ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H3-K4 trimethylation (GO:0080182)	4.71091571
2	positive regulation of protein kinase C signaling (GO:0090037)	4.30208000
3	cilium or flagellum-dependent cell motility (GO:0001539)	4.10359685
4	behavioral response to nicotine (GO:0035095)	4.00891501
5	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.87185670
6	regulation of translation, ncRNA-mediated (GO:0045974)	3.87185670
7	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.87185670
8	urinary tract smooth muscle contraction (GO:0014848)	3.68010309
9	axoneme assembly (GO:0035082)	3.66809336
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.60524861
11	detection of light stimulus involved in sensory perception (GO:0050962)	3.49443433
12	detection of light stimulus involved in visual perception (GO:0050908)	3.49443433
13	nephron tubule morphogenesis (GO:0072078)	3.39187761
14	nephron epithelium morphogenesis (GO:0072088)	3.39187761
15	positive regulation of CREB transcription factor activity (GO:0032793)	3.21843657
16	establishment of protein localization to Golgi (GO:0072600)	3.12496541
17	cilium movement (GO:0003341)	3.05783695
18	epithelial cilium movement (GO:0003351)	3.05192047
19	peptidyl-lysine trimethylation (GO:0018023)	2.99148708
20	regulation of cilium movement (GO:0003352)	2.96877114
21	axonemal dynein complex assembly (GO:0070286)	2.90700094
22	histone H3-K4 methylation (GO:0051568)	2.81006884
23	peptidyl-lysine methylation (GO:0018022)	2.80016425
24	regulation of microtubule-based movement (GO:0060632)	2.78061084
25	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.75908096
26	interkinetic nuclear migration (GO:0022027)	2.72291320
27	positive regulation of histone deacetylation (GO:0031065)	2.70781884
28	negative regulation of telomere maintenance (GO:0032205)	2.69855966
29	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.69837063
30	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.64646360
31	regulation of synapse structural plasticity (GO:0051823)	2.63559874
32	sperm motility (GO:0030317)	2.62788307
33	protein targeting to Golgi (GO:0000042)	2.61685167
34	mitotic cell cycle arrest (GO:0071850)	2.59364974
35	sex determination (GO:0007530)	2.58659795
36	protein localization to Golgi apparatus (GO:0034067)	2.58347095
37	renal tubule morphogenesis (GO:0061333)	2.57844773
38	histone H3-K9 modification (GO:0061647)	2.57612792
39	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.57509558
40	histone H3-K9 methylation (GO:0051567)	2.57071468
41	protein polyglutamylation (GO:0018095)	2.56540367
42	L-fucose catabolic process (GO:0042355)	2.55901202
43	fucose catabolic process (GO:0019317)	2.55901202
44	L-fucose metabolic process (GO:0042354)	2.55901202
45	glycerophospholipid catabolic process (GO:0046475)	2.55470577
46	cellular response to ATP (GO:0071318)	2.54762919
47	cAMP catabolic process (GO:0006198)	2.51700986
48	spinal cord motor neuron differentiation (GO:0021522)	2.48929742
49	negative regulation of Rho protein signal transduction (GO:0035024)	2.46367967
50	macroautophagy (GO:0016236)	2.46118242
51	cellular response to exogenous dsRNA (GO:0071360)	2.45580748
52	RNA destabilization (GO:0050779)	2.44275491
53	activated T cell proliferation (GO:0050798)	2.43749116
54	regulation of protein kinase C signaling (GO:0090036)	2.42486382
55	dendritic spine morphogenesis (GO:0060997)	2.42221658
56	alanine transport (GO:0032328)	2.41924165
57	membrane depolarization during action potential (GO:0086010)	2.40545635
58	indole-containing compound catabolic process (GO:0042436)	2.40446587
59	indolalkylamine catabolic process (GO:0046218)	2.40446587
60	tryptophan catabolic process (GO:0006569)	2.40446587
61	alkaloid metabolic process (GO:0009820)	2.39634684
62	multicellular organism reproduction (GO:0032504)	2.39334051
63	neuron maturation (GO:0042551)	2.38294513
64	protein K11-linked deubiquitination (GO:0035871)	2.38245535
65	reflex (GO:0060004)	2.36043512
66	motile cilium assembly (GO:0044458)	2.35393858
67	drug catabolic process (GO:0042737)	2.32891229
68	positive regulation of defense response to virus by host (GO:0002230)	2.32231329
69	positive regulation of fatty acid oxidation (GO:0046321)	2.31619050
70	auditory behavior (GO:0031223)	2.31129059
71	negative regulation of interleukin-8 production (GO:0032717)	2.30764026
72	urogenital system development (GO:0001655)	2.29507574
73	response to pheromone (GO:0019236)	2.28941274
74	positive regulation of Rab GTPase activity (GO:0032851)	2.28347960
75	regulation of Rab GTPase activity (GO:0032313)	2.28347960
76	regulation of telomere maintenance (GO:0032204)	2.26179875
77	histone lysine methylation (GO:0034968)	2.25948606
78	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.25888498
79	protein localization to cilium (GO:0061512)	2.25657345
80	cilium organization (GO:0044782)	2.24696229
81	negative regulation of cAMP-mediated signaling (GO:0043951)	2.24271896
82	head development (GO:0060322)	2.23161396
83	startle response (GO:0001964)	2.22821051
84	phosphatidylglycerol biosynthetic process (GO:0006655)	2.22665382
85	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.21254232
86	cyclic nucleotide catabolic process (GO:0009214)	2.20654080
87	cilium assembly (GO:0042384)	2.19750886
88	embryonic hemopoiesis (GO:0035162)	2.19708774
89	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.18899388
90	indolalkylamine metabolic process (GO:0006586)	2.18854906
91	phosphatidylethanolamine metabolic process (GO:0046337)	2.18614239
92	sulfation (GO:0051923)	2.17515627
93	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.16606017
94	positive regulation by host of viral transcription (GO:0043923)	2.16211681
95	regulation of action potential (GO:0098900)	2.13791479
96	regulation of hydrogen peroxide metabolic process (GO:0010310)	2.13644572
97	cilium morphogenesis (GO:0060271)	2.13251731
98	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.12384374
99	positive regulation of protein deacetylation (GO:0090312)	2.12068395
100	regulation of skeletal muscle contraction (GO:0014819)	2.11094388

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.36118526
2	DROSHA_22980978_ChIP-Seq_HELA_Human	3.29295330
3	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.28192366
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.07804202
5	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.04688662
6	VDR_22108803_ChIP-Seq_LS180_Human	1.80041262
7	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75117875
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74348215
9	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.73633526
10	GBX2_23144817_ChIP-Seq_PC3_Human	1.71274829
11	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.70603352
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.69715594
13	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.66724011
14	AR_21572438_ChIP-Seq_LNCaP_Human	1.57909212
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.56592290
16	ERA_21632823_ChIP-Seq_H3396_Human	1.52045381
17	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.51315008
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.41110699
19	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.41064913
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.38531690
21	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.36324877
22	P68_20966046_ChIP-Seq_HELA_Human	1.35958625
23	* CTCF_27219007_Chip-Seq_Bcells_Human	1.35630923
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35515026
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35515026
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.29920807
27	* E2F1_20622854_ChIP-Seq_HELA_Human	1.29219077
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27718310
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26465321
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.26307072
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.22190590
32	PHF8_20622854_ChIP-Seq_HELA_Human	1.22083681
33	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21522641
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20670814
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.19872333
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19694382
37	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19072426
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.18693589
39	OCT4_19829295_ChIP-Seq_ESCs_Human	1.18382707
40	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17569383
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16316176
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.16111415
43	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12184268
44	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.11657252
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11609730
46	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.11415064
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10847794
48	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10204642
49	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09489270
50	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.06248006
51	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06082316
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05990943
53	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.05626426
54	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04852918
55	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04197372
56	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.04117049
57	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.03695801
58	* BCL6_27268052_Chip-Seq_Bcells_Human	1.03545566
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02854978
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.02804616
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02695003
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02313767
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02181422
64	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.01850332
65	* BCOR_27268052_Chip-Seq_Bcells_Human	0.99746955
66	AHR_22903824_ChIP-Seq_MCF-7_Human	0.99349082
67	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.99198541
68	SMC4_20622854_ChIP-Seq_HELA_Human	0.98888198
69	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.98885105
70	* STAT3_23295773_ChIP-Seq_U87_Human	0.98431291
71	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.98177281
72	* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.97686890
73	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.97489230
74	TCF4_23295773_ChIP-Seq_U87_Human	0.97048597
75	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96640860
76	TP53_22573176_ChIP-Seq_HFKS_Human	0.96088251
77	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96032577
78	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95824014
79	P300_27268052_Chip-Seq_Bcells_Human	0.95823444
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.95126042
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.94295303
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94295303
83	* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92198058
84	BCAT_22108803_ChIP-Seq_LS180_Human	0.91907744
85	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.91485056
86	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90089505
87	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.89945635
88	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89901140
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.89850371
90	KDM2B_26808549_Chip-Seq_DND41_Human	0.89169619
91	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.87719807
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.87649466
93	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.86888737
94	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.86888737
95	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.86349210
96	CREB1_26743006_Chip-Seq_LNCaP_Human	0.86133309
97	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.85912347
98	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.85666149
99	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85360020
100	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.85106823

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.76914676
2	MP0002822_catalepsy	3.03121296
3	MP0005377_hearing/vestibular/ear_phenot	2.56398769
4	MP0003878_abnormal_ear_physiology	2.56398769
5	MP0001188_hyperpigmentation	2.41749958
6	MP0001986_abnormal_taste_sensitivity	2.39709716
7	MP0001502_abnormal_circadian_rhythm	2.35847336
8	MP0004043_abnormal_pH_regulation	2.19269190
9	MP0001968_abnormal_touch/_nociception	2.15518291
10	MP0005174_abnormal_tail_pigmentation	2.13336249
11	MP0005551_abnormal_eye_electrophysiolog	2.13090072
12	MP0001501_abnormal_sleep_pattern	2.12909724
13	MP0004381_abnormal_hair_follicle	2.08491720
14	MP0002653_abnormal_ependyma_morphology	2.06682333
15	MP0005646_abnormal_pituitary_gland	1.93675879
16	MP0002928_abnormal_bile_duct	1.86752947
17	MP0002876_abnormal_thyroid_physiology	1.80094829
18	MP0003195_calcinosis	1.79343311
19	MP0008995_early_reproductive_senescence	1.77081247
20	MP0002735_abnormal_chemical_nociception	1.66658414
21	MP0008961_abnormal_basal_metabolism	1.62525408
22	MP0008875_abnormal_xenobiotic_pharmacok	1.60820085
23	MP0002638_abnormal_pupillary_reflex	1.60290202
24	MP0005409_darkened_coat_color	1.60290068
25	MP0005423_abnormal_somatic_nervous	1.57354330
26	MP0005645_abnormal_hypothalamus_physiol	1.53796705
27	MP0003787_abnormal_imprinting	1.52594234
28	MP0004133_heterotaxia	1.52244701
29	MP0006292_abnormal_olfactory_placode	1.51636316
30	MP0009745_abnormal_behavioral_response	1.45545972
31	MP0005670_abnormal_white_adipose	1.44439126
32	MP0001970_abnormal_pain_threshold	1.41800348
33	MP0001485_abnormal_pinna_reflex	1.41067659
34	MP0001486_abnormal_startle_reflex	1.40897967
35	MP0002557_abnormal_social/conspecific_i	1.37570349
36	MP0005410_abnormal_fertilization	1.37199817
37	MP0002572_abnormal_emotion/affect_behav	1.36955097
38	MP0005448_abnormal_energy_balance	1.34994197
39	MP0006276_abnormal_autonomic_nervous	1.33979071
40	MP0002249_abnormal_larynx_morphology	1.33299494
41	MP0003879_abnormal_hair_cell	1.32734115
42	MP0003045_fibrosis	1.27343878
43	MP0000631_abnormal_neuroendocrine_gland	1.27013064
44	MP0004130_abnormal_muscle_cell	1.23331175
45	MP0002733_abnormal_thermal_nociception	1.23196048
46	MP0002063_abnormal_learning/memory/cond	1.22174358
47	MP0003635_abnormal_synaptic_transmissio	1.22047257
48	MP0003646_muscle_fatigue	1.17512320
49	MP0003880_abnormal_central_pattern	1.15201838
50	MP0002064_seizures	1.15074278
51	MP0002272_abnormal_nervous_system	1.14435414
52	MP0000015_abnormal_ear_pigmentation	1.11742100
53	MP0008872_abnormal_physiological_respon	1.11104226
54	MP0002138_abnormal_hepatobiliary_system	1.10998666
55	MP0000026_abnormal_inner_ear	1.10388681
56	MP0002933_joint_inflammation	1.09377564
57	MP0004142_abnormal_muscle_tone	1.08421236
58	MP0004885_abnormal_endolymph	1.07398652
59	MP0004145_abnormal_muscle_electrophysio	1.07299540
60	MP0009046_muscle_twitch	1.07014210
61	MP0001765_abnormal_ion_homeostasis	1.05528057
62	MP0004742_abnormal_vestibular_system	1.04144524
63	MP0003011_delayed_dark_adaptation	1.03738104
64	MP0005167_abnormal_blood-brain_barrier	1.03203876
65	MP0003172_abnormal_lysosome_physiology	0.99603841
66	MP0000470_abnormal_stomach_morphology	0.99232620
67	MP0008877_abnormal_DNA_methylation	0.97587890
68	MP0001873_stomach_inflammation	0.97067069
69	MP0000230_abnormal_systemic_arterial	0.96818846
70	MP0000778_abnormal_nervous_system	0.95268286
71	MP0005253_abnormal_eye_physiology	0.94902686
72	MP0003283_abnormal_digestive_organ	0.94124255
73	MP0001348_abnormal_lacrimal_gland	0.93614390
74	MP0002693_abnormal_pancreas_physiology	0.92105217
75	MP0002909_abnormal_adrenal_gland	0.91575727
76	MP0005310_abnormal_salivary_gland	0.90760732
77	MP0001944_abnormal_pancreas_morphology	0.90242911
78	MP0005083_abnormal_biliary_tract	0.89107187
79	MP0002102_abnormal_ear_morphology	0.88299327
80	MP0004924_abnormal_behavior	0.87657853
81	MP0005386_behavior/neurological_phenoty	0.87657853
82	MP0001963_abnormal_hearing_physiology	0.87409236
83	MP0002736_abnormal_nociception_after	0.87235562
84	MP0005535_abnormal_body_temperature	0.83328578
85	MP0002254_reproductive_system_inflammat	0.81644249
86	MP0002734_abnormal_mechanical_nocicepti	0.81303642
87	MP0001919_abnormal_reproductive_system	0.81043313
88	MP0000013_abnormal_adipose_tissue	0.80138699
89	MP0002067_abnormal_sensory_capabilities	0.79941400
90	MP0001756_abnormal_urination	0.78063085
91	MP0003698_abnormal_male_reproductive	0.77279655
92	MP0002229_neurodegeneration	0.76384634
93	MP0002752_abnormal_somatic_nervous	0.75224891
94	MP0002277_abnormal_respiratory_mucosa	0.73674258
95	MP0005595_abnormal_vascular_smooth	0.71700121
96	MP0005075_abnormal_melanosome_morpholog	0.70633997
97	MP0004859_abnormal_synaptic_plasticity	0.69216852
98	MP0002882_abnormal_neuron_morphology	0.67667381
99	MP0002837_dystrophic_cardiac_calcinosis	0.67431841
100	MP0005195_abnormal_posterior_eye	0.67095486

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	5.09939433
2	Congenital stationary night blindness (HP:0007642)	4.70721002
3	Chronic hepatic failure (HP:0100626)	4.22300073
4	Progressive cerebellar ataxia (HP:0002073)	3.92546671
5	Attenuation of retinal blood vessels (HP:0007843)	3.72763774
6	Nephronophthisis (HP:0000090)	3.69000601
7	Molar tooth sign on MRI (HP:0002419)	3.52812836
8	Abnormality of midbrain morphology (HP:0002418)	3.52812836
9	Decreased circulating renin level (HP:0003351)	3.45781583
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.43062364
11	Abnormality of the renal medulla (HP:0100957)	3.21705982
12	Pancreatic cysts (HP:0001737)	3.15238739
13	Hyperventilation (HP:0002883)	3.13406827
14	Decreased central vision (HP:0007663)	3.02365827
15	Absent/shortened dynein arms (HP:0200106)	3.01225014
16	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.01225014
17	Polydipsia (HP:0001959)	2.95826030
18	Abnormal drinking behavior (HP:0030082)	2.95826030
19	Pancreatic fibrosis (HP:0100732)	2.89911943
20	True hermaphroditism (HP:0010459)	2.85409576
21	Cystic liver disease (HP:0006706)	2.85263162
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.72637937
23	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.72413134
24	Obstructive sleep apnea (HP:0002870)	2.66416966
25	Type II lissencephaly (HP:0007260)	2.63222942
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.62987969
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.62987969
28	Large for gestational age (HP:0001520)	2.62844572
29	Severe visual impairment (HP:0001141)	2.56837749
30	Rib fusion (HP:0000902)	2.53564029
31	Protruding tongue (HP:0010808)	2.51246752
32	Clumsiness (HP:0002312)	2.50620042
33	Hyperkalemia (HP:0002153)	2.49843337
34	Abnormality of the fingertips (HP:0001211)	2.49676429
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49520568
36	Neoplasm of the heart (HP:0100544)	2.45855872
37	Tubular atrophy (HP:0000092)	2.42370153
38	Hypoplastic ischia (HP:0003175)	2.38499081
39	Abnormality of the aortic arch (HP:0012303)	2.36566788
40	Stomach cancer (HP:0012126)	2.26059063
41	Congenital hepatic fibrosis (HP:0002612)	2.25873831
42	Abnormality of the renal cortex (HP:0011035)	2.25190193
43	Cerebellar dysplasia (HP:0007033)	2.24047493
44	Abnormality of renin-angiotensin system (HP:0000847)	2.18010709
45	Patellar aplasia (HP:0006443)	2.17970484
46	Gaze-evoked nystagmus (HP:0000640)	2.17693732
47	Medial flaring of the eyebrow (HP:0010747)	2.17231739
48	Abnormal ciliary motility (HP:0012262)	2.15037859
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.14661451
50	Broad-based gait (HP:0002136)	2.14096497
51	Absent speech (HP:0001344)	2.11623016
52	Polyuria (HP:0000103)	2.09689618
53	Pigmentary retinal degeneration (HP:0001146)	2.08706074
54	Sleep apnea (HP:0010535)	2.07872954
55	Bulbous nose (HP:0000414)	2.05131594
56	Mesangial abnormality (HP:0001966)	2.01364555
57	Tachypnea (HP:0002789)	2.01351149
58	Abnormal respiratory motile cilium physiology (HP:0012261)	1.99632197
59	Truncal obesity (HP:0001956)	1.98853188
60	Widely spaced teeth (HP:0000687)	1.97816823
61	Aplasia/Hypoplasia of the patella (HP:0006498)	1.96455438
62	Agitation (HP:0000713)	1.94043635
63	Hypoplastic nipples (HP:0002557)	1.92751330
64	Tubulointerstitial nephritis (HP:0001970)	1.92506705
65	Abnormality of the ischium (HP:0003174)	1.92043390
66	Testicular atrophy (HP:0000029)	1.89776081
67	Prolonged QT interval (HP:0001657)	1.89459638
68	Abnormality of the pubic bones (HP:0003172)	1.86698560
69	Tented upper lip vermilion (HP:0010804)	1.82942353
70	Macular degeneration (HP:0000608)	1.82725399
71	Diplopia (HP:0000651)	1.80002062
72	Abnormality of binocular vision (HP:0011514)	1.80002062
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78691293
74	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.76597444
75	Male pseudohermaphroditism (HP:0000037)	1.75645158
76	Hemiparesis (HP:0001269)	1.74714126
77	Occipital encephalocele (HP:0002085)	1.73982339
78	Gait imbalance (HP:0002141)	1.73060564
79	Choroideremia (HP:0001139)	1.72163525
80	Macroglossia (HP:0000158)	1.71935743
81	Abnormal urine output (HP:0012590)	1.71921175
82	Abnormality of the renal collecting system (HP:0004742)	1.71347857
83	Abnormality of chloride homeostasis (HP:0011422)	1.69568273
84	Optic nerve coloboma (HP:0000588)	1.67989338
85	Chorioretinal atrophy (HP:0000533)	1.67648409
86	Pendular nystagmus (HP:0012043)	1.67597083
87	Stage 5 chronic kidney disease (HP:0003774)	1.67591638
88	Intellectual disability, severe (HP:0010864)	1.67461522
89	Poor coordination (HP:0002370)	1.67265756
90	Anencephaly (HP:0002323)	1.66261603
91	Hypoalbuminemia (HP:0003073)	1.65740840
92	Abnormal albumin level (HP:0012116)	1.65740840
93	Thyroid-stimulating hormone excess (HP:0002925)	1.64576180
94	Febrile seizures (HP:0002373)	1.64252856
95	Impaired smooth pursuit (HP:0007772)	1.63946372
96	Chronic bronchitis (HP:0004469)	1.61928384
97	Abolished electroretinogram (ERG) (HP:0000550)	1.61739130
98	Abnormality of the nasal septum (HP:0000419)	1.61092362
99	Duplicated collecting system (HP:0000081)	1.60713318
100	Concave nail (HP:0001598)	1.60407799

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.49127453
2	FRK	3.99506520
3	SIK2	3.36198172
4	WNK4	2.78138097
5	TLK1	2.51067629
6	INSRR	2.45462989
7	MAP2K6	2.34452425
8	TNK2	2.16707494
9	NTRK3	1.94574363
10	SIK1	1.79262276
11	BLK	1.71062229
12	AKT3	1.68111366
13	TXK	1.67910022
14	DAPK2	1.63421197
15	ADRBK2	1.60992991
16	MARK2	1.60400006
17	TAOK3	1.59224783
18	GRK1	1.55155223
19	WNK3	1.47583348
20	CAMK1D	1.44185598
21	PRKD2	1.39577186
22	MAP3K7	1.38764067
23	CASK	1.34538871
24	BMPR1B	1.34489004
25	HIPK2	1.33686809
26	MUSK	1.27363870
27	CDK12	1.20116190
28	ACVR1B	1.18519556
29	CHUK	1.18361533
30	TNIK	1.14319087
31	WNK1	1.14286422
32	CAMK1G	1.11988851
33	MAP4K1	1.10596086
34	STK11	1.09191632
35	SGK2	1.06081955
36	EPHA3	1.05311767
37	RPS6KA2	1.02268079
38	BRD4	1.02218481
39	NTRK2	1.00812399
40	MAP4K2	0.97495496
41	RPS6KA6	0.97255388
42	MARK1	0.94335573
43	NLK	0.94290081
44	NME1	0.89918539
45	SGK494	0.84938746
46	SGK223	0.84938746
47	PINK1	0.84228966
48	IKBKB	0.84054746
49	KIT	0.83902239
50	MAPK13	0.83590984
51	SIK3	0.83459380
52	ERBB2	0.82715302
53	ADRBK1	0.82637280
54	CAMKK1	0.81450782
55	PRKCH	0.80900824
56	GRK6	0.78132722
57	CDC42BPA	0.77748139
58	MAP2K2	0.74455842
59	PAK3	0.73834543
60	RPS6KC1	0.73812316
61	RPS6KL1	0.73812316
62	IKBKE	0.73238525
63	PTK2B	0.71578963
64	IRAK1	0.70891526
65	CAMK1	0.70721528
66	FGFR2	0.69619685
67	STK38	0.69002140
68	PRKAA1	0.68425556
69	PRKAA2	0.68356977
70	MARK3	0.67684951
71	PRKD3	0.66500045
72	BTK	0.66004109
73	CAMK4	0.65505354
74	ITK	0.63534991
75	EPHB1	0.63011074
76	DYRK1B	0.62679458
77	MAPK8	0.58930079
78	TRIB3	0.57830374
79	TRPM7	0.55957002
80	MAPK7	0.54398670
81	MAP3K4	0.50836632
82	FES	0.50074846
83	SGK3	0.49871453
84	PRKCZ	0.49865269
85	TEC	0.49851963
86	UHMK1	0.47340268
87	ZAP70	0.47027319
88	MAPK1	0.46138733
89	SGK1	0.45670901
90	SYK	0.44474011
91	RIPK4	0.44315382
92	DYRK2	0.43530773
93	MTOR	0.42952465
94	TAOK2	0.41229365
95	MAPK3	0.40882952
96	PRKD1	0.40876361
97	DYRK1A	0.40524920
98	NEK2	0.40434446
99	PRKCG	0.40274021
100	PDPK1	0.38270446

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.63343431
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.60323648
3	Phototransduction_Homo sapiens_hsa04744	2.17901892
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.98499674
5	Circadian rhythm_Homo sapiens_hsa04710	1.83378969
6	Nicotine addiction_Homo sapiens_hsa05033	1.81033221
7	Notch signaling pathway_Homo sapiens_hsa04330	1.72215327
8	Insulin secretion_Homo sapiens_hsa04911	1.70800747
9	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.69329289
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67618791
11	Ether lipid metabolism_Homo sapiens_hsa00565	1.65426142
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.64346347
13	Taste transduction_Homo sapiens_hsa04742	1.54801709
14	Morphine addiction_Homo sapiens_hsa05032	1.53077715
15	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.51096800
16	ABC transporters_Homo sapiens_hsa02010	1.44446509
17	Cocaine addiction_Homo sapiens_hsa05030	1.43922644
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43524269
19	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.40598243
20	Regulation of autophagy_Homo sapiens_hsa04140	1.40094322
21	Circadian entrainment_Homo sapiens_hsa04713	1.35017000
22	Serotonergic synapse_Homo sapiens_hsa04726	1.34893395
23	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.33986564
24	Glutamatergic synapse_Homo sapiens_hsa04724	1.31502085
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.25426828
26	Lysine degradation_Homo sapiens_hsa00310	1.23218409
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22378447
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.22310745
29	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22197954
30	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.19903541
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19081238
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16502043
33	Cholinergic synapse_Homo sapiens_hsa04725	1.15912602
34	Caffeine metabolism_Homo sapiens_hsa00232	1.14027589
35	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.12009122
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05588099
37	MAPK signaling pathway_Homo sapiens_hsa04010	1.04616833
38	cAMP signaling pathway_Homo sapiens_hsa04024	1.01736460
39	Calcium signaling pathway_Homo sapiens_hsa04020	1.01309156
40	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.99992976
41	Pancreatic secretion_Homo sapiens_hsa04972	0.99909973
42	GABAergic synapse_Homo sapiens_hsa04727	0.98424325
43	Salivary secretion_Homo sapiens_hsa04970	0.96170752
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94571016
45	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.94296823
46	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.93618418
47	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.91985609
48	Primary immunodeficiency_Homo sapiens_hsa05340	0.91105352
49	Renin secretion_Homo sapiens_hsa04924	0.90749463
50	Type II diabetes mellitus_Homo sapiens_hsa04930	0.89339132
51	Amphetamine addiction_Homo sapiens_hsa05031	0.88631819
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.86802029
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.86135657
54	Olfactory transduction_Homo sapiens_hsa04740	0.84314580
55	Long-term depression_Homo sapiens_hsa04730	0.84038365
56	GnRH signaling pathway_Homo sapiens_hsa04912	0.81161686
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.81004034
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.80917082
59	Type I diabetes mellitus_Homo sapiens_hsa04940	0.77484002
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.76419974
61	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.74327675
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72231294
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.69560945
64	Axon guidance_Homo sapiens_hsa04360	0.68648904
65	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.67832723
66	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.67367701
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.67094329
68	Insulin resistance_Homo sapiens_hsa04931	0.65972871
69	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65196407
70	Gastric acid secretion_Homo sapiens_hsa04971	0.63942146
71	Estrogen signaling pathway_Homo sapiens_hsa04915	0.63348711
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61565479
73	Tryptophan metabolism_Homo sapiens_hsa00380	0.61273665
74	FoxO signaling pathway_Homo sapiens_hsa04068	0.60341742
75	Butanoate metabolism_Homo sapiens_hsa00650	0.60212068
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59665750
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58373085
78	VEGF signaling pathway_Homo sapiens_hsa04370	0.57583441
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.56952768
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.56810015
81	Allograft rejection_Homo sapiens_hsa05330	0.56725614
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56474282
83	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55808783
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.55526013
85	Ras signaling pathway_Homo sapiens_hsa04014	0.54972688
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54676431
87	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.54399839
88	Graft-versus-host disease_Homo sapiens_hsa05332	0.53458762
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53005698
90	Asthma_Homo sapiens_hsa05310	0.52112904
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.51790535
92	TNF signaling pathway_Homo sapiens_hsa04668	0.50847578
93	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.50737217
94	Osteoclast differentiation_Homo sapiens_hsa04380	0.50709266
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50616212
96	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.50003108
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.49077190
98	Melanogenesis_Homo sapiens_hsa04916	0.48367402
99	Sulfur relay system_Homo sapiens_hsa04122	0.45373656
100	Bile secretion_Homo sapiens_hsa04976	0.45373606

KIAA1683

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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