KIAA1522

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.02252540
2bundle of His cell to Purkinje myocyte communication (GO:0086069)5.35117270
3regulation of water loss via skin (GO:0033561)5.26950581
4epithelial cell-cell adhesion (GO:0090136)4.76405774
5establishment of skin barrier (GO:0061436)4.74140854
6hemidesmosome assembly (GO:0031581)4.68338833
7multicellular organismal water homeostasis (GO:0050891)4.57278197
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.39866742
9Golgi transport vesicle coating (GO:0048200)4.27441140
10COPI coating of Golgi vesicle (GO:0048205)4.27441140
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.03293339
12proline biosynthetic process (GO:0006561)3.91442633
13establishment of apical/basal cell polarity (GO:0035089)3.87967780
14branching involved in mammary gland duct morphogenesis (GO:0060444)3.75779811
15intestinal epithelial cell development (GO:0060576)3.75232350
16semaphorin-plexin signaling pathway (GO:0071526)3.72441053
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.67630098
18water homeostasis (GO:0030104)3.66577592
19positive regulation of Cdc42 GTPase activity (GO:0043089)3.65028741
20regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.62544701
21epithelial cell differentiation involved in prostate gland development (GO:0060742)3.50062919
22activation of Rac GTPase activity (GO:0032863)3.44872543
23calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.41744379
24primary alcohol catabolic process (GO:0034310)3.41053167
25ear development (GO:0043583)3.40126050
26protein retention in ER lumen (GO:0006621)3.38990242
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.35329760
28regulation of cholesterol biosynthetic process (GO:0045540)3.28028726
29vitamin transmembrane transport (GO:0035461)3.25104250
30lung epithelium development (GO:0060428)3.23587609
31regulation of cholesterol homeostasis (GO:2000188)3.20967504
32maternal placenta development (GO:0001893)3.19981325
33positive regulation of epidermal cell differentiation (GO:0045606)3.19481530
34gap junction assembly (GO:0016264)3.17984750
35cell-cell junction maintenance (GO:0045217)3.17450099
36endothelial cell chemotaxis (GO:0035767)3.16265704
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.15928330
38cell-substrate junction assembly (GO:0007044)3.15599852
39apical protein localization (GO:0045176)3.15541297
40atrioventricular valve morphogenesis (GO:0003181)3.13194659
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12751641
42adherens junction assembly (GO:0034333)3.07881563
43axonemal dynein complex assembly (GO:0070286)3.04156659
44establishment or maintenance of monopolar cell polarity (GO:0061339)3.03701507
45establishment of monopolar cell polarity (GO:0061162)3.03701507
46proline metabolic process (GO:0006560)3.00969248
47positive regulation of keratinocyte differentiation (GO:0045618)2.97223136
48cell-substrate adherens junction assembly (GO:0007045)2.96858939
49focal adhesion assembly (GO:0048041)2.96858939
50branching involved in salivary gland morphogenesis (GO:0060445)2.92305463
51Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.91669006
52tight junction assembly (GO:0070830)2.91520660
53regulation of glucose import in response to insulin stimulus (GO:2001273)2.89839031
54NADH metabolic process (GO:0006734)2.89098661
55asymmetric protein localization (GO:0008105)2.87173490
56surfactant homeostasis (GO:0043129)2.86433700
57negative regulation of keratinocyte proliferation (GO:0010839)2.83172661
58establishment of tissue polarity (GO:0007164)2.82949977
59establishment of planar polarity (GO:0001736)2.82949977
60negative regulation of cell fate specification (GO:0009996)2.81625623
61regulation of fatty acid beta-oxidation (GO:0031998)2.80616633
62phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80537348
63establishment or maintenance of apical/basal cell polarity (GO:0035088)2.77190317
64establishment or maintenance of bipolar cell polarity (GO:0061245)2.77190317
65regulation of cardioblast differentiation (GO:0051890)2.76872817
66cell-cell junction assembly (GO:0007043)2.75959969
67regulation of establishment of planar polarity (GO:0090175)2.75850314
