_abnormal_learning/memory/cond	0.97050051
70	MP0000026_abnormal_inner_ear	0.96967189
71	MP0002734_abnormal_mechanical_nocicepti	0.96866602
72	MP0002254_reproductive_system_inflammat	0.95963904
73	MP0010386_abnormal_urinary_bladder	0.95462033
74	MP0002067_abnormal_sensory_capabilities	0.94012173
75	MP0005379_endocrine/exocrine_gland_phen	0.93901894
76	MP0004924_abnormal_behavior	0.93238053
77	MP0005386_behavior/neurological_phenoty	0.93238053
78	MP0003890_abnormal_embryonic-extraembry	0.92201020
79	MP0000383_abnormal_hair_follicle	0.91869438
80	MP0001905_abnormal_dopamine_level	0.91215387
81	MP0005085_abnormal_gallbladder_physiolo	0.90559182
82	MP0002184_abnormal_innervation	0.90369324
83	MP0001529_abnormal_vocalization	0.87833024
84	MP0003122_maternal_imprinting	0.87575613
85	MP0002752_abnormal_somatic_nervous	0.86923713
86	MP0001963_abnormal_hearing_physiology	0.86869585
87	MP0008995_early_reproductive_senescence	0.85211507
88	MP0000230_abnormal_systemic_arterial	0.83725812
89	MP0000613_abnormal_salivary_gland	0.83499992
90	MP0000778_abnormal_nervous_system	0.82536267
91	MP0002693_abnormal_pancreas_physiology	0.80623029
92	MP0003137_abnormal_impulse_conducting	0.79722771
93	MP0003119_abnormal_digestive_system	0.78324780
94	MP0001440_abnormal_grooming_behavior	0.77491607
95	MP0002751_abnormal_autonomic_nervous	0.77487830
96	MP0002095_abnormal_skin_pigmentation	0.77460999
97	MP0005075_abnormal_melanosome_morpholog	0.77010812
98	MP0005377_hearing/vestibular/ear_phenot	0.75321919
99	MP0003878_abnormal_ear_physiology	0.75321919
100	MP0001502_abnormal_circadian_rhythm	0.74828680

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.94373819
2	Pancreatic fibrosis (HP:0100732)	4.69393276
3	True hermaphroditism (HP:0010459)	4.65388611
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.99666648
5	Congenital stationary night blindness (HP:0007642)	3.96208828
6	Pendular nystagmus (HP:0012043)	3.88133385
7	Abnormality of midbrain morphology (HP:0002418)	3.83247136
8	Molar tooth sign on MRI (HP:0002419)	3.83247136
9	Abnormal rod and cone electroretinograms (HP:0008323)	3.64988734
10	Nephronophthisis (HP:0000090)	3.51264296
11	Abolished electroretinogram (ERG) (HP:0000550)	3.49018305
12	Attenuation of retinal blood vessels (HP:0007843)	3.25661509
13	Cystic liver disease (HP:0006706)	3.20187425
14	Decreased central vision (HP:0007663)	3.19222655
15	Keratoconus (HP:0000563)	3.07002751
16	Increased corneal curvature (HP:0100692)	3.07002751
17	Abnormality of the renal medulla (HP:0100957)	2.97500985
18	Medial flaring of the eyebrow (HP:0010747)	2.91986015
19	Severe visual impairment (HP:0001141)	2.89965988
20	Sclerocornea (HP:0000647)	2.87861390
21	Abnormality of the renal cortex (HP:0011035)	2.85269362
22	Hyperventilation (HP:0002883)	2.66209075
23	Type II lissencephaly (HP:0007260)	2.54833976
24	Gait imbalance (HP:0002141)	2.50970583
25	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.47075750
26	Anencephaly (HP:0002323)	2.46046813
27	Chronic hepatic failure (HP:0100626)	2.43004791
28	Male pseudohermaphroditism (HP:0000037)	2.42170778
29	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.40403312
30	Absent/shortened dynein arms (HP:0200106)	2.40403312
31	Congenital primary aphakia (HP:0007707)	2.34917224
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.32243482
33	Postaxial foot polydactyly (HP:0001830)	2.31801603
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.31435582
35	Congenital hepatic fibrosis (HP:0002612)	2.28192758
36	Asplenia (HP:0001746)	2.26022094
37	Congenital, generalized hypertrichosis (HP:0004540)	2.25879333
38	Nephrogenic diabetes insipidus (HP:0009806)	2.25097133
39	Tubular atrophy (HP:0000092)	2.19538881
40	Polydipsia (HP:0001959)	2.17721232
41	Abnormal drinking behavior (HP:0030082)	2.17721232
42	Furrowed tongue (HP:0000221)	2.14198813
43	Methylmalonic acidemia (HP:0002912)	2.13419576
44	Progressive cerebellar ataxia (HP:0002073)	2.10531169
45	Abnormal albumin level (HP:0012116)	2.09829951
46	Hypoalbuminemia (HP:0003073)	2.09829951
47	Large for gestational age (HP:0001520)	2.07745700
48	Renal cortical cysts (HP:0000803)	2.05784935
49	3-Methylglutaconic aciduria (HP:0003535)	2.04001062
50	Conical tooth (HP:0000698)	2.03843463
51	Genital tract atresia (HP:0001827)	2.03758864
52	Mitochondrial inheritance (HP:0001427)	2.03245512
53	Pachygyria (HP:0001302)	2.02447999
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.01785781
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01785781
56	Postaxial hand polydactyly (HP:0001162)	2.01107579
57	Vaginal atresia (HP:0000148)	2.01054826
58	Methylmalonic aciduria (HP:0012120)	2.00760402
59	Inability to walk (HP:0002540)	2.00133875
60	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98479507
61	Hypoplastic iliac wings (HP:0002866)	1.96141485
62	Concave nail (HP:0001598)	1.94375977
63	Hepatocellular necrosis (HP:0001404)	1.93750232
64	Small hand (HP:0200055)	1.93531562
