ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.22697038
2	behavioral response to nicotine (GO:0035095)	4.02741933
3	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.80657515
4	membrane depolarization during action potential (GO:0086010)	3.54301350
5	retinal cone cell development (GO:0046549)	3.47518171
6	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.42132687
7	positive regulation of CREB transcription factor activity (GO:0032793)	3.39224905
8	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.34037677
9	startle response (GO:0001964)	3.23157415
10	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.17707974
11	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.16027692
12	postsynaptic membrane organization (GO:0001941)	3.12420182
13	response to pheromone (GO:0019236)	3.03659608
14	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.03368077
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.01870539
16	detection of light stimulus involved in visual perception (GO:0050908)	3.01870539
17	neuronal action potential propagation (GO:0019227)	2.97455687
18	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.96053185
19	proline transport (GO:0015824)	2.95644180
20	regulation of synapse maturation (GO:0090128)	2.95467461
21	neuron cell-cell adhesion (GO:0007158)	2.95098506
22	gamma-aminobutyric acid transport (GO:0015812)	2.92138190
23	glutamate receptor signaling pathway (GO:0007215)	2.89397013
24	L-fucose catabolic process (GO:0042355)	2.88571157
25	fucose catabolic process (GO:0019317)	2.88571157
26	L-fucose metabolic process (GO:0042354)	2.88571157
27	regulation of hippo signaling (GO:0035330)	2.87016334
28	regulation of action potential (GO:0098900)	2.85333135
29	dendritic spine morphogenesis (GO:0060997)	2.82019720
30	urinary tract smooth muscle contraction (GO:0014848)	2.80735073
31	negative regulation of cAMP-mediated signaling (GO:0043951)	2.78446594
32	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.77700736
33	neuromuscular synaptic transmission (GO:0007274)	2.74214074
34	glycosphingolipid biosynthetic process (GO:0006688)	2.70849934
35	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.69891278
36	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.68900901
37	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.67546113
38	regulation of synapse structural plasticity (GO:0051823)	2.64293199
39	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.61755010
40	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.59908535
41	regulation of translation, ncRNA-mediated (GO:0045974)	2.59908535
42	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.59908535
43	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.58841896
44	auditory behavior (GO:0031223)	2.58095646
45	negative regulation of Rho protein signal transduction (GO:0035024)	2.57364059
46	cAMP catabolic process (GO:0006198)	2.55733713
47	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.53930946
48	macroautophagy (GO:0016236)	2.53610278
49	neuronal action potential (GO:0019228)	2.53506069
50	nephron epithelium morphogenesis (GO:0072088)	2.53334690
51	nephron tubule morphogenesis (GO:0072078)	2.53334690
52	vocalization behavior (GO:0071625)	2.53311377
53	synaptic vesicle maturation (GO:0016188)	2.52482239
54	auditory receptor cell stereocilium organization (GO:0060088)	2.51992573
55	synaptic transmission, glutamatergic (GO:0035249)	2.51944655
56	behavioral response to ethanol (GO:0048149)	2.49608360
57	regulation of neurotransmitter uptake (GO:0051580)	2.49430550
58	cyclic nucleotide catabolic process (GO:0009214)	2.48512489
59	membrane depolarization (GO:0051899)	2.44961753
60	sympathetic nervous system development (GO:0048485)	2.43766907
61	cellular response to ATP (GO:0071318)	2.43330442
62	insulin secretion (GO:0030073)	2.42917499
63	photoreceptor cell development (GO:0042461)	2.39979886
64	potassium ion transmembrane transport (GO:0071805)	2.39878314
65	cellular potassium ion transport (GO:0071804)	2.39878314
66	serotonin metabolic process (GO:0042428)	2.39520148
67	regulation of respiratory system process (GO:0044065)	2.38818388
68	primary amino compound metabolic process (GO:1901160)	2.38597523
69	alanine transport (GO:0032328)	2.38524425
70	photoreceptor cell maintenance (GO:0045494)	2.36500056
71	coenzyme catabolic process (GO:0009109)	2.36292539
