ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of erythrocyte differentiation (GO:0045647)	3.70475544
2	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.61382640
3	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.47092216
4	proline biosynthetic process (GO:0006561)	3.43843780
5	regulation of early endosome to late endosome transport (GO:2000641)	3.40461643
6	barbed-end actin filament capping (GO:0051016)	3.40311798
7	protein localization to endosome (GO:0036010)	3.39686586
8	COPI coating of Golgi vesicle (GO:0048205)	3.36725972
9	Golgi transport vesicle coating (GO:0048200)	3.36725972
10	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.34424386
11	regulation of extracellular matrix disassembly (GO:0010715)	3.34322738
12	NADH metabolic process (GO:0006734)	3.32426265
13	mannose metabolic process (GO:0006013)	3.29268618
14	pinocytosis (GO:0006907)	3.29234940
15	antigen processing and presentation of endogenous antigen (GO:0019883)	3.23234218
16	angiotensin maturation (GO:0002003)	3.17350300
17	urea cycle (GO:0000050)	3.13780404
18	apoptotic process involved in morphogenesis (GO:0060561)	3.09574357
19	regulation of cholesterol homeostasis (GO:2000188)	3.07254299
20	glycosphingolipid catabolic process (GO:0046479)	3.04812757
21	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.01931348
22	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.97820349
23	positive regulation by symbiont of host defense response (GO:0052509)	2.96590716
24	modulation by symbiont of host defense response (GO:0052031)	2.96590716
25	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.96590716
26	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.96590716
27	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.96590716
28	modulation by symbiont of host immune response (GO:0052553)	2.96590716
29	protein retention in ER lumen (GO:0006621)	2.95695276
30	glucose 6-phosphate metabolic process (GO:0051156)	2.94670826
31	urea metabolic process (GO:0019627)	2.94540859
32	regulation of superoxide anion generation (GO:0032928)	2.87265762
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.87243450
34	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.86147415
35	protein-lipid complex assembly (GO:0065005)	2.84824066
36	plasma lipoprotein particle assembly (GO:0034377)	2.84567321
37	proline metabolic process (GO:0006560)	2.83946117
38	very-low-density lipoprotein particle assembly (GO:0034379)	2.83553478
39	basement membrane organization (GO:0071711)	2.82745732
40	detection of bacterium (GO:0016045)	2.81816783
41	peptide catabolic process (GO:0043171)	2.79923279
42	adhesion of symbiont to host (GO:0044406)	2.79690390
43	glycolipid catabolic process (GO:0019377)	2.79649662
44	detection of other organism (GO:0098543)	2.78316872
45	positive regulation of extracellular matrix organization (GO:1903055)	2.72376787
46	response to peptidoglycan (GO:0032494)	2.67754660
47	nitrogen cycle metabolic process (GO:0071941)	2.67603573
48	negative regulation of cell killing (GO:0031342)	2.67046726
49	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.67046726
50	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.64023941
51	modulation by symbiont of host cellular process (GO:0044068)	2.62867051
52	GDP-mannose metabolic process (GO:0019673)	2.61697587
53	regulation of extracellular matrix organization (GO:1903053)	2.61491519
54	stress fiber assembly (GO:0043149)	2.61302159
55	positive regulation of lipoprotein lipase activity (GO:0051006)	2.61090226
56	positive regulation of triglyceride lipase activity (GO:0061365)	2.61090226
57	activation of Rac GTPase activity (GO:0032863)	2.60119565
58	response to laminar fluid shear stress (GO:0034616)	2.59928198
59	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.59583275
60	fructose metabolic process (GO:0006000)	2.58556454
