ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	desmosome organization (GO:0002934)	6.45796882
2	bundle of His cell to Purkinje myocyte communication (GO:0086069)	6.00460511
3	hemidesmosome assembly (GO:0031581)	5.21804872
4	establishment of skin barrier (GO:0061436)	3.96647171
5	multicellular organismal water homeostasis (GO:0050891)	3.96223254
6	regulation of water loss via skin (GO:0033561)	3.95825834
7	exogenous drug catabolic process (GO:0042738)	3.72183388
8	axonemal dynein complex assembly (GO:0070286)	3.69337276
9	negative regulation of keratinocyte proliferation (GO:0010839)	3.48182403
10	primary alcohol catabolic process (GO:0034310)	3.47998985
11	ethanol metabolic process (GO:0006067)	3.40066429
12	drug catabolic process (GO:0042737)	3.39955443
13	epoxygenase P450 pathway (GO:0019373)	3.37772069
14	vitamin transmembrane transport (GO:0035461)	3.36898611
15	cilium or flagellum-dependent cell motility (GO:0001539)	3.36570160
16	water homeostasis (GO:0030104)	3.34940742
17	ethanol oxidation (GO:0006069)	3.22433513
18	cellular glucuronidation (GO:0052695)	3.19851205
19	gap junction assembly (GO:0016264)	3.18606357
20	flavonoid metabolic process (GO:0009812)	3.14304668
21	regulation of transforming growth factor beta2 production (GO:0032909)	3.13808989
22	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.02022097
23	keratinocyte proliferation (GO:0043616)	3.01998706
24	regulation of cholesterol homeostasis (GO:2000188)	3.01808429
25	intestinal epithelial cell development (GO:0060576)	2.96505504
26	glucuronate metabolic process (GO:0019585)	2.92102772
27	uronic acid metabolic process (GO:0006063)	2.92102772
28	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.90821417
29	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.86038313
30	L-phenylalanine metabolic process (GO:0006558)	2.86038313
31	motile cilium assembly (GO:0044458)	2.84591019
32	regulation of keratinocyte proliferation (GO:0010837)	2.83852876
33	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.82779829
34	cell-substrate junction assembly (GO:0007044)	2.82504984
35	epithelial cell-cell adhesion (GO:0090136)	2.79224966
36	regulation of protein activation cascade (GO:2000257)	2.76328052
37	ventricular cardiac muscle cell action potential (GO:0086005)	2.75867289
38	notochord development (GO:0030903)	2.75002339
39	regulation of complement activation (GO:0030449)	2.73507068
40	surfactant homeostasis (GO:0043129)	2.73288403
41	chemical homeostasis within a tissue (GO:0048875)	2.72648760
42	drug transmembrane transport (GO:0006855)	2.68765269
43	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.67129159
44	L-phenylalanine catabolic process (GO:0006559)	2.67129159
45	drug metabolic process (GO:0017144)	2.61153217
46	intestinal absorption (GO:0050892)	2.60711154
47	cilium movement (GO:0003341)	2.58984523
48	sodium ion homeostasis (GO:0055078)	2.58937914
49	apical protein localization (GO:0045176)	2.58460637
50	urea metabolic process (GO:0019627)	2.58032908
51	biotin metabolic process (GO:0006768)	2.57678348
52	quaternary ammonium group transport (GO:0015697)	2.57152136
53	keratinization (GO:0031424)	2.56195716
54	cell communication involved in cardiac conduction (GO:0086065)	2.51781758
55	renal filtration (GO:0097205)	2.51354158
56	phosphate ion transmembrane transport (GO:0035435)	2.50054702
57	glomerular epithelial cell development (GO:0072310)	2.49951287
58	amino-acid betaine transport (GO:0015838)	2.49429948
59	carnitine transport (GO:0015879)	2.49429948
60	carnitine transmembrane transport (GO:1902603)	2.48577770
61	lung epithelium development (GO:0060428)	2.47253489
62	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.47048350
63	plasma membrane repair (GO:0001778)	2.46795478
64	regulation of bile acid biosynthetic process (GO:0070857)	2.46143298
65	carnitine shuttle (GO:0006853)	2.44653627
66	paraxial mesoderm development (GO:0048339)	2.40984063
67	hippo signaling (GO:0035329)	2.39439371
68	cell-cell junction assembly (GO:0007043)	2.38751314
69	urea cycle (GO:0000050)	2.38324753
70	sphingoid metabolic process (GO:0046519)	2.37913911
71	diol metabolic process (GO:0034311)	2.35299527
72	tight junction assembly (GO:0070830)	2.34731031
73	sphingosine metabolic process (GO:0006670)	2.34157633
74	intestinal cholesterol absorption (GO:0030299)	2.31363923
