KIAA1033

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.19814752
2positive regulation of gamma-delta T cell activation (GO:0046645)4.80746785
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.79044513
4cellular response to ethanol (GO:0071361)4.73394824
5cellular extravasation (GO:0045123)4.17548723
6positive regulation by symbiont of host defense response (GO:0052509)4.09804286
7modulation by symbiont of host defense response (GO:0052031)4.09804286
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09804286
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09804286
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.09804286
11modulation by symbiont of host immune response (GO:0052553)4.09804286
12neutrophil activation involved in immune response (GO:0002283)4.05672419
13regulation of B cell receptor signaling pathway (GO:0050855)4.03069993
14detection of external biotic stimulus (GO:0098581)4.02925050
15detection of other organism (GO:0098543)4.02853168
16macrophage activation involved in immune response (GO:0002281)4.01170607
17response to peptidoglycan (GO:0032494)3.94605146
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.93675206
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.87367309
20regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.85583219
21regulation of interferon-beta biosynthetic process (GO:0045357)3.83010701
22microglial cell activation (GO:0001774)3.72558332
23B cell receptor signaling pathway (GO:0050853)3.65876968
24negative regulation of interleukin-12 production (GO:0032695)3.59530495
25positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.58962880
26positive regulation of interferon-alpha production (GO:0032727)3.58574367
27production of molecular mediator involved in inflammatory response (GO:0002532)3.58116925
28macrophage activation (GO:0042116)3.55060435
29detection of biotic stimulus (GO:0009595)3.49572324
30regulation of interferon-alpha production (GO:0032647)3.46425070
31positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.43692032
32iron ion import (GO:0097286)3.27075663
33detection of bacterium (GO:0016045)3.26481135
34negative regulation of cell killing (GO:0031342)3.21547670
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.21547670
36response to host immune response (GO:0052572)3.17436324
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17436324
38T-helper 1 type immune response (GO:0042088)3.13731574
39regulation of gamma-delta T cell activation (GO:0046643)3.13228158
40neutrophil mediated immunity (GO:0002446)3.11917047
41monoubiquitinated protein deubiquitination (GO:0035520)3.09413739
42immunoglobulin mediated immune response (GO:0016064)3.09275554
43antigen processing and presentation of endogenous antigen (GO:0019883)3.08310466
44positive regulation of interferon-beta production (GO:0032728)3.06362102
45negative regulation of B cell proliferation (GO:0030889)3.01009657
46response to hydroperoxide (GO:0033194)2.99849373
47hepatocyte apoptotic process (GO:0097284)2.98955391
48response to host (GO:0075136)2.98762287
49response to host defenses (GO:0052200)2.98762287
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.98762287
51regulation of macrophage cytokine production (GO:0010935)2.96748340
52myeloid cell activation involved in immune response (GO:0002275)2.95330670
53positive regulation of macrophage cytokine production (GO:0060907)2.93818039
54B cell proliferation (GO:0042100)2.91317718
55positive regulation of toll-like receptor signaling pathway (GO:0034123)2.87375051
56positive regulation of B cell differentiation (GO:0045579)2.80906733
57interferon-gamma-mediated signaling pathway (GO:0060333)2.77845907
58regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.76379854
59I-kappaB phosphorylation (GO:0007252)2.75591031
60regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.73236657
61regulation of mast cell activation (GO:0033003)2.72790806
62response to muramyl dipeptide (GO:0032495)2.72081810
63B cell mediated immunity (GO:0019724)2.71855646
64positive regulation of cellular amide metabolic process (GO:0034250)2.70094663
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.68909197