61	negative regulation of viral release from host cell (GO:1902187)	2.58544388
62	pentose-phosphate shunt (GO:0006098)	2.57184093
63	adhesion of symbiont to host cell (GO:0044650)	2.56503076
64	virion attachment to host cell (GO:0019062)	2.56503076
65	negative regulation of fatty acid transport (GO:2000192)	2.54698214
66	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	2.54661592
67	protein carboxylation (GO:0018214)	2.53645546
68	peptidyl-glutamic acid carboxylation (GO:0017187)	2.53645546
69	NIK/NF-kappaB signaling (GO:0038061)	2.53626705
70	maternal placenta development (GO:0001893)	2.49985477
71	focal adhesion assembly (GO:0048041)	2.45324809
72	cell-substrate adherens junction assembly (GO:0007045)	2.45324809
73	oligosaccharide catabolic process (GO:0009313)	2.45248263
74	embryonic process involved in female pregnancy (GO:0060136)	2.44354921
75	diacylglycerol metabolic process (GO:0046339)	2.43419866
76	regulation of cholesterol esterification (GO:0010872)	2.42699306
77	modulation by virus of host process (GO:0019054)	2.42515660
78	positive regulation of receptor recycling (GO:0001921)	2.41797384
79	glucose catabolic process (GO:0006007)	2.40527907
80	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.40275936
81	low-density lipoprotein particle clearance (GO:0034383)	2.38975664
82	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.38903124
83	adherens junction assembly (GO:0034333)	2.36951956
84	amyloid precursor protein catabolic process (GO:0042987)	2.35251274
85	regulation of cholesterol biosynthetic process (GO:0045540)	2.34824187
86	phospholipid efflux (GO:0033700)	2.33624871
87	detection of external biotic stimulus (GO:0098581)	2.33151413
88	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.31452526
89	negative regulation of cell size (GO:0045792)	2.31158801
90	cell-substrate junction assembly (GO:0007044)	2.30923042
91	epithelial cell-cell adhesion (GO:0090136)	2.30840140
92	regulation of cholesterol metabolic process (GO:0090181)	2.30602092
93	glutamine family amino acid biosynthetic process (GO:0009084)	2.29890146
94	regulation of necrotic cell death (GO:0010939)	2.29268992
95	regulation of leukocyte degranulation (GO:0043300)	2.28688625
96	fat-soluble vitamin biosynthetic process (GO:0042362)	2.27718743
97	hyaluronan catabolic process (GO:0030214)	2.26614982
98	3-UTR-mediated mRNA stabilization (GO:0070935)	2.26011864
99	negative regulation of fibrinolysis (GO:0051918)	2.25260811
100	peptidyl-proline hydroxylation (GO:0019511)	2.24193824

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.10829266
2	VDR_21846776_ChIP-Seq_THP-1_Human	2.81723643
3	LXR_22292898_ChIP-Seq_THP-1_Human	2.81391136
4	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.72906268
5	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.52764201
6	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.47830953
7	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.45952134
8	MYC_22102868_ChIP-Seq_BL_Human	2.44732376
9	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.40630809
10	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.35489158
11	* RACK7_27058665_Chip-Seq_MCF-7_Human	2.21442189
12	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.20686577
13	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.14898407
14	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.13574560
15	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.07071548
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.95315388
17	ZNF263_19887448_ChIP-Seq_K562_Human	1.94547075
18	TCF7_22412390_ChIP-Seq_EML_Mouse	1.89987474
19	* KDM2B_26808549_Chip-Seq_DND41_Human	1.80063055
20	VDR_24763502_ChIP-Seq_THP-1_Human	1.74642055
21	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.66294332
22	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.65728412
23	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.61851075
24	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.55961980
25	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.55830987
26	* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.53486118
27	KDM2B_26808549_Chip-Seq_K562_Human	1.51611662
28	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.49106189
29	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.47867895
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.46271163
31	P68_20966046_ChIP-Seq_HELA_Human	1.45410100
32	* SA1_27219007_Chip-Seq_ERYTHROID_Human	1.44373192
33	* MAF_26560356_Chip-Seq_TH1_Human	1.44357969
34	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.42846706
35	CLOCK_20551151_ChIP-Seq_293T_Human	1.41446167
36	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.40479703
37	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.39028974
38	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.38548216
39	* KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.38355312
40	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.38081504
41	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38029783
42	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.36513866
43	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.34480668
44	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.34282270
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.34225662
46	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.33448918
47	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.30790724
48	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.30730499
49	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.30537821
50	UTX_26944678_Chip-Seq_JUKART_Human	1.28550500
51	NCOR1_26117541_ChIP-Seq_K562_Human	1.28537695
52	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27095649
53	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.27042348
54	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.26769446
55	* P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.26188780
56	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.25695829
57	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.25684965
58	BCOR_27268052_Chip-Seq_Bcells_Human	1.25662470
59	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.24567396
60	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.24467784
61	* SMC4_20622854_ChIP-Seq_HELA_Human	1.24372306
62	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.23688062
63	* MAF_26560356_Chip-Seq_TH2_Human	1.23568538
64	ATF3_27146783_Chip-Seq_COLON_Human	1.22587369
65	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.21054018
66	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.20700823
67	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.20692051
68	* CREB1_26743006_Chip-Seq_LNCaP_Human	1.19236301
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.19172711
70	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.18100480
71	BCL6_27268052_Chip-Seq_Bcells_Human	1.17058992
72	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.16906723
73	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.16865519
74	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.15890526
75	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.13015898
76	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.13002293
77	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.12983339
78	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.12599839
79	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.12194452
80	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.11601477
81	* CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.10774158
82	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.09347806
83	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.08901468
84	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.07863492
