ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.41743828
2	nucleobase catabolic process (GO:0046113)	3.66150954
3	paraxial mesoderm development (GO:0048339)	3.43996873
4	protein retention in ER lumen (GO:0006621)	2.93665398
5	cell migration in hindbrain (GO:0021535)	2.93510837
6	postsynaptic membrane organization (GO:0001941)	2.92748569
7	neuron recognition (GO:0008038)	2.72839604
8	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.68025503
9	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.63608633
10	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.63473959
11	axonal fasciculation (GO:0007413)	2.63391509
12	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.60851593
13	axon extension (GO:0048675)	2.59654932
14	synaptic vesicle maturation (GO:0016188)	2.58994054
15	presynaptic membrane assembly (GO:0097105)	2.51800973
16	glutamate secretion (GO:0014047)	2.50222229
17	layer formation in cerebral cortex (GO:0021819)	2.48089527
18	substrate-independent telencephalic tangential migration (GO:0021826)	2.46827389
19	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.46827389
20	L-serine metabolic process (GO:0006563)	2.43238560
21	establishment of mitochondrion localization (GO:0051654)	2.41832222
22	vocalization behavior (GO:0071625)	2.39699375
23	cerebral cortex radially oriented cell migration (GO:0021799)	2.37625731
24	neuron cell-cell adhesion (GO:0007158)	2.33790986
25	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.33130410
26	axon extension involved in axon guidance (GO:0048846)	2.33130410
27	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.31623359
28	ganglion development (GO:0061548)	2.29338142
29	presynaptic membrane organization (GO:0097090)	2.29257332
30	neuron projection extension (GO:1990138)	2.26231901
31	cellular protein complex localization (GO:0034629)	2.25938352
32	histone arginine methylation (GO:0034969)	2.24829267
33	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.24239630
34	COPI coating of Golgi vesicle (GO:0048205)	2.22714927
35	Golgi transport vesicle coating (GO:0048200)	2.22714927
36	cholesterol biosynthetic process (GO:0006695)	2.19377575
37	synaptic vesicle exocytosis (GO:0016079)	2.17436573
38	regulation of synaptic vesicle exocytosis (GO:2000300)	2.14918222
39	protein localization to synapse (GO:0035418)	2.14736433
40	positive regulation of synapse assembly (GO:0051965)	2.10751807
41	gamma-aminobutyric acid transport (GO:0015812)	2.10500459
42	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.10285737
43	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.07185745
44	protein complex localization (GO:0031503)	2.04501886
45	sterol biosynthetic process (GO:0016126)	2.03804683
46	vitamin transmembrane transport (GO:0035461)	2.02281406
47	peptidyl-arginine omega-N-methylation (GO:0035247)	2.00728849
48	protein neddylation (GO:0045116)	2.00388808
49	ventricular cardiac muscle cell development (GO:0055015)	2.00279755
50	hippocampus development (GO:0021766)	1.98479196
51	behavioral response to nicotine (GO:0035095)	1.97863465
52	notochord development (GO:0030903)	1.97733960
53	hippo signaling (GO:0035329)	1.97272841
54	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	1.97178237
55	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	1.96083792
56	planar cell polarity pathway involved in neural tube closure (GO:0090179)	1.95414116
57	ephrin receptor signaling pathway (GO:0048013)	1.94237617
58	regulation of synaptic vesicle transport (GO:1902803)	1.93300279
59	cell communication by electrical coupling (GO:0010644)	1.93070171
60	neuronal ion channel clustering (GO:0045161)	1.91885859
61	spinal cord development (GO:0021510)	1.91047172
62	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	1.90467924
63	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	1.90183759
64	negative chemotaxis (GO:0050919)	1.89362154
65	synaptic vesicle endocytosis (GO:0048488)	1.89247759
66	dendritic spine organization (GO:0097061)	1.88969092
67	establishment of monopolar cell polarity (GO:0061162)	1.88372711
68	establishment or maintenance of monopolar cell polarity (GO:0061339)	1.88372711
69	negative regulation of microtubule polymerization (GO:0031115)	1.88271514
70	neurotransmitter-gated ion channel clustering (GO:0072578)	1.88000723
71	sequestering of actin monomers (GO:0042989)	1.87060335
72	apical protein localization (GO:0045176)	1.86591620
73	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	1.86518130
74	negative regulation of chondrocyte differentiation (GO:0032331)	1.85752114
75	synapse assembly (GO:0007416)	1.85388061
76	limb bud formation (GO:0060174)	1.84888788
77	cerebral cortex cell migration (GO:0021795)	1.84749104
78	dendrite morphogenesis (GO:0048813)	1.84687567
79	positive regulation of mitochondrial fission (GO:0090141)	1.84226614
80	negative regulation of synaptic transmission, GABAergic (GO:0032229)	1.83850220
81	negative regulation of catenin import into nucleus (GO:0035414)	1.83553331
82	neurotransmitter secretion (GO:0007269)	1.83473483
83	establishment or maintenance of apical/basal cell polarity (GO:0035088)	1.83373323
84	establishment or maintenance of bipolar cell polarity (GO:0061245)	1.83373323
85	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	1.83341103
86	peptidyl-cysteine modification (GO:0018198)	1.82900813
87	regulation of synapse assembly (GO:0051963)	1.82020873
88	nonmotile primary cilium assembly (GO:0035058)	1.81740917
89	regulation of retinoic acid receptor signaling pathway (GO:0048385)	1.81069829
90	L-serine transport (GO:0015825)	1.80621922
91	developmental cell growth (GO:0048588)	1.80018706
92	asymmetric protein localization (GO:0008105)	1.79914365
93	neuronal action potential propagation (GO:0019227)	1.79439131
94	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	1.77579283
95	convergent extension (GO:0060026)	1.77172307
96	protein insertion into membrane (GO:0051205)	1.76800326
97	olfactory bulb development (GO:0021772)	1.76178140
98	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	1.75637135
99	cell communication involved in cardiac conduction (GO:0086065)	1.75302479
100	sodium ion export (GO:0071436)	1.74457005

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.62737171
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.00335956
3	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.35396226
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.31350068
5	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.19645457
6	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	2.06195440
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.90077980
8	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.82883777
9	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.74281296
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.72362398
11	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.64294289
12	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.64163205
13	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.64163205
14	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.61155316
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57373861
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.52909569
17	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.52906878
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.49904930
19	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.46308186
20	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.46236893
21	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.46186089
22	AR_21909140_ChIP-Seq_LNCAP_Human	1.45763982
23	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.40393398
24	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.38323101
25	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.36301494
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.35287906
27	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.34270910
28	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.31481209
29	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.29908582
30	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.28384554
31	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.25417495
32	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.23478907
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.22921091
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22547965
35	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22546850
36	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.22348352
37	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.20947800
38	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.18913772
39	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.18473516
40	CLOCK_20551151_ChIP-Seq_293T_Human	1.18321441
