KIAA2026

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)3.91836145
2histone H3-K4 trimethylation (GO:0080182)3.60298714
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.55315753
4establishment of protein localization to Golgi (GO:0072600)3.50494251
5positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.35192085
6retrograde transport, vesicle recycling within Golgi (GO:0000301)3.31633697
7protein targeting to Golgi (GO:0000042)3.25704677
8cerebral cortex radially oriented cell migration (GO:0021799)3.18520221
9interkinetic nuclear migration (GO:0022027)3.15356387
10neural tube formation (GO:0001841)2.96409103
11protein K11-linked deubiquitination (GO:0035871)2.95734788
12peptidyl-lysine trimethylation (GO:0018023)2.88402415
13central nervous system projection neuron axonogenesis (GO:0021952)2.86207144
14presynaptic membrane organization (GO:0097090)2.84609062
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77457342
16Golgi to endosome transport (GO:0006895)2.75403076
17nerve growth factor signaling pathway (GO:0038180)2.74628819
18cytoplasmic mRNA processing body assembly (GO:0033962)2.72409451
19nucleus localization (GO:0051647)2.70483562
20negative regulation of neurotransmitter transport (GO:0051589)2.68525226
21cerebellar Purkinje cell differentiation (GO:0021702)2.68515647
22negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65495979
23presynaptic membrane assembly (GO:0097105)2.63011690
24negative regulation of translation, ncRNA-mediated (GO:0040033)2.62477240
25regulation of translation, ncRNA-mediated (GO:0045974)2.62477240
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62477240
27regulation of pigment cell differentiation (GO:0050932)2.61806791
28central nervous system neuron axonogenesis (GO:0021955)2.54486258
29activated T cell proliferation (GO:0050798)2.54331394
30cyclic nucleotide catabolic process (GO:0009214)2.53752259
31pyrimidine nucleobase catabolic process (GO:0006208)2.53426046
32cAMP catabolic process (GO:0006198)2.51292783
33protein localization to Golgi apparatus (GO:0034067)2.49508917
34serotonin metabolic process (GO:0042428)2.48789616
35photoreceptor cell differentiation (GO:0046530)2.48686107
36eye photoreceptor cell differentiation (GO:0001754)2.48686107
37axon ensheathment in central nervous system (GO:0032291)2.45191124
38central nervous system myelination (GO:0022010)2.45191124
39ionotropic glutamate receptor signaling pathway (GO:0035235)2.44077094
40regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.42193699
41positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.42193699
42tachykinin receptor signaling pathway (GO:0007217)2.41980017
43glutamate receptor signaling pathway (GO:0007215)2.41054454
44regulation of sarcomere organization (GO:0060297)2.39273196
45regulation of protein glycosylation (GO:0060049)2.39091878
46establishment of nucleus localization (GO:0040023)2.35095460
47axonal fasciculation (GO:0007413)2.31969733
48regulation of B cell receptor signaling pathway (GO:0050855)2.29861107
49seminiferous tubule development (GO:0072520)2.29564745
50neuronal action potential (GO:0019228)2.27421973
51positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.26774630
52regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.26774630
53protein localization to cilium (GO:0061512)2.26416440
54monoubiquitinated protein deubiquitination (GO:0035520)2.24146762
55regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.23020860
56dopamine biosynthetic process (GO:0042416)2.22902475
57retina layer formation (GO:0010842)2.19942698
58startle response (GO:0001964)2.17720771
59positive regulation of cardiac muscle cell differentiation (GO:2000727)2.17481320
60histone H3-K4 methylation (GO:0051568)2.17461899
61neuron recognition (GO:0008038)2.17313449
62regulation of Rap GTPase activity (GO:0032317)2.15688880
63dentate gyrus development (GO:0021542)2.15549427
64phospholipid translocation (GO:0045332)2.14926548
65lipid translocation (GO:0034204)2.14926548
66vesicle transport along microtubule (GO:0047496)2.14909147
67peptidyl-lysine methylation (GO:0018022)2.14233117
68olfactory bulb development (GO:0021772)2.13694139
69nucleobase catabolic process (GO:0046113)2.13588075
70histone H3-K9 modification (GO:0061647)2.12978338
71negative regulation of neurotransmitter secretion (GO:0046929)2.12447371
72epithelial cell differentiation involved in kidney development (GO:0035850)2.11752555
73negative regulation of cAMP-mediated signaling (GO:0043951)2.11537579
74artery development (GO:0060840)2.11294604
75embryonic retina morphogenesis in camera-type eye (GO:0060059)2.09600757
76membrane depolarization during action potential (GO:0086010)2.09510391
77urinary tract smooth muscle contraction (GO:0014848)2.09380256
78embryonic hemopoiesis (GO:0035162)2.08004522
79negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.07567948
80postsynaptic membrane organization (GO:0001941)2.07239583
81protein polyglutamylation (GO:0018095)2.06537170
82detection of calcium ion (GO:0005513)2.06451497
83regulation of clathrin-mediated endocytosis (GO:2000369)2.06341344
84regulation of collateral sprouting (GO:0048670)2.05843202
85myofibril assembly (GO:0030239)2.05261289
86interleukin-6-mediated signaling pathway (GO:0070102)2.05180238
87histone H3-K9 demethylation (GO:0033169)2.05035898
88microtubule anchoring (GO:0034453)2.04960412
89phosphorelay signal transduction system (GO:0000160)2.04497323
90neuron maturation (GO:0042551)2.03854554
91mechanosensory behavior (GO:0007638)2.03770406
92regulation of dendritic spine development (GO:0060998)2.03710456
93epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.02529358
94early endosome to late endosome transport (GO:0045022)2.02427351
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.02007854
96substrate-independent telencephalic tangential migration (GO:0021826)2.00993551
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.00993551
98histone lysine methylation (GO:0034968)2.00950553
99negative regulation of T-helper cell differentiation (GO:0045623)2.00293481
100negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.00293481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05167565
2GBX2_23144817_ChIP-Seq_PC3_Human2.88216328
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.83480271
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39951547
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38621918
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18517289
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11901214
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.09654232
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02640117
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00010782
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94681888
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88887452
13TAF15_26573619_Chip-Seq_HEK293_Human1.84659233
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82982009
15SMAD4_21799915_ChIP-Seq_A2780_Human1.82915727
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80354787
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.76326169
18IGF1R_20145208_ChIP-Seq_DFB_Human1.71224912
19AR_21572438_ChIP-Seq_LNCaP_Human1.67542928
20P300_19829295_ChIP-Seq_ESCs_Human1.67075160
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63501982
22TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63501982
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63188234
24STAT3_23295773_ChIP-Seq_U87_Human1.62539214
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57890256
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55931098
27* TCF4_23295773_ChIP-Seq_U87_Human1.55876522
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55812658
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52346109
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.51093288
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50167280
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49175074
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48680380
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.48497018
35FUS_26573619_Chip-Seq_HEK293_Human1.46137269
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45682451
37BCAT_22108803_ChIP-Seq_LS180_Human1.45184699
38AR_25329375_ChIP-Seq_VCAP_Human1.44870615
39ER_23166858_ChIP-Seq_MCF-7_Human1.43657140
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43086926
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.42388522
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41634606
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41465458
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40563663
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.39984968
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39045953
47TP53_16413492_ChIP-PET_HCT116_Human1.38921240
48TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35715582
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35541036
50DROSHA_22980978_ChIP-Seq_HELA_Human1.34851319
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34656407
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32138420
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31933536
54REST_21632747_ChIP-Seq_MESCs_Mouse1.31277870
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.29790135
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29611147
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.29273014
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28621014
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28034258
60VDR_22108803_ChIP-Seq_LS180_Human1.25212172
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.24324151
62AHR_22903824_ChIP-Seq_MCF-7_Human1.23775018
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23223116
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23064175
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21086871
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20929576
67CBP_20019798_ChIP-Seq_JUKART_Human1.20929576
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.20708354
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20540515
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.20393782
71P53_22387025_ChIP-Seq_ESCs_Mouse1.20108356
72RUNX2_22187159_ChIP-Seq_PCA_Human1.19966153
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19949593
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.19772451
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19475581
76EWS_26573619_Chip-Seq_HEK293_Human1.18745303
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18667506
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18401932
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.18300002
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.16341753
81ZNF274_21170338_ChIP-Seq_K562_Hela1.15069561
82CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13845700
83KDM2B_26808549_Chip-Seq_REH_Human1.13421129
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13181351
85RNF2_27304074_Chip-Seq_NSC_Mouse1.11758598
86RUNX_20019798_ChIP-Seq_JUKART_Human1.11754328
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.10588873
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10369809
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.08276765
90RXR_22108803_ChIP-Seq_LS180_Human1.07986219
91TCF4_22108803_ChIP-Seq_LS180_Human1.04663710
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04605304
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03270311
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02683085
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02272064
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.01586934
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01297992
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01297992
99WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01267177
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99776540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.23428502
2MP0003787_abnormal_imprinting3.75165049
3MP0008057_abnormal_DNA_replication2.98753952
4MP0003880_abnormal_central_pattern2.71733517
5MP0008877_abnormal_DNA_methylation2.55205724
6MP0003646_muscle_fatigue2.44042621
7MP0003635_abnormal_synaptic_transmissio2.17500177
8MP0004885_abnormal_endolymph2.14222053
9MP0004270_analgesia2.10201907
10MP0009745_abnormal_behavioral_response2.09509023
11MP0001486_abnormal_startle_reflex2.08616456
12MP0004130_abnormal_muscle_cell1.95994850
13MP0004145_abnormal_muscle_electrophysio1.94197062
14MP0005174_abnormal_tail_pigmentation1.92865958
15MP0000778_abnormal_nervous_system1.92673253
16MP0004859_abnormal_synaptic_plasticity1.86531756
17MP0003121_genomic_imprinting1.82804439
18MP0005423_abnormal_somatic_nervous1.81768538
19MP0002064_seizures1.80376351
20MP0002063_abnormal_learning/memory/cond1.80261340
21MP0002272_abnormal_nervous_system1.79948986
22MP0005409_darkened_coat_color1.75327435
23MP0003122_maternal_imprinting1.72239542
24MP0009046_muscle_twitch1.69020116
25MP0005645_abnormal_hypothalamus_physiol1.64966380
26MP0001984_abnormal_olfaction1.64041301
27MP0005551_abnormal_eye_electrophysiolog1.63911115
28MP0004043_abnormal_pH_regulation1.60685285
29MP0001501_abnormal_sleep_pattern1.58916819
30MP0002572_abnormal_emotion/affect_behav1.56902112
31MP0003045_fibrosis1.50422610
32MP0004924_abnormal_behavior1.43784237
33MP0005386_behavior/neurological_phenoty1.43784237
34MP0003195_calcinosis1.43723431
35MP0003890_abnormal_embryonic-extraembry1.43367724
36MP0005646_abnormal_pituitary_gland1.39963775
37MP0002067_abnormal_sensory_capabilities1.38667289
38MP0000427_abnormal_hair_cycle1.38020024
39MP0003633_abnormal_nervous_system1.36734385
40MP0000631_abnormal_neuroendocrine_gland1.34273532
41MP0004142_abnormal_muscle_tone1.33813433
42MP0004484_altered_response_of1.28210404
43MP0002735_abnormal_chemical_nociception1.27329507
44MP0000015_abnormal_ear_pigmentation1.25090707
45MP0002734_abnormal_mechanical_nocicepti1.24512034
46MP0003690_abnormal_glial_cell1.24415089
47MP0002557_abnormal_social/conspecific_i1.21650710
48MP0001970_abnormal_pain_threshold1.20858649
49MP0003011_delayed_dark_adaptation1.19963741
50MP0005310_abnormal_salivary_gland1.18749249
51MP0001188_hyperpigmentation1.18308631
52MP0002837_dystrophic_cardiac_calcinosis1.18084884
53MP0004036_abnormal_muscle_relaxation1.17139523
54MP0001968_abnormal_touch/_nociception1.16479705
55MP0003631_nervous_system_phenotype1.13977255
56MP0009780_abnormal_chondrocyte_physiolo1.13783034
57MP0002909_abnormal_adrenal_gland1.12494169
58MP0002733_abnormal_thermal_nociception1.10078794
59MP0002184_abnormal_innervation1.08662589
60MP0008569_lethality_at_weaning1.06561409
61MP0001440_abnormal_grooming_behavior1.05960934
62MP0001986_abnormal_taste_sensitivity1.04392399
63MP0003632_abnormal_nervous_system1.04369275
64MP0002882_abnormal_neuron_morphology1.02618083
65MP0005253_abnormal_eye_physiology0.96636912
66MP0004742_abnormal_vestibular_system0.95998257
67MP0001502_abnormal_circadian_rhythm0.94052022
68MP0003879_abnormal_hair_cell0.93462672
69MP0000955_abnormal_spinal_cord0.92605331
70MP0010386_abnormal_urinary_bladder0.92466509
71MP0002168_other_aberrant_phenotype0.91632777
72MP0004215_abnormal_myocardial_fiber0.91238570
73MP0008995_early_reproductive_senescence0.90428742
74MP0002229_neurodegeneration0.89921163
75MP0004811_abnormal_neuron_physiology0.86709879
76MP0002152_abnormal_brain_morphology0.85887403
77MP0001485_abnormal_pinna_reflex0.85709647
78MP0002066_abnormal_motor_capabilities/c0.84736766
79MP0002822_catalepsy0.84624424
80MP0002095_abnormal_skin_pigmentation0.84020170
81MP0003183_abnormal_peptide_metabolism0.82317045
82MP0006276_abnormal_autonomic_nervous0.82142818
83MP0002332_abnormal_exercise_endurance0.79442378
84MP0000230_abnormal_systemic_arterial0.78942082
85MP0002009_preneoplasia0.78676487
86MP0006292_abnormal_olfactory_placode0.78239582
87MP0002876_abnormal_thyroid_physiology0.77673473
88MP0004883_abnormal_blood_vessel0.76838851
89MP0005379_endocrine/exocrine_gland_phen0.75944480
90MP0000013_abnormal_adipose_tissue0.75135032
91MP0003724_increased_susceptibility_to0.74167479
92MP0005620_abnormal_muscle_contractility0.73258672
93MP0004084_abnormal_cardiac_muscle0.72026029
94MP0003943_abnormal_hepatobiliary_system0.71212515
95MP0003828_pulmonary_edema0.70155111
96MP0005448_abnormal_energy_balance0.69949210
97MP0004085_abnormal_heartbeat0.68960248
98MP0001879_abnormal_lymphatic_vessel0.66713311
99MP0002752_abnormal_somatic_nervous0.66049006
100MP0005535_abnormal_body_temperature0.65922898

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.96761263
2Volvulus (HP:0002580)3.66843184
3Progressive cerebellar ataxia (HP:0002073)3.44385619
4Papillary thyroid carcinoma (HP:0002895)3.24450290
5Chronic hepatic failure (HP:0100626)3.20293678
6Febrile seizures (HP:0002373)3.20264560
7Drooling (HP:0002307)3.00931247
8Truncal obesity (HP:0001956)2.99055038
9Widely spaced teeth (HP:0000687)2.87155521
10Excessive salivation (HP:0003781)2.86374505
11Gaze-evoked nystagmus (HP:0000640)2.84286974
12Broad-based gait (HP:0002136)2.83996282
13Protruding tongue (HP:0010808)2.82564190
14Genetic anticipation (HP:0003743)2.78162473
15Focal seizures (HP:0007359)2.77727602
16Focal motor seizures (HP:0011153)2.76102065
17Absent speech (HP:0001344)2.71236631
18Atonic seizures (HP:0010819)2.67489912
19Oligodactyly (hands) (HP:0001180)2.53630834
20Abnormality of the renal medulla (HP:0100957)2.52274916
21Nephronophthisis (HP:0000090)2.50384615
22Fair hair (HP:0002286)2.42012927
23Abnormality of the ischium (HP:0003174)2.38505929
24Abnormality of the renal cortex (HP:0011035)2.35986762
25Epileptic encephalopathy (HP:0200134)2.33035278
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30466959
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.30466959
28Papilledema (HP:0001085)2.28808122
29Dialeptic seizures (HP:0011146)2.28585078
30True hermaphroditism (HP:0010459)2.23796584
31Generalized hypopigmentation of hair (HP:0011358)2.21802437
32Difficulty running (HP:0009046)2.20370864
33Gait imbalance (HP:0002141)2.19378835
34Medial flaring of the eyebrow (HP:0010747)2.16943453
35Hypoplastic ischia (HP:0003175)2.15923008
36Pancreatic fibrosis (HP:0100732)2.15489050
37Metaphyseal dysplasia (HP:0100255)2.13608557
38Poor coordination (HP:0002370)2.09429493
39Postural instability (HP:0002172)2.08032838
40Tented upper lip vermilion (HP:0010804)2.07698914
41Hip dysplasia (HP:0001385)2.07396980
42Absence seizures (HP:0002121)2.06223406
43Macroorchidism (HP:0000053)2.05988712
44Amyotrophic lateral sclerosis (HP:0007354)2.04446283
45Tapered finger (HP:0001182)2.03411803
46Pancreatic cysts (HP:0001737)2.02150348
47Blue irides (HP:0000635)2.01743533
48Abnormal hair whorl (HP:0010721)2.01274319
49Action tremor (HP:0002345)2.00412960
50Hepatoblastoma (HP:0002884)1.99187825
51Abnormality of midbrain morphology (HP:0002418)1.98506924
52Molar tooth sign on MRI (HP:0002419)1.98506924
53Stomach cancer (HP:0012126)1.97328941
54Abnormality of the corticospinal tract (HP:0002492)1.96790512
55Hyperkalemia (HP:0002153)1.96316670
56Tubulointerstitial nephritis (HP:0001970)1.96157855
57Agitation (HP:0000713)1.93334345
58Calf muscle hypertrophy (HP:0008981)1.91264315
59Overgrowth (HP:0001548)1.90854746
60Nephrogenic diabetes insipidus (HP:0009806)1.90836170
61Thyroiditis (HP:0100646)1.89889066
62Intestinal atresia (HP:0011100)1.85653688
63Polydipsia (HP:0001959)1.85481069
64Abnormal drinking behavior (HP:0030082)1.85481069
65Abnormality of incisor morphology (HP:0011063)1.85459039
66Hypoplastic iliac wings (HP:0002866)1.84022269
67Hemiplegia (HP:0002301)1.83065648
68Exotropia (HP:0000577)1.80983667
69Congenital primary aphakia (HP:0007707)1.79715567
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79185883
71Hypochromic microcytic anemia (HP:0004840)1.78760177
72Thyroid carcinoma (HP:0002890)1.78734803
73Prolonged QT interval (HP:0001657)1.77730599
74Poor eye contact (HP:0000817)1.77626712
75Cystic hygroma (HP:0000476)1.76455025
76Aqueductal stenosis (HP:0002410)1.75952859
77Testicular neoplasm (HP:0010788)1.75364567
78Abnormality of salivation (HP:0100755)1.74585749
79Muscle hypertrophy of the lower extremities (HP:0008968)1.74021512
80Syncope (HP:0001279)1.73373319
81Menstrual irregularities (HP:0000858)1.73179147
82Urinary bladder sphincter dysfunction (HP:0002839)1.72897787
83Genital tract atresia (HP:0001827)1.71740343
84Abnormality of secondary sexual hair (HP:0009888)1.71147432
85Abnormality of the axillary hair (HP:0100134)1.71147432
86Abnormality of the left ventricular outflow tract (HP:0011103)1.69709504
87Subaortic stenosis (HP:0001682)1.69709504
88Abnormality of the nasal septum (HP:0000419)1.69626975
89Narrow palate (HP:0000189)1.67661175
90Hemiparesis (HP:0001269)1.66888658
91Increased circulating renin level (HP:0000848)1.66831702
92Vertebral arch anomaly (HP:0008438)1.66536846
93Spontaneous hematomas (HP:0007420)1.64033003
94Abnormality of binocular vision (HP:0011514)1.63186163
95Diplopia (HP:0000651)1.63186163
96Neoplasm of the tracheobronchial system (HP:0100552)1.60716272
97Thick eyebrow (HP:0000574)1.59719850
98Ventricular fibrillation (HP:0001663)1.59636100
99Hematochezia (HP:0002573)1.59623958
100Short 4th metacarpal (HP:0010044)1.59492025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.85229031
2CASK3.04459127
3MARK12.55264230
4SGK22.22380211
5NTRK32.03153734
6TAOK31.93809472
7NLK1.84347223
8MAPK131.82578131
9LATS11.81043030
10PNCK1.80442433
11CAMKK21.75872536
12WNK11.69460181
13CAMK1G1.64354218
14TNIK1.63928069
15WNK31.62418215
16AKT31.56299313
17PAK31.54213849
18MAP3K41.54031764
19NUAK11.50099580
20SGK2231.49592818
21SGK4941.49592818
22IRAK21.44470901
23OBSCN1.41999403
24INSRR1.39489806
25SGK31.33265510
26EPHA41.31449410
27ACVR1B1.27054759
28PIK3CG1.25256098
29PINK11.19773413
30NTRK21.17908977
31STK111.16299150
32IRAK11.15429886
33MARK21.14882676
34TEC1.11467815
35CAMK1D1.07317681
36BMPR1B1.07167373
37SGK11.04444263
38CAMK10.96335854
39CAMK40.95992812
40SIK20.95395024
41YES10.95174667
42FGFR30.95168103
43JAK10.94611797
44MAP3K70.94265587
45DMPK0.92922360
46MAP4K20.90740856
47DYRK1A0.87302092
48BRD40.87129466
49STK390.83996127
50MAP2K40.82125829
51TXK0.81535747
52CDK30.80765299
53FES0.80008651
54OXSR10.77938915
55MAPK70.77782614
56MARK30.73638553
57FGFR20.72721275
58MAPK120.72434570
59DAPK20.71022665
60IKBKE0.70737292
61MINK10.70342352
62PRKCZ0.70211054
63TNK20.69379930
64PRKCH0.68612469
65EPHA30.67825415
66STK380.67576816
67PKN10.67213495
68RIPK40.66411046
69MAP3K20.66037802
70SYK0.65862453
71CAMKK10.64286152
72ADRBK20.61894734
73PTK2B0.61370139
74PHKG10.61098693
75PHKG20.61098693
76PLK20.60765888
77PIK3CA0.60653839
78PRKG10.59468549
79CDK50.59082394
80PRKCG0.58937266
81STK30.56915452
82PRKCE0.56605637
83UHMK10.56182200
84STK38L0.56044011
85ITK0.54597210
86PDGFRB0.54596146
87PRKCQ0.53715781
88GRK50.52737605
89PRKAA20.52211000
90TAOK10.50471316
91KSR10.49982216
92CHUK0.49250302
93MAPK100.49029709
94MAP3K100.47911818
95BTK0.47849452
96ERBB30.45417776
97RPS6KA30.44511988
98CAMK2A0.44307626
99ADRBK10.44132356
100ERBB20.44026322

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043202.28139314
2Nicotine addiction_Homo sapiens_hsa050332.06139887
3Long-term potentiation_Homo sapiens_hsa047201.86304746
4Circadian entrainment_Homo sapiens_hsa047131.85498847
5Renin secretion_Homo sapiens_hsa049241.77429938
6Glutamatergic synapse_Homo sapiens_hsa047241.70363988
7Circadian rhythm_Homo sapiens_hsa047101.63027708
8Morphine addiction_Homo sapiens_hsa050321.62732711
9Insulin secretion_Homo sapiens_hsa049111.61934301
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61317566
11Amphetamine addiction_Homo sapiens_hsa050311.55879123
12Long-term depression_Homo sapiens_hsa047301.52908055
13Dopaminergic synapse_Homo sapiens_hsa047281.47417392
14Cholinergic synapse_Homo sapiens_hsa047251.43611377
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43437725
16Oxytocin signaling pathway_Homo sapiens_hsa049211.42056845
17Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41100457
18Salivary secretion_Homo sapiens_hsa049701.31110301
19Calcium signaling pathway_Homo sapiens_hsa040201.29153472
20GABAergic synapse_Homo sapiens_hsa047271.27781951
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24699408
22cAMP signaling pathway_Homo sapiens_hsa040241.24657235
23Regulation of autophagy_Homo sapiens_hsa041401.22702348
24Gastric acid secretion_Homo sapiens_hsa049711.20509630
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20248525
26Taste transduction_Homo sapiens_hsa047421.18827721
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18770602
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.18543932
29Serotonergic synapse_Homo sapiens_hsa047261.15703608
30FoxO signaling pathway_Homo sapiens_hsa040681.14201393
31Inositol phosphate metabolism_Homo sapiens_hsa005621.11952185
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11685963
33Platelet activation_Homo sapiens_hsa046111.10922178
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10587678
35Cocaine addiction_Homo sapiens_hsa050301.09508154
36Phototransduction_Homo sapiens_hsa047441.08574153
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08332726
38Type II diabetes mellitus_Homo sapiens_hsa049301.05214697
39T cell receptor signaling pathway_Homo sapiens_hsa046601.02775969
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.02735186
41Prolactin signaling pathway_Homo sapiens_hsa049171.01871576
42GnRH signaling pathway_Homo sapiens_hsa049121.01704134
43B cell receptor signaling pathway_Homo sapiens_hsa046621.01231699
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00801010
45Pancreatic secretion_Homo sapiens_hsa049721.00077116
46Olfactory transduction_Homo sapiens_hsa047400.96795232
47MAPK signaling pathway_Homo sapiens_hsa040100.95575730
48Estrogen signaling pathway_Homo sapiens_hsa049150.94998652
49Choline metabolism in cancer_Homo sapiens_hsa052310.93361771
50mTOR signaling pathway_Homo sapiens_hsa041500.92722282
51Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91634943
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.90767378
53Axon guidance_Homo sapiens_hsa043600.89102944
54Ras signaling pathway_Homo sapiens_hsa040140.87732970
55Ether lipid metabolism_Homo sapiens_hsa005650.86774046
56Endometrial cancer_Homo sapiens_hsa052130.79494360
57Renal cell carcinoma_Homo sapiens_hsa052110.78382140
58Gap junction_Homo sapiens_hsa045400.77315369
59ErbB signaling pathway_Homo sapiens_hsa040120.77176891
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.76727147
61Linoleic acid metabolism_Homo sapiens_hsa005910.75801312
62Insulin resistance_Homo sapiens_hsa049310.75444359
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75326485
64Rap1 signaling pathway_Homo sapiens_hsa040150.74601097
65Chemokine signaling pathway_Homo sapiens_hsa040620.74266038
66Dilated cardiomyopathy_Homo sapiens_hsa054140.73742355
67Glioma_Homo sapiens_hsa052140.73241904
68ABC transporters_Homo sapiens_hsa020100.72781721
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71832566
70Ovarian steroidogenesis_Homo sapiens_hsa049130.70065189
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69956844
72Glucagon signaling pathway_Homo sapiens_hsa049220.69062283
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68856448
74Lysine degradation_Homo sapiens_hsa003100.68291123
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68032500
76Non-small cell lung cancer_Homo sapiens_hsa052230.67890089
77VEGF signaling pathway_Homo sapiens_hsa043700.67350275
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66532218
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.65716261
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.65050966
81Colorectal cancer_Homo sapiens_hsa052100.63056448
82Osteoclast differentiation_Homo sapiens_hsa043800.62893568
83Melanogenesis_Homo sapiens_hsa049160.62511967
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61146781
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59631925
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.59247810
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58504234
88Wnt signaling pathway_Homo sapiens_hsa043100.54425599
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54362385
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53646580
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52377306
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50203925
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48672358
94Thyroid hormone synthesis_Homo sapiens_hsa049180.47596297
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47439868
96Prostate cancer_Homo sapiens_hsa052150.46025324
97Nitrogen metabolism_Homo sapiens_hsa009100.45750227
98Pancreatic cancer_Homo sapiens_hsa052120.45549962
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44551940
100Synaptic vesicle cycle_Homo sapiens_hsa047210.44231153

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