75	negative regulation of fatty acid transport (GO:2000192)	2.30925736
76	amino-acid betaine metabolic process (GO:0006577)	2.30652712
77	regulation of transforming growth factor beta1 production (GO:0032908)	2.30323113
78	keratinocyte differentiation (GO:0030216)	2.27378885
79	negative regulation of lipase activity (GO:0060192)	2.27355622
80	regulation of transforming growth factor beta production (GO:0071634)	2.26918303
81	O-glycan processing (GO:0016266)	2.26006796
82	bile acid metabolic process (GO:0008206)	2.25628790
83	diterpenoid biosynthetic process (GO:0016102)	2.25486515
84	nitrogen cycle metabolic process (GO:0071941)	2.24054159
85	iron ion import (GO:0097286)	2.23743121
86	asymmetric protein localization (GO:0008105)	2.23444366
87	establishment of apical/basal cell polarity (GO:0035089)	2.23100445
88	negative regulation of protein activation cascade (GO:2000258)	2.22975767
89	regulation of heart rate by cardiac conduction (GO:0086091)	2.22585810
90	omega-hydroxylase P450 pathway (GO:0097267)	2.21977236
91	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.21744718
92	primary alcohol metabolic process (GO:0034308)	2.20853187
93	establishment of planar polarity (GO:0001736)	2.19640813
94	establishment of tissue polarity (GO:0007164)	2.19640813
95	protein carboxylation (GO:0018214)	2.18916850
96	peptidyl-glutamic acid carboxylation (GO:0017187)	2.18916850
97	regulation of endothelial cell chemotaxis (GO:2001026)	2.18694671
98	macroautophagy (GO:0016236)	2.17511711
99	glomerular filtration (GO:0003094)	2.16467424
100	renal system process involved in regulation of blood volume (GO:0001977)	2.16054666

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	5.66265312
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.49165749
3	ESR2_21235772_ChIP-Seq_MCF-7_Human	3.08523513
4	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.81149144
5	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.56608085
6	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.56199747
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.53176114
8	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.53008958
9	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.34938721
10	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.33844880
11	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.25235379
12	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.06923160
13	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.04886931
14	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.91439909
15	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.91273014
16	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.89691919
17	* FOXO3_23340844_ChIP-Seq_DLD1_Human	1.86493167
18	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.86295327
19	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.85814336
20	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.84832323
21	AHR_22903824_ChIP-Seq_MCF-7_Human	1.84759599
22	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.82649751
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.81696754
24	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.80862889
25	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.76000566
26	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.69496641
27	GATA4_25053715_ChIP-Seq_YYC3_Human	1.63248269
28	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.61928674
29	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.60747974
30	ZNF263_19887448_ChIP-Seq_K562_Human	1.58339106
31	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.58121372
32	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.58121372
33	SOX2_20726797_ChIP-Seq_SW620_Human	1.55824895
34	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.53477700
35	GATA6_25053715_ChIP-Seq_YYC3_Human	1.52466703
36	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.51240224
37	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.51126134
38	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.49981337
39	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.48013931
40	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.44502456
41	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.43539749
42	DROSHA_22980978_ChIP-Seq_HELA_Human	1.42640634
43	* TP63_23658742_ChIP-Seq_EP156T_Human	1.41397409
44	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.40796364
