ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.07282963
2	epithelial cilium movement (GO:0003351)	5.82955279
3	cilium movement (GO:0003341)	5.60467286
4	cilium or flagellum-dependent cell motility (GO:0001539)	5.41574139
5	axonemal dynein complex assembly (GO:0070286)	5.33527151
6	behavioral response to nicotine (GO:0035095)	4.88192461
7	pyrimidine nucleobase catabolic process (GO:0006208)	4.61648251
8	axoneme assembly (GO:0035082)	4.44797895
9	regulation of cilium movement (GO:0003352)	4.39148102
10	intraciliary transport (GO:0042073)	4.22074638
11	protein polyglutamylation (GO:0018095)	3.94364841
12	protein localization to cilium (GO:0061512)	3.89127301
13	nonmotile primary cilium assembly (GO:0035058)	3.87291320
14	cilium organization (GO:0044782)	3.82932741
15	cilium assembly (GO:0042384)	3.77532943
16	nucleobase catabolic process (GO:0046113)	3.74901912
17	presynaptic membrane assembly (GO:0097105)	3.73677905
18	cilium morphogenesis (GO:0060271)	3.54674460
19	postsynaptic membrane organization (GO:0001941)	3.54265707
20	neural tube formation (GO:0001841)	3.52713272
21	presynaptic membrane organization (GO:0097090)	3.52676153
22	retinal ganglion cell axon guidance (GO:0031290)	3.46152890
23	motile cilium assembly (GO:0044458)	3.18927441
24	response to pheromone (GO:0019236)	3.07310933
25	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.05665261
26	limb bud formation (GO:0060174)	3.04762927
27	cellular component assembly involved in morphogenesis (GO:0010927)	3.02679680
28	microtubule bundle formation (GO:0001578)	3.01552367
29	behavioral response to ethanol (GO:0048149)	3.01429754
30	axonal fasciculation (GO:0007413)	3.00145741
31	regulation of microtubule-based movement (GO:0060632)	2.96973529
32	retinal cone cell development (GO:0046549)	2.96189411
33	photoreceptor cell maintenance (GO:0045494)	2.91242379
34	olfactory bulb development (GO:0021772)	2.90693799
35	neuron cell-cell adhesion (GO:0007158)	2.89369184
36	cornea development in camera-type eye (GO:0061303)	2.86488753
37	transmission of nerve impulse (GO:0019226)	2.85389316
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84469686
39	auditory behavior (GO:0031223)	2.78884963
40	left/right axis specification (GO:0070986)	2.78811884
41	smoothened signaling pathway (GO:0007224)	2.78768841
42	regulation of collateral sprouting (GO:0048670)	2.76107696
43	protein localization to synapse (GO:0035418)	2.71607190
44	neuron recognition (GO:0008038)	2.71491021
45	DNA double-strand break processing (GO:0000729)	2.70339167
46	gamma-aminobutyric acid transport (GO:0015812)	2.67641365
47	appendage development (GO:0048736)	2.67540484
48	limb development (GO:0060173)	2.67540484
49	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66973127
50	left/right pattern formation (GO:0060972)	2.66900546
51	neurotransmitter-gated ion channel clustering (GO:0072578)	2.66386077
52	platelet dense granule organization (GO:0060155)	2.66151255
53	determination of left/right symmetry (GO:0007368)	2.65805836
54	centriole replication (GO:0007099)	2.64822578
55	fucose catabolic process (GO:0019317)	2.63777681
56	L-fucose metabolic process (GO:0042354)	2.63777681
57	L-fucose catabolic process (GO:0042355)	2.63777681
58	synapse assembly (GO:0007416)	2.57751295
59	head development (GO:0060322)	2.56859969
60	somite development (GO:0061053)	2.56219372
61	cerebral cortex radially oriented cell migration (GO:0021799)	2.55155722
62	ventricular system development (GO:0021591)	2.54910982
63	dendritic spine morphogenesis (GO:0060997)	2.53749284
64	vocalization behavior (GO:0071625)	2.53202128
65	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.52546489
66	determination of bilateral symmetry (GO:0009855)	2.51783885
67	kidney morphogenesis (GO:0060993)	2.51685563
68	photoreceptor cell development (GO:0042461)	2.49170554
69	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47906268
70	central nervous system projection neuron axonogenesis (GO:0021952)	2.46991059
71	tachykinin receptor signaling pathway (GO:0007217)	2.46726349
72	mechanosensory behavior (GO:0007638)	2.45996351
73	synaptic transmission, cholinergic (GO:0007271)	2.45213796
74	specification of symmetry (GO:0009799)	2.44586072
75	spinal cord development (GO:0021510)	2.42683681
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.42235792
77	NADH dehydrogenase complex assembly (GO:0010257)	2.42235792
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.42235792
79	microtubule-based movement (GO:0007018)	2.41652205
80	replication fork processing (GO:0031297)	2.40877838
81	cell proliferation in forebrain (GO:0021846)	2.40594770
82	establishment of protein localization to Golgi (GO:0072600)	2.38076867
83	neurofilament cytoskeleton organization (GO:0060052)	2.35881625
84	central nervous system neuron axonogenesis (GO:0021955)	2.35540083
85	regulation of telomere maintenance (GO:0032204)	2.34616311
86	microtubule depolymerization (GO:0007019)	2.34215323
87	cell projection assembly (GO:0030031)	2.33925375
88	negative regulation of axon guidance (GO:1902668)	2.33345562
89	negative regulation of telomere maintenance (GO:0032205)	2.33321689
90	startle response (GO:0001964)	2.32268316
91	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.31323404
92	protein complex biogenesis (GO:0070271)	2.31249861
93	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.30910621
94	regulation of sarcomere organization (GO:0060297)	2.30480112
95	regulation of action potential (GO:0098900)	2.28846269
96	hindbrain development (GO:0030902)	2.28818404
97	short-term memory (GO:0007614)	2.28512626
98	brain morphogenesis (GO:0048854)	2.26047394
99	kynurenine metabolic process (GO:0070189)	2.25464849
100	eye photoreceptor cell development (GO:0042462)	2.25425042

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.34703463
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.24085273
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19277528
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.93203178
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.76111931
6	VDR_22108803_ChIP-Seq_LS180_Human	2.73500625
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64987019
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58393212
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46499529
10	FUS_26573619_Chip-Seq_HEK293_Human	2.39612606
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.37601805
12	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.33753477
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30814007
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.28323589
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26559302
16	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20995131
17	EWS_26573619_Chip-Seq_HEK293_Human	2.17657168
18	P300_19829295_ChIP-Seq_ESCs_Human	2.14620416
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.12060909
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09588522
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85394131
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80803093
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79946256
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79423841
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.78383350
26	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.77162821
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.73898380
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.68409713
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.66952605
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65588165
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.65277433
32	STAT3_23295773_ChIP-Seq_U87_Human	1.61710428
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61037488
34	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.61037488
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.60563222
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.59593172
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57299937
38	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57249995
39	AR_25329375_ChIP-Seq_VCAP_Human	1.54670853
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.54350064
41	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.54180507
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52772243
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50102301
44	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49517747
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49361472
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.49361472
