KIAA1211L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)8.78235329
2motile cilium assembly (GO:0044458)8.51596327
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.54177398
4epithelial cilium movement (GO:0003351)7.21294493
5synaptic vesicle docking involved in exocytosis (GO:0016081)6.36399709
6axoneme assembly (GO:0035082)5.84942263
7synaptic vesicle maturation (GO:0016188)5.69028283
8glutamate secretion (GO:0014047)5.47731813
9left/right pattern formation (GO:0060972)5.25761004
10synaptic vesicle exocytosis (GO:0016079)5.05782034
11primary alcohol catabolic process (GO:0034310)4.78563099
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.78528987
13regulation of synaptic vesicle exocytosis (GO:2000300)4.64035609
14vitamin transmembrane transport (GO:0035461)4.34949075
15microtubule bundle formation (GO:0001578)4.24204704
16regulation of cilium movement (GO:0003352)4.15591170
17negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.14813911
18cellular potassium ion homeostasis (GO:0030007)4.14802937
19ventricular system development (GO:0021591)4.10116121
20neurotransmitter secretion (GO:0007269)4.09191818
21ethanol metabolic process (GO:0006067)4.05242255
22lung epithelium development (GO:0060428)3.94098591
23cerebellar granule cell differentiation (GO:0021707)3.90996925
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89438673
25sodium ion export (GO:0071436)3.88556916
26regulation of synaptic vesicle transport (GO:1902803)3.85406295
27one-carbon compound transport (GO:0019755)3.81743178
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77945669
29diterpenoid biosynthetic process (GO:0016102)3.74536356
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64538452
31regulation of ARF protein signal transduction (GO:0032012)3.64276704
32negative regulation of inclusion body assembly (GO:0090084)3.61525422
33regulation of neuronal synaptic plasticity (GO:0048168)3.59829811
34L-amino acid import (GO:0043092)3.55414895
35left/right axis specification (GO:0070986)3.54841686
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.53631833
37vocalization behavior (GO:0071625)3.52138996
38sperm capacitation (GO:0048240)3.44473285
39potassium ion homeostasis (GO:0055075)3.43024550
40locomotory exploration behavior (GO:0035641)3.35565115
41protein localization to cilium (GO:0061512)3.31196318
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.30972336
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.27129293
44positive regulation of synapse maturation (GO:0090129)3.25983381
45negative regulation of dendrite morphogenesis (GO:0050774)3.22870046
46neurotransmitter transport (GO:0006836)3.20282312
47ethanol oxidation (GO:0006069)3.20214466
48regulation of neurotransmitter levels (GO:0001505)3.16217573
49regulation of voltage-gated calcium channel activity (GO:1901385)3.14483682
50regulation of interleukin-5 production (GO:0032674)3.10029235
51regulation of microtubule-based movement (GO:0060632)3.09673016
52amino acid import (GO:0043090)3.08901027
53microtubule-based movement (GO:0007018)3.07596096
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04149854
55cilium organization (GO:0044782)3.03591549
56regulation of interleukin-13 production (GO:0032656)3.03006500
57apical protein localization (GO:0045176)3.02410805
58regulation of synaptic plasticity (GO:0048167)3.01266782
59intraciliary transport (GO:0042073)3.01050742
60negative regulation of B cell mediated immunity (GO:0002713)3.00427913
61negative regulation of immunoglobulin mediated immune response (GO:0002890)3.00427913
62cilium assembly (GO:0042384)2.97410688
63exploration behavior (GO:0035640)2.95498947
64sodium ion homeostasis (GO:0055078)2.89313665
65synaptic transmission, glutamatergic (GO:0035249)2.88078483
66positive regulation of membrane potential (GO:0045838)2.79640061
67cellular sodium ion homeostasis (GO:0006883)2.78855418
68neuronal ion channel clustering (GO:0045161)2.77618051
69regulation of vesicle fusion (GO:0031338)2.76807352
70pyrimidine-containing compound transmembrane transport (GO:0072531)2.76580909
