KIF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.12972210
2DNA unwinding involved in DNA replication (GO:0006268)5.59064823
3mitotic chromosome condensation (GO:0007076)5.42168676
4protein localization to chromosome, centromeric region (GO:0071459)5.35305457
5sister chromatid segregation (GO:0000819)5.32882763
6mitotic sister chromatid segregation (GO:0000070)5.22705582
7kinetochore organization (GO:0051383)5.16491142
8DNA ligation (GO:0006266)5.11376339
9nuclear pore organization (GO:0006999)5.07215618
10nuclear pore complex assembly (GO:0051292)5.07078760
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.03086284
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.76352850
13mitotic sister chromatid cohesion (GO:0007064)4.76309669
14mitotic metaphase plate congression (GO:0007080)4.71041353
15attachment of spindle microtubules to kinetochore (GO:0008608)4.56886760
16regulation of spindle organization (GO:0090224)4.46976272
17DNA strand elongation involved in DNA replication (GO:0006271)4.44331066
18DNA replication-dependent nucleosome assembly (GO:0006335)4.40629431
19DNA replication-dependent nucleosome organization (GO:0034723)4.40629431
20chromatin remodeling at centromere (GO:0031055)4.39886183
21CENP-A containing nucleosome assembly (GO:0034080)4.39333371
22mitotic nuclear envelope disassembly (GO:0007077)4.36866337
23metaphase plate congression (GO:0051310)4.36851350
24DNA replication initiation (GO:0006270)4.27109634
25DNA strand elongation (GO:0022616)4.21439713
26mitotic recombination (GO:0006312)4.19406056
27telomere maintenance via semi-conservative replication (GO:0032201)4.15775243
28kinetochore assembly (GO:0051382)4.15314009
29DNA replication-independent nucleosome organization (GO:0034724)4.13326797
30DNA replication-independent nucleosome assembly (GO:0006336)4.13326797
31meiotic chromosome segregation (GO:0045132)4.09773072
32establishment of chromosome localization (GO:0051303)4.08814082
33nuclear envelope disassembly (GO:0051081)4.08217865
34membrane disassembly (GO:0030397)4.08217865
35positive regulation of chromosome segregation (GO:0051984)4.03829788
36DNA topological change (GO:0006265)3.98854369
37establishment of integrated proviral latency (GO:0075713)3.98743606
38regulation of mitotic spindle organization (GO:0060236)3.96724384
39DNA geometric change (GO:0032392)3.93085825
40DNA duplex unwinding (GO:0032508)3.93011242
41telomere maintenance via recombination (GO:0000722)3.91933854
42regulation of histone H3-K9 methylation (GO:0051570)3.91146571
43protein localization to chromosome (GO:0034502)3.89578483
44pore complex assembly (GO:0046931)3.88621975
45DNA replication checkpoint (GO:0000076)3.88103841
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.85435695
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.85435695
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.85435695
49regulation of sister chromatid cohesion (GO:0007063)3.82966617
50regulation of chromosome segregation (GO:0051983)3.81643902
51histone exchange (GO:0043486)3.79846167
52spindle checkpoint (GO:0031577)3.77731117
53chromosome condensation (GO:0030261)3.76836226
54chromatin assembly or disassembly (GO:0006333)3.73530382
55regulation of DNA endoreduplication (GO:0032875)3.69497174
56* chromosome segregation (GO:0007059)3.61490567
57spindle assembly checkpoint (GO:0071173)3.58460733
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.57381141
59double-strand break repair via nonhomologous end joining (GO:0006303)3.55252155
60non-recombinational repair (GO:0000726)3.55252155
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53230764
62DNA conformation change (GO:0071103)3.49611155
63regulation of centrosome cycle (GO:0046605)3.49330967
64negative regulation of chromosome segregation (GO:0051985)3.49292388
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.48866302
66translesion synthesis (GO:0019985)3.46310482
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.44717323
68negative regulation of sister chromatid segregation (GO:0033046)3.44717323
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.44717323
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.44717323
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.42569346
72folic acid-containing compound biosynthetic process (GO:0009396)3.41172362
73mitotic spindle assembly checkpoint (GO:0007094)3.40419698
74mitotic spindle checkpoint (GO:0071174)3.39939953
75negative regulation of histone methylation (GO:0031061)3.39781054
