KIAA1549

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the UPF0606 family. This gene has been found to be fused to the BRAF oncogene in many cases of pilocytic astrocytoma. The fusion results from 2Mb tandem duplications at 7q34. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.59728421
2nucleobase catabolic process (GO:0046113)4.43504728
3presynaptic membrane assembly (GO:0097105)4.28955833
4axonal fasciculation (GO:0007413)4.22571644
5neuron recognition (GO:0008038)4.20666664
6postsynaptic membrane organization (GO:0001941)4.18958100
7presynaptic membrane organization (GO:0097090)3.99559591
8neuron cell-cell adhesion (GO:0007158)3.93345538
9central nervous system projection neuron axonogenesis (GO:0021952)3.92478432
10behavioral response to nicotine (GO:0035095)3.88826889
11cell migration in hindbrain (GO:0021535)3.77784114
12regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58262941
13vocalization behavior (GO:0071625)3.37494190
14establishment of mitochondrion localization (GO:0051654)3.33654407
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.32622396
16retinal ganglion cell axon guidance (GO:0031290)3.26578189
17auditory behavior (GO:0031223)3.26546044
18dendritic spine morphogenesis (GO:0060997)3.21368462
19central nervous system neuron axonogenesis (GO:0021955)3.19084921
20synapse assembly (GO:0007416)3.17591829
21dendrite morphogenesis (GO:0048813)3.15749132
22limb bud formation (GO:0060174)3.11839754
23protein localization to synapse (GO:0035418)3.06350639
24establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05650142
25mitochondrion transport along microtubule (GO:0047497)3.05650142
26axon extension (GO:0048675)3.04897129
27sympathetic nervous system development (GO:0048485)3.03996200
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.03486097
29positive regulation of dendritic spine morphogenesis (GO:0061003)3.01406490
30regulation of axon guidance (GO:1902667)2.89585307
31positive regulation of synapse assembly (GO:0051965)2.87873763
32spinal cord development (GO:0021510)2.86997579
33mechanosensory behavior (GO:0007638)2.85681237
34axon extension involved in axon guidance (GO:0048846)2.84240835
35neuron projection extension involved in neuron projection guidance (GO:1902284)2.84240835
36regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82120089
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82000425
38transmission of nerve impulse (GO:0019226)2.80097883
39response to auditory stimulus (GO:0010996)2.77848454
40cerebral cortex radially oriented cell migration (GO:0021799)2.76501747
41calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.73145375
42glutamate receptor signaling pathway (GO:0007215)2.71510074
43neurotransmitter-gated ion channel clustering (GO:0072578)2.71043858
44regulation of axon extension involved in axon guidance (GO:0048841)2.69379528
45dopaminergic neuron differentiation (GO:0071542)2.67780727
46synaptic transmission, glutamatergic (GO:0035249)2.67503449
47hindbrain development (GO:0030902)2.63486327
48layer formation in cerebral cortex (GO:0021819)2.61404219
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59933049
50cranial nerve morphogenesis (GO:0021602)2.59149968
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57554242
52ganglion development (GO:0061548)2.57461505
53negative regulation of axon guidance (GO:1902668)2.55777315
54startle response (GO:0001964)2.54605204
55short-term memory (GO:0007614)2.53270458
56synapse organization (GO:0050808)2.52954362
57neuron migration (GO:0001764)2.52412124
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52111405
59behavioral response to ethanol (GO:0048149)2.50218996
60regulation of synapse assembly (GO:0051963)2.47427941
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47246038
62apical protein localization (GO:0045176)2.47140498
63neuron projection extension (GO:1990138)2.44044997
64hippocampus development (GO:0021766)2.44011986
65neurofilament cytoskeleton organization (GO:0060052)2.43032992
66negative regulation of axon extension (GO:0030517)2.43012326
67retina layer formation (GO:0010842)2.42978812
68axonogenesis (GO:0007409)2.39307144
69negative chemotaxis (GO:0050919)2.39278736
70somite development (GO:0061053)2.38907181
71limb development (GO:0060173)2.36128375
72appendage development (GO:0048736)2.36128375
73regulation of synapse structural plasticity (GO:0051823)2.35893249
74dendrite development (GO:0016358)2.34587745
75neuron-neuron synaptic transmission (GO:0007270)2.34538808
76adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.34220517
77adult walking behavior (GO:0007628)2.33761203
78regulation of respiratory system process (GO:0044065)2.33196722
79behavioral fear response (GO:0001662)2.33039754
80behavioral defense response (GO:0002209)2.33039754
81innervation (GO:0060384)2.32812479
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.31943068
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.31225695
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.31225695
85regulation of translation, ncRNA-mediated (GO:0045974)2.31225695
86gamma-aminobutyric acid transport (GO:0015812)2.28356749
87establishment of nucleus localization (GO:0040023)2.28333767
88homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.25069167
89fear response (GO:0042596)2.24765383
90exploration behavior (GO:0035640)2.23730962
91regulation of respiratory gaseous exchange (GO:0043576)2.23140363
92positive regulation of action potential (GO:0045760)2.21373000
93negative regulation of dendrite development (GO:2000171)2.21151094
94negative regulation of axonogenesis (GO:0050771)2.20838061
95neuronal action potential (GO:0019228)2.20288893
96cerebral cortex cell migration (GO:0021795)2.20070257
97intraciliary transport (GO:0042073)2.19343059
98spinal cord motor neuron differentiation (GO:0021522)2.18960099
99neuromuscular synaptic transmission (GO:0007274)2.18394276
100ephrin receptor signaling pathway (GO:0048013)2.18314134

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54139590
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14195388
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.07960910
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02852756
5GBX2_23144817_ChIP-Seq_PC3_Human2.91012682
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65537311
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.54830821
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.51654335
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33841013
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26495679
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.17285796
12REST_21632747_ChIP-Seq_MESCs_Mouse2.11449026
13TAF15_26573619_Chip-Seq_HEK293_Human2.04665476
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04545251
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01719091
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.01523715
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99397053
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99397053
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.98739077
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97450805
21RNF2_27304074_Chip-Seq_NSC_Mouse1.94829668
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94017620
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92175504
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91811204
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.91229896
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87167547
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.82390837
28ZNF274_21170338_ChIP-Seq_K562_Hela1.81160330
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80730300
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.78212396
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77967554
32IGF1R_20145208_ChIP-Seq_DFB_Human1.77757256
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74802627
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73266062
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72429560
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69532116
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.69501570
38FUS_26573619_Chip-Seq_HEK293_Human1.68949624
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68562253
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65861943
41P300_19829295_ChIP-Seq_ESCs_Human1.60499708
42AR_21572438_ChIP-Seq_LNCaP_Human1.57559506
43DROSHA_22980978_ChIP-Seq_HELA_Human1.56984142
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56310114
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.53361535
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50694017
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.49568664
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49165732
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.48091685
50VDR_22108803_ChIP-Seq_LS180_Human1.47765874
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45001864
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.44773330
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43998801
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42074212
55EWS_26573619_Chip-Seq_HEK293_Human1.41532096
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40177627
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38096873
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38096873
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36671180
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35511138
61* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33796809
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33749407
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.33100462
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.31563305
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30783639
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28391046
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26327550
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.25450462
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24875494
70STAT3_23295773_ChIP-Seq_U87_Human1.22160832
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19994641
72AR_25329375_ChIP-Seq_VCAP_Human1.19672023
73SOX9_26525672_Chip-Seq_HEART_Mouse1.19037671
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18437146
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17783674
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15833913
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.14277049
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11355666
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.09743127
80AR_19668381_ChIP-Seq_PC3_Human1.08156337
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08098979
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08007625
83RUNX2_22187159_ChIP-Seq_PCA_Human1.07882589
84TCF4_23295773_ChIP-Seq_U87_Human1.07358513
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05719391
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05317958
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.03944066
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03682600
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03158372
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02750444
91* ARNT_22903824_ChIP-Seq_MCF-7_Human1.00929452
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00028843
93* AHR_22903824_ChIP-Seq_MCF-7_Human0.99286586
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.99180233
95TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98924451
96TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98860499
97JUN_21703547_ChIP-Seq_K562_Human0.97307225
98WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96479137
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96220504
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94243806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000778_abnormal_nervous_system2.87316072
2MP0004859_abnormal_synaptic_plasticity2.74382327
3MP0003880_abnormal_central_pattern2.55005572
4MP0000566_synostosis2.32531943
5MP0004270_analgesia2.28778470
6MP0002822_catalepsy2.24317277
7MP0003122_maternal_imprinting2.24079419
8MP0005423_abnormal_somatic_nervous2.22768801
9MP0003635_abnormal_synaptic_transmissio2.08122240
10MP0000569_abnormal_digit_pigmentation1.87340390
11MP0002184_abnormal_innervation1.85782481
12MP0002735_abnormal_chemical_nociception1.84827609
13MP0006276_abnormal_autonomic_nervous1.82891718
14MP0003787_abnormal_imprinting1.79143508
15MP0002063_abnormal_learning/memory/cond1.78074355
16MP0003121_genomic_imprinting1.75304299
17MP0002572_abnormal_emotion/affect_behav1.72671182
18MP0002734_abnormal_mechanical_nocicepti1.72525829
19MP0000955_abnormal_spinal_cord1.71659356
20MP0001529_abnormal_vocalization1.66582573
21MP0001968_abnormal_touch/_nociception1.61861036
22MP0002638_abnormal_pupillary_reflex1.60627252
23MP0009745_abnormal_behavioral_response1.55639544
24MP0003937_abnormal_limbs/digits/tail_de1.55401618
25MP0004885_abnormal_endolymph1.52069888
26MP0004133_heterotaxia1.49483713
27MP0002751_abnormal_autonomic_nervous1.47405260
28MP0001486_abnormal_startle_reflex1.47054890
29MP0002557_abnormal_social/conspecific_i1.46902808
30MP0002272_abnormal_nervous_system1.46821367
31MP0001984_abnormal_olfaction1.46618516
32MP0003890_abnormal_embryonic-extraembry1.46616470
33MP0001188_hyperpigmentation1.46564398
34MP0000049_abnormal_middle_ear1.45042797
35MP0002736_abnormal_nociception_after1.44932529
36MP0003283_abnormal_digestive_organ1.43619669
37MP0000631_abnormal_neuroendocrine_gland1.43238275
38MP0003861_abnormal_nervous_system1.42577304
39MP0005187_abnormal_penis_morphology1.40995187
40MP0006292_abnormal_olfactory_placode1.40312062
41MP0003942_abnormal_urinary_system1.38534723
42MP0002064_seizures1.38078339
43MP0003136_yellow_coat_color1.37956441
44MP0009046_muscle_twitch1.37927664
45MP0002882_abnormal_neuron_morphology1.37896021
46MP0002234_abnormal_pharynx_morphology1.35849789
47MP0002938_white_spotting1.33478010
48MP0000537_abnormal_urethra_morphology1.30019893
49MP0002152_abnormal_brain_morphology1.28852271
50MP0002102_abnormal_ear_morphology1.27149919
51MP0004811_abnormal_neuron_physiology1.25043563
52MP0000534_abnormal_ureter_morphology1.24956092
53MP0002067_abnormal_sensory_capabilities1.23873478
54MP0003755_abnormal_palate_morphology1.23775793
55MP0002752_abnormal_somatic_nervous1.23564231
56MP0001299_abnormal_eye_distance/1.23125064
57MP0010030_abnormal_orbit_morphology1.21791922
58MP0008877_abnormal_DNA_methylation1.20755943
59MP0002233_abnormal_nose_morphology1.18070601
60MP0001970_abnormal_pain_threshold1.17427323
61MP0004924_abnormal_behavior1.15540619
62MP0005386_behavior/neurological_phenoty1.15540619
63MP0003119_abnormal_digestive_system1.13128866
64MP0002733_abnormal_thermal_nociception1.12462227
65MP0003938_abnormal_ear_development1.11166115
66MP0002697_abnormal_eye_size1.10534541
67MP0001293_anophthalmia1.08935273
68MP0004742_abnormal_vestibular_system1.07079063
69MP0002249_abnormal_larynx_morphology1.04982684
70MP0004145_abnormal_muscle_electrophysio1.03802443
71MP0003935_abnormal_craniofacial_develop1.03474022
72MP0000026_abnormal_inner_ear1.00882407
73MP0005646_abnormal_pituitary_gland1.00266578
74MP0001286_abnormal_eye_development0.99868417
75MP0005551_abnormal_eye_electrophysiolog0.99837639
76MP0002909_abnormal_adrenal_gland0.99686019
77MP0008789_abnormal_olfactory_epithelium0.98910375
78MP0000579_abnormal_nail_morphology0.98597947
79MP0003385_abnormal_body_wall0.98498860
80MP0005645_abnormal_hypothalamus_physiol0.98436068
81MP0005499_abnormal_olfactory_system0.96636118
82MP0005394_taste/olfaction_phenotype0.96636118
83MP0002116_abnormal_craniofacial_bone0.94627424
84MP0001440_abnormal_grooming_behavior0.94319701
85MP0004142_abnormal_muscle_tone0.93694265
86MP0001485_abnormal_pinna_reflex0.93151870
87MP0009250_abnormal_appendicular_skeleto0.90875998
88MP0002081_perinatal_lethality0.90786238
89MP0003123_paternal_imprinting0.89732951
90MP0002653_abnormal_ependyma_morphology0.89350738
91MP0002066_abnormal_motor_capabilities/c0.89303841
92MP0001502_abnormal_circadian_rhythm0.87712594
93MP0005195_abnormal_posterior_eye0.87439184
94MP0001905_abnormal_dopamine_level0.85369355
95MP0006072_abnormal_retinal_apoptosis0.82808242
96MP0009053_abnormal_anal_canal0.79141166
97MP0005503_abnormal_tendon_morphology0.79053108
98MP0003315_abnormal_perineum_morphology0.78460360
99MP0005623_abnormal_meninges_morphology0.77911559
100MP0010386_abnormal_urinary_bladder0.77809833

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.13263823
2Limb dystonia (HP:0002451)2.99285731
3Myokymia (HP:0002411)2.78829399
4Drooling (HP:0002307)2.66354291
5Volvulus (HP:0002580)2.62682769
6Focal seizures (HP:0007359)2.61443723
7Focal motor seizures (HP:0011153)2.58179643
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.45705522
9Short 4th metacarpal (HP:0010044)2.45705522
10Cutaneous finger syndactyly (HP:0010554)2.39280539
11Broad-based gait (HP:0002136)2.37522213
12Lissencephaly (HP:0001339)2.33864762
13Excessive salivation (HP:0003781)2.31539365
14Shawl scrotum (HP:0000049)2.30685301
15Abnormality of the corticospinal tract (HP:0002492)2.29167790
16Progressive cerebellar ataxia (HP:0002073)2.28481245
17Nephronophthisis (HP:0000090)2.27615030
18Gait imbalance (HP:0002141)2.23462333
19Genetic anticipation (HP:0003743)2.22695417
20Pachygyria (HP:0001302)2.21087849
21Abnormality of the 4th metacarpal (HP:0010012)2.19203019
22High anterior hairline (HP:0009890)2.17792880
23Midline defect of the nose (HP:0004122)2.16230610
24Morphological abnormality of the middle ear (HP:0008609)2.13013690
25Cutaneous syndactyly (HP:0012725)2.07669207
26Hepatoblastoma (HP:0002884)2.05912677
27Genital tract atresia (HP:0001827)2.02910462
28Abnormality of midbrain morphology (HP:0002418)2.02459926
29Molar tooth sign on MRI (HP:0002419)2.02459926
30Pancreatic fibrosis (HP:0100732)2.01737127
31True hermaphroditism (HP:0010459)2.00289542
32Vaginal atresia (HP:0000148)1.98502648
33Anophthalmia (HP:0000528)1.97868937
34Hypoplasia of the brainstem (HP:0002365)1.96314743
35Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96314743
36Retinal dysplasia (HP:0007973)1.95936868
37Exotropia (HP:0000577)1.93236838
38Absent speech (HP:0001344)1.92015416
39Type II lissencephaly (HP:0007260)1.90791234
40Renal hypoplasia (HP:0000089)1.90781057
41Patellar aplasia (HP:0006443)1.90029447
42Epileptic encephalopathy (HP:0200134)1.89890263
43Intestinal atresia (HP:0011100)1.87312132
44Bilateral microphthalmos (HP:0007633)1.85513835
45Polyphagia (HP:0002591)1.85165052
46Abnormality of the renal medulla (HP:0100957)1.84996623
47Pancreatic cysts (HP:0001737)1.82550510
48Amblyopia (HP:0000646)1.82481978
49Partial agenesis of the corpus callosum (HP:0001338)1.80278406
50Bifid tongue (HP:0010297)1.79221561
51Tented upper lip vermilion (HP:0010804)1.79110921
52Abnormality of the labia minora (HP:0012880)1.78015573
53Protruding tongue (HP:0010808)1.75467247
54Aplasia/Hypoplasia of the patella (HP:0006498)1.74844674
55Abnormal number of incisors (HP:0011064)1.74053477
56Febrile seizures (HP:0002373)1.72501386
57Aplasia/Hypoplasia of the sternum (HP:0006714)1.72311695
58Optic nerve hypoplasia (HP:0000609)1.72019760
59Congenital primary aphakia (HP:0007707)1.67401242
60Abnormality of the aortic arch (HP:0012303)1.67359023
61Agitation (HP:0000713)1.67314728
62Abnormality of the diencephalon (HP:0010662)1.67172313
63Oligodactyly (hands) (HP:0001180)1.67043370
64Chronic hepatic failure (HP:0100626)1.66578158
65Aqueductal stenosis (HP:0002410)1.66307385
66Sclerocornea (HP:0000647)1.65501156
67Elfin facies (HP:0004428)1.65053248
68Medial flaring of the eyebrow (HP:0010747)1.65028706
69Aplasia/Hypoplasia of the tibia (HP:0005772)1.64932501
70Renovascular hypertension (HP:0100817)1.64515942
71Preaxial foot polydactyly (HP:0001841)1.64164545
72Amyotrophic lateral sclerosis (HP:0007354)1.62854209
73Cortical dysplasia (HP:0002539)1.62575887
74Nephrogenic diabetes insipidus (HP:0009806)1.62039062
75Epileptiform EEG discharges (HP:0011182)1.60570278
76Postaxial hand polydactyly (HP:0001162)1.60275896
77Micropenis (HP:0000054)1.60140925
78Obsessive-compulsive behavior (HP:0000722)1.58969988
79EEG with generalized epileptiform discharges (HP:0011198)1.57662842
80Hypsarrhythmia (HP:0002521)1.57372654
81Cupped ear (HP:0000378)1.56608147
82Megalencephaly (HP:0001355)1.55680133
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.54701511
84Degeneration of the lateral corticospinal tracts (HP:0002314)1.54701511
85Gaze-evoked nystagmus (HP:0000640)1.54542815
86Urinary bladder sphincter dysfunction (HP:0002839)1.53472369
87Cerebellar dysplasia (HP:0007033)1.53393671
88Postaxial foot polydactyly (HP:0001830)1.53302033
89Overriding aorta (HP:0002623)1.53012949
90Highly arched eyebrow (HP:0002553)1.52301654
91Gastrointestinal atresia (HP:0002589)1.51487804
92Fetal akinesia sequence (HP:0001989)1.50333308
93Narrow forehead (HP:0000341)1.50216655
94Sacral dimple (HP:0000960)1.49948618
95Gastroesophageal reflux (HP:0002020)1.49411623
96Preaxial hand polydactyly (HP:0001177)1.49255462
97Intellectual disability, moderate (HP:0002342)1.48201462
98Increased nuchal translucency (HP:0010880)1.47979015
99Esophageal atresia (HP:0002032)1.47814019
100Inability to walk (HP:0002540)1.47354488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.40670010
2MARK15.38250699
3PNCK3.50887970
4WNK32.54591504
5CAMK1G2.51173532
6NTRK22.29593935
7DYRK22.29457091
8MAP3K42.07263107
9MAPK132.01171123
10EPHA41.95763769
11NTRK31.94081837
12EPHB21.84101085
13SIK21.83816479
14CAMK1D1.78899270
15TNIK1.78595059
16MKNK21.68513849
17MAP2K71.67799311
18FRK1.52427444
19MINK11.49721648
20NTRK11.39835062
21TYRO31.38797176
22BCR1.33049348
23CSNK1G21.24458935
24BMPR1B1.23732440
25PRKD31.13420259
26PRKCG1.13310921
27MKNK11.09093235
28AKT31.08712121
29PHKG11.04390184
30PHKG21.04390184
31CSNK1G11.00238793
32SGK2230.99857605
33SGK4940.99857605
34MAP3K100.98425902
35ICK0.98023835
36EPHA30.96050458
37CSNK1G30.93874444
38MAP2K40.92805841
39CSNK1A1L0.90918107
40INSRR0.90862070
41SGK20.89524143
42FGFR20.87750469
43DYRK1A0.82049438
44PAK30.81519789
45KSR10.79283765
46CDK50.78041971
47ADRBK20.75977455
48WNK40.75802667
49MAP3K90.70566848
50UHMK10.69582675
51DYRK30.67946590
52PRKCZ0.66641853
53CDK190.64743340
54PKN10.64677723
55LATS20.64263842
56ERBB30.63242846
57MAPK150.62268388
58PINK10.61270917
59PRKCE0.60482358
60TRIM280.59893560
61CSNK1E0.59133234
62PRKCH0.58775750
63OXSR10.56729126
64STK390.56712660
65CAMK2A0.56372175
66CDK180.56195805
67CDK150.55837070
68RPS6KA20.55386958
69CDK30.55276195
70CAMK10.54408053
71LATS10.54158001
72GRK10.53755655
73STK110.52123285
74MARK20.51887918
75CDK11A0.50088803
76SGK30.49965442
77CHEK20.48801936
78DAPK20.48346879
79PRKAA10.46461792
80CAMK2B0.46139898
81CDK140.46083534
82PAK60.45660469
83STK38L0.45478263
84PLK20.44758189
85NEK20.43842336
86SGK10.43530708
87RPS6KA40.43154405
88ERBB20.42516664
89CSNK1D0.42369121
90CAMK40.41225730
91GSK3B0.40803770
92EEF2K0.40388582
93MAP4K20.39596582
94MTOR0.38865460
95PRKDC0.38365175
96TSSK60.38259333
97WEE10.37880930
98MAPKAPK50.34758979
99PTK20.32783811
100CDK10.32673982

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79805797
2Axon guidance_Homo sapiens_hsa043602.30975799
3Glutamatergic synapse_Homo sapiens_hsa047242.12837289
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12487111
5GABAergic synapse_Homo sapiens_hsa047272.07684399
6Cocaine addiction_Homo sapiens_hsa050302.05213325
7Dopaminergic synapse_Homo sapiens_hsa047281.96852638
8Morphine addiction_Homo sapiens_hsa050321.93863326
9Circadian entrainment_Homo sapiens_hsa047131.92335006
10Basal cell carcinoma_Homo sapiens_hsa052171.90066354
11Taste transduction_Homo sapiens_hsa047421.81764315
12Hedgehog signaling pathway_Homo sapiens_hsa043401.73998436
13Phototransduction_Homo sapiens_hsa047441.58252724
14Insulin secretion_Homo sapiens_hsa049111.57925099
15Hippo signaling pathway_Homo sapiens_hsa043901.55507368
16Cholinergic synapse_Homo sapiens_hsa047251.54929896
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54674327
18Amphetamine addiction_Homo sapiens_hsa050311.52329351
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48270818
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45811980
21Steroid biosynthesis_Homo sapiens_hsa001001.43636907
22Serotonergic synapse_Homo sapiens_hsa047261.31949337
23Gap junction_Homo sapiens_hsa045401.29251227
24Synaptic vesicle cycle_Homo sapiens_hsa047211.27470205
25Long-term depression_Homo sapiens_hsa047301.22776919
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22645364
27Wnt signaling pathway_Homo sapiens_hsa043101.19766347
28Dorso-ventral axis formation_Homo sapiens_hsa043201.17301889
29Cardiac muscle contraction_Homo sapiens_hsa042601.17031095
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16803473
31Melanogenesis_Homo sapiens_hsa049161.09022071
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08308667
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08292319
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07597585
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06223915
36Fatty acid biosynthesis_Homo sapiens_hsa000611.04646712
37cAMP signaling pathway_Homo sapiens_hsa040241.03467694
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02917185
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99962580
40Dilated cardiomyopathy_Homo sapiens_hsa054140.96919772
41Lysine degradation_Homo sapiens_hsa003100.93988138
42Butanoate metabolism_Homo sapiens_hsa006500.92196268
43Oxytocin signaling pathway_Homo sapiens_hsa049210.91782890
44ErbB signaling pathway_Homo sapiens_hsa040120.90831495
45Salivary secretion_Homo sapiens_hsa049700.89714576
46Gastric acid secretion_Homo sapiens_hsa049710.84794904
47Olfactory transduction_Homo sapiens_hsa047400.84440899
48TGF-beta signaling pathway_Homo sapiens_hsa043500.83842516
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83327928
50Estrogen signaling pathway_Homo sapiens_hsa049150.83114560
51Tight junction_Homo sapiens_hsa045300.82291748
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81756467
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81488288
54Calcium signaling pathway_Homo sapiens_hsa040200.80905915
55Colorectal cancer_Homo sapiens_hsa052100.80079458
56Long-term potentiation_Homo sapiens_hsa047200.79358979
57Renin secretion_Homo sapiens_hsa049240.79322601
58Basal transcription factors_Homo sapiens_hsa030220.78876704
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78380133
60Notch signaling pathway_Homo sapiens_hsa043300.77929725
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77335850
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73810305
63Melanoma_Homo sapiens_hsa052180.73363514
64Endometrial cancer_Homo sapiens_hsa052130.73279250
65Oocyte meiosis_Homo sapiens_hsa041140.72895772
66Protein export_Homo sapiens_hsa030600.72870094
67Thyroid hormone synthesis_Homo sapiens_hsa049180.72818159
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71430821
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69582099
70Alcoholism_Homo sapiens_hsa050340.67767252
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65275122
72Ovarian steroidogenesis_Homo sapiens_hsa049130.64870297
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64577889
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63214211
75MicroRNAs in cancer_Homo sapiens_hsa052060.62425878
76Type II diabetes mellitus_Homo sapiens_hsa049300.61514191
77Selenocompound metabolism_Homo sapiens_hsa004500.60961700
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60402469
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59479966
80mRNA surveillance pathway_Homo sapiens_hsa030150.58960555
81ECM-receptor interaction_Homo sapiens_hsa045120.58448840
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58324518
83Circadian rhythm_Homo sapiens_hsa047100.58069093
84Adherens junction_Homo sapiens_hsa045200.56590371
85Nitrogen metabolism_Homo sapiens_hsa009100.56458018
86Ras signaling pathway_Homo sapiens_hsa040140.55512167
87AMPK signaling pathway_Homo sapiens_hsa041520.53073741
88MAPK signaling pathway_Homo sapiens_hsa040100.52193006
89Fanconi anemia pathway_Homo sapiens_hsa034600.50341013
90Rap1 signaling pathway_Homo sapiens_hsa040150.50222844
91Bile secretion_Homo sapiens_hsa049760.48349324
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46913892
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.46739402
94Glioma_Homo sapiens_hsa052140.46176158
95Huntingtons disease_Homo sapiens_hsa050160.45266227
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44726502
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.44081085
98Pathways in cancer_Homo sapiens_hsa052000.42154432
99Pancreatic secretion_Homo sapiens_hsa049720.41279116
100Fatty acid metabolism_Homo sapiens_hsa012120.40865649

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