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16679615
42	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.16412733
43	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12637245
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.12558681
45	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12386351
46	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.12080644
47	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11306747
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10920817
49	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.10404443
50	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.10019494
51	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.08537713
52	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.07980909
53	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.07413550
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06998026
55	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.06357808
56	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.05523954
57	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.05036754
58	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.04668324
59	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.04483816
60	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04099672
61	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.04064409
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02459065
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.01778116
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.01295683
65	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.00758999
66	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.98739031
67	GBX2_23144817_ChIP-Seq_PC3_Human	0.98375095
68	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.98021734
69	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.97264730
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.96479570
71	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.96401174
72	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.95316730
73	EOMES_21245162_ChIP-Seq_HESCs_Human	0.95305975
74	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.94531385
75	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.93639366
76	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92355484
77	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.91387181
78	ZNF263_19887448_ChIP-Seq_K562_Human	0.90336538
79	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.87741509
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.87688787
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87586285
82	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.87273886
83	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.86987582
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86209615
85	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.85480107
86	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.85353210
87	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.85311235
88	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.84373155
89	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.84333256
90	SOX9_26525672_Chip-Seq_HEART_Mouse	0.83534352
91	TTF2_22483619_ChIP-Seq_HELA_Human	0.83469328
92	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.81439738
93	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.81427762
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.81254171
95	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.80136197
96	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.79918980
97	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.79226299
98	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.77834860
99	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	0.77683767
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.77665327

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	2.37479143
2	MP0004859_abnormal_synaptic_plasticity	2.23268460
3	MP0001529_abnormal_vocalization	2.21448511
4	MP0004270_analgesia	2.05922073
5	MP0010030_abnormal_orbit_morphology	2.05058100
6	MP0002653_abnormal_ependyma_morphology	2.03873213
7	MP0005394_taste/olfaction_phenotype	1.94783136
8	MP0005499_abnormal_olfactory_system	1.94783136
9	MP0002102_abnormal_ear_morphology	1.91710720
10	MP0000778_abnormal_nervous_system	1.90666530
