ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.81020355
2	nucleobase catabolic process (GO:0046113)	4.89650512
3	presynaptic membrane assembly (GO:0097105)	4.65794512
4	postsynaptic membrane organization (GO:0001941)	4.35050030
5	presynaptic membrane organization (GO:0097090)	4.31661827
6	cell migration in hindbrain (GO:0021535)	4.19408113
7	axonal fasciculation (GO:0007413)	4.13632628
8	neuron cell-cell adhesion (GO:0007158)	4.08195371
9	neuron recognition (GO:0008038)	3.92997047
10	protein-DNA complex disassembly (GO:0032986)	3.86450185
11	nucleosome disassembly (GO:0006337)	3.86450185
12	layer formation in cerebral cortex (GO:0021819)	3.82137964
13	establishment of mitochondrion localization (GO:0051654)	3.65079480
14	central nervous system projection neuron axonogenesis (GO:0021952)	3.56506350
15	cranial nerve morphogenesis (GO:0021602)	3.41047130
16	vocalization behavior (GO:0071625)	3.40649057
17	neurotransmitter-gated ion channel clustering (GO:0072578)	3.33282469
18	protein localization to synapse (GO:0035418)	3.30588688
19	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.22476909
20	mitochondrion transport along microtubule (GO:0047497)	3.22476909
21	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.20371788
22	regulation of NFAT protein import into nucleus (GO:0051532)	3.19871728
23	establishment of nucleus localization (GO:0040023)	3.08522879
24	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.06434648
25	auditory behavior (GO:0031223)	3.04277546
26	microtubule severing (GO:0051013)	2.97768882
27	dendritic spine morphogenesis (GO:0060997)	2.92891721
28	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.92070753
29	cerebral cortex radially oriented cell migration (GO:0021799)	2.91837173
30	dendrite morphogenesis (GO:0048813)	2.90505130
31	acrosome reaction (GO:0007340)	2.90461477
32	microtubule depolymerization (GO:0007019)	2.87855030
33	central nervous system neuron axonogenesis (GO:0021955)	2.86017229
34	paraxial mesoderm development (GO:0048339)	2.84997419
35	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.81711298
36	mechanosensory behavior (GO:0007638)	2.77638865
37	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.74589123
38	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.74560354
39	regulation of synaptic vesicle exocytosis (GO:2000300)	2.72167342
40	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.68900269
41	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.67109926
42	dendritic spine organization (GO:0097061)	2.64810577
43	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.62864418
44	glutamate receptor signaling pathway (GO:0007215)	2.59470221
45	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.58739921
46	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.56837857
47	spinal cord development (GO:0021510)	2.55410411
48	axon extension (GO:0048675)	2.55001550
49	negative regulation of dendrite development (GO:2000171)	2.54833165
50	synapse assembly (GO:0007416)	2.54801356
51	chromosome condensation (GO:0030261)	2.53035195
52	apical protein localization (GO:0045176)	2.50905460
53	response to auditory stimulus (GO:0010996)	2.50576722
54	positive regulation of synapse maturation (GO:0090129)	2.48094190
55	positive regulation of synapse assembly (GO:0051965)	2.47227719
56	ephrin receptor signaling pathway (GO:0048013)	2.46994566
57	locomotory exploration behavior (GO:0035641)	2.46889785
58	exploration behavior (GO:0035640)	2.46803791
59	sperm motility (GO:0030317)	2.45824759
60	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.45605693
61	negative regulation of microtubule polymerization (GO:0031115)	2.44852807
62	neuron migration (GO:0001764)	2.44769374
63	convergent extension (GO:0060026)	2.44165146
64	dendrite development (GO:0016358)	2.43613626
65	neuronal ion channel clustering (GO:0045161)	2.43298313
66	synaptic transmission, glutamatergic (GO:0035249)	2.42129084
67	gastrulation with mouth forming second (GO:0001702)	2.40081634
68	regulation of glutamate receptor signaling pathway (GO:1900449)	2.39485627
69	neuronal stem cell maintenance (GO:0097150)	2.39034318
70	regulation of neuron migration (GO:2001222)	2.38820214
71	receptor recycling (GO:0001881)	2.38791140
72	enteric nervous system development (GO:0048484)	2.37540670
73	sympathetic nervous system development (GO:0048485)	2.36948908
