KIAA1551

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.69863806
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.56028463
3negative regulation of cell killing (GO:0031342)6.56028463
4regulation of B cell receptor signaling pathway (GO:0050855)6.04235735
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.00558496
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62891794
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.62891794
8modulation by symbiont of host immune response (GO:0052553)5.62891794
9positive regulation by symbiont of host defense response (GO:0052509)5.62891794
10modulation by symbiont of host defense response (GO:0052031)5.62891794
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62891794
12detection of molecule of bacterial origin (GO:0032490)5.39154723
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.29828329
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.06830115
15regulation of gamma-delta T cell differentiation (GO:0045586)4.92797760
16regulation of gamma-delta T cell activation (GO:0046643)4.88720468
17response to interleukin-15 (GO:0070672)4.84588752
18negative T cell selection (GO:0043383)4.83328514
19cellular response to interleukin-15 (GO:0071350)4.66840521
20negative thymic T cell selection (GO:0045060)4.59584676
21microglial cell activation (GO:0001774)4.56948487
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52701817
23macrophage activation involved in immune response (GO:0002281)4.46785484
24detection of external biotic stimulus (GO:0098581)4.35206674
25antigen processing and presentation of endogenous antigen (GO:0019883)4.34378078
26cellular extravasation (GO:0045123)4.33060565
27regulation of interferon-beta biosynthetic process (GO:0045357)4.33003538
28detection of other organism (GO:0098543)4.27978330
29positive T cell selection (GO:0043368)4.21680589
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.17341639
31positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.15602817
32negative regulation of T cell mediated immunity (GO:0002710)4.14599204
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.09116251
34neutrophil activation involved in immune response (GO:0002283)4.01980989
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99123553
36B cell receptor signaling pathway (GO:0050853)3.96796025
37positive thymic T cell selection (GO:0045059)3.92994836
38neutrophil mediated immunity (GO:0002446)3.90922334
39response to host immune response (GO:0052572)3.85806528
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85806528
41detection of biotic stimulus (GO:0009595)3.82082286
42macrophage activation (GO:0042116)3.80988459
43leukocyte aggregation (GO:0070486)3.76477213
44regulation of B cell differentiation (GO:0045577)3.75223623
45activated T cell proliferation (GO:0050798)3.73800308
46negative regulation of interleukin-12 production (GO:0032695)3.66699819
47neutrophil activation (GO:0042119)3.64655307
48detection of bacterium (GO:0016045)3.63180020
49T cell migration (GO:0072678)3.57038499
50myeloid leukocyte mediated immunity (GO:0002444)3.55750345
51dendritic cell migration (GO:0036336)3.53804225
52hepatocyte apoptotic process (GO:0097284)3.53784032
53regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.52875425
54response to host (GO:0075136)3.52196761
55response to host defenses (GO:0052200)3.52196761
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52196761
57T cell selection (GO:0045058)3.52007383
58regulation of alpha-beta T cell proliferation (GO:0046640)3.51704297
59myeloid cell activation involved in immune response (GO:0002275)3.46282259
60respiratory burst (GO:0045730)3.45988740
61negative regulation of leukocyte mediated immunity (GO:0002704)3.44633327
62production of molecular mediator involved in inflammatory response (GO:0002532)3.42282368
63antigen processing and presentation via MHC class Ib (GO:0002475)3.39363863
64positive regulation of granulocyte differentiation (GO:0030854)3.39074590
65positive regulation of B cell differentiation (GO:0045579)3.36805662
66negative regulation of B cell proliferation (GO:0030889)3.36111625
