KIAA1107

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.21032023
2behavioral response to nicotine (GO:0035095)4.96847333
3protein localization to synapse (GO:0035418)4.77246822
4positive regulation of action potential (GO:0045760)4.54438328
5nucleobase catabolic process (GO:0046113)4.23401303
6presynaptic membrane assembly (GO:0097105)4.22858894
7regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.09274077
8axonal fasciculation (GO:0007413)4.00488985
9glycerophospholipid catabolic process (GO:0046475)4.00323674
10auditory behavior (GO:0031223)3.99335050
11neuron cell-cell adhesion (GO:0007158)3.91955632
12neuron recognition (GO:0008038)3.91554457
13neuronal action potential propagation (GO:0019227)3.90098634
14neuronal action potential (GO:0019228)3.88783112
15adaptation of signaling pathway (GO:0023058)3.83237570
16synapse assembly (GO:0007416)3.82248880
17regulation of action potential (GO:0098900)3.79473304
18presynaptic membrane organization (GO:0097090)3.75935095
19startle response (GO:0001964)3.75861974
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.72546556
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70396093
22mechanosensory behavior (GO:0007638)3.68897823
23exploration behavior (GO:0035640)3.63929016
24gamma-aminobutyric acid transport (GO:0015812)3.62795576
25glutamate receptor signaling pathway (GO:0007215)3.57153253
26detection of calcium ion (GO:0005513)3.56215768
27neurotransmitter-gated ion channel clustering (GO:0072578)3.55386081
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.52220013
29central nervous system projection neuron axonogenesis (GO:0021952)3.51492001
30postsynaptic membrane organization (GO:0001941)3.41315745
31positive regulation of growth hormone secretion (GO:0060124)3.40451648
32establishment of mitochondrion localization (GO:0051654)3.40322974
33neurofilament cytoskeleton organization (GO:0060052)3.40210950
34epithelial cell differentiation involved in kidney development (GO:0035850)3.37738755
35regulation of dopamine secretion (GO:0014059)3.35903056
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.35233939
37neuron fate determination (GO:0048664)3.31080119
38calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.25774675
39neuron-neuron synaptic transmission (GO:0007270)3.20465372
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18497348
41dendritic spine morphogenesis (GO:0060997)3.18066025
42membrane depolarization during action potential (GO:0086010)3.16668335
43regulation of synaptic transmission, glutamatergic (GO:0051966)3.14238850
44protein polyglutamylation (GO:0018095)3.10744286
45dopamine biosynthetic process (GO:0042416)3.09546509
46righting reflex (GO:0060013)3.05862672
47regulation of synapse structural plasticity (GO:0051823)3.05412458
48synaptic transmission, glutamatergic (GO:0035249)3.04126927
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03640187
50central nervous system neuron axonogenesis (GO:0021955)3.01433337
51cerebral cortex radially oriented cell migration (GO:0021799)3.01432201
52acrosome reaction (GO:0007340)2.99831098
53adult walking behavior (GO:0007628)2.99761166
54mitochondrion transport along microtubule (GO:0047497)2.94901855
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94901855
56retinal ganglion cell axon guidance (GO:0031290)2.93936974
57nerve growth factor signaling pathway (GO:0038180)2.93249248
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92644015
59dendrite morphogenesis (GO:0048813)2.92219337
60neurotransmitter secretion (GO:0007269)2.91501489
61negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89481531
62regulation of axon guidance (GO:1902667)2.88850629
63transmission of nerve impulse (GO:0019226)2.87785941
64reflex (GO:0060004)2.86266656
65response to auditory stimulus (GO:0010996)2.85904550
66cAMP-mediated signaling (GO:0019933)2.84783959
67protein localization to cilium (GO:0061512)2.84290961
68establishment of protein localization to Golgi (GO:0072600)2.82620814
69negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.79656777
70synapse organization (GO:0050808)2.79211546