71peptidyl-tyrosine autophosphorylation (GO:0038083)2.71174271
72regulation of germinal center formation (GO:0002634)2.70337158
73establishment of apical/basal cell polarity (GO:0035089)2.68774750
74chemosensory behavior (GO:0007635)2.68471723
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68220825
76positive regulation of neurotransmitter secretion (GO:0001956)2.66449812
77regulation of neurotransmitter secretion (GO:0046928)2.65170110
78regulation of cell communication by electrical coupling (GO:0010649)2.63949837
79phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63472911
80cytoplasmic microtubule organization (GO:0031122)2.59783625
81positive regulation of neurotransmitter transport (GO:0051590)2.59670565
82potassium ion import (GO:0010107)2.58152137
83response to xenobiotic stimulus (GO:0009410)2.57744097
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.57214420
85tolerance induction (GO:0002507)2.54979235
86detection of calcium ion (GO:0005513)2.53775225
87cellular component assembly involved in morphogenesis (GO:0010927)2.52836627
88neuromuscular process controlling balance (GO:0050885)2.52366525
89positive regulation of vesicle fusion (GO:0031340)2.52216285
90neuron-neuron synaptic transmission (GO:0007270)2.51585028
91regulation of synapse maturation (GO:0090128)2.51276074
92regulation of synapse structural plasticity (GO:0051823)2.51256771
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51143875
94glomerular epithelial cell development (GO:0072310)2.50438114
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49555070
96dendritic spine morphogenesis (GO:0060997)2.48439763
97regulation of glutamate receptor signaling pathway (GO:1900449)2.47912067
98dendritic spine organization (GO:0097061)2.47820607
99axonemal dynein complex assembly (GO:0070286)12.3987897
100cilium or flagellum-dependent cell motility (GO:0001539)10.1965121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DROSHA_22980978_ChIP-Seq_HELA_Human3.78349379
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.17991441
3ESR2_21235772_ChIP-Seq_MCF-7_Human2.47633039
4TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.33558109
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21048750
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20304326
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17240584
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.16548880
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08514720
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06643444
11REST_21632747_ChIP-Seq_MESCs_Mouse2.00700053
12MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99236032
13EZH2_27294783_Chip-Seq_ESCs_Mouse1.96527110
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.93689392
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93609355
16TRIM28_21343339_ChIP-Seq_HEK293_Human1.92770761
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89421786
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88964992
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87949009
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85449934
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80052357
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.65556088
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.65165373
24SMC4_20622854_ChIP-Seq_HELA_Human1.63763899
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57321940
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57321940
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57089232
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56419870
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55456344
30LXR_22292898_ChIP-Seq_THP-1_Human1.55262065
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55038895
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.52773781
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51593808
34CTCF_27219007_Chip-Seq_Bcells_Human1.48489210
35KDM2B_26808549_Chip-Seq_K562_Human1.45507539
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43834857
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42841240