66myeloid leukocyte mediated immunity (GO:0002444)2.68527419
67histone H3-K36 demethylation (GO:0070544)2.67452435
68negative regulation of T cell mediated immunity (GO:0002710)2.67150990
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66408975
70regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65168948
71neutrophil activation (GO:0042119)2.64064425
72regulation of gamma-delta T cell differentiation (GO:0045586)2.63619712
73positive regulation of mast cell activation (GO:0033005)2.62464040
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62225563
75cellular response to type I interferon (GO:0071357)2.61836854
76type I interferon signaling pathway (GO:0060337)2.61836854
77response to type I interferon (GO:0034340)2.60572134
78germinal center formation (GO:0002467)2.59474148
79interleukin-6-mediated signaling pathway (GO:0070102)2.59388473
80negative regulation of T-helper cell differentiation (GO:0045623)2.57658124
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.57658124
82regulation of B cell differentiation (GO:0045577)2.57008561
83positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56287884
84regulation of interleukin-8 biosynthetic process (GO:0045414)2.53216231
85nuclear pore complex assembly (GO:0051292)2.52455720
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52010929
87respiratory burst (GO:0045730)2.51809947
88regulation of interferon-beta production (GO:0032648)2.51038890
89histone mRNA catabolic process (GO:0071044)2.49814870
90dendritic cell migration (GO:0036336)2.49571180
91adaptive immune response (GO:0002250)2.48687645
92regulation of T-helper 1 cell differentiation (GO:0045625)2.48540436
93response to interferon-alpha (GO:0035455)2.48113782
94negative regulation of interleukin-17 production (GO:0032700)2.47198918
95positive regulation of leukocyte degranulation (GO:0043302)2.45143973
96T cell migration (GO:0072678)2.44195515
97myeloid leukocyte activation (GO:0002274)2.44036559
98protein targeting to lysosome (GO:0006622)2.43127168
99establishment of protein localization to vacuole (GO:0072666)2.43127168
100protein targeting to vacuole (GO:0006623)2.43127168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70698650
2* IRF8_22096565_ChIP-ChIP_GC-B_Human4.24998843
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.61353979
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.98540159
5GATA1_22025678_ChIP-Seq_K562_Human2.97412527
6Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.84225040
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.71913836
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68403648
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67463335
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.62084418
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.56612753
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.54588138
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53394351
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45239189
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24701943
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19910294
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17704190
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09315718
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.08967071
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08292405
21RUNX_20019798_ChIP-Seq_JUKART_Human1.91137846
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88862704
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.84255813
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.78057757
25VDR_24787735_ChIP-Seq_THP-1_Human1.75576232
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66718871
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65528193
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62662109
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60833777
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60042266
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59270369
32MYB_26560356_Chip-Seq_TH2_Human1.56604263
33* SPI1_23547873_ChIP-Seq_NB4_Human1.56365152
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.54154769