72	renal tubule morphogenesis (GO:0061333)	2.35583937
73	positive regulation of synapse maturation (GO:0090129)	2.33839986
74	neurotransmitter-gated ion channel clustering (GO:0072578)	2.32984220
75	potassium ion transport (GO:0006813)	2.32239177
76	positive regulation of fatty acid oxidation (GO:0046321)	2.31454926
77	smooth muscle contraction (GO:0006939)	2.31377372
78	inositol phosphate catabolic process (GO:0071545)	2.29441421
79	eye photoreceptor cell development (GO:0042462)	2.29372266
80	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.29291913
81	phosphorelay signal transduction system (GO:0000160)	2.28746492
82	regulation of energy homeostasis (GO:2000505)	2.27950619
83	ovulation cycle (GO:0042698)	2.27585486
84	cornea development in camera-type eye (GO:0061303)	2.27363509
85	positive regulation of catecholamine secretion (GO:0033605)	2.26919826
86	atrial cardiac muscle cell action potential (GO:0086014)	2.26291039
87	protein import into peroxisome matrix (GO:0016558)	2.25753225
88	spinal cord motor neuron differentiation (GO:0021522)	2.23414235
89	cell migration in hindbrain (GO:0021535)	2.22411931
90	dermatan sulfate metabolic process (GO:0030205)	2.20717507
91	regulation of neurotransmitter transport (GO:0051588)	2.18923325
92	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.18766273
93	cellular ketone body metabolic process (GO:0046950)	2.17513822
94	action potential (GO:0001508)	2.17021443
95	reflex (GO:0060004)	2.16760653
96	opioid receptor signaling pathway (GO:0038003)	2.16577656
97	axoneme assembly (GO:0035082)	2.16009432
98	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.15822038
99	positive regulation of action potential (GO:0045760)	2.14574469
100	negative regulation of mast cell activation (GO:0033004)	2.14386441

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.54764563
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.39636297
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.88831767
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42221823
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32064311
6	DROSHA_22980978_ChIP-Seq_HELA_Human	2.04952642
7	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.95391522
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.93809440
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87877625
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87736502
11	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78684065
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.78495077
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78155761
14	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.70655955
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.68101992
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67775408
17	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.66305177
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65863174
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.65602557
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65413049
21	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.65031977
22	VDR_22108803_ChIP-Seq_LS180_Human	1.64120356
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.62179627
24	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.61944530
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57498277
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.56740320
27	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53877055
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53837689
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53837689
30	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53668385
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.52566723
32	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.48289247
33	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.47930102
34	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.47861413
35	* ER_23166858_ChIP-Seq_MCF-7_Human	1.47364958
36	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.46245409
37	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.45593782
38	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.44656111
39	STAT3_23295773_ChIP-Seq_U87_Human	1.41340745
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41235293
41	P300_19829295_ChIP-Seq_ESCs_Human	1.39564022
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37122749
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.36169834
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.36169834
45	TCF4_23295773_ChIP-Seq_U87_Human	1.33911042
46	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31501847
47	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.30443745
48	AR_21572438_ChIP-Seq_LNCaP_Human	1.30364789
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29647401
50	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.28969371
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24175157
52	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.22815566
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22634729
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.21391595
55	AHR_22903824_ChIP-Seq_MCF-7_Human	1.19631460
56	AR_25329375_ChIP-Seq_VCAP_Human	1.17906124
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17595121
58	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16413105
59	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16234933
60	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.13018708
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12758733
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10957977
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10477584
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10397225
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10191054
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.09785572
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09785572
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.09714221
69	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09222094
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07751408
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.07578708
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07294888
73	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06688402
74	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06470325
75	FUS_26573619_Chip-Seq_HEK293_Human	1.05565218
76	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.04417024
77	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.03949909
78	TP53_16413492_ChIP-PET_HCT116_Human	1.02746137
79	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.02222120
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01743675
81	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01123428
82	AR_19668381_ChIP-Seq_PC3_Human	1.00888081
83	RXR_22108803_ChIP-Seq_LS180_Human	1.00643231
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.00606953
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.99762394
86	ERA_21632823_ChIP-Seq_H3396_Human	0.98096568
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97238967
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.97157652
89	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.96250597
90	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.95829036
91	* SMAD3_21741376_ChIP-Seq_ESCs_Human	0.94695354
92	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.94654967
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94614027
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94514476
95	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93809799
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93345478
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93180857
98	* TBL1_22424771_ChIP-Seq_293T_Human	0.92124478
99	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.92007787
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91651200

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001968_abnormal_touch/_nociception	2.63164938
2	MP0004859_abnormal_synaptic_plasticity	2.47705541
3	MP0003195_calcinosis	2.45939078
4	MP0003646_muscle_fatigue	2.43449094
5	MP0005551_abnormal_eye_electrophysiolog	2.30368682
6	MP0010386_abnormal_urinary_bladder	2.29907055
7	MP0009046_muscle_twitch	2.28170737
8	MP0001486_abnormal_startle_reflex	2.24867773
9	MP0005423_abnormal_somatic_nervous	2.20801092
10	MP0004885_abnormal_endolymph	2.12641471
11	MP0002272_abnormal_nervous_system	2.12294436
12	MP0005646_abnormal_pituitary_gland	2.09991024
13	MP0003635_abnormal_synaptic_transmissio	2.07180913
14	MP0003880_abnormal_central_pattern	2.06241514