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41435657
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40933571
40EZH2_22144423_ChIP-Seq_EOC_Human1.40503968
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.38242356
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37879917
43AHR_22903824_ChIP-Seq_MCF-7_Human1.36738320
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.36133183
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31255266
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28260289
47CREB1_26743006_Chip-Seq_LNCaP_Human1.28160947
48TET1_21490601_ChIP-Seq_MESCs_Mouse1.27345774
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27159864
50RACK7_27058665_Chip-Seq_MCF-7_Human1.24864724
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24612675
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21768797
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19848488
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19327913
55P68_20966046_ChIP-Seq_HELA_Human1.17326220
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.16077089
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15359239
58TP63_22573176_ChIP-Seq_HFKS_Human1.14706438
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.14066589
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13583400
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12041904
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11551205
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.10532736
64RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09141144
65KLF5_25053715_ChIP-Seq_YYC3_Human1.07853175
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.07208459
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06922266
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03843617
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03822217
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02709340
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02654775
72SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95873371
73AR_19668381_ChIP-Seq_PC3_Human0.95634667
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95022159
75SOX2_20726797_ChIP-Seq_SW620_Human0.95008147
76AR_21572438_ChIP-Seq_LNCaP_Human0.94277834
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93960844
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93047345
79SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92233503
80FOXA2_19822575_ChIP-Seq_HepG2_Human0.92208136
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90430319
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89009530
83TP63_17297297_ChIP-ChIP_HaCaT_Human0.88451578
84OCT4_19829295_ChIP-Seq_ESCs_Human0.88234135
85PIAS1_25552417_ChIP-Seq_VCAP_Human0.88210904
86RING1B_27294783_Chip-Seq_ESCs_Mouse0.87145545
87P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87105157
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86770087
89CTCF_20526341_ChIP-Seq_ESCs_Human0.86700004
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84867335
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84001634
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83260127
93GATA1_19941826_ChIP-Seq_K562_Human0.83123827
94KLF4_19829295_ChIP-Seq_ESCs_Human0.82802953
95TP53_23651856_ChIP-Seq_MEFs_Mouse0.82516573
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.82472403
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81241516
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.81029916
99STAT1_20625510_ChIP-Seq_HELA_Human0.80943891
100MYC_27129775_Chip-Seq_CORNEA_Mouse0.80448526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.70508106
2MP0009780_abnormal_chondrocyte_physiolo4.41879628
3MP0003880_abnormal_central_pattern3.92876059
4MP0004270_analgesia3.73357264
5MP0008875_abnormal_xenobiotic_pharmacok3.33377281
6MP0003635_abnormal_synaptic_transmissio3.12960475
7MP0002064_seizures3.09374846
8MP0002653_abnormal_ependyma_morphology2.80268704
9MP0002734_abnormal_mechanical_nocicepti2.79821456
10MP0009745_abnormal_behavioral_response2.79649593
11MP0009046_muscle_twitch2.71251697
12MP0001984_abnormal_olfaction2.58524858