68regulation of cholesterol metabolic process (GO:0090181)2.75797838
69negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.71956236
70negative regulation of cell size (GO:0045792)2.71824423
71ethanol metabolic process (GO:0006067)2.70097293
72polarized epithelial cell differentiation (GO:0030859)2.68955489
73diterpenoid biosynthetic process (GO:0016102)2.65569233
74GDP-mannose metabolic process (GO:0019673)2.63338041
75negative regulation of fatty acid transport (GO:2000192)2.63203808
76regulation of keratinocyte differentiation (GO:0045616)2.62945566
77glucose 6-phosphate metabolic process (GO:0051156)2.61008864
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60754095
79embryonic eye morphogenesis (GO:0048048)2.60540520
80peptidyl-tyrosine autophosphorylation (GO:0038083)2.60176874
81keratinization (GO:0031424)2.58853210
82cell junction maintenance (GO:0034331)2.56004750
83keratinocyte proliferation (GO:0043616)2.53635336
84regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.51965100
85amyloid precursor protein catabolic process (GO:0042987)2.51726712
86response to food (GO:0032094)2.51148813
87mammary gland epithelial cell differentiation (GO:0060644)2.50902262
88urea cycle (GO:0000050)2.49797547
89trophectodermal cell differentiation (GO:0001829)2.47851978
90positive regulation of fatty acid beta-oxidation (GO:0032000)2.47454109
91establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.46903872
92glutamine family amino acid biosynthetic process (GO:0009084)2.45935102
93motile cilium assembly (GO:0044458)2.45567077
94O-glycan processing (GO:0016266)2.45476348
95glucose catabolic process (GO:0006007)2.44510970
96regulation of endothelial cell chemotaxis (GO:2001026)2.43986055
97regulation of apoptotic process involved in morphogenesis (GO:1902337)2.43011214
98positive regulation of epidermis development (GO:0045684)2.42821884
99regulation of viral release from host cell (GO:1902186)2.42427945
100intestinal absorption (GO:0050892)2.41192462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.21591988
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45679770
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.41948700
4ZNF263_19887448_ChIP-Seq_K562_Human3.33547211
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03638222
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.01620590
7* RACK7_27058665_Chip-Seq_MCF-7_Human2.93256630
8* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.71658084
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62341852
10* LXR_22292898_ChIP-Seq_THP-1_Human2.40321319
11* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.20647193
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.19342550
13RUNX1_27514584_Chip-Seq_MCF-7_Human2.19010990
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08527362
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01708729
16* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.98066100
17CDX2_20551321_ChIP-Seq_CACO-2_Human1.95942401
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.92732134
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88573298
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84948797
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.80297068
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77906545
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77690687
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76145022
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75034839
26CLOCK_20551151_ChIP-Seq_293T_Human1.72052517
27CREB1_26743006_Chip-Seq_LNCaP_Human1.67793425
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.66104314
29GATA6_25053715_ChIP-Seq_YYC3_Human1.64589270
30CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63626171
31P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62586396
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62011397
33ATF3_27146783_Chip-Seq_COLON_Human1.61745529
34* KDM2B_26808549_Chip-Seq_K562_Human1.61067381
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60735242
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58706318
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57500226
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54862746
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52649822
40* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51784292
41SMC4_20622854_ChIP-Seq_HELA_Human1.51062088
42* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.46470001
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46154211
44* P68_20966046_ChIP-Seq_HELA_Human1.45554391
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44019257
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43824212
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41859041
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.40772272
49TCF7_22412390_ChIP-Seq_EML_Mouse1.40372258
50* KLF5_25053715_ChIP-Seq_YYC3_Human1.39581773
51* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38920859
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33872000
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33640127
54VDR_21846776_ChIP-Seq_THP-1_Human1.31978489
55AR_21909140_ChIP-Seq_LNCAP_Human1.31118812
56CTCF_27219007_Chip-Seq_Bcells_Human1.30618972
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30457066
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.30011566
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29742650
60* SOX2_20726797_ChIP-Seq_SW620_Human1.29475069
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28129940
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27532004
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.26443425
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.26105183
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23766837
66* TP63_22573176_ChIP-Seq_HFKS_Human1.22952140
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22574076
68KDM2B_26808549_Chip-Seq_DND41_Human1.22519192
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22039855
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22039855
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21969303
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18447272
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17429760
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16544671
75* CHD1_26751641_Chip-Seq_LNCaP_Human1.15621075
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13849993
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12894746
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12804935
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11705516
80* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10193019
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09282078
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07379603
83MYC_22102868_ChIP-Seq_BL_Human1.06217186
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04961527
85GATA4_25053715_ChIP-Seq_YYC3_Human1.03898077
86FOXO3_23340844_ChIP-Seq_DLD1_Human1.03668010
87TP53_22127205_ChIP-Seq_IMR90_Human1.02690327
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.01893618
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01339290
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00335394
91NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00314607
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98868866
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96659834
94ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96167905
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96075555
96DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94746191
97NCOR1_26117541_ChIP-Seq_K562_Human0.94364092
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.94233515
99* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92116927
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.90988524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.96014861
2MP0002796_impaired_skin_barrier4.19092576
3MP0000566_synostosis4.07411757
4MP0003705_abnormal_hypodermis_morpholog3.73661439
5MP0004264_abnormal_extraembryonic_tissu3.66431598
6MP0000579_abnormal_nail_morphology2.87388605
7MP0005501_abnormal_skin_physiology2.76702396
8MP0002098_abnormal_vibrissa_morphology2.60487400
9MP0005409_darkened_coat_color2.55484720
10MP0003453_abnormal_keratinocyte_physiol2.41734740
11MP0005076_abnormal_cell_differentiation2.38655632
12MP0000537_abnormal_urethra_morphology2.38037304
13MP0010678_abnormal_skin_adnexa2.36573137
14MP0000678_abnormal_parathyroid_gland2.36336460
15MP0004858_abnormal_nervous_system2.16041039
16MP0001849_ear_inflammation2.14104013
17MP0003941_abnormal_skin_development2.08328814
18MP0009780_abnormal_chondrocyte_physiolo2.02979346
19MP0003566_abnormal_cell_adhesion2.02335527
20MP0004782_abnormal_surfactant_physiolog1.99765429
21MP0000467_abnormal_esophagus_morphology1.99376413
22MP0000383_abnormal_hair_follicle1.97783577
23MP0010030_abnormal_orbit_morphology1.92066472
24MP0002249_abnormal_larynx_morphology1.87467289
25MP0001216_abnormal_epidermal_layer1.85369120
26MP0009379_abnormal_foot_pigmentation1.77728214
27MP0005360_urolithiasis1.71727788
28MP0010352_gastrointestinal_tract_polyps1.69196833
29MP0002060_abnormal_skin_morphology1.64069171
30MP0000377_abnormal_hair_follicle1.61718355
31MP0001666_abnormal_nutrient_absorption1.59674344
32MP0000762_abnormal_tongue_morphology1.54258431
33MP0010771_integument_phenotype1.45442529
34MP0005275_abnormal_skin_tensile1.45092515
35MP0000462_abnormal_digestive_system1.41212394
36MP0004185_abnormal_adipocyte_glucose1.40679854
37MP0004019_abnormal_vitamin_homeostasis1.39425384
38MP0005083_abnormal_biliary_tract1.36523185
39MP0005451_abnormal_body_composition1.33326931
40MP0000627_abnormal_mammary_gland1.26643223
41MP0005257_abnormal_intraocular_pressure1.19644655
42MP0009840_abnormal_foam_cell1.14289640
43MP0008875_abnormal_xenobiotic_pharmacok1.14108931
44MP0001346_abnormal_lacrimal_gland1.12715235
45MP0004381_abnormal_hair_follicle1.11879792
46MP0001664_abnormal_digestion1.09651478
47MP0004272_abnormal_basement_membrane1.09196991
48MP0005365_abnormal_bile_salt1.08765688
49MP0001881_abnormal_mammary_gland1.07945507
50MP0009931_abnormal_skin_appearance1.07110340
51MP0002089_abnormal_postnatal_growth/wei1.05952805
52MP0005666_abnormal_adipose_tissue1.05621983
53MP0005023_abnormal_wound_healing1.03993473
54MP0001765_abnormal_ion_homeostasis1.03860670
55MP0002896_abnormal_bone_mineralization0.99816763
56MP0000534_abnormal_ureter_morphology0.99674849
57MP0003123_paternal_imprinting0.96338258
58MP0000477_abnormal_intestine_morphology0.95658791
59MP0002877_abnormal_melanocyte_morpholog0.95274379
60MP0002254_reproductive_system_inflammat0.95187008
61MP0004947_skin_inflammation0.94295700
62MP0001873_stomach_inflammation0.92887552
63MP0001188_hyperpigmentation0.89239356
64MP0009053_abnormal_anal_canal0.87562359
65MP0003942_abnormal_urinary_system0.86298132
66MP0003191_abnormal_cellular_cholesterol0.85603426
67MP0004043_abnormal_pH_regulation0.85133663
68MP0005377_hearing/vestibular/ear_phenot0.85127913
69MP0003878_abnormal_ear_physiology0.85127913
70MP0005058_abnormal_lysosome_morphology0.85092731
71MP0000538_abnormal_urinary_bladder0.82848789
72MP0003315_abnormal_perineum_morphology0.81541712
73MP0005248_abnormal_Harderian_gland0.81471838
74MP0009672_abnormal_birth_weight0.79008808
75MP0003115_abnormal_respiratory_system0.78198908
76MP0005375_adipose_tissue_phenotype0.76889835
77MP0009643_abnormal_urine_homeostasis0.75459571
78MP0009384_cardiac_valve_regurgitation0.74895018
79MP0002111_abnormal_tail_morphology0.72641578
80MP0003183_abnormal_peptide_metabolism0.72211410
81MP0000003_abnormal_adipose_tissue0.72028093
82MP0004233_abnormal_muscle_weight0.70750347
83MP0000367_abnormal_coat/_hair0.70469320
84MP0002139_abnormal_hepatobiliary_system0.70139746
85MP0000858_altered_metastatic_potential0.64589933
86MP0005670_abnormal_white_adipose0.64454619
87MP0002909_abnormal_adrenal_gland0.63434633
88MP0005085_abnormal_gallbladder_physiolo0.63156487
89MP0002086_abnormal_extraembryonic_tissu0.63107989
90MP0000490_abnormal_crypts_of0.61892408
91MP0003091_abnormal_cell_migration0.61790576
92MP0000470_abnormal_stomach_morphology0.61357827
93MP0000681_abnormal_thyroid_gland0.60870464
94MP0001348_abnormal_lacrimal_gland0.60429546
95MP0000427_abnormal_hair_cycle0.60250339
96MP0001340_abnormal_eyelid_morphology0.59600276
97MP0002085_abnormal_embryonic_tissue0.59181289
98MP0001730_embryonic_growth_arrest0.58686964
99MP0002697_abnormal_eye_size0.58332455
100MP0008260_abnormal_autophagy0.57726576

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.69104539
2Pili torti (HP:0003777)3.79583804
3Flat acetabular roof (HP:0003180)3.64561585
4Hyperactive renin-angiotensin system (HP:0000841)3.39906024
5Chronic bronchitis (HP:0004469)3.09671464
6Lip pit (HP:0100267)3.04317231
7Thin bony cortex (HP:0002753)3.04247893
8Hyperacusis (HP:0010780)2.95443833
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.95089648
10Broad face (HP:0000283)2.93869387
11Abnormal hair laboratory examination (HP:0003328)2.90857733
12Abnormality of the distal phalanges of the toes (HP:0010182)2.90273630
13Abnormality of nail color (HP:0100643)2.81156816
14Pterygium (HP:0001059)2.76500905
15Advanced eruption of teeth (HP:0006288)2.69255791
16Septate vagina (HP:0001153)2.65188206
17Distal lower limb muscle weakness (HP:0009053)2.61747605
18Milia (HP:0001056)2.56979677
19Alopecia of scalp (HP:0002293)2.53420644
20Fragile nails (HP:0001808)2.52203840
21Cervical subluxation (HP:0003308)2.51177992
22Short nail (HP:0001799)2.49088701
23Malnutrition (HP:0004395)2.47263247
24Hemorrhage of the eye (HP:0011885)2.43696476
25Abnormality of the salivary glands (HP:0010286)2.43122356
26Plantar hyperkeratosis (HP:0007556)2.40742457
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.40183303
28Abnormality of permanent molar morphology (HP:0011071)2.38759306
29Abnormality of the dental root (HP:0006486)2.38759306
30Taurodontia (HP:0000679)2.38759306
31Germ cell neoplasia (HP:0100728)2.38574789
32Obstructive sleep apnea (HP:0002870)2.37935288
33Bronchomalacia (HP:0002780)2.36393383
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.34889309
35Ulnar bowing (HP:0003031)2.34636462
36Distal upper limb amyotrophy (HP:0007149)2.32056960
37Upper limb amyotrophy (HP:0009129)2.32056960
38Hypoplasia of dental enamel (HP:0006297)2.26932174
39Curly hair (HP:0002212)2.25217336
40Nasal polyposis (HP:0100582)2.24280985
41Abdominal distention (HP:0003270)2.22069893
42Hyperparathyroidism (HP:0000843)2.19831875
43Popliteal pterygium (HP:0009756)2.18987032
44Abnormal respiratory motile cilium physiology (HP:0012261)2.18919375
45Abnormality of molar morphology (HP:0011070)2.18537349
46Abnormality of molar (HP:0011077)2.18537349
47Hypotrichosis (HP:0001006)2.17676444
48Asymmetry of the thorax (HP:0001555)2.15363876
49Spinal cord compression (HP:0002176)2.15066105
50Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13978452
51Onycholysis (HP:0001806)2.12144805
52Woolly hair (HP:0002224)2.11765561
53Abnormality of the gastric mucosa (HP:0004295)2.10728425
54Mildly elevated creatine phosphokinase (HP:0008180)2.09707953
55Focal segmental glomerulosclerosis (HP:0000097)2.08354582
56Abnormal respiratory motile cilium morphology (HP:0005938)2.08010754
57Abnormal respiratory epithelium morphology (HP:0012253)2.08010754
58Acanthosis nigricans (HP:0000956)2.06634714
59Ankyloglossia (HP:0010296)2.06560203
60Sparse lateral eyebrow (HP:0005338)2.03714445
61Atrophic scars (HP:0001075)2.03669495
62Abnormality of the dental pulp (HP:0006479)2.02793866
63Rhinitis (HP:0012384)2.02126448
64Amelogenesis imperfecta (HP:0000705)2.00633787
65Distal lower limb amyotrophy (HP:0008944)1.97069034
66Selective tooth agenesis (HP:0001592)1.96730304
67Abnormality of carpal bone ossification (HP:0006257)1.95372488
68Nail dystrophy (HP:0008404)1.94934670
69Fragile skin (HP:0001030)1.94100158
70Atelectasis (HP:0100750)1.93168489
71Abnormal ciliary motility (HP:0012262)1.91822322
72Palmoplantar hyperkeratosis (HP:0000972)1.91779463
73Abnormality of the nasal mucosa (HP:0000433)1.91427474
74Natal tooth (HP:0000695)1.91052999
75Glomerulosclerosis (HP:0000096)1.87458736
76Ridged nail (HP:0001807)1.87007277
77Shallow orbits (HP:0000586)1.86845268
78Renal salt wasting (HP:0000127)1.86250616
79Nasolacrimal duct obstruction (HP:0000579)1.85764379
80J-shaped sella turcica (HP:0002680)1.85548462
81Stridor (HP:0010307)1.84683923
82Aplasia involving bones of the upper limbs (HP:0009823)1.83872307
83Aplasia of the phalanges of the hand (HP:0009802)1.83872307
84Aplasia involving bones of the extremities (HP:0009825)1.83872307
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.82016615
86Absent/shortened dynein arms (HP:0200106)1.82016615
87Abnormal ossification of hand bones (HP:0005921)1.80513445
88Congenital ichthyosiform erythroderma (HP:0007431)1.79086701
89Neonatal death (HP:0003811)1.75253977
90Hyperphosphatemia (HP:0002905)1.74153270
91Thick nail (HP:0001805)1.73260003
92Palmar hyperkeratosis (HP:0010765)1.70427830
93Partial duplication of thumb phalanx (HP:0009944)1.70055831
94Trismus (HP:0000211)1.69688839
95Flattened epiphyses (HP:0003071)1.69185511
96Progressive sensorineural hearing impairment (HP:0000408)1.67710985
97Long palpebral fissure (HP:0000637)1.66408405
98Abnormal blistering of the skin (HP:0008066)1.65927062
99Hand muscle atrophy (HP:0009130)1.65704047
100Abnormality of the lacrimal duct (HP:0011481)1.64581559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.72646372
2TRIB34.84577716
3MST1R4.47548684
4SIK14.10802557
5SMG12.97134994
6RIPK12.74100331
7EEF2K2.53067128
8ICK2.32627430
9MET2.27486757
10PKN22.20904855
11MAPK152.11477759
12IRAK32.08799409
13ERN12.04023774
14LMTK21.93594204
15MAPKAPK31.88174841
16PAK41.71168583
17FGFR41.65170144
18RPS6KB21.63629889
19PTK61.54372008
20CDK121.50713609
21TESK11.50411737
22PTK21.47613960
23LATS21.31859757
24MAP3K21.29602962
25PRKD31.26909560
26PDGFRA1.12316515
27EPHB11.10998608
28MTOR1.09231172
29FER1.07621833
30MAP3K101.04064703
31EPHB21.02806938
32LATS10.97891299
33RPS6KA20.97207556
34NME20.93739603
35MAP3K30.90477742
36MAP2K20.87637114
37NEK60.86766475
38NME10.83912532
39TAOK10.82924078
40PRKG20.82734318
41PRPF4B0.82418269
42PRKD20.82164296
43NTRK10.81978433
44PRKCI0.81178336
45BMX0.79358886
46MAP3K90.78655025
47LRRK20.77621076
48CDC42BPA0.71924570
49CDK70.69708978
50STK380.69399105
51SCYL20.69011566
52MARK20.64412724
53ILK0.64080206
54MUSK0.63341095
55DMPK0.62494807
56IRAK20.61453560
57PDPK10.61144863
58CAMK1D0.60829468
59TESK20.60605292
60MAP3K60.53477068
61MAP3K10.52797493
62ERBB20.51901955
63AKT30.51804875
64RET0.51128861
65HIPK20.50370895
66ARAF0.49850236
67CHUK0.49526276
68STK390.49028059
69PIK3CA0.48682813
70MAP3K120.48370744
71TTN0.43183451
72RPS6KC10.43164674
73RPS6KL10.43164674
74MST40.42931766
75TTK0.41357078
76DDR20.38908648
77STK240.38563612
78CAMK1G0.36820195
79EIF2AK10.35160852
80MAPKAPK20.34788044
81MAP2K10.34312450
82AKT20.33155346
83KSR20.33007518
84CDK80.31824628
85FGFR10.30531880
86SIK30.30230446
87CAMK2G0.30028639
88MAP3K80.29994847
89RPS6KA60.27995450
90PDGFRB0.27884146
91PBK0.27878210
92TAOK20.27268214
93CDK90.25113338
94MELK0.23257672
95MYLK0.23088484
96WNK40.22391695
97MAP3K70.22389915
98FGFR30.22180240
99MAPK80.21232364
100RPS6KB10.20988469

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.33886649
2Phenylalanine metabolism_Homo sapiens_hsa003602.48729928
3Fructose and mannose metabolism_Homo sapiens_hsa000512.38361972
4Histidine metabolism_Homo sapiens_hsa003402.29916756
5Vitamin digestion and absorption_Homo sapiens_hsa049772.08799900
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83104551
7Notch signaling pathway_Homo sapiens_hsa043301.79284493
8Thyroid cancer_Homo sapiens_hsa052161.78013889
9Arginine biosynthesis_Homo sapiens_hsa002201.69412763
10Tight junction_Homo sapiens_hsa045301.67518878
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66878578
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52682590
13Galactose metabolism_Homo sapiens_hsa000521.51690889
14Fat digestion and absorption_Homo sapiens_hsa049751.46379239
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45723754
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44047243
17Tyrosine metabolism_Homo sapiens_hsa003501.40785881
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39184721
19Adherens junction_Homo sapiens_hsa045201.38820417
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.38228017
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36950707
22Bladder cancer_Homo sapiens_hsa052191.36050767
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35274470
24Bile secretion_Homo sapiens_hsa049761.35008066
25Pentose phosphate pathway_Homo sapiens_hsa000301.30663940
26Chemical carcinogenesis_Homo sapiens_hsa052041.26966553
27Endometrial cancer_Homo sapiens_hsa052131.23671092
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22667947
29Sphingolipid metabolism_Homo sapiens_hsa006001.22583609
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19671577
31Biosynthesis of amino acids_Homo sapiens_hsa012301.18777132
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18177755
33Fatty acid biosynthesis_Homo sapiens_hsa000611.17798185
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12950955
35Glutathione metabolism_Homo sapiens_hsa004801.10023990
36Renin-angiotensin system_Homo sapiens_hsa046141.09527217
37Arginine and proline metabolism_Homo sapiens_hsa003301.08490614
38Chronic myeloid leukemia_Homo sapiens_hsa052201.07768090
39Starch and sucrose metabolism_Homo sapiens_hsa005001.06662989
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.06088108
41AMPK signaling pathway_Homo sapiens_hsa041521.05732776
42Hepatitis C_Homo sapiens_hsa051601.04631956
43Other glycan degradation_Homo sapiens_hsa005111.04487736
44Sulfur relay system_Homo sapiens_hsa041221.04289263
45ECM-receptor interaction_Homo sapiens_hsa045121.03979073
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02869216
47Insulin signaling pathway_Homo sapiens_hsa049101.02806658
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02274210
49Mineral absorption_Homo sapiens_hsa049781.01844127
50Protein digestion and absorption_Homo sapiens_hsa049740.98867874
51VEGF signaling pathway_Homo sapiens_hsa043700.98388088
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96447343
53Insulin resistance_Homo sapiens_hsa049310.96250821
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96050029
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91383802
56Retinol metabolism_Homo sapiens_hsa008300.90401661
57ErbB signaling pathway_Homo sapiens_hsa040120.88568437
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.87225882
59Acute myeloid leukemia_Homo sapiens_hsa052210.87059847
60Hippo signaling pathway_Homo sapiens_hsa043900.86871921
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.83894324
62Choline metabolism in cancer_Homo sapiens_hsa052310.83279540
63Vibrio cholerae infection_Homo sapiens_hsa051100.82044920
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81329374
65Axon guidance_Homo sapiens_hsa043600.81269667
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.77912233
67Small cell lung cancer_Homo sapiens_hsa052220.77532697
68Vitamin B6 metabolism_Homo sapiens_hsa007500.77385917
69Proteoglycans in cancer_Homo sapiens_hsa052050.76909067
70Renal cell carcinoma_Homo sapiens_hsa052110.76090516
71mTOR signaling pathway_Homo sapiens_hsa041500.75882818
72PPAR signaling pathway_Homo sapiens_hsa033200.75792147
73Sulfur metabolism_Homo sapiens_hsa009200.75353424
74Amoebiasis_Homo sapiens_hsa051460.74746994
75Prostate cancer_Homo sapiens_hsa052150.74679569
76Focal adhesion_Homo sapiens_hsa045100.74293369
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72861234
78Estrogen signaling pathway_Homo sapiens_hsa049150.69588132
79Lysine degradation_Homo sapiens_hsa003100.67076815
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66154185
81Basal cell carcinoma_Homo sapiens_hsa052170.66114998
82N-Glycan biosynthesis_Homo sapiens_hsa005100.65749732
83Inositol phosphate metabolism_Homo sapiens_hsa005620.65657873
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65569261
85Carbon metabolism_Homo sapiens_hsa012000.64996814
86Pancreatic cancer_Homo sapiens_hsa052120.63076320
87beta-Alanine metabolism_Homo sapiens_hsa004100.62813359
88Non-small cell lung cancer_Homo sapiens_hsa052230.62608760
89Thyroid hormone synthesis_Homo sapiens_hsa049180.62435830
90Pancreatic secretion_Homo sapiens_hsa049720.62374728
91Prion diseases_Homo sapiens_hsa050200.61715593
92Glucagon signaling pathway_Homo sapiens_hsa049220.60036155
93Pyruvate metabolism_Homo sapiens_hsa006200.59802611
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59281897
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59149187
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58730023
97MicroRNAs in cancer_Homo sapiens_hsa052060.56254600
98Melanogenesis_Homo sapiens_hsa049160.54929154
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.54782476
100Fatty acid degradation_Homo sapiens_hsa000710.54148569

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