74	negative regulation of dendrite morphogenesis (GO:0050774)	2.36228306
75	DNA packaging (GO:0006323)	2.35329701
76	positive regulation of dendrite morphogenesis (GO:0050775)	2.34879215
77	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.33898637
78	synaptic vesicle maturation (GO:0016188)	2.32287327
79	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.30599299
80	organelle transport along microtubule (GO:0072384)	2.29624970
81	dopamine receptor signaling pathway (GO:0007212)	2.29526636
82	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.29217352
83	hippocampus development (GO:0021766)	2.28951352
84	glomerulus development (GO:0032835)	2.28489743
85	suckling behavior (GO:0001967)	2.28420923
86	regulation of axon guidance (GO:1902667)	2.27893774
87	sexual reproduction (GO:0019953)	2.27759672
88	spermatid nucleus differentiation (GO:0007289)	2.27390417
89	epithelial cell differentiation involved in kidney development (GO:0035850)	2.26933103
90	establishment or maintenance of bipolar cell polarity (GO:0061245)	2.24248144
91	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.24248144
92	neuron projection extension (GO:1990138)	2.23867620
93	axon extension involved in axon guidance (GO:0048846)	2.23711420
94	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.23711420
95	axonogenesis (GO:0007409)	2.23625896
96	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.23468414
97	ganglion development (GO:0061548)	2.22376005
98	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.22323097
99	cerebral cortex neuron differentiation (GO:0021895)	2.22153947
100	histone H3-K9 demethylation (GO:0033169)	2.22006273

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.96003546
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.78646513
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.63007688
4	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.53703236
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.30962845
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.22920043
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.22481229
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.18707025
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.09114455
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.08320911
11	REST_21632747_ChIP-Seq_MESCs_Mouse	2.01390130
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.01381023
13	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.98819546
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.98819546
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.91570573
16	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.88126857
17	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.86720930
18	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.81941561
19	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.80664954
20	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.79442526
21	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.78790288
22	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.75315283
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.74665930
24	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.73340370
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.72570972
26	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.69453694
27	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.67243640
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.66605047
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64772294
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.64772294
31	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60344968
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.60068344
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.59782362
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59658838
35	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.58534884
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.52455807
37	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.51803445
38	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.51550828
39	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.50333542
40	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.49642645
41	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49042883
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.48252157