13MP0002063_abnormal_learning/memory/cond2.53948619
14MP0005423_abnormal_somatic_nervous2.43704446
15MP0010234_abnormal_vibrissa_follicle2.38633279
16MP0001486_abnormal_startle_reflex2.38503105
17MP0004043_abnormal_pH_regulation2.37174973
18MP0002272_abnormal_nervous_system2.34746459
19MP0003879_abnormal_hair_cell2.26783198
20MP0002572_abnormal_emotion/affect_behav2.22230042
21MP0001501_abnormal_sleep_pattern2.15831042
22MP0005623_abnormal_meninges_morphology1.97696692
23MP0001968_abnormal_touch/_nociception1.97629155
24MP0003329_amyloid_beta_deposits1.95751974
25MP0002735_abnormal_chemical_nociception1.94965782
26MP0008569_lethality_at_weaning1.71772263
27MP0001970_abnormal_pain_threshold1.70760865
28MP0002132_abnormal_respiratory_system1.67503908
29MP0000566_synostosis1.67051868
30MP0002909_abnormal_adrenal_gland1.64324001
31MP0001765_abnormal_ion_homeostasis1.58832339
32MP0003075_altered_response_to1.58517669
33MP0001346_abnormal_lacrimal_gland1.55671583
34MP0001502_abnormal_circadian_rhythm1.50612143
35MP0003633_abnormal_nervous_system1.47132373
36MP0005646_abnormal_pituitary_gland1.45320680
37MP0004133_heterotaxia1.39810263
38MP0003690_abnormal_glial_cell1.37466071
39MP0010678_abnormal_skin_adnexa1.31386421
40MP0004885_abnormal_endolymph1.26572923
41MP0002733_abnormal_thermal_nociception1.25562102
42MP0004811_abnormal_neuron_physiology1.22648324
43MP0002557_abnormal_social/conspecific_i1.22430903
44MP0002277_abnormal_respiratory_mucosa1.21869252
45MP0002736_abnormal_nociception_after1.21198630
46MP0002067_abnormal_sensory_capabilities1.20652803
47MP0005409_darkened_coat_color1.19612281
48MP0003631_nervous_system_phenotype1.18501765
49MP0000920_abnormal_myelination1.17715088
50MP0002066_abnormal_motor_capabilities/c1.17714689
51MP0001485_abnormal_pinna_reflex1.16262648
52MP0001440_abnormal_grooming_behavior1.14095341
53MP0004019_abnormal_vitamin_homeostasis1.13735868
54MP0000383_abnormal_hair_follicle1.12532778
55MP0003634_abnormal_glial_cell1.11881802
56MP0003878_abnormal_ear_physiology1.10736016
57MP0005377_hearing/vestibular/ear_phenot1.10736016
58MP0002229_neurodegeneration1.10653643
59MP0000678_abnormal_parathyroid_gland1.06857825
60MP0002882_abnormal_neuron_morphology1.04842043
61MP0002822_catalepsy0.96999139
62MP0002168_other_aberrant_phenotype0.95740621
63MP0008789_abnormal_olfactory_epithelium0.95559555
64MP0005499_abnormal_olfactory_system0.93349114
65MP0005394_taste/olfaction_phenotype0.93349114
66MP0000955_abnormal_spinal_cord0.92488258
67MP0005165_increased_susceptibility_to0.90653825
68MP0005166_decreased_susceptibility_to0.90462731
69MP0002249_abnormal_larynx_morphology0.89646268
70MP0001963_abnormal_hearing_physiology0.88832128
71MP0003183_abnormal_peptide_metabolism0.88025718
72MP0003123_paternal_imprinting0.87875139
73MP0001905_abnormal_dopamine_level0.86935493
74MP0003045_fibrosis0.85505005
75MP0008874_decreased_physiological_sensi0.85278664
76MP0003172_abnormal_lysosome_physiology0.82615055
77MP0000681_abnormal_thyroid_gland0.81936808
78MP0004924_abnormal_behavior0.80149802
79MP0005386_behavior/neurological_phenoty0.80149802
80MP0002876_abnormal_thyroid_physiology0.79237167
81MP0003632_abnormal_nervous_system0.78318625
82MP0003787_abnormal_imprinting0.78205941
83MP0000604_amyloidosis0.78193769
84MP0008872_abnormal_physiological_respon0.77510940
85MP0002638_abnormal_pupillary_reflex0.76976736
86MP0001177_atelectasis0.75613966
87MP0002152_abnormal_brain_morphology0.72205515
88MP0002160_abnormal_reproductive_system0.72022701
89MP0005636_abnormal_mineral_homeostasis0.71352737
90MP0001664_abnormal_digestion0.71210266
91MP0001849_ear_inflammation0.69337941
92MP0004742_abnormal_vestibular_system0.65525833
93MP0001188_hyperpigmentation0.63977944
94MP0005535_abnormal_body_temperature0.58581094
95MP0005551_abnormal_eye_electrophysiolog0.58129704
96MP0005388_respiratory_system_phenotype0.58016014
97MP0002133_abnormal_respiratory_system0.58016014
98MP0002069_abnormal_eating/drinking_beha0.57798334
99MP0003303_peritoneal_inflammation0.57042849
100MP0002184_abnormal_innervation0.55247267

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.61841029