11	MP0004272_abnormal_basement_membrane	1.81197624
12	MP0003880_abnormal_central_pattern	1.80407956
13	MP0005623_abnormal_meninges_morphology	1.80242737
14	MP0003123_paternal_imprinting	1.79358995
15	MP0008789_abnormal_olfactory_epithelium	1.77284302
16	MP0001984_abnormal_olfaction	1.65034328
17	MP0009780_abnormal_chondrocyte_physiolo	1.62295360
18	MP0000537_abnormal_urethra_morphology	1.56094861
19	MP0001299_abnormal_eye_distance/	1.51933001
20	MP0003385_abnormal_body_wall	1.47387409
21	MP0000049_abnormal_middle_ear	1.45440109
22	MP0002822_catalepsy	1.44717877
23	MP0000534_abnormal_ureter_morphology	1.42436752
24	MP0003942_abnormal_urinary_system	1.42303790
25	MP0003941_abnormal_skin_development	1.41463302
26	MP0006292_abnormal_olfactory_placode	1.41335085
27	MP0005257_abnormal_intraocular_pressure	1.39822802
28	MP0002233_abnormal_nose_morphology	1.39443550
29	MP0000566_synostosis	1.35781805
30	MP0003755_abnormal_palate_morphology	1.34544937
31	MP0002697_abnormal_eye_size	1.30592481
32	MP0003937_abnormal_limbs/digits/tail_de	1.28755978
33	MP0001293_anophthalmia	1.28602635
34	MP0003635_abnormal_synaptic_transmissio	1.28456302
35	MP0005409_darkened_coat_color	1.26155800
36	MP0003136_yellow_coat_color	1.24832283
37	MP0009053_abnormal_anal_canal	1.19945348
38	MP0003119_abnormal_digestive_system	1.18441618
39	MP0003861_abnormal_nervous_system	1.18345717
40	MP0006276_abnormal_autonomic_nervous	1.17105019
41	MP0002234_abnormal_pharynx_morphology	1.16105518
42	MP0002063_abnormal_learning/memory/cond	1.15451033
43	MP0005423_abnormal_somatic_nervous	1.13768744
44	MP0005187_abnormal_penis_morphology	1.12590979
45	MP0003121_genomic_imprinting	1.12279349
46	MP0000955_abnormal_spinal_cord	1.12124494
47	MP0003890_abnormal_embryonic-extraembry	1.11790025
48	MP0002938_white_spotting	1.10959854
49	MP0002734_abnormal_mechanical_nocicepti	1.09785413
50	MP0004811_abnormal_neuron_physiology	1.08887376
51	MP0001286_abnormal_eye_development	1.05925621
52	MP0001188_hyperpigmentation	1.03980218
53	MP0000579_abnormal_nail_morphology	1.02503781
54	MP0002184_abnormal_innervation	1.01460023
55	MP0005248_abnormal_Harderian_gland	1.00242201
56	MP0003315_abnormal_perineum_morphology	0.99861105
57	MP0000762_abnormal_tongue_morphology	0.99651896
58	MP0003705_abnormal_hypodermis_morpholog	0.98970732
59	MP0003329_amyloid_beta_deposits	0.96441655
60	MP0000751_myopathy	0.95717927
61	MP0002152_abnormal_brain_morphology	0.95246629
62	MP0002557_abnormal_social/conspecific_i	0.94668975
63	MP0002572_abnormal_emotion/affect_behav	0.94598184
64	MP0003938_abnormal_ear_development	0.94157434
65	MP0003935_abnormal_craniofacial_develop	0.93419002
66	MP0002882_abnormal_neuron_morphology	0.92360467
67	MP0003879_abnormal_hair_cell	0.92194724
68	MP0008932_abnormal_embryonic_tissue	0.90534274
69	MP0008438_abnormal_cutaneous_collagen	0.90479412
70	MP0002272_abnormal_nervous_system	0.90298056
71	MP0002249_abnormal_larynx_morphology	0.88128908
72	MP0002909_abnormal_adrenal_gland	0.87648380
73	MP0004133_heterotaxia	0.87329295
74	MP0004233_abnormal_muscle_weight	0.85774345
75	MP0002084_abnormal_developmental_patter	0.85679407
76	MP0002081_perinatal_lethality	0.85389769
77	MP0001346_abnormal_lacrimal_gland	0.84882895
78	MP0002064_seizures	0.84701148
79	MP0002092_abnormal_eye_morphology	0.83706505
80	MP0009745_abnormal_behavioral_response	0.83365281
81	MP0001502_abnormal_circadian_rhythm	0.81199941
82	MP0010368_abnormal_lymphatic_system	0.81066538
83	MP0009250_abnormal_appendicular_skeleto	0.80710772
84	MP0002752_abnormal_somatic_nervous	0.79215547
85	MP0002085_abnormal_embryonic_tissue	0.78860613
86	MP0002116_abnormal_craniofacial_bone	0.78802942
87	MP0009672_abnormal_birth_weight	0.77584283
88	MP0009384_cardiac_valve_regurgitation	0.77517612
89	MP0005197_abnormal_uvea_morphology	0.76203571
90	MP0002160_abnormal_reproductive_system	0.73999940
91	MP0000647_abnormal_sebaceous_gland	0.73638757
92	MP0001270_distended_abdomen	0.73118934
93	MP0001968_abnormal_touch/_nociception	0.71540866
94	MP0000026_abnormal_inner_ear	0.70848592
95	MP0005386_behavior/neurological_phenoty	0.70801496
96	MP0004924_abnormal_behavior	0.70801496
97	MP0000462_abnormal_digestive_system	0.66739953
98	MP0001340_abnormal_eyelid_morphology	0.66525582
99	MP0005391_vision/eye_phenotype	0.65925326
100	MP0002066_abnormal_motor_capabilities/c	0.65722426