71protein targeting to Golgi (GO:0000042)2.77941872
72positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.76661507
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76649705
74prepulse inhibition (GO:0060134)2.74853549
75regulation of postsynaptic membrane potential (GO:0060078)2.74679743
76response to histamine (GO:0034776)2.74583789
77membrane depolarization (GO:0051899)2.74171227
78regulation of feeding behavior (GO:0060259)2.73983565
79action potential (GO:0001508)2.73837262
80behavioral response to cocaine (GO:0048148)2.73797565
81negative regulation of axon guidance (GO:1902668)2.72762051
82regulation of vesicle fusion (GO:0031338)2.70785665
83homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.70731246
84spinal cord motor neuron differentiation (GO:0021522)2.69791270
85adult behavior (GO:0030534)2.69728001
86vocalization behavior (GO:0071625)2.69288089
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.65312910
88short-term memory (GO:0007614)2.64448065
89membrane hyperpolarization (GO:0060081)2.63728986
90synaptic transmission, cholinergic (GO:0007271)2.63683957
91regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61388872
92positive regulation of synapse assembly (GO:0051965)2.61388582
93positive regulation of gastrulation (GO:2000543)2.59876217
94regulation of growth hormone secretion (GO:0060123)2.59149392
95vesicle transport along microtubule (GO:0047496)2.58746114
96cochlea development (GO:0090102)2.58614980
97glycosphingolipid biosynthetic process (GO:0006688)2.57733490
98organelle transport along microtubule (GO:0072384)2.55710445
99retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53548267
100regulation of calcium ion-dependent exocytosis (GO:0017158)2.52019374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.02918931
2GBX2_23144817_ChIP-Seq_PC3_Human3.87657286
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.23879066
4VDR_22108803_ChIP-Seq_LS180_Human3.01443216
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86367723
6ZNF274_21170338_ChIP-Seq_K562_Hela2.68703164
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58294506
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56495598
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53878375
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.48704130
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41662476
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39088059
13TAF15_26573619_Chip-Seq_HEK293_Human2.31676716
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21858325
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14155648
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08922714
17FUS_26573619_Chip-Seq_HEK293_Human2.08475231
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.07400606
19REST_21632747_ChIP-Seq_MESCs_Mouse2.05603450
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95674624
21RNF2_27304074_Chip-Seq_NSC_Mouse1.94130985
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.94089151
23P300_19829295_ChIP-Seq_ESCs_Human1.85860799
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85618772
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84636402
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84128955
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83200331
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81712843
29IGF1R_20145208_ChIP-Seq_DFB_Human1.81458696
30SMAD4_21799915_ChIP-Seq_A2780_Human1.81211632
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77970689
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73443009
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.70725184
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.68783166
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66951330
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66050497
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64593197
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61852780
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59514659
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.58187737
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.57026265
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.56964314
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56163318
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55997640
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55930098
46ER_23166858_ChIP-Seq_MCF-7_Human1.53961355
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53298906
48EWS_26573619_Chip-Seq_HEK293_Human1.51706348
49STAT3_23295773_ChIP-Seq_U87_Human1.50949313
50AR_25329375_ChIP-Seq_VCAP_Human1.50538304
51DROSHA_22980978_ChIP-Seq_HELA_Human1.49440452
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46188244
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44565467
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44384644
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44384644
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43357471
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43357471
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43184278
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42469463
60AR_21572438_ChIP-Seq_LNCaP_Human1.41318645
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34777750
62TCF4_23295773_ChIP-Seq_U87_Human1.34452863
63RNF2_27304074_Chip-Seq_ESCs_Mouse1.32649277
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32121168
65CBP_20019798_ChIP-Seq_JUKART_Human1.32121168
66BCAT_22108803_ChIP-Seq_LS180_Human1.30823833
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29105772
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26037258
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22194096
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.22127705
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21461688
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.20498133
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20331698
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18848590
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17710226
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17229374
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17217215
78RUNX2_22187159_ChIP-Seq_PCA_Human1.16897632
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15476147
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.11927984
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.10460895
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09465969
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08504882
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07719706
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05935481
86JUN_21703547_ChIP-Seq_K562_Human1.05396928
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04453694
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03564489
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01918195
90TCF4_22108803_ChIP-Seq_LS180_Human1.01758893
91KDM2B_26808549_Chip-Seq_REH_Human1.01450820
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00313709
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.00184026
94P53_22387025_ChIP-Seq_ESCs_Mouse0.98992298
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98424642
96TP53_22573176_ChIP-Seq_HFKS_Human0.98143062
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.98142540
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98070377
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.97564095
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96504716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.50025823
2MP0004859_abnormal_synaptic_plasticity3.36630262
3MP0003787_abnormal_imprinting3.26792743
4MP0003122_maternal_imprinting3.11138407
5MP0002822_catalepsy2.89764703
6MP0002102_abnormal_ear_morphology2.74731011
7MP0009046_muscle_twitch2.71270039
8MP0002735_abnormal_chemical_nociception2.56162689
9MP0004270_analgesia2.53175528
10MP0001529_abnormal_vocalization2.49113376
11MP0003635_abnormal_synaptic_transmissio2.48710068
12MP0000778_abnormal_nervous_system2.48556923
13MP0009745_abnormal_behavioral_response2.38599748
14MP0002272_abnormal_nervous_system2.33277366
15MP0001486_abnormal_startle_reflex2.33162303
