KIAA2022

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: An inversion on the X chromosome which disrupts this gene and a G-protein coupled purinergic receptor gene located in the pseudoautosomal region of the X chromosome has been linked to X linked mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.85417021
2presynaptic membrane assembly (GO:0097105)5.63938252
3neuron cell-cell adhesion (GO:0007158)5.19019660
4postsynaptic membrane organization (GO:0001941)5.02867817
5presynaptic membrane organization (GO:0097090)4.95268653
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.89307639
7nucleobase catabolic process (GO:0046113)4.86161740
8auditory behavior (GO:0031223)4.43645156
9neuron recognition (GO:0008038)4.34858816
10protein localization to synapse (GO:0035418)4.32843808
11glutamate receptor signaling pathway (GO:0007215)4.25086083
12central nervous system projection neuron axonogenesis (GO:0021952)4.23202894
13axonal fasciculation (GO:0007413)4.22792059
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.21303280
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14701519
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11724531
17gamma-aminobutyric acid transport (GO:0015812)4.08512820
18vocalization behavior (GO:0071625)4.08106508
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06780517
20synaptic vesicle maturation (GO:0016188)3.98764348
21neurotransmitter-gated ion channel clustering (GO:0072578)3.95240061
22startle response (GO:0001964)3.91429149
23synaptic transmission, glutamatergic (GO:0035249)3.90383613
24mechanosensory behavior (GO:0007638)3.86020899
25neuron-neuron synaptic transmission (GO:0007270)3.73526496
26establishment of mitochondrion localization (GO:0051654)3.70667502
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59623008
28synaptic vesicle exocytosis (GO:0016079)3.59358063
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.58458159
30behavioral response to nicotine (GO:0035095)3.55402525
31synapse assembly (GO:0007416)3.52084264
32membrane depolarization during action potential (GO:0086010)3.48329038
33dendrite morphogenesis (GO:0048813)3.44194000
34central nervous system neuron axonogenesis (GO:0021955)3.44060125
35cell migration in hindbrain (GO:0021535)3.42975471
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41872103
37response to auditory stimulus (GO:0010996)3.41654195
38transmission of nerve impulse (GO:0019226)3.41136648
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.40984683
40exploration behavior (GO:0035640)3.40623931
41dendritic spine morphogenesis (GO:0060997)3.40561967
42glutamate secretion (GO:0014047)3.27629358
43layer formation in cerebral cortex (GO:0021819)3.25267936
44regulation of feeding behavior (GO:0060259)3.25217554
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.24487434
46neurotransmitter secretion (GO:0007269)3.22542929
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.21018015
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19536986
49neuronal action potential (GO:0019228)3.19137213
50neuronal action potential propagation (GO:0019227)3.18197019
51righting reflex (GO:0060013)3.16913116
52establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16127581
53mitochondrion transport along microtubule (GO:0047497)3.16127581
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15365051
55behavioral response to ethanol (GO:0048149)3.14491756
56positive regulation of synapse assembly (GO:0051965)3.13823043
57positive regulation of membrane potential (GO:0045838)3.12647062
58negative regulation of dendrite development (GO:2000171)3.11239693
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09591095
60regulation of synapse structural plasticity (GO:0051823)3.01358302
61cerebral cortex radially oriented cell migration (GO:0021799)2.99571615
62behavioral fear response (GO:0001662)2.97422691
63behavioral defense response (GO:0002209)2.97422691
64regulation of postsynaptic membrane potential (GO:0060078)2.97195515
65short-term memory (GO:0007614)2.96303473
66membrane depolarization (GO:0051899)2.95876102
67glycosphingolipid biosynthetic process (GO:0006688)2.95461746