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cortical dysplasia (HP:0002539)	2.90961424
2	Abnormality of glycolysis (HP:0004366)	2.68002067
3	Hepatoblastoma (HP:0002884)	2.48563405
4	Myokymia (HP:0002411)	2.40039414
5	Increased serum pyruvate (HP:0003542)	2.36452567
6	Split foot (HP:0001839)	2.23215615
7	Drooling (HP:0002307)	2.04455940
8	Gait imbalance (HP:0002141)	2.03855864
9	Pheochromocytoma (HP:0002666)	2.00698161
10	Retinal dysplasia (HP:0007973)	1.99580443
11	Vaginal atresia (HP:0000148)	1.94954597
12	Anophthalmia (HP:0000528)	1.88568123
13	Limb dystonia (HP:0002451)	1.87262316
14	Nephrogenic diabetes insipidus (HP:0009806)	1.83596904
15	Adrenal hypoplasia (HP:0000835)	1.82022332
16	High anterior hairline (HP:0009890)	1.81912850
17	Congenital primary aphakia (HP:0007707)	1.81407920
18	Genital tract atresia (HP:0001827)	1.80359504
19	Premature rupture of membranes (HP:0001788)	1.77403114
20	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.75005089
21	Choanal stenosis (HP:0000452)	1.73712901
22	Shallow orbits (HP:0000586)	1.73567581
23	Lissencephaly (HP:0001339)	1.73166640
24	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.71375060
25	Hypoplasia of the brainstem (HP:0002365)	1.71375060
26	Neuroendocrine neoplasm (HP:0100634)	1.70473557
27	Hypoglycemic seizures (HP:0002173)	1.69928773
28	Excessive salivation (HP:0003781)	1.68531703
29	Delayed CNS myelination (HP:0002188)	1.67530183
30	Hand muscle atrophy (HP:0009130)	1.64689104
31	Occipital encephalocele (HP:0002085)	1.62916137
32	Spastic diplegia (HP:0001264)	1.62886946
33	Upper limb muscle weakness (HP:0003484)	1.62226300
34	Amblyopia (HP:0000646)	1.62002536
35	Polyphagia (HP:0002591)	1.59552122
36	Myelomeningocele (HP:0002475)	1.59389074
37	Spastic tetraplegia (HP:0002510)	1.59306894
38	Exercise-induced muscle cramps (HP:0003710)	1.57886120
39	Spinal rigidity (HP:0003306)	1.55594010
40	Protrusio acetabuli (HP:0003179)	1.55214287
41	Dental crowding (HP:0000678)	1.53862663
42	Hydroureter (HP:0000072)	1.53284561
43	Poor coordination (HP:0002370)	1.52538015
44	Renal hypoplasia (HP:0000089)	1.52372670
45	Focal motor seizures (HP:0011153)	1.51964346
46	Abnormality of dentin (HP:0010299)	1.51728334
47	Bifid tongue (HP:0010297)	1.50630949
48	Absent eyebrow (HP:0002223)	1.48572886
49	Neoplasm of the peripheral nervous system (HP:0100007)	1.47998307
50	Medial flaring of the eyebrow (HP:0010747)	1.45208664
51	Focal seizures (HP:0007359)	1.44478364
52	Coronal craniosynostosis (HP:0004440)	1.44440633
53	Renal dysplasia (HP:0000110)	1.42502010
54	Partial duplication of thumb phalanx (HP:0009944)	1.41735951
55	Abnormality of the labia minora (HP:0012880)	1.41659534
56	Mutism (HP:0002300)	1.39468539
57	Labial hypoplasia (HP:0000066)	1.39439145
58	Generalized hypotonia (HP:0001290)	1.39356675
59	Micropenis (HP:0000054)	1.39282689
60	Exotropia (HP:0000577)	1.38968251
61	Abnormality of the aortic arch (HP:0012303)	1.37781520
62	Hypercalciuria (HP:0002150)	1.37242393
63	Scrotal hypoplasia (HP:0000046)	1.36679389
64	Hypoventilation (HP:0002791)	1.36563610
65	Generalized tonic-clonic seizures (HP:0002069)	1.35977231
66	Hypoplastic female external genitalia (HP:0012815)	1.35896850
67	Specific learning disability (HP:0001328)	1.35621763
68	Poor suck (HP:0002033)	1.35611517
69	Hypoplastic pelvis (HP:0008839)	1.34075627
70	Morphological abnormality of the middle ear (HP:0008609)	1.33891093
71	Abnormality of the lower motor neuron (HP:0002366)	1.33874062
72	Abnormal lung lobation (HP:0002101)	1.33606146
73	Missing ribs (HP:0000921)	1.33508689
74	Urinary urgency (HP:0000012)	1.33427586
75	Sleep apnea (HP:0010535)	1.32322273
76	Diastasis recti (HP:0001540)	1.31898566
77	Abnormality of magnesium homeostasis (HP:0004921)	1.31087019
78	Cutaneous finger syndactyly (HP:0010554)	1.30587685
79	Distal upper limb amyotrophy (HP:0007149)	1.30506787
80	Upper limb amyotrophy (HP:0009129)	1.30506787
81	Septo-optic dysplasia (HP:0100842)	1.29360161
82	Stenosis of the external auditory canal (HP:0000402)	1.29224875
83	Bicornuate uterus (HP:0000813)	1.29080491
84	Absent eyelashes (HP:0000561)	1.28508885
85	Limb-girdle muscle weakness (HP:0003325)	1.27690818
86	Congenital malformation of the right heart (HP:0011723)	1.27419965
87	Double outlet right ventricle (HP:0001719)	1.27419965
88	Pterygium (HP:0001059)	1.27141720
89	Insidious onset (HP:0003587)	1.27133054
