KIAA1524

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid segregation (GO:0000070)6.35716091
2sister chromatid segregation (GO:0000819)6.19115662
3protein localization to kinetochore (GO:0034501)6.13472982
4mitotic metaphase plate congression (GO:0007080)5.98227345
5mitotic chromosome condensation (GO:0007076)5.90329938
6protein localization to chromosome, centromeric region (GO:0071459)5.77190536
7regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.69648916
8kinetochore organization (GO:0051383)5.53261485
9CENP-A containing nucleosome assembly (GO:0034080)5.48157962
10metaphase plate congression (GO:0051310)5.47105616
11chromatin remodeling at centromere (GO:0031055)5.40587689
12nuclear pore complex assembly (GO:0051292)5.36940327
13DNA strand elongation involved in DNA replication (GO:0006271)5.17274064
14DNA unwinding involved in DNA replication (GO:0006268)5.11976542
15DNA strand elongation (GO:0022616)4.96869326
16mitotic sister chromatid cohesion (GO:0007064)4.91168902
17nuclear pore organization (GO:0006999)4.84185861
18telomere maintenance via semi-conservative replication (GO:0032201)4.78660827
19establishment of chromosome localization (GO:0051303)4.73340800
20kinetochore assembly (GO:0051382)4.58489651
21histone exchange (GO:0043486)4.58064013
22DNA replication checkpoint (GO:0000076)4.57705795
23DNA ligation (GO:0006266)4.53738525
24regulation of mitotic spindle organization (GO:0060236)4.48556261
25DNA topological change (GO:0006265)4.47918866
26regulation of spindle organization (GO:0090224)4.47454908
27regulation of centriole replication (GO:0046599)4.46161324
28spindle checkpoint (GO:0031577)4.45440270
29DNA replication-independent nucleosome organization (GO:0034724)4.42874624
30DNA replication-independent nucleosome assembly (GO:0006336)4.42874624
31meiotic chromosome segregation (GO:0045132)4.37523986
32mitotic recombination (GO:0006312)4.37047296
33regulation of chromosome segregation (GO:0051983)4.33184732
34establishment of integrated proviral latency (GO:0075713)4.25960287
35telomere maintenance via recombination (GO:0000722)4.23082625
36mitotic nuclear envelope disassembly (GO:0007077)4.22215079
37chromosome segregation (GO:0007059)4.20362679
38negative regulation of chromosome segregation (GO:0051985)4.19974457
39mitotic spindle checkpoint (GO:0071174)4.15511065
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.12104674
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.12104674
42negative regulation of mitotic sister chromatid segregation (GO:0033048)4.12104674
43negative regulation of mitotic sister chromatid separation (GO:2000816)4.12104674
44negative regulation of sister chromatid segregation (GO:0033046)4.12104674
45regulation of mitotic metaphase/anaphase transition (GO:0030071)4.03978973
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.03978973
47pore complex assembly (GO:0046931)4.00503532
48chromosome condensation (GO:0030261)3.99223123
49regulation of DNA endoreduplication (GO:0032875)3.98877272
50mitotic spindle assembly checkpoint (GO:0007094)3.97413245
51spindle assembly checkpoint (GO:0071173)3.96997489
52protein localization to chromosome (GO:0034502)3.96782123
53regulation of mitotic sister chromatid separation (GO:0010965)3.95914945
54regulation of mitotic sister chromatid segregation (GO:0033047)3.95914945
55regulation of sister chromatid segregation (GO:0033045)3.95914945
56positive regulation of chromosome segregation (GO:0051984)3.95717972
57DNA replication initiation (GO:0006270)3.94688050
58membrane disassembly (GO:0030397)3.90757861
59nuclear envelope disassembly (GO:0051081)3.90757861
60microtubule depolymerization (GO:0007019)3.90252418
61regulation of centrosome cycle (GO:0046605)3.89631666
62attachment of spindle microtubules to kinetochore (GO:0008608)3.86832293
63non-recombinational repair (GO:0000726)3.77899527
64double-strand break repair via nonhomologous end joining (GO:0006303)3.77899527
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.67446597
66mitotic G2/M transition checkpoint (GO:0044818)3.64925917
67DNA replication-dependent nucleosome organization (GO:0034723)3.60631179
68DNA replication-dependent nucleosome assembly (GO:0006335)3.60631179
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54549283
70chromatin assembly or disassembly (GO:0006333)3.53374137
71regulation of sister chromatid cohesion (GO:0007063)3.53018516
72ATP-dependent chromatin remodeling (GO:0043044)3.51778779
73DNA packaging (GO:0006323)3.51059927
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.49826538
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.49514102
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49514102
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49514102
78protein K6-linked ubiquitination (GO:0085020)3.48242665
79regulation of centrosome duplication (GO:0010824)3.43353342
80replication fork processing (GO:0031297)3.42154201
81telomere maintenance via telomere lengthening (GO:0010833)3.42007277
82IMP biosynthetic process (GO:0006188)3.34181672
83resolution of meiotic recombination intermediates (GO:0000712)3.31581715
84mitotic cell cycle (GO:0000278)3.30202492
85negative regulation of mitosis (GO:0045839)3.30091681
86regulation of double-strand break repair via homologous recombination (GO:0010569)3.29722038
87purine nucleobase biosynthetic process (GO:0009113)3.28642719
88DNA double-strand break processing (GO:0000729)3.28171717
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27652106
90histone-serine phosphorylation (GO:0035404)3.25676495
91mitotic spindle organization (GO:0007052)3.24252573
92DNA duplex unwinding (GO:0032508)3.24193498
93heterochromatin organization (GO:0070828)3.23686574
94DNA conformation change (GO:0071103)3.22852314
95spindle assembly involved in mitosis (GO:0090307)3.22840300
96DNA geometric change (GO:0032392)3.18801952
97establishment of viral latency (GO:0019043)3.18305147
98nucleobase biosynthetic process (GO:0046112)3.12429852
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11696724
100chromosome organization (GO:0051276)3.06153778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.52796449
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.54772760
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.73427115
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81372565
5AR_21909140_ChIP-Seq_LNCAP_Human3.73588572
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.53562790
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84223043
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.72566574
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.68938140
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67856898
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55069097
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51855119
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.51609919
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.46785363
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38683063
16* GABP_17652178_ChIP-ChIP_JURKAT_Human2.36884292
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35908261
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33708592
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33592812
20ELK1_19687146_ChIP-ChIP_HELA_Human2.27840821
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16924510
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16427871
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05818433
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02225996
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01325965
26E2F7_22180533_ChIP-Seq_HELA_Human10.2770462
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96673332
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.94420120
29DCP1A_22483619_ChIP-Seq_HELA_Human1.81952630
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78178506
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77654642
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75948196
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72725300
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72208847
35TTF2_22483619_ChIP-Seq_HELA_Human1.66775864
36FOXP3_21729870_ChIP-Seq_TREG_Human1.66597452
37XRN2_22483619_ChIP-Seq_HELA_Human1.65641767
38VDR_23849224_ChIP-Seq_CD4+_Human1.61087038
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60658537
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48626266
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47019638
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46726408
43* GABP_19822575_ChIP-Seq_HepG2_Human1.40406328
44E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.39571643
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35674263
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34743461
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30289726
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28547397
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25600329
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25143417
51MYC_18940864_ChIP-ChIP_HL60_Human1.23463981
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22482268
53EWS_26573619_Chip-Seq_HEK293_Human1.20794533
54KDM5A_27292631_Chip-Seq_BREAST_Human1.20701559
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.18592461
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17521955
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15181595
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.12122290
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.07788471
60ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05216392
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.02931122
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.00279759
63ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99971363
64RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97985996
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96746415
66POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96298590
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95914915
68SRF_21415370_ChIP-Seq_HL-1_Mouse0.95905207
69ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94932861
70FUS_26573619_Chip-Seq_HEK293_Human0.90651984
71KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86384784
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85926114
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84369385
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83741670
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81872651
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81344006
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80340966
78YY1_21170310_ChIP-Seq_MESCs_Mouse0.79310451
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78756399
80NANOG_21062744_ChIP-ChIP_HESCs_Human0.77796121
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77672096
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77287899
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76392389
84TFEB_21752829_ChIP-Seq_HELA_Human0.75556371
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75168120
86CIITA_25753668_ChIP-Seq_RAJI_Human0.74076511
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72928105
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72178309
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71966672
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70801924
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67175344
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67137601
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67046966
94CHD1_26751641_Chip-Seq_LNCaP_Human0.67031493
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.66396744
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.64946141
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64593212
98IRF1_19129219_ChIP-ChIP_H3396_Human0.64481376
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.63717824
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63164740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.96574126
2MP0003693_abnormal_embryo_hatching5.05979270
3MP0003111_abnormal_nucleus_morphology4.90832997
4MP0008057_abnormal_DNA_replication4.72309782
5MP0004957_abnormal_blastocyst_morpholog4.31283377
6MP0003077_abnormal_cell_cycle4.15298300
7MP0008058_abnormal_DNA_repair3.89911860
8MP0008932_abnormal_embryonic_tissue3.25226186
9MP0008007_abnormal_cellular_replicative2.90969914
10MP0009697_abnormal_copulation2.60384477
11MP0003890_abnormal_embryonic-extraembry2.29390006
12MP0003718_maternal_effect2.19110795
13MP0010307_abnormal_tumor_latency2.11287666
14MP0000350_abnormal_cell_proliferation2.02117004
15MP0001730_embryonic_growth_arrest2.00787103
16MP0010352_gastrointestinal_tract_polyps1.98763260
17MP0003786_premature_aging1.82271285
18MP0006292_abnormal_olfactory_placode1.82181032
19MP0001672_abnormal_embryogenesis/_devel1.79327363
20MP0005380_embryogenesis_phenotype1.79327363
21MP0001697_abnormal_embryo_size1.75191394
22MP0001293_anophthalmia1.70390397
23MP0003941_abnormal_skin_development1.66962711
24MP0002085_abnormal_embryonic_tissue1.58130007
25MP0003937_abnormal_limbs/digits/tail_de1.58122079
26MP0002084_abnormal_developmental_patter1.56903164
27MP0010030_abnormal_orbit_morphology1.53576463
28MP0003984_embryonic_growth_retardation1.49443240
29MP0002080_prenatal_lethality1.48611980
30MP0002088_abnormal_embryonic_growth/wei1.43714378
31MP0002396_abnormal_hematopoietic_system1.37645986
32MP0002697_abnormal_eye_size1.35392207
33MP0004197_abnormal_fetal_growth/weight/1.33346296
34MP0009672_abnormal_birth_weight1.32170930
35MP0000313_abnormal_cell_death1.29016834
36MP0002877_abnormal_melanocyte_morpholog1.28299277
37MP0003806_abnormal_nucleotide_metabolis1.23906864
38MP0008877_abnormal_DNA_methylation1.23421842
39MP0001286_abnormal_eye_development1.22428226
40MP0002938_white_spotting1.18938184
41MP0002210_abnormal_sex_determination1.16199846
42MP0002086_abnormal_extraembryonic_tissu1.13986775
43MP0002234_abnormal_pharynx_morphology1.09461420
44MP0001929_abnormal_gametogenesis1.07426182
45MP0002111_abnormal_tail_morphology1.07322022
46MP0003705_abnormal_hypodermis_morpholog1.05329702
47MP0003567_abnormal_fetal_cardiomyocyte1.01939732
48MP0003950_abnormal_plasma_membrane0.99948139
49MP0000428_abnormal_craniofacial_morphol0.97390118
50MP0002233_abnormal_nose_morphology0.97166171
51MP0002019_abnormal_tumor_incidence0.96686608
52MP0003136_yellow_coat_color0.96372550
53MP0000358_abnormal_cell_content/0.96002574
54MP0003119_abnormal_digestive_system0.95485408
55MP0002009_preneoplasia0.95265975
56MP0001145_abnormal_male_reproductive0.94207006
57MP0000537_abnormal_urethra_morphology0.93083851
58MP0006035_abnormal_mitochondrial_morpho0.91521301
59MP0005623_abnormal_meninges_morphology0.91037412
60MP0003755_abnormal_palate_morphology0.90923988
61MP0002092_abnormal_eye_morphology0.90249146
62MP0003315_abnormal_perineum_morphology0.89645164
63MP0002160_abnormal_reproductive_system0.89338423
64MP0009703_decreased_birth_body0.87344405
65MP0005076_abnormal_cell_differentiation0.86567594
66MP0000653_abnormal_sex_gland0.85287557
67MP0008789_abnormal_olfactory_epithelium0.83054618
68MP0009053_abnormal_anal_canal0.82497038
69MP0000372_irregular_coat_pigmentation0.80351927
70MP0003385_abnormal_body_wall0.80210593
71MP0000490_abnormal_crypts_of0.78947249
72MP0003935_abnormal_craniofacial_develop0.75804693
73MP0001119_abnormal_female_reproductive0.74721101
74MP0004185_abnormal_adipocyte_glucose0.74185413
75MP0003861_abnormal_nervous_system0.74131566
76MP0001529_abnormal_vocalization0.72889397
77MP0000647_abnormal_sebaceous_gland0.72856099
78MP0005395_other_phenotype0.71722971
79MP0005384_cellular_phenotype0.71478802
80MP0006072_abnormal_retinal_apoptosis0.69243485
81MP0000432_abnormal_head_morphology0.68145879
82MP0005621_abnormal_cell_physiology0.68092354
83MP0003943_abnormal_hepatobiliary_system0.67589198
84MP0001299_abnormal_eye_distance/0.67217892
85MP0001346_abnormal_lacrimal_gland0.67077855
86MP0005499_abnormal_olfactory_system0.64935569
87MP0005394_taste/olfaction_phenotype0.64935569
88MP0000049_abnormal_middle_ear0.64835532
89MP0003699_abnormal_female_reproductive0.64020779
90MP0003121_genomic_imprinting0.63276081
91MP0000762_abnormal_tongue_morphology0.60595783
92MP0002102_abnormal_ear_morphology0.60238833
93MP0005391_vision/eye_phenotype0.58975901
94MP0002161_abnormal_fertility/fecundity0.58199290
95MP0003698_abnormal_male_reproductive0.57964023
96MP0002177_abnormal_outer_ear0.55588543
97MP0005171_absent_coat_pigmentation0.55023597
98MP0002751_abnormal_autonomic_nervous0.55007005
99MP0005501_abnormal_skin_physiology0.54510112
100MP0003566_abnormal_cell_adhesion0.53938673

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)7.20699662
2Chromsome breakage (HP:0040012)6.74722760
3Abnormality of chromosome stability (HP:0003220)4.84658341
4Meckel diverticulum (HP:0002245)4.75438714
5Aplasia/Hypoplasia of the uvula (HP:0010293)4.63933171
6Abnormality of the ileum (HP:0001549)4.56977839
7Abnormality of the preputium (HP:0100587)4.46771020
8Small intestinal stenosis (HP:0012848)4.09068592
9Duodenal stenosis (HP:0100867)4.09068592
10Volvulus (HP:0002580)3.88143343
11Increased nuchal translucency (HP:0010880)3.70929446
12Nephroblastoma (Wilms tumor) (HP:0002667)3.67388806
13Abnormal lung lobation (HP:0002101)3.65741728
14Embryonal renal neoplasm (HP:0011794)3.62424314
15Abnormality of the duodenum (HP:0002246)3.52050744
16Birth length less than 3rd percentile (HP:0003561)3.47403242
17Abnormality of the carotid arteries (HP:0005344)3.39437052
18Myelodysplasia (HP:0002863)3.27850467
19Cortical dysplasia (HP:0002539)3.08868739
20Sloping forehead (HP:0000340)2.96863735
21Clubbing of toes (HP:0100760)2.95271630
22Absent radius (HP:0003974)2.83671200
23Triphalangeal thumb (HP:0001199)2.74052209
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73525527
25Ectopic kidney (HP:0000086)2.69214743
26Abnormality of the labia minora (HP:0012880)2.67177495
27Aplasia involving forearm bones (HP:0009822)2.64166150
28Absent forearm bone (HP:0003953)2.64166150
29Colon cancer (HP:0003003)2.61679528
30Cafe-au-lait spot (HP:0000957)2.54913589
31Rhabdomyosarcoma (HP:0002859)2.54273377
32Reticulocytopenia (HP:0001896)2.49943388
33Ependymoma (HP:0002888)2.41147481
34Medulloblastoma (HP:0002885)2.38458934
35Abnormality of the fetal cardiovascular system (HP:0010948)2.32643671
36Abnormal umbilical cord blood vessels (HP:0011403)2.32643671
37Single umbilical artery (HP:0001195)2.32643671
38Arteriovenous malformation (HP:0100026)2.30288543
39Horseshoe kidney (HP:0000085)2.27186480
40Choanal atresia (HP:0000453)2.25397448
41Duplicated collecting system (HP:0000081)2.24217797
42Glioma (HP:0009733)2.19594358
43Embryonal neoplasm (HP:0002898)2.16921627
44Hypoplastic pelvis (HP:0008839)2.15451009
45Selective tooth agenesis (HP:0001592)2.15156075
46Proximal placement of thumb (HP:0009623)2.13929183
47Neoplasm of the colon (HP:0100273)2.11716722
48Short thumb (HP:0009778)2.10387103
49Abnormality of chromosome segregation (HP:0002916)2.05402391
50Deviation of the thumb (HP:0009603)2.04558919
51Aplasia/Hypoplasia of the sternum (HP:0006714)1.98914857
52Breast hypoplasia (HP:0003187)1.97970030
53Absent thumb (HP:0009777)1.94739376
54Abnormal number of incisors (HP:0011064)1.94665996
55Abnormality of the umbilical cord (HP:0010881)1.94024246
56Multiple enchondromatosis (HP:0005701)1.91848910
57Abnormality of the astrocytes (HP:0100707)1.91806852
58Astrocytoma (HP:0009592)1.91806852
59Bone marrow hypocellularity (HP:0005528)1.90562443
60Patellar aplasia (HP:0006443)1.89649352
61Supernumerary spleens (HP:0009799)1.88152112
62Missing ribs (HP:0000921)1.86679516
63Abnormality of the renal collecting system (HP:0004742)1.85798178
64Abnormality of DNA repair (HP:0003254)1.85194242
65Duplication of thumb phalanx (HP:0009942)1.82980191
66Tracheoesophageal fistula (HP:0002575)1.80242773
67Microvesicular hepatic steatosis (HP:0001414)1.77720804
68Facial hemangioma (HP:0000329)1.77558902
69High pitched voice (HP:0001620)1.76190917
70Aplasia/Hypoplasia of the patella (HP:0006498)1.71422632
71Abnormality of the septum pellucidum (HP:0007375)1.70767077
72Overlapping toe (HP:0001845)1.69861337
73Bilateral microphthalmos (HP:0007633)1.68800889
74Small hand (HP:0200055)1.68612941
75Ovarian neoplasm (HP:0100615)1.66788281
76Intestinal atresia (HP:0011100)1.64313854
77Squamous cell carcinoma (HP:0002860)1.62874069
78Abnormality of the pons (HP:0007361)1.62760934
79Facial cleft (HP:0002006)1.62421029
80Prominent nose (HP:0000448)1.62185733
81Facial asymmetry (HP:0000324)1.62052880
82Abnormal auditory evoked potentials (HP:0006958)1.61801470
83Deep philtrum (HP:0002002)1.59633921
84Absent septum pellucidum (HP:0001331)1.59560355
85Neoplasm of striated muscle (HP:0009728)1.58599366
86Septo-optic dysplasia (HP:0100842)1.58434524
87Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57224178
88Progressive external ophthalmoplegia (HP:0000590)1.56324680
89Hypoplasia of the pons (HP:0012110)1.56047718
90Poikiloderma (HP:0001029)1.55653991
91Carpal bone hypoplasia (HP:0001498)1.54270066
92Impulsivity (HP:0100710)1.52363486
93Atresia of the external auditory canal (HP:0000413)1.52282719
94Astigmatism (HP:0000483)1.51752843
95Renal agenesis (HP:0000104)1.51221959
96Abnormality of cochlea (HP:0000375)1.51150473
97High anterior hairline (HP:0009890)1.51084381
98Oligohydramnios (HP:0001562)1.50570790
99Malignant gastrointestinal tract tumors (HP:0006749)1.50469063
100Gastrointestinal carcinoma (HP:0002672)1.50469063

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.61209286
2CDC74.21684600
3TTK4.20582780
4NEK13.63021642
5WEE13.44065870
6PLK43.27399131
7PBK3.04500650
8SRPK12.76787511
9BRSK22.62501071
10PLK32.50707731
11NEK22.36762448
12TSSK62.34756994
13ZAK2.33267293
14PLK12.18338701
15MKNK22.13623540
16MKNK12.06197577
17EIF2AK11.98063591
18VRK21.87256071
19CHEK21.85471857
20BRSK11.76524225
21EIF2AK31.68549333
22AURKB1.62926870
23ATR1.56810621
24TRIM281.53752503
25CCNB11.53300962
26TAF11.49956988
27VRK11.48273199
28MST41.44573030
29PNCK1.30658250
30NUAK11.20028507
31CDK71.14508155
32STK31.14115856
33CHEK11.12965554
34EIF2AK21.11332236
35STK101.08420728
36MELK1.06066661
37AURKA0.99533823
38BRD40.98498705
39ATM0.98092160
40BMPR1B0.95338790
41ERBB40.94789567
42SCYL20.93638914
43STK40.92191563
44LATS10.88944935
45MAP3K80.88855779
46BRAF0.85360568
47ACVR1B0.84098776
48CDK40.79679782
49CDK80.78838630
50MAP3K100.78783065
51BCR0.75989630
52MST1R0.72664071
53CDK10.72516342
54CDK120.72492817
55ERBB30.71901879
56NME20.68854444
57CLK10.66946480
58CDK60.63918341
59WNK30.63852162
60TLK10.63761131
61RPS6KB20.62361793
62PAK40.62100177
63TNIK0.60320438
64CDK20.60008600
65STK160.58424506
66ALK0.58153905
67SMG10.57864477
68PLK20.54151817
69RPS6KA40.53930444
70PASK0.52470384
71MET0.51949775
72TGFBR10.45505159
73LATS20.42155836
74CDK90.41966154
75CSNK2A10.41591626
76CSNK2A20.40159897
77PRKDC0.39479719
78PRKCI0.39461811
79FGFR10.37902573
80CDK180.37874681
81STK38L0.36835641
82CDK150.34133979
83PAK10.33583018
84MARK30.33101325
85CSNK1E0.32101808
86PDK20.31842065
87CDK11A0.31643966
88CDK140.31550245
89NEK90.31059102
90CSNK1G10.30529766
91CDK30.28105794
92AKT20.22914428
93DYRK30.21137560
94NME10.20967457
95MAPK140.18858647
96CSNK1G30.18281555
97MAP3K40.17789113
98FLT30.16718661
99CSNK1A1L0.16363678
100UHMK10.14855375

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.21177752
2Mismatch repair_Homo sapiens_hsa034304.60894892
3Non-homologous end-joining_Homo sapiens_hsa034503.81823617
4Homologous recombination_Homo sapiens_hsa034403.54524221
5Cell cycle_Homo sapiens_hsa041103.53830041
6Fanconi anemia pathway_Homo sapiens_hsa034603.34879450
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19758404
8Base excision repair_Homo sapiens_hsa034102.99147721
9Nucleotide excision repair_Homo sapiens_hsa034202.88680673
10Proteasome_Homo sapiens_hsa030502.74836680
11Spliceosome_Homo sapiens_hsa030402.67186858
12RNA transport_Homo sapiens_hsa030132.64533487
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62856090
14One carbon pool by folate_Homo sapiens_hsa006702.29546508
15Basal transcription factors_Homo sapiens_hsa030221.95892974
16RNA polymerase_Homo sapiens_hsa030201.91235399
17Pyrimidine metabolism_Homo sapiens_hsa002401.83178332
18RNA degradation_Homo sapiens_hsa030181.77243211
19p53 signaling pathway_Homo sapiens_hsa041151.65450134
20mRNA surveillance pathway_Homo sapiens_hsa030151.61393853
21Oocyte meiosis_Homo sapiens_hsa041141.53527203
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.46665180
23Protein export_Homo sapiens_hsa030601.45218925
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29693908
25Ribosome_Homo sapiens_hsa030101.27763084
26Selenocompound metabolism_Homo sapiens_hsa004501.27473355
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20299700
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19566695
29Biosynthesis of amino acids_Homo sapiens_hsa012301.16658386
30Purine metabolism_Homo sapiens_hsa002301.15468621
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14026984
32Pyruvate metabolism_Homo sapiens_hsa006201.08815849
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04889497
34Vitamin B6 metabolism_Homo sapiens_hsa007501.03945142
35Steroid biosynthesis_Homo sapiens_hsa001000.97215879
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87229896
37Systemic lupus erythematosus_Homo sapiens_hsa053220.85242317
38Carbon metabolism_Homo sapiens_hsa012000.80981821
39Folate biosynthesis_Homo sapiens_hsa007900.80395231
40Propanoate metabolism_Homo sapiens_hsa006400.79386855
41Fatty acid elongation_Homo sapiens_hsa000620.78818870
42Hippo signaling pathway_Homo sapiens_hsa043900.77498208
43MicroRNAs in cancer_Homo sapiens_hsa052060.77465519
44TGF-beta signaling pathway_Homo sapiens_hsa043500.77229183
45Viral carcinogenesis_Homo sapiens_hsa052030.73221328
46Lysine degradation_Homo sapiens_hsa003100.71960301
47Alcoholism_Homo sapiens_hsa050340.67899951
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66404460
49Basal cell carcinoma_Homo sapiens_hsa052170.65764397
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62365611
51Pentose phosphate pathway_Homo sapiens_hsa000300.61167871
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61145933
53Adherens junction_Homo sapiens_hsa045200.60450675
54Thyroid cancer_Homo sapiens_hsa052160.60096262
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58928112
56N-Glycan biosynthesis_Homo sapiens_hsa005100.58796270
57Epstein-Barr virus infection_Homo sapiens_hsa051690.58605442
58Glutathione metabolism_Homo sapiens_hsa004800.58388925
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58293747
60Huntingtons disease_Homo sapiens_hsa050160.57754473
61Small cell lung cancer_Homo sapiens_hsa052220.54492912
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53412567
63Colorectal cancer_Homo sapiens_hsa052100.47192563
64Wnt signaling pathway_Homo sapiens_hsa043100.46899038
65Hedgehog signaling pathway_Homo sapiens_hsa043400.46791475
66HTLV-I infection_Homo sapiens_hsa051660.43524357
67Parkinsons disease_Homo sapiens_hsa050120.42610234
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42011031
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39688413
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38683685
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34650136
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34041502
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33570454
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33362831
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31174210
76Sulfur relay system_Homo sapiens_hsa041220.30266465
77Metabolic pathways_Homo sapiens_hsa011000.29631224
78Prostate cancer_Homo sapiens_hsa052150.29370952
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.28047936
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26614376
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26204536
82Oxidative phosphorylation_Homo sapiens_hsa001900.25870754
83Pancreatic cancer_Homo sapiens_hsa052120.24137796
84Melanoma_Homo sapiens_hsa052180.22895079
85Fatty acid metabolism_Homo sapiens_hsa012120.22757318
86Bladder cancer_Homo sapiens_hsa052190.21596864
87Herpes simplex infection_Homo sapiens_hsa051680.19143775
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.17006925
89Pathways in cancer_Homo sapiens_hsa052000.15798925
90Proteoglycans in cancer_Homo sapiens_hsa052050.15611001
91Chronic myeloid leukemia_Homo sapiens_hsa052200.13698277
92Hepatitis B_Homo sapiens_hsa051610.10102486
93Alzheimers disease_Homo sapiens_hsa050100.09694557
94Arginine and proline metabolism_Homo sapiens_hsa003300.07856334
95Tight junction_Homo sapiens_hsa045300.07778872
96Olfactory transduction_Homo sapiens_hsa047400.07535324
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.07174555
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05991304
99Shigellosis_Homo sapiens_hsa051310.05452849
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.04670705

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