45	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36790522
46	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.36409030
47	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.35800375
48	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.35373542
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33815005
50	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.32504392
51	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.32504392
52	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.32109339
53	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.31833058
54	KLF5_25053715_ChIP-Seq_YYC3_Human	1.31615099
55	AR_21572438_ChIP-Seq_LNCaP_Human	1.30821923
56	CLOCK_20551151_ChIP-Seq_293T_Human	1.28765254
57	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.26434760
58	* SMAD3_21741376_ChIP-Seq_HESCs_Human	1.25254408
59	* CJUN_26792858_Chip-Seq_BT549_Human	1.25050715
60	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19894995
61	RACK7_27058665_Chip-Seq_MCF-7_Human	1.17483605
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.15946622
63	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.15416643
64	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.14219684
65	AR_21909140_ChIP-Seq_LNCAP_Human	1.11689343
66	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.11382294
67	RXR_22108803_ChIP-Seq_LS180_Human	1.11239706
68	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10593956
69	* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10399096
70	TP53_16413492_ChIP-PET_HCT116_Human	1.09882366
71	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.09287906
72	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.05410147
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04031875
74	TP63_22573176_ChIP-Seq_HFKS_Human	1.02757875
75	TP53_18474530_ChIP-ChIP_U2OS_Human	1.02498441
76	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.00820443
77	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96228398
78	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.95833134
79	* SMAD4_21741376_ChIP-Seq_HESCs_Human	0.95061448
80	CDX2_22108803_ChIP-Seq_LS180_Human	0.93708232
81	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.93361688
82	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.91479095
83	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.86959244
84	SMC4_20622854_ChIP-Seq_HELA_Human	0.86628732
85	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.85770416
86	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83892445
87	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.83650250
88	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.83167977
89	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.82016871
90	AR_19668381_ChIP-Seq_PC3_Human	0.81679032
91	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.80953817
92	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.80650135
93	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.79689963
94	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.79527957
95	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.78320320
96	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.77535369
97	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.76252452
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.75504852
99	CTCF_27219007_Chip-Seq_Bcells_Human	0.74770635
100	* SMAD4_21799915_ChIP-Seq_A2780_Human	0.74625525

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	4.33797717
2	MP0000566_synostosis	3.27743175
3	MP0009780_abnormal_chondrocyte_physiolo	3.05532031
4	MP0000579_abnormal_nail_morphology	3.00225991
5	MP0002796_impaired_skin_barrier	2.98521639
6	MP0005360_urolithiasis	2.84237724
7	MP0010368_abnormal_lymphatic_system	2.79192627
8	MP0010678_abnormal_skin_adnexa	2.65961579
9	MP0003941_abnormal_skin_development	2.53291576
10	MP0005085_abnormal_gallbladder_physiolo	2.48603061
11	MP0010352_gastrointestinal_tract_polyps	2.47112631
12	MP0000383_abnormal_hair_follicle	2.42731875
13	MP0005365_abnormal_bile_salt	2.42615826
14	MP0004264_abnormal_extraembryonic_tissu	2.41404532
15	MP0008875_abnormal_xenobiotic_pharmacok	2.40651990
16	MP0005409_darkened_coat_color	2.38146217
17	MP0003705_abnormal_hypodermis_morpholog	2.36471020
18	MP0002139_abnormal_hepatobiliary_system	2.34184343
19	MP0001666_abnormal_nutrient_absorption	2.02986582