85	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.07762438
86	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.06946816
87	TP53_22127205_ChIP-Seq_IMR90_Human	1.06700176
88	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02567740
89	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.01872254
90	SPI1_23127762_ChIP-Seq_K562_Human	0.99337784
91	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.98932147
92	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.98235528
93	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.97551106
94	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.96998656
95	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.96357269
96	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.95735386
97	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.94659378
98	* SA1_27219007_Chip-Seq_Bcells_Human	0.94312712
99	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.94179124
100	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.93327535

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	3.50305514
2	MP0003705_abnormal_hypodermis_morpholog	3.46203934
3	MP0005058_abnormal_lysosome_morphology	3.46202049
4	MP0005360_urolithiasis	3.38125131
5	MP0009840_abnormal_foam_cell	3.19212264
6	MP0003191_abnormal_cellular_cholesterol	2.48936338
7	MP0008260_abnormal_autophagy	2.44373094
8	MP0003303_peritoneal_inflammation	2.39423856
9	MP0003436_decreased_susceptibility_to	2.36891435
10	MP0010234_abnormal_vibrissa_follicle	2.35431689
11	MP0002139_abnormal_hepatobiliary_system	2.26022704
12	MP0008438_abnormal_cutaneous_collagen	2.20995806
13	MP0004858_abnormal_nervous_system	2.15430058
14	MP0003172_abnormal_lysosome_physiology	2.11427287
15	MP0003566_abnormal_cell_adhesion	1.88284945
16	MP0003300_gastrointestinal_ulcer	1.87030035
17	MP0001849_ear_inflammation	1.75075386
18	MP0005409_darkened_coat_color	1.74880313
19	MP0004185_abnormal_adipocyte_glucose	1.69004900
20	MP0000858_altered_metastatic_potential	1.67467959
21	MP0000678_abnormal_parathyroid_gland	1.64552077
22	MP0009333_abnormal_splenocyte_physiolog	1.63949455
23	MP0005076_abnormal_cell_differentiation	1.63054424
24	MP0003453_abnormal_keratinocyte_physiol	1.60156924
25	MP0010155_abnormal_intestine_physiology	1.54275468
26	MP0003183_abnormal_peptide_metabolism	1.53184560
27	MP0002796_impaired_skin_barrier	1.50251757
28	MP0002877_abnormal_melanocyte_morpholog	1.48824811
29	MP0005464_abnormal_platelet_physiology	1.44580892
30	MP0000685_abnormal_immune_system	1.44195531
31	MP0005365_abnormal_bile_salt	1.42890498
32	MP0000490_abnormal_crypts_of	1.41755833
33	MP0004947_skin_inflammation	1.38057580
34	MP0002419_abnormal_innate_immunity	1.37207904
35	MP0005025_abnormal_response_to	1.35849349
36	MP0004264_abnormal_extraembryonic_tissu	1.29827156
37	MP0005257_abnormal_intraocular_pressure	1.28374966
38	MP0001533_abnormal_skeleton_physiology	1.24817547
39	MP0005023_abnormal_wound_healing	1.23992029
40	MP0005666_abnormal_adipose_tissue	1.23180166
41	MP0003091_abnormal_cell_migration	1.22941439
42	MP0005387_immune_system_phenotype	1.21284041
43	MP0001790_abnormal_immune_system	1.21284041
44	MP0001666_abnormal_nutrient_absorption	1.21058845
45	MP0005501_abnormal_skin_physiology	1.16887018
46	MP0002089_abnormal_postnatal_growth/wei	1.15203988
47	MP0001835_abnormal_antigen_presentation	1.14978783
48	MP0009379_abnormal_foot_pigmentation	1.14269290
49	MP0004272_abnormal_basement_membrane	1.13649945
50	MP0005085_abnormal_gallbladder_physiolo	1.13336688
51	MP0002998_abnormal_bone_remodeling	1.12738336
52	MP0003075_altered_response_to	1.11595440
53	MP0009278_abnormal_bone_marrow	1.06968000
54	MP0003279_aneurysm	1.06317798
55	MP0010352_gastrointestinal_tract_polyps	1.04964219
56	MP0003724_increased_susceptibility_to	1.01677000
57	MP0003329_amyloid_beta_deposits	0.99995576
58	MP0005375_adipose_tissue_phenotype	0.98976613
59	MP0006082_CNS_inflammation	0.98818054
60	MP0005000_abnormal_immune_tolerance	0.98711084
61	MP0000604_amyloidosis	0.98710955
62	MP0003828_pulmonary_edema	0.97811334
63	MP0000609_abnormal_liver_physiology	0.97379280
64	MP0004510_myositis	0.97020914
65	MP0009785_altered_susceptibility_to	0.96662453
66	MP0005166_decreased_susceptibility_to	0.94396866
67	MP0002132_abnormal_respiratory_system	0.92785466
68	MP0001958_emphysema	0.92442406
69	MP0008469_abnormal_protein_level	0.91608974
70	MP0001845_abnormal_inflammatory_respons	0.91415601
71	MP0004019_abnormal_vitamin_homeostasis	0.86961633
72	MP0003866_abnormal_defecation	0.86268015
73	MP0004233_abnormal_muscle_weight	0.85371728
74	MP0000343_altered_response_to	0.84518514
75	MP0002723_abnormal_immune_serum	0.84432656
76	MP0002249_abnormal_larynx_morphology	0.84028082
77	MP0001819_abnormal_immune_cell	0.83962046
78	MP0002420_abnormal_adaptive_immunity	0.83677417
79	MP0000477_abnormal_intestine_morphology	0.83634405
80	MP0002148_abnormal_hypersensitivity_rea	0.83430167
81	MP0002452_abnormal_antigen_presenting	0.83335525
82	MP0000767_abnormal_smooth_muscle	0.80828993
83	MP0010329_abnormal_lipoprotein_level	0.80765082
84	MP0002060_abnormal_skin_morphology	0.80607667
85	MP0001873_stomach_inflammation	0.79907755
86	MP0001800_abnormal_humoral_immune	0.78599389
87	MP0002396_abnormal_hematopoietic_system	0.77564133
88	MP0000003_abnormal_adipose_tissue	0.75944515
89	MP0000681_abnormal_thyroid_gland	0.74692988
90	MP0009931_abnormal_skin_appearance	0.74671110
91	MP0009643_abnormal_urine_homeostasis	0.74490633
92	MP0003448_altered_tumor_morphology	0.73237387
93	MP0003763_abnormal_thymus_physiology	0.73203149
94	MP0001663_abnormal_digestive_system	0.73086284
95	MP0003123_paternal_imprinting	0.72783389
96	MP0000747_muscle_weakness	0.72367218
97	MP0005319_abnormal_enzyme/_coenzyme	0.71658466
98	MP0001915_intracranial_hemorrhage	0.71201955
99	MP0000249_abnormal_blood_vessel	0.71197509
100	MP0005165_increased_susceptibility_to	0.70750518

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	3.31150590
2	Eczematoid dermatitis (HP:0000976)	3.21143025
3	Systemic lupus erythematosus (HP:0002725)	3.16205800
4	Protrusio acetabuli (HP:0003179)	3.08850340
5	Premature rupture of membranes (HP:0001788)	3.01998907
6	Vertebral compression fractures (HP:0002953)	2.93197927
7	Hemorrhage of the eye (HP:0011885)	2.91019584
8	Abnormality of macrophages (HP:0004311)	2.70394421
9	Malnutrition (HP:0004395)	2.69568117
10	Achilles tendon contracture (HP:0001771)	2.65128661
11	Abnormality of the Achilles tendon (HP:0005109)	2.60037866
12	Abnormality of complement system (HP:0005339)	2.56155768
13	Thin bony cortex (HP:0002753)	2.53500854
14	Flat acetabular roof (HP:0003180)	2.49798973
15	Cellulitis (HP:0100658)	2.42055865
16	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.40257427
17	Purpura (HP:0000979)	2.39661164
18	Increased connective tissue (HP:0009025)	2.39213525
19	Xanthomatosis (HP:0000991)	2.38731106
20	Dysostosis multiplex (HP:0000943)	2.37815841
21	Cerebral aneurysm (HP:0004944)	2.31315528
22	Abnormality of glycolipid metabolism (HP:0010969)	2.31003495
23	Abnormality of liposaccharide metabolism (HP:0010968)	2.31003495
24	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.31003495
25	Distal lower limb muscle weakness (HP:0009053)	2.30816405
26	Recurrent abscess formation (HP:0002722)	2.29656870
27	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.25924031
28	Distal lower limb amyotrophy (HP:0008944)	2.22508615
29	Recurrent gram-negative bacterial infections (HP:0005420)	2.16523246
30	Increased cerebral lipofuscin (HP:0011813)	2.14720622
31	Axonal loss (HP:0003447)	2.14244099
32	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.13597825
33	Gingivitis (HP:0000230)	2.12055404
34	Cervical subluxation (HP:0003308)	2.11889015
35	Polycythemia (HP:0001901)	2.10858520
36	Myopathic facies (HP:0002058)	2.09924169
37	Recurrent bacterial skin infections (HP:0005406)	2.09505095
38	Complement deficiency (HP:0004431)	2.07673835
39	Disproportionate tall stature (HP:0001519)	2.06782305
40	Mucopolysacchariduria (HP:0008155)	2.06493479
41	Urinary glycosaminoglycan excretion (HP:0003541)	2.06493479
42	Abnormal gallbladder physiology (HP:0012438)	2.05183886
43	Cholecystitis (HP:0001082)	2.05183886
44	Distal upper limb amyotrophy (HP:0007149)	2.04006521
45	Upper limb amyotrophy (HP:0009129)	2.04006521
46	Obstructive lung disease (HP:0006536)	2.03776160
47	Chronic obstructive pulmonary disease (HP:0006510)	2.03776160
48	Abnormality of polysaccharide metabolism (HP:0011012)	2.01882668
49	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.01882668
50	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.01882668
51	Amyloidosis (HP:0011034)	1.99083311
52	Abnormality of carpal bone ossification (HP:0006257)	1.98322078
53	Glomerulonephritis (HP:0000099)	1.93753312
54	Colitis (HP:0002583)	1.93523612
55	Hyperparathyroidism (HP:0000843)	1.93317691
56	Ulnar bowing (HP:0003031)	1.93202934
57	Loss of speech (HP:0002371)	1.92761468
58	Blue sclerae (HP:0000592)	1.92294865
59	Stridor (HP:0010307)	1.92104589
60	Emphysema (HP:0002097)	1.91653328
61	Bulbar palsy (HP:0001283)	1.91072933
62	Bone pain (HP:0002653)	1.90866674
63	Increased variability in muscle fiber diameter (HP:0003557)	1.90465102
64	Abnormality of the thoracic spine (HP:0100711)	1.89150104
65	Hyperacusis (HP:0010780)	1.88840842
66	Polygenic inheritance (HP:0010982)	1.88361775
67	Fragile skin (HP:0001030)	1.88254439
68	Hypertriglyceridemia (HP:0002155)	1.87014401
69	Abnormal ossification of hand bones (HP:0005921)	1.86382803
70	Ileus (HP:0002595)	1.85482287
71	Segmental peripheral demyelination/remyelination (HP:0003481)	1.84914807
72	Hypertensive crisis (HP:0100735)	1.84084975
73	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.83109356
74	Myocardial infarction (HP:0001658)	1.81036953
75	Aneurysm (HP:0002617)	1.80723287
76	Pathologic fracture (HP:0002756)	1.80643542
77	Abnormality of skeletal muscle fiber size (HP:0012084)	1.78020930
78	Vacuolated lymphocytes (HP:0001922)	1.77216217
79	Gastrointestinal dysmotility (HP:0002579)	1.76721830
80	Gastrointestinal stroma tumor (HP:0100723)	1.75956021
81	Abdominal distention (HP:0003270)	1.75230586
82	Abnormality of alkaline phosphatase activity (HP:0004379)	1.75069344
83	Gastrointestinal inflammation (HP:0004386)	1.74350831
84	Increased IgE level (HP:0003212)	1.74021978
85	Mildly elevated creatine phosphokinase (HP:0008180)	1.72085571
86	Abnormal enzyme/coenzyme activity (HP:0012379)	1.71361866
87	Elevated alkaline phosphatase (HP:0003155)	1.70722225
88	Gastrointestinal infarctions (HP:0005244)	1.69960913
89	Hypophosphatemia (HP:0002148)	1.68726063
90	Thoracic kyphosis (HP:0002942)	1.68623698
91	Asymmetric septal hypertrophy (HP:0001670)	1.67777293
92	Increased serum ferritin (HP:0003281)	1.67593659
93	Abnormality of the distal phalanges of the toes (HP:0010182)	1.66571834
94	Upper motor neuron abnormality (HP:0002127)	1.65704984
95	Petechiae (HP:0000967)	1.64407509
96	Joint hemorrhage (HP:0005261)	1.64065939
97	Easy fatigability (HP:0003388)	1.63409417
98	Abnormality of the nasal mucosa (HP:0000433)	1.63267434
99	Mediastinal lymphadenopathy (HP:0100721)	1.61935485
100	Hydroxyprolinuria (HP:0003080)	1.61718475

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.57128335
2	ERN1	4.25630458
3	SMG1	3.18510016
4	PRPF4B	3.06988904
5	SIK1	2.72222598
6	IRAK3	2.70946282
7	ICK	2.41134930
8	MAP2K3	2.26428921
9	EPHA2	2.21372036
10	RIPK1	2.12036342
11	FGFR4	2.02200847
12	EEF2K	1.91346834
13	NME2	1.86264629
14	MAP3K3	1.80525552
15	MAP3K11	1.65330421
16	RIPK4	1.63681475
17	PKN2	1.59038092
18	MAP3K10	1.58578262
19	TAOK2	1.57036910
20	MST1R	1.55615432
21	MAP4K1	1.52075209
22	TTN	1.49631760
23	TESK2	1.43812187
24	IRAK4	1.42542266
25	TESK1	1.41435003
26	TAOK1	1.39473901
27	TYK2	1.36758829
28	KSR2	1.36745380
29	MAP3K1	1.33756276
30	MAP3K13	1.33058652
31	CDK12	1.32184156
32	PTK6	1.30418670
33	EPHB1	1.28835988
34	PAK4	1.24389850
35	ARAF	1.19847504
36	PRKD2	1.18427302
37	PDPK1	1.15241837
38	TBK1	1.14865416
39	PDGFRA	1.04326617
40	CDC42BPA	1.00935909
41	PRKG2	0.96784857
42	ZAP70	0.95962640
43	CSK	0.93439226
44	MAP3K8	0.93122804
45	BLK	0.92123635
46	PTK2	0.91395205
47	GRK6	0.88817042
48	LMTK2	0.86845979
49	MAP3K2	0.86003245
50	LRRK2	0.85630758
51	BMX	0.85134238
52	DDR2	0.85043983
53	MARK2	0.82345942
54	MAPK11	0.78237800
55	MTOR	0.74125700
56	IRAK2	0.72551523
57	MAP3K6	0.70553925
58	BRAF	0.70296830
59	PDK1	0.68992114
60	RPS6KA2	0.66601754
61	JAK3	0.64124394
62	EPHB2	0.62673610
63	RPS6KC1	0.61948075
64	RPS6KL1	0.61948075
65	PRKD3	0.61853355
66	CDK4	0.60151041
67	TGFBR2	0.60055232
68	PIM2	0.59678400
69	TNK2	0.59197662
70	MAP2K2	0.57234701
71	MAP3K14	0.56979709
72	DYRK1B	0.56084294
73	MOS	0.53377959
74	RET	0.52450486
75	FGFR3	0.51390879
76	BTK	0.49994773
77	CDK7	0.49755042
78	ABL2	0.49002769
79	MAPK12	0.47966840
80	STK10	0.47362297
81	HIPK2	0.45513122
82	ILK	0.44241527
83	CSF1R	0.44018287
84	MAPKAPK2	0.43931253
85	HCK	0.43300231
86	FGR	0.43268129
87	DMPK	0.39887239
88	STK38	0.39327319
89	RPS6KA6	0.38357627
90	MET	0.37390843
91	MATK	0.36305231
92	MAP3K7	0.35210660
93	KDR	0.34238863
94	LATS2	0.33917448
95	SIK2	0.33120302
96	TYRO3	0.31519375
97	MAP2K6	0.29796677
98	PAK1	0.29723427
99	FES	0.28405987
100	SIK3	0.27734355

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	3.37090040
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.97431511
3	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.92709556
4	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.18552629
5	Galactose metabolism_Homo sapiens_hsa00052	2.10811587
6	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.06049726
7	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.94531742
8	Pentose phosphate pathway_Homo sapiens_hsa00030	1.76870532
9	Acute myeloid leukemia_Homo sapiens_hsa05221	1.62385465
10	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.60263090
11	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.51016282
12	Arginine biosynthesis_Homo sapiens_hsa00220	1.49738668
13	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.47451525
14	Bladder cancer_Homo sapiens_hsa05219	1.45817735
15	Prion diseases_Homo sapiens_hsa05020	1.45161069
16	Leishmaniasis_Homo sapiens_hsa05140	1.42216237
17	Renin-angiotensin system_Homo sapiens_hsa04614	1.42040368
18	Osteoclast differentiation_Homo sapiens_hsa04380	1.39977026
19	Lysosome_Homo sapiens_hsa04142	1.33645558
20	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.31311474
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30959972
22	Notch signaling pathway_Homo sapiens_hsa04330	1.30673526
23	Sulfur relay system_Homo sapiens_hsa04122	1.29637540
24	Complement and coagulation cascades_Homo sapiens_hsa04610	1.27996524
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.25945076
26	Non-small cell lung cancer_Homo sapiens_hsa05223	1.25106285
27	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.22705567
28	VEGF signaling pathway_Homo sapiens_hsa04370	1.16232002
29	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.15213087
30	Pancreatic cancer_Homo sapiens_hsa05212	1.12836221
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.12662566
32	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.12495021
33	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.07007319
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.06513331
35	Toxoplasmosis_Homo sapiens_hsa05145	1.03604929
36	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.02094035
37	Hepatitis C_Homo sapiens_hsa05160	1.00406635
38	PPAR signaling pathway_Homo sapiens_hsa03320	1.00103414
39	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.94233301
40	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.94228538
41	Tuberculosis_Homo sapiens_hsa05152	0.91010992
42	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.90278685
43	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.88911539
44	Amoebiasis_Homo sapiens_hsa05146	0.88493069
45	Insulin signaling pathway_Homo sapiens_hsa04910	0.88019708
46	Insulin resistance_Homo sapiens_hsa04931	0.87593425
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.87166763
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86571315
49	Renal cell carcinoma_Homo sapiens_hsa05211	0.84053252
50	Pertussis_Homo sapiens_hsa05133	0.84045197
51	Influenza A_Homo sapiens_hsa05164	0.83210810
52	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.82773469
53	Thyroid cancer_Homo sapiens_hsa05216	0.82210199
54	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.81450400
55	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.81181876
56	TNF signaling pathway_Homo sapiens_hsa04668	0.78447196
57	Carbon metabolism_Homo sapiens_hsa01200	0.78100056
58	Apoptosis_Homo sapiens_hsa04210	0.77986389
59	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.75969670
60	Vibrio cholerae infection_Homo sapiens_hsa05110	0.75821761
61	Viral myocarditis_Homo sapiens_hsa05416	0.74787936
62	Salmonella infection_Homo sapiens_hsa05132	0.74224778
63	Sulfur metabolism_Homo sapiens_hsa00920	0.73927361
64	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.73342107
65	Shigellosis_Homo sapiens_hsa05131	0.73165404
66	Bile secretion_Homo sapiens_hsa04976	0.71944205
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71483905
68	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.70053356
69	Hepatitis B_Homo sapiens_hsa05161	0.69722521
70	Endometrial cancer_Homo sapiens_hsa05213	0.69191954
71	Endocytosis_Homo sapiens_hsa04144	0.68527844
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.68357578
73	Phagosome_Homo sapiens_hsa04145	0.65608180
74	Focal adhesion_Homo sapiens_hsa04510	0.65422240
75	Protein digestion and absorption_Homo sapiens_hsa04974	0.63288702
76	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.62327365
77	Proteoglycans in cancer_Homo sapiens_hsa05205	0.61161595
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.60080692
79	Malaria_Homo sapiens_hsa05144	0.59804823
80	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.59784591
81	Small cell lung cancer_Homo sapiens_hsa05222	0.59450904
82	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59154841
83	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.57883072
84	AMPK signaling pathway_Homo sapiens_hsa04152	0.57846067
85	GnRH signaling pathway_Homo sapiens_hsa04912	0.57367549
86	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.57040296
87	Chemokine signaling pathway_Homo sapiens_hsa04062	0.56337099
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56263498
89	Viral carcinogenesis_Homo sapiens_hsa05203	0.53785101
90	Herpes simplex infection_Homo sapiens_hsa05168	0.53002126
91	Allograft rejection_Homo sapiens_hsa05330	0.52756348
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51570493
93	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.51395448
94	Histidine metabolism_Homo sapiens_hsa00340	0.49869495
95	Glioma_Homo sapiens_hsa05214	0.49614949
96	Mineral absorption_Homo sapiens_hsa04978	0.47860427
97	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.46940140
98	Measles_Homo sapiens_hsa05162	0.46889246
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46784474
100	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.46618378

KIAA2013

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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