90	Termporal pattern (HP:0011008)	1.27133054
91	Pachygyria (HP:0001302)	1.26896679
92	Failure to thrive in infancy (HP:0001531)	1.26695649
93	Midline defect of the nose (HP:0004122)	1.26659638
94	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.25543812
95	Optic nerve hypoplasia (HP:0000609)	1.25217076
96	Torticollis (HP:0000473)	1.24855198
97	Rimmed vacuoles (HP:0003805)	1.23412782
98	Cutaneous syndactyly (HP:0012725)	1.22685981
99	Arnold-Chiari malformation (HP:0002308)	1.22614973
100	Meningocele (HP:0002435)	1.22421131

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.48235285
2	CASK	2.28511055
3	BCR	2.26011627
4	TRIM28	2.20920047
5	LATS2	2.12551868
6	MAP2K7	2.08228583
7	EPHA4	2.07700126
8	EPHB2	2.03259120
9	WNK3	1.91036551
10	NTRK1	1.87732024
11	MAP3K4	1.75589082
12	PRKD3	1.75478205
13	LIMK1	1.70140902
14	LATS1	1.67395716
15	SRPK1	1.62809649
16	TYRO3	1.57682660
17	DYRK2	1.56678707
18	CSNK1G3	1.55068789
19	MINK1	1.52150093
20	CSNK1A1L	1.50864663
21	EPHA2	1.41449623
22	PAK6	1.41388680
23	PDGFRA	1.34698846
24	CSNK1G2	1.30187489
25	NTRK3	1.28463311
26	STK38L	1.26054705
27	CSNK1G1	1.25476851
28	TESK1	1.22458969
29	STK16	1.21915943
30	NTRK2	1.20914640
31	PHKG2	1.15995887
32	PHKG1	1.15995887
33	MAP3K9	1.10729802
34	ARAF	1.10001554
35	BUB1	1.09829604
36	MET	1.08372832
37	ICK	1.07754596
38	PTK2	1.06226025
39	LMTK2	1.04868078
40	DYRK1B	1.01837235
41	PLK3	0.99192466
42	ERBB3	0.97568321
43	MYLK	0.93967314
44	CDK14	0.93430599
45	PLK2	0.91299810
46	PRKCG	0.89672904
47	CLK1	0.89049239
48	PINK1	0.88577791
49	UHMK1	0.87822395
50	NEK1	0.87346564
51	STK3	0.87189600
52	CDK18	0.86153503
53	ERBB4	0.84291087
54	PAK3	0.82352072
55	STK38	0.81351914
56	FGFR2	0.81129558
57	CDK15	0.80632881
58	VRK2	0.80061585
59	TNIK	0.79941676
60	BRSK1	0.79273747
61	WEE1	0.77904112
62	CDK11A	0.75763046
63	EIF2AK1	0.74606666
64	BCKDK	0.74594473
65	KSR1	0.74036480
66	SGK494	0.73699631
67	SGK223	0.73699631
68	TSSK6	0.72303832
69	CDK8	0.71673596
70	TTK	0.69925606
71	EIF2AK3	0.67868457
72	CDK5	0.67233105
73	DYRK3	0.65584770
74	MAPK13	0.63602767
75	RIPK1	0.62403237
76	WNK4	0.60167910
77	EEF2K	0.59324787
78	PAK4	0.56318518
79	BMPR1B	0.56268831
80	DMPK	0.53234922
81	ROCK2	0.52497084
82	PLK1	0.52298232
83	BRAF	0.52269294
84	PAK2	0.52160491
85	PNCK	0.51176751
86	DYRK1A	0.50594437
87	AKT2	0.48124113
88	CSNK1E	0.47472574
89	PBK	0.47405939
90	CAMK2B	0.46397322
91	ABL2	0.43782222
92	ILK	0.42939724
93	PRKCE	0.42052833
94	CSNK1A1	0.41942024
95	CAMK2A	0.41722727
96	PKN1	0.40120000
97	PKN2	0.39925947
98	MAP2K4	0.39805470
99	CHEK2	0.39513750
100	CAMK2G	0.39506527

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Steroid biosynthesis_Homo sapiens_hsa00100	2.24963269
2	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.96805939
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.79452243
4	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.61819429
5	Hippo signaling pathway_Homo sapiens_hsa04390	1.61015935
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.59602631
7	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.54326895
8	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.54136221
9	Sulfur relay system_Homo sapiens_hsa04122	1.49948830
10	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.49838699
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.49324828
12	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.48999850
13	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.48844166
14	Axon guidance_Homo sapiens_hsa04360	1.38285116
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.37558326
16	Nicotine addiction_Homo sapiens_hsa05033	1.36730660
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.31749038
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.31648161
19	Vibrio cholerae infection_Homo sapiens_hsa05110	1.31593355
20	Basal cell carcinoma_Homo sapiens_hsa05217	1.25673583
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24198583
22	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.21896617
23	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20705258
24	GABAergic synapse_Homo sapiens_hsa04727	1.18260128
25	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.13757475
26	Fatty acid elongation_Homo sapiens_hsa00062	1.10039193
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.07924108
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.06840913
29	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06281220
30	Tight junction_Homo sapiens_hsa04530	1.04586488
31	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.03565215
32	Adherens junction_Homo sapiens_hsa04520	1.03304878
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.02933305
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.01298944
35	Wnt signaling pathway_Homo sapiens_hsa04310	0.98209827
36	Cocaine addiction_Homo sapiens_hsa05030	0.95153438
37	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94573962
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93504605
39	Carbon metabolism_Homo sapiens_hsa01200	0.93093570
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91421369
41	Butanoate metabolism_Homo sapiens_hsa00650	0.91102830
42	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.89758126
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89614909
44	Gap junction_Homo sapiens_hsa04540	0.89172050
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89131367
46	Melanogenesis_Homo sapiens_hsa04916	0.88637796
47	ECM-receptor interaction_Homo sapiens_hsa04512	0.88157174
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.87332431
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.87281909
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.86041927
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.82824810
52	Folate biosynthesis_Homo sapiens_hsa00790	0.81897098
53	Circadian rhythm_Homo sapiens_hsa04710	0.77935148
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.76517645
55	Propanoate metabolism_Homo sapiens_hsa00640	0.76309068
56	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.73572987
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.73109001
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.72322999
59	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.71196690
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70571173
61	Amphetamine addiction_Homo sapiens_hsa05031	0.69969833
62	Basal transcription factors_Homo sapiens_hsa03022	0.68301419
63	Protein export_Homo sapiens_hsa03060	0.66951642
64	Insulin secretion_Homo sapiens_hsa04911	0.66240327
65	Circadian entrainment_Homo sapiens_hsa04713	0.65621936
66	Oocyte meiosis_Homo sapiens_hsa04114	0.64967297
67	Sulfur metabolism_Homo sapiens_hsa00920	0.63071694
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.62993094
69	Fatty acid degradation_Homo sapiens_hsa00071	0.62947261
70	AMPK signaling pathway_Homo sapiens_hsa04152	0.60382139
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58952789
72	Parkinsons disease_Homo sapiens_hsa05012	0.57536810
73	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.56270427
74	Morphine addiction_Homo sapiens_hsa05032	0.56235284
75	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56123698
76	Huntingtons disease_Homo sapiens_hsa05016	0.56116375
77	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.54542647
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54452256
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.53896963
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53062742
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.52532538
82	Bile secretion_Homo sapiens_hsa04976	0.52369111
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52354845
84	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50411213
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.49662353
86	Glucagon signaling pathway_Homo sapiens_hsa04922	0.49422451
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48898551
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48753330
89	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.47370237
90	Galactose metabolism_Homo sapiens_hsa00052	0.47297274
91	Serotonergic synapse_Homo sapiens_hsa04726	0.47119347
92	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.46919789
93	Long-term depression_Homo sapiens_hsa04730	0.46904362
94	Oxidative phosphorylation_Homo sapiens_hsa00190	0.45976830
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45774944
96	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45192218
97	RNA polymerase_Homo sapiens_hsa03020	0.45143889
98	Cholinergic synapse_Homo sapiens_hsa04725	0.43553242
99	Alzheimers disease_Homo sapiens_hsa05010	0.42932641
100	Metabolic pathways_Homo sapiens_hsa01100	0.42301736

KIAA1191

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »