KIAA1429

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein heterodimerization activity (GO:0043497)7.76114676
2positive regulation of protein homodimerization activity (GO:0090073)7.47542267
3nuclear pore complex assembly (GO:0051292)7.16850754
4nuclear pore organization (GO:0006999)6.23492479
5regulation of RNA export from nucleus (GO:0046831)5.72478784
6oocyte development (GO:0048599)5.53495465
7cerebellar granule cell differentiation (GO:0021707)5.48278641
8positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.43154800
9neuron remodeling (GO:0016322)5.38510076
10snRNA transcription (GO:0009301)5.30032714
11pore complex assembly (GO:0046931)5.17264803
12negative regulation of cell cycle arrest (GO:0071157)5.11580203
13positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.07772887
14positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.07772887
15positive regulation of mitotic sister chromatid separation (GO:1901970)5.07772887
16interkinetic nuclear migration (GO:0022027)4.89645448
17substrate-dependent cell migration (GO:0006929)4.82995611
18mitotic sister chromatid cohesion (GO:0007064)4.51318226
19monoubiquitinated protein deubiquitination (GO:0035520)4.48917843
20regulation of nucleobase-containing compound transport (GO:0032239)4.45291704
21regulation of DNA endoreduplication (GO:0032875)4.42511521
22negative regulation of DNA repair (GO:0045738)4.14808354
23cytoplasmic mRNA processing body assembly (GO:0033962)4.12058470
24negative regulation of T cell differentiation in thymus (GO:0033085)4.02839536
25DNA synthesis involved in DNA repair (GO:0000731)3.95269726
26early endosome to late endosome transport (GO:0045022)3.83782751
27positive regulation of chromosome segregation (GO:0051984)3.67457113
28regulation of centriole replication (GO:0046599)3.57562750
29NLS-bearing protein import into nucleus (GO:0006607)3.55028465
30regulation of sister chromatid cohesion (GO:0007063)3.50106570
31double-strand break repair via nonhomologous end joining (GO:0006303)3.43689394
32non-recombinational repair (GO:0000726)3.43689394
33mitotic chromosome condensation (GO:0007076)3.40199320
34regulation of histone H3-K27 methylation (GO:0061085)3.36779203
35regulation of protein homodimerization activity (GO:0043496)3.30661452
36mature B cell differentiation (GO:0002335)3.29851455
37ephrin receptor signaling pathway (GO:0048013)3.23114286
38protein targeting to lysosome (GO:0006622)3.21662590
39establishment of protein localization to vacuole (GO:0072666)3.21662590
40protein targeting to vacuole (GO:0006623)3.21662590
41neuron maturation (GO:0042551)3.18536270
42COPII vesicle coating (GO:0048208)3.18311114
43sister chromatid cohesion (GO:0007062)3.14427507
44protein maturation by protein folding (GO:0022417)3.09024165
45DNA unwinding involved in DNA replication (GO:0006268)3.02730951
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01935084
47DNA duplex unwinding (GO:0032508)3.00670127
48negative regulation of keratinocyte proliferation (GO:0010839)2.99536694
49meiotic chromosome segregation (GO:0045132)2.97764324
50DNA geometric change (GO:0032392)2.96186780
51sister chromatid segregation (GO:0000819)2.94150620
52establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.90989636
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86580576
54response to UV-C (GO:0010225)2.82626582
55regulation of hippo signaling (GO:0035330)2.80064830
56regulation of translational fidelity (GO:0006450)2.78374255
57histone H2A ubiquitination (GO:0033522)2.76863949
58peptidyl-lysine trimethylation (GO:0018023)2.76772151
59positive regulation of p38MAPK cascade (GO:1900745)2.74534193
60regulation of centrosome duplication (GO:0010824)2.73676990
61mitotic nuclear envelope disassembly (GO:0007077)2.72097036
62postreplication repair (GO:0006301)2.70832938
63ER overload response (GO:0006983)2.69596426
64negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.67902303
65positive regulation of mitotic cell cycle phase transition (GO:1901992)2.67087329
66cell differentiation in hindbrain (GO:0021533)2.66912097
67mRNA cleavage (GO:0006379)2.65218632