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48229659
44	FUS_26573619_Chip-Seq_HEK293_Human	1.48184413
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47579499
46	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.46548684
47	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.46131133
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.45154395
49	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.45154331
50	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.40858602
51	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40303394
52	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.38660386
53	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.38358987
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38059480
55	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.33936055
56	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.31947957
57	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.27640583
58	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.27211385
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26808917
60	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.24586414
61	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.23901740
62	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.22426916
63	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20542160
64	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.17438646
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16880115
66	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.15447153
67	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.15273039
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14913923
69	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.14499285
70	P300_19829295_ChIP-Seq_ESCs_Human	1.13549775
71	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.12388905
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11644114
73	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.11438216
74	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11083529
75	SOX9_26525672_Chip-Seq_HEART_Mouse	1.11065363
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10083521
77	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09501056
78	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.08636163
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.08371060
80	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07841987
81	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06955806
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06277135
83	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.05533274
84	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.05509455
85	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.05127913
86	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04665961
87	AR_19668381_ChIP-Seq_PC3_Human	1.03762352
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.03639386
89	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02977827
90	KDM2B_26808549_Chip-Seq_K562_Human	1.01140915
91	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00892023
92	* SMAD4_21741376_ChIP-Seq_HESCs_Human	0.99503789
93	CTCF_27219007_Chip-Seq_Bcells_Human	0.98827824
94	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.97053445
95	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.95787213
96	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.94869111
97	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94000827
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.91699322
99	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.90784374
100	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.90774752

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.93117427
2	MP0004859_abnormal_synaptic_plasticity	3.42498655
3	MP0000778_abnormal_nervous_system	3.07588645
4	MP0004270_analgesia	3.03969356
5	MP0005423_abnormal_somatic_nervous	2.29597404
6	MP0000537_abnormal_urethra_morphology	2.17618717
7	MP0003122_maternal_imprinting	2.14399564
8	MP0005409_darkened_coat_color	2.03848081
9	MP0001188_hyperpigmentation	1.99954439
10	MP0003635_abnormal_synaptic_transmissio	1.83778051
11	MP0000566_synostosis	1.82217597
12	MP0002734_abnormal_mechanical_nocicepti	1.81791337
13	MP0000955_abnormal_spinal_cord	1.81011361
14	MP0003119_abnormal_digestive_system	1.74224503
15	MP0002735_abnormal_chemical_nociception	1.72618142