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51846336
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47882100
37BRD4_25478319_ChIP-Seq_HGPS_Human1.46351554
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42143492
39PU_27001747_Chip-Seq_BMDM_Mouse1.40456323
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.38985284
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37985426
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32229147
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31860634
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28537617
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28537617
46MYB_26560356_Chip-Seq_TH1_Human1.27449219
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25907298
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25717805
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23803785
50TAF15_26573619_Chip-Seq_HEK293_Human1.22450248
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22402794
52GATA3_26560356_Chip-Seq_TH2_Human1.21899906
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21683323
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21368690
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.18325692
56SCL_19346495_ChIP-Seq_HPC-7_Human1.18158272
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17540515
58CJUN_26792858_Chip-Seq_BT549_Human1.16854612
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16729898
60* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16515337
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16149886
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15207202
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15150829
64GATA3_27048872_Chip-Seq_THYMUS_Human1.14918957
65* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13757067
66SPI1_23127762_ChIP-Seq_K562_Human1.12863485
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12339706
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12167329
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11156534
70CDX2_22108803_ChIP-Seq_LS180_Human1.10981165
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09970911
72TP53_16413492_ChIP-PET_HCT116_Human1.09875044
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.09160830
74OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08731438
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08632597
76TP63_23658742_ChIP-Seq_EP156T_Human1.08411916
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.07951086
78ER_23166858_ChIP-Seq_MCF-7_Human1.04561231
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.04353204
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04285351
81P300_19829295_ChIP-Seq_ESCs_Human1.03613954
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.02983752
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02861903
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.02363116
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01859755
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01859755
87EWS_26573619_Chip-Seq_HEK293_Human1.01798572
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01793067
89SALL4_22934838_ChIP-ChIP_CD34+_Human1.01252299
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.00852406
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00791594
92ELK1_19687146_ChIP-ChIP_HELA_Human1.00401962
93TFEB_21752829_ChIP-Seq_HELA_Human1.00030603
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99889004
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.97391678
96STAT3_23295773_ChIP-Seq_U87_Human0.96019165
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95847322
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95671662
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.95369061
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.94700190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.58527304
2MP0003724_increased_susceptibility_to3.56070814
3MP0000569_abnormal_digit_pigmentation3.37006118
4MP0006054_spinal_hemorrhage3.14796761
5MP0003303_peritoneal_inflammation2.97387433
6MP0003300_gastrointestinal_ulcer2.46814000
7MP0002166_altered_tumor_susceptibility2.42686230
8MP0008057_abnormal_DNA_replication2.42054932
9MP0008260_abnormal_autophagy2.30456586
10MP0002419_abnormal_innate_immunity2.21651364
11MP0009785_altered_susceptibility_to2.17895241
12MP0001800_abnormal_humoral_immune2.14278642
13MP0010352_gastrointestinal_tract_polyps2.10492338
14MP0003828_pulmonary_edema2.09666515
15MP0000685_abnormal_immune_system2.07650225
16MP0010234_abnormal_vibrissa_follicle2.01067626
17MP0006082_CNS_inflammation1.95545106
18MP0005000_abnormal_immune_tolerance1.93672872
19MP0003191_abnormal_cellular_cholesterol1.92425361
20MP0002452_abnormal_antigen_presenting1.91686011
21MP0003436_decreased_susceptibility_to1.88863256
22MP0005387_immune_system_phenotype1.87879373
23MP0001790_abnormal_immune_system1.87879373
24MP0002009_preneoplasia1.79565985
25MP0002006_tumorigenesis1.76058846
26MP0002148_abnormal_hypersensitivity_rea1.75950428
27MP0002723_abnormal_immune_serum1.74851408
28MP0004883_abnormal_blood_vessel1.72347403
29MP0003172_abnormal_lysosome_physiology1.72042977
30MP0005025_abnormal_response_to1.65017396
31MP0002420_abnormal_adaptive_immunity1.62759082
32MP0003091_abnormal_cell_migration1.61590970
33MP0003763_abnormal_thymus_physiology1.61155268
34MP0001819_abnormal_immune_cell1.60979515
35MP0002396_abnormal_hematopoietic_system1.59730039
36MP0000465_gastrointestinal_hemorrhage1.59717905
37MP0005671_abnormal_response_to1.58974498
38MP0005464_abnormal_platelet_physiology1.58959117
39MP0003656_abnormal_erythrocyte_physiolo1.51379829
40MP0005397_hematopoietic_system_phenotyp1.47736319
41MP0001545_abnormal_hematopoietic_system1.47736319
42MP0004808_abnormal_hematopoietic_stem1.45531266
43MP0005164_abnormal_response_to1.41531099
44MP0005451_abnormal_body_composition1.39254534
45MP0002405_respiratory_system_inflammati1.38934504
46MP0004947_skin_inflammation1.38467028
47MP0003950_abnormal_plasma_membrane1.37664139
48MP0002398_abnormal_bone_marrow1.31820216
49MP0002138_abnormal_hepatobiliary_system1.29513337
50MP0001845_abnormal_inflammatory_respons1.27482127
51MP0000716_abnormal_immune_system1.26227503
52MP0010155_abnormal_intestine_physiology1.25805126
53MP0003221_abnormal_cardiomyocyte_apopto1.25562526
54MP0001533_abnormal_skeleton_physiology1.21863490
55MP0002998_abnormal_bone_remodeling1.20135872
56MP0001853_heart_inflammation1.19282647
57MP0001851_eye_inflammation1.19132555
58MP0000689_abnormal_spleen_morphology1.18948260
59MP0009764_decreased_sensitivity_to1.16974121
60MP0003448_altered_tumor_morphology1.14345489
61MP0000015_abnormal_ear_pigmentation1.14291843
62MP0003252_abnormal_bile_duct1.14084292
63MP0003183_abnormal_peptide_metabolism1.09044416
64MP0005310_abnormal_salivary_gland1.08832784
65MP0004484_altered_response_of1.07341262
66MP0010678_abnormal_skin_adnexa1.07338566
67MP0001915_intracranial_hemorrhage1.06935697
68MP0002722_abnormal_immune_system1.06305363
69MP0002877_abnormal_melanocyte_morpholog1.04395094
70MP0003690_abnormal_glial_cell1.04192505
71MP0000371_diluted_coat_color1.04091051
72MP0005058_abnormal_lysosome_morphology1.01364295
73MP0008469_abnormal_protein_level1.00635669
74MP0003566_abnormal_cell_adhesion0.99555772
75MP0000604_amyloidosis0.97626555
76MP0002429_abnormal_blood_cell0.96500122
77MP0009278_abnormal_bone_marrow0.96316748
78MP0002332_abnormal_exercise_endurance0.94905799
79MP0000858_altered_metastatic_potential0.94609722
80MP0003045_fibrosis0.90813850
81MP0000249_abnormal_blood_vessel0.86545380
82MP0008004_abnormal_stomach_pH0.86052012
83MP0003868_abnormal_feces_composition0.85235055
84MP0005174_abnormal_tail_pigmentation0.84817999
85MP0003075_altered_response_to0.83208715
86MP0008438_abnormal_cutaneous_collagen0.82886895
87MP0002132_abnormal_respiratory_system0.82011152
88MP0002254_reproductive_system_inflammat0.80941881
89MP0003195_calcinosis0.80404500
90MP0004084_abnormal_cardiac_muscle0.80238954
91MP0003787_abnormal_imprinting0.79702945
92MP0000343_altered_response_to0.79311650
93MP0005075_abnormal_melanosome_morpholog0.78724784
94MP0005388_respiratory_system_phenotype0.76539193
95MP0002133_abnormal_respiratory_system0.76539193
96MP0008877_abnormal_DNA_methylation0.76079417
97MP0005621_abnormal_cell_physiology0.74161575
98MP0000703_abnormal_thymus_morphology0.73139752
99MP0010307_abnormal_tumor_latency0.71387578
100MP0001958_emphysema0.70203031

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.19203321
2Abnormality of T cell number (HP:0011839)4.74282346
3Recurrent bacterial skin infections (HP:0005406)4.61048378
4Recurrent abscess formation (HP:0002722)4.06722542
5Hematochezia (HP:0002573)3.85572021
6Eczematoid dermatitis (HP:0000976)3.78261364
7Optic neuritis (HP:0100653)3.65592894
8Retrobulbar optic neuritis (HP:0100654)3.65592894
9Spontaneous hematomas (HP:0007420)3.57229541
10Orchitis (HP:0100796)3.42108448
11Recurrent gram-negative bacterial infections (HP:0005420)3.41013844
12Recurrent fungal infections (HP:0002841)3.36767328
13Myositis (HP:0100614)3.32190016
14Papillary thyroid carcinoma (HP:0002895)3.30359069
15Recurrent viral infections (HP:0004429)3.27446424
16Abnormality of macrophages (HP:0004311)3.18174315
17Thyroiditis (HP:0100646)3.17525654
18Recurrent skin infections (HP:0001581)3.06355901
19Abnormality of B cell number (HP:0010975)3.04830748
20Abnormality of glycolipid metabolism (HP:0010969)2.97968136
21Abnormality of liposaccharide metabolism (HP:0010968)2.97968136
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.97968136
23B lymphocytopenia (HP:0010976)2.92795848
24Hypoplasia of the thymus (HP:0000778)2.91499773
25Abnormality of the vasculature of the conjunctiva (HP:0008054)2.89523365
26Chronic mucocutaneous candidiasis (HP:0002728)2.86821597
27Recurrent cutaneous fungal infections (HP:0011370)2.86821597
28Myocardial infarction (HP:0001658)2.77056447
29Keratoconjunctivitis sicca (HP:0001097)2.75895741
30Meningitis (HP:0001287)2.75201510
31Gingival bleeding (HP:0000225)2.71722424
32Gastrointestinal infarctions (HP:0005244)2.71185096
33Gingivitis (HP:0000230)2.65856276
34Panhypogammaglobulinemia (HP:0003139)2.65260973
35Conjunctival telangiectasia (HP:0000524)2.64066129
36Abnormality of T cells (HP:0002843)2.61094865
37Arterial thrombosis (HP:0004420)2.59790961
38Hemoptysis (HP:0002105)2.59445135
39Osteomyelitis (HP:0002754)2.58383439
40Subacute progressive viral hepatitis (HP:0006572)2.57362263
41Mediastinal lymphadenopathy (HP:0100721)2.57024868
42Stomatitis (HP:0010280)2.56468870
43Eosinophilia (HP:0001880)2.52235382
44Pulmonary infiltrates (HP:0002113)2.49440915
45Keratoconjunctivitis (HP:0001096)2.48500508
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.42791837
47Leukocytosis (HP:0001974)2.42600229
48Peritonitis (HP:0002586)2.40649468
49Vasculitis (HP:0002633)2.40079075
50Cellulitis (HP:0100658)2.37827836
51Recurrent bronchitis (HP:0002837)2.36559346
52Periodontitis (HP:0000704)2.34401434
53Thyroid carcinoma (HP:0002890)2.33141823
54Chronic diarrhea (HP:0002028)2.32591996
55Chest pain (HP:0100749)2.32082037
56Absent frontal sinuses (HP:0002688)2.28867284
57Fatigue (HP:0012378)2.28010108
58Autoimmune hemolytic anemia (HP:0001890)2.25449569
59Disinhibition (HP:0000734)2.21369516
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20428349
61Granulocytopenia (HP:0001913)2.15483023
62Viral hepatitis (HP:0006562)2.14994259
63Pulmonary embolism (HP:0002204)2.14373775
64Spondylolisthesis (HP:0003302)2.11439595
65Mucosal telangiectasiae (HP:0100579)2.09169476
66Urticaria (HP:0001025)2.09166236
67Lower limb hyperreflexia (HP:0002395)2.08503105
68Elevated erythrocyte sedimentation rate (HP:0003565)2.03224794
69Amaurosis fugax (HP:0100576)2.01494415
70Acute myeloid leukemia (HP:0004808)2.00568454
71Encephalitis (HP:0002383)1.97803877
72Agammaglobulinemia (HP:0004432)1.96368568
73Abnormality of eosinophils (HP:0001879)1.95826858
74Loss of speech (HP:0002371)1.95434057
75Syringomyelia (HP:0003396)1.93448563
76Spinal cord lesions (HP:0100561)1.93448563
77Epistaxis (HP:0000421)1.93253827
78Thickened calvaria (HP:0002684)1.92326721
79Increased CSF protein (HP:0002922)1.91082513
80Combined immunodeficiency (HP:0005387)1.88730928
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.86433895
82Severe combined immunodeficiency (HP:0004430)1.86329859
83Inflammation of the large intestine (HP:0002037)1.83080894
84Albinism (HP:0001022)1.82656768
85Thrombocytosis (HP:0001894)1.82649673
86Sepsis (HP:0100806)1.82062792
87Stomach cancer (HP:0012126)1.81378242
88Hypoproteinemia (HP:0003075)1.81018271
89Osteolytic defects of the hand bones (HP:0009699)1.80005309
90Osteolytic defects of the phalanges of the hand (HP:0009771)1.80005309
91Recurrent pneumonia (HP:0006532)1.79881838
92Esophageal varix (HP:0002040)1.79191122
93Colitis (HP:0002583)1.78704815
94Gangrene (HP:0100758)1.78332896
95Scanning speech (HP:0002168)1.78016606
96Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77203511
97Abnormal platelet volume (HP:0011876)1.76092111
98Curly hair (HP:0002212)1.76038076
99IgA deficiency (HP:0002720)1.75891992
100IgM deficiency (HP:0002850)1.73476946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK2.97907542
2BLK2.97288202
3MAP3K142.89058613
4TYK22.59687089
5PIK3CG2.38029115
6ACVR1B2.21859873
7EIF2AK32.21533975
8BMPR22.17110562
9TEC2.16677491
10JAK12.16116977
11TAOK32.05983880
12TGFBR21.97328712
13JAK31.95971627
14MAP2K31.95432188
15IRAK41.91364768
16CSK1.90299229
17RIPK41.85259860
18NEK91.76857825
19TRPM71.72241831
20FGFR31.67896264
21IKBKE1.59347273
22STK241.57633826
23FES1.57143397
24MAP3K131.56908076
25CDK61.55295578
26KIT1.54815341
27YES11.51940015
28BTK1.49999622
29ZAP701.42484730
30FGR1.42077745
31STK38L1.36599004
32SYK1.35653512
33NLK1.34286159
34TIE11.34079125
35MAP3K61.30086448
36BRD41.29953143
37HCK1.24633641
38ERBB31.23431754
39MAP3K21.18198704
40IRAK11.17443561
41JAK21.13060334
42LYN1.09897767
43MAP4K11.07066130
44CSF1R1.06820441
45ITK1.01758841
46STK101.00887787
47SGK20.97947079
48AKT30.96017213
49LCK0.94904657
50SGK30.94535421
51CAMKK20.92101246
52EGFR0.91758657
53TXK0.89808490
54MAP3K100.89408712
55TBK10.88646487
56SCYL20.86270704
57MELK0.85101768
58PBK0.84460860
59STK30.83843870
60MST40.80921855
61TGFBR10.79623981
62BMPR1B0.77922443
63IKBKB0.76710941
64FER0.74527297
65MAP3K50.73715766
66IRAK20.72083525
67MATK0.71013163
68NEK60.67287442
69MAPK70.67174127
70PLK20.67118936
71GRK70.66762314
72LATS10.66136227
73MARK30.65701246
74PTK2B0.60865641
75MAP3K30.59838371
76BRSK20.57550890
77WNK10.57316844
78NUAK10.56046435
79PDGFRB0.55620422
80ABL10.55492277
81KSR10.55064712
82OXSR10.51943670
83IGF1R0.50728207
84MAP3K10.49544428
85CAMK1G0.47555880
86GRK60.46266454
87PIM10.46187529
88RAF10.43764922
89PDK10.43704724
90PRPF4B0.43699529
91RPS6KB10.43284627
92FGFR20.42294879
93MOS0.42246626
94MAP3K120.38545704
95CHUK0.38424625
96INSR0.38108584
97CDK120.34890214
98CLK10.32724581
99PRKCQ0.31614382
100KSR20.31445212

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.84668575
2Staphylococcus aureus infection_Homo sapiens_hsa051502.37535600
3Osteoclast differentiation_Homo sapiens_hsa043802.21823320
4Allograft rejection_Homo sapiens_hsa053302.13865688
5B cell receptor signaling pathway_Homo sapiens_hsa046622.11428861
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10089403
7Tuberculosis_Homo sapiens_hsa051522.02238057
8Asthma_Homo sapiens_hsa053102.01297021
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.98991475
10Graft-versus-host disease_Homo sapiens_hsa053321.93065700
11Autoimmune thyroid disease_Homo sapiens_hsa053201.91313015
12Toxoplasmosis_Homo sapiens_hsa051451.87435291
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85103596
14Legionellosis_Homo sapiens_hsa051341.76559924
15Type I diabetes mellitus_Homo sapiens_hsa049401.76380376
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69691167
17Influenza A_Homo sapiens_hsa051641.68997404
18Measles_Homo sapiens_hsa051621.68478941
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.65307352
20Hematopoietic cell lineage_Homo sapiens_hsa046401.58654810
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.58389654
22Malaria_Homo sapiens_hsa051441.45633213
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.38813872
24Viral myocarditis_Homo sapiens_hsa054161.37836302
25Rheumatoid arthritis_Homo sapiens_hsa053231.34665883
26Phagosome_Homo sapiens_hsa041451.31128394
27Antigen processing and presentation_Homo sapiens_hsa046121.30823945
28Herpes simplex infection_Homo sapiens_hsa051681.29776114
29TNF signaling pathway_Homo sapiens_hsa046681.29098884
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28459471
31Non-homologous end-joining_Homo sapiens_hsa034501.27570400
32Platelet activation_Homo sapiens_hsa046111.27542143
33Lysosome_Homo sapiens_hsa041421.26474008
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24294873
35Dorso-ventral axis formation_Homo sapiens_hsa043201.21534350
36Hepatitis B_Homo sapiens_hsa051611.21390767
37Other glycan degradation_Homo sapiens_hsa005111.19194733
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.18342536
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17849209
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17172036
41Pertussis_Homo sapiens_hsa051331.14898282
42Primary immunodeficiency_Homo sapiens_hsa053401.14797562
43Pancreatic cancer_Homo sapiens_hsa052121.11385906
44T cell receptor signaling pathway_Homo sapiens_hsa046601.10767788
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09965758
46FoxO signaling pathway_Homo sapiens_hsa040681.03792019
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03572919
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03268884
49Hepatitis C_Homo sapiens_hsa051601.02911975
50Chemokine signaling pathway_Homo sapiens_hsa040621.02022126
51Renal cell carcinoma_Homo sapiens_hsa052110.99652715
52Inositol phosphate metabolism_Homo sapiens_hsa005620.98606278
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97332158
54Glycosaminoglycan degradation_Homo sapiens_hsa005310.96145884
55Chronic myeloid leukemia_Homo sapiens_hsa052200.94212790
56Prolactin signaling pathway_Homo sapiens_hsa049170.93401776
57Non-small cell lung cancer_Homo sapiens_hsa052230.91203738
58Shigellosis_Homo sapiens_hsa051310.89096286
59Acute myeloid leukemia_Homo sapiens_hsa052210.88286500
60African trypanosomiasis_Homo sapiens_hsa051430.84357890
61Amoebiasis_Homo sapiens_hsa051460.81330099
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76680223
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.76426946
64Proteoglycans in cancer_Homo sapiens_hsa052050.75983359
65Small cell lung cancer_Homo sapiens_hsa052220.71030059
66Apoptosis_Homo sapiens_hsa042100.70837524
67Salmonella infection_Homo sapiens_hsa051320.69932563
68Prostate cancer_Homo sapiens_hsa052150.68294098
69HIF-1 signaling pathway_Homo sapiens_hsa040660.67168702
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66183625
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.65424090
72mTOR signaling pathway_Homo sapiens_hsa041500.65382983
73Adherens junction_Homo sapiens_hsa045200.65338163
74Complement and coagulation cascades_Homo sapiens_hsa046100.62889408
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61281814
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60631764
77Viral carcinogenesis_Homo sapiens_hsa052030.59420290
78Focal adhesion_Homo sapiens_hsa045100.59077058
79Endometrial cancer_Homo sapiens_hsa052130.57394008
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55952825
81Colorectal cancer_Homo sapiens_hsa052100.55286087
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54438214
83MicroRNAs in cancer_Homo sapiens_hsa052060.52724541
84Systemic lupus erythematosus_Homo sapiens_hsa053220.52701000
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52478199
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51041052
87Renin-angiotensin system_Homo sapiens_hsa046140.50641500
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48609392
89p53 signaling pathway_Homo sapiens_hsa041150.48359382
90Choline metabolism in cancer_Homo sapiens_hsa052310.47601776
91Sphingolipid metabolism_Homo sapiens_hsa006000.47235577
92HTLV-I infection_Homo sapiens_hsa051660.47148644
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46974168
94Insulin resistance_Homo sapiens_hsa049310.45513522
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43857803
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.42375077
97Epstein-Barr virus infection_Homo sapiens_hsa051690.40354103
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35745724
99Glioma_Homo sapiens_hsa052140.34849226
100VEGF signaling pathway_Homo sapiens_hsa043700.34223039

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