ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.77388447
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.89090652
3	indole-containing compound catabolic process (GO:0042436)	3.86435639
4	indolalkylamine catabolic process (GO:0046218)	3.86435639
5	tryptophan catabolic process (GO:0006569)	3.86435639
6	DNA deamination (GO:0045006)	3.83588050
7	indolalkylamine metabolic process (GO:0006586)	3.82358248
8	epithelial cilium movement (GO:0003351)	3.71123302
9	fucose catabolic process (GO:0019317)	3.63550486
10	L-fucose metabolic process (GO:0042354)	3.63550486
11	L-fucose catabolic process (GO:0042355)	3.63550486
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.57882704
13	kynurenine metabolic process (GO:0070189)	3.52805036
14	cellular ketone body metabolic process (GO:0046950)	3.42730073
15	platelet dense granule organization (GO:0060155)	3.40542878
16	response to pheromone (GO:0019236)	3.39748595
17	protein polyglutamylation (GO:0018095)	3.39434633
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.33435201
19	detection of light stimulus involved in visual perception (GO:0050908)	3.33435201
20	cilium or flagellum-dependent cell motility (GO:0001539)	3.31352313
21	tryptophan metabolic process (GO:0006568)	3.25311787
22	cilium movement (GO:0003341)	3.24825309
23	photoreceptor cell maintenance (GO:0045494)	3.23219011
24	piRNA metabolic process (GO:0034587)	3.20453244
25	nonmotile primary cilium assembly (GO:0035058)	3.19770575
26	axoneme assembly (GO:0035082)	3.18695996
27	retinal cone cell development (GO:0046549)	3.12063364
28	kidney morphogenesis (GO:0060993)	3.11933398
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.11648578
30	ketone body metabolic process (GO:1902224)	3.06076420
31	respiratory chain complex IV assembly (GO:0008535)	3.05290593
32	neural tube formation (GO:0001841)	3.03150588
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.99115118
34	regulation of translation, ncRNA-mediated (GO:0045974)	2.99115118
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.99115118
36	regulation of meiosis I (GO:0060631)	2.98614980
37	multicellular organism reproduction (GO:0032504)	2.94545949
38	regulation of cilium movement (GO:0003352)	2.94242218
39	centriole replication (GO:0007099)	2.92325901
40	protein complex biogenesis (GO:0070271)	2.88077214
41	regulation of hexokinase activity (GO:1903299)	2.86515504
42	regulation of glucokinase activity (GO:0033131)	2.86515504
43	indole-containing compound metabolic process (GO:0042430)	2.85260775
44	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.85102378
45	negative regulation of telomere maintenance (GO:0032205)	2.82579740
46	regulation of posttranscriptional gene silencing (GO:0060147)	2.81774568
47	regulation of gene silencing by miRNA (GO:0060964)	2.81774568
48	regulation of gene silencing by RNA (GO:0060966)	2.81774568
49	cilium morphogenesis (GO:0060271)	2.81675422
50	cilium organization (GO:0044782)	2.81361153
51	behavioral response to ethanol (GO:0048149)	2.76559136
52	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75777416
53	reciprocal meiotic recombination (GO:0007131)	2.75352927
54	reciprocal DNA recombination (GO:0035825)	2.75352927
55	replication fork processing (GO:0031297)	2.75243522
56	DNA methylation involved in gamete generation (GO:0043046)	2.74628706
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.73573662
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.73573662
59	NADH dehydrogenase complex assembly (GO:0010257)	2.73573662
60	protein K11-linked deubiquitination (GO:0035871)	2.72769558
61	cilium assembly (GO:0042384)	2.72061451
62	cellular biogenic amine catabolic process (GO:0042402)	2.71444994
63	amine catabolic process (GO:0009310)	2.71444994
64	regulation of hippo signaling (GO:0035330)	2.69571590
65	sulfation (GO:0051923)	2.69320513
66	signal peptide processing (GO:0006465)	2.68307052
67	sperm motility (GO:0030317)	2.67744562
68	male meiosis I (GO:0007141)	2.66975051
69	reflex (GO:0060004)	2.65987987
70	cytochrome complex assembly (GO:0017004)	2.65979519
71	protein localization to cilium (GO:0061512)	2.61774394
72	protein-cofactor linkage (GO:0018065)	2.61012756
73	recombinational repair (GO:0000725)	2.60835816
74	double-strand break repair via homologous recombination (GO:0000724)	2.59937625
75	photoreceptor cell development (GO:0042461)	2.59826287
76	neuronal action potential (GO:0019228)	2.58506723
77	adaptation of signaling pathway (GO:0023058)	2.58462623
78	somite rostral/caudal axis specification (GO:0032525)	2.58374206
79	primary amino compound metabolic process (GO:1901160)	2.58078739
80	mitochondrial respiratory chain complex assembly (GO:0033108)	2.57805532
81	mannosylation (GO:0097502)	2.55730435
82	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.55586649
83	DNA double-strand break processing (GO:0000729)	2.54693815
84	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.53986762
85	regulation of mesoderm development (GO:2000380)	2.53797822
86	negative regulation of mast cell activation (GO:0033004)	2.52167014
87	serotonin metabolic process (GO:0042428)	2.51157623
88	somite development (GO:0061053)	2.49432847
89	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49330375
90	cornea development in camera-type eye (GO:0061303)	2.49318769
91	rhodopsin mediated signaling pathway (GO:0016056)	2.47053959
92	spinal cord motor neuron differentiation (GO:0021522)	2.46241661
93	NAD biosynthetic process (GO:0009435)	2.45285561
94	synapsis (GO:0007129)	2.44230288
95	male meiosis (GO:0007140)	2.43686616
96	protein prenylation (GO:0018342)	2.42452260
97	prenylation (GO:0097354)	2.42452260
98	gamma-aminobutyric acid transport (GO:0015812)	2.42014425
99	establishment of protein localization to Golgi (GO:0072600)	2.40370170
100	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.39897743

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68001497
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.18285757
3	VDR_22108803_ChIP-Seq_LS180_Human	3.09438954
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.05019690
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.74343588
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43076544
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39501716
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36983383
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36772817
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32007191
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.26475154
12	P300_19829295_ChIP-Seq_ESCs_Human	2.18228061
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17218408
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15716989
15	EWS_26573619_Chip-Seq_HEK293_Human	2.11625090
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11419513
17	FUS_26573619_Chip-Seq_HEK293_Human	2.03172631
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.92201951
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.91895998
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85349249
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80030520
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76897766
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76765400
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73210743
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.72192447
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72088763
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70431888
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68702850
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.67604916
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67604916
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64266639
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59599699
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59185030
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.58772182
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.55323877
36	STAT3_23295773_ChIP-Seq_U87_Human	1.54494408
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52223889
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.51660696
39	AR_25329375_ChIP-Seq_VCAP_Human	1.51367840
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49131861
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.48965129
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48965129
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47868112
44	TCF4_23295773_ChIP-Seq_U87_Human	1.44327036
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42261771
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41913049
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41461275
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41269492
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40858985
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40715529
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38856241
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38759111
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38759111
54	* TCF4_22108803_ChIP-Seq_LS180_Human	1.36634674
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34672296
56	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33099024
57	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32631800
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32509696
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31049518
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30857635
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29902949
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29902949
63	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29507781
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.28409365
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26401597
66	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25273089
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25124554
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.24977069
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24958595
70	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23167225
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23081245
72	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.22579092
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21433209
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18812192
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17978542
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.17449974
77	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16533395
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15191500
79	AR_20517297_ChIP-Seq_VCAP_Human	1.14284249
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14187050
81	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13216777
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12176984
83	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.11324718
84	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08456114
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08369837
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08140571
87	NCOR_22424771_ChIP-Seq_293T_Human	1.07915991
88	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04900480
89	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04224467
90	CDX2_22108803_ChIP-Seq_LS180_Human	1.04216091
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04213476
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02847540
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02341678
94	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.02000186
95	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00432281
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99341507
97	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98821328
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98370580
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95330125
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.92972019

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.36721682
2	MP0003195_calcinosis	3.16960252
3	MP0006292_abnormal_olfactory_placode	3.10570612
4	MP0003787_abnormal_imprinting	2.66096134
5	MP0003136_yellow_coat_color	2.46490694
6	MP0005551_abnormal_eye_electrophysiolog	2.38001722
7	MP0002102_abnormal_ear_morphology	2.28997670
8	MP0002837_dystrophic_cardiac_calcinosis	2.07441089
9	MP0001968_abnormal_touch/_nociception	1.98420025
10	MP0006072_abnormal_retinal_apoptosis	1.93618552
11	MP0009046_muscle_twitch	1.93589396
12	MP0005646_abnormal_pituitary_gland	1.86340550
13	MP0009745_abnormal_behavioral_response	1.84391736
14	MP0000569_abnormal_digit_pigmentation	1.84244106
15	MP0003880_abnormal_central_pattern	1.82879872
16	MP0001501_abnormal_sleep_pattern	1.81044488
17	MP0004142_abnormal_muscle_tone	1.80983147
18	MP0002638_abnormal_pupillary_reflex	1.77383977
19	MP0002736_abnormal_nociception_after	1.77308992
20	MP0001485_abnormal_pinna_reflex	1.77189911
21	MP0005253_abnormal_eye_physiology	1.76116410
22	MP0001986_abnormal_taste_sensitivity	1.75277251
23	MP0006276_abnormal_autonomic_nervous	1.70657283
24	MP0001984_abnormal_olfaction	1.70171051
25	MP0003718_maternal_effect	1.67195755
26	MP0004147_increased_porphyrin_level	1.63811274
27	MP0003646_muscle_fatigue	1.63232914
28	MP0004885_abnormal_endolymph	1.59626129
29	MP0000631_abnormal_neuroendocrine_gland	1.59020087
30	MP0005645_abnormal_hypothalamus_physiol	1.58872933
31	MP0003121_genomic_imprinting	1.56832702
32	MP0008872_abnormal_physiological_respon	1.56353295
33	MP0002938_white_spotting	1.56117199
34	MP0002272_abnormal_nervous_system	1.55034576
35	MP0002876_abnormal_thyroid_physiology	1.52115799
36	MP0000427_abnormal_hair_cycle	1.51093202
37	MP0004133_heterotaxia	1.51055787
38	MP0002653_abnormal_ependyma_morphology	1.50063829
39	MP0001529_abnormal_vocalization	1.47647819
40	MP0001486_abnormal_startle_reflex	1.42182085
41	MP0005084_abnormal_gallbladder_morpholo	1.36556609
42	MP0002735_abnormal_chemical_nociception	1.36291638
43	MP0004043_abnormal_pH_regulation	1.35273970
44	MP0005410_abnormal_fertilization	1.34354252
45	MP0008789_abnormal_olfactory_epithelium	1.33193507
46	MP0003890_abnormal_embryonic-extraembry	1.31311460
47	MP0003011_delayed_dark_adaptation	1.31067043
48	MP0010386_abnormal_urinary_bladder	1.30403887
49	MP0000372_irregular_coat_pigmentation	1.29976130
50	MP0008995_early_reproductive_senescence	1.27113796
51	MP0002572_abnormal_emotion/affect_behav	1.22600271
52	MP0002557_abnormal_social/conspecific_i	1.21267880
53	MP0005174_abnormal_tail_pigmentation	1.21218973
54	MP0008058_abnormal_DNA_repair	1.18823279
55	MP0002160_abnormal_reproductive_system	1.18626604
56	MP0004742_abnormal_vestibular_system	1.16269384
57	MP0005389_reproductive_system_phenotype	1.15630154
58	MP0003122_maternal_imprinting	1.13538559
59	MP0008875_abnormal_xenobiotic_pharmacok	1.13436985
60	MP0002064_seizures	1.12650006
61	MP0001970_abnormal_pain_threshold	1.12403965
62	MP0002277_abnormal_respiratory_mucosa	1.12237920
63	MP0005377_hearing/vestibular/ear_phenot	1.12213196
64	MP0003878_abnormal_ear_physiology	1.12213196
65	MP0002928_abnormal_bile_duct	1.11761296
66	MP0003283_abnormal_digestive_organ	1.11539022
67	MP0002138_abnormal_hepatobiliary_system	1.11297797
68	MP0003698_abnormal_male_reproductive	1.09910623
69	MP0001929_abnormal_gametogenesis	1.09591844
70	MP0001905_abnormal_dopamine_level	1.09434771
71	MP0002234_abnormal_pharynx_morphology	1.05418977
72	MP0004924_abnormal_behavior	1.04970075
73	MP0005386_behavior/neurological_phenoty	1.04970075
74	MP0002733_abnormal_thermal_nociception	1.02235823
75	MP0005499_abnormal_olfactory_system	0.99624304
76	MP0005394_taste/olfaction_phenotype	0.99624304
77	MP0002751_abnormal_autonomic_nervous	0.99536888
78	MP0005423_abnormal_somatic_nervous	0.99052250
79	MP0002067_abnormal_sensory_capabilities	0.97811631
80	MP0005195_abnormal_posterior_eye	0.97187497
81	MP0005075_abnormal_melanosome_morpholog	0.95219319
82	MP0002210_abnormal_sex_determination	0.94831961
83	MP0003119_abnormal_digestive_system	0.92739562
84	MP0002163_abnormal_gland_morphology	0.91872739
85	MP0005167_abnormal_blood-brain_barrier	0.91284199
86	MP0001919_abnormal_reproductive_system	0.91232515
87	MP0003635_abnormal_synaptic_transmissio	0.90151038
88	MP0001293_anophthalmia	0.89746886
89	MP0002752_abnormal_somatic_nervous	0.88363712
90	MP0000653_abnormal_sex_gland	0.87250013
91	MP0002909_abnormal_adrenal_gland	0.86518140
92	MP0002254_reproductive_system_inflammat	0.86082765
93	MP0002095_abnormal_skin_pigmentation	0.86009684
94	MP0008057_abnormal_DNA_replication	0.85911657
95	MP0000026_abnormal_inner_ear	0.85872326
96	MP0002734_abnormal_mechanical_nocicepti	0.84030485
97	MP0005085_abnormal_gallbladder_physiolo	0.83969606
98	MP0002822_catalepsy	0.83785727
99	MP0001324_abnormal_eye_pigmentation	0.82539870
100	MP0002693_abnormal_pancreas_physiology	0.82491151

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.53964020
2	Pancreatic fibrosis (HP:0100732)	4.16936831
3	True hermaphroditism (HP:0010459)	4.03713019
4	Abnormality of midbrain morphology (HP:0002418)	3.77533902
5	Molar tooth sign on MRI (HP:0002419)	3.77533902
6	Congenital stationary night blindness (HP:0007642)	3.42524963
7	Nephronophthisis (HP:0000090)	3.41848498
8	Medial flaring of the eyebrow (HP:0010747)	3.31303403
9	Attenuation of retinal blood vessels (HP:0007843)	3.13618193
10	Abnormality of the renal medulla (HP:0100957)	3.01722232
11	Abnormality of the renal cortex (HP:0011035)	3.00498432
12	Abolished electroretinogram (ERG) (HP:0000550)	2.88571529
13	Cystic liver disease (HP:0006706)	2.82456722
14	Type II lissencephaly (HP:0007260)	2.78827651
15	Chronic hepatic failure (HP:0100626)	2.75066101
16	Absent/shortened dynein arms (HP:0200106)	2.72814269
17	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.72814269
18	Gait imbalance (HP:0002141)	2.62618941
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.61587434
20	Congenital primary aphakia (HP:0007707)	2.59608755
21	Gaze-evoked nystagmus (HP:0000640)	2.58905167
22	Progressive cerebellar ataxia (HP:0002073)	2.58443619
23	Pendular nystagmus (HP:0012043)	2.54400911
24	Sclerocornea (HP:0000647)	2.48803614
25	Abnormal ciliary motility (HP:0012262)	2.46469186
26	Hyperventilation (HP:0002883)	2.46131234
27	Abnormal drinking behavior (HP:0030082)	2.45929034
28	Polydipsia (HP:0001959)	2.45929034
29	Tubular atrophy (HP:0000092)	2.44838392
30	Hypothermia (HP:0002045)	2.42292564
31	Bony spicule pigmentary retinopathy (HP:0007737)	2.38299062
32	Nephrogenic diabetes insipidus (HP:0009806)	2.38257851
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.35591759
34	Decreased central vision (HP:0007663)	2.34596417
35	Congenital, generalized hypertrichosis (HP:0004540)	2.33925090
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.31954320
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.31954320
38	Genetic anticipation (HP:0003743)	2.29472016
39	Progressive inability to walk (HP:0002505)	2.26577730
40	Large for gestational age (HP:0001520)	2.25338572
41	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.24781936
42	Abnormality of alanine metabolism (HP:0010916)	2.21501299
43	Hyperalaninemia (HP:0003348)	2.21501299
44	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.21501299
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20539463
46	Genital tract atresia (HP:0001827)	2.19991706
47	Anencephaly (HP:0002323)	2.19164538
48	Male pseudohermaphroditism (HP:0000037)	2.18088306
49	Abnormality of the labia minora (HP:0012880)	2.17672661
50	Inability to walk (HP:0002540)	2.17612947
51	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.15072718
52	Hypoplasia of the fovea (HP:0007750)	2.15072718
53	Congenital hepatic fibrosis (HP:0002612)	2.15067257
54	Congenital sensorineural hearing impairment (HP:0008527)	2.14479872
55	Methylmalonic acidemia (HP:0002912)	2.13703910
56	Renal cortical cysts (HP:0000803)	2.13095580
57	Optic nerve hypoplasia (HP:0000609)	2.11176002
58	Vaginal atresia (HP:0000148)	2.10506382
59	Abnormal respiratory motile cilium physiology (HP:0012261)	2.07844112
60	Cerebellar dysplasia (HP:0007033)	2.06199516
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.05637256
62	Abnormal biliary tract physiology (HP:0012439)	2.05514661
63	Bile duct proliferation (HP:0001408)	2.05514661
64	Intestinal atresia (HP:0011100)	2.03370053
65	Abnormality of the pons (HP:0007361)	2.02378940
66	Furrowed tongue (HP:0000221)	2.02226529
67	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99504718
68	Polyuria (HP:0000103)	1.98498697
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97053734
70	Lissencephaly (HP:0001339)	1.95701962
71	Hypoplasia of the pons (HP:0012110)	1.95612420
72	Increased corneal curvature (HP:0100692)	1.95566910
73	Keratoconus (HP:0000563)	1.95566910
74	Febrile seizures (HP:0002373)	1.94504907
75	Increased CSF lactate (HP:0002490)	1.94104122
76	Poor coordination (HP:0002370)	1.93606578
77	Broad-based gait (HP:0002136)	1.89741258
78	Methylmalonic aciduria (HP:0012120)	1.89573626
79	Mitochondrial inheritance (HP:0001427)	1.88598068
80	Postaxial foot polydactyly (HP:0001830)	1.88173714
81	Abnormality of macular pigmentation (HP:0008002)	1.88092871
82	Abnormality of the fovea (HP:0000493)	1.85362621
83	Constricted visual fields (HP:0001133)	1.84683794
84	Supernumerary spleens (HP:0009799)	1.83508175
85	Acute necrotizing encephalopathy (HP:0006965)	1.82563720
86	Retinitis pigmentosa (HP:0000510)	1.81401463
87	Hemiparesis (HP:0001269)	1.80499376
88	Stomach cancer (HP:0012126)	1.78280905
89	3-Methylglutaconic aciduria (HP:0003535)	1.77299519
90	Decreased circulating renin level (HP:0003351)	1.76327459
91	Postaxial hand polydactyly (HP:0001162)	1.75745308
92	Abnormality of the ileum (HP:0001549)	1.74526093
93	Optic disc pallor (HP:0000543)	1.73376587
94	Septo-optic dysplasia (HP:0100842)	1.73077506
95	Preaxial hand polydactyly (HP:0001177)	1.72096001
96	Ketoacidosis (HP:0001993)	1.71619807
97	Bilateral microphthalmos (HP:0007633)	1.70171952
98	Ketosis (HP:0001946)	1.69206843
99	Retinal dysplasia (HP:0007973)	1.68188238
100	Protruding tongue (HP:0010808)	1.67969984

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.82346346
2	BMPR1B	3.19070421
3	ZAK	2.97775000
4	WNK3	2.77048143
5	ADRBK2	2.75630431
6	ACVR1B	2.63210917
7	INSRR	2.51833977
8	GRK1	2.49140516
9	TAOK3	2.13774160
10	PINK1	2.11695630
11	NUAK1	2.09784078
12	MAP4K2	2.08836695
13	TNIK	1.90258452
14	TRIM28	1.81091293
15	TLK1	1.75323033
16	MAPK13	1.72771622
17	CASK	1.63528366
18	MAP3K4	1.55490232
19	OXSR1	1.47858299
20	WNK4	1.44748460
21	MKNK2	1.39784323
22	TXK	1.36625603
23	MST4	1.26042226
24	TIE1	1.18014832
25	BRSK2	1.16477081
26	STK39	1.11737328
27	DAPK2	1.07601933
28	VRK1	1.05062575
29	DYRK2	1.04795587
30	NTRK3	1.04024147
31	STK38L	1.01743316
32	PNCK	1.00665236
33	TGFBR1	0.97526333
34	ADRBK1	0.96719482
35	PLK2	0.96509222
36	PRKCE	0.90764776
37	PLK3	0.90591116
38	PRKCG	0.90131701
39	PLK4	0.87343278
40	PAK3	0.86882310
41	MAP2K7	0.85612949
42	TEC	0.78254533
43	FGFR2	0.78144798
44	PTK2B	0.75977514
45	CSNK1G1	0.75433769
46	EIF2AK3	0.75124350
47	MARK1	0.73495097
48	IRAK1	0.71990283
49	NEK2	0.70876934
50	BCKDK	0.69741068
51	CSNK1G2	0.69506669
52	MKNK1	0.67254435
53	VRK2	0.67029677
54	STK3	0.65508643
55	WEE1	0.63718059
56	MAPK15	0.63591540
57	NLK	0.62713688
58	PASK	0.62015047
59	CSNK1G3	0.59149977
60	MARK3	0.58747259
61	PHKG1	0.58136615
62	PHKG2	0.58136615
63	CHUK	0.56266870
64	TAF1	0.56255196
65	NTRK2	0.56010607
66	IKBKB	0.53407068
67	CDC7	0.52421424
68	TNK2	0.52295551
69	ERBB3	0.51534069
70	DYRK3	0.51428304
71	PLK1	0.51259522
72	EPHA4	0.50510787
73	CSNK1A1L	0.48493520
74	PKN1	0.48332540
75	MUSK	0.47207816
76	STK16	0.46689155
77	CDK19	0.46521495
78	KIT	0.45752696
79	STK11	0.45594036
80	CDK3	0.44659432
81	PRKCQ	0.44512688
82	PRKCI	0.43386218
83	ITK	0.43201516
84	CAMK2A	0.43128597
85	FER	0.41275687
86	BCR	0.41187173
87	PRKACA	0.41162283
88	SIK2	0.40578887
89	CSNK1A1	0.39208483
90	OBSCN	0.38874867
91	MAPKAPK3	0.38513081
92	PRKG1	0.38197920
93	FLT3	0.37773973
94	NME1	0.37020951
95	PIK3CA	0.35959470
96	PRKAA2	0.35777202
97	RPS6KA5	0.34674147
98	CSNK1D	0.34240643
99	ATR	0.32819483
100	AKT3	0.32121176

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.80933791
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.60244743
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.55753246
4	Butanoate metabolism_Homo sapiens_hsa00650	2.43644055
5	Homologous recombination_Homo sapiens_hsa03440	2.43061806
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.27459438
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.18971301
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.18684518
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.13393528
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.12574724
11	Nicotine addiction_Homo sapiens_hsa05033	2.04793072
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.94874230
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93808409
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.92177792
15	Protein export_Homo sapiens_hsa03060	1.91465320
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.89200929
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.87792715
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86326559
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.82454305
20	RNA polymerase_Homo sapiens_hsa03020	1.82444274
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79844518
22	Basal transcription factors_Homo sapiens_hsa03022	1.74168968
23	Taste transduction_Homo sapiens_hsa04742	1.69441022
24	Parkinsons disease_Homo sapiens_hsa05012	1.65183662
25	Olfactory transduction_Homo sapiens_hsa04740	1.62342494
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.55887145
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53942427
28	Propanoate metabolism_Homo sapiens_hsa00640	1.53055835
29	ABC transporters_Homo sapiens_hsa02010	1.39405971
30	Caffeine metabolism_Homo sapiens_hsa00232	1.37364080
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.37042540
32	RNA degradation_Homo sapiens_hsa03018	1.32889861
33	Morphine addiction_Homo sapiens_hsa05032	1.32793808
34	Huntingtons disease_Homo sapiens_hsa05016	1.26905999
35	Peroxisome_Homo sapiens_hsa04146	1.18326329
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.17197589
37	Insulin secretion_Homo sapiens_hsa04911	1.16281520
38	Regulation of autophagy_Homo sapiens_hsa04140	1.13715123
39	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09267357
40	Serotonergic synapse_Homo sapiens_hsa04726	1.07265071
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05455532
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04934047
43	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04802688
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03957417
45	Retinol metabolism_Homo sapiens_hsa00830	1.02682669
46	GABAergic synapse_Homo sapiens_hsa04727	1.01424897
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97297545
48	Alzheimers disease_Homo sapiens_hsa05010	0.97070070
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95229323
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.94404621
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93143031
52	Circadian entrainment_Homo sapiens_hsa04713	0.92236236
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.91586117
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.90912158
55	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88397551
56	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85914641
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.85695232
58	One carbon pool by folate_Homo sapiens_hsa00670	0.83130916
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82214902
60	Purine metabolism_Homo sapiens_hsa00230	0.79402354
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.77641390
62	Proteasome_Homo sapiens_hsa03050	0.75512451
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71843663
64	Histidine metabolism_Homo sapiens_hsa00340	0.71716025
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70501975
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.70262618
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68160421
68	Circadian rhythm_Homo sapiens_hsa04710	0.66776937
69	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65400525
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63202614
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61745278
72	Metabolic pathways_Homo sapiens_hsa01100	0.61047082
73	Mismatch repair_Homo sapiens_hsa03430	0.60526388
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.58204983
75	Salivary secretion_Homo sapiens_hsa04970	0.57056981
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.56893526
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55813720
78	Fatty acid degradation_Homo sapiens_hsa00071	0.55616459
79	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55073427
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53523114
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51503265
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.51143081
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51005214
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50413491
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48667690
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.43879598
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.42595964
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42272729
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41429580
90	Cocaine addiction_Homo sapiens_hsa05030	0.40054794
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38913632
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37012670
93	Mineral absorption_Homo sapiens_hsa04978	0.36992754
94	Asthma_Homo sapiens_hsa05310	0.36894853
95	Long-term depression_Homo sapiens_hsa04730	0.36761255
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.34119532
97	Cholinergic synapse_Homo sapiens_hsa04725	0.33953260
98	Primary immunodeficiency_Homo sapiens_hsa05340	0.32472880
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.32452219
100	RNA transport_Homo sapiens_hsa03013	0.32049325

KIAA1257

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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