15	MP0000569_abnormal_digit_pigmentation	2.06196355
16	MP0002638_abnormal_pupillary_reflex	2.05029381
17	MP0001986_abnormal_taste_sensitivity	2.04383961
18	MP0009745_abnormal_behavioral_response	2.03722990
19	MP0002736_abnormal_nociception_after	2.03495436
20	MP0005503_abnormal_tendon_morphology	1.99820860
21	MP0003283_abnormal_digestive_organ	1.94283319
22	MP0001501_abnormal_sleep_pattern	1.87311623
23	MP0002837_dystrophic_cardiac_calcinosis	1.87265195
24	MP0002064_seizures	1.77421124
25	MP0002063_abnormal_learning/memory/cond	1.74943365
26	MP0002572_abnormal_emotion/affect_behav	1.74107450
27	MP0001984_abnormal_olfaction	1.73561224
28	MP0004043_abnormal_pH_regulation	1.71775387
29	MP0005171_absent_coat_pigmentation	1.70405574
30	MP0001502_abnormal_circadian_rhythm	1.70305022
31	MP0002735_abnormal_chemical_nociception	1.66268535
32	MP0003879_abnormal_hair_cell	1.66126739
33	MP0005253_abnormal_eye_physiology	1.63047614
34	MP0001958_emphysema	1.60837194
35	MP0002102_abnormal_ear_morphology	1.60132238
36	MP0006276_abnormal_autonomic_nervous	1.56264012
37	MP0002557_abnormal_social/conspecific_i	1.47467467
38	MP0006072_abnormal_retinal_apoptosis	1.43264283
39	MP0001970_abnormal_pain_threshold	1.41790724
40	MP0005174_abnormal_tail_pigmentation	1.40704469
41	MP0005377_hearing/vestibular/ear_phenot	1.39422382
42	MP0003878_abnormal_ear_physiology	1.39422382
43	MP0005645_abnormal_hypothalamus_physiol	1.37950419
44	MP0003136_yellow_coat_color	1.36722470
45	MP0002734_abnormal_mechanical_nocicepti	1.35401989
46	MP0002822_catalepsy	1.33768499
47	MP0004145_abnormal_muscle_electrophysio	1.32927192
48	MP0001485_abnormal_pinna_reflex	1.32180939
49	MP0002876_abnormal_thyroid_physiology	1.31957178
50	MP0000013_abnormal_adipose_tissue	1.26544473
51	MP0002733_abnormal_thermal_nociception	1.25154918
52	MP0003137_abnormal_impulse_conducting	1.23876888
53	MP0002067_abnormal_sensory_capabilities	1.23721083
54	MP0002108_abnormal_muscle_morphology	1.23129419
55	MP0005386_behavior/neurological_phenoty	1.22499366
56	MP0004924_abnormal_behavior	1.22499366
57	MP0004215_abnormal_myocardial_fiber	1.21314540
58	MP0004130_abnormal_muscle_cell	1.19660135
59	MP0008877_abnormal_DNA_methylation	1.18140616
60	MP0001963_abnormal_hearing_physiology	1.16746481
61	MP0003279_aneurysm	1.14970713
62	MP0000751_myopathy	1.14728804
63	MP0004084_abnormal_cardiac_muscle	1.14388705
64	MP0001756_abnormal_urination	1.13365909
65	MP0009780_abnormal_chondrocyte_physiolo	1.11786251
66	MP0008438_abnormal_cutaneous_collagen	1.11740221
67	MP0004142_abnormal_muscle_tone	1.11069366
68	MP0004085_abnormal_heartbeat	1.10357843
69	MP0000631_abnormal_neuroendocrine_gland	1.04147344
70	MP0004036_abnormal_muscle_relaxation	1.04073981
71	MP0002229_neurodegeneration	1.04002077
72	MP0000538_abnormal_urinary_bladder	1.01795391
73	MP0000427_abnormal_hair_cycle	0.99355690
74	MP0002184_abnormal_innervation	0.97395907
75	MP0000026_abnormal_inner_ear	0.97267604
76	MP0004133_heterotaxia	0.96838118
77	MP0005167_abnormal_blood-brain_barrier	0.95539759
78	MP0001346_abnormal_lacrimal_gland	0.93930135
79	MP0002882_abnormal_neuron_morphology	0.93107628
80	MP0003633_abnormal_nervous_system	0.91757976
81	MP0005195_abnormal_posterior_eye	0.91401630
82	MP0004742_abnormal_vestibular_system	0.91367596
83	MP0003045_fibrosis	0.90619876
84	MP0000015_abnormal_ear_pigmentation	0.90093958
85	MP0002752_abnormal_somatic_nervous	0.89651209
86	MP0002909_abnormal_adrenal_gland	0.87670965
87	MP0000230_abnormal_systemic_arterial	0.87611764
88	MP0003787_abnormal_imprinting	0.86560267
89	MP0001299_abnormal_eye_distance/	0.86063224
90	MP0001324_abnormal_eye_pigmentation	0.85744571
91	MP0000778_abnormal_nervous_system	0.85408075
92	MP0001664_abnormal_digestion	0.85253596
93	MP0001905_abnormal_dopamine_level	0.83886425
94	MP0000372_irregular_coat_pigmentation	0.83250169
95	MP0004270_analgesia	0.82459108
96	MP0002066_abnormal_motor_capabilities/c	0.79022440
97	MP0005187_abnormal_penis_morphology	0.78365219
98	MP0005620_abnormal_muscle_contractility	0.78120971
99	MP0008872_abnormal_physiological_respon	0.75596322
100	MP0004381_abnormal_hair_follicle	0.74533595

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.78605727
2	Genetic anticipation (HP:0003743)	4.32136912
3	Attenuation of retinal blood vessels (HP:0007843)	3.53852468
4	Febrile seizures (HP:0002373)	3.45699770