67interferon-gamma production (GO:0032609)3.31798481
68dendritic cell chemotaxis (GO:0002407)3.29266265
69phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.27206846
70negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.26631956
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24935224
72positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24066257
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23507901
74regulation of regulatory T cell differentiation (GO:0045589)3.22505906
75positive regulation of alpha-beta T cell proliferation (GO:0046641)3.20690809
76positive regulation of interferon-alpha production (GO:0032727)3.19214338
77granulocyte activation (GO:0036230)3.18958879
78response to peptidoglycan (GO:0032494)3.18895832
79negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14491861
80thymic T cell selection (GO:0045061)3.13223594
81tolerance induction (GO:0002507)3.07837804
82negative regulation of adaptive immune response (GO:0002820)3.04526458
83histone H3-K36 demethylation (GO:0070544)3.03507045
84mast cell activation (GO:0045576)3.00830032
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00281289
86negative regulation of T-helper cell differentiation (GO:0045623)3.00281289
87leukocyte degranulation (GO:0043299)2.93183522
88regulation of interferon-alpha production (GO:0032647)2.92311983
89regulation of T cell mediated cytotoxicity (GO:0001914)2.91055402
90type I interferon signaling pathway (GO:0060337)2.90469530
91cellular response to type I interferon (GO:0071357)2.90469530
92positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.88675228
93leukocyte migration involved in inflammatory response (GO:0002523)2.88668275
94response to type I interferon (GO:0034340)2.88579985
95regulation of tolerance induction (GO:0002643)2.87669584
96antigen receptor-mediated signaling pathway (GO:0050851)2.86078646
97defense response to protozoan (GO:0042832)2.83214359
98regulation of necroptotic process (GO:0060544)2.82851694
99negative regulation of B cell mediated immunity (GO:0002713)2.79364409
100negative regulation of immunoglobulin mediated immune response (GO:0002890)2.79364409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.01091024
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.12895712
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.08180536
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.82113373
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.50629490
6RUNX_20019798_ChIP-Seq_JUKART_Human3.50398806
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42643965
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14396946
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.03267686
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02942102
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.99763015
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96541166
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.95299241
14MYB_26560356_Chip-Seq_TH2_Human2.88169451
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.82229782
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77693370
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48461315
18SPI1_23547873_ChIP-Seq_NB4_Human2.42734389
19MYB_26560356_Chip-Seq_TH1_Human2.33633905
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30731934
21SCL_19346495_ChIP-Seq_HPC-7_Human2.30583868
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19111962
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16812499
24GATA3_27048872_Chip-Seq_THYMUS_Human2.10741808
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94768139
26SPI1_23127762_ChIP-Seq_K562_Human1.94206206
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91540335
28GATA3_26560356_Chip-Seq_TH2_Human1.80862480
29MAF_26560356_Chip-Seq_TH1_Human1.78106861
30RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.77296135
31VDR_24787735_ChIP-Seq_THP-1_Human1.75049734
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74223754
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72659326
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70088439
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.62965682
36GATA1_22025678_ChIP-Seq_K562_Human1.61055255
37UTX_26944678_Chip-Seq_JUKART_Human1.56320033
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56189582
39PU_27001747_Chip-Seq_BMDM_Mouse1.55423675
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55421207
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.53442606
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51487914
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50899095
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.50204393
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.50139027
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45496057
47VDR_24763502_ChIP-Seq_THP-1_Human1.43138452
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40124738
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.35521382
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28247053
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19451942
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.16348398
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15648969
54TCF7_22412390_ChIP-Seq_EML_Mouse1.14331873
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14182578
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12549232
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11729390
58MYC_22102868_ChIP-Seq_BL_Human1.09708587
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09183925
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.07472668
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05879406
62MAF_26560356_Chip-Seq_TH2_Human1.03489230
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01023772
64SMRT_27268052_Chip-Seq_Bcells_Human1.00916564
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98607934
66PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98472218
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97764397
68FOXO3_23340844_ChIP-Seq_DLD1_Human0.97702921
69EZH2_27294783_Chip-Seq_NPCs_Mouse0.95956333
70GATA2_19941826_ChIP-Seq_K562_Human0.93599497
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91349668
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89953373
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89277123
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88712492
75GATA3_26560356_Chip-Seq_TH1_Human0.88203128
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88182956
77SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87694184
78PRDM14_20953172_ChIP-Seq_ESCs_Human0.85841730
79GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85797928
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85007524
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84670896
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.84339149
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.83594570
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83059282
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82765734
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82543187
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82044410
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81819697
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81052879
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80998327
91VDR_21846776_ChIP-Seq_THP-1_Human0.80464379
92GATA1_19941826_ChIP-Seq_K562_Human0.79876155
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79084677
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78727632
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77727151
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.75053372
97GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74636290
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72111450
99ER_23166858_ChIP-Seq_MCF-7_Human0.70883653
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70810690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.16942215
2MP0001835_abnormal_antigen_presentation3.70835135
3MP0003763_abnormal_thymus_physiology3.28727761
4MP0003436_decreased_susceptibility_to3.25084553
5MP0000569_abnormal_digit_pigmentation3.18293905
6MP0005671_abnormal_response_to3.16637458
7MP0001800_abnormal_humoral_immune3.06921259
8MP0008260_abnormal_autophagy2.79767414
9MP0003303_peritoneal_inflammation2.70861997
10MP0000685_abnormal_immune_system2.62396203
11MP0005000_abnormal_immune_tolerance2.58666943
12MP0002419_abnormal_innate_immunity2.57433926
13MP0002723_abnormal_immune_serum2.52895023
14MP0002420_abnormal_adaptive_immunity2.47358205
15MP0009785_altered_susceptibility_to2.46619402
16MP0001819_abnormal_immune_cell2.44745380
17MP0005025_abnormal_response_to2.41411272
18MP0002452_abnormal_antigen_presenting2.41380336
19MP0004381_abnormal_hair_follicle2.30541710
20MP0005387_immune_system_phenotype2.24332590
21MP0001790_abnormal_immune_system2.24332590
22MP0008057_abnormal_DNA_replication2.20229872
23MP0002398_abnormal_bone_marrow2.17894298
24MP0002166_altered_tumor_susceptibility2.10712586
25MP0003787_abnormal_imprinting2.05157066
26MP0000716_abnormal_immune_system2.01461003
27MP0002396_abnormal_hematopoietic_system2.00837896
28MP0003300_gastrointestinal_ulcer1.98338668
29MP0002405_respiratory_system_inflammati1.94156693
30MP0000465_gastrointestinal_hemorrhage1.93160091
31MP0000703_abnormal_thymus_morphology1.91712019
32MP0003828_pulmonary_edema1.91551676
33MP0000689_abnormal_spleen_morphology1.85743721
34MP0002722_abnormal_immune_system1.81835017
35MP0002148_abnormal_hypersensitivity_rea1.78706965
36MP0005451_abnormal_body_composition1.75562527
37MP0008877_abnormal_DNA_methylation1.74731801
38MP0006082_CNS_inflammation1.72222223
39MP0004883_abnormal_blood_vessel1.70876535
40MP0005464_abnormal_platelet_physiology1.67705823
41MP0005075_abnormal_melanosome_morpholog1.61528451
42MP0003191_abnormal_cellular_cholesterol1.60280768
43MP0003866_abnormal_defecation1.59599291
44MP0002429_abnormal_blood_cell1.59031509
45MP0010155_abnormal_intestine_physiology1.56520705
46MP0003172_abnormal_lysosome_physiology1.56465619
47MP0002009_preneoplasia1.56116649
48MP0001845_abnormal_inflammatory_respons1.55480182
49MP0001533_abnormal_skeleton_physiology1.52834954
50MP0009333_abnormal_splenocyte_physiolog1.50219060
51MP0002277_abnormal_respiratory_mucosa1.49971438
52MP0004947_skin_inflammation1.45969624
53MP0002006_tumorigenesis1.44936527
54MP0003221_abnormal_cardiomyocyte_apopto1.41852808
55MP0002132_abnormal_respiratory_system1.41441133
56MP0003656_abnormal_erythrocyte_physiolo1.40293524
57MP0005310_abnormal_salivary_gland1.37575136
58MP0000015_abnormal_ear_pigmentation1.26904832
59MP0009764_decreased_sensitivity_to1.26167436
60MP0003183_abnormal_peptide_metabolism1.22375433
61MP0000858_altered_metastatic_potential1.20867101
62MP0001851_eye_inflammation1.20475960
63MP0005164_abnormal_response_to1.20073450
64MP0005397_hematopoietic_system_phenotyp1.13987807
65MP0001545_abnormal_hematopoietic_system1.13987807
66MP0009278_abnormal_bone_marrow1.10014949
67MP0006054_spinal_hemorrhage1.08511530
68MP0008469_abnormal_protein_level1.06293364
69MP0004808_abnormal_hematopoietic_stem0.98825997
70MP0005174_abnormal_tail_pigmentation0.98645335
71MP0002998_abnormal_bone_remodeling0.91596593
72MP0003690_abnormal_glial_cell0.91422085
73MP0004484_altered_response_of0.91054720
74MP0003448_altered_tumor_morphology0.88285564
75MP0001853_heart_inflammation0.80977730
76MP0002138_abnormal_hepatobiliary_system0.78408525
77MP0004130_abnormal_muscle_cell0.78113557
78MP0004264_abnormal_extraembryonic_tissu0.77306680
79MP0002019_abnormal_tumor_incidence0.75893548
80MP0009763_increased_sensitivity_to0.70653802
81MP0000604_amyloidosis0.67382384
82MP0000249_abnormal_blood_vessel0.64282899
83MP0002133_abnormal_respiratory_system0.64279674
84MP0005388_respiratory_system_phenotype0.64279674
85MP0002933_joint_inflammation0.61398652
86MP0000371_diluted_coat_color0.61154093
87MP0003252_abnormal_bile_duct0.59886639
88MP0009765_abnormal_xenobiotic_induced0.59224978
89MP0005376_homeostasis/metabolism_phenot0.58417330
90MP0008004_abnormal_stomach_pH0.55627235
91MP0001873_stomach_inflammation0.53745584
92MP0002332_abnormal_exercise_endurance0.53422270
93MP0003091_abnormal_cell_migration0.53355219
94MP0005166_decreased_susceptibility_to0.53337253
95MP0003121_genomic_imprinting0.53095552
96MP0003045_fibrosis0.53085919
97MP0002928_abnormal_bile_duct0.51520572
98MP0005076_abnormal_cell_differentiation0.50798779
99MP0005621_abnormal_cell_physiology0.49117396
100MP0001663_abnormal_digestive_system0.48627857

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.13926929
2Eczematoid dermatitis (HP:0000976)5.86711509
3Abnormality of T cell number (HP:0011839)5.70422213
4Recurrent bacterial skin infections (HP:0005406)5.56573027
5Recurrent abscess formation (HP:0002722)5.17839204
6Retrobulbar optic neuritis (HP:0100654)5.16618560
7Optic neuritis (HP:0100653)5.16618560
8Myositis (HP:0100614)5.02273787
9Orchitis (HP:0100796)5.01636843
10Stomatitis (HP:0010280)4.58377156
11Recurrent fungal infections (HP:0002841)4.50254359
12Gastrointestinal infarctions (HP:0005244)4.39775742
13Abnormality of T cells (HP:0002843)3.95490861
14Keratoconjunctivitis sicca (HP:0001097)3.94458474
15Spontaneous hematomas (HP:0007420)3.93586414
16Elevated erythrocyte sedimentation rate (HP:0003565)3.90460394
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.88583255
18Chronic mucocutaneous candidiasis (HP:0002728)3.87331604
19Recurrent cutaneous fungal infections (HP:0011370)3.87331604
20Recurrent skin infections (HP:0001581)3.83054346
21Recurrent gram-negative bacterial infections (HP:0005420)3.82456582
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.74321204
23Keratoconjunctivitis (HP:0001096)3.67625869
24Encephalitis (HP:0002383)3.66381436
25Mediastinal lymphadenopathy (HP:0100721)3.56158850
26Abnormality of macrophages (HP:0004311)3.52574614
27Meningitis (HP:0001287)3.49797655
28Gingivitis (HP:0000230)3.49073088
29Leukocytosis (HP:0001974)3.39143993
30Vasculitis (HP:0002633)3.32105707
31Recurrent viral infections (HP:0004429)3.26926578
32Chest pain (HP:0100749)3.16604700
33Arterial thrombosis (HP:0004420)3.16263397
34Subacute progressive viral hepatitis (HP:0006572)3.09216978
35Hemoptysis (HP:0002105)3.07978993
36Gingival bleeding (HP:0000225)3.07152948
37Eosinophilia (HP:0001880)2.92730945
38Pulmonary infiltrates (HP:0002113)2.91221556
39Abnormality of eosinophils (HP:0001879)2.89932666
40Obstructive lung disease (HP:0006536)2.88408916
41Chronic obstructive pulmonary disease (HP:0006510)2.88408916
42Recurrent bronchitis (HP:0002837)2.85315698
43Peritonitis (HP:0002586)2.84372181
44Urticaria (HP:0001025)2.83959939
45Autoimmune hemolytic anemia (HP:0001890)2.82758552
46Hypochromic microcytic anemia (HP:0004840)2.81885914
47Granulocytopenia (HP:0001913)2.76711122
48IgG deficiency (HP:0004315)2.70037085
49IgM deficiency (HP:0002850)2.65533542
50Panhypogammaglobulinemia (HP:0003139)2.65440476
51Pulmonary embolism (HP:0002204)2.62453417
52Severe combined immunodeficiency (HP:0004430)2.61547212
53Anorexia (HP:0002039)2.59687727
54Lymphopenia (HP:0001888)2.58932345
55Stomach cancer (HP:0012126)2.57890035
56Viral hepatitis (HP:0006562)2.57260905
57Pustule (HP:0200039)2.54910134
58Thyroiditis (HP:0100646)2.53482049
59Inflammation of the large intestine (HP:0002037)2.52892978
60Abnormality of T cell physiology (HP:0011840)2.52209085
61Cellulitis (HP:0100658)2.49291129
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.45583747
63Epistaxis (HP:0000421)2.39874556
64Osteomyelitis (HP:0002754)2.39329300
65Gangrene (HP:0100758)2.37104750
66Chronic diarrhea (HP:0002028)2.36793891
67Gastrointestinal inflammation (HP:0004386)2.35032737
68Prolonged bleeding time (HP:0003010)2.32921519
69Hypochromic anemia (HP:0001931)2.31188230
70Neoplasm of the tracheobronchial system (HP:0100552)2.26391099
71Increased IgM level (HP:0003496)2.24829670
72Slow saccadic eye movements (HP:0000514)2.24687405
73Increased IgE level (HP:0003212)2.22190262
74Microcytic anemia (HP:0001935)2.22013954
75Sepsis (HP:0100806)2.15993860
76Acute hepatic failure (HP:0006554)2.15087871
77Papillary thyroid carcinoma (HP:0002895)2.14542892
78Colitis (HP:0002583)2.13399850
79Keratitis (HP:0000491)2.13064608
80Abnormality of the peritoneum (HP:0002585)2.11567373
81Combined immunodeficiency (HP:0005387)2.11083841
82Episodic fever (HP:0001954)2.10953785
83Hypoplasia of the thymus (HP:0000778)2.08345266
84Abnormality of the endocardium (HP:0004306)2.04517373
85Abnormality of the pleura (HP:0002103)2.02081223
86Periodontitis (HP:0000704)2.01946027
87Abnormality of the fingertips (HP:0001211)2.01202817
88Papilloma (HP:0012740)2.00918494
89Verrucae (HP:0200043)2.00918494
90Hematochezia (HP:0002573)1.97663097
91IgA deficiency (HP:0002720)1.94857566
92Agammaglobulinemia (HP:0004432)1.94704938
93Amaurosis fugax (HP:0100576)1.94692590
94Abnormality of B cell number (HP:0010975)1.93283917
95Alveolar cell carcinoma (HP:0006519)1.93091267
96Thrombophlebitis (HP:0004418)1.91904149
97Glomerulopathy (HP:0100820)1.84602662
98Lymphoma (HP:0002665)1.83044180
99Autoimmune thrombocytopenia (HP:0001973)1.82315271
100Cheilitis (HP:0100825)1.79543665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.96615203
2MAP4K13.18342889
3TXK2.96952539
4BLK2.96564616
5IRAK42.81620608
6CSK2.70651348
7TAOK32.56158787
8TYK22.52427197
9GRK62.46986495
10FES2.44232717
11MAP3K142.15363164
12IKBKE2.04975765
13MAP2K32.00910499
14JAK31.98117456
15BTK1.94261960
16JAK11.91471333
17FGR1.90283112
18ZAP701.85148155
19SYK1.73692081
20NLK1.71947924
21TEC1.70769566
22YES11.64009862
23HCK1.61107215
24MAP3K21.60898430
25ITK1.54866654
26FGFR31.51661558
27IRAK11.45833270
28JAK21.42153516
29ACVR1B1.40536578
30EPHB11.40256897
31MAP3K131.37019831
32LYN1.36182333
33PIK3CG1.35808278
34BMPR21.31135175
35PRPF4B1.25988871
36LCK1.25084181
37FRK1.12352551
38STK101.09681027
39IRAK21.09410923
40MARK31.08277290
41CAMKK21.05737145
42SIK31.04511245
43MAP3K61.03804200
44MAP3K11.02616422
45MATK1.00814802
46TNK20.99358485
47WNK10.99005586
48KSR20.98628831
49PIM10.97620266
50SGK20.97450759
51MAP3K100.90361742
52FGFR40.88823088
53STK40.87586178
54LRRK20.87316572
55RAF10.82833786
56MARK20.82242475
57CSF1R0.79167327
58SGK30.78283039
59KSR10.78004128
60TGFBR20.77736421
61BRD40.77292966
62KIT0.74894800
63TBK10.72423764
64PRKCQ0.71780619
65CDK190.71756200
66PTK2B0.71650709
67IKBKB0.70465676
68MAP3K30.69101616
69EPHA30.68956486
70NUAK10.68696892
71MAP3K70.67210098
72MAP3K50.65027963
73PDK10.63434662
74ERN10.61033310
75DYRK30.59389420
76NEK60.58479790
77STK110.57527823
78EGFR0.55186936
79TAOK10.54788997
80MELK0.54371114
81CDK60.53743777
82MAP2K40.50532102
83FYN0.49536934
84DYRK1B0.48353767
85CAMK40.48010736
86ERBB20.46582956
87CLK10.46024201
88RET0.45579168
89DYRK1A0.44294973
90STK380.44024980
91CDK40.43966639
92GRK50.43242451
93MST40.42089497
94CDK120.40497981
95CAMKK10.38114497
96MAPK70.37461972
97SGK2230.37286978
98SGK4940.37286978
99PTK60.37097492
100SGK10.37001857

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.79031976
2Primary immunodeficiency_Homo sapiens_hsa053402.67757783
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.58047584
4Osteoclast differentiation_Homo sapiens_hsa043802.56048377
5B cell receptor signaling pathway_Homo sapiens_hsa046622.45827983
6T cell receptor signaling pathway_Homo sapiens_hsa046602.34855876
7Measles_Homo sapiens_hsa051622.21265567
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13332483
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.07441989
10Staphylococcus aureus infection_Homo sapiens_hsa051502.04600083
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01591584
12Graft-versus-host disease_Homo sapiens_hsa053322.00127004
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96205193
14Tuberculosis_Homo sapiens_hsa051521.90188964
15Allograft rejection_Homo sapiens_hsa053301.88557172
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87709162
17Autoimmune thyroid disease_Homo sapiens_hsa053201.85394417
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79915278
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76969784
20Acute myeloid leukemia_Homo sapiens_hsa052211.68537890
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.67675205
22Hematopoietic cell lineage_Homo sapiens_hsa046401.66637589
23Non-small cell lung cancer_Homo sapiens_hsa052231.65510247
24Chemokine signaling pathway_Homo sapiens_hsa040621.59487150
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58558038
26Legionellosis_Homo sapiens_hsa051341.51583284
27Influenza A_Homo sapiens_hsa051641.50327530
28Toxoplasmosis_Homo sapiens_hsa051451.49550248
29Hepatitis B_Homo sapiens_hsa051611.45870964
30Malaria_Homo sapiens_hsa051441.45629049
31Herpes simplex infection_Homo sapiens_hsa051681.44163469
32Antigen processing and presentation_Homo sapiens_hsa046121.35346936
33TNF signaling pathway_Homo sapiens_hsa046681.34081408
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34069457
35Type I diabetes mellitus_Homo sapiens_hsa049401.27405544
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.27286611
37Pancreatic cancer_Homo sapiens_hsa052121.24639510
38Platelet activation_Homo sapiens_hsa046111.20612363
39Dorso-ventral axis formation_Homo sapiens_hsa043201.15461975
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.14839243
41Viral myocarditis_Homo sapiens_hsa054161.14288374
42Hepatitis C_Homo sapiens_hsa051601.13231695
43Prolactin signaling pathway_Homo sapiens_hsa049171.12994505
44FoxO signaling pathway_Homo sapiens_hsa040681.11106331
45Apoptosis_Homo sapiens_hsa042101.10114115
46Chronic myeloid leukemia_Homo sapiens_hsa052201.08438171
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04097054
48Renal cell carcinoma_Homo sapiens_hsa052110.95756846
49Endometrial cancer_Homo sapiens_hsa052130.95309977
50Inositol phosphate metabolism_Homo sapiens_hsa005620.94732736
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91765372
52Viral carcinogenesis_Homo sapiens_hsa052030.89291912
53VEGF signaling pathway_Homo sapiens_hsa043700.85997671
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.85232127
55Colorectal cancer_Homo sapiens_hsa052100.84744685
56mTOR signaling pathway_Homo sapiens_hsa041500.83274522
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83014297
58African trypanosomiasis_Homo sapiens_hsa051430.81541434
59Shigellosis_Homo sapiens_hsa051310.80183894
60Asthma_Homo sapiens_hsa053100.80179351
61Phagosome_Homo sapiens_hsa041450.80167771
62Prostate cancer_Homo sapiens_hsa052150.76694188
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.76124124
64Regulation of autophagy_Homo sapiens_hsa041400.74620761
65Choline metabolism in cancer_Homo sapiens_hsa052310.72133080
66Epstein-Barr virus infection_Homo sapiens_hsa051690.71606331
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70063009
68Thyroid cancer_Homo sapiens_hsa052160.69267330
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67546289
70HIF-1 signaling pathway_Homo sapiens_hsa040660.65552545
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65016802
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64424936
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64046355
74ErbB signaling pathway_Homo sapiens_hsa040120.62733852
75Pertussis_Homo sapiens_hsa051330.61942504
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59436213
77HTLV-I infection_Homo sapiens_hsa051660.57739978
78Endocytosis_Homo sapiens_hsa041440.56938499
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55191676
80Salmonella infection_Homo sapiens_hsa051320.53788410
81Notch signaling pathway_Homo sapiens_hsa043300.53593363
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.52976826
83Insulin resistance_Homo sapiens_hsa049310.52212154
84Glioma_Homo sapiens_hsa052140.51281975
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50340283
86MAPK signaling pathway_Homo sapiens_hsa040100.50053402
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48689931
88GnRH signaling pathway_Homo sapiens_hsa049120.45667696
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.45538776
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43226312
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42571142
92Rheumatoid arthritis_Homo sapiens_hsa053230.42327471
93Rap1 signaling pathway_Homo sapiens_hsa040150.41169560
94MicroRNAs in cancer_Homo sapiens_hsa052060.40609334
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39660592
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39643706
97Small cell lung cancer_Homo sapiens_hsa052220.39281573
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39235464
99Long-term potentiation_Homo sapiens_hsa047200.38787574
100Ras signaling pathway_Homo sapiens_hsa040140.38469697

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