ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitotic sister chromatid segregation (GO:0000070)	6.35716091
2	sister chromatid segregation (GO:0000819)	6.19115662
3	protein localization to kinetochore (GO:0034501)	6.13472982
4	mitotic metaphase plate congression (GO:0007080)	5.98227345
5	mitotic chromosome condensation (GO:0007076)	5.90329938
6	protein localization to chromosome, centromeric region (GO:0071459)	5.77190536
7	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	5.69648916
8	kinetochore organization (GO:0051383)	5.53261485
9	CENP-A containing nucleosome assembly (GO:0034080)	5.48157962
10	metaphase plate congression (GO:0051310)	5.47105616
11	chromatin remodeling at centromere (GO:0031055)	5.40587689
12	nuclear pore complex assembly (GO:0051292)	5.36940327
13	DNA strand elongation involved in DNA replication (GO:0006271)	5.17274064
14	DNA unwinding involved in DNA replication (GO:0006268)	5.11976542
15	DNA strand elongation (GO:0022616)	4.96869326
16	mitotic sister chromatid cohesion (GO:0007064)	4.91168902
17	nuclear pore organization (GO:0006999)	4.84185861
18	telomere maintenance via semi-conservative replication (GO:0032201)	4.78660827
19	establishment of chromosome localization (GO:0051303)	4.73340800
20	kinetochore assembly (GO:0051382)	4.58489651
21	histone exchange (GO:0043486)	4.58064013
22	DNA replication checkpoint (GO:0000076)	4.57705795
23	DNA ligation (GO:0006266)	4.53738525
24	regulation of mitotic spindle organization (GO:0060236)	4.48556261
25	DNA topological change (GO:0006265)	4.47918866
26	regulation of spindle organization (GO:0090224)	4.47454908
27	regulation of centriole replication (GO:0046599)	4.46161324
28	spindle checkpoint (GO:0031577)	4.45440270
29	DNA replication-independent nucleosome organization (GO:0034724)	4.42874624
30	DNA replication-independent nucleosome assembly (GO:0006336)	4.42874624
31	meiotic chromosome segregation (GO:0045132)	4.37523986
32	mitotic recombination (GO:0006312)	4.37047296
33	regulation of chromosome segregation (GO:0051983)	4.33184732
34	establishment of integrated proviral latency (GO:0075713)	4.25960287
35	telomere maintenance via recombination (GO:0000722)	4.23082625
36	mitotic nuclear envelope disassembly (GO:0007077)	4.22215079
37	chromosome segregation (GO:0007059)	4.20362679
38	negative regulation of chromosome segregation (GO:0051985)	4.19974457
39	mitotic spindle checkpoint (GO:0071174)	4.15511065
40	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	4.12104674
41	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	4.12104674
42	negative regulation of mitotic sister chromatid segregation (GO:0033048)	4.12104674
43	negative regulation of mitotic sister chromatid separation (GO:2000816)	4.12104674
44	negative regulation of sister chromatid segregation (GO:0033046)	4.12104674
45	regulation of mitotic metaphase/anaphase transition (GO:0030071)	4.03978973
46	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	4.03978973
47	pore complex assembly (GO:0046931)	4.00503532
48	chromosome condensation (GO:0030261)	3.99223123
49	regulation of DNA endoreduplication (GO:0032875)	3.98877272
50	mitotic spindle assembly checkpoint (GO:0007094)	3.97413245
51	spindle assembly checkpoint (GO:0071173)	3.96997489
52	protein localization to chromosome (GO:0034502)	3.96782123
53	regulation of mitotic sister chromatid separation (GO:0010965)	3.95914945
54	regulation of mitotic sister chromatid segregation (GO:0033047)	3.95914945
55	regulation of sister chromatid segregation (GO:0033045)	3.95914945
56	positive regulation of chromosome segregation (GO:0051984)	3.95717972
57	DNA replication initiation (GO:0006270)	3.94688050
58	membrane disassembly (GO:0030397)	3.90757861
59	nuclear envelope disassembly (GO:0051081)	3.90757861
60	microtubule depolymerization (GO:0007019)	3.90252418
61	regulation of centrosome cycle (GO:0046605)	3.89631666
62	attachment of spindle microtubules to kinetochore (GO:0008608)	3.86832293
63	non-recombinational repair (GO:0000726)	3.77899527
64	double-strand break repair via nonhomologous end joining (GO:0006303)	3.77899527
65	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.67446597
66	mitotic G2/M transition checkpoint (GO:0044818)	3.64925917
67	DNA replication-dependent nucleosome organization (GO:0034723)	3.60631179
68	DNA replication-dependent nucleosome assembly (GO:0006335)	3.60631179
69	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.54549283
70	chromatin assembly or disassembly (GO:0006333)	3.53374137
71	regulation of sister chromatid cohesion (GO:0007063)	3.53018516
72	ATP-dependent chromatin remodeling (GO:0043044)	3.51778779
73	DNA packaging (GO:0006323)	3.51059927
74	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.49826538
75	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.49514102
76	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.49514102
77	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.49514102
78	protein K6-linked ubiquitination (GO:0085020)	3.48242665
79	regulation of centrosome duplication (GO:0010824)	3.43353342
80	replication fork processing (GO:0031297)	3.42154201
81	telomere maintenance via telomere lengthening (GO:0010833)	3.42007277
82	IMP biosynthetic process (GO:0006188)	3.34181672
83	resolution of meiotic recombination intermediates (GO:0000712)	3.31581715
84	mitotic cell cycle (GO:0000278)	3.30202492
85	negative regulation of mitosis (GO:0045839)	3.30091681
86	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.29722038
87	purine nucleobase biosynthetic process (GO:0009113)	3.28642719
88	DNA double-strand break processing (GO:0000729)	3.28171717
89	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.27652106
90	histone-serine phosphorylation (GO:0035404)	3.25676495
91	mitotic spindle organization (GO:0007052)	3.24252573
92	DNA duplex unwinding (GO:0032508)	3.24193498
93	heterochromatin organization (GO:0070828)	3.23686574
94	DNA conformation change (GO:0071103)	3.22852314
95	spindle assembly involved in mitosis (GO:0090307)	3.22840300
96	DNA geometric change (GO:0032392)	3.18801952
97	establishment of viral latency (GO:0019043)	3.18305147
98	nucleobase biosynthetic process (GO:0046112)	3.12429852
99	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.11696724
100	chromosome organization (GO:0051276)	3.06153778

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	7.52796449
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	5.54772760
3	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.73427115
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.81372565
5	AR_21909140_ChIP-Seq_LNCAP_Human	3.73588572
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.53562790
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.84223043
8	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.72566574
9	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.68938140
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.67856898
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.55069097
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.51855119
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51609919
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.46785363
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.38683063
16	* GABP_17652178_ChIP-ChIP_JURKAT_Human	2.36884292
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.35908261
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.33708592
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.33592812
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.27840821
21	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.16924510
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.16427871
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.05818433
24	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.02225996
25	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.01325965
26	E2F7_22180533_ChIP-Seq_HELA_Human	10.2770462
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.96673332
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.94420120
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.81952630
30	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.78178506
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.77654642
32	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.75948196
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.72725300
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.72208847
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.66775864
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66597452
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.65641767
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.61087038
39	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.60658537
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.48626266
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.47019638
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.46726408
43	* GABP_19822575_ChIP-Seq_HepG2_Human	1.40406328
44	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.39571643
45	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.35674263
46	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.34743461
47	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.30289726
48	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.28547397
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.25600329
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.25143417
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.23463981
52	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.22482268
53	EWS_26573619_Chip-Seq_HEK293_Human	1.20794533
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.20701559
55	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.18592461
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17521955
57	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.15181595
58	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12122290
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.07788471
60	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.05216392
61	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.02931122
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00279759
63	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.99971363
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.97985996
65	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.96746415
66	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96298590
67	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.95914915
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.95905207
69	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.94932861
70	FUS_26573619_Chip-Seq_HEK293_Human	0.90651984
71	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.86384784
72	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.85926114
73	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.84369385
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.83741670
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.81872651
76	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.81344006
77	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.80340966
78	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.79310451
79	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.78756399
80	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.77796121
81	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.77672096
82	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.77287899
83	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.76392389
84	TFEB_21752829_ChIP-Seq_HELA_Human	0.75556371
85	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.75168120
86	CIITA_25753668_ChIP-Seq_RAJI_Human	0.74076511
87	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.72928105
88	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.72178309
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.71966672
90	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.70801924
91	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.67175344
92	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.67137601
93	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.67046966
94	CHD1_26751641_Chip-Seq_LNCaP_Human	0.67031493
95	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.66396744
96	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.64946141
97	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.64593212
98	IRF1_19129219_ChIP-ChIP_H3396_Human	0.64481376
99	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.63717824
100	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.63164740

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	5.96574126
2	MP0003693_abnormal_embryo_hatching	5.05979270
3	MP0003111_abnormal_nucleus_morphology	4.90832997
4	MP0008057_abnormal_DNA_replication	4.72309782
5	MP0004957_abnormal_blastocyst_morpholog	4.31283377
6	MP0003077_abnormal_cell_cycle	4.15298300
7	MP0008058_abnormal_DNA_repair	3.89911860
8	MP0008932_abnormal_embryonic_tissue	3.25226186
9	MP0008007_abnormal_cellular_replicative	2.90969914
10	MP0009697_abnormal_copulation	2.60384477
11	MP0003890_abnormal_embryonic-extraembry	2.29390006
12	MP0003718_maternal_effect	2.19110795
13	MP0010307_abnormal_tumor_latency	2.11287666
14	MP0000350_abnormal_cell_proliferation	2.02117004
15	MP0001730_embryonic_growth_arrest	2.00787103
16	MP0010352_gastrointestinal_tract_polyps	1.98763260
17	MP0003786_premature_aging	1.82271285
18	MP0006292_abnormal_olfactory_placode	1.82181032
19	MP0001672_abnormal_embryogenesis/_devel	1.79327363
20	MP0005380_embryogenesis_phenotype	1.79327363
21	MP0001697_abnormal_embryo_size	1.75191394
22	MP0001293_anophthalmia	1.70390397
23	MP0003941_abnormal_skin_development	1.66962711
24	MP0002085_abnormal_embryonic_tissue	1.58130007
25	MP0003937_abnormal_limbs/digits/tail_de	1.58122079
26	MP0002084_abnormal_developmental_patter	1.56903164
27	MP0010030_abnormal_orbit_morphology	1.53576463
28	MP0003984_embryonic_growth_retardation	1.49443240
29	MP0002080_prenatal_lethality	1.48611980
30	MP0002088_abnormal_embryonic_growth/wei	1.43714378
31	MP0002396_abnormal_hematopoietic_system	1.37645986
32	MP0002697_abnormal_eye_size	1.35392207
33	MP0004197_abnormal_fetal_growth/weight/	1.33346296
34	MP0009672_abnormal_birth_weight	1.32170930
35	MP0000313_abnormal_cell_death	1.29016834
36	MP0002877_abnormal_melanocyte_morpholog	1.28299277
37	MP0003806_abnormal_nucleotide_metabolis	1.23906864
38	MP0008877_abnormal_DNA_methylation	1.23421842
39	MP0001286_abnormal_eye_development	1.22428226
40	MP0002938_white_spotting	1.18938184
41	MP0002210_abnormal_sex_determination	1.16199846
42	MP0002086_abnormal_extraembryonic_tissu	1.13986775
43	MP0002234_abnormal_pharynx_morphology	1.09461420
44	MP0001929_abnormal_gametogenesis	1.07426182
45	MP0002111_abnormal_tail_morphology	1.07322022
46	MP0003705_abnormal_hypodermis_morpholog	1.05329702
47	MP0003567_abnormal_fetal_cardiomyocyte	1.01939732
48	MP0003950_abnormal_plasma_membrane	0.99948139
49	MP0000428_abnormal_craniofacial_morphol	0.97390118
50	MP0002233_abnormal_nose_morphology	0.97166171
51	MP0002019_abnormal_tumor_incidence	0.96686608
52	MP0003136_yellow_coat_color	0.96372550
53	MP0000358_abnormal_cell_content/	0.96002574
54	MP0003119_abnormal_digestive_system	0.95485408
55	MP0002009_preneoplasia	0.95265975
56	MP0001145_abnormal_male_reproductive	0.94207006
57	MP0000537_abnormal_urethra_morphology	0.93083851
58	MP0006035_abnormal_mitochondrial_morpho	0.91521301
59	MP0005623_abnormal_meninges_morphology	0.91037412
60	MP0003755_abnormal_palate_morphology	0.90923988
61	MP0002092_abnormal_eye_morphology	0.90249146
62	MP0003315_abnormal_perineum_morphology	0.89645164
63	MP0002160_abnormal_reproductive_system	0.89338423
64	MP0009703_decreased_birth_body	0.87344405
65	MP0005076_abnormal_cell_differentiation	0.86567594
66	MP0000653_abnormal_sex_gland	0.85287557
67	MP0008789_abnormal_olfactory_epithelium	0.83054618
68	MP0009053_abnormal_anal_canal	0.82497038
69	MP0000372_irregular_coat_pigmentation	0.80351927
70	MP0003385_abnormal_body_wall	0.80210593
71	MP0000490_abnormal_crypts_of	0.78947249
72	MP0003935_abnormal_craniofacial_develop	0.75804693
73	MP0001119_abnormal_female_reproductive	0.74721101
74	MP0004185_abnormal_adipocyte_glucose	0.74185413
75	MP0003861_abnormal_nervous_system	0.74131566
76	MP0001529_abnormal_vocalization	0.72889397
77	MP0000647_abnormal_sebaceous_gland	0.72856099
78	MP0005395_other_phenotype	0.71722971
79	MP0005384_cellular_phenotype	0.71478802
80	MP0006072_abnormal_retinal_apoptosis	0.69243485
81	MP0000432_abnormal_head_morphology	0.68145879
82	MP0005621_abnormal_cell_physiology	0.68092354
83	MP0003943_abnormal_hepatobiliary_system	0.67589198
84	MP0001299_abnormal_eye_distance/	0.67217892
85	MP0001346_abnormal_lacrimal_gland	0.67077855
86	MP0005499_abnormal_olfactory_system	0.64935569
87	MP0005394_taste/olfaction_phenotype	0.64935569
88	MP0000049_abnormal_middle_ear	0.64835532
89	MP0003699_abnormal_female_reproductive	0.64020779
90	MP0003121_genomic_imprinting	0.63276081
91	MP0000762_abnormal_tongue_morphology	0.60595783
92	MP0002102_abnormal_ear_morphology	0.60238833
93	MP0005391_vision/eye_phenotype	0.58975901
94	MP0002161_abnormal_fertility/fecundity	0.58199290
95	MP0003698_abnormal_male_reproductive	0.57964023
96	MP0002177_abnormal_outer_ear	0.55588543
97	MP0005171_absent_coat_pigmentation	0.55023597
98	MP0002751_abnormal_autonomic_nervous	0.55007005
99	MP0005501_abnormal_skin_physiology	0.54510112
100	MP0003566_abnormal_cell_adhesion	0.53938673

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	7.20699662
2	Chromsome breakage (HP:0040012)	6.74722760
3	Abnormality of chromosome stability (HP:0003220)	4.84658341
4	Meckel diverticulum (HP:0002245)	4.75438714
5	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.63933171
6	Abnormality of the ileum (HP:0001549)	4.56977839
7	Abnormality of the preputium (HP:0100587)	4.46771020
8	Small intestinal stenosis (HP:0012848)	4.09068592
9	Duodenal stenosis (HP:0100867)	4.09068592
10	Volvulus (HP:0002580)	3.88143343
11	Increased nuchal translucency (HP:0010880)	3.70929446
12	Nephroblastoma (Wilms tumor) (HP:0002667)	3.67388806
13	Abnormal lung lobation (HP:0002101)	3.65741728
14	Embryonal renal neoplasm (HP:0011794)	3.62424314
15	Abnormality of the duodenum (HP:0002246)	3.52050744
16	Birth length less than 3rd percentile (HP:0003561)	3.47403242
17	Abnormality of the carotid arteries (HP:0005344)	3.39437052
18	Myelodysplasia (HP:0002863)	3.27850467
19	Cortical dysplasia (HP:0002539)	3.08868739
20	Sloping forehead (HP:0000340)	2.96863735
21	Clubbing of toes (HP:0100760)	2.95271630
22	Absent radius (HP:0003974)	2.83671200
23	Triphalangeal thumb (HP:0001199)	2.74052209
24	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.73525527
25	Ectopic kidney (HP:0000086)	2.69214743
26	Abnormality of the labia minora (HP:0012880)	2.67177495
27	Aplasia involving forearm bones (HP:0009822)	2.64166150
28	Absent forearm bone (HP:0003953)	2.64166150
29	Colon cancer (HP:0003003)	2.61679528
30	Cafe-au-lait spot (HP:0000957)	2.54913589
31	Rhabdomyosarcoma (HP:0002859)	2.54273377
32	Reticulocytopenia (HP:0001896)	2.49943388
33	Ependymoma (HP:0002888)	2.41147481
34	Medulloblastoma (HP:0002885)	2.38458934
35	Abnormality of the fetal cardiovascular system (HP:0010948)	2.32643671
36	Abnormal umbilical cord blood vessels (HP:0011403)	2.32643671
37	Single umbilical artery (HP:0001195)	2.32643671
38	Arteriovenous malformation (HP:0100026)	2.30288543
39	Horseshoe kidney (HP:0000085)	2.27186480
40	Choanal atresia (HP:0000453)	2.25397448
41	Duplicated collecting system (HP:0000081)	2.24217797
42	Glioma (HP:0009733)	2.19594358
43	Embryonal neoplasm (HP:0002898)	2.16921627
44	Hypoplastic pelvis (HP:0008839)	2.15451009
45	Selective tooth agenesis (HP:0001592)	2.15156075
46	Proximal placement of thumb (HP:0009623)	2.13929183
47	Neoplasm of the colon (HP:0100273)	2.11716722
48	Short thumb (HP:0009778)	2.10387103
49	Abnormality of chromosome segregation (HP:0002916)	2.05402391
50	Deviation of the thumb (HP:0009603)	2.04558919
51	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.98914857
52	Breast hypoplasia (HP:0003187)	1.97970030
53	Absent thumb (HP:0009777)	1.94739376
54	Abnormal number of incisors (HP:0011064)	1.94665996
55	Abnormality of the umbilical cord (HP:0010881)	1.94024246
56	Multiple enchondromatosis (HP:0005701)	1.91848910
57	Abnormality of the astrocytes (HP:0100707)	1.91806852
58	Astrocytoma (HP:0009592)	1.91806852
59	Bone marrow hypocellularity (HP:0005528)	1.90562443
60	Patellar aplasia (HP:0006443)	1.89649352
61	Supernumerary spleens (HP:0009799)	1.88152112
62	Missing ribs (HP:0000921)	1.86679516
63	Abnormality of the renal collecting system (HP:0004742)	1.85798178
64	Abnormality of DNA repair (HP:0003254)	1.85194242
65	Duplication of thumb phalanx (HP:0009942)	1.82980191
66	Tracheoesophageal fistula (HP:0002575)	1.80242773
67	Microvesicular hepatic steatosis (HP:0001414)	1.77720804
68	Facial hemangioma (HP:0000329)	1.77558902
69	High pitched voice (HP:0001620)	1.76190917
70	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71422632
71	Abnormality of the septum pellucidum (HP:0007375)	1.70767077
72	Overlapping toe (HP:0001845)	1.69861337
73	Bilateral microphthalmos (HP:0007633)	1.68800889
74	Small hand (HP:0200055)	1.68612941
75	Ovarian neoplasm (HP:0100615)	1.66788281
76	Intestinal atresia (HP:0011100)	1.64313854
77	Squamous cell carcinoma (HP:0002860)	1.62874069
78	Abnormality of the pons (HP:0007361)	1.62760934
79	Facial cleft (HP:0002006)	1.62421029
80	Prominent nose (HP:0000448)	1.62185733
81	Facial asymmetry (HP:0000324)	1.62052880
82	Abnormal auditory evoked potentials (HP:0006958)	1.61801470
83	Deep philtrum (HP:0002002)	1.59633921
84	Absent septum pellucidum (HP:0001331)	1.59560355
85	Neoplasm of striated muscle (HP:0009728)	1.58599366
86	Septo-optic dysplasia (HP:0100842)	1.58434524
87	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.57224178
88	Progressive external ophthalmoplegia (HP:0000590)	1.56324680
89	Hypoplasia of the pons (HP:0012110)	1.56047718
90	Poikiloderma (HP:0001029)	1.55653991
91	Carpal bone hypoplasia (HP:0001498)	1.54270066
92	Impulsivity (HP:0100710)	1.52363486
93	Atresia of the external auditory canal (HP:0000413)	1.52282719
94	Astigmatism (HP:0000483)	1.51752843
95	Renal agenesis (HP:0000104)	1.51221959
96	Abnormality of cochlea (HP:0000375)	1.51150473
97	High anterior hairline (HP:0009890)	1.51084381
98	Oligohydramnios (HP:0001562)	1.50570790
99	Malignant gastrointestinal tract tumors (HP:0006749)	1.50469063
100	Gastrointestinal carcinoma (HP:0002672)	1.50469063

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	5.61209286
2	CDC7	4.21684600
3	TTK	4.20582780
4	NEK1	3.63021642
5	WEE1	3.44065870
6	PLK4	3.27399131
7	PBK	3.04500650
8	SRPK1	2.76787511
9	BRSK2	2.62501071
10	PLK3	2.50707731
11	NEK2	2.36762448
12	TSSK6	2.34756994
13	ZAK	2.33267293
14	PLK1	2.18338701
15	MKNK2	2.13623540
16	MKNK1	2.06197577
17	EIF2AK1	1.98063591
18	VRK2	1.87256071
19	CHEK2	1.85471857
20	BRSK1	1.76524225
21	EIF2AK3	1.68549333
22	AURKB	1.62926870
23	ATR	1.56810621
24	TRIM28	1.53752503
25	CCNB1	1.53300962
26	TAF1	1.49956988
27	VRK1	1.48273199
28	MST4	1.44573030
29	PNCK	1.30658250
30	NUAK1	1.20028507
31	CDK7	1.14508155
32	STK3	1.14115856
33	CHEK1	1.12965554
34	EIF2AK2	1.11332236
35	STK10	1.08420728
36	MELK	1.06066661
37	AURKA	0.99533823
38	BRD4	0.98498705
39	ATM	0.98092160
40	BMPR1B	0.95338790
41	ERBB4	0.94789567
42	SCYL2	0.93638914
43	STK4	0.92191563
44	LATS1	0.88944935
45	MAP3K8	0.88855779
46	BRAF	0.85360568
47	ACVR1B	0.84098776
48	CDK4	0.79679782
49	CDK8	0.78838630
50	MAP3K10	0.78783065
51	BCR	0.75989630
52	MST1R	0.72664071
53	CDK1	0.72516342
54	CDK12	0.72492817
55	ERBB3	0.71901879
56	NME2	0.68854444
57	CLK1	0.66946480
58	CDK6	0.63918341
59	WNK3	0.63852162
60	TLK1	0.63761131
61	RPS6KB2	0.62361793
62	PAK4	0.62100177
63	TNIK	0.60320438
64	CDK2	0.60008600
65	STK16	0.58424506
66	ALK	0.58153905
67	SMG1	0.57864477
68	PLK2	0.54151817
69	RPS6KA4	0.53930444
70	PASK	0.52470384
71	MET	0.51949775
72	TGFBR1	0.45505159
73	LATS2	0.42155836
74	CDK9	0.41966154
75	CSNK2A1	0.41591626
76	CSNK2A2	0.40159897
77	PRKDC	0.39479719
78	PRKCI	0.39461811
79	FGFR1	0.37902573
80	CDK18	0.37874681
81	STK38L	0.36835641
82	CDK15	0.34133979
83	PAK1	0.33583018
84	MARK3	0.33101325
85	CSNK1E	0.32101808
86	PDK2	0.31842065
87	CDK11A	0.31643966
88	CDK14	0.31550245
89	NEK9	0.31059102
90	CSNK1G1	0.30529766
91	CDK3	0.28105794
92	AKT2	0.22914428
93	DYRK3	0.21137560
94	NME1	0.20967457
95	MAPK14	0.18858647
96	CSNK1G3	0.18281555
97	MAP3K4	0.17789113
98	FLT3	0.16718661
99	CSNK1A1L	0.16363678
100	UHMK1	0.14855375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	5.21177752
2	Mismatch repair_Homo sapiens_hsa03430	4.60894892
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.81823617
4	Homologous recombination_Homo sapiens_hsa03440	3.54524221
5	Cell cycle_Homo sapiens_hsa04110	3.53830041
6	Fanconi anemia pathway_Homo sapiens_hsa03460	3.34879450
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.19758404
8	Base excision repair_Homo sapiens_hsa03410	2.99147721
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.88680673
10	Proteasome_Homo sapiens_hsa03050	2.74836680
11	Spliceosome_Homo sapiens_hsa03040	2.67186858
12	RNA transport_Homo sapiens_hsa03013	2.64533487
13	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.62856090
14	One carbon pool by folate_Homo sapiens_hsa00670	2.29546508
15	Basal transcription factors_Homo sapiens_hsa03022	1.95892974
16	RNA polymerase_Homo sapiens_hsa03020	1.91235399
17	Pyrimidine metabolism_Homo sapiens_hsa00240	1.83178332
18	RNA degradation_Homo sapiens_hsa03018	1.77243211
19	p53 signaling pathway_Homo sapiens_hsa04115	1.65450134
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.61393853
21	Oocyte meiosis_Homo sapiens_hsa04114	1.53527203
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.46665180
23	Protein export_Homo sapiens_hsa03060	1.45218925
24	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.29693908
25	Ribosome_Homo sapiens_hsa03010	1.27763084
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.27473355
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.20299700
28	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.19566695
29	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.16658386
30	Purine metabolism_Homo sapiens_hsa00230	1.15468621
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.14026984
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.08815849
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.04889497
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.03945142
35	Steroid biosynthesis_Homo sapiens_hsa00100	0.97215879
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87229896
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85242317
38	Carbon metabolism_Homo sapiens_hsa01200	0.80981821
39	Folate biosynthesis_Homo sapiens_hsa00790	0.80395231
40	Propanoate metabolism_Homo sapiens_hsa00640	0.79386855
41	Fatty acid elongation_Homo sapiens_hsa00062	0.78818870
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.77498208
43	MicroRNAs in cancer_Homo sapiens_hsa05206	0.77465519
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77229183
45	Viral carcinogenesis_Homo sapiens_hsa05203	0.73221328
46	Lysine degradation_Homo sapiens_hsa00310	0.71960301
47	Alcoholism_Homo sapiens_hsa05034	0.67899951
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.66404460
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.65764397
50	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.62365611
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.61167871
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61145933
53	Adherens junction_Homo sapiens_hsa04520	0.60450675
54	Thyroid cancer_Homo sapiens_hsa05216	0.60096262
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58928112
56	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.58796270
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.58605442
58	Glutathione metabolism_Homo sapiens_hsa00480	0.58388925
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58293747
60	Huntingtons disease_Homo sapiens_hsa05016	0.57754473
61	Small cell lung cancer_Homo sapiens_hsa05222	0.54492912
62	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53412567
63	Colorectal cancer_Homo sapiens_hsa05210	0.47192563
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.46899038
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46791475
66	HTLV-I infection_Homo sapiens_hsa05166	0.43524357
67	Parkinsons disease_Homo sapiens_hsa05012	0.42610234
68	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42011031
69	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.39688413
70	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.38683685
71	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.34650136
72	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.34041502
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.33570454
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33362831
75	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.31174210
76	Sulfur relay system_Homo sapiens_hsa04122	0.30266465
77	Metabolic pathways_Homo sapiens_hsa01100	0.29631224
78	Prostate cancer_Homo sapiens_hsa05215	0.29370952
79	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.28047936
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26614376
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.26204536
82	Oxidative phosphorylation_Homo sapiens_hsa00190	0.25870754
83	Pancreatic cancer_Homo sapiens_hsa05212	0.24137796
84	Melanoma_Homo sapiens_hsa05218	0.22895079
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.22757318
86	Bladder cancer_Homo sapiens_hsa05219	0.21596864
87	Herpes simplex infection_Homo sapiens_hsa05168	0.19143775
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.17006925
89	Pathways in cancer_Homo sapiens_hsa05200	0.15798925
90	Proteoglycans in cancer_Homo sapiens_hsa05205	0.15611001
91	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.13698277
92	Hepatitis B_Homo sapiens_hsa05161	0.10102486
93	Alzheimers disease_Homo sapiens_hsa05010	0.09694557
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.07856334
95	Tight junction_Homo sapiens_hsa04530	0.07778872
96	Olfactory transduction_Homo sapiens_hsa04740	0.07535324
97	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.07174555
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.05991304
99	Shigellosis_Homo sapiens_hsa05131	0.05452849
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.04670705

KIAA1524

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »