ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.53518020
2	presynaptic membrane assembly (GO:0097105)	4.04348744
3	nucleobase catabolic process (GO:0046113)	3.85075626
4	presynaptic membrane organization (GO:0097090)	3.73636950
5	axonal fasciculation (GO:0007413)	3.38318276
6	neural tube formation (GO:0001841)	3.19955659
7	establishment of protein localization to Golgi (GO:0072600)	3.06351026
8	protein targeting to Golgi (GO:0000042)	3.05517150
9	retinal ganglion cell axon guidance (GO:0031290)	3.01951618
10	nonmotile primary cilium assembly (GO:0035058)	3.01522144
11	dendritic spine morphogenesis (GO:0060997)	2.99938358
12	inositol phosphate catabolic process (GO:0071545)	2.99287765
13	regulation of glucokinase activity (GO:0033131)	2.85950056
14	regulation of hexokinase activity (GO:1903299)	2.85950056
15	limb bud formation (GO:0060174)	2.85196283
16	postsynaptic membrane organization (GO:0001941)	2.83388106
17	positive regulation of mitochondrial fission (GO:0090141)	2.79388338
18	neuron recognition (GO:0008038)	2.77883797
19	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.76362916
20	ketone body metabolic process (GO:1902224)	2.75694739
21	positive regulation of glycolytic process (GO:0045821)	2.74444016
22	intraciliary transport (GO:0042073)	2.72998018
23	negative regulation of dendrite development (GO:2000171)	2.72245609
24	cellular ketone body metabolic process (GO:0046950)	2.70397544
25	olfactory bulb development (GO:0021772)	2.67204840
26	protein localization to cilium (GO:0061512)	2.63740501
27	cilium morphogenesis (GO:0060271)	2.62896892
28	righting reflex (GO:0060013)	2.62761133
29	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.61863178
30	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.61863178
31	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.59679739
32	neuron fate determination (GO:0048664)	2.59355225
33	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.58980789
34	cerebral cortex radially oriented cell migration (GO:0021799)	2.58045732
35	central nervous system neuron axonogenesis (GO:0021955)	2.55078881
36	keratinocyte development (GO:0003334)	2.54851045
37	polyol catabolic process (GO:0046174)	2.54423043
38	sympathetic nervous system development (GO:0048485)	2.54412775
39	intra-Golgi vesicle-mediated transport (GO:0006891)	2.54281680
40	synapse assembly (GO:0007416)	2.54096898
41	protein localization to Golgi apparatus (GO:0034067)	2.52874770
42	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52634834
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.52106538
44	cerebral cortex cell migration (GO:0021795)	2.50961481
45	retinal cone cell development (GO:0046549)	2.49567564
46	behavioral response to nicotine (GO:0035095)	2.48264515
47	protein localization to synapse (GO:0035418)	2.47453608
48	response to pheromone (GO:0019236)	2.47092320
49	startle response (GO:0001964)	2.46778830
50	Golgi to endosome transport (GO:0006895)	2.46414916
51	negative regulation of axon guidance (GO:1902668)	2.45735299
52	cilium assembly (GO:0042384)	2.45733459
53	establishment of nucleus localization (GO:0040023)	2.45367154
54	acrosome reaction (GO:0007340)	2.44098057
55	central nervous system projection neuron axonogenesis (GO:0021952)	2.44075674
56	regulation of feeding behavior (GO:0060259)	2.43793906
57	inositol phosphate dephosphorylation (GO:0046855)	2.43715629
58	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.43715629
59	cilium organization (GO:0044782)	2.43296355
60	gamma-aminobutyric acid transport (GO:0015812)	2.43007206
61	regulation of protein glycosylation (GO:0060049)	2.41401509
62	regulation of DNA endoreduplication (GO:0032875)	2.40855227
63	neuronal action potential propagation (GO:0019227)	2.40414941
64	glial cell proliferation (GO:0014009)	2.37766260
65	protein K11-linked deubiquitination (GO:0035871)	2.37478833
66	positive regulation of protein autophosphorylation (GO:0031954)	2.35569420
67	neuron cell-cell adhesion (GO:0007158)	2.33177305
68	auditory behavior (GO:0031223)	2.31980738
69	protein polyglutamylation (GO:0018095)	2.27751435
70	neurotransmitter-gated ion channel clustering (GO:0072578)	2.27141478
71	resolution of meiotic recombination intermediates (GO:0000712)	2.26413655
72	signal peptide processing (GO:0006465)	2.25821307
