ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.19622491
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.55960220
3	DNA deamination (GO:0045006)	4.17211765
4	indolalkylamine catabolic process (GO:0046218)	3.99580617
5	tryptophan catabolic process (GO:0006569)	3.99580617
6	indole-containing compound catabolic process (GO:0042436)	3.99580617
7	fucose catabolic process (GO:0019317)	3.97543045
8	L-fucose metabolic process (GO:0042354)	3.97543045
9	L-fucose catabolic process (GO:0042355)	3.97543045
10	cellular response to ATP (GO:0071318)	3.93095977
11	response to pheromone (GO:0019236)	3.82642433
12	sulfation (GO:0051923)	3.79967145
13	gamma-aminobutyric acid transport (GO:0015812)	3.75670721
14	indolalkylamine metabolic process (GO:0006586)	3.64284560
15	kynurenine metabolic process (GO:0070189)	3.63556056
16	tryptophan metabolic process (GO:0006568)	3.56296241
17	cornea development in camera-type eye (GO:0061303)	3.41743307
18	cell proliferation in forebrain (GO:0021846)	3.27434725
19	axoneme assembly (GO:0035082)	3.23129855
20	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11874670
21	preassembly of GPI anchor in ER membrane (GO:0016254)	3.11812722
22	piRNA metabolic process (GO:0034587)	3.11581712
23	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.09191533
24	kidney morphogenesis (GO:0060993)	3.07120300
25	platelet dense granule organization (GO:0060155)	3.05960028
26	protein polyglutamylation (GO:0018095)	3.05201032
27	protein complex biogenesis (GO:0070271)	3.05044273
28	regulation of action potential (GO:0098900)	2.98587845
29	indole-containing compound metabolic process (GO:0042430)	2.94923384
30	GPI anchor metabolic process (GO:0006505)	2.93320725
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.92017395
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.92017395
33	NADH dehydrogenase complex assembly (GO:0010257)	2.92017395
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.90563077
35	dopamine transport (GO:0015872)	2.90037474
36	somite development (GO:0061053)	2.89961254
37	negative regulation of telomere maintenance (GO:0032205)	2.88996823
38	reflex (GO:0060004)	2.88715278
39	detection of light stimulus involved in sensory perception (GO:0050962)	2.88624312
40	detection of light stimulus involved in visual perception (GO:0050908)	2.88624312
41	negative regulation of mast cell activation (GO:0033004)	2.86201321
42	behavioral response to ethanol (GO:0048149)	2.85936762
43	photoreceptor cell development (GO:0042461)	2.82640543
44	nonmotile primary cilium assembly (GO:0035058)	2.82638086
45	negative regulation of T cell differentiation in thymus (GO:0033085)	2.82091166
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.81655645
47	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.81323820
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.79835352
49	regulation of posttranscriptional gene silencing (GO:0060147)	2.79420580
50	regulation of gene silencing by miRNA (GO:0060964)	2.79420580
51	regulation of gene silencing by RNA (GO:0060966)	2.79420580
52	neuronal action potential (GO:0019228)	2.76425722
53	pyrimidine nucleobase catabolic process (GO:0006208)	2.70902695
54	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.70219964
55	protein-cofactor linkage (GO:0018065)	2.69030439
56	parturition (GO:0007567)	2.67939330
57	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.67135244
58	transmission of nerve impulse (GO:0019226)	2.65227806
59	regulation of glomerulus development (GO:0090192)	2.64859140
60	nephron tubule morphogenesis (GO:0072078)	2.64451077
61	nephron epithelium morphogenesis (GO:0072088)	2.64451077
62	protein localization to cilium (GO:0061512)	2.64064322
63	negative regulation of response to food (GO:0032096)	2.63947724
64	negative regulation of appetite (GO:0032099)	2.63947724
65	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.62187740
66	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.62187740
67	cellular biogenic amine catabolic process (GO:0042402)	2.62132920
68	amine catabolic process (GO:0009310)	2.62132920
69	epithelial cilium movement (GO:0003351)	2.60270858
70	positive regulation of fatty acid transport (GO:2000193)	2.60061531
71	serotonin metabolic process (GO:0042428)	2.59250491
72	male meiosis I (GO:0007141)	2.58422340
73	respiratory chain complex IV assembly (GO:0008535)	2.56597357