2Abnormal respiratory motile cilium morphology (HP:0005938)9.61841029
3Abnormal respiratory motile cilium physiology (HP:0012261)9.41071683
4Absent/shortened dynein arms (HP:0200106)9.37491173
5Dynein arm defect of respiratory motile cilia (HP:0012255)9.37491173
6Abnormal ciliary motility (HP:0012262)9.21802003
7Rhinitis (HP:0012384)8.71754955
8Chronic bronchitis (HP:0004469)6.89781080
9Bronchiectasis (HP:0002110)6.33014721
10Nasal polyposis (HP:0100582)6.04299811
11Abnormality of the nasal mucosa (HP:0000433)5.13732136
12Infertility (HP:0000789)3.76206569
13Male infertility (HP:0003251)3.65693095
14Bronchitis (HP:0012387)3.64547793
15Recurrent sinusitis (HP:0011108)3.61834264
16Myokymia (HP:0002411)3.60218673
17Recurrent otitis media (HP:0000403)3.46410348
18Chronic sinusitis (HP:0011109)3.30093958
19Hyperactive renin-angiotensin system (HP:0000841)3.24006300
20Atelectasis (HP:0100750)3.02800672
21Obstructive sleep apnea (HP:0002870)2.99129509
22Focal motor seizures (HP:0011153)2.96505399
23Occipital encephalocele (HP:0002085)2.75811871
24Focal seizures (HP:0007359)2.58635272
25Chronic otitis media (HP:0000389)2.53214399
26Epileptic encephalopathy (HP:0200134)2.49649216
27Ankle clonus (HP:0011448)2.45400248
28Supranuclear gaze palsy (HP:0000605)2.33832303
29Cystic liver disease (HP:0006706)2.27066331
30Action tremor (HP:0002345)2.24799582
31Pancreatic fibrosis (HP:0100732)2.18491369
32Febrile seizures (HP:0002373)2.16881572
33Torticollis (HP:0000473)2.16523522
34True hermaphroditism (HP:0010459)2.16377558
35Renal salt wasting (HP:0000127)2.12515584
36Papilledema (HP:0001085)2.10284726
37Bell-shaped thorax (HP:0001591)2.07482450
38Ventricular fibrillation (HP:0001663)2.03630960
39Neurofibrillary tangles (HP:0002185)2.00087783
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8547474
41Visual hallucinations (HP:0002367)1.99746672
42Hand muscle atrophy (HP:0009130)1.94532349
43Hyperaldosteronism (HP:0000859)1.93280450
44Atonic seizures (HP:0010819)1.91535833
45Abnormality of renin-angiotensin system (HP:0000847)1.86927745
46Decreased circulating renin level (HP:0003351)1.85785384
47Hyperkalemia (HP:0002153)1.84630981
48Diplopia (HP:0000651)1.82103254
49Abnormality of binocular vision (HP:0011514)1.82103254
50Nephronophthisis (HP:0000090)1.81112393
51Depression (HP:0000716)1.77521912
52Postural instability (HP:0002172)1.76582883
53Sleep apnea (HP:0010535)1.75138250
54Upper limb amyotrophy (HP:0009129)1.74429153
55Distal upper limb amyotrophy (HP:0007149)1.74429153
56Focal dystonia (HP:0004373)1.72837385
57Fetal akinesia sequence (HP:0001989)1.68626726
58Neuronal loss in central nervous system (HP:0002529)1.66683024
59Craniofacial dystonia (HP:0012179)1.64467259
60Tubulointerstitial nephritis (HP:0001970)1.64386278
61Molar tooth sign on MRI (HP:0002419)1.64268453
62Abnormality of midbrain morphology (HP:0002418)1.64268453
63Spastic gait (HP:0002064)1.62617422
64Abnormality of chloride homeostasis (HP:0011422)1.61282724
65Absent frontal sinuses (HP:0002688)1.60247498
66Annular pancreas (HP:0001734)1.58486592
67Spinal cord compression (HP:0002176)1.53162376
68Hypokalemic alkalosis (HP:0001949)1.52717993
69Postaxial foot polydactyly (HP:0001830)1.51837590
70Urinary urgency (HP:0000012)1.51019546
71Truncal ataxia (HP:0002078)1.48926305
72Cerebral inclusion bodies (HP:0100314)1.48836539
73Stridor (HP:0010307)1.48560970
74Generalized tonic-clonic seizures (HP:0002069)1.47919206
75Pancreatic cysts (HP:0001737)1.47330237
76Intention tremor (HP:0002080)1.46942063
77Tetraplegia (HP:0002445)1.46501987
78Abnormality of permanent molar morphology (HP:0011071)1.45916092
79Abnormality of the dental root (HP:0006486)1.45916092
80Taurodontia (HP:0000679)1.45916092
81Absent speech (HP:0001344)1.45075282
82Dysmetria (HP:0001310)1.44846816
83Glucose intolerance (HP:0000833)1.43319090
84Nephropathy (HP:0000112)1.42935059
85Akinesia (HP:0002304)1.42676420
86Gait imbalance (HP:0002141)1.41915841
87Recurrent bronchitis (HP:0002837)1.40949908
88Absence seizures (HP:0002121)1.40376112
89Chronic hepatic failure (HP:0100626)1.39997357