68atrial cardiac muscle cell action potential (GO:0086014)2.63139650
69rRNA catabolic process (GO:0016075)2.62668319
70positive regulation of cell cycle phase transition (GO:1901989)2.60529223
71SMAD protein complex assembly (GO:0007183)2.59711636
72regulation of centrosome cycle (GO:0046605)2.59210098
73membrane disassembly (GO:0030397)2.57675346
74nuclear envelope disassembly (GO:0051081)2.57675346
75mitotic metaphase plate congression (GO:0007080)2.57530584
76mitotic sister chromatid segregation (GO:0000070)2.56291297
77regulation of cellular senescence (GO:2000772)2.56176015
78chaperone-mediated protein complex assembly (GO:0051131)2.54622810
79histone ubiquitination (GO:0016574)2.54592606
80regulation of protein polyubiquitination (GO:1902914)2.53824058
81protein localization to microtubule cytoskeleton (GO:0072698)2.53450810
82DNA replication initiation (GO:0006270)2.52929685
83negative regulation of cell aging (GO:0090344)2.52802596
84peptidyl-lysine methylation (GO:0018022)2.52363656
85gene silencing by RNA (GO:0031047)2.50296179
86positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.49900120
87DNA conformation change (GO:0071103)2.49754016
88regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.46955025
89microtubule anchoring (GO:0034453)2.45939317
90protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.45013284
91telomere maintenance via recombination (GO:0000722)2.44647888
92biotin metabolic process (GO:0006768)2.43703864
93histone deubiquitination (GO:0016578)2.43595536
94metaphase plate congression (GO:0051310)2.43461683
95nucleus organization (GO:0006997)2.42901506
96nucleus localization (GO:0051647)2.42757603
97establishment of tissue polarity (GO:0007164)2.42141080
98establishment of planar polarity (GO:0001736)2.42141080
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41798725
100regulation of translation, ncRNA-mediated (GO:0045974)2.41798725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.01646798
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.69072201
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.66256392
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.52708993
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50629856
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48185382
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.15107722
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.76760978
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64877351
10AR_21909140_ChIP-Seq_LNCAP_Human2.29725027
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.21442614
12EWS_26573619_Chip-Seq_HEK293_Human2.12014843
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.09000332
14IRF1_19129219_ChIP-ChIP_H3396_Human2.08291398
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04329799
16* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.04005265
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02386240
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.89875456
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88171600
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87103642
21PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82522719
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82120002
23TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.75287182
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72917937
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.68539947
26TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63766989
27PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62681955
28ER_23166858_ChIP-Seq_MCF-7_Human1.62666869
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59978520
30FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.54498808
31AHR_22903824_ChIP-Seq_MCF-7_Human1.52300618
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51440200
33AR_21572438_ChIP-Seq_LNCaP_Human1.50424362
34* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.50256202
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49123614
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.48804342