65	Abnormality of the renal collecting system (HP:0004742)	1.92817148
66	Bile duct proliferation (HP:0001408)	1.91593575
67	Abnormal biliary tract physiology (HP:0012439)	1.91593575
68	Abnormality of DNA repair (HP:0003254)	1.90893371
69	Poor coordination (HP:0002370)	1.90879834
70	Lissencephaly (HP:0001339)	1.90381468
71	Optic disc pallor (HP:0000543)	1.88494884
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88401866
73	Genetic anticipation (HP:0003743)	1.87579013
74	Absent thumb (HP:0009777)	1.86319252
75	Hyperalaninemia (HP:0003348)	1.85721485
76	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85721485
77	Abnormality of alanine metabolism (HP:0010916)	1.85721485
78	Optic nerve hypoplasia (HP:0000609)	1.85717005
79	Increased CSF lactate (HP:0002490)	1.85632436
80	Colon cancer (HP:0003003)	1.85028863
81	Polyuria (HP:0000103)	1.84551111
82	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84534742
83	Hypoproteinemia (HP:0003075)	1.84393105
84	Gaze-evoked nystagmus (HP:0000640)	1.82789648
85	Abnormality of the pons (HP:0007361)	1.78985191
86	Abnormal ciliary motility (HP:0012262)	1.77897961
87	Broad-based gait (HP:0002136)	1.77858423
88	Hypothermia (HP:0002045)	1.76687858
89	Hypoplasia of the pons (HP:0012110)	1.73601945
90	Chorioretinal atrophy (HP:0000533)	1.72278255
91	Absent speech (HP:0001344)	1.71687893
92	Oligohydramnios (HP:0001562)	1.71248626
93	Preaxial hand polydactyly (HP:0001177)	1.71153572
94	Bony spicule pigmentary retinopathy (HP:0007737)	1.71006690
95	Abnormal number of erythroid precursors (HP:0012131)	1.70734767
96	Ectopic kidney (HP:0000086)	1.70029700
97	Acute necrotizing encephalopathy (HP:0006965)	1.69084465
98	Hyperglycinemia (HP:0002154)	1.68121792
99	Hepatic necrosis (HP:0002605)	1.67979574
100	Constricted visual fields (HP:0001133)	1.67867507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.21817480
2	ZAK	3.80849151
3	ADRBK2	3.40382072
4	GRK1	3.07967501
5	NUAK1	2.90389516
6	TLK1	2.81958375
7	TXK	2.61867852
8	BCKDK	2.44617515
9	TAOK3	2.40227334
10	WNK4	2.36667458
11	BMPR1B	2.24229738
12	CASK	2.24044955
13	PINK1	2.09945011
14	MAP4K2	2.09571829
15	WNK3	2.07738080
16	ACVR1B	1.99006231
17	MAP3K4	1.73096219
18	MAPK13	1.67285798
19	INSRR	1.66331733
20	OXSR1	1.49902581
21	DAPK2	1.39160523
22	VRK1	1.28247407
23	VRK2	1.26912094
24	DYRK2	1.23205791
25	TIE1	1.22769210
26	MAP2K7	1.19443597
27	TNIK	1.17311953
28	ADRBK1	1.13107392
29	PAK3	1.12942026
30	STK39	1.12763253
31	NME1	1.09919739
32	MARK1	1.09672495
33	MAPK15	1.08007470
34	PRKCG	1.06062769
35	CAMKK2	0.97722454
36	GRK7	0.97138854
37	PNCK	0.94675244
38	CSNK1G2	0.94532582
39	PHKG2	0.94199322
40	PHKG1	0.94199322
41	MUSK	0.91639737
42	PRKCE	0.87266235
43	PRKCQ	0.86396471
44	CSNK1G3	0.86072447
45	MST4	0.85562875
46	NTRK2	0.81552932
47	TEC	0.79838158
48	CSNK1G1	0.79332160
49	CSNK1A1L	0.79324806
50	NTRK3	0.79028526
51	PIK3CA	0.78368188
52	IKBKB	0.78223555
53	ITK	0.74820207
54	EIF2AK3	0.73207476
55	PLK2	0.66833656
56	CDK19	0.65744454
57	EPHA4	0.64809911
58	PTK2B	0.61833606
59	GRK5	0.61249181
60	CAMK2A	0.60375407
61	TRIM28	0.58318331
62	MAP2K6	0.56880008
63	STK38L	0.56394652
64	PRKCI	0.54376588
65	ERBB3	0.53620888
66	PRKACA	0.53000590
67	TNK2	0.51341263
68	RPS6KA5	0.51319255
69	TAF1	0.51253995
70	LATS1	0.50118364
71	MKNK2	0.50024299
72	AKT3	0.49148289
73	PKN1	0.48405783
74	EPHA3	0.47287252
75	MAPKAPK5	0.46841423
76	KIT	0.46082289
77	CSNK1A1	0.45581152
78	CAMK1	0.45537668
79	KDR	0.45258821
80	TGFBR1	0.44050042
81	PRKCZ	0.43994178
82	IRAK1	0.42651388
83	MAP2K2	0.42046691
84	STK11	0.41673402
85	CHEK2	0.41467051
86	EIF2AK2	0.39823794
87	SYK	0.38909487
88	PRKCA	0.38838757
89	MAP3K7	0.37260837
90	CSNK1D	0.37011825
91	PRKCH	0.35239642
92	CHUK	0.34190196
93	OBSCN	0.34084409
94	ABL1	0.33385977
95	NLK	0.33352150
96	FGFR2	0.32917229
97	MAPKAPK3	0.32618955
98	DYRK3	0.31397496
99	ERBB2	0.29656007
100	IKBKE	0.29001681

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.94747768
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78919824
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.44765784
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.33919597
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.27369638
6	Nicotine addiction_Homo sapiens_hsa05033	2.16788836
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.14905773
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.12054916
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.07880166
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.07692824
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.05918710
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.00851290
13	Butanoate metabolism_Homo sapiens_hsa00650	1.83721377
14	Parkinsons disease_Homo sapiens_hsa05012	1.82272424
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.76234776
16	Homologous recombination_Homo sapiens_hsa03440	1.74441041
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.63312014
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.62791344
19	Olfactory transduction_Homo sapiens_hsa04740	1.61209459
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.59004464
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.57811003
22	Protein export_Homo sapiens_hsa03060	1.53110918
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51834387
24	Propanoate metabolism_Homo sapiens_hsa00640	1.50408538
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.46424433
26	RNA polymerase_Homo sapiens_hsa03020	1.45303028
27	Morphine addiction_Homo sapiens_hsa05032	1.43826131
28	Taste transduction_Homo sapiens_hsa04742	1.38856027
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.37803064
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36899276
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.34341701
32	Caffeine metabolism_Homo sapiens_hsa00232	1.32712353
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32309788
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31571736
35	Alzheimers disease_Homo sapiens_hsa05010	1.29945046
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26745392
37	Insulin secretion_Homo sapiens_hsa04911	1.26472051
38	Peroxisome_Homo sapiens_hsa04146	1.19652169
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.16862248
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15762508
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.12699990
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12205872
43	GABAergic synapse_Homo sapiens_hsa04727	1.12023442
44	Huntingtons disease_Homo sapiens_hsa05016	1.10306133
45	Retinol metabolism_Homo sapiens_hsa00830	1.09923015
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99692819
47	Circadian entrainment_Homo sapiens_hsa04713	0.98631026
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97915722
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97810496
50	ABC transporters_Homo sapiens_hsa02010	0.96705229
51	Serotonergic synapse_Homo sapiens_hsa04726	0.96624445
52	Regulation of autophagy_Homo sapiens_hsa04140	0.95783786
53	RNA degradation_Homo sapiens_hsa03018	0.94756441
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93875879
55	Basal transcription factors_Homo sapiens_hsa03022	0.93383735
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.89994859
57	One carbon pool by folate_Homo sapiens_hsa00670	0.88596958
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87648640
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84341356
60	Asthma_Homo sapiens_hsa05310	0.84337615
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.80838538
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.79221197
63	Salivary secretion_Homo sapiens_hsa04970	0.77157205
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76551615
65	Graft-versus-host disease_Homo sapiens_hsa05332	0.76174339
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75929209
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73740731
68	Ribosome_Homo sapiens_hsa03010	0.70728229
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.67842362
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.66442308
71	Sulfur metabolism_Homo sapiens_hsa00920	0.64633138
72	Histidine metabolism_Homo sapiens_hsa00340	0.63163389
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.61143287
74	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.61004928
75	Proteasome_Homo sapiens_hsa03050	0.60972095
76	Purine metabolism_Homo sapiens_hsa00230	0.60084335
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58842762
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58762589
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58504931
80	Allograft rejection_Homo sapiens_hsa05330	0.58192639
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57852441
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.56232205
83	Metabolic pathways_Homo sapiens_hsa01100	0.54222935
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53302864
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52623044
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51309389
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51233795
88	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51001053
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.50499369
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50406764
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46405575
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44872620
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44856863
94	Amphetamine addiction_Homo sapiens_hsa05031	0.44467248
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44069165
96	Alcoholism_Homo sapiens_hsa05034	0.43866737
97	Cholinergic synapse_Homo sapiens_hsa04725	0.41298200
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.39078449
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.38329218
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37435581

KIAA1024L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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