90Progressive cerebellar ataxia (HP:0002073)1.39470360
91Adrenal overactivity (HP:0002717)1.39346892
92Abnormality of the renal medulla (HP:0100957)1.35175151
93Abnormal eating behavior (HP:0100738)1.33942524
94Abnormality of molar (HP:0011077)1.32594000
95Abnormality of molar morphology (HP:0011070)1.32594000
96Distal lower limb muscle weakness (HP:0009053)1.31862243
97Dialeptic seizures (HP:0011146)1.31576534
98Asplenia (HP:0001746)1.30366185
99Lower limb asymmetry (HP:0100559)1.29442837
100Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.29263593

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.96991656
2EPHA44.82759558
3EPHA23.28921219
4NTRK33.10168048
5PAK62.90623416
6DAPK22.71446800
7CAMKK12.46644186
8RIPK42.37832396
9MST42.34709738
10MAP3K22.28006869
11PRKD31.96486508
12RIPK11.96302733
13UHMK11.91963755
14MAP3K91.76804569
15NEK61.69762381
16MINK11.54977388
17NTRK11.45949919
18MARK21.44210464
19STK381.42502284
20TESK11.30100088
21ARAF1.28620679
22MARK11.22817088
23MAPKAPK31.20414517
24KSR21.19432227
25MST1R1.18770698
26NME11.18134714
27SMG11.14121760
28NTRK21.12624853
29LATS21.11659763
30DAPK11.11443274
31CDK51.09019623
32GRK51.07293474
33MAP3K121.04143681
34TRIB31.03000352
35BMPR21.02640924
36CAMK10.99863654
37PTK2B0.98656145
38SGK2230.93308053
39SGK4940.93308053
40PRKCH0.92702763
41CAMK2G0.91113328
42PDPK10.90600589
43LMTK20.90399733
44CDK190.86107762
45OXSR10.85295182
46MAP3K130.82950727
47SGK10.82176981
48EEF2K0.80329996
49CAMK2B0.79864277
50PHKG20.76928386
51PHKG10.76928386
52PDK10.75236950
53SGK30.74801127
54PLK20.74230474
55STK240.73789373
56STK110.73054794
57SGK20.72659799
58SIK20.72078447
59PAK30.71625709
60PRPF4B0.71415798
61CAMK2A0.71408914
62MAP3K30.70636428
63MAP3K70.69653532
64ERBB20.67066311
65PRKCI0.65647503
66ICK0.65426605
67CAMKK20.64531359
68MAP3K10.64050166
69DYRK1A0.62783887
70MAPK120.62342138
71PRKCG0.59868828
72ALK0.59484111
73MAP3K110.58428453
74PNCK0.58246583
75EPHB10.58201458
76MAPK130.57226417
77MAPK100.55759547
78RET0.51367678
79PINK10.50788375
80ROCK20.50066782
81FER0.47053295
82CDK150.45622772
83MET0.44647603
84MAP2K40.43950739
85ROCK10.43531529
86FGFR30.43177732
87FYN0.43076707
88PRKCZ0.42625518
89MAP2K60.42405352
90CDK180.42060316
91PTK20.41041517
92RPS6KA30.41010488
93CASK0.40920384
94PRKG20.39752303
95PRKCA0.38954490
96CDC42BPA0.38854781
97CDK11A0.37871042
98TRPM70.37760860
99LRRK20.37103477
100TNK20.36346521

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.27144497
2Nicotine addiction_Homo sapiens_hsa050332.95109513
3Histidine metabolism_Homo sapiens_hsa003402.70581757
4Phenylalanine metabolism_Homo sapiens_hsa003602.64001442
5Amphetamine addiction_Homo sapiens_hsa050312.38141693
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.31355516
7Long-term potentiation_Homo sapiens_hsa047202.24393022
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13102508
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12952690
10Insulin secretion_Homo sapiens_hsa049112.08063780
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06427268
12Circadian entrainment_Homo sapiens_hsa047131.93998848
13Salivary secretion_Homo sapiens_hsa049701.93484696
14Glutamatergic synapse_Homo sapiens_hsa047241.80060720
15Gastric acid secretion_Homo sapiens_hsa049711.76730220
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70804031
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68996720
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66895340
19Cocaine addiction_Homo sapiens_hsa050301.65915744
20GABAergic synapse_Homo sapiens_hsa047271.64734861
21Tyrosine metabolism_Homo sapiens_hsa003501.61778186
22Chemical carcinogenesis_Homo sapiens_hsa052041.60780410
23beta-Alanine metabolism_Homo sapiens_hsa004101.58686827
24Morphine addiction_Homo sapiens_hsa050321.53295804
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52838626
26Dopaminergic synapse_Homo sapiens_hsa047281.51921834
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50253053
28cAMP signaling pathway_Homo sapiens_hsa040241.28843296
29Oxytocin signaling pathway_Homo sapiens_hsa049211.26672633