16	MP0002184_abnormal_innervation	1.68820184
17	MP0003880_abnormal_central_pattern	1.67611512
18	MP0003861_abnormal_nervous_system	1.66689309
19	MP0001529_abnormal_vocalization	1.60980929
20	MP0006276_abnormal_autonomic_nervous	1.59162761
21	MP0002063_abnormal_learning/memory/cond	1.54490890
22	MP0002697_abnormal_eye_size	1.50625425
23	MP0001984_abnormal_olfaction	1.48369036
24	MP0005248_abnormal_Harderian_gland	1.48352264
25	MP0004811_abnormal_neuron_physiology	1.47530053
26	MP0003136_yellow_coat_color	1.44748060
27	MP0002751_abnormal_autonomic_nervous	1.43951460
28	MP0000534_abnormal_ureter_morphology	1.43236269
29	MP0002249_abnormal_larynx_morphology	1.42704283
30	MP0002557_abnormal_social/conspecific_i	1.42438920
31	MP0002152_abnormal_brain_morphology	1.41584046
32	MP0002882_abnormal_neuron_morphology	1.39858485
33	MP0001486_abnormal_startle_reflex	1.35621850
34	MP0002572_abnormal_emotion/affect_behav	1.33366503
35	MP0003121_genomic_imprinting	1.32579989
36	MP0000049_abnormal_middle_ear	1.32091537
37	MP0003937_abnormal_limbs/digits/tail_de	1.28252244
38	MP0005394_taste/olfaction_phenotype	1.27873402
39	MP0005499_abnormal_olfactory_system	1.27873402
40	MP0005257_abnormal_intraocular_pressure	1.27248363
41	MP0001293_anophthalmia	1.26549850
42	MP0004147_increased_porphyrin_level	1.21964889
43	MP0003385_abnormal_body_wall	1.21615372
44	MP0004858_abnormal_nervous_system	1.20879066
45	MP0002638_abnormal_pupillary_reflex	1.20393443
46	MP0000631_abnormal_neuroendocrine_gland	1.16374295
47	MP0003878_abnormal_ear_physiology	1.13994304
48	MP0005377_hearing/vestibular/ear_phenot	1.13994304
49	MP0002733_abnormal_thermal_nociception	1.10275380
50	MP0002233_abnormal_nose_morphology	1.10198874
51	MP0005410_abnormal_fertilization	1.09591364
52	MP0003329_amyloid_beta_deposits	1.06989138
53	MP0002081_perinatal_lethality	1.06756061
54	MP0003283_abnormal_digestive_organ	1.05757830
55	MP0000516_abnormal_urinary_system	1.05143930
56	MP0005367_renal/urinary_system_phenotyp	1.05143930
57	MP0002752_abnormal_somatic_nervous	1.04062133
58	MP0003698_abnormal_male_reproductive	1.03835509
59	MP0003890_abnormal_embryonic-extraembry	1.02059968
60	MP0002064_seizures	1.01824331
61	MP0003183_abnormal_peptide_metabolism	1.01813214
62	MP0009379_abnormal_foot_pigmentation	1.01792371
63	MP0006292_abnormal_olfactory_placode	1.01711691
64	MP0001970_abnormal_pain_threshold	1.01462487
65	MP0001299_abnormal_eye_distance/	1.01051621
66	MP0002092_abnormal_eye_morphology	1.00232167
67	MP0009745_abnormal_behavioral_response	0.99199814
68	MP0003935_abnormal_craniofacial_develop	0.98838520
69	MP0003938_abnormal_ear_development	0.98645710
70	MP0001286_abnormal_eye_development	0.97962050
71	MP0002909_abnormal_adrenal_gland	0.97906777
72	MP0003567_abnormal_fetal_cardiomyocyte	0.96118826
73	MP0005187_abnormal_penis_morphology	0.95414880
74	MP0002272_abnormal_nervous_system	0.93427620
75	MP0005645_abnormal_hypothalamus_physiol	0.93341435
76	MP0002084_abnormal_developmental_patter	0.93052510
77	MP0003942_abnormal_urinary_system	0.92684973
78	MP0004924_abnormal_behavior	0.92611774
79	MP0005386_behavior/neurological_phenoty	0.92611774
80	MP0002067_abnormal_sensory_capabilities	0.92495725
81	MP0000026_abnormal_inner_ear	0.92128687
82	MP0002653_abnormal_ependyma_morphology	0.90097314
83	MP0002085_abnormal_embryonic_tissue	0.89627481
84	MP0000428_abnormal_craniofacial_morphol	0.89165901
85	MP0000462_abnormal_digestive_system	0.87421949
86	MP0002082_postnatal_lethality	0.87288491
87	MP0010770_preweaning_lethality	0.87288491
88	MP0009053_abnormal_anal_canal	0.86874963
89	MP0001440_abnormal_grooming_behavior	0.86695388
90	MP0005670_abnormal_white_adipose	0.86253329
91	MP0002069_abnormal_eating/drinking_beha	0.86065369
92	MP0002116_abnormal_craniofacial_bone	0.84395537
93	MP0003115_abnormal_respiratory_system	0.82788954
94	MP0005391_vision/eye_phenotype	0.82037196
95	MP0003755_abnormal_palate_morphology	0.81831255
96	MP0010769_abnormal_survival	0.81574630
97	MP0008789_abnormal_olfactory_epithelium	0.81551402
98	MP0004264_abnormal_extraembryonic_tissu	0.80960695
99	MP0004885_abnormal_endolymph	0.80765399
100	MP0001502_abnormal_circadian_rhythm	0.80198945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatoblastoma (HP:0002884)	3.17121210
2	Renovascular hypertension (HP:0100817)	3.03109163
3	High anterior hairline (HP:0009890)	2.97040777
4	Cortical dysplasia (HP:0002539)	2.84060494
5	Drooling (HP:0002307)	2.74933856
6	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.65119272
7	Short 4th metacarpal (HP:0010044)	2.65119272
8	Focal motor seizures (HP:0011153)	2.64847667
9	Myokymia (HP:0002411)	2.63441789
10	Hyperacusis (HP:0010780)	2.59304776
11	Cutaneous finger syndactyly (HP:0010554)	2.49664365
12	Excessive salivation (HP:0003781)	2.45896535
13	Cutaneous syndactyly (HP:0012725)	2.36081998
14	Amblyopia (HP:0000646)	2.29707713
15	Abnormality of the 4th metacarpal (HP:0010012)	2.29421212
16	Abnormality of the aortic arch (HP:0012303)	2.25453858
17	Intestinal atresia (HP:0011100)	2.22157920
18	Insidious onset (HP:0003587)	2.21518404
19	Termporal pattern (HP:0011008)	2.21518404
20	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.17220517
21	Hypoplasia of the brainstem (HP:0002365)	2.17220517
22	Obsessive-compulsive behavior (HP:0000722)	2.14288222
23	Elfin facies (HP:0004428)	2.13660974
24	Overriding aorta (HP:0002623)	2.13336951
25	Exotropia (HP:0000577)	2.12792831
26	Insomnia (HP:0100785)	2.10996832
27	Vitreoretinal degeneration (HP:0000655)	2.09007148
28	Abnormality of the lower motor neuron (HP:0002366)	2.06683160
29	Limb dystonia (HP:0002451)	2.03289855
30	Impulsivity (HP:0100710)	2.02636184
31	Midline defect of the nose (HP:0004122)	2.00841513
32	Increased nuchal translucency (HP:0010880)	2.00832437
33	Omphalocele (HP:0001539)	1.99223534
34	Generalized hypotonia (HP:0001290)	1.96676377
35	Ankle clonus (HP:0011448)	1.94897261
36	Abnormality of the parathyroid morphology (HP:0011766)	1.94775658
37	Epileptic encephalopathy (HP:0200134)	1.91385356
38	Megalencephaly (HP:0001355)	1.90716627
39	Focal seizures (HP:0007359)	1.90465236
40	Trigonocephaly (HP:0000243)	1.90400970
41	Renal hypoplasia (HP:0000089)	1.90284160
42	Hyperventilation (HP:0002883)	1.89469372
43	Large earlobe (HP:0009748)	1.89160348
44	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.88528722
45	Turricephaly (HP:0000262)	1.88277986
46	Oligodactyly (HP:0012165)	1.88242182
47	Bicornuate uterus (HP:0000813)	1.85997894
48	Abnormality of the diencephalon (HP:0010662)	1.85718513
49	Wide cranial sutures (HP:0010537)	1.83659776
50	Oligodactyly (hands) (HP:0001180)	1.83289119
51	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.83056098
52	Intellectual disability, moderate (HP:0002342)	1.82626897
53	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.82396521
54	Renal duplication (HP:0000075)	1.80149309
55	Abnormality of the phalanges of the hallux (HP:0010057)	1.79891227
56	Megalocornea (HP:0000485)	1.76388005
57	Morphological abnormality of the middle ear (HP:0008609)	1.76378085
58	Shawl scrotum (HP:0000049)	1.76330529
59	Neonatal short-limb short stature (HP:0008921)	1.74499537
60	Tubulointerstitial nephritis (HP:0001970)	1.74055509
61	Esophageal atresia (HP:0002032)	1.72282673
62	Abnormality of the corticospinal tract (HP:0002492)	1.72256131
63	Impaired vibration sensation in the lower limbs (HP:0002166)	1.71180194
64	Pheochromocytoma (HP:0002666)	1.70583511
65	Sacral dimple (HP:0000960)	1.68001633
66	Polyphagia (HP:0002591)	1.67420063
67	Papillary thyroid carcinoma (HP:0002895)	1.65350051
68	Abnormality of the ischium (HP:0003174)	1.65316459
69	Spina bifida occulta (HP:0003298)	1.65257853
70	Medulloblastoma (HP:0002885)	1.64589563
71	Hypopigmentation of the fundus (HP:0007894)	1.63145012
72	Broad-based gait (HP:0002136)	1.62412385
73	Precocious puberty (HP:0000826)	1.61723070
74	Amyotrophic lateral sclerosis (HP:0007354)	1.59489149
75	Urinary urgency (HP:0000012)	1.57532204
76	Lissencephaly (HP:0001339)	1.57474254
77	Myelomeningocele (HP:0002475)	1.57328485
78	Failure to thrive in infancy (HP:0001531)	1.56325912
79	Aqueductal stenosis (HP:0002410)	1.55803226
80	Truncal obesity (HP:0001956)	1.55075004
81	Hypoventilation (HP:0002791)	1.55018614
82	Anophthalmia (HP:0000528)	1.53922232
83	Action tremor (HP:0002345)	1.53516043
84	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.53152862
85	Alacrima (HP:0000522)	1.51993496
86	Bronchomalacia (HP:0002780)	1.51769354
87	Abnormality of the intervertebral disk (HP:0005108)	1.51548662
88	Pachygyria (HP:0001302)	1.50740032
89	Spastic gait (HP:0002064)	1.50551516
90	Neoplasm of the oral cavity (HP:0100649)	1.50249069