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48289531
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47962539
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45538487
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.45167779
51	TCF4_23295773_ChIP-Seq_U87_Human	1.44569782
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41990399
53	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40890724
54	AR_21572438_ChIP-Seq_LNCaP_Human	1.33511589
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31126639
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30985788
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30761496
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.28356503
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27036341
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.26882997
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25574420
62	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.21835167
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.21397549
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.20339093
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.20253151
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19301837
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19011632
68	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17569479
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17361514
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.17198521
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16862978
72	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.16149351
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15878970
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15758633
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13630257
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12658162
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12650337
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.12116215
79	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12014814
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11745418
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11104304
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11104304
83	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10307844
84	JUN_21703547_ChIP-Seq_K562_Human	1.08886262
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08030622
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07304207
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05876800
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05755857
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05369730
90	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01228937
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00442849
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00013211
93	TP53_16413492_ChIP-PET_HCT116_Human	0.99216498
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.99189480
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98948237
96	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.97094338
97	MYC_18940864_ChIP-ChIP_HL60_Human	0.96885803
98	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96655761
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96590646
100	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95018248

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.86661993
2	MP0003787_abnormal_imprinting	2.65408743
3	MP0002653_abnormal_ependyma_morphology	2.60054182
4	MP0001984_abnormal_olfaction	2.37435922
5	MP0002102_abnormal_ear_morphology	2.30869105
6	MP0000778_abnormal_nervous_system	2.27784933
7	MP0006276_abnormal_autonomic_nervous	2.20573007
8	MP0006292_abnormal_olfactory_placode	2.20512131
9	MP0008877_abnormal_DNA_methylation	2.18168773
10	MP0008789_abnormal_olfactory_epithelium	2.18110658
11	MP0001529_abnormal_vocalization	2.08961375
12	MP0005551_abnormal_eye_electrophysiolog	2.05458635
13	MP0004133_heterotaxia	2.04107265
14	MP0009046_muscle_twitch	1.97369318
15	MP0003122_maternal_imprinting	1.96607595
16	MP0005394_taste/olfaction_phenotype	1.95502603
17	MP0005499_abnormal_olfactory_system	1.95502603
18	MP0003136_yellow_coat_color	1.94463715
19	MP0003890_abnormal_embryonic-extraembry	1.93643430
20	MP0000569_abnormal_digit_pigmentation	1.87330119
21	MP0003121_genomic_imprinting	1.82127367
22	MP0001968_abnormal_touch/_nociception	1.81582711
23	MP0006072_abnormal_retinal_apoptosis	1.72309110
24	MP0009745_abnormal_behavioral_response	1.69139005
25	MP0001486_abnormal_startle_reflex	1.66655928
26	MP0002272_abnormal_nervous_system	1.63440378
27	MP0002638_abnormal_pupillary_reflex	1.63282170
28	MP0005253_abnormal_eye_physiology	1.62214064
29	MP0002736_abnormal_nociception_after	1.60887995
30	MP0001485_abnormal_pinna_reflex	1.59458635
31	MP0002735_abnormal_chemical_nociception	1.59045844
32	MP0000631_abnormal_neuroendocrine_gland	1.57676561
33	MP0002734_abnormal_mechanical_nocicepti	1.56813560
34	MP0004142_abnormal_muscle_tone	1.56675651
35	MP0002938_white_spotting	1.56181464
36	MP0004270_analgesia	1.53838521
37	MP0005646_abnormal_pituitary_gland	1.53376481
38	MP0005645_abnormal_hypothalamus_physiol	1.53210634
39	MP0003635_abnormal_synaptic_transmissio	1.49016470
40	MP0002822_catalepsy	1.47792161
41	MP0004885_abnormal_endolymph	1.47575757
42	MP0008875_abnormal_xenobiotic_pharmacok	1.44512488
43	MP0002572_abnormal_emotion/affect_behav	1.44439390
44	MP0002837_dystrophic_cardiac_calcinosis	1.43827169
45	MP0002557_abnormal_social/conspecific_i	1.40879805
46	MP0005423_abnormal_somatic_nervous	1.39963008
47	MP0004742_abnormal_vestibular_system	1.39204025
48	MP0003195_calcinosis	1.38249129
49	MP0002184_abnormal_innervation	1.35246720
50	MP0004043_abnormal_pH_regulation	1.34912730
51	MP0001293_anophthalmia	1.34779191
52	MP0000427_abnormal_hair_cycle	1.34331079
53	MP0000955_abnormal_spinal_cord	1.34118928
54	MP0003937_abnormal_limbs/digits/tail_de	1.30825006
55	MP0002063_abnormal_learning/memory/cond	1.30744314
56	MP0002067_abnormal_sensory_capabilities	1.27456662
57	MP0004924_abnormal_behavior	1.26334999
58	MP0005386_behavior/neurological_phenoty	1.26334999
59	MP0002752_abnormal_somatic_nervous	1.25494852
60	MP0002234_abnormal_pharynx_morphology	1.24837778
61	MP0001970_abnormal_pain_threshold	1.23936957
62	MP0002233_abnormal_nose_morphology	1.21462905
63	MP0004859_abnormal_synaptic_plasticity	1.20908328
64	MP0005195_abnormal_posterior_eye	1.19944950
65	MP0002064_seizures	1.19673566
66	MP0002160_abnormal_reproductive_system	1.18617570
67	MP0002751_abnormal_autonomic_nervous	1.16381135
68	MP0002882_abnormal_neuron_morphology	1.14950676
69	MP0003646_muscle_fatigue	1.12879730
70	MP0001986_abnormal_taste_sensitivity	1.07806845
71	MP0000049_abnormal_middle_ear	1.07674540
72	MP0008872_abnormal_physiological_respon	1.06655083
73	MP0000372_irregular_coat_pigmentation	1.02940306
74	MP0004145_abnormal_muscle_electrophysio	1.01227172
75	MP0000383_abnormal_hair_follicle	1.01167609
76	MP0002733_abnormal_thermal_nociception	1.00791230
77	MP0000647_abnormal_sebaceous_gland	0.99261716
78	MP0001188_hyperpigmentation	0.99205650
79	MP0003119_abnormal_digestive_system	0.98249688
80	MP0003283_abnormal_digestive_organ	0.97954284
81	MP0000026_abnormal_inner_ear	0.97260217
82	MP0003861_abnormal_nervous_system	0.95849829
83	MP0005187_abnormal_penis_morphology	0.95829420
84	MP0002163_abnormal_gland_morphology	0.94805564
85	MP0001324_abnormal_eye_pigmentation	0.94071555
86	MP0005391_vision/eye_phenotype	0.93976909
87	MP0002876_abnormal_thyroid_physiology	0.93384838
88	MP0002152_abnormal_brain_morphology	0.93214676
89	MP0004811_abnormal_neuron_physiology	0.91166631
90	MP0000566_synostosis	0.88155164
91	MP0002928_abnormal_bile_duct	0.86664302
92	MP0005389_reproductive_system_phenotype	0.86572034
93	MP0003011_delayed_dark_adaptation	0.86274679
94	MP0005084_abnormal_gallbladder_morpholo	0.85211672
95	MP0004147_increased_porphyrin_level	0.84582516
96	MP0001963_abnormal_hearing_physiology	0.84180096
97	MP0002229_neurodegeneration	0.83995631
98	MP0010386_abnormal_urinary_bladder	0.83873564
99	MP0002909_abnormal_adrenal_gland	0.83467945
100	MP0003755_abnormal_palate_morphology	0.80823508

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.66527830
2	Abnormal respiratory motile cilium morphology (HP:0005938)	4.66423784
3	Abnormal respiratory epithelium morphology (HP:0012253)	4.66423784
4	Pancreatic fibrosis (HP:0100732)	4.49467378
5	Pancreatic cysts (HP:0001737)	4.40696095
6	Abnormal ciliary motility (HP:0012262)	4.32450257
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.29697718
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.28903516
9	Absent/shortened dynein arms (HP:0200106)	4.28903516
10	Abnormality of midbrain morphology (HP:0002418)	4.26274297
11	Molar tooth sign on MRI (HP:0002419)	4.26274297
12	True hermaphroditism (HP:0010459)	4.25944886
13	Nephronophthisis (HP:0000090)	3.95184270
14	Rhinitis (HP:0012384)	3.76849614
15	Medial flaring of the eyebrow (HP:0010747)	3.75569589
16	Gait imbalance (HP:0002141)	3.48184803
17	Abnormality of the renal medulla (HP:0100957)	3.40912451
18	Chronic hepatic failure (HP:0100626)	3.35974521
19	Congenital primary aphakia (HP:0007707)	3.31279256
20	Nephrogenic diabetes insipidus (HP:0009806)	3.04031908
21	Hyperventilation (HP:0002883)	2.98560903
22	Cystic liver disease (HP:0006706)	2.97379448
23	Genital tract atresia (HP:0001827)	2.92827041
24	Vaginal atresia (HP:0000148)	2.89097284
25	Abnormality of the renal cortex (HP:0011035)	2.79777131
26	Postaxial foot polydactyly (HP:0001830)	2.77130966
27	Occipital encephalocele (HP:0002085)	2.70063989
28	Tubulointerstitial nephritis (HP:0001970)	2.58149860
29	Anencephaly (HP:0002323)	2.57822560
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.57079726
31	Chronic bronchitis (HP:0004469)	2.55254792
32	Sclerocornea (HP:0000647)	2.53372702
33	Postaxial hand polydactyly (HP:0001162)	2.48834558
34	Tubular atrophy (HP:0000092)	2.46811264
35	Poor coordination (HP:0002370)	2.42924910
36	Congenital hepatic fibrosis (HP:0002612)	2.39292291
37	Broad-based gait (HP:0002136)	2.38576124
38	Lissencephaly (HP:0001339)	2.34662058
39	Type II lissencephaly (HP:0007260)	2.33483177
40	Oligodactyly (hands) (HP:0001180)	2.31976242
41	Bronchiectasis (HP:0002110)	2.30024235
42	Absent speech (HP:0001344)	2.23643187
43	Congenital stationary night blindness (HP:0007642)	2.21915835
44	Anophthalmia (HP:0000528)	2.17080777
45	Preaxial hand polydactyly (HP:0001177)	2.17007655
46	Drooling (HP:0002307)	2.16497056
47	Progressive cerebellar ataxia (HP:0002073)	2.14745993
48	Supernumerary spleens (HP:0009799)	2.13565906
49	Intestinal atresia (HP:0011100)	2.13508110
50	Abnormality of the labia minora (HP:0012880)	2.10344140
51	Specific learning disability (HP:0001328)	2.06017596
52	Narrow forehead (HP:0000341)	2.04872922
53	Abnormal drinking behavior (HP:0030082)	2.03938456
54	Polydipsia (HP:0001959)	2.03938456
55	Male pseudohermaphroditism (HP:0000037)	2.03383325
56	Tubulointerstitial abnormality (HP:0001969)	2.01954474
57	Focal seizures (HP:0007359)	2.01651401
58	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99068032
59	Febrile seizures (HP:0002373)	1.98961311
60	Abolished electroretinogram (ERG) (HP:0000550)	1.97418000
61	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.95679149
62	Focal motor seizures (HP:0011153)	1.93602056
63	Renal cortical cysts (HP:0000803)	1.91446080
64	Pendular nystagmus (HP:0012043)	1.90622092
65	Hyperglycinemia (HP:0002154)	1.89311298
66	Excessive salivation (HP:0003781)	1.89277550
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87599754
68	Furrowed tongue (HP:0000221)	1.87387430
69	Pachygyria (HP:0001302)	1.87188358
70	Colon cancer (HP:0003003)	1.86834640
71	Dandy-Walker malformation (HP:0001305)	1.85484851
72	Cerebellar dysplasia (HP:0007033)	1.81964707
73	Asplenia (HP:0001746)	1.81952436
74	Aganglionic megacolon (HP:0002251)	1.81458590
75	Optic nerve hypoplasia (HP:0000609)	1.81157136
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.79855138
77	Protruding tongue (HP:0010808)	1.79402460
78	Polyphagia (HP:0002591)	1.79196885
79	Broad foot (HP:0001769)	1.78416813
80	Gaze-evoked nystagmus (HP:0000640)	1.78026262
81	Attenuation of retinal blood vessels (HP:0007843)	1.77878488
82	Inability to walk (HP:0002540)	1.77757546
83	Decreased central vision (HP:0007663)	1.77597128
84	Retinal dysplasia (HP:0007973)	1.77115039
85	Multicystic kidney dysplasia (HP:0000003)	1.77053743
86	Limb dystonia (HP:0002451)	1.76330798
87	Genetic anticipation (HP:0003743)	1.76012757
88	Retinitis pigmentosa (HP:0000510)	1.74999909
89	Oculomotor apraxia (HP:0000657)	1.73218173
90	Prominent nasal bridge (HP:0000426)	1.72530410
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.72147291
92	Astigmatism (HP:0000483)	1.68912163