73	glycosphingolipid biosynthetic process (GO:0006688)	2.25735057
74	dendrite morphogenesis (GO:0048813)	2.25455737
75	magnesium ion transport (GO:0015693)	2.25454084
76	ribonucleoprotein complex disassembly (GO:0032988)	2.25200892
77	establishment of melanosome localization (GO:0032401)	2.24806552
78	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.23807589
79	cornea development in camera-type eye (GO:0061303)	2.23760163
80	regulation of dendritic spine morphogenesis (GO:0061001)	2.22624077
81	melanosome transport (GO:0032402)	2.22434315
82	negative regulation of neurotransmitter transport (GO:0051589)	2.19750487
83	anterograde synaptic vesicle transport (GO:0048490)	2.19444939
84	brain morphogenesis (GO:0048854)	2.18170915
85	lipid particle organization (GO:0034389)	2.17822639
86	calcium ion-dependent exocytosis (GO:0017156)	2.17537879
87	peptidyl-cysteine modification (GO:0018198)	2.17322063
88	regulation of growth hormone secretion (GO:0060123)	2.16881645
89	vascular smooth muscle contraction (GO:0014829)	2.16273004
90	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.15958791
91	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.14128941
92	behavioral response to ethanol (GO:0048149)	2.14001790
93	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.12720547
94	genitalia morphogenesis (GO:0035112)	2.12505448
95	regulation of axon guidance (GO:1902667)	2.12386863
96	appendage development (GO:0048736)	2.11644497
97	limb development (GO:0060173)	2.11644497
98	mechanosensory behavior (GO:0007638)	2.11614751
99	hippocampus development (GO:0021766)	2.11088914
100	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.11035209

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.37422238
2	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.26978008
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.00022322
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.97880418
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.89311555
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.72909392
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69902052
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56105169
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42781202
10	* FUS_26573619_Chip-Seq_HEK293_Human	2.41124527
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34718306
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.23196118
13	P300_19829295_ChIP-Seq_ESCs_Human	2.13932948
14	VDR_22108803_ChIP-Seq_LS180_Human	2.10088073
15	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.08423184
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.05790019
17	EWS_26573619_Chip-Seq_HEK293_Human	1.97558383
18	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.97135752
19	SMAD4_21799915_ChIP-Seq_A2780_Human	1.96361557
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.94011303
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89849591
22	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.88906452
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.88779394
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.88469960
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.87743713
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.85517657
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84139000
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.80616994
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79479212
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79063050
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.78389982
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.76380387
33	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.73993038
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.69426446
35	STAT3_23295773_ChIP-Seq_U87_Human	1.66577560
36	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.61957412
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61846285
38	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.61821928
39	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.61384351
40	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57863681
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57583190
42	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.57033228
43	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.54891945
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54857750
45	* AR_25329375_ChIP-Seq_VCAP_Human	1.54552512
46	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54244810
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.52293306
48	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.49902060
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.49248711
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49248711
51	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.46173662
52	TCF4_23295773_ChIP-Seq_U87_Human	1.45466480
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.39003647
54	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.38825054
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36272988
56	P53_22387025_ChIP-Seq_ESCs_Mouse	1.34233695
57	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34041565
58	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.33432900
59	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.31283272
60	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.29401497
61	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27928969
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.27337620
63	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26549935
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25869723
65	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.25027666
66	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.24324612
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22748961
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21263917
69	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.20760122
70	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.20760122
71	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.20701978
72	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.20366582
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19616986
74	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.17832880
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.16769392
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.16273951
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.15322633
78	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.12989950
79	JUN_21703547_ChIP-Seq_K562_Human	1.12619669
80	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.12599441
81	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11425673
82	P300_18555785_Chip-Seq_ESCs_Mouse	1.10984916
83	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.10520758
84	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10240588
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08715638
86	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08173629
87	AR_21572438_ChIP-Seq_LNCaP_Human	1.08119557
88	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.07396688
89	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06987259
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06970486
91	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06375951
92	CDX2_22108803_ChIP-Seq_LS180_Human	1.05393103
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04878711
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03433164
95	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.03335957
96	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02540242
97	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.01939254
98	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01666402
99	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01666402
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01662168

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.84851778
2	MP0001984_abnormal_olfaction	2.66632693
3	MP0002102_abnormal_ear_morphology	2.57055509
4	MP0003122_maternal_imprinting	2.49699506
5	MP0003880_abnormal_central_pattern	2.32402031
6	MP0004270_analgesia	2.31150149
7	MP0001529_abnormal_vocalization	2.09215281
8	MP0002822_catalepsy	2.00084312
9	MP0009046_muscle_twitch	1.99591283
10	MP0003787_abnormal_imprinting	1.90612891
11	MP0002638_abnormal_pupillary_reflex	1.86011335
12	MP0000778_abnormal_nervous_system	1.82464152
13	MP0003121_genomic_imprinting	1.80379803
14	MP0000372_irregular_coat_pigmentation	1.80295193
15	MP0006276_abnormal_autonomic_nervous	1.76447910
16	MP0002909_abnormal_adrenal_gland	1.76243933
17	MP0006072_abnormal_retinal_apoptosis	1.68404953
18	MP0002938_white_spotting	1.68392094
19	MP0005171_absent_coat_pigmentation	1.67731639
20	MP0005253_abnormal_eye_physiology	1.66282143
21	MP0008877_abnormal_DNA_methylation	1.65151215
22	MP0005187_abnormal_penis_morphology	1.63904493
23	MP0004859_abnormal_synaptic_plasticity	1.63257310
24	MP0002837_dystrophic_cardiac_calcinosis	1.59787312
25	MP0005551_abnormal_eye_electrophysiolog	1.56014780
26	MP0000647_abnormal_sebaceous_gland	1.49493253
27	MP0000427_abnormal_hair_cycle	1.46660496
28	MP0004924_abnormal_behavior	1.39902496
29	MP0005386_behavior/neurological_phenoty	1.39902496
30	MP0009745_abnormal_behavioral_response	1.34181525
31	MP0003635_abnormal_synaptic_transmissio	1.34073198
32	MP0002234_abnormal_pharynx_morphology	1.33572137
33	MP0001486_abnormal_startle_reflex	1.32301991
34	MP0002557_abnormal_social/conspecific_i	1.28286657
35	MP0005645_abnormal_hypothalamus_physiol	1.27903024
36	MP0002272_abnormal_nervous_system	1.27249004
37	MP0005248_abnormal_Harderian_gland	1.26988179
38	MP0002928_abnormal_bile_duct	1.25656907
39	MP0004142_abnormal_muscle_tone	1.25485557
40	MP0002063_abnormal_learning/memory/cond	1.24221264
41	MP0005423_abnormal_somatic_nervous	1.23716851
42	MP0009780_abnormal_chondrocyte_physiolo	1.22967099
43	MP0002751_abnormal_autonomic_nervous	1.22892287
44	MP0006054_spinal_hemorrhage	1.21515874
45	MP0002734_abnormal_mechanical_nocicepti	1.21133272
46	MP0002184_abnormal_innervation	1.20583266
47	MP0002095_abnormal_skin_pigmentation	1.20439736
48	MP0003890_abnormal_embryonic-extraembry	1.17756852
49	MP0002572_abnormal_emotion/affect_behav	1.15994681
50	MP0004885_abnormal_endolymph	1.14806341
51	MP0001299_abnormal_eye_distance/	1.13991711
52	MP0005394_taste/olfaction_phenotype	1.12949992
53	MP0005499_abnormal_olfactory_system	1.12949992
54	MP0004145_abnormal_muscle_electrophysio	1.10917835
55	MP0010234_abnormal_vibrissa_follicle	1.10411191
56	MP0003937_abnormal_limbs/digits/tail_de	1.10337267
57	MP0005174_abnormal_tail_pigmentation	1.09698796
58	MP0002090_abnormal_vision	1.08487874
59	MP0004811_abnormal_neuron_physiology	1.08213991
60	MP0008789_abnormal_olfactory_epithelium	1.07482346
61	MP0004134_abnormal_chest_morphology	1.06454348
62	MP0000631_abnormal_neuroendocrine_gland	1.05256514
63	MP0002064_seizures	1.05136708
64	MP0002177_abnormal_outer_ear	1.04875174
65	MP0010386_abnormal_urinary_bladder	1.03658194
66	MP0002067_abnormal_sensory_capabilities	1.03357817
67	MP0001188_hyperpigmentation	1.02877770
68	MP0003137_abnormal_impulse_conducting	1.01570282
69	MP0003195_calcinosis	1.01397822
70	MP0004215_abnormal_myocardial_fiber	0.99699476
71	MP0002882_abnormal_neuron_morphology	0.97291367
72	MP0000013_abnormal_adipose_tissue	0.96108717
73	MP0000015_abnormal_ear_pigmentation	0.94548796
74	MP0000955_abnormal_spinal_cord	0.93610024
75	MP0002233_abnormal_nose_morphology	0.91727729
76	MP0010678_abnormal_skin_adnexa	0.91399686
77	MP0003221_abnormal_cardiomyocyte_apopto	0.88627342
78	MP0001968_abnormal_touch/_nociception	0.87408613
79	MP0001324_abnormal_eye_pigmentation	0.86752676
80	MP0005408_hypopigmentation	0.86229371
81	MP0003011_delayed_dark_adaptation	0.86225291
82	MP0002736_abnormal_nociception_after	0.85865066
83	MP0005646_abnormal_pituitary_gland	0.84865240
84	MP0003755_abnormal_palate_morphology	0.84751934
85	MP0004133_heterotaxia	0.84466888
86	MP0002752_abnormal_somatic_nervous	0.84256838
87	MP0002160_abnormal_reproductive_system	0.83894762
88	MP0003633_abnormal_nervous_system	0.82495325
89	MP0004085_abnormal_heartbeat	0.82247931
90	MP0000516_abnormal_urinary_system	0.80924944
91	MP0005367_renal/urinary_system_phenotyp	0.80924944
92	MP0003646_muscle_fatigue	0.79873135
93	MP0000538_abnormal_urinary_bladder	0.78607726
94	MP0005391_vision/eye_phenotype	0.77850542
95	MP0003567_abnormal_fetal_cardiomyocyte	0.77205262
96	MP0000749_muscle_degeneration	0.76870947
97	MP0000383_abnormal_hair_follicle	0.74555767
98	MP0002229_neurodegeneration	0.74047164
99	MP0005195_abnormal_posterior_eye	0.74046297
100	MP0005379_endocrine/exocrine_gland_phen	0.73034622

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.28611004
2	Gait imbalance (HP:0002141)	3.26057291
3	Drooling (HP:0002307)	3.12864486
4	Congenital primary aphakia (HP:0007707)	3.09470831
5	Hypoglycemic coma (HP:0001325)	3.05660224
6	Nephrogenic diabetes insipidus (HP:0009806)	2.93000316
7	Pancreatic fibrosis (HP:0100732)	2.83613319
8	Chronic hepatic failure (HP:0100626)	2.83238778
9	True hermaphroditism (HP:0010459)	2.80305833
10	Pancreatic cysts (HP:0001737)	2.77819830
11	Excessive salivation (HP:0003781)	2.74572793
12	Genital tract atresia (HP:0001827)	2.69277935
13	Renal cortical cysts (HP:0000803)	2.64219848
14	Hypoglycemic seizures (HP:0002173)	2.61339778
15	Hypothermia (HP:0002045)	2.60915302
16	Febrile seizures (HP:0002373)	2.57536316
17	Vaginal atresia (HP:0000148)	2.57155525
18	Hyperventilation (HP:0002883)	2.51612179
19	Hyperinsulinemic hypoglycemia (HP:0000825)	2.49389690
20	Abnormality of the renal cortex (HP:0011035)	2.47884651
21	Nephronophthisis (HP:0000090)	2.47866442
22	Exercise-induced muscle cramps (HP:0003710)	2.45618780
23	Calf muscle hypertrophy (HP:0008981)	2.44283892
24	Abnormality of midbrain morphology (HP:0002418)	2.41350649
25	Molar tooth sign on MRI (HP:0002419)	2.41350649
26	Intestinal atresia (HP:0011100)	2.40614582
27	Hypsarrhythmia (HP:0002521)	2.33132845
28	EEG with generalized epileptiform discharges (HP:0011198)	2.31247778
29	Poor coordination (HP:0002370)	2.31214176
30	Delayed gross motor development (HP:0002194)	2.30210772
31	Epileptiform EEG discharges (HP:0011182)	2.27786241
32	Hemiparesis (HP:0001269)	2.23317379
33	Methylmalonic acidemia (HP:0002912)	2.22571823
34	Lissencephaly (HP:0001339)	2.22062419
35	Tubulointerstitial nephritis (HP:0001970)	2.22047970
36	Abnormality of the renal medulla (HP:0100957)	2.20150795
37	Pheochromocytoma (HP:0002666)	2.19664684
38	Papillary thyroid carcinoma (HP:0002895)	2.19072141
39	Ketoacidosis (HP:0001993)	2.17065977
40	Muscle hypertrophy of the lower extremities (HP:0008968)	2.12205979
41	Pachygyria (HP:0001302)	2.08659444
42	Thyroid carcinoma (HP:0002890)	2.08132977
43	Absent speech (HP:0001344)	2.06858534
44	Focal seizures (HP:0007359)	2.05409478
45	Volvulus (HP:0002580)	2.03943280
46	Abnormality of glycolysis (HP:0004366)	2.01242208
47	Limb dystonia (HP:0002451)	2.01200066
48	Type II lissencephaly (HP:0007260)	2.01027299
49	Gaze-evoked nystagmus (HP:0000640)	1.99851273
50	Epidermoid cyst (HP:0200040)	1.99348079
51	Blue irides (HP:0000635)	1.98863076
52	Specific learning disability (HP:0001328)	1.98195517
53	Abnormality of the labia minora (HP:0012880)	1.97254853
54	Polyphagia (HP:0002591)	1.95704942
55	Progressive inability to walk (HP:0002505)	1.94221563
56	Action tremor (HP:0002345)	1.91379656
57	Postaxial hand polydactyly (HP:0001162)	1.90872045
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86488235
59	Abnormality of the metopic suture (HP:0005556)	1.85168371
60	Aplasia/Hypoplasia of the lens (HP:0008063)	1.84687382
61	Neuroendocrine neoplasm (HP:0100634)	1.83994809
62	Agitation (HP:0000713)	1.81681991
63	Abnormality of the musculature of the pelvis (HP:0001469)	1.81272423
64	Abnormality of the hip-girdle musculature (HP:0001445)	1.81272423
65	Fair hair (HP:0002286)	1.80266771
66	Large for gestational age (HP:0001520)	1.79180371
67	Abnormality of the astrocytes (HP:0100707)	1.78962054
68	Astrocytoma (HP:0009592)	1.78962054
69	Cortical dysplasia (HP:0002539)	1.78883445
70	Hyperglycemia (HP:0003074)	1.78792219
71	Retinal dysplasia (HP:0007973)	1.78639074
72	Hamartoma of the eye (HP:0010568)	1.78107798
73	Exotropia (HP:0000577)	1.77668751
74	Muscular hypotonia of the trunk (HP:0008936)	1.77277854
75	Broad-based gait (HP:0002136)	1.76853353
76	Tubulointerstitial abnormality (HP:0001969)	1.76692685
77	Abnormality of the calf musculature (HP:0001430)	1.76167210
78	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.74192871
79	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.74192871
80	Increased serum pyruvate (HP:0003542)	1.72084569
81	Aqueductal stenosis (HP:0002410)	1.71594794
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.70681802
83	Occipital encephalocele (HP:0002085)	1.69792670
84	Narrow forehead (HP:0000341)	1.69718702
85	Abnormality of the fovea (HP:0000493)	1.69058890
86	Short foot (HP:0001773)	1.67829884
87	Furrowed tongue (HP:0000221)	1.67389358
88	Proximal tubulopathy (HP:0000114)	1.67258221
89	Abnormality of vitamin B metabolism (HP:0004340)	1.67222451
90	Inability to walk (HP:0002540)	1.66581547
91	Abnormality of the corticospinal tract (HP:0002492)	1.66543329