20	MP0002098_abnormal_vibrissa_morphology	2.01196871
21	MP0004272_abnormal_basement_membrane	1.97757853
22	MP0003566_abnormal_cell_adhesion	1.95375712
23	MP0003045_fibrosis	1.83566574
24	MP0004043_abnormal_pH_regulation	1.75601618
25	MP0003950_abnormal_plasma_membrane	1.71094638
26	MP0000762_abnormal_tongue_morphology	1.68339403
27	MP0003453_abnormal_keratinocyte_physiol	1.66188127
28	MP0005501_abnormal_skin_physiology	1.61807825
29	MP0004233_abnormal_muscle_weight	1.61745393
30	MP0000467_abnormal_esophagus_morphology	1.59956499
31	MP0004782_abnormal_surfactant_physiolog	1.57908235
32	MP0003868_abnormal_feces_composition	1.57476734
33	MP0005670_abnormal_white_adipose	1.55846053
34	MP0003879_abnormal_hair_cell	1.53589818
35	MP0002168_other_aberrant_phenotype	1.44424983
36	MP0005275_abnormal_skin_tensile	1.38323797
37	MP0001216_abnormal_epidermal_layer	1.36703442
38	MP0002876_abnormal_thyroid_physiology	1.36051403
39	MP0000537_abnormal_urethra_morphology	1.35334595
40	MP0005076_abnormal_cell_differentiation	1.35096274
41	MP0003252_abnormal_bile_duct	1.32874073
42	MP0002138_abnormal_hepatobiliary_system	1.32736550
43	MP0003890_abnormal_embryonic-extraembry	1.30703123
44	MP0010030_abnormal_orbit_morphology	1.29583216
45	MP0005023_abnormal_wound_healing	1.28913994
46	MP0000377_abnormal_hair_follicle	1.28186166
47	MP0006138_congestive_heart_failure	1.27146484
48	MP0004019_abnormal_vitamin_homeostasis	1.26909762
49	MP0000751_myopathy	1.19556862
50	MP0003646_muscle_fatigue	1.17744809
51	MP0002060_abnormal_skin_morphology	1.17649387
52	MP0001849_ear_inflammation	1.12832103
53	MP0010329_abnormal_lipoprotein_level	1.09173267
54	MP0000749_muscle_degeneration	1.07536422
55	MP0000678_abnormal_parathyroid_gland	1.07261684
56	MP0001879_abnormal_lymphatic_vessel	1.06590185
57	MP0004858_abnormal_nervous_system	1.04145168
58	MP0010771_integument_phenotype	1.00508149
59	MP0005330_cardiomyopathy	1.00131784
60	MP0001661_extended_life_span	0.96986992
61	MP0005395_other_phenotype	0.96780162
62	MP0002249_abnormal_larynx_morphology	0.96204644
63	MP0000427_abnormal_hair_cycle	0.93168318
64	MP0001765_abnormal_ion_homeostasis	0.90952461
65	MP0005451_abnormal_body_composition	0.90194831
66	MP0004036_abnormal_muscle_relaxation	0.89068230
67	MP0002269_muscular_atrophy	0.88813904
68	MP0005666_abnormal_adipose_tissue	0.88055039
69	MP0002896_abnormal_bone_mineralization	0.87644075
70	MP0000003_abnormal_adipose_tissue	0.87575491
71	MP0000013_abnormal_adipose_tissue	0.86384402
72	MP0004084_abnormal_cardiac_muscle	0.83432132
73	MP0000733_abnormal_muscle_development	0.82509174
74	MP0004087_abnormal_muscle_fiber	0.82166836
75	MP0005375_adipose_tissue_phenotype	0.79039358
76	MP0003195_calcinosis	0.76150601
77	MP0000627_abnormal_mammary_gland	0.74605280
78	MP0002234_abnormal_pharynx_morphology	0.73348782
79	MP0002653_abnormal_ependyma_morphology	0.73288989
80	MP0002971_abnormal_brown_adipose	0.73169605
81	MP0002108_abnormal_muscle_morphology	0.73164864
82	MP0009643_abnormal_urine_homeostasis	0.69812944
83	MP0004484_altered_response_of	0.68799838
84	MP0001984_abnormal_olfaction	0.67709779
85	MP0000747_muscle_weakness	0.65638056
86	MP0005623_abnormal_meninges_morphology	0.65454345
87	MP0005332_abnormal_amino_acid	0.65011350
88	MP0002089_abnormal_postnatal_growth/wei	0.64968745
89	MP0002697_abnormal_eye_size	0.64925077
90	MP0010630_abnormal_cardiac_muscle	0.64459353
91	MP0002118_abnormal_lipid_homeostasis	0.64391842
92	MP0002837_dystrophic_cardiac_calcinosis	0.63127415
93	MP0001299_abnormal_eye_distance/	0.61088310
94	MP0004270_analgesia	0.60886710
95	MP0004185_abnormal_adipocyte_glucose	0.59742360
96	MP0003091_abnormal_cell_migration	0.59724867
97	MP0004381_abnormal_hair_follicle	0.59152522
98	MP0005620_abnormal_muscle_contractility	0.58114146
99	MP0000462_abnormal_digestive_system	0.57907042
100	MP0000432_abnormal_head_morphology	0.57807438

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Right ventricular cardiomyopathy (HP:0011663)	5.52113285
2	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.11802927
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.91214265
4	Hyperactive renin-angiotensin system (HP:0000841)	3.76930292
5	Flat acetabular roof (HP:0003180)	3.54677025
6	Chronic bronchitis (HP:0004469)	3.36479728
7	Hyperkalemia (HP:0002153)	3.35130720
8	Popliteal pterygium (HP:0009756)	3.28385464
