ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.30073159
2	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.04161730
3	gamma-aminobutyric acid transport (GO:0015812)	3.97994675
4	presynaptic membrane assembly (GO:0097105)	3.93612666
5	postsynaptic membrane organization (GO:0001941)	3.88369799
6	dendritic spine morphogenesis (GO:0060997)	3.80406421
7	transmission of nerve impulse (GO:0019226)	3.78442574
8	behavioral response to nicotine (GO:0035095)	3.77758504
9	presynaptic membrane organization (GO:0097090)	3.75660904
10	vocalization behavior (GO:0071625)	3.72267103
11	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.67908192
12	neuronal action potential propagation (GO:0019227)	3.67242906
13	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.64773966
14	glutamate receptor signaling pathway (GO:0007215)	3.57685244
15	membrane depolarization during action potential (GO:0086010)	3.54984924
16	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.45787775
17	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.45178454
18	proline transport (GO:0015824)	3.44004523
19	adrenergic receptor signaling pathway (GO:0071875)	3.42518925
20	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.40472642
21	synaptic transmission, glutamatergic (GO:0035249)	3.38557905
22	synaptic vesicle maturation (GO:0016188)	3.35331501
23	protein localization to synapse (GO:0035418)	3.31307202
24	auditory behavior (GO:0031223)	3.31161916
25	neuronal action potential (GO:0019228)	3.25028522
26	neuron cell-cell adhesion (GO:0007158)	3.22663128
27	serotonin metabolic process (GO:0042428)	3.19634594
28	neurotransmitter-gated ion channel clustering (GO:0072578)	3.16954706
29	neuron-neuron synaptic transmission (GO:0007270)	3.13000731
30	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.12713625
31	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.10764087
32	primary amino compound metabolic process (GO:1901160)	3.07702171
33	pyrimidine nucleobase catabolic process (GO:0006208)	3.07233721
34	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.07029858
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.98733261
36	startle response (GO:0001964)	2.95767480
37	central nervous system projection neuron axonogenesis (GO:0021952)	2.95347322
38	reflex (GO:0060004)	2.95071070
39	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.93606523
40	neurotransmitter secretion (GO:0007269)	2.91283617
41	negative regulation of dendrite development (GO:2000171)	2.91040898
42	central nervous system neuron axonogenesis (GO:0021955)	2.84931570
43	indolalkylamine metabolic process (GO:0006586)	2.83665066
44	glutamate secretion (GO:0014047)	2.82652997
45	tryptophan catabolic process (GO:0006569)	2.82562197
46	indole-containing compound catabolic process (GO:0042436)	2.82562197
47	indolalkylamine catabolic process (GO:0046218)	2.82562197
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81609779
49	kynurenine metabolic process (GO:0070189)	2.81552806
50	fucose catabolic process (GO:0019317)	2.80194255
51	L-fucose metabolic process (GO:0042354)	2.80194255
52	L-fucose catabolic process (GO:0042355)	2.80194255
53	response to pheromone (GO:0019236)	2.77793491
54	glycosphingolipid biosynthetic process (GO:0006688)	2.77019829
55	retinal cone cell development (GO:0046549)	2.76202274
56	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.76136136
57	regulation of collateral sprouting (GO:0048670)	2.76011191
58	membrane depolarization (GO:0051899)	2.75548151
59	mechanosensory behavior (GO:0007638)	2.74944665
60	axoneme assembly (GO:0035082)	2.73582965
61	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.73335291
62	response to auditory stimulus (GO:0010996)	2.72635747
63	synaptic vesicle exocytosis (GO:0016079)	2.72395540
64	nucleobase catabolic process (GO:0046113)	2.72302636
65	indole-containing compound metabolic process (GO:0042430)	2.71540603
66	cerebral cortex radially oriented cell migration (GO:0021799)	2.70227640
67	righting reflex (GO:0060013)	2.69402483
68	negative regulation of astrocyte differentiation (GO:0048712)	2.69029670
69	regulation of neurotransmitter uptake (GO:0051580)	2.68007329
70	synapse assembly (GO:0007416)	2.67577699
71	protein localization to cilium (GO:0061512)	2.67444835
72	neuromuscular synaptic transmission (GO:0007274)	2.66748615
73	behavioral response to ethanol (GO:0048149)	2.65088060
74	regulation of action potential (GO:0098900)	2.64757714
75	multicellular organismal signaling (GO:0035637)	2.64675898
76	cilium or flagellum-dependent cell motility (GO:0001539)	2.61718228
77	regulation of postsynaptic membrane potential (GO:0060078)	2.60701924
78	adult walking behavior (GO:0007628)	2.60154151
79	action potential (GO:0001508)	2.59601548
80	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.57511069
81	fear response (GO:0042596)	2.55744826
82	positive regulation of action potential (GO:0045760)	2.55289350
83	spinal cord motor neuron differentiation (GO:0021522)	2.54886079
84	detection of light stimulus involved in sensory perception (GO:0050962)	2.54055048
85	detection of light stimulus involved in visual perception (GO:0050908)	2.54055048
86	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.53842949
87	adult behavior (GO:0030534)	2.53741765
88	C4-dicarboxylate transport (GO:0015740)	2.53593577
89	cell migration in hindbrain (GO:0021535)	2.53470262
90	regulation of neurotransmitter levels (GO:0001505)	2.49860514
91	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.49796819
92	positive regulation of membrane potential (GO:0045838)	2.49580454
93	cerebellar Purkinje cell differentiation (GO:0021702)	2.49553344
94	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.49483163
95	negative regulation of systemic arterial blood pressure (GO:0003085)	2.48235554
96	neuron recognition (GO:0008038)	2.47076979
97	neural tube formation (GO:0001841)	2.45334365
98	neurotransmitter transport (GO:0006836)	2.45190249
99	cilium movement (GO:0003341)	2.45031690
100	behavioral defense response (GO:0002209)	2.44767933

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.05725900
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.79527671
3	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.72176278
4	VDR_22108803_ChIP-Seq_LS180_Human	2.46385321
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.44522673
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.44006730
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26230465
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21008426
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10095469
10	REST_21632747_ChIP-Seq_MESCs_Mouse	2.07668890
11	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.07166520
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.01008227
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.00977592
14	DROSHA_22980978_ChIP-Seq_HELA_Human	1.98725345
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.98206432
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97508248
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97393420
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.97256709
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.94920712
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.94840306
21	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.94255231
22	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93862415
23	P300_19829295_ChIP-Seq_ESCs_Human	1.90133195
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.88113241
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.87490986
26	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.86570838
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.80834639
28	FUS_26573619_Chip-Seq_HEK293_Human	1.76057312
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75694474
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71868909
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.71225508
32	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.70655871
33	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.67050518
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66611841
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.61307124
36	EWS_26573619_Chip-Seq_HEK293_Human	1.58879370
37	STAT3_23295773_ChIP-Seq_U87_Human	1.57469923
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.55629739
39	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.55484543
40	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.53464345
41	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53234745
42	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.52840486
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.52840486
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51601260
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.49034535
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48334603
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47367346
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.47337359
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.46822602
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.46453370
51	TCF4_23295773_ChIP-Seq_U87_Human	1.45615699
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45119615
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44667603
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43298004
55	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.43117840
56	AR_25329375_ChIP-Seq_VCAP_Human	1.42854005
57	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42655245
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41024825
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.39594864
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.39043543
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38582040
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.38577302
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38577302
64	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37146440
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36883016
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36883016
67	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.36850412
68	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.36015702
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.29862296
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27405692
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26697656
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26299443
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22768464
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.22349266
75	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21786277
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21333427
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.20220696
78	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19601710
79	TP53_16413492_ChIP-PET_HCT116_Human	1.18887969
80	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.18758836
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16637405
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15558181
83	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.14108325
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13688132
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12467556
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11438082
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11129644
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10708227
89	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.09646807
90	KDM2B_26808549_Chip-Seq_REH_Human	1.08866262
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08803123
92	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.08425858
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07488791
94	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06620175
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06190367
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05671663
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04630722
98	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04578247
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03243651
100	AR_19668381_ChIP-Seq_PC3_Human	1.01417937

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	3.16851805
2	MP0003880_abnormal_central_pattern	3.05139474
3	MP0004859_abnormal_synaptic_plasticity	2.97655443
4	MP0009745_abnormal_behavioral_response	2.92698802
5	MP0009780_abnormal_chondrocyte_physiolo	2.86475949
6	MP0009046_muscle_twitch	2.80368366
7	MP0001486_abnormal_startle_reflex	2.73510294
8	MP0003635_abnormal_synaptic_transmissio	2.72305060
9	MP0002736_abnormal_nociception_after	2.71049628
10	MP0004270_analgesia	2.64032867
11	MP0001501_abnormal_sleep_pattern	2.55283546
12	MP0002272_abnormal_nervous_system	2.51823281
13	MP0002064_seizures	2.41162146
14	MP0002734_abnormal_mechanical_nocicepti	2.26357298
15	MP0002063_abnormal_learning/memory/cond	2.26184596
16	MP0002572_abnormal_emotion/affect_behav	2.15366593
17	MP0002735_abnormal_chemical_nociception	2.13364571
18	MP0000569_abnormal_digit_pigmentation	2.10957875
19	MP0005551_abnormal_eye_electrophysiolog	2.09001556
20	MP0002102_abnormal_ear_morphology	2.08904181
21	MP0001984_abnormal_olfaction	2.00768262
22	MP0004142_abnormal_muscle_tone	1.98975378
23	MP0005423_abnormal_somatic_nervous	1.98895267
24	MP0005646_abnormal_pituitary_gland	1.92273671
25	MP0008872_abnormal_physiological_respon	1.88079363
26	MP0003787_abnormal_imprinting	1.85986888
27	MP0002653_abnormal_ependyma_morphology	1.79976070
28	MP0004043_abnormal_pH_regulation	1.77634867
29	MP0004885_abnormal_endolymph	1.76841238
30	MP0002067_abnormal_sensory_capabilities	1.72666969
31	MP0002557_abnormal_social/conspecific_i	1.70177835
32	MP0000778_abnormal_nervous_system	1.66620539
33	MP0001970_abnormal_pain_threshold	1.65834533
34	MP0003195_calcinosis	1.64273585
35	MP0006276_abnormal_autonomic_nervous	1.58773711
36	MP0004924_abnormal_behavior	1.56279264
37	MP0005386_behavior/neurological_phenoty	1.56279264
38	MP0008877_abnormal_DNA_methylation	1.55594522
39	MP0001485_abnormal_pinna_reflex	1.55445530
40	MP0002733_abnormal_thermal_nociception	1.55176551
41	MP0004742_abnormal_vestibular_system	1.48903704
42	MP0004145_abnormal_muscle_electrophysio	1.40681872
43	MP0002638_abnormal_pupillary_reflex	1.36523140
44	MP0000631_abnormal_neuroendocrine_gland	1.33422928
45	MP0001529_abnormal_vocalization	1.33238381
46	MP0002184_abnormal_innervation	1.32038732
47	MP0004147_increased_porphyrin_level	1.28456305
48	MP0001440_abnormal_grooming_behavior	1.28135711
49	MP0006072_abnormal_retinal_apoptosis	1.27248651
50	MP0002882_abnormal_neuron_morphology	1.24663624
51	MP0005253_abnormal_eye_physiology	1.22726090
52	MP0000427_abnormal_hair_cycle	1.22527538
53	MP0001502_abnormal_circadian_rhythm	1.20903495
54	MP0005645_abnormal_hypothalamus_physiol	1.20538508
55	MP0002837_dystrophic_cardiac_calcinosis	1.18375272
56	MP0000955_abnormal_spinal_cord	1.16440566
57	MP0008569_lethality_at_weaning	1.14905827
58	MP0003646_muscle_fatigue	1.11240157
59	MP0002066_abnormal_motor_capabilities/c	1.07230403
60	MP0006292_abnormal_olfactory_placode	1.06897104
61	MP0005377_hearing/vestibular/ear_phenot	1.06862237
62	MP0003878_abnormal_ear_physiology	1.06862237
63	MP0001963_abnormal_hearing_physiology	1.06383075
64	MP0002752_abnormal_somatic_nervous	1.06187831
65	MP0002234_abnormal_pharynx_morphology	1.03726845
66	MP0003879_abnormal_hair_cell	1.02453215
67	MP0004133_heterotaxia	1.01783659
68	MP0005394_taste/olfaction_phenotype	1.01109584
69	MP0005499_abnormal_olfactory_system	1.01109584
70	MP0001986_abnormal_taste_sensitivity	0.99850812
71	MP0003633_abnormal_nervous_system	0.99340335
72	MP0002229_neurodegeneration	0.98958527
73	MP0004215_abnormal_myocardial_fiber	0.97872918
74	MP0001905_abnormal_dopamine_level	0.95410947
75	MP0002876_abnormal_thyroid_physiology	0.94535901
76	MP0002822_catalepsy	0.94025281
77	MP0002751_abnormal_autonomic_nervous	0.93061906
78	MP0003122_maternal_imprinting	0.92673609
79	MP0004811_abnormal_neuron_physiology	0.92466398
80	MP0002938_white_spotting	0.91528248
81	MP0000026_abnormal_inner_ear	0.89071679
82	MP0002909_abnormal_adrenal_gland	0.87912660
83	MP0005187_abnormal_penis_morphology	0.85922168
84	MP0003631_nervous_system_phenotype	0.84722226
85	MP0008875_abnormal_xenobiotic_pharmacok	0.83996178
86	MP0000383_abnormal_hair_follicle	0.83701547
87	MP0002152_abnormal_brain_morphology	0.83240843
88	MP0002069_abnormal_eating/drinking_beha	0.79656320
89	MP0004085_abnormal_heartbeat	0.79069445
90	MP0005503_abnormal_tendon_morphology	0.78881962
91	MP0005195_abnormal_posterior_eye	0.78844227
92	MP0001177_atelectasis	0.78327296
93	MP0003890_abnormal_embryonic-extraembry	0.78228628
94	MP0002163_abnormal_gland_morphology	0.77355294
95	MP0002277_abnormal_respiratory_mucosa	0.76114956
96	MP0003136_yellow_coat_color	0.75592840
97	MP0003137_abnormal_impulse_conducting	0.74587713
98	MP0000049_abnormal_middle_ear	0.72798986
99	MP0000230_abnormal_systemic_arterial	0.72401449
100	MP0010386_abnormal_urinary_bladder	0.71924742

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	4.66540798
2	Hyperventilation (HP:0002883)	4.49471481
3	Febrile seizures (HP:0002373)	4.23545466
4	Focal seizures (HP:0007359)	4.15251510
5	Progressive cerebellar ataxia (HP:0002073)	4.11532063
6	Genetic anticipation (HP:0003743)	3.79085864
7	Gaze-evoked nystagmus (HP:0000640)	3.72325009
8	Pancreatic cysts (HP:0001737)	3.71820163
9	Pancreatic fibrosis (HP:0100732)	3.59786422
10	Abnormality of midbrain morphology (HP:0002418)	3.52794910
11	Molar tooth sign on MRI (HP:0002419)	3.52794910
12	True hermaphroditism (HP:0010459)	3.47420735
13	Nephronophthisis (HP:0000090)	3.42620027
14	Atonic seizures (HP:0010819)	3.21277681
15	Limb dystonia (HP:0002451)	3.18494675
16	Broad-based gait (HP:0002136)	3.16643355
17	Congenital stationary night blindness (HP:0007642)	2.93873416
18	Dialeptic seizures (HP:0011146)	2.93147981
19	Abnormality of the renal medulla (HP:0100957)	2.92353385
20	Epileptic encephalopathy (HP:0200134)	2.91836956
21	Medial flaring of the eyebrow (HP:0010747)	2.86539638
22	Absent/shortened dynein arms (HP:0200106)	2.84454732
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.84454732
24	Cystic liver disease (HP:0006706)	2.83407789
25	Gait imbalance (HP:0002141)	2.79424751
26	Chronic hepatic failure (HP:0100626)	2.76902240
27	Hemiparesis (HP:0001269)	2.75794435
28	Abnormality of the renal cortex (HP:0011035)	2.70133801
29	Absent speech (HP:0001344)	2.67516930
30	Myokymia (HP:0002411)	2.66450867
31	Absence seizures (HP:0002121)	2.58305670
32	Generalized tonic-clonic seizures (HP:0002069)	2.53333274
33	Inability to walk (HP:0002540)	2.48473067
34	Protruding tongue (HP:0010808)	2.46893018
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.42181127
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.42181127
37	Tubular atrophy (HP:0000092)	2.36971662
38	Abnormal ciliary motility (HP:0012262)	2.36736056
39	Polydipsia (HP:0001959)	2.35661349
40	Abnormal drinking behavior (HP:0030082)	2.35661349
41	Congenital primary aphakia (HP:0007707)	2.35555958
42	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.35078640
43	Hypoplasia of the fovea (HP:0007750)	2.35078640
44	Bilateral microphthalmos (HP:0007633)	2.33935673
45	Action tremor (HP:0002345)	2.33864250
46	Drooling (HP:0002307)	2.31842586
47	Hypothermia (HP:0002045)	2.31519888
48	Type II lissencephaly (HP:0007260)	2.28506807
49	Genital tract atresia (HP:0001827)	2.20715345
50	Furrowed tongue (HP:0000221)	2.18190458
51	Abolished electroretinogram (ERG) (HP:0000550)	2.16605963
52	Attenuation of retinal blood vessels (HP:0007843)	2.15447225
53	Vaginal atresia (HP:0000148)	2.15383558
54	Nephrogenic diabetes insipidus (HP:0009806)	2.15069104
55	Abnormality of binocular vision (HP:0011514)	2.14546296
56	Diplopia (HP:0000651)	2.14546296
57	Occipital encephalocele (HP:0002085)	2.12528570
58	Epileptiform EEG discharges (HP:0011182)	2.09997746
59	Anencephaly (HP:0002323)	2.09462750
60	Impaired smooth pursuit (HP:0007772)	2.07546875
61	Excessive salivation (HP:0003781)	2.04815347
62	Lissencephaly (HP:0001339)	2.01972268
63	Abnormal respiratory motile cilium physiology (HP:0012261)	2.00472484
64	Progressive inability to walk (HP:0002505)	2.00381187
65	EEG with generalized epileptiform discharges (HP:0011198)	1.98742193
66	Hypsarrhythmia (HP:0002521)	1.97389543
67	Postaxial foot polydactyly (HP:0001830)	1.96527058
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.95168290
69	Prolonged QT interval (HP:0001657)	1.95160438
70	Abnormality of the fovea (HP:0000493)	1.94808932
71	Sclerocornea (HP:0000647)	1.93599575
72	Increased corneal curvature (HP:0100692)	1.91907797
73	Keratoconus (HP:0000563)	1.91907797
74	Hemiplegia (HP:0002301)	1.91442984
75	Poor coordination (HP:0002370)	1.90647768
76	Decreased central vision (HP:0007663)	1.88763543
77	Dysdiadochokinesis (HP:0002075)	1.88504271
78	Midline defect of the nose (HP:0004122)	1.86784516
79	Polyuria (HP:0000103)	1.86113907
80	Congenital hepatic fibrosis (HP:0002612)	1.85820265
81	Congenital, generalized hypertrichosis (HP:0004540)	1.84820467
82	Pendular nystagmus (HP:0012043)	1.83010104
83	Status epilepticus (HP:0002133)	1.82683850
84	Intestinal atresia (HP:0011100)	1.80589530
85	Urinary bladder sphincter dysfunction (HP:0002839)	1.80518822
86	Pachygyria (HP:0001302)	1.80450988
87	Abnormality of the pubic bones (HP:0003172)	1.80431065
88	Renal cortical cysts (HP:0000803)	1.78919896
89	Congenital sensorineural hearing impairment (HP:0008527)	1.78700076
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.77291230
91	Decreased circulating renin level (HP:0003351)	1.75117474
92	Abnormality of ocular smooth pursuit (HP:0000617)	1.74646554
93	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73333554
94	Abnormal eating behavior (HP:0100738)	1.72398874
95	Morphological abnormality of the pyramidal tract (HP:0002062)	1.71097052
96	Visual hallucinations (HP:0002367)	1.70947988
97	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.70811044
98	Agitation (HP:0000713)	1.68458443
99	Optic nerve hypoplasia (HP:0000609)	1.67972633
100	Hyperalaninemia (HP:0003348)	1.67486113

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.97285841
2	MARK1	3.40556306
3	DAPK2	3.28865762
4	NTRK3	2.84873100
5	CASK	2.74864464
6	MAPK13	2.58737300
7	WNK3	2.43210473
8	EPHA4	2.41960510
9	PINK1	2.13931318
10	ADRBK2	2.10570682
11	MAP4K2	1.95254730
12	NTRK2	1.83182293
13	FGFR2	1.77993489
14	BMPR1B	1.72361828
15	GRK1	1.69785261
16	MAP3K4	1.64908424
17	INSRR	1.64406667
18	CAMKK2	1.57228477
19	ACVR1B	1.53104806
20	OXSR1	1.48216448
21	PAK3	1.38278857
22	PHKG1	1.38106384
23	PHKG2	1.38106384
24	MKNK2	1.37800135
25	TNIK	1.33322573
26	PRKCG	1.29789463
27	PLK2	1.28622335
28	WNK4	1.13546955
29	UHMK1	1.11006976
30	CAMKK1	1.10948288
31	STK39	1.10778229
32	SGK2	1.09036782
33	CAMK2A	1.08562538
34	BCR	1.08516449
35	PAK6	1.06012535
36	SGK223	1.03807376
37	SGK494	1.03807376
38	ZAK	1.02313154
39	DYRK1A	0.99640205
40	NUAK1	0.99527593
41	DYRK2	0.97993711
42	CAMK1	0.97753803
43	PTK2B	0.97543837
44	MAPK15	0.96936443
45	MINK1	0.96645041
46	TAOK3	0.96357833
47	PRKCE	0.95962282
48	TLK1	0.94386024
49	ADRBK1	0.93012938
50	STK11	0.91947693
51	PKN1	0.88597547
52	CDK5	0.84011330
53	CAMK2B	0.81379314
54	PNCK	0.81040177
55	SIK2	0.80631717
56	CAMK4	0.77237219
57	MAP2K7	0.71766554
58	CSNK1G2	0.70788835
59	STK38L	0.69769075
60	AKT3	0.67682535
61	PRKCH	0.64973131
62	SGK1	0.63077699
63	MAPKAPK5	0.62827488
64	GRK5	0.62812120
65	PRKCZ	0.61793017
66	NME1	0.58645417
67	ERBB2	0.57525945
68	OBSCN	0.57055079
69	CSNK1G1	0.57045086
70	DAPK1	0.55401522
71	PIK3CA	0.54797483
72	CAMK2D	0.53064077
73	PRKACA	0.52684274
74	PRKAA1	0.51549428
75	ERBB3	0.49939304
76	MAP2K6	0.49391421
77	CSNK1A1	0.48975059
78	WNK1	0.47076921
79	RPS6KA3	0.47006115
80	MAPKAPK3	0.46779117
81	MAP3K7	0.43228536
82	CSNK1D	0.42841930
83	CSNK1G3	0.42530168
84	PRKG1	0.42283554
85	LATS1	0.42190217
86	EPHB2	0.39324402
87	PRKCA	0.38986100
88	CAMK2G	0.38463887
89	MKNK1	0.38327955
90	MAP2K4	0.37149598
91	SGK3	0.35932878
92	TYRO3	0.34249892
93	MAP2K1	0.34121616
94	ROCK1	0.33885421
95	TRIM28	0.33822993
96	CCNB1	0.33338621
97	RPS6KA6	0.33131903
98	CSNK1A1L	0.32527304
99	TXK	0.32499136
100	PRKCB	0.30073740

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.26884667
2	Glutamatergic synapse_Homo sapiens_hsa04724	2.61452142
3	Morphine addiction_Homo sapiens_hsa05032	2.49981420
4	Circadian entrainment_Homo sapiens_hsa04713	2.41744798
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.34649870
6	GABAergic synapse_Homo sapiens_hsa04727	2.34094553
7	Phototransduction_Homo sapiens_hsa04744	2.33329717
8	Taste transduction_Homo sapiens_hsa04742	2.25342222
9	Insulin secretion_Homo sapiens_hsa04911	2.23564255
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.20484205
11	Amphetamine addiction_Homo sapiens_hsa05031	2.05188880
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.00825144
13	Salivary secretion_Homo sapiens_hsa04970	1.98405640
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.97736188
15	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.85946089
16	Cocaine addiction_Homo sapiens_hsa05030	1.83971956
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81442417
18	Dopaminergic synapse_Homo sapiens_hsa04728	1.79342390
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.63613192
20	Butanoate metabolism_Homo sapiens_hsa00650	1.62814511
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.62353403
22	Serotonergic synapse_Homo sapiens_hsa04726	1.61567674
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.55587925
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.52525055
25	Olfactory transduction_Homo sapiens_hsa04740	1.48980619
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.40853022
27	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38564311
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37953993
29	Cholinergic synapse_Homo sapiens_hsa04725	1.36865160
30	Renin secretion_Homo sapiens_hsa04924	1.35274293
31	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.33264719
32	Gastric acid secretion_Homo sapiens_hsa04971	1.31403726
33	Long-term depression_Homo sapiens_hsa04730	1.29903458
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23934879
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.22997160
36	cAMP signaling pathway_Homo sapiens_hsa04024	1.20947941
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17248205
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.14063293
39	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.13224286
40	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.12435811
41	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08470100
42	ABC transporters_Homo sapiens_hsa02010	1.06328683
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04331992
44	Long-term potentiation_Homo sapiens_hsa04720	0.97949413
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97615681
46	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.97444309
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.96671852
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94249723
49	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.93067133
50	Propanoate metabolism_Homo sapiens_hsa00640	0.91934437
51	Histidine metabolism_Homo sapiens_hsa00340	0.89603488
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81973989
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81781908
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.80452478
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80062474
56	Caffeine metabolism_Homo sapiens_hsa00232	0.79795622
57	Axon guidance_Homo sapiens_hsa04360	0.79722943
58	Circadian rhythm_Homo sapiens_hsa04710	0.79229538
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78948089
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.77151448
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74456685
62	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73829568
63	Pancreatic secretion_Homo sapiens_hsa04972	0.72637834
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70680156
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67447839
66	Regulation of autophagy_Homo sapiens_hsa04140	0.65849297
67	Oxidative phosphorylation_Homo sapiens_hsa00190	0.61321847
68	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.61222786
69	Mineral absorption_Homo sapiens_hsa04978	0.61190143
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61000153
71	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60013851
72	Retinol metabolism_Homo sapiens_hsa00830	0.59951361
73	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.59742534
74	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.58622074
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56605640
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55634224
77	Peroxisome_Homo sapiens_hsa04146	0.54996314
78	Bile secretion_Homo sapiens_hsa04976	0.53590476
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52490112
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50875367
81	Ras signaling pathway_Homo sapiens_hsa04014	0.50789339
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48197472
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46973916
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.45136973
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44812151
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.44804125
87	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.42878232
88	Parkinsons disease_Homo sapiens_hsa05012	0.42434738
89	Alzheimers disease_Homo sapiens_hsa05010	0.41879851
90	Melanogenesis_Homo sapiens_hsa04916	0.41578667
91	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40092401
92	Basal transcription factors_Homo sapiens_hsa03022	0.39883096
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38219947
94	Gap junction_Homo sapiens_hsa04540	0.36292592
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.34828394
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34396722
97	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.31823033
98	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30295338
99	Huntingtons disease_Homo sapiens_hsa05016	0.28355733
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.27584764

KIAA1456

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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