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26410638
31Calcium signaling pathway_Homo sapiens_hsa040201.26187265
32Collecting duct acid secretion_Homo sapiens_hsa049661.22236558
33Cholinergic synapse_Homo sapiens_hsa047251.19286120
34Renin secretion_Homo sapiens_hsa049241.19049834
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18410577
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17312074
37Taste transduction_Homo sapiens_hsa047421.13541281
38GnRH signaling pathway_Homo sapiens_hsa049121.12126034
39Pancreatic secretion_Homo sapiens_hsa049721.12031091
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03112208
41Tight junction_Homo sapiens_hsa045300.98476444
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95587109
43Vitamin B6 metabolism_Homo sapiens_hsa007500.94566147
44Estrogen signaling pathway_Homo sapiens_hsa049150.93794866
45Serotonergic synapse_Homo sapiens_hsa047260.91043891
46Vibrio cholerae infection_Homo sapiens_hsa051100.88816227
47Circadian rhythm_Homo sapiens_hsa047100.88245640
48Bile secretion_Homo sapiens_hsa049760.88193926
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86835306
50Olfactory transduction_Homo sapiens_hsa047400.86801109
51Melanogenesis_Homo sapiens_hsa049160.86250584
52Choline metabolism in cancer_Homo sapiens_hsa052310.80583343
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78526826
54Glioma_Homo sapiens_hsa052140.77446331
55Sphingolipid metabolism_Homo sapiens_hsa006000.77388752
56Thyroid hormone synthesis_Homo sapiens_hsa049180.74806008
57Type II diabetes mellitus_Homo sapiens_hsa049300.73542892
58Long-term depression_Homo sapiens_hsa047300.73048585
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.71440149
60Gap junction_Homo sapiens_hsa045400.69252183
61ABC transporters_Homo sapiens_hsa020100.68024686
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.65312955
63ErbB signaling pathway_Homo sapiens_hsa040120.64886141
64Inositol phosphate metabolism_Homo sapiens_hsa005620.64822145
65Endocytosis_Homo sapiens_hsa041440.64001506
66Glutathione metabolism_Homo sapiens_hsa004800.61565303
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61356663
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60680691
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.56258735
70Axon guidance_Homo sapiens_hsa043600.56193177
71VEGF signaling pathway_Homo sapiens_hsa043700.54728343
72Mineral absorption_Homo sapiens_hsa049780.52298011
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.51954762
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.50772128
75Retinol metabolism_Homo sapiens_hsa008300.48697228
76Huntingtons disease_Homo sapiens_hsa050160.48550241
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48464753
78Rap1 signaling pathway_Homo sapiens_hsa040150.47920211
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47853817
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46980733
81mTOR signaling pathway_Homo sapiens_hsa041500.46705021
82Dilated cardiomyopathy_Homo sapiens_hsa054140.46426312
83Prion diseases_Homo sapiens_hsa050200.46417805
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45486845
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.44035371
86Cardiac muscle contraction_Homo sapiens_hsa042600.43762222
87Glucagon signaling pathway_Homo sapiens_hsa049220.42981533
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42790152
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42248225
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41905273
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40674558
92Arginine and proline metabolism_Homo sapiens_hsa003300.39516049
93Arginine biosynthesis_Homo sapiens_hsa002200.39170091
94Ras signaling pathway_Homo sapiens_hsa040140.37908968
95Phototransduction_Homo sapiens_hsa047440.35594006
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35238339
97Oocyte meiosis_Homo sapiens_hsa041140.35201487
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34865958
99Amoebiasis_Homo sapiens_hsa051460.34535239
100MAPK signaling pathway_Homo sapiens_hsa040100.33676248

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