93	Abnormal biliary tract physiology (HP:0012439)	1.68111521
94	Bile duct proliferation (HP:0001408)	1.68111521
95	Short foot (HP:0001773)	1.67307690
96	Dialeptic seizures (HP:0011146)	1.66523642
97	Bifid tongue (HP:0010297)	1.65932159
98	Patellar aplasia (HP:0006443)	1.65232935
99	Volvulus (HP:0002580)	1.65169335
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.64477291

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.28607611
2	CASK	4.01983363
3	WNK3	3.29112639
4	BMPR1B	3.00248581
5	MAP4K2	2.75307706
6	MARK1	2.45165466
7	BCR	2.30801311
8	MAP3K4	2.27629292
9	TNIK	2.13842467
10	MAPK13	2.10445712
11	ZAK	1.96335946
12	ADRBK2	1.92142881
13	PINK1	1.89448889
14	ACVR1B	1.89245132
15	MAP2K7	1.86434088
16	TRIM28	1.83129453
17	NUAK1	1.74048840
18	DYRK2	1.70190218
19	WNK4	1.66487470
20	ERBB3	1.53509736
21	PAK3	1.49001049
22	MAPK15	1.46754521
23	GRK1	1.42816940
24	TLK1	1.42773764
25	CSNK1G2	1.40075394
26	EPHA4	1.38781514
27	STK39	1.30435441
28	INSRR	1.29793701
29	NTRK2	1.29061916
30	MKNK2	1.28417509
31	PLK2	1.26540910
32	STK38L	1.23802727
33	PNCK	1.21447095
34	SIK2	1.21329578
35	CSNK1G1	1.12024494
36	CSNK1G3	1.10713907
37	CSNK1A1L	1.08687522
38	EPHA3	1.08516466
39	NTRK3	1.08194528
40	OXSR1	1.06780007
41	MINK1	1.01592840
42	PRKCG	1.00046362
43	CAMKK2	0.96985979
44	TGFBR1	0.94075594
45	BRSK2	0.90941297
46	DYRK3	0.90717143
47	PRKCE	0.89105471
48	WEE1	0.87707490
49	MKNK1	0.85399276
50	ADRBK1	0.82819080
51	DAPK2	0.81649030
52	FGFR2	0.81648977
53	PLK4	0.81565752
54	STK3	0.79985585
55	TIE1	0.79135949
56	MAP2K4	0.75287996
57	NEK2	0.71619575
58	LATS1	0.68099495
59	DYRK1A	0.65619173
60	CAMK2A	0.62398075
61	PTK2B	0.57706142
62	PKN1	0.57701876
63	PLK3	0.55924042
64	PLK1	0.55831986
65	PIK3CA	0.55049283
66	BCKDK	0.54403082
67	CCNB1	0.53306772
68	ERBB2	0.52249652
69	TAOK3	0.51442143
70	EPHB2	0.50493818
71	MUSK	0.48040794
72	CDK5	0.47883916
73	CAMK1	0.46591121
74	VRK1	0.46145876
75	CAMK1G	0.45974509
76	EIF2AK3	0.44276003
77	PHKG1	0.44247313
78	PHKG2	0.44247313
79	STK11	0.43911759
80	PRKACA	0.43327964
81	AKT3	0.41813714
82	SGK223	0.41655560
83	SGK494	0.41655560
84	UHMK1	0.41352965
85	CSNK1D	0.39177200
86	SGK2	0.38973336
87	TAF1	0.38844278
88	CSNK1A1	0.38546982
89	PRKCZ	0.37966465
90	NME1	0.36395193
91	CAMK4	0.33493044
92	CHEK2	0.33092900
93	MST4	0.32779690
94	ATR	0.31976191
95	CSNK1E	0.31945151
96	STK24	0.31608915
97	PRKG1	0.31039809
98	MAPKAPK5	0.30291209
99	FER	0.30052134
100	SRPK1	0.28168554

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.11849240
2	Phototransduction_Homo sapiens_hsa04744	2.78488623
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.74924271
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.32638477
5	Protein export_Homo sapiens_hsa03060	2.28318010
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.28259184
7	Butanoate metabolism_Homo sapiens_hsa00650	2.07598625
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.00728095
9	Oxidative phosphorylation_Homo sapiens_hsa00190	1.90829802
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.89399438
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80953901
12	Propanoate metabolism_Homo sapiens_hsa00640	1.78827293
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.74224545
14	Morphine addiction_Homo sapiens_hsa05032	1.72394062
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68947940
16	GABAergic synapse_Homo sapiens_hsa04727	1.67563054
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.65032464
18	Taste transduction_Homo sapiens_hsa04742	1.64991680
19	Homologous recombination_Homo sapiens_hsa03440	1.61794104
20	Huntingtons disease_Homo sapiens_hsa05016	1.60270211
21	Parkinsons disease_Homo sapiens_hsa05012	1.57553878
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57152151
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56218928
24	Basal transcription factors_Homo sapiens_hsa03022	1.55945734
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.55504042
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.50485817
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.49564220
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.49452939
29	Caffeine metabolism_Homo sapiens_hsa00232	1.43340781
30	Circadian entrainment_Homo sapiens_hsa04713	1.42202788
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.41876690
32	Regulation of autophagy_Homo sapiens_hsa04140	1.31587506
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26214896
34	Dopaminergic synapse_Homo sapiens_hsa04728	1.24180880
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.23611411
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.23176164
37	Axon guidance_Homo sapiens_hsa04360	1.23041535
38	RNA degradation_Homo sapiens_hsa03018	1.22543845
39	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.21505298
40	Olfactory transduction_Homo sapiens_hsa04740	1.20323508
41	Serotonergic synapse_Homo sapiens_hsa04726	1.18703633
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.17981181
43	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17229703
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.14681556
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13979264
46	Peroxisome_Homo sapiens_hsa04146	1.13743218
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09569345
48	Tryptophan metabolism_Homo sapiens_hsa00380	1.09236131
49	Basal cell carcinoma_Homo sapiens_hsa05217	1.08491471
50	Alzheimers disease_Homo sapiens_hsa05010	1.06016858
51	Insulin secretion_Homo sapiens_hsa04911	1.05193388
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98996654
53	ABC transporters_Homo sapiens_hsa02010	0.98505107
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96143113
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92822633
56	Circadian rhythm_Homo sapiens_hsa04710	0.91387959
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91258777
58	RNA polymerase_Homo sapiens_hsa03020	0.91042931
59	Cocaine addiction_Homo sapiens_hsa05030	0.90490345
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90163371
61	Salivary secretion_Homo sapiens_hsa04970	0.83415169
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.82928478
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79579363
64	Long-term depression_Homo sapiens_hsa04730	0.79121286
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.76968050
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76910309
67	Retinol metabolism_Homo sapiens_hsa00830	0.76190876
68	Histidine metabolism_Homo sapiens_hsa00340	0.74697541
69	Cholinergic synapse_Homo sapiens_hsa04725	0.72560426
70	Amphetamine addiction_Homo sapiens_hsa05031	0.72169307
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70538097
72	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.68116548
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.67350960
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64255589
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.59311392
76	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.58805185
77	Metabolic pathways_Homo sapiens_hsa01100	0.54742519
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54718004
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54508290
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.53365258
81	Purine metabolism_Homo sapiens_hsa00230	0.52409321
82	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51418195
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49313842
84	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.47791426
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47408831
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.47342886
87	Fatty acid degradation_Homo sapiens_hsa00071	0.45560118
88	Wnt signaling pathway_Homo sapiens_hsa04310	0.45425390
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.44518160
90	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43132012
91	Alcoholism_Homo sapiens_hsa05034	0.42187087
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.41562987
93	Nucleotide excision repair_Homo sapiens_hsa03420	0.40916294
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39428130
95	Gastric acid secretion_Homo sapiens_hsa04971	0.38612575
96	Oocyte meiosis_Homo sapiens_hsa04114	0.37780844
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37735062
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.33657314
99	Melanogenesis_Homo sapiens_hsa04916	0.30711006
100	One carbon pool by folate_Homo sapiens_hsa00670	0.30594894

KIAA1841

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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