9	Lip pit (HP:0100267)	3.24078155
10	Abnormal respiratory motile cilium physiology (HP:0012261)	3.13232183
11	Rhinitis (HP:0012384)	3.09042802
12	Vascular calcification (HP:0004934)	3.05989553
13	Milia (HP:0001056)	3.04065542
14	Abnormal ciliary motility (HP:0012262)	3.01126808
15	Abnormal respiratory motile cilium morphology (HP:0005938)	2.94547955
16	Abnormal respiratory epithelium morphology (HP:0012253)	2.94547955
17	Plantar hyperkeratosis (HP:0007556)	2.90190070
18	Pili torti (HP:0003777)	2.87517067
19	Decreased circulating renin level (HP:0003351)	2.73644328
20	Alopecia of scalp (HP:0002293)	2.73090549
21	Absent/shortened dynein arms (HP:0200106)	2.67140826
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.67140826
23	Bronchomalacia (HP:0002780)	2.63340882
24	Cardiovascular calcification (HP:0011915)	2.63131254
25	Fragile nails (HP:0001808)	2.62981376
26	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.60656178
27	Abnormality of nail color (HP:0100643)	2.58362565
28	Deep venous thrombosis (HP:0002625)	2.53280006
29	Amelogenesis imperfecta (HP:0000705)	2.49537670
30	Pterygium (HP:0001059)	2.48084236
31	Palmoplantar hyperkeratosis (HP:0000972)	2.45021822
32	Abnormality of permanent molar morphology (HP:0011071)	2.43039686
33	Abnormality of the dental root (HP:0006486)	2.43039686
34	Taurodontia (HP:0000679)	2.43039686
35	Hypoplasia of dental enamel (HP:0006297)	2.41994435
36	Advanced eruption of teeth (HP:0006288)	2.41850178
37	Exercise-induced myalgia (HP:0003738)	2.39469430
38	Onycholysis (HP:0001806)	2.39157211
39	Conjugated hyperbilirubinemia (HP:0002908)	2.36838513
40	Hyperaldosteronism (HP:0000859)	2.35312413
41	Thick nail (HP:0001805)	2.32871137
42	Bronchiectasis (HP:0002110)	2.30799790
43	Abnormality of the nasal septum (HP:0000419)	2.30288911
44	Intrahepatic cholestasis (HP:0001406)	2.27740775
45	Hypotrichosis (HP:0001006)	2.26551423
46	Abnormality of the dental pulp (HP:0006479)	2.25488072
47	Palmar hyperkeratosis (HP:0010765)	2.24487161
48	Abnormal hair laboratory examination (HP:0003328)	2.22639622
49	Hyporeflexia of lower limbs (HP:0002600)	2.21782849
50	Hypoplastic labia majora (HP:0000059)	2.21719576
51	Complement deficiency (HP:0004431)	2.21440279
52	Abnormality of the salivary glands (HP:0010286)	2.20106341
53	Abnormality of molar morphology (HP:0011070)	2.18922254
54	Abnormality of molar (HP:0011077)	2.18922254
55	Abnormality of renin-angiotensin system (HP:0000847)	2.17066944
56	Fat malabsorption (HP:0002630)	2.13268479
57	Abnormality of the labia majora (HP:0012881)	2.10434727
58	Hydroxyprolinuria (HP:0003080)	2.10408339
59	Abnormality of proline metabolism (HP:0010907)	2.10408339
60	Hypobetalipoproteinemia (HP:0003563)	2.09181717
61	Ventricular tachycardia (HP:0004756)	2.02996534
62	Vertebral arch anomaly (HP:0008438)	2.00616859
63	Neonatal death (HP:0003811)	1.99301197
64	Dysmetric saccades (HP:0000641)	1.97520998
65	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.96022790
66	Broad face (HP:0000283)	1.93664281
67	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.92915500
68	Abnormality of potassium homeostasis (HP:0011042)	1.92148274
69	Esophageal varix (HP:0002040)	1.90019682
70	Natal tooth (HP:0000695)	1.89973187
71	Bifid scrotum (HP:0000048)	1.89633754
72	Malnutrition (HP:0004395)	1.89329460
73	Obstructive sleep apnea (HP:0002870)	1.89001421
74	Abnormality of chloride homeostasis (HP:0011422)	1.88809703
75	Woolly hair (HP:0002224)	1.87385311
76	Atrophic scars (HP:0001075)	1.87318245
77	Laryngomalacia (HP:0001601)	1.83785551
78	Distal lower limb muscle weakness (HP:0009053)	1.79999546
79	Aplasia involving bones of the extremities (HP:0009825)	1.78173739
80	Aplasia involving bones of the upper limbs (HP:0009823)	1.78173739
81	Aplasia of the phalanges of the hand (HP:0009802)	1.78173739
82	Corneal erosion (HP:0200020)	1.76973114
83	Focal segmental glomerulosclerosis (HP:0000097)	1.76050052
84	Ankyloglossia (HP:0010296)	1.75061606
85	Oligodontia (HP:0000677)	1.74985115
86	Absent eyelashes (HP:0000561)	1.74571516
87	Abnormality of complement system (HP:0005339)	1.73510107
88	Abnormality of carpal bone ossification (HP:0006257)	1.69268402
89	Mitral stenosis (HP:0001718)	1.66616435
90	Nail dystrophy (HP:0008404)	1.66482302
91	Abnormality of secondary sexual hair (HP:0009888)	1.65914153
92	Abnormality of the axillary hair (HP:0100134)	1.65914153
