KIAA1456

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.30073159
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.04161730
3gamma-aminobutyric acid transport (GO:0015812)3.97994675
4presynaptic membrane assembly (GO:0097105)3.93612666
5postsynaptic membrane organization (GO:0001941)3.88369799
6dendritic spine morphogenesis (GO:0060997)3.80406421
7transmission of nerve impulse (GO:0019226)3.78442574
8behavioral response to nicotine (GO:0035095)3.77758504
9presynaptic membrane organization (GO:0097090)3.75660904
10vocalization behavior (GO:0071625)3.72267103
11G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67908192
12neuronal action potential propagation (GO:0019227)3.67242906
13ionotropic glutamate receptor signaling pathway (GO:0035235)3.64773966
14glutamate receptor signaling pathway (GO:0007215)3.57685244
15membrane depolarization during action potential (GO:0086010)3.54984924
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45787775
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.45178454
18proline transport (GO:0015824)3.44004523
19adrenergic receptor signaling pathway (GO:0071875)3.42518925
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.40472642
21synaptic transmission, glutamatergic (GO:0035249)3.38557905
22synaptic vesicle maturation (GO:0016188)3.35331501
23protein localization to synapse (GO:0035418)3.31307202
24auditory behavior (GO:0031223)3.31161916
25neuronal action potential (GO:0019228)3.25028522
26neuron cell-cell adhesion (GO:0007158)3.22663128
27serotonin metabolic process (GO:0042428)3.19634594
28neurotransmitter-gated ion channel clustering (GO:0072578)3.16954706
29neuron-neuron synaptic transmission (GO:0007270)3.13000731
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.12713625
31negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10764087
32primary amino compound metabolic process (GO:1901160)3.07702171
33pyrimidine nucleobase catabolic process (GO:0006208)3.07233721
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07029858
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98733261
36startle response (GO:0001964)2.95767480
37central nervous system projection neuron axonogenesis (GO:0021952)2.95347322
38reflex (GO:0060004)2.95071070
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93606523
40neurotransmitter secretion (GO:0007269)2.91283617
41negative regulation of dendrite development (GO:2000171)2.91040898
42central nervous system neuron axonogenesis (GO:0021955)2.84931570
43indolalkylamine metabolic process (GO:0006586)2.83665066
44glutamate secretion (GO:0014047)2.82652997
45indole-containing compound catabolic process (GO:0042436)2.82562197
46indolalkylamine catabolic process (GO:0046218)2.82562197
47tryptophan catabolic process (GO:0006569)2.82562197
48detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81609779
49kynurenine metabolic process (GO:0070189)2.81552806
50L-fucose catabolic process (GO:0042355)2.80194255
51fucose catabolic process (GO:0019317)2.80194255
52L-fucose metabolic process (GO:0042354)2.80194255
53response to pheromone (GO:0019236)2.77793491
54glycosphingolipid biosynthetic process (GO:0006688)2.77019829
55retinal cone cell development (GO:0046549)2.76202274
56gamma-aminobutyric acid signaling pathway (GO:0007214)2.76136136
57regulation of collateral sprouting (GO:0048670)2.76011191
58membrane depolarization (GO:0051899)2.75548151
59mechanosensory behavior (GO:0007638)2.74944665
60axoneme assembly (GO:0035082)2.73582965
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73335291
62response to auditory stimulus (GO:0010996)2.72635747
63synaptic vesicle exocytosis (GO:0016079)2.72395540
64nucleobase catabolic process (GO:0046113)2.72302636
65indole-containing compound metabolic process (GO:0042430)2.71540603
66cerebral cortex radially oriented cell migration (GO:0021799)2.70227640
67righting reflex (GO:0060013)2.69402483
68negative regulation of astrocyte differentiation (GO:0048712)2.69029670
69regulation of neurotransmitter uptake (GO:0051580)2.68007329
70synapse assembly (GO:0007416)2.67577699
71protein localization to cilium (GO:0061512)2.67444835