74	synaptic transmission, cholinergic (GO:0007271)	2.53868517
75	eye photoreceptor cell development (GO:0042462)	2.53737251
76	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.52298190
77	primary amino compound metabolic process (GO:1901160)	2.50713286
78	regulation of meiosis I (GO:0060631)	2.49796349
79	spinal cord motor neuron differentiation (GO:0021522)	2.48034003
80	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.46846081
81	cilium morphogenesis (GO:0060271)	2.46830495
82	embryonic epithelial tube formation (GO:0001838)	2.46006096
83	regulation of hippo signaling (GO:0035330)	2.44942457
84	negative regulation of systemic arterial blood pressure (GO:0003085)	2.44830211
85	positive regulation of action potential (GO:0045760)	2.43195689
86	mannosylation (GO:0097502)	2.43130155
87	regulation of neurotransmitter uptake (GO:0051580)	2.42811804
88	ubiquinone biosynthetic process (GO:0006744)	2.41877534
89	cAMP catabolic process (GO:0006198)	2.41830351
90	protein K6-linked ubiquitination (GO:0085020)	2.41131165
91	retinal cone cell development (GO:0046549)	2.40683232
92	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.40575681
93	presynaptic membrane assembly (GO:0097105)	2.38888992
94	regulation of mesoderm development (GO:2000380)	2.38852058
95	cytidine deamination (GO:0009972)	2.38487410
96	cytidine metabolic process (GO:0046087)	2.38487410
97	cytidine catabolic process (GO:0006216)	2.38487410
98	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.38448328
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.38448328
100	ubiquinone metabolic process (GO:0006743)	2.38425628

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60595504
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.47352340
3	VDR_22108803_ChIP-Seq_LS180_Human	3.16610420
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.14190060
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.79064678
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49193487
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46541497
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.43957375
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41027396
10	FUS_26573619_Chip-Seq_HEK293_Human	2.23455598
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08199330
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.03928689
13	EWS_26573619_Chip-Seq_HEK293_Human	2.01332564
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.00438211
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97213745
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.91784929
17	P300_19829295_ChIP-Seq_ESCs_Human	1.90963911
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90529540
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.87641045
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86623800
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75274128
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.68093353
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67378257
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66083957
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.61416786
26	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.60727373
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60463204
28	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58018532
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.57365902
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.56116279
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54749027
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51711255
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.51711255
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49138172
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.48585448
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.48445452
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47544366
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46831907
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.44696441
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42601447
41	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41510661
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40150000
43	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.40043176
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38629212
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.38355867
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37646455
47	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36609439
48	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.36059998
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35239597
50	AR_25329375_ChIP-Seq_VCAP_Human	1.34756857
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32757386
52	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.32631400
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32058348
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31804817
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31207644
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31207644
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29284499
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.29255406
59	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29040823
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28695805
61	STAT3_23295773_ChIP-Seq_U87_Human	1.27233379
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.27000181
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26993075
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26993075
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26818931
66	TCF4_23295773_ChIP-Seq_U87_Human	1.26326938
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26127931
68	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26127931
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25940703
70	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.24243118
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21562807
72	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.21186995
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19991875
74	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19790446
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.18274374
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16806277
77	NCOR_22424771_ChIP-Seq_293T_Human	1.16467425
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14620048
79	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14393527
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13926286
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11853094
82	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.11827102
83	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.11669932
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08273686
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06562547
86	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05526849
87	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05165820
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04441825
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04322570
90	AR_20517297_ChIP-Seq_VCAP_Human	1.04279974
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03986047
92	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.02425549
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02307031
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01971044
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.01255957
96	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00095878
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00060051
98	AR_21572438_ChIP-Seq_LNCaP_Human	1.00037120
99	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99286074
100	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.97970512

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.46555278
2	MP0008877_abnormal_DNA_methylation	2.65734703
3	MP0003195_calcinosis	2.46506445
4	MP0002102_abnormal_ear_morphology	2.28229170
5	MP0005646_abnormal_pituitary_gland	2.28172233
6	MP0002837_dystrophic_cardiac_calcinosis	2.23277238
7	MP0001968_abnormal_touch/_nociception	2.18922665
8	MP0005551_abnormal_eye_electrophysiolog	2.18840584
9	MP0006072_abnormal_retinal_apoptosis	2.18792502
10	MP0004145_abnormal_muscle_electrophysio	2.01915785
11	MP0000631_abnormal_neuroendocrine_gland	2.00626505
12	MP0003136_yellow_coat_color	1.94792673
13	MP0002876_abnormal_thyroid_physiology	1.93103724
14	MP0008872_abnormal_physiological_respon	1.91376105
15	MP0004885_abnormal_endolymph	1.88580351
16	MP0009745_abnormal_behavioral_response	1.87130892
17	MP0003011_delayed_dark_adaptation	1.85108214
18	MP0004142_abnormal_muscle_tone	1.84439284
19	MP0004133_heterotaxia	1.84194510