16MP0008877_abnormal_DNA_methylation2.17939840
17MP0002063_abnormal_learning/memory/cond2.15910663
18MP0002064_seizures2.11487886
19MP0001968_abnormal_touch/_nociception2.11485086
20MP0002572_abnormal_emotion/affect_behav2.04739840
21MP0003121_genomic_imprinting2.04583456
22MP0000569_abnormal_digit_pigmentation2.03188614
23MP0005423_abnormal_somatic_nervous2.02036570
24MP0005551_abnormal_eye_electrophysiolog2.01889648
25MP0006072_abnormal_retinal_apoptosis2.00634343
26MP0006276_abnormal_autonomic_nervous1.96083322
27MP0002734_abnormal_mechanical_nocicepti1.94888240
28MP0004142_abnormal_muscle_tone1.93273667
29MP0003890_abnormal_embryonic-extraembry1.86808838
30MP0005386_behavior/neurological_phenoty1.84922512
31MP0004924_abnormal_behavior1.84922512
32MP0002067_abnormal_sensory_capabilities1.82656819
33MP0002909_abnormal_adrenal_gland1.72745670
34MP0001440_abnormal_grooming_behavior1.72272491
35MP0002638_abnormal_pupillary_reflex1.71687375
36MP0002184_abnormal_innervation1.71618094
37MP0002736_abnormal_nociception_after1.71391571
38MP0003011_delayed_dark_adaptation1.69510503
39MP0000955_abnormal_spinal_cord1.68066337
40MP0001188_hyperpigmentation1.64191972
41MP0001501_abnormal_sleep_pattern1.62405268
42MP0002557_abnormal_social/conspecific_i1.62377889
43MP0004742_abnormal_vestibular_system1.61533267
44MP0001970_abnormal_pain_threshold1.59930408
45MP0001905_abnormal_dopamine_level1.59488411
46MP0001984_abnormal_olfaction1.50084008
47MP0005253_abnormal_eye_physiology1.47047648
48MP0010386_abnormal_urinary_bladder1.45356411
49MP0002733_abnormal_thermal_nociception1.45001224
50MP0002882_abnormal_neuron_morphology1.42589441
51MP0001502_abnormal_circadian_rhythm1.40851519
52MP0000631_abnormal_neuroendocrine_gland1.38388847
53MP0004811_abnormal_neuron_physiology1.33081714
54MP0001485_abnormal_pinna_reflex1.31300487
55MP0005645_abnormal_hypothalamus_physiol1.29798445
56MP0005646_abnormal_pituitary_gland1.28208960
57MP0004133_heterotaxia1.20676805
58MP0002152_abnormal_brain_morphology1.13544090
59MP0002752_abnormal_somatic_nervous1.10775507
60MP0004885_abnormal_endolymph1.09157905
61MP0002066_abnormal_motor_capabilities/c1.08977937
62MP0006292_abnormal_olfactory_placode1.04688826
63MP0003283_abnormal_digestive_organ1.03562926
64MP0003633_abnormal_nervous_system1.02515866
65MP0002751_abnormal_autonomic_nervous1.01299074
66MP0001986_abnormal_taste_sensitivity1.00603229
67MP0002234_abnormal_pharynx_morphology0.97168738
68MP0005187_abnormal_penis_morphology0.94510801
69MP0002229_neurodegeneration0.94161762
70MP0003878_abnormal_ear_physiology0.93637018
71MP0005377_hearing/vestibular/ear_phenot0.93637018
72MP0003119_abnormal_digestive_system0.93233411
73MP0002069_abnormal_eating/drinking_beha0.92858862
74MP0005410_abnormal_fertilization0.92571332
75MP0002332_abnormal_exercise_endurance0.91604770
76MP0002837_dystrophic_cardiac_calcinosis0.90851623
77MP0003195_calcinosis0.90620163
78MP0000026_abnormal_inner_ear0.90122726
79MP0003938_abnormal_ear_development0.88995995
80MP0003631_nervous_system_phenotype0.87132946
81MP0004145_abnormal_muscle_electrophysio0.86250223
82MP0005195_abnormal_posterior_eye0.84199924
83MP0003861_abnormal_nervous_system0.78649820
84MP0008569_lethality_at_weaning0.78078855
85MP0002928_abnormal_bile_duct0.77067936
86MP0004085_abnormal_heartbeat0.76497212
87MP0003698_abnormal_male_reproductive0.73608589
88MP0000049_abnormal_middle_ear0.72334947
89MP0005499_abnormal_olfactory_system0.69391258
90MP0005394_taste/olfaction_phenotype0.69391258
91MP0008872_abnormal_physiological_respon0.69192735
92MP0004043_abnormal_pH_regulation0.68305590
93MP0003137_abnormal_impulse_conducting0.66041211
94MP0001963_abnormal_hearing_physiology0.65279833
95MP0000516_abnormal_urinary_system0.62316612
96MP0005367_renal/urinary_system_phenotyp0.62316612
97MP0010770_preweaning_lethality0.62210866
98MP0002082_postnatal_lethality0.62210866
99MP0003632_abnormal_nervous_system0.61215862
100MP0008995_early_reproductive_senescence0.60470343

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.83700965
2Febrile seizures (HP:0002373)4.53667427
3Focal seizures (HP:0007359)4.39788741