68regulation of dendritic spine morphogenesis (GO:0061001)2.95001568
69hindbrain development (GO:0030902)2.94511364
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93226307
71positive regulation of potassium ion transmembrane transport (GO:1901381)2.92290873
72regulation of glutamate receptor signaling pathway (GO:1900449)2.89564406
73positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.88100627
74fear response (GO:0042596)2.85506819
75regulation of respiratory system process (GO:0044065)2.84671020
76synaptic vesicle docking involved in exocytosis (GO:0016081)2.84465172
77regulation of dendritic spine development (GO:0060998)2.83802722
78positive regulation of dendritic spine morphogenesis (GO:0061003)2.82632341
79positive regulation of synapse maturation (GO:0090129)2.81830439
80adult walking behavior (GO:0007628)2.80600317
81positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.80144190
82regulation of synaptic vesicle exocytosis (GO:2000300)2.79288488
83response to histamine (GO:0034776)2.79170196
84behavioral response to cocaine (GO:0048148)2.78957235
85regulation of action potential (GO:0098900)2.78465181
86adult behavior (GO:0030534)2.78253623
87synapse organization (GO:0050808)2.77624161
88membrane assembly (GO:0071709)2.71761414
89membrane hyperpolarization (GO:0060081)2.71640712
90hippocampus development (GO:0021766)2.71514895
91positive regulation of dendritic spine development (GO:0060999)2.70515835
92atrial cardiac muscle cell action potential (GO:0086014)2.70300171
93nonmotile primary cilium assembly (GO:0035058)2.70253364
94regulation of synapse assembly (GO:0051963)2.70218482
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.68511920
96regulation of respiratory gaseous exchange (GO:0043576)2.67367946
97adaptation of signaling pathway (GO:0023058)2.66107366
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.65686928
99regulation of calcium ion-dependent exocytosis (GO:0017158)2.64961975
100regulation of synaptic vesicle transport (GO:1902803)2.62893885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22000212
2GBX2_23144817_ChIP-Seq_PC3_Human3.97596065
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.15300736
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.03133831
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.89796983
6IGF1R_20145208_ChIP-Seq_DFB_Human2.67005556
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62064921
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.42648663
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41421839
10REST_21632747_ChIP-Seq_MESCs_Mouse2.40666232
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34657525
12TAF15_26573619_Chip-Seq_HEK293_Human2.33396958
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30489275
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.24941953
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20679166
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.19523127
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15700657
18ZNF274_21170338_ChIP-Seq_K562_Hela2.09497683
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09457725
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08587296
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08397328
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04232049
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04073555
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02600127
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92675103
26FUS_26573619_Chip-Seq_HEK293_Human1.88327703
27P300_19829295_ChIP-Seq_ESCs_Human1.86866181
28SMAD4_21799915_ChIP-Seq_A2780_Human1.82900965
29RNF2_27304074_Chip-Seq_NSC_Mouse1.81366936
30AR_21572438_ChIP-Seq_LNCaP_Human1.81189523
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.80587562
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79155738
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77862901
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.77184632
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72311369
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.69863898
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67495366
38DROSHA_22980978_ChIP-Seq_HELA_Human1.65696617
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65392919
40VDR_22108803_ChIP-Seq_LS180_Human1.64342932
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63813028
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62298177
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61668505
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.58828433
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58310917
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57715528
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57715528
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.55269764
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.55053684
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54109986
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53742096
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53694034
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51268958
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.49763804
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48455059
56STAT3_23295773_ChIP-Seq_U87_Human1.48277596
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48130436
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48130436
59EWS_26573619_Chip-Seq_HEK293_Human1.45070565
60AR_25329375_ChIP-Seq_VCAP_Human1.44962487
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40722808
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39094517
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37842212
64TCF4_23295773_ChIP-Seq_U87_Human1.35935358
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33499467
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32133344
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30764214
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30369303
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27244036
70ER_23166858_ChIP-Seq_MCF-7_Human1.26730810
71BCAT_22108803_ChIP-Seq_LS180_Human1.25843091
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.23737561
73RUNX2_22187159_ChIP-Seq_PCA_Human1.21485241
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21373274
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.19304701
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.19253203
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18137873
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17171569
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16792138
80CBP_20019798_ChIP-Seq_JUKART_Human1.16792138
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16365274
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14494431
83LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14458459
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14435247
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12637269
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12353660
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.12245647
88AR_19668381_ChIP-Seq_PC3_Human1.09731453
89KDM2B_26808549_Chip-Seq_REH_Human1.09433266
90SOX9_26525672_Chip-Seq_HEART_Mouse1.08693086
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.07377727
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06539825
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05555134
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.05522327
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02985341
96JUN_21703547_ChIP-Seq_K562_Human1.02748242
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01610681
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.01397197
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01019029
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00724405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.52648604
2MP0003880_abnormal_central_pattern3.63065290
3MP0004270_analgesia3.61680456
4MP0003635_abnormal_synaptic_transmissio3.10454110
5MP0005423_abnormal_somatic_nervous3.08656718
6MP0009745_abnormal_behavioral_response2.70700553
7MP0000778_abnormal_nervous_system2.68758296
8MP0009046_muscle_twitch2.66183789
9MP0002822_catalepsy2.64052041
10MP0002063_abnormal_learning/memory/cond2.62157569
11MP0002735_abnormal_chemical_nociception2.61086613
12MP0000569_abnormal_digit_pigmentation2.56941437
13MP0002064_seizures2.48875999
14MP0001968_abnormal_touch/_nociception2.46092968
15MP0002572_abnormal_emotion/affect_behav2.41314282
16MP0003787_abnormal_imprinting2.40957560
17MP0002272_abnormal_nervous_system2.39413164
18MP0003122_maternal_imprinting2.36093250
19MP0002734_abnormal_mechanical_nocicepti2.34390320
20MP0002736_abnormal_nociception_after2.20050504
21MP0001486_abnormal_startle_reflex2.16922042
22MP0001529_abnormal_vocalization2.09728230
23MP0001984_abnormal_olfaction2.05382997
24MP0003121_genomic_imprinting1.90052192
25MP0002067_abnormal_sensory_capabilities1.88347911
26MP0005386_behavior/neurological_phenoty1.84530414
27MP0004924_abnormal_behavior1.84530414
28MP0006276_abnormal_autonomic_nervous1.80459864
29MP0001970_abnormal_pain_threshold1.79603510
30MP0002638_abnormal_pupillary_reflex1.75532625
31MP0002557_abnormal_social/conspecific_i1.74365262
32MP0002733_abnormal_thermal_nociception1.73925427
33MP0001440_abnormal_grooming_behavior1.68034085
34MP0008877_abnormal_DNA_methylation1.64952375
35MP0002184_abnormal_innervation1.64699884
36MP0000955_abnormal_spinal_cord1.62851341
37MP0004811_abnormal_neuron_physiology1.59505612
38MP0002882_abnormal_neuron_morphology1.53204748
39MP0004885_abnormal_endolymph1.53070330
40MP0004742_abnormal_vestibular_system1.50010799
41MP0005645_abnormal_hypothalamus_physiol1.48572389
42MP0001905_abnormal_dopamine_level1.46655324
43MP0002909_abnormal_adrenal_gland1.39316220
44MP0001188_hyperpigmentation1.37288528
45MP0004142_abnormal_muscle_tone1.36877168
46MP0001501_abnormal_sleep_pattern1.33397693
47MP0005551_abnormal_eye_electrophysiolog1.32367447
48MP0000631_abnormal_neuroendocrine_gland1.32306228
49MP0002152_abnormal_brain_morphology1.27680354
50MP0005187_abnormal_penis_morphology1.27356342
51MP0005646_abnormal_pituitary_gland1.27146251
52MP0004133_heterotaxia1.26446934
53MP0002066_abnormal_motor_capabilities/c1.26058751
54MP0003283_abnormal_digestive_organ1.25638212
55MP0008569_lethality_at_weaning1.23412441
56MP0001986_abnormal_taste_sensitivity1.23221241
57MP0001502_abnormal_circadian_rhythm1.20830080
58MP0003890_abnormal_embryonic-extraembry1.15100016
59MP0002102_abnormal_ear_morphology1.14219173
60MP0002752_abnormal_somatic_nervous1.06625376
61MP0002751_abnormal_autonomic_nervous1.06271061
62MP0002069_abnormal_eating/drinking_beha1.05024877
63MP0003633_abnormal_nervous_system1.03685546
64MP0000566_synostosis0.98874984
65MP0004043_abnormal_pH_regulation0.94899582
66MP0002229_neurodegeneration0.94835280
67MP0001177_atelectasis0.94533872
68MP0003631_nervous_system_phenotype0.94345300
69MP0002234_abnormal_pharynx_morphology0.94152318
70MP0005253_abnormal_eye_physiology0.93787669
71MP0003861_abnormal_nervous_system0.93597377
72MP0010386_abnormal_urinary_bladder0.93045433
73MP0005499_abnormal_olfactory_system0.91767412
74MP0005394_taste/olfaction_phenotype0.91767412
75MP0008872_abnormal_physiological_respon0.88641968
76MP0000026_abnormal_inner_ear0.88022669
77MP0002928_abnormal_bile_duct0.86295937
78MP0006072_abnormal_retinal_apoptosis0.84943189
79MP0003123_paternal_imprinting0.84829193
80MP0001963_abnormal_hearing_physiology0.81718183
81MP0003879_abnormal_hair_cell0.81279345
82MP0003329_amyloid_beta_deposits0.80743035
83MP0003632_abnormal_nervous_system0.77908922
84MP0003119_abnormal_digestive_system0.75745658
85MP0005195_abnormal_posterior_eye0.75464941
86MP0002082_postnatal_lethality0.75220759
87MP0010770_preweaning_lethality0.75220759
88MP0001485_abnormal_pinna_reflex0.75070584
89MP0004145_abnormal_muscle_electrophysio0.72953696
90MP0006292_abnormal_olfactory_placode0.72573831
91MP0001299_abnormal_eye_distance/0.71400201
92MP0010769_abnormal_survival0.69910225
93MP0000427_abnormal_hair_cycle0.69355871
94MP0003195_calcinosis0.68948330
95MP0010768_mortality/aging0.66578104
96MP0002081_perinatal_lethality0.65910393
97MP0005367_renal/urinary_system_phenotyp0.63263691
98MP0000516_abnormal_urinary_system0.63263691
99MP0001943_abnormal_respiration0.62158035
100MP0003634_abnormal_glial_cell0.61146763

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.58814829
2Hyperventilation (HP:0002883)4.94425758
3Focal seizures (HP:0007359)4.59180445
4Febrile seizures (HP:0002373)4.47972225
5Myokymia (HP:0002411)4.20430487
6Drooling (HP:0002307)3.98357883
7Epileptic encephalopathy (HP:0200134)3.95099236
8Limb dystonia (HP:0002451)3.89417957
9Atonic seizures (HP:0010819)3.85550286
10Excessive salivation (HP:0003781)3.68724625
11Broad-based gait (HP:0002136)3.68518316
12Progressive cerebellar ataxia (HP:0002073)3.45005264
13Dialeptic seizures (HP:0011146)3.38189360
14Action tremor (HP:0002345)3.35074406
15Generalized tonic-clonic seizures (HP:0002069)3.29404810
16Absent speech (HP:0001344)3.19844963
17Absence seizures (HP:0002121)3.15588558
18Gait imbalance (HP:0002141)3.13659899
19Lissencephaly (HP:0001339)3.09578236
20Polyphagia (HP:0002591)3.06172592
21Hemiparesis (HP:0001269)2.97573284
22* Epileptiform EEG discharges (HP:0011182)2.90364527
23Protruding tongue (HP:0010808)2.81097765
24Genetic anticipation (HP:0003743)2.80617025
25* EEG with generalized epileptiform discharges (HP:0011198)2.80497141
26* Hypsarrhythmia (HP:0002521)2.75891969
27Nephronophthisis (HP:0000090)2.60031184
28Retinal dysplasia (HP:0007973)2.58655943
29Medial flaring of the eyebrow (HP:0010747)2.58084805
30Pachygyria (HP:0001302)2.57476925
31Abnormality of the corticospinal tract (HP:0002492)2.50920794
32Hypothermia (HP:0002045)2.48564378
33Agitation (HP:0000713)2.48525887
34Congenital primary aphakia (HP:0007707)2.43704831
35Megalencephaly (HP:0001355)2.42859287
36Nephrogenic diabetes insipidus (HP:0009806)2.40054564
37Molar tooth sign on MRI (HP:0002419)2.37794400
38Abnormality of midbrain morphology (HP:0002418)2.37794400
39True hermaphroditism (HP:0010459)2.35996962
40Chronic hepatic failure (HP:0100626)2.35909482
41Inability to walk (HP:0002540)2.35885643
42Abnormal eating behavior (HP:0100738)2.35008880
43Volvulus (HP:0002580)2.31365732
44Pancreatic cysts (HP:0001737)2.30324602
45Type II lissencephaly (HP:0007260)2.27862133
46Urinary urgency (HP:0000012)2.27570600
47Pancreatic fibrosis (HP:0100732)2.27434755
48Gaze-evoked nystagmus (HP:0000640)2.26750760
49Urinary bladder sphincter dysfunction (HP:0002839)2.26652970
50Spastic gait (HP:0002064)2.21115177
51Hepatoblastoma (HP:0002884)2.20731178
52Abnormality of salivation (HP:0100755)2.19440336
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17845407
54Hypoplasia of the brainstem (HP:0002365)2.17845407
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.17508684
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17508684
57Amyotrophic lateral sclerosis (HP:0007354)2.15548985
58Fetal akinesia sequence (HP:0001989)2.14779396
59Abnormality of the labia minora (HP:0012880)2.14142784
60Abnormality of the renal medulla (HP:0100957)2.11877085
61Genital tract atresia (HP:0001827)2.09447301
62Specific learning disability (HP:0001328)2.07202527
63Mutism (HP:0002300)2.06386916
64Amblyopia (HP:0000646)2.05243111
65Widely spaced teeth (HP:0000687)2.04379138
66Impaired vibration sensation in the lower limbs (HP:0002166)2.03573597
67Morphological abnormality of the pyramidal tract (HP:0002062)2.02220000
68Vaginal atresia (HP:0000148)2.01746223
69Intellectual disability, severe (HP:0010864)1.99744512
70Spastic tetraplegia (HP:0002510)1.99531025
71Exotropia (HP:0000577)1.97213290
72Dysdiadochokinesis (HP:0002075)1.94679064
73Truncal ataxia (HP:0002078)1.89791516
74Status epilepticus (HP:0002133)1.86990101
75Progressive inability to walk (HP:0002505)1.86808083
76* Esotropia (HP:0000565)1.85271257
77Oligodactyly (hands) (HP:0001180)1.84776055
78Papillary thyroid carcinoma (HP:0002895)1.84628444
79Hypoplasia of the corpus callosum (HP:0002079)1.84460356
80Failure to thrive in infancy (HP:0001531)1.84132151
81Narrow forehead (HP:0000341)1.83072054
82Poor coordination (HP:0002370)1.79529901
83Congenital stationary night blindness (HP:0007642)1.78153343
84Generalized myoclonic seizures (HP:0002123)1.77826449
85Ankle clonus (HP:0011448)1.77224646
86Akinesia (HP:0002304)1.75694880
87Postaxial hand polydactyly (HP:0001162)1.74527544
88Cortical dysplasia (HP:0002539)1.73588371
89Neuroendocrine neoplasm (HP:0100634)1.72668123
90Intellectual disability, progressive (HP:0006887)1.70878411
91Abnormality of the metopic suture (HP:0005556)1.70210319
92Pheochromocytoma (HP:0002666)1.67418924
93Intestinal atresia (HP:0011100)1.67371351
94Sleep apnea (HP:0010535)1.66751447
95Polymicrogyria (HP:0002126)1.64435839
96Dyskinesia (HP:0100660)1.63174784
97Paraplegia (HP:0010550)1.63060956
98Hemiplegia (HP:0002301)1.62459064
99Lower limb muscle weakness (HP:0007340)1.59782611
100Large earlobe (HP:0009748)1.56682354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.99322395
2CASK5.76371228
3MAP3K42.99489492
4MAPK132.79625922
5NTRK32.75849419
6PNCK2.62901332
7NTRK22.52723658
8FRK2.51726326
9SIK22.43364944
10MAP2K72.33819372
11EPHA42.17446807
12WNK32.11014078
13TNIK2.03486685
14DYRK21.97276863
15MAP4K21.93431037
16BCR1.69979664
17PRKCG1.50716570
18UHMK11.46734252
19MINK11.42975065
20CSNK1G21.42856823
21MAP2K41.37029135
22CCNB11.36978656
23ERBB31.35372763
24SGK2231.34506272
25SGK4941.34506272
26SGK21.27679945
27PHKG11.24382603
28PHKG21.24382603
29CDK191.22079008
30EPHA31.17546507
31PAK31.16511150
32DAPK21.16067762
33CDK51.05221830
34MAP3K91.01835754
35ADRBK21.00683412
36BMPR1B1.00287504
37CSNK1G31.00285039
38CSNK1G10.95970091
39CSNK1A1L0.95165514
40PRKCZ0.93314871
41MKNK20.92867697
42PKN10.91730168
43PRKD30.90446590
44DYRK1A0.88015741
45PAK60.87306086
46PINK10.87017297
47PRKCE0.84630230
48CAMK2A0.84613454
49CAMK2B0.81500815
50PLK20.79891678
51OXSR10.77895580
52TRIM280.72078653
53INSRR0.70121586
54CAMKK20.68343257
55KSR10.66482281
56SGK10.66329728
57CAMKK10.65112851
58TYRO30.64600517
59FGFR20.64005479
60MAPK150.61398745
61SGK30.60078335
62BRD40.59317229
63STK110.56412186
64MAP3K60.55869130
65STK38L0.55536947
66GRK10.55225955
67PRKCH0.52523943
68CAMK40.51803847
69NTRK10.50169638
70CDK30.49415760
71CDK140.48733762
72CDK180.48045591
73AKT30.47879265
74TAOK10.47360530
75CAMK1G0.46455351
76PASK0.45810372
77CDK150.45427477
78PRKAA10.44653567
79CSNK1D0.44277914
80EPHB20.43083749
81TSSK60.42489469
82MAPKAPK50.42177658
83DYRK30.42005146
84WEE10.41269549
85PRKACA0.40626053
86CDK11A0.39870330
87CSNK1E0.38300532
88DYRK1B0.38190173
89RPS6KA30.38091287
90PRKG10.35869050
91RPS6KA40.35546221
92CAMK10.34665495
93PRKACB0.33200925
94RPS6KA50.32971316
95WNK40.31304595
96PRKCB0.30891254
97CAMK2D0.30614904
98CSNK1A10.30425085
99GSK3B0.29679359
100STK390.29633177

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050335.18982951
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97804583
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.93533540
4GABAergic synapse_Homo sapiens_hsa047272.82147201
5Glutamatergic synapse_Homo sapiens_hsa047242.66819824
6Morphine addiction_Homo sapiens_hsa050322.64412897
7Circadian entrainment_Homo sapiens_hsa047132.59610015
8Dopaminergic synapse_Homo sapiens_hsa047282.50690360
9Cocaine addiction_Homo sapiens_hsa050302.43222517
10Amphetamine addiction_Homo sapiens_hsa050312.38540527
11Synaptic vesicle cycle_Homo sapiens_hsa047212.27570109
12Insulin secretion_Homo sapiens_hsa049112.24333644
13Taste transduction_Homo sapiens_hsa047422.08223819
14Butanoate metabolism_Homo sapiens_hsa006501.91131751
15Phototransduction_Homo sapiens_hsa047441.80177777
16Cholinergic synapse_Homo sapiens_hsa047251.76713594
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74062454
18Long-term potentiation_Homo sapiens_hsa047201.71507035
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.64549853
20Long-term depression_Homo sapiens_hsa047301.57704620
21Axon guidance_Homo sapiens_hsa043601.50116216
22Type II diabetes mellitus_Homo sapiens_hsa049301.49933158
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49725122
24Serotonergic synapse_Homo sapiens_hsa047261.37164823
25Salivary secretion_Homo sapiens_hsa049701.37017115
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.28574809
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.26983964
28Renin secretion_Homo sapiens_hsa049241.23108732
29Gastric acid secretion_Homo sapiens_hsa049711.22973632
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21964252
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18654702
32Olfactory transduction_Homo sapiens_hsa047401.18314910
33cAMP signaling pathway_Homo sapiens_hsa040241.17559802
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10418247
35Calcium signaling pathway_Homo sapiens_hsa040201.10020040
36Gap junction_Homo sapiens_hsa045401.09515416
37Oxytocin signaling pathway_Homo sapiens_hsa049211.08784187
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07422884
39Collecting duct acid secretion_Homo sapiens_hsa049661.04506794
40Cardiac muscle contraction_Homo sapiens_hsa042600.98693682
41Circadian rhythm_Homo sapiens_hsa047100.98391919
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90400430
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88916310
44Estrogen signaling pathway_Homo sapiens_hsa049150.87816239
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85873036
46Protein export_Homo sapiens_hsa030600.85575627
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84984796
48ErbB signaling pathway_Homo sapiens_hsa040120.84328422
49Steroid biosynthesis_Homo sapiens_hsa001000.80810126
50Oocyte meiosis_Homo sapiens_hsa041140.78577118
51Alcoholism_Homo sapiens_hsa050340.74274778
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73880430
53Regulation of autophagy_Homo sapiens_hsa041400.71647344
54Ras signaling pathway_Homo sapiens_hsa040140.68213573
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66764746
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65482176
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65127245
58Hedgehog signaling pathway_Homo sapiens_hsa043400.63779716
59GnRH signaling pathway_Homo sapiens_hsa049120.60332768
60Melanogenesis_Homo sapiens_hsa049160.58169347
61Pancreatic secretion_Homo sapiens_hsa049720.58100869
62MAPK signaling pathway_Homo sapiens_hsa040100.57895688
63Ether lipid metabolism_Homo sapiens_hsa005650.56967269
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56965765
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55241901
66Ovarian steroidogenesis_Homo sapiens_hsa049130.53863134
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53642497
68Prolactin signaling pathway_Homo sapiens_hsa049170.53629454
69Hippo signaling pathway_Homo sapiens_hsa043900.52317803
70Bile secretion_Homo sapiens_hsa049760.51966513
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50170621
72Basal transcription factors_Homo sapiens_hsa030220.48147341
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47472704
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45806558
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45222217
76Fatty acid biosynthesis_Homo sapiens_hsa000610.44615962
77Thyroid hormone synthesis_Homo sapiens_hsa049180.44508441
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44427877
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43519825
80Vibrio cholerae infection_Homo sapiens_hsa051100.42832588
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41033694
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40638426
83Rap1 signaling pathway_Homo sapiens_hsa040150.39926224
84Wnt signaling pathway_Homo sapiens_hsa043100.39752412
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.39519632
86Tryptophan metabolism_Homo sapiens_hsa003800.39120772
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.37797651
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.37452448
89beta-Alanine metabolism_Homo sapiens_hsa004100.36959616
90mTOR signaling pathway_Homo sapiens_hsa041500.36578082
91AMPK signaling pathway_Homo sapiens_hsa041520.35582168
92Linoleic acid metabolism_Homo sapiens_hsa005910.34799489
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34378353
94Basal cell carcinoma_Homo sapiens_hsa052170.33966325
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32940843
96Dilated cardiomyopathy_Homo sapiens_hsa054140.32861773
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30830930
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30728692
99Glioma_Homo sapiens_hsa052140.30690274
100Alzheimers disease_Homo sapiens_hsa050100.30475667

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