91	Progressive sensorineural hearing impairment (HP:0000408)	1.49874788
92	Hammertoe (HP:0001765)	1.49772579
93	Vertebral arch anomaly (HP:0008438)	1.49657727
94	Arnold-Chiari malformation (HP:0002308)	1.49517673
95	Urinary bladder sphincter dysfunction (HP:0002839)	1.49472175
96	Hypoplasia of the corpus callosum (HP:0002079)	1.49395370
97	Volvulus (HP:0002580)	1.48108851
98	Wide anterior fontanel (HP:0000260)	1.47658736
99	Partial duplication of thumb phalanx (HP:0009944)	1.47092681
100	Shoulder girdle muscle weakness (HP:0003547)	1.47004973

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.51302805
2	MARK1	5.30605934
3	MAP3K10	2.93187087
4	MAP3K4	2.47000610
5	NTRK2	2.19500050
6	BCR	2.10751044
7	DYRK2	2.09790044
8	NTRK1	2.06112300
9	TNIK	2.05304862
10	MAP2K7	2.03979644
11	TYRO3	2.01508324
12	EPHA4	1.97491307
13	SIK2	1.97195732
14	EPHB2	1.91183175
15	BRD4	1.82905684
16	PLK4	1.67714935
17	LATS2	1.61601379
18	ICK	1.58550609
19	CDK12	1.48045667
20	PNCK	1.46695644
21	WNK3	1.46077532
22	DDR2	1.44687983
23	CAMK1G	1.35240219
24	EEF2K	1.31474476
25	DYRK1B	1.29875967
26	MKNK1	1.28902824
27	CSNK1G2	1.28225754
28	EPHA3	1.17392489
29	PRKD3	1.16389039
30	MKNK2	1.11076265
31	RIPK1	1.05840312
32	CSNK1G3	1.04082338
33	NTRK3	1.03600689
34	MINK1	1.03526948
35	PDGFRA	1.03419325
36	NEK2	1.02499580
37	CSNK1G1	0.99365311
38	FGFR2	0.98076156
39	CSNK1A1L	0.97298135
40	CDK19	0.94994509
41	STK38L	0.93190871
42	PLK2	0.90136793
43	MAP2K4	0.89891515
44	INSRR	0.89306423
45	UHMK1	0.85886194
46	TESK1	0.85630836
47	CCNB1	0.84468724
48	LATS1	0.84437257
49	CDK5	0.82565392
50	MET	0.81739345
51	RET	0.80577908
52	SGK494	0.80111989
53	SGK223	0.80111989
54	DYRK1A	0.79902350
55	SRPK1	0.76606634
56	MAPK13	0.74040621
57	AKT3	0.71424206
58	ERBB2	0.70853844
59	PRKCZ	0.70656192
60	MTOR	0.70296484
61	KSR1	0.69746346
62	CAMK1D	0.68621008
63	CDC7	0.67888440
64	PRKCG	0.66692229
65	CDK11A	0.65707679
66	CDK14	0.61373182
67	CDK18	0.61273888
68	DYRK3	0.60562497
69	CDK15	0.60365120
70	SGK2	0.59072713
71	TRIM28	0.56822109
72	GSK3B	0.55618795
73	PKN1	0.54497359
74	LMTK2	0.54441695
75	RPS6KA2	0.54339361
76	CDK2	0.53856465
77	CSNK1E	0.53712067
78	MAP4K2	0.52739169
79	MST1R	0.49921973
80	CDK1	0.49901109
81	MARK2	0.48416594
82	MAPK10	0.48412374
83	STK39	0.48086009
84	CSNK1D	0.47538014
85	ALK	0.46453328
86	TRIB3	0.42871727
87	ERBB3	0.42144884
88	MAP3K6	0.41422239
89	TIE1	0.41342652
90	MAPK9	0.40636937
91	PRKDC	0.38300584
92	ACVR1B	0.38229519
93	PHKG1	0.36590559
94	PHKG2	0.36590559
95	CHEK2	0.34950041
96	MAPK14	0.34283865
97	CDK3	0.34245974
98	ATM	0.33867558
99	MAPK8	0.33315690
100	PRKAA1	0.32447423

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.60393192
2	Axon guidance_Homo sapiens_hsa04360	2.16169030
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.09761712
4	Cocaine addiction_Homo sapiens_hsa05030	1.81211460
5	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.78865033
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72424528
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.71097074
8	Glutamatergic synapse_Homo sapiens_hsa04724	1.69917848
9	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.61954642
10	Protein digestion and absorption_Homo sapiens_hsa04974	1.61098483
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.57931921
12	Gap junction_Homo sapiens_hsa04540	1.56117648
13	Circadian entrainment_Homo sapiens_hsa04713	1.52953653
14	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.50344852
15	Dopaminergic synapse_Homo sapiens_hsa04728	1.49044272
16	Basal cell carcinoma_Homo sapiens_hsa05217	1.48761066
17	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.45002537
18	GABAergic synapse_Homo sapiens_hsa04727	1.43572079
19	Cholinergic synapse_Homo sapiens_hsa04725	1.42892407
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.42864815
21	Hippo signaling pathway_Homo sapiens_hsa04390	1.39647158
22	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.35603520
23	Alcoholism_Homo sapiens_hsa05034	1.33587499
24	Renin-angiotensin system_Homo sapiens_hsa04614	1.32867817
25	Taste transduction_Homo sapiens_hsa04742	1.31082402
26	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.28006360
27	Adherens junction_Homo sapiens_hsa04520	1.26377693
28	Endometrial cancer_Homo sapiens_hsa05213	1.20866413
29	Bile secretion_Homo sapiens_hsa04976	1.19335034
30	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.19207261