72neuromuscular synaptic transmission (GO:0007274)2.66748615
73behavioral response to ethanol (GO:0048149)2.65088060
74regulation of action potential (GO:0098900)2.64757714
75multicellular organismal signaling (GO:0035637)2.64675898
76cilium or flagellum-dependent cell motility (GO:0001539)2.61718228
77regulation of postsynaptic membrane potential (GO:0060078)2.60701924
78adult walking behavior (GO:0007628)2.60154151
79action potential (GO:0001508)2.59601548
80regulation of synaptic transmission, glutamatergic (GO:0051966)2.57511069
81fear response (GO:0042596)2.55744826
82positive regulation of action potential (GO:0045760)2.55289350
83spinal cord motor neuron differentiation (GO:0021522)2.54886079
84detection of light stimulus involved in sensory perception (GO:0050962)2.54055048
85detection of light stimulus involved in visual perception (GO:0050908)2.54055048
86regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53842949
87adult behavior (GO:0030534)2.53741765
88C4-dicarboxylate transport (GO:0015740)2.53593577
89cell migration in hindbrain (GO:0021535)2.53470262
90regulation of neurotransmitter levels (GO:0001505)2.49860514
91positive regulation of sodium ion transmembrane transport (GO:1902307)2.49796819
92positive regulation of membrane potential (GO:0045838)2.49580454
93cerebellar Purkinje cell differentiation (GO:0021702)2.49553344
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.49483163
95negative regulation of systemic arterial blood pressure (GO:0003085)2.48235554
96neuron recognition (GO:0008038)2.47076979
97neural tube formation (GO:0001841)2.45334365
98neurotransmitter transport (GO:0006836)2.45190249
99cilium movement (GO:0003341)2.45031690
100behavioral defense response (GO:0002209)2.44767933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05725900
2GBX2_23144817_ChIP-Seq_PC3_Human3.79527671
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72176278
4VDR_22108803_ChIP-Seq_LS180_Human2.46385321
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44522673
6ZNF274_21170338_ChIP-Seq_K562_Hela2.44006730
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26230465
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21008426
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10095469
10REST_21632747_ChIP-Seq_MESCs_Mouse2.07668890
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07166520
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.01008227
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00977592
14DROSHA_22980978_ChIP-Seq_HELA_Human1.98725345
15TAF15_26573619_Chip-Seq_HEK293_Human1.98206432
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97508248
17IGF1R_20145208_ChIP-Seq_DFB_Human1.97393420
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.97256709
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94920712
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94840306
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94255231
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.93862415
23P300_19829295_ChIP-Seq_ESCs_Human1.90133195
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88113241
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.87490986
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86570838
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.80834639
28FUS_26573619_Chip-Seq_HEK293_Human1.76057312
29SMAD4_21799915_ChIP-Seq_A2780_Human1.75694474
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71868909
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71225508
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70655871
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67050518
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66611841
35RNF2_27304074_Chip-Seq_NSC_Mouse1.61307124
36EWS_26573619_Chip-Seq_HEK293_Human1.58879370
37STAT3_23295773_ChIP-Seq_U87_Human1.57469923
38AR_21572438_ChIP-Seq_LNCaP_Human1.55629739
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55484543
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53464345
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.53234745
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52840486
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52840486
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.51601260
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.49034535
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48334603
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47367346
48ER_23166858_ChIP-Seq_MCF-7_Human1.47337359
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.46822602
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46453370
51TCF4_23295773_ChIP-Seq_U87_Human1.45615699
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45119615
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44667603
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43298004
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43117840
56AR_25329375_ChIP-Seq_VCAP_Human1.42854005
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42655245
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41024825
59BCAT_22108803_ChIP-Seq_LS180_Human1.39594864
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.39043543
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38582040
62CBP_20019798_ChIP-Seq_JUKART_Human1.38577302
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38577302
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.37146440
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36883016
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36883016
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36850412
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36015702
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29862296
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27405692
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26697656
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26299443
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22768464
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.22349266
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.21786277
76RUNX2_22187159_ChIP-Seq_PCA_Human1.21333427
77TCF4_22108803_ChIP-Seq_LS180_Human1.20220696
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19601710
79TP53_16413492_ChIP-PET_HCT116_Human1.18887969
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18758836
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16637405
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.15558181
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14108325
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13688132
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12467556
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.11438082
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11129644
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.10708227
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09646807
90KDM2B_26808549_Chip-Seq_REH_Human1.08866262
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08803123
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08425858
93P53_22387025_ChIP-Seq_ESCs_Mouse1.07488791
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.06620175
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06190367
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05671663
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.04630722
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.04578247
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03243651
100AR_19668381_ChIP-Seq_PC3_Human1.01417937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception3.16851805
2MP0003880_abnormal_central_pattern3.05139474
3MP0004859_abnormal_synaptic_plasticity2.97655443
4MP0009745_abnormal_behavioral_response2.92698802
5MP0009780_abnormal_chondrocyte_physiolo2.86475949
6MP0009046_muscle_twitch2.80368366
7MP0001486_abnormal_startle_reflex2.73510294
8MP0003635_abnormal_synaptic_transmissio2.72305060
9MP0002736_abnormal_nociception_after2.71049628
10MP0004270_analgesia2.64032867
11MP0001501_abnormal_sleep_pattern2.55283546
12MP0002272_abnormal_nervous_system2.51823281
13MP0002064_seizures2.41162146
14MP0002734_abnormal_mechanical_nocicepti2.26357298
15MP0002063_abnormal_learning/memory/cond2.26184596
16MP0002572_abnormal_emotion/affect_behav2.15366593
17MP0002735_abnormal_chemical_nociception2.13364571
18MP0000569_abnormal_digit_pigmentation2.10957875
19MP0005551_abnormal_eye_electrophysiolog2.09001556
20MP0002102_abnormal_ear_morphology2.08904181
21MP0001984_abnormal_olfaction2.00768262
22MP0004142_abnormal_muscle_tone1.98975378
23MP0005423_abnormal_somatic_nervous1.98895267
24MP0005646_abnormal_pituitary_gland1.92273671
25MP0008872_abnormal_physiological_respon1.88079363
26MP0003787_abnormal_imprinting1.85986888
27MP0002653_abnormal_ependyma_morphology1.79976070
28MP0004043_abnormal_pH_regulation1.77634867
29MP0004885_abnormal_endolymph1.76841238
30MP0002067_abnormal_sensory_capabilities1.72666969
31MP0002557_abnormal_social/conspecific_i1.70177835
32MP0000778_abnormal_nervous_system1.66620539
33MP0001970_abnormal_pain_threshold1.65834533
34MP0003195_calcinosis1.64273585
35MP0006276_abnormal_autonomic_nervous1.58773711
36MP0005386_behavior/neurological_phenoty1.56279264
37MP0004924_abnormal_behavior1.56279264
38MP0008877_abnormal_DNA_methylation1.55594522
39MP0001485_abnormal_pinna_reflex1.55445530
40MP0002733_abnormal_thermal_nociception1.55176551
41MP0004742_abnormal_vestibular_system1.48903704
42MP0004145_abnormal_muscle_electrophysio1.40681872
43MP0002638_abnormal_pupillary_reflex1.36523140
44MP0000631_abnormal_neuroendocrine_gland1.33422928
45MP0001529_abnormal_vocalization1.33238381
46MP0002184_abnormal_innervation1.32038732
47MP0004147_increased_porphyrin_level1.28456305
48MP0001440_abnormal_grooming_behavior1.28135711
49MP0006072_abnormal_retinal_apoptosis1.27248651
50MP0002882_abnormal_neuron_morphology1.24663624
51MP0005253_abnormal_eye_physiology1.22726090
52MP0000427_abnormal_hair_cycle1.22527538
53MP0001502_abnormal_circadian_rhythm1.20903495
54MP0005645_abnormal_hypothalamus_physiol1.20538508
55MP0002837_dystrophic_cardiac_calcinosis1.18375272
56MP0000955_abnormal_spinal_cord1.16440566
57MP0008569_lethality_at_weaning1.14905827
58MP0003646_muscle_fatigue1.11240157
59MP0002066_abnormal_motor_capabilities/c1.07230403
60MP0006292_abnormal_olfactory_placode1.06897104
61MP0005377_hearing/vestibular/ear_phenot1.06862237
62MP0003878_abnormal_ear_physiology1.06862237
63MP0001963_abnormal_hearing_physiology1.06383075
64MP0002752_abnormal_somatic_nervous1.06187831
65MP0002234_abnormal_pharynx_morphology1.03726845
66MP0003879_abnormal_hair_cell1.02453215
67MP0004133_heterotaxia1.01783659
68MP0005499_abnormal_olfactory_system1.01109584
69MP0005394_taste/olfaction_phenotype1.01109584
70MP0001986_abnormal_taste_sensitivity0.99850812
71MP0003633_abnormal_nervous_system0.99340335
72MP0002229_neurodegeneration0.98958527
73MP0004215_abnormal_myocardial_fiber0.97872918
74MP0001905_abnormal_dopamine_level0.95410947
75MP0002876_abnormal_thyroid_physiology0.94535901
76MP0002822_catalepsy0.94025281
77MP0002751_abnormal_autonomic_nervous0.93061906
78MP0003122_maternal_imprinting0.92673609
79MP0004811_abnormal_neuron_physiology0.92466398
80MP0002938_white_spotting0.91528248
81MP0000026_abnormal_inner_ear0.89071679
82MP0002909_abnormal_adrenal_gland0.87912660
83MP0005187_abnormal_penis_morphology0.85922168
84MP0003631_nervous_system_phenotype0.84722226
85MP0008875_abnormal_xenobiotic_pharmacok0.83996178
86MP0000383_abnormal_hair_follicle0.83701547
87MP0002152_abnormal_brain_morphology0.83240843
88MP0002069_abnormal_eating/drinking_beha0.79656320
89MP0004085_abnormal_heartbeat0.79069445
90MP0005503_abnormal_tendon_morphology0.78881962
91MP0005195_abnormal_posterior_eye0.78844227
92MP0001177_atelectasis0.78327296
93MP0003890_abnormal_embryonic-extraembry0.78228628
94MP0002163_abnormal_gland_morphology0.77355294
95MP0002277_abnormal_respiratory_mucosa0.76114956
96MP0003136_yellow_coat_color0.75592840
97MP0003137_abnormal_impulse_conducting0.74587713
98MP0000049_abnormal_middle_ear0.72798986
99MP0000230_abnormal_systemic_arterial0.72401449
100MP0010386_abnormal_urinary_bladder0.71924742

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.66540798
2Hyperventilation (HP:0002883)4.49471481
3Febrile seizures (HP:0002373)4.23545466
4Focal seizures (HP:0007359)4.15251510
5Progressive cerebellar ataxia (HP:0002073)4.11532063
6Genetic anticipation (HP:0003743)3.79085864
7Gaze-evoked nystagmus (HP:0000640)3.72325009
8Pancreatic cysts (HP:0001737)3.71820163
9Pancreatic fibrosis (HP:0100732)3.59786422
10Abnormality of midbrain morphology (HP:0002418)3.52794910
11Molar tooth sign on MRI (HP:0002419)3.52794910
12True hermaphroditism (HP:0010459)3.47420735
13Nephronophthisis (HP:0000090)3.42620027
14Atonic seizures (HP:0010819)3.21277681
15Limb dystonia (HP:0002451)3.18494675
16Broad-based gait (HP:0002136)3.16643355
17Congenital stationary night blindness (HP:0007642)2.93873416
18Dialeptic seizures (HP:0011146)2.93147981
19Abnormality of the renal medulla (HP:0100957)2.92353385
20Epileptic encephalopathy (HP:0200134)2.91836956
21Medial flaring of the eyebrow (HP:0010747)2.86539638
22Absent/shortened dynein arms (HP:0200106)2.84454732
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.84454732
24Cystic liver disease (HP:0006706)2.83407789
25Gait imbalance (HP:0002141)2.79424751
26Chronic hepatic failure (HP:0100626)2.76902240
27Hemiparesis (HP:0001269)2.75794435
28Abnormality of the renal cortex (HP:0011035)2.70133801
29Absent speech (HP:0001344)2.67516930
30Myokymia (HP:0002411)2.66450867
31Absence seizures (HP:0002121)2.58305670
32Generalized tonic-clonic seizures (HP:0002069)2.53333274
33Inability to walk (HP:0002540)2.48473067
34Protruding tongue (HP:0010808)2.46893018
35Abnormal respiratory epithelium morphology (HP:0012253)2.42181127
36Abnormal respiratory motile cilium morphology (HP:0005938)2.42181127
37Tubular atrophy (HP:0000092)2.36971662
38Abnormal ciliary motility (HP:0012262)2.36736056
39Polydipsia (HP:0001959)2.35661349
40Abnormal drinking behavior (HP:0030082)2.35661349
41Congenital primary aphakia (HP:0007707)2.35555958
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.35078640
43Hypoplasia of the fovea (HP:0007750)2.35078640
44Bilateral microphthalmos (HP:0007633)2.33935673
45Action tremor (HP:0002345)2.33864250
46Drooling (HP:0002307)2.31842586
47Hypothermia (HP:0002045)2.31519888
48Type II lissencephaly (HP:0007260)2.28506807
49Genital tract atresia (HP:0001827)2.20715345
50Furrowed tongue (HP:0000221)2.18190458
51Abolished electroretinogram (ERG) (HP:0000550)2.16605963
52Attenuation of retinal blood vessels (HP:0007843)2.15447225
53Vaginal atresia (HP:0000148)2.15383558
54Nephrogenic diabetes insipidus (HP:0009806)2.15069104
55Abnormality of binocular vision (HP:0011514)2.14546296
56Diplopia (HP:0000651)2.14546296
57Occipital encephalocele (HP:0002085)2.12528570
58Epileptiform EEG discharges (HP:0011182)2.09997746
59Anencephaly (HP:0002323)2.09462750
60Impaired smooth pursuit (HP:0007772)2.07546875
61Excessive salivation (HP:0003781)2.04815347
62Lissencephaly (HP:0001339)2.01972268
63Abnormal respiratory motile cilium physiology (HP:0012261)2.00472484
64Progressive inability to walk (HP:0002505)2.00381187
65EEG with generalized epileptiform discharges (HP:0011198)1.98742193
66Hypsarrhythmia (HP:0002521)1.97389543
67Postaxial foot polydactyly (HP:0001830)1.96527058
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95168290
69Prolonged QT interval (HP:0001657)1.95160438
70Abnormality of the fovea (HP:0000493)1.94808932
71Sclerocornea (HP:0000647)1.93599575
72Increased corneal curvature (HP:0100692)1.91907797
73Keratoconus (HP:0000563)1.91907797
74Hemiplegia (HP:0002301)1.91442984
75Poor coordination (HP:0002370)1.90647768
76Decreased central vision (HP:0007663)1.88763543
77Dysdiadochokinesis (HP:0002075)1.88504271
78Midline defect of the nose (HP:0004122)1.86784516
79Polyuria (HP:0000103)1.86113907
80Congenital hepatic fibrosis (HP:0002612)1.85820265
81Congenital, generalized hypertrichosis (HP:0004540)1.84820467
82Pendular nystagmus (HP:0012043)1.83010104
83Status epilepticus (HP:0002133)1.82683850
84Intestinal atresia (HP:0011100)1.80589530
85Urinary bladder sphincter dysfunction (HP:0002839)1.80518822
86Pachygyria (HP:0001302)1.80450988
87Abnormality of the pubic bones (HP:0003172)1.80431065
88Renal cortical cysts (HP:0000803)1.78919896
89Congenital sensorineural hearing impairment (HP:0008527)1.78700076
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.77291230
91Decreased circulating renin level (HP:0003351)1.75117474
92Abnormality of ocular smooth pursuit (HP:0000617)1.74646554
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73333554
94Abnormal eating behavior (HP:0100738)1.72398874
95Morphological abnormality of the pyramidal tract (HP:0002062)1.71097052
96Visual hallucinations (HP:0002367)1.70947988
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.70811044
98Agitation (HP:0000713)1.68458443
99Optic nerve hypoplasia (HP:0000609)1.67972633
100Hyperalaninemia (HP:0003348)1.67486113

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.97285841
2MARK13.40556306
3DAPK23.28865762
4NTRK32.84873100
5CASK2.74864464
6MAPK132.58737300
7WNK32.43210473
8EPHA42.41960510
9PINK12.13931318
10ADRBK22.10570682
11MAP4K21.95254730
12NTRK21.83182293
13FGFR21.77993489
14BMPR1B1.72361828
15GRK11.69785261
16MAP3K41.64908424
17INSRR1.64406667
18CAMKK21.57228477
19ACVR1B1.53104806
20OXSR11.48216448
21PAK31.38278857
22PHKG11.38106384
23PHKG21.38106384
24MKNK21.37800135
25TNIK1.33322573
26PRKCG1.29789463
27PLK21.28622335
28WNK41.13546955
29UHMK11.11006976
30CAMKK11.10948288
31STK391.10778229
32SGK21.09036782
33CAMK2A1.08562538
34BCR1.08516449
35PAK61.06012535
36SGK2231.03807376
37SGK4941.03807376
38ZAK1.02313154
39DYRK1A0.99640205
40NUAK10.99527593
41DYRK20.97993711
42CAMK10.97753803
43PTK2B0.97543837
44MAPK150.96936443
45MINK10.96645041
46TAOK30.96357833
47PRKCE0.95962282
48TLK10.94386024
49ADRBK10.93012938
50STK110.91947693
51PKN10.88597547
52CDK50.84011330
53CAMK2B0.81379314
54PNCK0.81040177
55SIK20.80631717
56CAMK40.77237219
57MAP2K70.71766554
58CSNK1G20.70788835
59STK38L0.69769075
60AKT30.67682535
61PRKCH0.64973131
62SGK10.63077699
63MAPKAPK50.62827488
64GRK50.62812120
65PRKCZ0.61793017
66NME10.58645417
67ERBB20.57525945
68OBSCN0.57055079
69CSNK1G10.57045086
70DAPK10.55401522
71PIK3CA0.54797483
72CAMK2D0.53064077
73PRKACA0.52684274
74PRKAA10.51549428
75ERBB30.49939304
76MAP2K60.49391421
77CSNK1A10.48975059
78WNK10.47076921
79RPS6KA30.47006115
80MAPKAPK30.46779117
81MAP3K70.43228536
82CSNK1D0.42841930
83CSNK1G30.42530168
84PRKG10.42283554
85LATS10.42190217
86EPHB20.39324402
87PRKCA0.38986100
88CAMK2G0.38463887
89MKNK10.38327955
90MAP2K40.37149598
91SGK30.35932878
92TYRO30.34249892
93MAP2K10.34121616
94ROCK10.33885421
95TRIM280.33822993
96CCNB10.33338621
97RPS6KA60.33131903
98CSNK1A1L0.32527304
99TXK0.32499136
100PRKCB0.30073740

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26884667
2Glutamatergic synapse_Homo sapiens_hsa047242.61452142
3Morphine addiction_Homo sapiens_hsa050322.49981420
4Circadian entrainment_Homo sapiens_hsa047132.41744798
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34649870
6GABAergic synapse_Homo sapiens_hsa047272.34094553
7Phototransduction_Homo sapiens_hsa047442.33329717
8Taste transduction_Homo sapiens_hsa047422.25342222
9Insulin secretion_Homo sapiens_hsa049112.23564255
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20484205
11Amphetamine addiction_Homo sapiens_hsa050312.05188880
12Linoleic acid metabolism_Homo sapiens_hsa005912.00825144
13Salivary secretion_Homo sapiens_hsa049701.98405640
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97736188
15Synaptic vesicle cycle_Homo sapiens_hsa047211.85946089
16Cocaine addiction_Homo sapiens_hsa050301.83971956
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81442417
18Dopaminergic synapse_Homo sapiens_hsa047281.79342390
19Calcium signaling pathway_Homo sapiens_hsa040201.63613192
20Butanoate metabolism_Homo sapiens_hsa006501.62814511
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.62353403
22Serotonergic synapse_Homo sapiens_hsa047261.61567674
23Ether lipid metabolism_Homo sapiens_hsa005651.55587925
24Nitrogen metabolism_Homo sapiens_hsa009101.52525055
25Olfactory transduction_Homo sapiens_hsa047401.48980619
26Tryptophan metabolism_Homo sapiens_hsa003801.40853022
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38564311
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37953993
29Cholinergic synapse_Homo sapiens_hsa047251.36865160
30Renin secretion_Homo sapiens_hsa049241.35274293
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33264719
32Gastric acid secretion_Homo sapiens_hsa049711.31403726
33Long-term depression_Homo sapiens_hsa047301.29903458
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23934879
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22997160
36cAMP signaling pathway_Homo sapiens_hsa040241.20947941
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17248205
38Selenocompound metabolism_Homo sapiens_hsa004501.14063293
39Oxytocin signaling pathway_Homo sapiens_hsa049211.13224286
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12435811
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.08470100
42ABC transporters_Homo sapiens_hsa020101.06328683
43Cardiac muscle contraction_Homo sapiens_hsa042601.04331992
44Long-term potentiation_Homo sapiens_hsa047200.97949413
45Ovarian steroidogenesis_Homo sapiens_hsa049130.97615681
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97444309
47Dorso-ventral axis formation_Homo sapiens_hsa043200.96671852
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94249723
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93067133
50Propanoate metabolism_Homo sapiens_hsa006400.91934437
51Histidine metabolism_Homo sapiens_hsa003400.89603488
52Collecting duct acid secretion_Homo sapiens_hsa049660.81973989
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81781908
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80452478
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80062474
56Caffeine metabolism_Homo sapiens_hsa002320.79795622
57Axon guidance_Homo sapiens_hsa043600.79722943
58Circadian rhythm_Homo sapiens_hsa047100.79229538
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.78948089
60Type II diabetes mellitus_Homo sapiens_hsa049300.77151448
61beta-Alanine metabolism_Homo sapiens_hsa004100.74456685
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73829568
63Pancreatic secretion_Homo sapiens_hsa049720.72637834
64Chemical carcinogenesis_Homo sapiens_hsa052040.70680156
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.67447839
66Regulation of autophagy_Homo sapiens_hsa041400.65849297
67Oxidative phosphorylation_Homo sapiens_hsa001900.61321847
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61222786
69Mineral absorption_Homo sapiens_hsa049780.61190143
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61000153
71Sphingolipid metabolism_Homo sapiens_hsa006000.60013851
72Retinol metabolism_Homo sapiens_hsa008300.59951361
73Thyroid hormone synthesis_Homo sapiens_hsa049180.59742534
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58622074
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56605640
76Arachidonic acid metabolism_Homo sapiens_hsa005900.55634224
77Peroxisome_Homo sapiens_hsa041460.54996314
78Bile secretion_Homo sapiens_hsa049760.53590476
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52490112
80Glycerolipid metabolism_Homo sapiens_hsa005610.50875367
81Ras signaling pathway_Homo sapiens_hsa040140.50789339
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48197472
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46973916
84Hippo signaling pathway_Homo sapiens_hsa043900.45136973
85Hedgehog signaling pathway_Homo sapiens_hsa043400.44812151
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44804125
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42878232
88Parkinsons disease_Homo sapiens_hsa050120.42434738
89Alzheimers disease_Homo sapiens_hsa050100.41879851
90Melanogenesis_Homo sapiens_hsa049160.41578667
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40092401
92Basal transcription factors_Homo sapiens_hsa030220.39883096
93Fatty acid biosynthesis_Homo sapiens_hsa000610.38219947
94Gap junction_Homo sapiens_hsa045400.36292592
95MAPK signaling pathway_Homo sapiens_hsa040100.34828394
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.34396722
97Dilated cardiomyopathy_Homo sapiens_hsa054140.31823033
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30295338
99Huntingtons disease_Homo sapiens_hsa050160.28355733
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.27584764

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