76IMP biosynthetic process (GO:0006188)3.39548472
77mitotic G2/M transition checkpoint (GO:0044818)3.39283425
78telomere maintenance via telomere lengthening (GO:0010833)3.38750100
79regulation of mitotic sister chromatid separation (GO:0010965)3.38415319
80regulation of mitotic sister chromatid segregation (GO:0033047)3.38415319
81regulation of sister chromatid segregation (GO:0033045)3.38415319
82ATP-dependent chromatin remodeling (GO:0043044)3.37729439
83DNA packaging (GO:0006323)3.36510696
84negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34070585
85negative regulation of mitosis (GO:0045839)3.33629711
86dosage compensation (GO:0007549)3.32081888
87mitotic cytokinesis (GO:0000281)3.31921068
88regulation of centriole replication (GO:0046599)3.30938763
89chromatin assembly (GO:0031497)3.30228126
90V(D)J recombination (GO:0033151)3.24201264
91establishment of mitotic spindle localization (GO:0040001)3.23308600
92microtubule depolymerization (GO:0007019)3.21128340
93nuclear envelope organization (GO:0006998)3.17988578
94postreplication repair (GO:0006301)3.17947065
95chromosome organization (GO:0051276)3.15462992
96protein K6-linked ubiquitination (GO:0085020)3.14811001
97histone-serine phosphorylation (GO:0035404)3.14532777
98protein complex localization (GO:0031503)3.10398802
99* mitotic spindle organization (GO:0007052)3.09911227
100* spindle organization (GO:0007051)3.08058180
101nucleobase biosynthetic process (GO:0046112)3.06030783
102positive regulation of cell cycle checkpoint (GO:1901978)3.05380944
103regulation of RNA export from nucleus (GO:0046831)3.04290979
104heterochromatin organization (GO:0070828)3.01798671
105telomere maintenance (GO:0000723)3.01604773
106regulation of spindle checkpoint (GO:0090231)3.00859863
107negative regulation of cell division (GO:0051782)3.00547841
108IMP metabolic process (GO:0046040)2.99781701
109telomere organization (GO:0032200)2.99126217
110* mitotic nuclear division (GO:0007067)2.98719954
111mitotic cell cycle (GO:0000278)2.98624915
112negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.98572181
113mitotic DNA integrity checkpoint (GO:0044774)2.97807318
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96478134
115pre-miRNA processing (GO:0031054)2.95145921
116regulation of centrosome duplication (GO:0010824)2.94450012
117DNA synthesis involved in DNA repair (GO:0000731)2.90392070
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.89471250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.05514879
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.93070294
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11521316
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41104956
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.09587879
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.94681316
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84173488
8AR_21909140_ChIP-Seq_LNCAP_Human2.71017829
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.50421214
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49494728
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44530193
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35818097
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34974480
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14819991
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10799543
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05146818
17E2F7_22180533_ChIP-Seq_HELA_Human11.3406743
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97013092
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.95051034
20MYC_22102868_ChIP-Seq_BL_Human1.92075540
21* XRN2_22483619_ChIP-Seq_HELA_Human1.90050097
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85281601
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80473121
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77217016
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71805143
26VDR_23849224_ChIP-Seq_CD4+_Human1.69297325
27* ETS1_20019798_ChIP-Seq_JURKAT_Human1.62681127
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62482389
29CIITA_25753668_ChIP-Seq_RAJI_Human1.59899371
30FOXP3_21729870_ChIP-Seq_TREG_Human1.59172550
31ELK1_19687146_ChIP-ChIP_HELA_Human1.59096837
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.57718832
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.52882140
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50802750
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.50753341
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50731811
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50402958
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48067401
39TTF2_22483619_ChIP-Seq_HELA_Human1.45787500
40* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43523180
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41480137
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40606762
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39973918
44* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38893134
45DCP1A_22483619_ChIP-Seq_HELA_Human1.38141919
46* KDM5A_27292631_Chip-Seq_BREAST_Human1.36293866
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34350412
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31548057
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30903997
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30024633
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29838438
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28773152
53JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28578677
54* GABP_19822575_ChIP-Seq_HepG2_Human1.23119316
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21558122
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21046690
57VDR_21846776_ChIP-Seq_THP-1_Human1.18314472
58* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18277682
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16286792
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15899599
61* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15361105
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13485142
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10219297
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06843906
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04007351
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03613109
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03584987
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02211050
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01749087
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00657878
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00551867
72TFEB_21752829_ChIP-Seq_HELA_Human1.00022326
73SOX17_20123909_ChIP-Seq_XEN_Mouse0.98913663
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98836716
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98701590
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97824986
77NANOG_21062744_ChIP-ChIP_HESCs_Human0.95899874
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95621620
79* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94123708
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94067419
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92384080
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91561851
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89066431
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86774166
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83813200
86GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81914165
87MYC_18940864_ChIP-ChIP_HL60_Human0.81645458
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81280326
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81102693
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.80571276
91SPI1_23547873_ChIP-Seq_NB4_Human0.80118255
92* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78492035
93TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76869625
94* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76539420
95MYB_26560356_Chip-Seq_TH2_Human0.75866462
96MYB_26560356_Chip-Seq_TH1_Human0.75021450
97UTX_26944678_Chip-Seq_JUKART_Human0.74858237
98* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74335507
99E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.74247065
100* CHD1_26751641_Chip-Seq_LNCaP_Human0.74145654
101EWS_26573619_Chip-Seq_HEK293_Human0.73677004
102PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72731033
103YY1_21170310_ChIP-Seq_MESCs_Mouse0.71892944
104* SOX2_16153702_ChIP-ChIP_HESCs_Human0.70574450
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.70513754
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69397839
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69146139
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.68834034
109* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.68160481
110HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.66261754
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.64980504
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.64289186
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.63743732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.94083762
2MP0003111_abnormal_nucleus_morphology4.62959257
3* MP0003693_abnormal_embryo_hatching4.23430521
4MP0008057_abnormal_DNA_replication4.05471517
5MP0003077_abnormal_cell_cycle4.03160875
6MP0004957_abnormal_blastocyst_morpholog3.93915604
7MP0010307_abnormal_tumor_latency2.73706185
8MP0008058_abnormal_DNA_repair2.71401408
9MP0008007_abnormal_cellular_replicative2.61516662
10MP0010352_gastrointestinal_tract_polyps2.53352659
11MP0008932_abnormal_embryonic_tissue2.41985196
12MP0003123_paternal_imprinting2.34351752
13MP0000350_abnormal_cell_proliferation2.33544757
14MP0002396_abnormal_hematopoietic_system2.31980995
15* MP0001730_embryonic_growth_arrest2.28005088
16MP0009697_abnormal_copulation2.19618406
17MP0005076_abnormal_cell_differentiation2.17395447
18MP0008877_abnormal_DNA_methylation2.03545803
19* MP0001672_abnormal_embryogenesis/_devel1.84325054
20* MP0005380_embryogenesis_phenotype1.84325054
21MP0003121_genomic_imprinting1.82101149
22MP0004808_abnormal_hematopoietic_stem1.80907849
23* MP0001697_abnormal_embryo_size1.77100055
24MP0004197_abnormal_fetal_growth/weight/1.71707519
25MP0003984_embryonic_growth_retardation1.70119123
26MP0002088_abnormal_embryonic_growth/wei1.67146584
27MP0002085_abnormal_embryonic_tissue1.66154015
28MP0002084_abnormal_developmental_patter1.64778542
29MP0003705_abnormal_hypodermis_morpholog1.64770078
30MP0002086_abnormal_extraembryonic_tissu1.62113909
31* MP0002080_prenatal_lethality1.59485483
32MP0000490_abnormal_crypts_of1.58267048
33MP0003786_premature_aging1.54466354
34MP0003567_abnormal_fetal_cardiomyocyte1.52446347
35MP0001346_abnormal_lacrimal_gland1.50133808
36MP0002019_abnormal_tumor_incidence1.40143287
37MP0000313_abnormal_cell_death1.39280461
38MP0006054_spinal_hemorrhage1.36303611
39MP0003890_abnormal_embryonic-extraembry1.34829809
40MP0006292_abnormal_olfactory_placode1.28995050
41MP0000537_abnormal_urethra_morphology1.28504775
42MP0000703_abnormal_thymus_morphology1.27038572
43MP0009278_abnormal_bone_marrow1.19506440
44MP0010030_abnormal_orbit_morphology1.19340953
45MP0001293_anophthalmia1.17745591
46MP0009053_abnormal_anal_canal1.17559694
47MP0005397_hematopoietic_system_phenotyp1.11755233
48MP0001545_abnormal_hematopoietic_system1.11755233
49MP0003937_abnormal_limbs/digits/tail_de1.09355509
50MP0002398_abnormal_bone_marrow1.09246040
51MP0000569_abnormal_digit_pigmentation1.07861455
52MP0002210_abnormal_sex_determination1.06273891
53MP0009703_decreased_birth_body1.06273235
54MP0009672_abnormal_birth_weight1.04799311
55MP0002722_abnormal_immune_system1.00015496
56MP0003566_abnormal_cell_adhesion0.98538145
57MP0003763_abnormal_thymus_physiology0.94773812
58MP0005623_abnormal_meninges_morphology0.94540817
59MP0001145_abnormal_male_reproductive0.94256196
60MP0003315_abnormal_perineum_morphology0.92306832
61MP0000733_abnormal_muscle_development0.91405456
62MP0004185_abnormal_adipocyte_glucose0.90197181
63MP0000689_abnormal_spleen_morphology0.89575620
64MP0003861_abnormal_nervous_system0.88958943
65MP0000428_abnormal_craniofacial_morphol0.88344581
66MP0002233_abnormal_nose_morphology0.87697750
67MP0000358_abnormal_cell_content/0.87576129
68MP0000566_synostosis0.86639341
69MP0004233_abnormal_muscle_weight0.86189672
70MP0010234_abnormal_vibrissa_follicle0.86147379
71MP0002111_abnormal_tail_morphology0.85790689
72MP0001915_intracranial_hemorrhage0.84875297
73MP0001929_abnormal_gametogenesis0.84114973
74MP0003787_abnormal_imprinting0.83879777
75MP0002092_abnormal_eye_morphology0.83762474
76MP0005023_abnormal_wound_healing0.83490773
77MP0005621_abnormal_cell_physiology0.82488451
78MP0003385_abnormal_body_wall0.80343992
79MP0000653_abnormal_sex_gland0.79022467
80MP0009333_abnormal_splenocyte_physiolog0.78872738
81MP0000383_abnormal_hair_follicle0.78814543
82MP0005384_cellular_phenotype0.78588568
83MP0001299_abnormal_eye_distance/0.78270889
84MP0005501_abnormal_skin_physiology0.78002336
85MP0003943_abnormal_hepatobiliary_system0.77928895
86MP0003136_yellow_coat_color0.76973233
87MP0001849_ear_inflammation0.76832205
88MP0003718_maternal_effect0.76519699
89MP0000432_abnormal_head_morphology0.76088745
90MP0006035_abnormal_mitochondrial_morpho0.75998587
91MP0003935_abnormal_craniofacial_develop0.75576012
92MP0003950_abnormal_plasma_membrane0.75448828
93MP0002429_abnormal_blood_cell0.75350258
94MP0002697_abnormal_eye_size0.74958904
95MP0003119_abnormal_digestive_system0.73764580
96MP0002925_abnormal_cardiovascular_devel0.73719581
97MP0001661_extended_life_span0.72310599
98MP0002166_altered_tumor_susceptibility0.72243227
99MP0003221_abnormal_cardiomyocyte_apopto0.71869767
100MP0001286_abnormal_eye_development0.71007112
101MP0002095_abnormal_skin_pigmentation0.70245653
102MP0010678_abnormal_skin_adnexa0.70186404
103MP0003115_abnormal_respiratory_system0.69448071
104MP0002006_tumorigenesis0.69428920
105MP0002877_abnormal_melanocyte_morpholog0.68316552
106MP0000647_abnormal_sebaceous_gland0.67658439
107MP0001119_abnormal_female_reproductive0.67540382
108MP0003699_abnormal_female_reproductive0.65994475
109MP0002234_abnormal_pharynx_morphology0.65913241
110MP0000858_altered_metastatic_potential0.65807973
111MP0000716_abnormal_immune_system0.64613092
112MP0000477_abnormal_intestine_morphology0.63905491
113MP0002160_abnormal_reproductive_system0.63531019
114MP0004264_abnormal_extraembryonic_tissu0.63352728
115MP0003942_abnormal_urinary_system0.61867784
116MP0003941_abnormal_skin_development0.61727723
117MP0002081_perinatal_lethality0.61163265
118MP0002938_white_spotting0.61112655
119MP0002114_abnormal_axial_skeleton0.60556822
120MP0005391_vision/eye_phenotype0.59931576
121MP0003300_gastrointestinal_ulcer0.59350038
122MP0002161_abnormal_fertility/fecundity0.59276570
123MP0002075_abnormal_coat/hair_pigmentati0.58449444
124MP0003448_altered_tumor_morphology0.57695899
125MP0001529_abnormal_vocalization0.57213067
126MP0008770_decreased_survivor_rate0.56855197
127MP0003755_abnormal_palate_morphology0.55928075
128MP0003698_abnormal_male_reproductive0.55731653
129MP0000049_abnormal_middle_ear0.55703176
130MP0000762_abnormal_tongue_morphology0.55246588
131MP0002009_preneoplasia0.54961817
132MP0000266_abnormal_heart_morphology0.54350086
133MP0001177_atelectasis0.53933665

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.62998281
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33529675
3Cortical dysplasia (HP:0002539)4.10049506
4Volvulus (HP:0002580)3.73831481
5Abnormality of chromosome stability (HP:0003220)3.65479299
6Reticulocytopenia (HP:0001896)3.39336031
7Increased nuchal translucency (HP:0010880)3.30815300
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.25149792
9Short 4th metacarpal (HP:0010044)3.25149792
10Medulloblastoma (HP:0002885)3.20756142
11Birth length less than 3rd percentile (HP:0003561)3.20543347
12Ependymoma (HP:0002888)3.14696239
13Selective tooth agenesis (HP:0001592)3.06977794
14Impulsivity (HP:0100710)3.06327630
15Meckel diverticulum (HP:0002245)3.03580375
16Ectopic kidney (HP:0000086)3.02211553
17Colon cancer (HP:0003003)2.99832181
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.90349835
19Abnormality of the ileum (HP:0001549)2.87786749
20Abnormality of the preputium (HP:0100587)2.86020514
21Small intestinal stenosis (HP:0012848)2.83689753
22Duodenal stenosis (HP:0100867)2.83689753
23Proximal placement of thumb (HP:0009623)2.83614462
24Deviation of the thumb (HP:0009603)2.79047257
25Patellar aplasia (HP:0006443)2.75446711
26Myelodysplasia (HP:0002863)2.73627441
27Abnormality of the labia minora (HP:0012880)2.59672398
28Rhabdomyosarcoma (HP:0002859)2.59423744
29Aplasia/Hypoplasia of the patella (HP:0006498)2.58318012
30Embryonal neoplasm (HP:0002898)2.50296667
31Agnosia (HP:0010524)2.46871643
32Basal cell carcinoma (HP:0002671)2.42831315
33High pitched voice (HP:0001620)2.41797619
34Abnormal lung lobation (HP:0002101)2.40968475
35Nephroblastoma (Wilms tumor) (HP:0002667)2.39666530
36Cafe-au-lait spot (HP:0000957)2.39197933
37Abnormality of the astrocytes (HP:0100707)2.35489107
38Astrocytoma (HP:0009592)2.35489107
39Duplicated collecting system (HP:0000081)2.35414745
40Abnormality of the carotid arteries (HP:0005344)2.35305641
41Absent radius (HP:0003974)2.32168982
42Abnormality of the duodenum (HP:0002246)2.31857996
43Prominent nose (HP:0000448)2.31693500
44Breast hypoplasia (HP:0003187)2.31603353
45Triphalangeal thumb (HP:0001199)2.30327715
46Abnormal number of incisors (HP:0011064)2.30263191
47High anterior hairline (HP:0009890)2.28643367
4811 pairs of ribs (HP:0000878)2.27807519
49Abnormality of the 4th metacarpal (HP:0010012)2.27327402
50Absent thumb (HP:0009777)2.23830887
51Embryonal renal neoplasm (HP:0011794)2.23579880
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20278294
53Atresia of the external auditory canal (HP:0000413)2.20042622
54Glioma (HP:0009733)2.16354819
55Facial hemangioma (HP:0000329)2.16235812
56* Sloping forehead (HP:0000340)2.16107596
57Aplasia involving forearm bones (HP:0009822)2.14147047
58Absent forearm bone (HP:0003953)2.14147047
59Degeneration of anterior horn cells (HP:0002398)2.12735852
60Abnormality of the anterior horn cell (HP:0006802)2.12735852
61Choanal atresia (HP:0000453)2.12417530
62Neoplasm of the oral cavity (HP:0100649)2.11405166
63Abnormality of the renal collecting system (HP:0004742)2.10777329
64Long eyelashes (HP:0000527)2.10085560
65Abnormality of the fingertips (HP:0001211)2.09385075
66Duplication of thumb phalanx (HP:0009942)2.05785756
67Missing ribs (HP:0000921)2.04079422
68Biliary tract neoplasm (HP:0100574)2.03976047
69Squamous cell carcinoma (HP:0002860)2.02937842
70Abnormality of chromosome segregation (HP:0002916)2.02318150
71Neoplasm of the pancreas (HP:0002894)2.01718714
72Neoplasm of striated muscle (HP:0009728)2.01589371
73Bone marrow hypocellularity (HP:0005528)2.01449688
74Cutaneous melanoma (HP:0012056)2.00354007
75Abnormality of DNA repair (HP:0003254)1.98323100
76Malignant gastrointestinal tract tumors (HP:0006749)1.97152143
77Gastrointestinal carcinoma (HP:0002672)1.97152143
78Short thumb (HP:0009778)1.95044906
79Sandal gap (HP:0001852)1.95020058
80Broad distal phalanx of finger (HP:0009836)1.93658297
81Aplasia/Hypoplasia of the sternum (HP:0006714)1.93316767
82Tracheoesophageal fistula (HP:0002575)1.92355157
83Clubbing of toes (HP:0100760)1.90210328
84Ovarian neoplasm (HP:0100615)1.89224098
85Uterine leiomyosarcoma (HP:0002891)1.87342438
86Leiomyosarcoma (HP:0100243)1.87342438
87Cutis marmorata (HP:0000965)1.86766834
88Abnormality of the calcaneus (HP:0008364)1.86295266
89Carpal bone hypoplasia (HP:0001498)1.84166449
90Neoplasm of the colon (HP:0100273)1.82312808
91Microvesicular hepatic steatosis (HP:0001414)1.81072750
92Oral leukoplakia (HP:0002745)1.80579297
93Amaurosis fugax (HP:0100576)1.79664679
94Skull defect (HP:0001362)1.79093170
95Abnormality of cells of the erythroid lineage (HP:0012130)1.77924018
96Multiple enchondromatosis (HP:0005701)1.76322069
97Abnormality of cochlea (HP:0000375)1.75851989
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75642845
99Microglossia (HP:0000171)1.71521117
100Arteriovenous malformation (HP:0100026)1.70865883
101Broad palm (HP:0001169)1.70809310
102Supernumerary spleens (HP:0009799)1.70470648
103Progressive external ophthalmoplegia (HP:0000590)1.69314885
104Overlapping toe (HP:0001845)1.68862866
105Lymphoma (HP:0002665)1.68752886
106Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68166796
107Small epiphyses (HP:0010585)1.67824392
108Capillary hemangiomas (HP:0005306)1.67509644
109Truncal obesity (HP:0001956)1.67199893
110* Deep philtrum (HP:0002002)1.66914505
111Transitional cell carcinoma of the bladder (HP:0006740)1.66548843
112Blepharitis (HP:0000498)1.66365616
113Horseshoe kidney (HP:0000085)1.66047067
114Premature graying of hair (HP:0002216)1.65857305
115Renal duplication (HP:0000075)1.65067939
116Abnormal number of erythroid precursors (HP:0012131)1.64784324
117Poikiloderma (HP:0001029)1.64689573
118Acute myeloid leukemia (HP:0004808)1.64668647
119Long clavicles (HP:0000890)1.64013992
120Ankle contracture (HP:0006466)1.64010910
121Heterotopia (HP:0002282)1.63756834
122Spastic diplegia (HP:0001264)1.62421767
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.61080000
124Irregular epiphyses (HP:0010582)1.59310327
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.59210437
126Absent epiphyses (HP:0010577)1.59210437
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58807241
128Intestinal polyposis (HP:0200008)1.58375059
129Uterine neoplasm (HP:0010784)1.57914082
130Obsessive-compulsive behavior (HP:0000722)1.56488236
131Facial cleft (HP:0002006)1.55641655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.16800718
2WEE14.03299762
3BUB13.81279965
4NEK23.69833057
5CDK122.73735386
6TTK2.65525967
7NEK12.48696527
8SRPK12.28925794
9EEF2K2.28437711
10BRSK22.27783773
11PLK12.08072291
12AURKB2.01851276
13EIF2AK11.95152503
14ATR1.89925963
15STK41.80568371
16ACVR1B1.79618360
17MKNK11.77701800
18TLK11.76889239
19MAP3K101.75255497
20PLK31.74111110
21PASK1.71651146
22RPS6KB21.71240435
23STK101.70355960
24TAF11.69806773
25CDK41.66243902
26PKN21.65220698
27PLK41.58465350
28TSSK61.58379843
29MAP3K81.57782103
30CHEK21.56981046
31BRSK11.48841738
32CDK71.46736874
33CHEK11.46156731
34SCYL21.45967531
35CCNB11.45637772
36CDK61.38126900
37TESK21.37400922
38VRK21.31197043
39RPS6KA41.29989931
40VRK11.29530438
41MKNK21.28422589
42ZAK1.26799388
43SMG11.26068070
44BRAF1.23937781
45BRD41.22758540
46ATM1.18593228
47DYRK31.13633856
48STK31.09651974
49MELK1.08500427
50AURKA1.02801357
51TGFBR11.02567064
52* CDK20.96136146
53PAK40.88717943
54PIM10.87750366
55CLK10.86085613
56FLT30.84268925
57* CDK10.81759082
58ALK0.79705360
59EIF2AK30.79285206
60TTN0.74923535
61LRRK20.72256571
62MAP4K10.71915487
63LATS10.68216362
64TRIM280.66362647
65MTOR0.62441135
66MET0.61786172
67EPHA20.60070123
68ERBB40.58920319
69EIF2AK20.57428044
70BCR0.56831458
71RPS6KA50.54650051
72NUAK10.52932843
73CDK90.52056127
74LATS20.52023329
75PNCK0.51530514
76MST40.50818578
77NEK90.50618231
78PRKDC0.50424470
79MST1R0.49558115
80TESK10.49427451
81TRIB30.49231525
82CSNK2A20.49033914
83ICK0.47987520
84NME20.47189228
85GRK60.46380713
86CSNK1D0.45317160
87FGFR10.45043227
88CSNK2A10.43795589
89CDK30.42243644
90PAK10.41012319
91MARK30.39587223
92* MAPK140.38369844
93PAK20.37393566
94CSF1R0.36596614
95PTK60.36192507
96AKT20.36054192
97CAMK1G0.35365854
98STK38L0.33975609
99KSR10.33479333
100TRPM70.31910878
101* CDK180.31288490
102AKT10.31130154
103ERBB30.30029114
104* CDK11A0.29847044
105* CDK150.29592910
106UHMK10.29392449
107YES10.29279197
108CSNK1E0.28334828
109CAMK1D0.27902382
110MAPK10.25725137
111BTK0.25691280
112* CDK140.25381712
113RAF10.24126436
114GSK3B0.23850655
115PBK0.23351060
116RPS6KB10.22495649
117STK160.22382505
118PRKCI0.21029244
119CDK80.20767769
120PDGFRA0.19372461
121RPS6KC10.18014693
122RPS6KL10.18014693
123MAPK110.17700067
124DYRK1B0.17342349
125PLK20.16499697
126CSNK1G10.11561877

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.96412777
2Mismatch repair_Homo sapiens_hsa034304.27264656
3Cell cycle_Homo sapiens_hsa041103.45726980
4Spliceosome_Homo sapiens_hsa030403.07787044
5Homologous recombination_Homo sapiens_hsa034403.07200481
6RNA transport_Homo sapiens_hsa030133.00479205
7Base excision repair_Homo sapiens_hsa034102.99627153
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92564575
9Nucleotide excision repair_Homo sapiens_hsa034202.75455630
10Fanconi anemia pathway_Homo sapiens_hsa034602.69954822
11One carbon pool by folate_Homo sapiens_hsa006702.65649332
12Non-homologous end-joining_Homo sapiens_hsa034502.63889608
13Systemic lupus erythematosus_Homo sapiens_hsa053222.55018364
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19645216
15mRNA surveillance pathway_Homo sapiens_hsa030152.09553050
16Ribosome_Homo sapiens_hsa030101.92437197
17p53 signaling pathway_Homo sapiens_hsa041151.90278991
18RNA degradation_Homo sapiens_hsa030181.78765639
19RNA polymerase_Homo sapiens_hsa030201.76259058
20Pyrimidine metabolism_Homo sapiens_hsa002401.67298464
21Viral carcinogenesis_Homo sapiens_hsa052031.62993068
22Basal transcription factors_Homo sapiens_hsa030221.52558685
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41191721
24Oocyte meiosis_Homo sapiens_hsa041141.37887219
25Proteasome_Homo sapiens_hsa030501.31982001
26MicroRNAs in cancer_Homo sapiens_hsa052061.28753087
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26408069
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23088449
29Alcoholism_Homo sapiens_hsa050341.22906945
30Epstein-Barr virus infection_Homo sapiens_hsa051691.17854985
31Antigen processing and presentation_Homo sapiens_hsa046121.17448171
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15221450
33Herpes simplex infection_Homo sapiens_hsa051681.14349926
34HTLV-I infection_Homo sapiens_hsa051661.11718636
35Small cell lung cancer_Homo sapiens_hsa052221.08100124
36Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98108399
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97353559
38Pyruvate metabolism_Homo sapiens_hsa006200.96645068
39Primary immunodeficiency_Homo sapiens_hsa053400.89244551
40Chronic myeloid leukemia_Homo sapiens_hsa052200.88554776
41Carbon metabolism_Homo sapiens_hsa012000.88102221
42Folate biosynthesis_Homo sapiens_hsa007900.87202062
43Steroid biosynthesis_Homo sapiens_hsa001000.84129750
44Colorectal cancer_Homo sapiens_hsa052100.83861861
45Vitamin B6 metabolism_Homo sapiens_hsa007500.79768745
46Protein export_Homo sapiens_hsa030600.78604354
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78007063
48Purine metabolism_Homo sapiens_hsa002300.76910354
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74919200
50Thyroid cancer_Homo sapiens_hsa052160.73968789
51Selenocompound metabolism_Homo sapiens_hsa004500.72653370
52Hepatitis B_Homo sapiens_hsa051610.70922023
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66067173
54Lysine degradation_Homo sapiens_hsa003100.65681146
55Adherens junction_Homo sapiens_hsa045200.65224530
56Apoptosis_Homo sapiens_hsa042100.64626231
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64320016
58Viral myocarditis_Homo sapiens_hsa054160.63395669
59TGF-beta signaling pathway_Homo sapiens_hsa043500.63384923
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63187943
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60822341
62Hippo signaling pathway_Homo sapiens_hsa043900.60229852
63Basal cell carcinoma_Homo sapiens_hsa052170.59870462
64Non-small cell lung cancer_Homo sapiens_hsa052230.59656763
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.58175156
66Prostate cancer_Homo sapiens_hsa052150.57775058
67Pancreatic cancer_Homo sapiens_hsa052120.57509255
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56942550
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56822330
70mTOR signaling pathway_Homo sapiens_hsa041500.56753247
71Measles_Homo sapiens_hsa051620.56060751
72Legionellosis_Homo sapiens_hsa051340.55023743
73Pentose phosphate pathway_Homo sapiens_hsa000300.54212150
74Notch signaling pathway_Homo sapiens_hsa043300.49900897
75Propanoate metabolism_Homo sapiens_hsa006400.49854863
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.49557392
77B cell receptor signaling pathway_Homo sapiens_hsa046620.48087506
78Pathways in cancer_Homo sapiens_hsa052000.47505301
79Biosynthesis of amino acids_Homo sapiens_hsa012300.46198908
80Bladder cancer_Homo sapiens_hsa052190.45471045
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44531853
82FoxO signaling pathway_Homo sapiens_hsa040680.44187105
83Proteoglycans in cancer_Homo sapiens_hsa052050.44014538
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43239866
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.42796283
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42538068
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41231674
88Shigellosis_Homo sapiens_hsa051310.41169600
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41025813
90Influenza A_Homo sapiens_hsa051640.40778480
91Fatty acid elongation_Homo sapiens_hsa000620.39612585
92Hematopoietic cell lineage_Homo sapiens_hsa046400.39293959
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39256249
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39056866
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38969155
96Endometrial cancer_Homo sapiens_hsa052130.38830432
97HIF-1 signaling pathway_Homo sapiens_hsa040660.37995306
98Sulfur relay system_Homo sapiens_hsa041220.37702628
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34433606
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.33622124
101Acute myeloid leukemia_Homo sapiens_hsa052210.33263622
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32892486
103N-Glycan biosynthesis_Homo sapiens_hsa005100.31064657
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.30564693
105T cell receptor signaling pathway_Homo sapiens_hsa046600.30078401
106Hedgehog signaling pathway_Homo sapiens_hsa043400.30036400
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29131481
108Melanoma_Homo sapiens_hsa052180.27683489
109Glutathione metabolism_Homo sapiens_hsa004800.27105066
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.26625908
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.25833004
112Leishmaniasis_Homo sapiens_hsa051400.25544417
113Wnt signaling pathway_Homo sapiens_hsa043100.25496129
114Toxoplasmosis_Homo sapiens_hsa051450.24356698
115Focal adhesion_Homo sapiens_hsa045100.24025707
116Renin-angiotensin system_Homo sapiens_hsa046140.23935453
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23569381
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23003734
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22285570
120Platelet activation_Homo sapiens_hsa046110.21928113
121Fatty acid metabolism_Homo sapiens_hsa012120.21450211
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20534646
123Glioma_Homo sapiens_hsa052140.19939272
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.19708124
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19054164
126AMPK signaling pathway_Homo sapiens_hsa041520.19027242
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18286957
128Tight junction_Homo sapiens_hsa045300.17004214
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.16181268
130Metabolic pathways_Homo sapiens_hsa011000.11731774
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.11394674

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