4Atonic seizures (HP:0010819)4.32498009
5Hyperventilation (HP:0002883)3.97653954
6Limb dystonia (HP:0002451)3.96372809
7Polyphagia (HP:0002591)3.64262419
8Epileptic encephalopathy (HP:0200134)3.56030704
9Dialeptic seizures (HP:0011146)3.43230885
10Broad-based gait (HP:0002136)3.38148077
11Abnormality of the labia minora (HP:0012880)3.35774333
12Chronic hepatic failure (HP:0100626)3.35573913
13Pendular nystagmus (HP:0012043)3.32882817
14Hemiparesis (HP:0001269)3.21617672
15Myokymia (HP:0002411)3.15590832
16True hermaphroditism (HP:0010459)3.14842539
17Abnormality of midbrain morphology (HP:0002418)3.08939991
18Molar tooth sign on MRI (HP:0002419)3.08939991
19Drooling (HP:0002307)3.08746971
20Pancreatic fibrosis (HP:0100732)3.04225490
21Absence seizures (HP:0002121)3.02661323
22Progressive cerebellar ataxia (HP:0002073)3.01910139
23Pancreatic cysts (HP:0001737)3.01320775
24Gait imbalance (HP:0002141)3.00055985
25Failure to thrive in infancy (HP:0001531)2.86261744
26Generalized tonic-clonic seizures (HP:0002069)2.84051600
27Excessive salivation (HP:0003781)2.82433919
28Medial flaring of the eyebrow (HP:0010747)2.77881518
29Nephronophthisis (HP:0000090)2.76404182
30Esotropia (HP:0000565)2.72375678
31Lissencephaly (HP:0001339)2.64058630
32Retinal dysplasia (HP:0007973)2.60536984
33Congenital primary aphakia (HP:0007707)2.52155540
34Type II lissencephaly (HP:0007260)2.49885603
353-Methylglutaconic aciduria (HP:0003535)2.49739743
36Epileptiform EEG discharges (HP:0011182)2.49478733
37Nephrogenic diabetes insipidus (HP:0009806)2.46127642
38EEG with generalized epileptiform discharges (HP:0011198)2.45671103
39Agitation (HP:0000713)2.43441215
40Hypsarrhythmia (HP:0002521)2.41016043
41Pachygyria (HP:0001302)2.40562239
42Inability to walk (HP:0002540)2.30050128
43Hypothermia (HP:0002045)2.29145993
44Genital tract atresia (HP:0001827)2.28770523
45Vaginal atresia (HP:0000148)2.26172157
46Protruding tongue (HP:0010808)2.23677078
47Degeneration of the lateral corticospinal tracts (HP:0002314)2.23231784
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23231784
49Abnormality of the corticospinal tract (HP:0002492)2.22708264
50Hypoplasia of the brainstem (HP:0002365)2.21709877
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.21709877
52Abnormality of the renal medulla (HP:0100957)2.20341349
53Spastic tetraplegia (HP:0002510)2.19637507
54Status epilepticus (HP:0002133)2.18686822
55Cystic liver disease (HP:0006706)2.16711590
56Renal cortical cysts (HP:0000803)2.13439070
57Abnormal eating behavior (HP:0100738)2.08027070
58Abnormality of the renal cortex (HP:0011035)2.06586237
59Specific learning disability (HP:0001328)2.05782918
60Tubulointerstitial nephritis (HP:0001970)2.03613192
61Morphological abnormality of the pyramidal tract (HP:0002062)2.01384717
62Absent speech (HP:0001344)2.00659989
63Abnormal respiratory motile cilium morphology (HP:0005938)1.98317031
64Abnormal respiratory epithelium morphology (HP:0012253)1.98317031
65Abolished electroretinogram (ERG) (HP:0000550)1.98152875
66Large for gestational age (HP:0001520)1.97642356
67Cortical dysplasia (HP:0002539)1.95680752
68Bony spicule pigmentary retinopathy (HP:0007737)1.95203217
69Abnormal hair whorl (HP:0010721)1.94709898
70Hypomagnesemia (HP:0002917)1.92837988
71Anencephaly (HP:0002323)1.92707328
72Abnormal ciliary motility (HP:0012262)1.92559428
73Hepatoblastoma (HP:0002884)1.91493615
74Poor coordination (HP:0002370)1.90315420
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.89938280
76Muscular hypotonia of the trunk (HP:0008936)1.89401263
77Poor suck (HP:0002033)1.86686473
78Generalized myoclonic seizures (HP:0002123)1.86338508
79Ulnar claw (HP:0001178)1.85068900
80Growth hormone deficiency (HP:0000824)1.85023225
81Narrow forehead (HP:0000341)1.84148668
82Gaze-evoked nystagmus (HP:0000640)1.84003543
83Labial hypoplasia (HP:0000066)1.83222227
84Tubulointerstitial abnormality (HP:0001969)1.82544302
85Hypoalbuminemia (HP:0003073)1.82353874
86Abnormal albumin level (HP:0012116)1.82353874
87Hip dysplasia (HP:0001385)1.81269746
88Genetic anticipation (HP:0003743)1.81141445
89Sclerocornea (HP:0000647)1.79932285
90Oligomenorrhea (HP:0000876)1.79433249
91Urinary urgency (HP:0000012)1.76460277
92Buphthalmos (HP:0000557)1.74918823
93Concave nail (HP:0001598)1.73546774
94Optic nerve hypoplasia (HP:0000609)1.72290162
95Oligodactyly (hands) (HP:0001180)1.72042010
96Urinary bladder sphincter dysfunction (HP:0002839)1.70434849
97Postaxial foot polydactyly (HP:0001830)1.69419700
98Poor eye contact (HP:0000817)1.69255247
99Decreased muscle mass (HP:0003199)1.69037172
100Congenital stationary night blindness (HP:0007642)1.67603539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.62573218
2CASK4.06734639
3MAP3K43.08287176
4MAP2K72.53566800
5NTRK32.50848629
6MAPK132.49522472
7TNIK2.48094978
8PINK12.36338861
9PNCK2.31578568
10WNK32.25169104
11FRK2.12098374
12PAK32.00584871
13EPHA41.99074917
14MAP4K21.91806074
15MAP3K121.91782441
16SIK21.89593117
17DYRK21.82680011
18NTRK21.81178878
19UHMK11.71731179
20MAP2K41.64818774
21EPHA31.58208518
22BCR1.56147553
23BMPR1B1.42464751
24CAMKK21.42326700
25MINK11.41674644
26PRKCG1.39414268
27CSNK1G21.27126352
28MAPK151.24770126
29CCNB11.21034557
30PHKG11.14520073
31PHKG21.14520073
32MAP3K91.14048878
33KSR11.12912364
34CSNK1G31.07091241
35INSRR1.05878586
36CSNK1G11.03746403
37ADRBK21.02231921
38GRK10.97747283
39WNK40.97134518
40PRKCE0.96091976
41TRIM280.95431584
42TYRO30.95137595
43STK390.90026220
44CDK50.85993093
45CAMK2A0.84019503
46OXSR10.82869029
47SIK30.81991740
48CSNK1A1L0.77944329
49DYRK1A0.73538069
50DAPK20.72072517
51SGK20.71165788
52ERBB30.70067311
53SGK4940.68534816
54SGK2230.68534816
55CAMK2B0.68393394
56PLK20.66074231
57PRKCZ0.65954518
58EIF2AK30.63414201
59NUAK10.59459453
60PIK3CA0.59379333
61ACVR1B0.59210331
62CAMK1G0.59179254
63RAF10.58556204
64PKN10.58135363
65CAMK40.57562845
66STK160.56886582
67DYRK30.56032796
68CAMKK10.55639959
69PAK60.55353400
70NLK0.55351243
71AKT30.55054410
72SGK10.54994079
73RET0.54559407
74PRKG10.50532164
75CSNK1A10.49003108
76FGFR20.48997392
77MAP3K60.48703661
78PRKACA0.48693538
79CAMK10.46501152
80MKNK20.45972220
81STK380.43654158
82PRKACB0.43149900
83DMPK0.42419030
84STK38L0.41571881
85PLK40.41028346
86MAP3K50.40198129
87CDK30.39922652
88CSNK1E0.38625969
89MAP3K110.38037468
90MAPK40.37937083
91TSSK60.37606816
92PRKCQ0.36235100
93PRKAA10.35883468
94MARK20.35617611
95MAP3K20.35436172
96ADRBK10.34571240
97MAPKAPK50.34307320
98EPHB20.34145921
99CSNK1D0.33916021
100PRKCB0.31307988

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.85125989
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.71265040
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56458653
4GABAergic synapse_Homo sapiens_hsa047272.50815169
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.46189957
6Glutamatergic synapse_Homo sapiens_hsa047242.33127319
7Cocaine addiction_Homo sapiens_hsa050302.30081672
8Morphine addiction_Homo sapiens_hsa050322.19599557
9Amphetamine addiction_Homo sapiens_hsa050312.15995200
10Dopaminergic synapse_Homo sapiens_hsa047282.13260725
11Circadian entrainment_Homo sapiens_hsa047132.11710090
12Taste transduction_Homo sapiens_hsa047422.08044090
13Phototransduction_Homo sapiens_hsa047441.98155428
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94780685
15Synaptic vesicle cycle_Homo sapiens_hsa047211.91668685
16Insulin secretion_Homo sapiens_hsa049111.82940274
17Butanoate metabolism_Homo sapiens_hsa006501.80921215
18Cardiac muscle contraction_Homo sapiens_hsa042601.75799777
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67780293
20Linoleic acid metabolism_Homo sapiens_hsa005911.65172257
21Serotonergic synapse_Homo sapiens_hsa047261.64184263
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61322254
23Oxidative phosphorylation_Homo sapiens_hsa001901.58943887
24Protein export_Homo sapiens_hsa030601.58929574
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51713834
26Cholinergic synapse_Homo sapiens_hsa047251.50237224
27Selenocompound metabolism_Homo sapiens_hsa004501.48774477
28Parkinsons disease_Homo sapiens_hsa050121.47840360
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46279880
30Ether lipid metabolism_Homo sapiens_hsa005651.39880661
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39158718
32Axon guidance_Homo sapiens_hsa043601.33212111
33Long-term depression_Homo sapiens_hsa047301.33165259
34Type II diabetes mellitus_Homo sapiens_hsa049301.31677429
35Olfactory transduction_Homo sapiens_hsa047401.29108209
36Gap junction_Homo sapiens_hsa045401.19089137
37Collecting duct acid secretion_Homo sapiens_hsa049661.06361927
38Dorso-ventral axis formation_Homo sapiens_hsa043201.03449183
39Salivary secretion_Homo sapiens_hsa049700.98955974
40Alzheimers disease_Homo sapiens_hsa050100.98912926
41Huntingtons disease_Homo sapiens_hsa050160.98597695
42cAMP signaling pathway_Homo sapiens_hsa040240.97901148
43Steroid biosynthesis_Homo sapiens_hsa001000.97834757
44Long-term potentiation_Homo sapiens_hsa047200.95314081
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93390080
46Calcium signaling pathway_Homo sapiens_hsa040200.93362439
47Oxytocin signaling pathway_Homo sapiens_hsa049210.91690823
48Regulation of autophagy_Homo sapiens_hsa041400.91565647
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91019707
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79938728
51Nitrogen metabolism_Homo sapiens_hsa009100.79855564
52Circadian rhythm_Homo sapiens_hsa047100.78103115
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77447680
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77276386
55Gastric acid secretion_Homo sapiens_hsa049710.76096994
56Ovarian steroidogenesis_Homo sapiens_hsa049130.75836872
57Basal transcription factors_Homo sapiens_hsa030220.71287328
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69514626
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.68658199
60Renin secretion_Homo sapiens_hsa049240.68266929
61Fatty acid biosynthesis_Homo sapiens_hsa000610.65641788
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65216768
63Alcoholism_Homo sapiens_hsa050340.64774224
64Fat digestion and absorption_Homo sapiens_hsa049750.64694849
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63878540
66ABC transporters_Homo sapiens_hsa020100.62821498
67Estrogen signaling pathway_Homo sapiens_hsa049150.55322334
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53783702
69Pancreatic secretion_Homo sapiens_hsa049720.51071399
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49977664
71Ras signaling pathway_Homo sapiens_hsa040140.49480032
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49231952
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48147367
74Tryptophan metabolism_Homo sapiens_hsa003800.47990644
75Histidine metabolism_Homo sapiens_hsa003400.46812526
76MAPK signaling pathway_Homo sapiens_hsa040100.46630767
77GnRH signaling pathway_Homo sapiens_hsa049120.46441538
78Hedgehog signaling pathway_Homo sapiens_hsa043400.45592033
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.44909564
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41657102
81Melanogenesis_Homo sapiens_hsa049160.41571830
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39335938
83ErbB signaling pathway_Homo sapiens_hsa040120.36010403
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35676272
85Dilated cardiomyopathy_Homo sapiens_hsa054140.35197116
86Retinol metabolism_Homo sapiens_hsa008300.35117219
87Oocyte meiosis_Homo sapiens_hsa041140.34696315
88Bile secretion_Homo sapiens_hsa049760.34203403
89Prolactin signaling pathway_Homo sapiens_hsa049170.33260842
90Basal cell carcinoma_Homo sapiens_hsa052170.32846297
91Hippo signaling pathway_Homo sapiens_hsa043900.32577215
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29163805
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29075705
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28316397
95Phenylalanine metabolism_Homo sapiens_hsa003600.27749481
96Sulfur metabolism_Homo sapiens_hsa009200.26916921
97Tight junction_Homo sapiens_hsa045300.24540918
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23953154
99Peroxisome_Homo sapiens_hsa041460.23612844
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.23272298

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