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48057851
38FUS_26573619_Chip-Seq_HEK293_Human1.46928757
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46868437
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46427910
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45688011
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44879908
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44270137
44ZNF274_21170338_ChIP-Seq_K562_Hela1.41349045
45BRD4_25478319_ChIP-Seq_HGPS_Human1.41013224
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40753209
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35352547
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.30369669
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.26683352
50* CHD1_26751641_Chip-Seq_LNCaP_Human1.21422968
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19936720
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17556873
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.16839273
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14256193
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.12022211
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.09216433
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08734463
58KDM5A_27292631_Chip-Seq_BREAST_Human1.07587445
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06195289
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05386032
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03732875
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03627498
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.03503680
64TFEB_21752829_ChIP-Seq_HELA_Human1.03213736
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02785248
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02785248
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02572540
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02496196
69TAF15_26573619_Chip-Seq_HEK293_Human1.02454976
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00099724
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99341531
72TCF4_23295773_ChIP-Seq_U87_Human0.99019000
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98174923
74STAT3_23295773_ChIP-Seq_U87_Human0.97804458
75GATA3_24758297_ChIP-Seq_MCF-7_Human0.97482763
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96652373
77* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95798002
78SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95026002
79SOX9_26525672_Chip-Seq_HEART_Mouse0.93584609
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92879616
81CIITA_25753668_ChIP-Seq_RAJI_Human0.91775755
82BCAT_22108803_ChIP-Seq_LS180_Human0.89345455
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88391353
84NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87776273
85REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87480367
86CDX2_22108803_ChIP-Seq_LS180_Human0.87163802
87GATA6_25053715_ChIP-Seq_YYC3_Human0.86624552
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86477735
89DCP1A_22483619_ChIP-Seq_HELA_Human0.85921430
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85415420
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84766338
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84726255
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84721434
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84564701
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.83752502
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83604629
97* GABP_17652178_ChIP-ChIP_JURKAT_Human0.82904716
98* FOXA1_25552417_ChIP-Seq_VCAP_Human0.82107351
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80732338
100CJUN_26792858_Chip-Seq_BT549_Human0.79493590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.85502982
2MP0004185_abnormal_adipocyte_glucose2.93443664
3MP0004957_abnormal_blastocyst_morpholog2.89840312
4MP0003705_abnormal_hypodermis_morpholog2.80947325
5MP0002009_preneoplasia2.72695991
6MP0009780_abnormal_chondrocyte_physiolo2.50666947
7MP0010352_gastrointestinal_tract_polyps2.49530513
8MP0000569_abnormal_digit_pigmentation2.33999299
9MP0003890_abnormal_embryonic-extraembry2.33343748
10MP0010094_abnormal_chromosome_stability2.18873767
11MP0003693_abnormal_embryo_hatching2.13189471
12MP0003385_abnormal_body_wall2.11932994
13MP0005076_abnormal_cell_differentiation1.98725513
14MP0003950_abnormal_plasma_membrane1.95113039
15MP0003077_abnormal_cell_cycle1.91285658
16MP0005647_abnormal_sex_gland1.86988851
17MP0000427_abnormal_hair_cycle1.86757577
18MP0002084_abnormal_developmental_patter1.77613471
19MP0003111_abnormal_nucleus_morphology1.74784964
20MP0010307_abnormal_tumor_latency1.74154007
21MP0000537_abnormal_urethra_morphology1.73985560
22MP0005409_darkened_coat_color1.73490389
23MP0002088_abnormal_embryonic_growth/wei1.70357415
24MP0001697_abnormal_embryo_size1.69575426
25MP0003984_embryonic_growth_retardation1.68963067
26MP0001672_abnormal_embryogenesis/_devel1.66180011
27MP0005380_embryogenesis_phenotype1.66180011
28MP0010234_abnormal_vibrissa_follicle1.62962093
29MP0009053_abnormal_anal_canal1.56692345
30MP0000350_abnormal_cell_proliferation1.51962978
31MP0010368_abnormal_lymphatic_system1.51845393
32MP0001730_embryonic_growth_arrest1.50057255
33MP0009697_abnormal_copulation1.50033022
34MP0010678_abnormal_skin_adnexa1.48275526
35MP0003937_abnormal_limbs/digits/tail_de1.48246122
36MP0001661_extended_life_span1.46793168
37MP0002086_abnormal_extraembryonic_tissu1.44297369
38MP0009703_decreased_birth_body1.39983709
39MP0000383_abnormal_hair_follicle1.38547594
40MP0002877_abnormal_melanocyte_morpholog1.35883764
41MP0003943_abnormal_hepatobiliary_system1.35590718
42MP0009672_abnormal_birth_weight1.34276320
43MP0008932_abnormal_embryonic_tissue1.33009238
44MP0003941_abnormal_skin_development1.32325711
45MP0002085_abnormal_embryonic_tissue1.31547665
46MP0004233_abnormal_muscle_weight1.28130281
47MP0008438_abnormal_cutaneous_collagen1.27950094
48MP0002166_altered_tumor_susceptibility1.26188463
49MP0002396_abnormal_hematopoietic_system1.26075877
50MP0000778_abnormal_nervous_system1.25816337
51MP0008058_abnormal_DNA_repair1.25758255
52MP0004197_abnormal_fetal_growth/weight/1.22160933
53MP0008007_abnormal_cellular_replicative1.21309761
54MP0002080_prenatal_lethality1.20410204
55MP0001286_abnormal_eye_development1.18940294
56MP0002092_abnormal_eye_morphology1.18837426
57MP0003935_abnormal_craniofacial_develop1.18786245
58MP0002697_abnormal_eye_size1.17306202
59MP0005187_abnormal_penis_morphology1.17298936
60MP0003861_abnormal_nervous_system1.15307688
61MP0002006_tumorigenesis1.08651193
62MP0003632_abnormal_nervous_system1.07278494
63MP0008877_abnormal_DNA_methylation1.06777190
64MP0002160_abnormal_reproductive_system1.06695950
65MP0004272_abnormal_basement_membrane1.06497944
66MP0008961_abnormal_basal_metabolism1.03134991
67MP0003221_abnormal_cardiomyocyte_apopto1.02545995
68MP0001293_anophthalmia1.02005912
69MP0004808_abnormal_hematopoietic_stem0.99487566
70MP0003755_abnormal_palate_morphology0.98138338
71MP0002210_abnormal_sex_determination0.97640877
72MP0000371_diluted_coat_color0.97176773
73MP0003787_abnormal_imprinting0.95366667
74MP0003936_abnormal_reproductive_system0.94905324
75MP0001879_abnormal_lymphatic_vessel0.93469345
76MP0004264_abnormal_extraembryonic_tissu0.93340749
77MP0003566_abnormal_cell_adhesion0.92560119
78MP0000358_abnormal_cell_content/0.91914401
79MP0002075_abnormal_coat/hair_pigmentati0.90054562
80MP0004381_abnormal_hair_follicle0.89605617
81MP0005367_renal/urinary_system_phenotyp0.88656675
82MP0000516_abnormal_urinary_system0.88656675
83MP0003091_abnormal_cell_migration0.88447581
84MP0002234_abnormal_pharynx_morphology0.87715529
85MP0005408_hypopigmentation0.87161034
86MP0003942_abnormal_urinary_system0.86540651
87MP0005220_abnormal_exocrine_pancreas0.85345132
88MP0001784_abnormal_fluid_regulation0.84590026
89MP0002184_abnormal_innervation0.84323805
90MP0003115_abnormal_respiratory_system0.83329072
91MP0000534_abnormal_ureter_morphology0.82842572
92MP0002925_abnormal_cardiovascular_devel0.82213272
93MP0000627_abnormal_mammary_gland0.80584351
94MP0005666_abnormal_adipose_tissue0.79865410
95MP0005423_abnormal_somatic_nervous0.79591910
96MP0002928_abnormal_bile_duct0.78366250
97MP0000432_abnormal_head_morphology0.78021256
98MP0000428_abnormal_craniofacial_morphol0.75406687
99MP0001186_pigmentation_phenotype0.72897111
100MP0004130_abnormal_muscle_cell0.72528821

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.67225423
2Abnormal hair whorl (HP:0010721)4.40261088
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.94303626
4Broad face (HP:0000283)3.70080546
5Volvulus (HP:0002580)3.60068337
6Sparse lateral eyebrow (HP:0005338)3.57892331
7Deep philtrum (HP:0002002)3.20378059
8Acute myeloid leukemia (HP:0004808)3.10304685
9Termporal pattern (HP:0011008)2.79230401
10Insidious onset (HP:0003587)2.79230401
11Dysmetric saccades (HP:0000641)2.73256903
12Heterotopia (HP:0002282)2.68808295
13Absent frontal sinuses (HP:0002688)2.62236305
14Ankyloglossia (HP:0010296)2.60026876
15Papillary thyroid carcinoma (HP:0002895)2.54537504
16Overlapping toe (HP:0001845)2.52161394
17Abnormality of chromosome stability (HP:0003220)2.50650559
18Menstrual irregularities (HP:0000858)2.46180869
19Abnormality of oral frenula (HP:0000190)2.46126678
20Fair hair (HP:0002286)2.45512840
21Sandal gap (HP:0001852)2.42638689
22Obsessive-compulsive behavior (HP:0000722)2.40322610
23Poor coordination (HP:0002370)2.39636540
24Acute lymphatic leukemia (HP:0006721)2.36989554
25Smooth philtrum (HP:0000319)2.35413635
26Relative macrocephaly (HP:0004482)2.33802251
27Low posterior hairline (HP:0002162)2.32300074
28Wide intermamillary distance (HP:0006610)2.32048721
29Hyperventilation (HP:0002883)2.24166605
30Protruding tongue (HP:0010808)2.23220408
31Hypopigmentation of the fundus (HP:0007894)2.18073270
32Nephroblastoma (Wilms tumor) (HP:0002667)2.16377506
33Short chin (HP:0000331)2.14726239
34Cystic hygroma (HP:0000476)2.06710760
35Hip dysplasia (HP:0001385)2.06593556
36Increased nuchal translucency (HP:0010880)2.03847487
37Embryonal renal neoplasm (HP:0011794)2.03235297
38Abnormality of the carotid arteries (HP:0005344)2.03155736
39Long toe (HP:0010511)2.01347043
40Osteomalacia (HP:0002749)2.00485907
41Macroorchidism (HP:0000053)1.98704758
42Aplasia/Hypoplasia of the uvula (HP:0010293)1.97655458
43Nephrogenic diabetes insipidus (HP:0009806)1.95585986
44Curly hair (HP:0002212)1.95207756
45Prominent nose (HP:0000448)1.93685420
46Ectopic kidney (HP:0000086)1.92567567
47Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90657733
48Increased number of teeth (HP:0011069)1.87434405
49Drooling (HP:0002307)1.87026903
50Tapered finger (HP:0001182)1.86849365
51Long eyelashes (HP:0000527)1.86161637
52Congenital primary aphakia (HP:0007707)1.85716363
53Arterial tortuosity (HP:0005116)1.85524299
54Microglossia (HP:0000171)1.85217215
55Synophrys (HP:0000664)1.83348100
56Abnormality of the proximal phalanges of the hand (HP:0009834)1.83078536
57Abnormality of the preputium (HP:0100587)1.80431168
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79985136
59Biliary tract neoplasm (HP:0100574)1.78923991
60Neoplasm of the oral cavity (HP:0100649)1.78320276
61Generalized hypopigmentation of hair (HP:0011358)1.76364088
62Open mouth (HP:0000194)1.75091087
63Hypoplastic labia majora (HP:0000059)1.74447056
64Insomnia (HP:0100785)1.72045958
65Pes planus (HP:0001763)1.70280684
66Cafe-au-lait spot (HP:0000957)1.70018505
67Myelodysplasia (HP:0002863)1.69848006
68Renovascular hypertension (HP:0100817)1.69722448
69Missing ribs (HP:0000921)1.69562382
70Hyperacusis (HP:0010780)1.68748840
71Neoplasm of the small intestine (HP:0100833)1.68442779
72Poor speech (HP:0002465)1.68402879
73Thyroid carcinoma (HP:0002890)1.68009682
74Facial hemangioma (HP:0000329)1.67116600
75Short foot (HP:0001773)1.65902421
76Gait imbalance (HP:0002141)1.65117149
77Excessive salivation (HP:0003781)1.64264591
78Short nail (HP:0001799)1.62944269
79Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.61544304
80Deviation of the thumb (HP:0009603)1.61274246
81Truncal obesity (HP:0001956)1.61133631
82Malignant gastrointestinal tract tumors (HP:0006749)1.61026295
83Gastrointestinal carcinoma (HP:0002672)1.61026295
84Flat cornea (HP:0007720)1.60871371
85Abnormality of the frontal sinuses (HP:0002687)1.59358370
86Fibular aplasia (HP:0002990)1.56900430
87Low anterior hairline (HP:0000294)1.56746579
88Coarse hair (HP:0002208)1.55770884
89Abnormality of the ischium (HP:0003174)1.55414427
90Abnormality of the labia majora (HP:0012881)1.55301324
91Arteriovenous malformation (HP:0100026)1.54229577
92Capillary hemangiomas (HP:0005306)1.53603018
93Narrow palate (HP:0000189)1.52762465
94Glioma (HP:0009733)1.52102610
95Sloping forehead (HP:0000340)1.51966828
96Medulloblastoma (HP:0002885)1.51892942
97Asymmetry of the thorax (HP:0001555)1.51723811
98Abnormality of the 2nd finger (HP:0004100)1.51583346
99Vascular tortuosity (HP:0004948)1.51336935
100Hypoplastic ischia (HP:0003175)1.51041889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.78035745
2EEF2K3.06494667
3SCYL22.96073846
4LATS12.57824853
5TYRO32.40592786
6FRK2.35075841
7RPS6KB22.29594838
8TSSK62.20700648
9MET2.17002913
10PNCK2.16075738
11BMPR1B2.14564943
12CAMK1G2.08863036
13BRD42.07312250
14CAMK1D1.91001411
15CDK121.89906346
16ICK1.65090951
17NEK91.63064894
18STK31.61574584
19TTK1.61430688
20MST1R1.58513741
21CDK81.54502996
22BRSK21.52660539
23WEE11.51759678
24TAF11.51602024
25EIF2AK31.47841439
26EPHB11.41148287
27ERBB31.39934292
28SIK11.36619673
29AKT31.31992480
30SRPK11.29450585
31NEK21.20157868
32TGFBR11.18259227
33TRPM71.17398200
34PDGFRB1.11299348
35CLK11.10591852
36CDK71.10375913
37SMG11.09396534
38KSR11.07809900
39WNK11.06374762
40EIF2AK11.05498237
41PDGFRA1.05287890
42MELK1.01140717
43NEK61.00805292
44TRIB30.98701831
45PKN20.95553925
46MAP3K20.92710641
47FER0.92689321
48STK38L0.92412524
49MTOR0.92000224
50RPS6KB10.88197341
51MAP3K140.87981417
52ATR0.87255524
53CHEK20.87205825
54PBK0.87176850
55CHEK10.86365689
56ATM0.86213381
57TRIM280.85670474
58MKNK20.82924172
59ZAK0.82195286
60PLK30.81417624
61CASK0.81057497
62WNK40.78532396
63MST40.76917302
64CDC70.76913250
65STK390.75690007
66PTK60.73104034
67EPHB20.72490124
68PTK20.71773761
69EPHA20.70518337
70SIK20.70260216
71PLK10.68257987
72AURKB0.66612389
73PLK40.66219275
74PAK20.64980705
75LATS20.63842448
76CDK10.63684575
77FES0.63088320
78YES10.62676570
79DMPK0.62298954
80FGFR10.60255331
81ERBB40.59239009
82CDK40.54661774
83STK380.53705458
84SIK30.53331151
85BUB10.52875400
86CDK20.52332347
87CSNK1E0.51613692
88NUAK10.50394426
89MAPK140.45808211
90MKNK10.45501961
91CDK90.44140914
92MAP3K100.44096431
93STK40.42896209
94MAP2K10.41138720
95FGR0.40382000
96EIF2AK20.40233934
97TEC0.39410533
98CDK60.38829034
99NLK0.38673585
100NEK10.38593692

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.22151518
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45803618
3RNA transport_Homo sapiens_hsa030132.44505260
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43615075
5Phenylalanine metabolism_Homo sapiens_hsa003602.31540112
6Cell cycle_Homo sapiens_hsa041102.20638986
7Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.08684810
8Lysine degradation_Homo sapiens_hsa003102.03830457
9Chronic myeloid leukemia_Homo sapiens_hsa052201.84062539
10MicroRNAs in cancer_Homo sapiens_hsa052061.82084294
11Selenocompound metabolism_Homo sapiens_hsa004501.80803064
12Basal transcription factors_Homo sapiens_hsa030221.78741100
13Axon guidance_Homo sapiens_hsa043601.78325483
14mRNA surveillance pathway_Homo sapiens_hsa030151.77692131
15One carbon pool by folate_Homo sapiens_hsa006701.70874956
16Adherens junction_Homo sapiens_hsa045201.69763952
17DNA replication_Homo sapiens_hsa030301.66497539
18Pancreatic cancer_Homo sapiens_hsa052121.65142170
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57408198
20Colorectal cancer_Homo sapiens_hsa052101.51995228
21Fanconi anemia pathway_Homo sapiens_hsa034601.51059998
22Thyroid cancer_Homo sapiens_hsa052161.48452703
23Non-small cell lung cancer_Homo sapiens_hsa052231.39318292
24Endometrial cancer_Homo sapiens_hsa052131.37280170
25Prostate cancer_Homo sapiens_hsa052151.36993151
26Renal cell carcinoma_Homo sapiens_hsa052111.33325699
27Nucleotide excision repair_Homo sapiens_hsa034201.31453401
28Hippo signaling pathway_Homo sapiens_hsa043901.31127329
29Small cell lung cancer_Homo sapiens_hsa052221.28992143
30Viral carcinogenesis_Homo sapiens_hsa052031.27618015
31N-Glycan biosynthesis_Homo sapiens_hsa005101.27031123
32FoxO signaling pathway_Homo sapiens_hsa040681.24776131
33mTOR signaling pathway_Homo sapiens_hsa041501.22274088
34Spliceosome_Homo sapiens_hsa030401.19514550
35Homologous recombination_Homo sapiens_hsa034401.18494825
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18233497
37Melanoma_Homo sapiens_hsa052181.17627953
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17203387
39TGF-beta signaling pathway_Homo sapiens_hsa043501.16654832
40ErbB signaling pathway_Homo sapiens_hsa040121.15478180
41Mismatch repair_Homo sapiens_hsa034301.14729118
42Dorso-ventral axis formation_Homo sapiens_hsa043201.14316973
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11226509
44Proteoglycans in cancer_Homo sapiens_hsa052051.09415733
45RNA degradation_Homo sapiens_hsa030181.08395237
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07679767
47VEGF signaling pathway_Homo sapiens_hsa043701.06650156
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03924054
49Prolactin signaling pathway_Homo sapiens_hsa049171.01885458
50Alcoholism_Homo sapiens_hsa050341.00850916
51Focal adhesion_Homo sapiens_hsa045100.96673104
52B cell receptor signaling pathway_Homo sapiens_hsa046620.95540343
53p53 signaling pathway_Homo sapiens_hsa041150.93558471
54Inositol phosphate metabolism_Homo sapiens_hsa005620.92467707
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84827839
56Systemic lupus erythematosus_Homo sapiens_hsa053220.83829043
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83454893
58Glioma_Homo sapiens_hsa052140.83237434
59T cell receptor signaling pathway_Homo sapiens_hsa046600.81999967
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81694531
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80071290
62Choline metabolism in cancer_Homo sapiens_hsa052310.78442763
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77975993
64Type II diabetes mellitus_Homo sapiens_hsa049300.77911987
65beta-Alanine metabolism_Homo sapiens_hsa004100.74431556
66Shigellosis_Homo sapiens_hsa051310.73600563
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73321669
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.72660592
69Pathways in cancer_Homo sapiens_hsa052000.72187834
70Oocyte meiosis_Homo sapiens_hsa041140.71206637
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70965039
72Acute myeloid leukemia_Homo sapiens_hsa052210.70936095
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69145472
74Wnt signaling pathway_Homo sapiens_hsa043100.68753226
75MAPK signaling pathway_Homo sapiens_hsa040100.67328311
76Hepatitis B_Homo sapiens_hsa051610.65150776
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64972948
78Estrogen signaling pathway_Homo sapiens_hsa049150.63544435
79HTLV-I infection_Homo sapiens_hsa051660.62926167
80Measles_Homo sapiens_hsa051620.62085728
81Insulin signaling pathway_Homo sapiens_hsa049100.61676620
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.61009831
83AMPK signaling pathway_Homo sapiens_hsa041520.60574737
84Bladder cancer_Homo sapiens_hsa052190.56801403
85ECM-receptor interaction_Homo sapiens_hsa045120.52973420
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52437071
87Rap1 signaling pathway_Homo sapiens_hsa040150.51991239
88Insulin resistance_Homo sapiens_hsa049310.50553934
89Tyrosine metabolism_Homo sapiens_hsa003500.50136039
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49414735
91Ras signaling pathway_Homo sapiens_hsa040140.49082224
92Tight junction_Homo sapiens_hsa045300.47955018
93Circadian rhythm_Homo sapiens_hsa047100.47779799
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47543988
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46841684
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46715343
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.43957976
98GnRH signaling pathway_Homo sapiens_hsa049120.43311434
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40744227
100Protein export_Homo sapiens_hsa030600.39023068

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