20	MP0003646_muscle_fatigue	1.82154594
21	MP0001986_abnormal_taste_sensitivity	1.80643535
22	MP0002638_abnormal_pupillary_reflex	1.80343691
23	MP0002160_abnormal_reproductive_system	1.79848691
24	MP0001485_abnormal_pinna_reflex	1.76453704
25	MP0002272_abnormal_nervous_system	1.75195335
26	MP0003787_abnormal_imprinting	1.72866015
27	MP0008995_early_reproductive_senescence	1.72706201
28	MP0009046_muscle_twitch	1.71177608
29	MP0002736_abnormal_nociception_after	1.70221749
30	MP0002138_abnormal_hepatobiliary_system	1.63563796
31	MP0002938_white_spotting	1.60190995
32	MP0000372_irregular_coat_pigmentation	1.60105720
33	MP0005389_reproductive_system_phenotype	1.58990714
34	MP0005253_abnormal_eye_physiology	1.56152316
35	MP0008789_abnormal_olfactory_epithelium	1.55959334
36	MP0005084_abnormal_gallbladder_morpholo	1.52800136
37	MP0002277_abnormal_respiratory_mucosa	1.50836689
38	MP0002735_abnormal_chemical_nociception	1.48480041
39	MP0002653_abnormal_ependyma_morphology	1.41196579
40	MP0006276_abnormal_autonomic_nervous	1.40088614
41	MP0003880_abnormal_central_pattern	1.36504833
42	MP0002064_seizures	1.31980571
43	MP0005645_abnormal_hypothalamus_physiol	1.31686998
44	MP0008875_abnormal_xenobiotic_pharmacok	1.31521174
45	MP0002734_abnormal_mechanical_nocicepti	1.30371935
46	MP0001501_abnormal_sleep_pattern	1.30253533
47	MP0002733_abnormal_thermal_nociception	1.29836452
48	MP0000049_abnormal_middle_ear	1.28130938
49	MP0010386_abnormal_urinary_bladder	1.28056571
50	MP0001970_abnormal_pain_threshold	1.24353698
51	MP0005410_abnormal_fertilization	1.23928278
52	MP0002572_abnormal_emotion/affect_behav	1.22971498
53	MP0002557_abnormal_social/conspecific_i	1.21575606
54	MP0001984_abnormal_olfaction	1.20407316
55	MP0001919_abnormal_reproductive_system	1.17825365
56	MP0001529_abnormal_vocalization	1.17012984
57	MP0003283_abnormal_digestive_organ	1.16875822
58	MP0002163_abnormal_gland_morphology	1.16662216
59	MP0002928_abnormal_bile_duct	1.14841093
60	MP0001486_abnormal_startle_reflex	1.11720406
61	MP0001905_abnormal_dopamine_level	1.10362418
62	MP0005394_taste/olfaction_phenotype	1.08099868
63	MP0005499_abnormal_olfactory_system	1.08099868
64	MP0002751_abnormal_autonomic_nervous	1.06227056
65	MP0004134_abnormal_chest_morphology	1.04697239
66	MP0003718_maternal_effect	1.04363924
67	MP0002909_abnormal_adrenal_gland	1.03649399
68	MP0000026_abnormal_inner_ear	1.03308197
69	MP0005195_abnormal_posterior_eye	1.01782425
70	MP0003121_genomic_imprinting	1.00653807
71	MP0004215_abnormal_myocardial_fiber	1.00638947
72	MP0003938_abnormal_ear_development	1.00336915
73	MP0003567_abnormal_fetal_cardiomyocyte	0.99575085
74	MP0005379_endocrine/exocrine_gland_phen	0.99343359
75	MP0002752_abnormal_somatic_nervous	0.97107129
76	MP0002063_abnormal_learning/memory/cond	0.97013865
77	MP0001293_anophthalmia	0.96188947
78	MP0003635_abnormal_synaptic_transmissio	0.95402135
79	MP0002184_abnormal_innervation	0.94566610
80	MP0005386_behavior/neurological_phenoty	0.91975709
81	MP0004924_abnormal_behavior	0.91975709
82	MP0000778_abnormal_nervous_system	0.91302526
83	MP0002067_abnormal_sensory_capabilities	0.91210969
84	MP0000427_abnormal_hair_cycle	0.90454382
85	MP0002234_abnormal_pharynx_morphology	0.90043821
86	MP0001963_abnormal_hearing_physiology	0.89164544
87	MP0003937_abnormal_limbs/digits/tail_de	0.88113198
88	MP0001440_abnormal_grooming_behavior	0.88044022
89	MP0004043_abnormal_pH_regulation	0.86763876
90	MP0000230_abnormal_systemic_arterial	0.85530741
91	MP0005174_abnormal_tail_pigmentation	0.84508175
92	MP0004742_abnormal_vestibular_system	0.82997913
93	MP0009250_abnormal_appendicular_skeleto	0.81433593
94	MP0003119_abnormal_digestive_system	0.79526000
95	MP0001324_abnormal_eye_pigmentation	0.78360361
96	MP0003698_abnormal_male_reproductive	0.77707076
97	MP0002210_abnormal_sex_determination	0.77334618
98	MP0000653_abnormal_sex_gland	0.77177588
99	MP0005075_abnormal_melanosome_morpholog	0.76754196
100	MP0001502_abnormal_circadian_rhythm	0.75432507

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.65170077
2	Pancreatic fibrosis (HP:0100732)	4.25338255
3	True hermaphroditism (HP:0010459)	4.12320201
4	Abnormality of midbrain morphology (HP:0002418)	3.68908335
5	Molar tooth sign on MRI (HP:0002419)	3.68908335
6	Pendular nystagmus (HP:0012043)	3.62621364
7	Nephronophthisis (HP:0000090)	3.59699321
8	Congenital stationary night blindness (HP:0007642)	3.44126753
9	Abolished electroretinogram (ERG) (HP:0000550)	3.25609765
10	Cystic liver disease (HP:0006706)	3.06423122
11	Abnormality of the renal medulla (HP:0100957)	3.03053121
12	Type II lissencephaly (HP:0007260)	3.02796825
13	Progressive cerebellar ataxia (HP:0002073)	3.00258726
14	Congenital, generalized hypertrichosis (HP:0004540)	2.97175258
15	Abnormality of the renal cortex (HP:0011035)	2.95557614
16	Methylmalonic acidemia (HP:0002912)	2.77664603
17	Aplasia/hypoplasia of the uterus (HP:0008684)	2.76821454
18	3-Methylglutaconic aciduria (HP:0003535)	2.76130571
19	Genetic anticipation (HP:0003743)	2.74324534
20	Keratoconus (HP:0000563)	2.73894575
21	Increased corneal curvature (HP:0100692)	2.73894575
22	Sclerocornea (HP:0000647)	2.68908211
23	Male pseudohermaphroditism (HP:0000037)	2.65607365
24	Hypoplasia of the uterus (HP:0000013)	2.58026100
25	Agitation (HP:0000713)	2.55325543
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53293321
27	Medial flaring of the eyebrow (HP:0010747)	2.51482664
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.50882256
29	Tubular atrophy (HP:0000092)	2.49997000
30	Furrowed tongue (HP:0000221)	2.46538439
31	Optic nerve hypoplasia (HP:0000609)	2.46370553
32	Decreased central vision (HP:0007663)	2.41331805
33	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.37281704
34	Gaze-evoked nystagmus (HP:0000640)	2.37188093
35	Hypothermia (HP:0002045)	2.35229004
36	Methylmalonic aciduria (HP:0012120)	2.33427836
37	Septo-optic dysplasia (HP:0100842)	2.31205891
38	Attenuation of retinal blood vessels (HP:0007843)	2.29635803
39	Acute necrotizing encephalopathy (HP:0006965)	2.29213955
40	Chronic hepatic failure (HP:0100626)	2.25595258
41	Inability to walk (HP:0002540)	2.23230952
42	Renal cortical cysts (HP:0000803)	2.20510003
43	Anencephaly (HP:0002323)	2.20099531
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16020203
45	Abnormal drinking behavior (HP:0030082)	2.15841309
46	Polydipsia (HP:0001959)	2.15841309
47	Mitochondrial inheritance (HP:0001427)	2.15547810
48	Concave nail (HP:0001598)	2.14988108
49	Progressive macrocephaly (HP:0004481)	2.13438059
50	Hemiparesis (HP:0001269)	2.12828396
51	Abnormal respiratory epithelium morphology (HP:0012253)	2.10706592
52	Abnormal respiratory motile cilium morphology (HP:0005938)	2.10706592
53	Congenital sensorineural hearing impairment (HP:0008527)	2.09490863
54	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08500754
55	Acute encephalopathy (HP:0006846)	2.05831105
56	Hyperglycinemia (HP:0002154)	2.04617042
57	Broad-based gait (HP:0002136)	2.04582497
58	Increased CSF lactate (HP:0002490)	2.04562379
59	Congenital hepatic fibrosis (HP:0002612)	2.03953794
60	Hyperventilation (HP:0002883)	2.03566682
61	Lissencephaly (HP:0001339)	1.99810604
62	Asplenia (HP:0001746)	1.98315970
63	Decreased circulating renin level (HP:0003351)	1.95940574
64	Abnormality of the labia minora (HP:0012880)	1.95621078
65	Chorioretinal atrophy (HP:0000533)	1.94600974
66	Aplasia/Hypoplasia of the patella (HP:0006498)	1.93406809
67	Lipid accumulation in hepatocytes (HP:0006561)	1.92192538
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89349327
69	Progressive inability to walk (HP:0002505)	1.88729850
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.88671442
71	Absent/shortened dynein arms (HP:0200106)	1.88671442
72	Severe muscular hypotonia (HP:0006829)	1.87233941
73	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87146280
74	Increased hepatocellular lipid droplets (HP:0006565)	1.86864868
75	Abnormal ciliary motility (HP:0012262)	1.85935757
76	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.85606063
77	Hypoplasia of the fovea (HP:0007750)	1.85606063
78	Patellar aplasia (HP:0006443)	1.84899975
79	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.84383344
80	Bile duct proliferation (HP:0001408)	1.84081597
81	Abnormal biliary tract physiology (HP:0012439)	1.84081597
82	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.81689615
83	Gait imbalance (HP:0002141)	1.81508009
84	Short hallux (HP:0010109)	1.81468183
85	Cerebellar dysplasia (HP:0007033)	1.81325046
86	Pachygyria (HP:0001302)	1.80361799
87	Postaxial foot polydactyly (HP:0001830)	1.79587086
88	Large for gestational age (HP:0001520)	1.78517246
89	Abnormal number of erythroid precursors (HP:0012131)	1.78461923
90	Retinal dysplasia (HP:0007973)	1.76469360
91	Confusion (HP:0001289)	1.76228062
92	Abnormality of alanine metabolism (HP:0010916)	1.74755256
93	Hyperalaninemia (HP:0003348)	1.74755256
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74755256
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.74530959
96	Polyuria (HP:0000103)	1.74110311
97	Short tibia (HP:0005736)	1.71737849
98	Hepatocellular necrosis (HP:0001404)	1.71412629
99	Hypoplasia of the pons (HP:0012110)	1.71197053
100	Congenital primary aphakia (HP:0007707)	1.69615344

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.80604670
2	ADRBK2	3.35168010
3	BMPR1B	3.16608615
4	GRK1	3.01024921
5	PINK1	2.98690190
6	ZAK	2.68536002
7	WNK3	2.65463711
8	TAOK3	2.64495833
9	MAP4K2	2.57578092
10	NUAK1	2.20359927
11	TLK1	2.03192012
12	MAPK13	2.03019920
13	WNK4	2.02539918
14	TNIK	1.96440348
15	INSRR	1.75340201
16	DYRK2	1.67219189
17	CASK	1.66242992
18	MAP3K4	1.65358357
19	ACVR1B	1.48519965
20	MARK1	1.45440191
21	TXK	1.44848535
22	STK16	1.36480434
23	MKNK2	1.31834037
24	OXSR1	1.31625862
25	STK39	1.28766597
26	PAK3	1.27104615
27	PHKG2	1.26851169
28	PHKG1	1.26851169
29	DAPK2	1.23362818
30	VRK1	1.08557573
31	PNCK	1.06549397
32	PRKCG	1.04644978
33	VRK2	1.03874015
34	CSNK1G2	0.99988951
35	ADRBK1	0.98288371
36	CSNK1G1	0.97632376
37	PLK2	0.97334925
38	TGFBR1	0.97260931
39	FGFR2	0.93680713
40	PRKCE	0.93658586
41	TIE1	0.90797561
42	STK38L	0.90500107
43	CSNK1G3	0.89062597
44	MAP2K7	0.83982782
45	RPS6KA5	0.79441729
46	MST4	0.76474428
47	TAF1	0.75686221
48	MAPKAPK3	0.74936552
49	BCR	0.73606701
50	PLK3	0.72711808
51	BCKDK	0.72229846
52	PTK2B	0.72046727
53	FLT3	0.71903851
54	ERBB3	0.70707079
55	PIK3CA	0.69808302
56	NTRK2	0.69249878
57	TRIM28	0.68614302
58	MKNK1	0.67364768
59	PRKCQ	0.66380324
60	MAPKAPK5	0.64072004
61	PRKCI	0.63231641
62	MUSK	0.62767323
63	IKBKB	0.62367354
64	AKT3	0.61473117
65	CAMK2A	0.61100594
66	NME1	0.60007865
67	TEC	0.59389103
68	CSNK1A1	0.59218211
69	MAPK15	0.57843729
70	BRSK2	0.57779195
71	PRKACA	0.55407898
72	NTRK3	0.55157565
73	PKN1	0.52920903
74	CSNK1A1L	0.52580911
75	EIF2AK3	0.49650043
76	MAP2K6	0.48427062
77	TNK2	0.47389823
78	CAMKK2	0.45869026
79	KIT	0.45811381
80	MAP2K2	0.44762714
81	PRKD2	0.43921989
82	MARK3	0.43431331
83	NLK	0.43199446
84	PRKCZ	0.42359980
85	DYRK1A	0.42304426
86	CHUK	0.40646045
87	CAMK1	0.40398540
88	CDK8	0.39852375
89	PRKCA	0.39319502
90	OBSCN	0.38425614
91	ITK	0.36421917
92	PLK4	0.33490281
93	SGK223	0.31784624
94	SGK494	0.31784624
95	CSNK1D	0.31711023
96	SGK2	0.31649505
97	RPS6KA6	0.30600284
98	GRK7	0.29519434
99	ABL1	0.28729628
100	MAP2K1	0.28049046

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.81657982
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.62952542
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61728129
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.46525355
5	Protein export_Homo sapiens_hsa03060	2.37508658
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.27878501
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.26776199
8	Nicotine addiction_Homo sapiens_hsa05033	2.15413107
9	Parkinsons disease_Homo sapiens_hsa05012	2.15326716
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.14373704
11	Homologous recombination_Homo sapiens_hsa03440	1.97238032
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.96906074
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.96643864
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88065793
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87450244
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.84785777
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79373603
18	Butanoate metabolism_Homo sapiens_hsa00650	1.78252151
19	RNA polymerase_Homo sapiens_hsa03020	1.72204874
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.71868411
21	Basal transcription factors_Homo sapiens_hsa03022	1.57785055
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.57185092
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.56052375
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.53045097
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.49274604
26	Asthma_Homo sapiens_hsa05310	1.46823660
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38249649
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.37066524
29	Alzheimers disease_Homo sapiens_hsa05010	1.36941138
30	Huntingtons disease_Homo sapiens_hsa05016	1.33079297
31	Morphine addiction_Homo sapiens_hsa05032	1.31117707
32	Taste transduction_Homo sapiens_hsa04742	1.29509285
33	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23891718
34	Propanoate metabolism_Homo sapiens_hsa00640	1.22525692
35	RNA degradation_Homo sapiens_hsa03018	1.21961666
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.21431941
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20559223
38	Ribosome_Homo sapiens_hsa03010	1.15121316
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.14576269
40	Olfactory transduction_Homo sapiens_hsa04740	1.14154842
41	Caffeine metabolism_Homo sapiens_hsa00232	1.13029676
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10334360
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09235236
44	Sulfur metabolism_Homo sapiens_hsa00920	1.03484703
45	Type I diabetes mellitus_Homo sapiens_hsa04940	1.02833639
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01939817
47	Insulin secretion_Homo sapiens_hsa04911	1.00405589
48	Retinol metabolism_Homo sapiens_hsa00830	0.94458144
49	Peroxisome_Homo sapiens_hsa04146	0.92505637
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.92111602
51	GABAergic synapse_Homo sapiens_hsa04727	0.91995260
52	Serotonergic synapse_Homo sapiens_hsa04726	0.91692587
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.90799332
54	Circadian entrainment_Homo sapiens_hsa04713	0.90444818
55	Allograft rejection_Homo sapiens_hsa05330	0.90059819
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.89518124
57	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.89172735
58	One carbon pool by folate_Homo sapiens_hsa00670	0.88425632
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86087230
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.84472611
61	Graft-versus-host disease_Homo sapiens_hsa05332	0.83676732
62	Proteasome_Homo sapiens_hsa03050	0.82618365
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.81597168
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77713697
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77706684
66	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76390687
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76268176
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.74984758
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.74658258
70	Purine metabolism_Homo sapiens_hsa00230	0.69793546
71	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67811532
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67348063
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67129552
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65388409
75	Cocaine addiction_Homo sapiens_hsa05030	0.63939379
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.63697415
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62721633
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60121452
79	ABC transporters_Homo sapiens_hsa02010	0.58948048
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58817761
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57758619
82	Metabolic pathways_Homo sapiens_hsa01100	0.56387441
83	Regulation of autophagy_Homo sapiens_hsa04140	0.56017418
84	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54286019
85	Salivary secretion_Homo sapiens_hsa04970	0.53204106
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53084158
87	Histidine metabolism_Homo sapiens_hsa00340	0.50599072
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48798435
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47967187
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.46383886
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45418418
92	Amphetamine addiction_Homo sapiens_hsa05031	0.45222154
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.44151559
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.43639138
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39743422
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39370099
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39093776
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37590338
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.37431571
100	Basal cell carcinoma_Homo sapiens_hsa05217	0.36324788

KIAA1210

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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