93	Syncope (HP:0001279)	1.65122935
94	Abnormality of the nasal mucosa (HP:0000433)	1.64510658
95	Bundle branch block (HP:0011710)	1.64382107
96	Prolonged partial thromboplastin time (HP:0003645)	1.63059858
97	Spinal cord compression (HP:0002176)	1.60666407
98	Hypercholesterolemia (HP:0003124)	1.60329936
99	Abnormality of the distal phalanges of the toes (HP:0010182)	1.58724429
100	Abnormality of the gastric mucosa (HP:0004295)	1.58530639

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	5.24192988
2	MST1R	4.63580177
3	LATS1	4.39075221
4	RIPK1	3.21400273
5	MET	2.98019931
6	LATS2	2.62560072
7	EEF2K	2.56796475
8	STK38L	2.39606153
9	CDK12	2.32048826
10	TRIB3	2.09427343
11	ICK	2.05044275
12	MAP3K2	2.02401996
13	TIE1	1.79200667
14	MAPKAPK3	1.77802521
15	MAPK15	1.77216678
16	FER	1.73749841
17	OBSCN	1.68930378
18	LMTK2	1.66258292
19	CAMK1D	1.60429426
20	PTK2	1.50270279
21	STK39	1.49959841
22	CAMK1G	1.44071039
23	PRKD3	1.43448204
24	FGFR4	1.42327229
25	SMG1	1.38892029
26	STK38	1.34775708
27	PRKAA2	1.34637816
28	PHKG1	1.32530426
29	PHKG2	1.32530426
30	PIK3CA	1.32220471
31	TRPM7	1.28445759
32	TTN	1.27276336
33	AKT3	1.23121733
34	ACVR1B	1.17326180
35	NLK	1.13977613
36	MELK	1.12823052
37	STK24	1.12647425
38	FRK	1.08907532
39	MAP3K9	1.05077788
40	NTRK1	1.03853516
41	SIK1	1.01925051
42	STK3	0.99374923
43	MTOR	0.98024377
44	MAP3K7	0.97850124
45	FGFR3	0.92809605
46	MST4	0.92175716
47	EPHA4	0.91188581
48	PDGFRA	0.90923856
49	ERN1	0.82483751
50	NEK6	0.80021475
51	EPHB1	0.78071746
52	TGFBR1	0.73180313
53	EPHB2	0.72318804
54	SGK3	0.67920853
55	NME1	0.66778758
56	PDPK1	0.64028037
57	ERBB2	0.62279580
58	FGFR2	0.61660994
59	MAP3K13	0.60609801
60	PDGFRB	0.59822362
61	PRKAA1	0.59248729
62	PTK6	0.58802159
63	CDC42BPA	0.57441121
64	BMPR1B	0.56744483
65	PKN2	0.56253599
66	MAP3K3	0.53747339
67	MAP3K12	0.53651023
68	DMPK	0.53326545
69	FGFR1	0.52327092
70	RET	0.51117797
71	SGK2	0.50886811
72	MAPK11	0.49249187
73	SGK494	0.48538087
74	SGK223	0.48538087
75	TGFBR2	0.48217893
76	PAK4	0.47746039
77	OXSR1	0.46698026
78	MARK2	0.45625151
79	BCR	0.43107846
80	EPHA3	0.42281205
81	PRKG2	0.41870319
82	MAP2K2	0.40249448
83	WNK4	0.36353905
84	MAP2K1	0.36243971
85	ERBB4	0.35940984
86	KSR2	0.35603831
87	RPS6KB2	0.35218133
88	PRKCI	0.34680056
89	AKT2	0.33498026
90	CDK9	0.32838667
91	WNK1	0.32368572
92	MAP2K6	0.32180186
93	RPS6KB1	0.31411427
94	SGK1	0.31407188
95	PRKCE	0.31162656
96	BMX	0.29329687
97	BRSK2	0.27871473
98	CAMK2G	0.26959404
99	MAPKAPK5	0.26380591
100	MAPK10	0.25648761

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	2.99480059
2	Phenylalanine metabolism_Homo sapiens_hsa00360	2.67848453
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.64188851
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.43031783
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.35384929
6	Caffeine metabolism_Homo sapiens_hsa00232	2.16244044
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.15905291
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.11684329
9	Retinol metabolism_Homo sapiens_hsa00830	2.03112290
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.99240222
11	Chemical carcinogenesis_Homo sapiens_hsa05204	1.96413724
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.93264874
13	Bile secretion_Homo sapiens_hsa04976	1.87487174
14	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.73581936
15	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.72413743
16	Tyrosine metabolism_Homo sapiens_hsa00350	1.71175175
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.69895408
18	Fatty acid degradation_Homo sapiens_hsa00071	1.69747102
19	Complement and coagulation cascades_Homo sapiens_hsa04610	1.57943733
20	Adherens junction_Homo sapiens_hsa04520	1.57055611
21	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.46290424
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.41168670
23	ABC transporters_Homo sapiens_hsa02010	1.37212429
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.37160214
25	ECM-receptor interaction_Homo sapiens_hsa04512	1.35130454
26	Circadian rhythm_Homo sapiens_hsa04710	1.34360293
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32776822
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.31792795
29	Tight junction_Homo sapiens_hsa04530	1.30890442
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30789911
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.24781630
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.23111652
33	PPAR signaling pathway_Homo sapiens_hsa03320	1.22740219
34	Sphingolipid metabolism_Homo sapiens_hsa00600	1.22693667
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.17564087
36	Lysine degradation_Homo sapiens_hsa00310	1.17044692
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15845661
38	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.15466224
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.02196344
40	Mineral absorption_Homo sapiens_hsa04978	0.97245768
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.96832196
42	Glucagon signaling pathway_Homo sapiens_hsa04922	0.92925136
43	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.90621402
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89522993
45	Protein digestion and absorption_Homo sapiens_hsa04974	0.87942726
46	Thyroid cancer_Homo sapiens_hsa05216	0.85434423
47	Insulin resistance_Homo sapiens_hsa04931	0.84623132
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84474194
49	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.84229742
50	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.82811956
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.82298848
52	Butanoate metabolism_Homo sapiens_hsa00650	0.80685528
53	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.80600102
54	Pancreatic secretion_Homo sapiens_hsa04972	0.80287230
55	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79711465
56	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79415850
57	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76800531
58	Focal adhesion_Homo sapiens_hsa04510	0.74797642
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74494722
60	Hippo signaling pathway_Homo sapiens_hsa04390	0.70699995
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.70473486
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.69724622
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.69435896
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.68380475
65	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.68095284
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67148329
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.64850971
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63392805
69	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.63024402
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.62946704
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59781720
72	Renin-angiotensin system_Homo sapiens_hsa04614	0.58917942
73	AMPK signaling pathway_Homo sapiens_hsa04152	0.58458536
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58392746
75	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.56796040
76	Insulin signaling pathway_Homo sapiens_hsa04910	0.56622665
77	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.56101445
78	Notch signaling pathway_Homo sapiens_hsa04330	0.54885661
79	Renin secretion_Homo sapiens_hsa04924	0.54590029
80	Sulfur metabolism_Homo sapiens_hsa00920	0.49878147
81	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.49688643
82	Gastric acid secretion_Homo sapiens_hsa04971	0.47765783
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46640800
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46150596
85	Amoebiasis_Homo sapiens_hsa05146	0.45646110
86	Peroxisome_Homo sapiens_hsa04146	0.44767196
87	Salivary secretion_Homo sapiens_hsa04970	0.44407025
88	Choline metabolism in cancer_Homo sapiens_hsa05231	0.44405640
89	Small cell lung cancer_Homo sapiens_hsa05222	0.44016859
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43351153
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43223643
92	Proteoglycans in cancer_Homo sapiens_hsa05205	0.42022078
93	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.40213595
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.40139145
95	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.39214464
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38681564
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37887690
98	Insulin secretion_Homo sapiens_hsa04911	0.36367513
99	Propanoate metabolism_Homo sapiens_hsa00640	0.36268459
100	GnRH signaling pathway_Homo sapiens_hsa04912	0.35771767

KIAA1671

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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