92	Progressive cerebellar ataxia (HP:0002073)	1.66318054
93	Labial hypoplasia (HP:0000066)	1.66067213
94	Astigmatism (HP:0000483)	1.65939564
95	Postaxial foot polydactyly (HP:0001830)	1.65173789
96	Amblyopia (HP:0000646)	1.64340841
97	Cystic liver disease (HP:0006706)	1.63939064
98	Hypoplasia of the fovea (HP:0007750)	1.63293716
99	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.63293716
100	Abnormality of macular pigmentation (HP:0008002)	1.63103772

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.59651943
2	CASK	3.40210808
3	MARK1	3.10754554
4	TRIM28	2.85346119
5	BCR	2.69754091
6	MAP3K4	2.60568322
7	ERBB3	2.55254541
8	MAP4K2	2.14906862
9	PLK2	2.14740069
10	WNK3	2.03670345
11	MAPK13	1.85468637
12	TNIK	1.84484355
13	MAP2K7	1.82129672
14	PAK3	1.79262942
15	PNCK	1.73908079
16	FGFR2	1.71805898
17	PINK1	1.60391635
18	EIF2AK3	1.56930370
19	CSNK1G2	1.50746110
20	AKT3	1.48119680
21	STK38L	1.41634318
22	CSNK1G1	1.37346531
23	EIF2AK1	1.36595279
24	OBSCN	1.34649995
25	BMPR1B	1.28519596
26	PHKG1	1.26858444
27	PHKG2	1.26858444
28	CSNK1G3	1.21469114
29	MKNK2	1.21196578
30	CSNK1A1L	1.17424324
31	GRK1	1.16221494
32	FER	1.14444838
33	EPHA3	1.12267700
34	PRKCE	1.08843453
35	PKN2	1.05136918
36	EPHA4	1.04574456
37	INSRR	1.01982810
38	CAMKK2	1.01520883
39	STK39	0.98814700
40	SGK2	0.98726239
41	MINK1	0.98328149
42	NTRK3	0.96223628
43	PRKCG	0.95175600
44	ADRBK2	0.93966037
45	MAP2K4	0.93556796
46	NEK1	0.92377772
47	STK24	0.89430426
48	NTRK2	0.89376554
49	WEE1	0.88299296
50	ACVR1B	0.88105078
51	PRKD3	0.86476448
52	RPS6KA4	0.83177854
53	DYRK2	0.82903027
54	MAP3K12	0.82228554
55	PLK3	0.81862257
56	KSR1	0.81078338
57	SGK223	0.78185794
58	SGK494	0.78185794
59	CAMK1G	0.77473876
60	OXSR1	0.73533860
61	PAK6	0.70063852
62	LIMK1	0.68792634
63	FLT3	0.68161524
64	NUAK1	0.65786894
65	BRD4	0.65344511
66	BRSK2	0.65302251
67	SRPK1	0.65121296
68	FGFR1	0.63883157
69	CAMK2A	0.63790576
70	PRKAA1	0.59746440
71	MAP3K2	0.58857455
72	MKNK1	0.58146346
73	WNK4	0.54474384
74	STK3	0.52863231
75	CAMK2D	0.51785105
76	YES1	0.50644589
77	DYRK3	0.50599799
78	CDK3	0.50125140
79	SGK3	0.49846551
80	CSNK1D	0.49511212
81	PLK4	0.48380811
82	UHMK1	0.47834364
83	DYRK1A	0.45321884
84	CAMK2B	0.45039316
85	CDK5	0.43931554
86	SIK3	0.43244596
87	FGFR3	0.39527386
88	MET	0.39511423
89	PRKG1	0.39497099
90	ADRBK1	0.38555842
91	PRKACB	0.37958041
92	PRKACA	0.35983834
93	ERBB2	0.35974854
94	MAP3K6	0.35508224
95	ATM	0.34919836
96	PRKAA2	0.34598872
97	PIK3CA	0.33248701
98	CCNB1	0.33197989
99	CSNK1E	0.33056495
100	PTK2B	0.32549168

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.28368769
2	Protein export_Homo sapiens_hsa03060	3.18378997
3	Butanoate metabolism_Homo sapiens_hsa00650	2.60918783
4	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.58275547
5	Nicotine addiction_Homo sapiens_hsa05033	2.23840801
6	Propanoate metabolism_Homo sapiens_hsa00640	2.23503412
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.13936160
8	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.84501505
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78891423
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.72602030
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.65910762
12	Circadian rhythm_Homo sapiens_hsa04710	1.63153095
13	Fatty acid elongation_Homo sapiens_hsa00062	1.58929144
14	Phototransduction_Homo sapiens_hsa04744	1.53108326
15	Insulin secretion_Homo sapiens_hsa04911	1.52355159
16	GABAergic synapse_Homo sapiens_hsa04727	1.46014022
17	Dopaminergic synapse_Homo sapiens_hsa04728	1.43763825
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41985085
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.39729907
20	Glutamatergic synapse_Homo sapiens_hsa04724	1.34902243
21	Circadian entrainment_Homo sapiens_hsa04713	1.32183538
22	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.29184744
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28119924
24	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.21201628
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18880175
26	Amphetamine addiction_Homo sapiens_hsa05031	1.16539852
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13517453
28	Morphine addiction_Homo sapiens_hsa05032	1.07381400
29	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.06402621
30	Cocaine addiction_Homo sapiens_hsa05030	1.06115594
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.05854224
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04254172
33	Peroxisome_Homo sapiens_hsa04146	0.98929125
34	Type II diabetes mellitus_Homo sapiens_hsa04930	0.98923887
35	Regulation of autophagy_Homo sapiens_hsa04140	0.98384955
36	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.97889908
37	Taste transduction_Homo sapiens_hsa04742	0.96782316
38	Axon guidance_Homo sapiens_hsa04360	0.93437878
39	Basal transcription factors_Homo sapiens_hsa03022	0.93170248
40	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.92969111
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.90020466
42	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.87947920
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.87901193
44	Serotonergic synapse_Homo sapiens_hsa04726	0.86031008
45	Long-term depression_Homo sapiens_hsa04730	0.85955170
46	Oocyte meiosis_Homo sapiens_hsa04114	0.85287998
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82263835
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80943208
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80102817
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.80090433
51	RNA degradation_Homo sapiens_hsa03018	0.80000229
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77650823
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.76861435
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74142874
55	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73279582
56	Renin secretion_Homo sapiens_hsa04924	0.73248415
57	Fatty acid degradation_Homo sapiens_hsa00071	0.72732550
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71444049
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71205313
60	Olfactory transduction_Homo sapiens_hsa04740	0.69371669
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.69007317
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68872598
63	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.68614508
64	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.68257956
65	Caffeine metabolism_Homo sapiens_hsa00232	0.67163753
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.66665879
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66342742
68	Folate biosynthesis_Homo sapiens_hsa00790	0.65690557
69	ABC transporters_Homo sapiens_hsa02010	0.64145385
70	Cholinergic synapse_Homo sapiens_hsa04725	0.61179739
71	AMPK signaling pathway_Homo sapiens_hsa04152	0.60507807
72	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59389943
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.57969796
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56383519
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.56317914
76	Parkinsons disease_Homo sapiens_hsa05012	0.56163668
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56016551
78	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.53945608
79	Vibrio cholerae infection_Homo sapiens_hsa05110	0.53767914
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.53445020
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.53112191
82	Salivary secretion_Homo sapiens_hsa04970	0.53011286
83	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.52854456
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.51988028
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51086148
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50724993
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.50488063
88	Lysine degradation_Homo sapiens_hsa00310	0.50280975
89	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.49384427
90	Alcoholism_Homo sapiens_hsa05034	0.49126162
91	Gap junction_Homo sapiens_hsa04540	0.48323080
92	Glucagon signaling pathway_Homo sapiens_hsa04922	0.44725895
93	mTOR signaling pathway_Homo sapiens_hsa04150	0.44609488
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.44187923
95	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.43158325
96	Alzheimers disease_Homo sapiens_hsa05010	0.41914987
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.41357947
98	Metabolic pathways_Homo sapiens_hsa01100	0.40746576
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40614711
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.39049207

KIAA1715

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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