31	Long-term depression_Homo sapiens_hsa04730	1.17585999
32	ErbB signaling pathway_Homo sapiens_hsa04012	1.17198615
33	Amphetamine addiction_Homo sapiens_hsa05031	1.15976971
34	Tight junction_Homo sapiens_hsa04530	1.15948728
35	Melanogenesis_Homo sapiens_hsa04916	1.15445815
36	Morphine addiction_Homo sapiens_hsa05032	1.14933863
37	Colorectal cancer_Homo sapiens_hsa05210	1.14204957
38	Notch signaling pathway_Homo sapiens_hsa04330	1.13264183
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.12982556
40	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.11683750
41	Long-term potentiation_Homo sapiens_hsa04720	1.08198430
42	Wnt signaling pathway_Homo sapiens_hsa04310	1.03085735
43	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.01899071
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.00067862
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.00046546
46	Type II diabetes mellitus_Homo sapiens_hsa04930	0.99753303
47	mRNA surveillance pathway_Homo sapiens_hsa03015	0.99499802
48	Insulin secretion_Homo sapiens_hsa04911	0.97982557
49	Lysine degradation_Homo sapiens_hsa00310	0.96374137
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.96310179
51	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.93200359
52	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.88826399
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86961610
54	Oocyte meiosis_Homo sapiens_hsa04114	0.86259012
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.85835435
56	AMPK signaling pathway_Homo sapiens_hsa04152	0.83940355
57	Choline metabolism in cancer_Homo sapiens_hsa05231	0.80814069
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79768994
59	Serotonergic synapse_Homo sapiens_hsa04726	0.79312022
60	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.78006680
61	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.76384069
62	Butanoate metabolism_Homo sapiens_hsa00650	0.74164130
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.73523558
64	Arginine biosynthesis_Homo sapiens_hsa00220	0.73343609
65	MicroRNAs in cancer_Homo sapiens_hsa05206	0.72170142
66	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.71984014
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.71006385
68	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.69830432
69	Glioma_Homo sapiens_hsa05214	0.68155621
70	Olfactory transduction_Homo sapiens_hsa04740	0.67848088
71	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66566551
72	Renin secretion_Homo sapiens_hsa04924	0.66295203
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65087663
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.64723555
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64293106
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.64040247
77	Gastric acid secretion_Homo sapiens_hsa04971	0.62083748
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.61675786
79	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.61623147
80	Salivary secretion_Homo sapiens_hsa04970	0.60793573
81	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.59991037
82	Cell cycle_Homo sapiens_hsa04110	0.59439130
83	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.59050561
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.58757006
85	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.57473840
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.57076566
87	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.56019624
88	Thyroid cancer_Homo sapiens_hsa05216	0.55652081
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55546138
90	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55185393
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.54819798
92	Prolactin signaling pathway_Homo sapiens_hsa04917	0.54220307
93	Renal cell carcinoma_Homo sapiens_hsa05211	0.54140908
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53500454
95	Phototransduction_Homo sapiens_hsa04744	0.52635218
96	Insulin signaling pathway_Homo sapiens_hsa04910	0.49744331
97	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.48913637
98	Pancreatic secretion_Homo sapiens_hsa04972	0.47567606
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47071314
100	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.46450046

KIAA1211

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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