5	Abnormality of midbrain morphology (HP:0002418)	3.40217640
6	Molar tooth sign on MRI (HP:0002419)	3.40217640
7	Progressive cerebellar ataxia (HP:0002073)	3.17672391
8	Protruding tongue (HP:0010808)	3.16037987
9	Hyperventilation (HP:0002883)	3.01508076
10	Gaze-evoked nystagmus (HP:0000640)	3.00798395
11	Type II lissencephaly (HP:0007260)	2.99315759
12	Pancreatic cysts (HP:0001737)	2.96236662
13	Focal seizures (HP:0007359)	2.88131961
14	Nephronophthisis (HP:0000090)	2.85995332
15	Cerebellar dysplasia (HP:0007033)	2.75601720
16	Atonic seizures (HP:0010819)	2.73569972
17	Keratoconus (HP:0000563)	2.72544535
18	Increased corneal curvature (HP:0100692)	2.72544535
19	Polydipsia (HP:0001959)	2.72277061
20	Abnormal drinking behavior (HP:0030082)	2.72277061
21	Chronic hepatic failure (HP:0100626)	2.64252802
22	Decreased central vision (HP:0007663)	2.63503790
23	Clumsiness (HP:0002312)	2.63482866
24	Tubular atrophy (HP:0000092)	2.58783629
25	Abnormality of the renal cortex (HP:0011035)	2.55305391
26	Congenital sensorineural hearing impairment (HP:0008527)	2.50997158
27	Abnormality of the renal medulla (HP:0100957)	2.45935201
28	Intestinal atresia (HP:0011100)	2.45508203
29	Epileptic encephalopathy (HP:0200134)	2.44182301
30	Cystic liver disease (HP:0006706)	2.43472540
31	Prolonged QT interval (HP:0001657)	2.43283031
32	Bony spicule pigmentary retinopathy (HP:0007737)	2.40139741
33	Absent speech (HP:0001344)	2.40056288
34	Flat cornea (HP:0007720)	2.34338969
35	Bulbous nose (HP:0000414)	2.33307921
36	Focal motor seizures (HP:0011153)	2.33177356
37	Pancreatic fibrosis (HP:0100732)	2.32332055
38	True hermaphroditism (HP:0010459)	2.31353483
39	Arthropathy (HP:0003040)	2.29698819
40	Hypoplastic ischia (HP:0003175)	2.28079043
41	Progressive inability to walk (HP:0002505)	2.27314813
42	Abolished electroretinogram (ERG) (HP:0000550)	2.22761867
43	Inability to walk (HP:0002540)	2.19588139
44	Dialeptic seizures (HP:0011146)	2.13269850
45	Absence seizures (HP:0002121)	2.10194147
46	Broad-based gait (HP:0002136)	2.08159441
47	Morphological abnormality of the middle ear (HP:0008609)	2.05445520
48	Hypothermia (HP:0002045)	2.04853337
49	Hemiparesis (HP:0001269)	2.04074647
50	Fetal akinesia sequence (HP:0001989)	2.01390283
51	Supernumerary spleens (HP:0009799)	1.99945238
52	Polyuria (HP:0000103)	1.97363400
53	Anterior segment dysgenesis (HP:0007700)	1.97292216
54	Renovascular hypertension (HP:0100817)	1.96241007
55	Abnormality of the ischium (HP:0003174)	1.94842586
56	Abnormal rod and cone electroretinograms (HP:0008323)	1.93072194
57	Short chin (HP:0000331)	1.92957626
58	Lissencephaly (HP:0001339)	1.92657017
59	Atrial fibrillation (HP:0005110)	1.90725572
60	Facial diplegia (HP:0001349)	1.87233006
61	Aortic aneurysm (HP:0004942)	1.86433117
62	Obstructive sleep apnea (HP:0002870)	1.86373046
63	Epileptiform EEG discharges (HP:0011182)	1.85235815
64	Annular pancreas (HP:0001734)	1.84888267
65	Retinal dysplasia (HP:0007973)	1.82454916
66	Abnormal EKG (HP:0003115)	1.80326109
67	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.80103152
68	Pachygyria (HP:0001302)	1.79883918
69	EEG with generalized epileptiform discharges (HP:0011198)	1.79309551
70	Primary atrial arrhythmia (HP:0001692)	1.79212196
71	Chorioretinal atrophy (HP:0000533)	1.79043050
72	Wrist flexion contracture (HP:0001239)	1.78396228
73	Bowel diverticulosis (HP:0005222)	1.77948013
74	Constricted visual fields (HP:0001133)	1.77710229
75	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.76605207
76	Hypoplasia of the fovea (HP:0007750)	1.76605207
77	Urinary bladder sphincter dysfunction (HP:0002839)	1.74854934
78	Amblyopia (HP:0000646)	1.74354557
79	Central scotoma (HP:0000603)	1.74278123
80	Depressed nasal tip (HP:0000437)	1.73659489
81	Macroglossia (HP:0000158)	1.73582797
82	Decreased circulating renin level (HP:0003351)	1.73103231
83	Medial flaring of the eyebrow (HP:0010747)	1.72858282
84	Congenital hepatic fibrosis (HP:0002612)	1.72623166
85	Hypoventilation (HP:0002791)	1.71203691
86	Action tremor (HP:0002345)	1.70040173
87	Bradycardia (HP:0001662)	1.68703264
88	Small hand (HP:0200055)	1.68162674
89	Optic nerve hypoplasia (HP:0000609)	1.67945280
90	Posterior subcapsular cataract (HP:0007787)	1.67187296
91	Type II diabetes mellitus (HP:0005978)	1.66610136
92	Pendular nystagmus (HP:0012043)	1.65686394
93	Abnormality of the right ventricle (HP:0001707)	1.65393332
94	Abnormal eating behavior (HP:0100738)	1.64923382
95	Large for gestational age (HP:0001520)	1.64500469
96	Infantile muscular hypotonia (HP:0008947)	1.63715207
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.62479351
98	Bladder diverticulum (HP:0000015)	1.62312372
99	Hypsarrhythmia (HP:0002521)	1.61163091
100	Renal cortical cysts (HP:0000803)	1.61077593

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.67278858
2	PINK1	3.93294476
3	ADRBK2	3.12365282
4	INSRR	2.93170253
5	DAPK2	2.43956066
6	BMPR1B	2.11478560
7	GRK1	2.02081246
8	MARK1	2.02045058
9	TLK1	1.84252288
10	MAP3K7	1.83730352
11	CASK	1.81245474
12	MUSK	1.80623598
13	MAPK13	1.78830538
14	NTRK3	1.73893260
15	ACVR1B	1.69097443
16	AKT3	1.68025988
17	PRKD3	1.60701786
18	WNK4	1.54353760
19	SIK2	1.49084922
20	WNK3	1.45035785
21	MYLK	1.39906543
22	ZAK	1.38575465
23	ADRBK1	1.33989544
24	NTRK2	1.33446211
25	TAOK3	1.31387274
26	NUAK1	1.20875938
27	PAK3	1.19018746
28	PRKD2	1.17842803
29	PAK6	1.17308355
30	PRKCH	1.14998659
31	CAMK1	1.11045837
32	CAMK1D	1.03809063
33	SGK494	1.00100368
34	SGK223	1.00100368
35	PRKCE	1.00015367
36	FGFR2	0.99788278
37	SGK2	0.98213146
38	PRKCG	0.97372952
39	STK38	0.97030192
40	OBSCN	0.94337254
41	MAP4K2	0.93087335
42	CAMKK1	0.90820593
43	PRKAA1	0.90336950
44	PHKG2	0.89101451
45	PHKG1	0.89101451
46	CDC42BPA	0.85038575
47	NEK2	0.83928697
48	TNIK	0.83633885
49	EPHA3	0.83473705
50	PKN1	0.82873987
51	MARK2	0.82025056
52	CAMKK2	0.80967062
53	CAMK4	0.78135556
54	WNK1	0.77092501
55	PTK2B	0.75873804
56	ROCK1	0.75843879
57	OXSR1	0.75524271
58	CAMK2A	0.74036670
59	STK11	0.72475075
60	MARK3	0.72274712
61	PRKAA2	0.70165556
62	MAPK15	0.70117035
63	KIT	0.69073833
64	TXK	0.67892407
65	MAPK12	0.63216544
66	DDR2	0.62107327
67	TNK2	0.61139580
68	UHMK1	0.60521094
69	NLK	0.59223122
70	LATS1	0.58770265
71	MKNK2	0.57082444
72	TIE1	0.55720653
73	MAP3K4	0.55552866
74	CSNK1A1L	0.55279879
75	CHUK	0.54289537
76	PLK2	0.53601117
77	PRKCZ	0.53020562
78	STK39	0.52330462
79	CSNK1G1	0.51925239
80	MAP2K6	0.50607063
81	TGFBR1	0.47660615
82	HIPK2	0.47503077
83	CAMK2B	0.46500685
84	CAMK1G	0.46134058
85	RPS6KA6	0.44734483
86	CDK5	0.43937207
87	EPHA4	0.43414549
88	PRKG1	0.42865472
89	CSNK1G2	0.42591144
90	RPS6KA2	0.40946655
91	PRKACA	0.40848255
92	CSNK1G3	0.37368851
93	SGK3	0.37136552
94	MAP2K7	0.36680429
95	TRPM7	0.35454932
96	TYRO3	0.34168653
97	CDK3	0.33967395
98	RPS6KA3	0.32176053
99	CAMK2D	0.32001190
100	CSNK1D	0.31917159

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.17428915
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.99347336
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.83783275
4	Phototransduction_Homo sapiens_hsa04744	2.42050191
5	Taste transduction_Homo sapiens_hsa04742	2.33246232
6	Morphine addiction_Homo sapiens_hsa05032	2.28547530
7	Circadian entrainment_Homo sapiens_hsa04713	2.20482078
8	Insulin secretion_Homo sapiens_hsa04911	2.18376078
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.15810571
10	Glutamatergic synapse_Homo sapiens_hsa04724	2.14165613
11	GABAergic synapse_Homo sapiens_hsa04727	2.02657877
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.92256372
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.87074391
14	Olfactory transduction_Homo sapiens_hsa04740	1.86627661
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.63765748
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59355936
17	Butanoate metabolism_Homo sapiens_hsa00650	1.57957215
18	Circadian rhythm_Homo sapiens_hsa04710	1.53612584
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.52244503
20	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.51929065
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.50316109
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46486920
23	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.43409662
24	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.42234776
25	Amphetamine addiction_Homo sapiens_hsa05031	1.40202906
26	Gastric acid secretion_Homo sapiens_hsa04971	1.39404996
27	Dopaminergic synapse_Homo sapiens_hsa04728	1.35865492
28	ABC transporters_Homo sapiens_hsa02010	1.35105840
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34318814
30	cAMP signaling pathway_Homo sapiens_hsa04024	1.34023515
31	Cholinergic synapse_Homo sapiens_hsa04725	1.31945513
32	Cocaine addiction_Homo sapiens_hsa05030	1.31769180
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.26708855
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.25777636
35	Salivary secretion_Homo sapiens_hsa04970	1.22756085
36	Serotonergic synapse_Homo sapiens_hsa04726	1.21339176
37	Type II diabetes mellitus_Homo sapiens_hsa04930	1.10893512
38	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.10725170
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.07980435
40	Renin secretion_Homo sapiens_hsa04924	1.04284440
41	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.03645686
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.02238077
43	Lysine degradation_Homo sapiens_hsa00310	0.95246755
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93814856
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.93504435
46	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.93140880
47	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.91860332
48	Long-term depression_Homo sapiens_hsa04730	0.91174347
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.89763219
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85151051
51	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.83816806
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.82736831
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81781459
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.79706660
55	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.79434129
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78034328
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.77677130
58	Long-term potentiation_Homo sapiens_hsa04720	0.77116594
59	ECM-receptor interaction_Homo sapiens_hsa04512	0.73010813
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.69959370
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.69038404
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65190859
63	Axon guidance_Homo sapiens_hsa04360	0.62905014
64	Melanogenesis_Homo sapiens_hsa04916	0.61391716
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.58714713
66	Ras signaling pathway_Homo sapiens_hsa04014	0.58518358
67	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.57229837
68	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.55759203
69	Protein digestion and absorption_Homo sapiens_hsa04974	0.54974144
70	Propanoate metabolism_Homo sapiens_hsa00640	0.52761301
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51363014
72	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.50225704
73	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.48872051
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47985314
75	Melanoma_Homo sapiens_hsa05218	0.47128482
76	Bile secretion_Homo sapiens_hsa04976	0.46077970
77	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.45760194
78	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.45662363
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44758103
80	GnRH signaling pathway_Homo sapiens_hsa04912	0.44231960
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.43584413
82	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43530458
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.43524529
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.43515955
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.43477873
86	mTOR signaling pathway_Homo sapiens_hsa04150	0.42861713
87	Basal transcription factors_Homo sapiens_hsa03022	0.42002554
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40261147
89	Insulin resistance_Homo sapiens_hsa04931	0.39868850
90	Mineral absorption_Homo sapiens_hsa04978	0.39732994
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39343927
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36890681
93	Pancreatic secretion_Homo sapiens_hsa04972	0.36670386
94	FoxO signaling pathway_Homo sapiens_hsa04068	0.35990719
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.35843759
96	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.34532169
97	Estrogen signaling pathway_Homo sapiens_hsa04915	0.32282182
98	Focal adhesion_Homo sapiens_hsa04510	0.31891798
99	AMPK signaling pathway_Homo sapiens_hsa04152	0.31745210
100	Alcoholism_Homo sapiens_hsa05034	0.30841235

KIAA1614

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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