KIF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kinesin superfamily of microtubule-associated molecular motors with functions related to the microtubule cytosekelton. Members of this superfamily play important roles in intracellular transport and cell division. A similar protein in mouse functions in the beta cell antioxidant signaling cascade, acting as a scaffold for the transcription factor specificity protein 1 (Sp1). Mice that lack this gene exhibit beta cell oxidative stress resulting in hypoinsulinemic glucose intolerance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein kinase C signaling (GO:0090037)7.74771029
2endocrine pancreas development (GO:0031018)7.37227301
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.86124114
4peptide hormone processing (GO:0016486)6.40951480
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.29320928
6protein retention in ER lumen (GO:0006621)6.25142119
7COPII vesicle coating (GO:0048208)6.22754139
8protein maturation by protein folding (GO:0022417)6.00963898
9glandular epithelial cell differentiation (GO:0002067)5.44435657
10exocrine pancreas development (GO:0031017)5.32102188
11positive regulation of insulin secretion (GO:0032024)5.30788728
12regulation of type B pancreatic cell apoptotic process (GO:2000674)5.26316329
13regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.18247123
14signal peptide processing (GO:0006465)5.00471399
15negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.97063369
16type B pancreatic cell development (GO:0003323)4.93690009
17cellular response to vitamin D (GO:0071305)4.91068013
18insulin secretion (GO:0030073)4.90132191
19activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.88646466
20glandular epithelial cell development (GO:0002068)4.74269648
21sequestering of metal ion (GO:0051238)4.73956299
22L-alpha-amino acid transmembrane transport (GO:1902475)4.63769763
23positive regulation of nuclease activity (GO:0032075)4.63347516
24vesicle coating (GO:0006901)4.61085329
25regulation of insulin secretion (GO:0050796)4.39502927
26toxin metabolic process (GO:0009404)4.36000763
27regulation of hydrogen peroxide metabolic process (GO:0010310)4.35459824
28positive regulation of peptide hormone secretion (GO:0090277)4.29215680
29regulation of nuclease activity (GO:0032069)4.21053445
30tricarboxylic acid metabolic process (GO:0072350)4.15494929
31negative regulation of cell size (GO:0045792)4.13914435
32positive regulation of peptide secretion (GO:0002793)4.12959743
33endoplasmic reticulum unfolded protein response (GO:0030968)4.05663365
34regulation of peptide hormone secretion (GO:0090276)4.00281072
35cellular response to unfolded protein (GO:0034620)3.97379876
36nitric oxide mediated signal transduction (GO:0007263)3.95111140
37regulation of protein kinase C signaling (GO:0090036)3.92588134
38regulation of peptide secretion (GO:0002791)3.92234397
39negative regulation of glycoprotein biosynthetic process (GO:0010561)3.91987521
40cellular response to topologically incorrect protein (GO:0035967)3.90748697
41semaphorin-plexin signaling pathway (GO:0071526)3.90286631
42drug transmembrane transport (GO:0006855)3.88019788
43peptide hormone secretion (GO:0030072)3.87980578
44ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.84342849
45regulation of ARF GTPase activity (GO:0032312)3.82804170
46epoxygenase P450 pathway (GO:0019373)3.79846545
47peptide secretion (GO:0002790)3.79728853
48ER-nucleus signaling pathway (GO:0006984)3.79431597
49columnar/cuboidal epithelial cell development (GO:0002066)3.75169801
50endothelial cell morphogenesis (GO:0001886)3.72016033
51desmosome organization (GO:0002934)3.66070760
52macroautophagy (GO:0016236)3.61588722
53regulation of plasminogen activation (GO:0010755)3.61458963
54epithelial cell fate commitment (GO:0072148)3.60419992
55negative regulation of insulin secretion (GO:0046676)3.53906456
56intra-Golgi vesicle-mediated transport (GO:0006891)3.53080722
57positive regulation of glycolytic process (GO:0045821)3.52755859
58cellular response to vitamin (GO:0071295)3.51918773
59white fat cell differentiation (GO:0050872)3.49526170
60quaternary ammonium group transport (GO:0015697)3.48541603
61renal absorption (GO:0070293)3.43706164
62regulation of hormone secretion (GO:0046883)3.43287980
63ER overload response (GO:0006983)3.42698120
64mannose metabolic process (GO:0006013)3.42590878
65urogenital system development (GO:0001655)3.36573631
66cellular zinc ion homeostasis (GO:0006882)3.36170255
67protein N-linked glycosylation via asparagine (GO:0018279)3.35917184
68ER to Golgi vesicle-mediated transport (GO:0006888)3.34603105
69peptidyl-asparagine modification (GO:0018196)3.34239186
70response to endoplasmic reticulum stress (GO:0034976)3.33539877
71astrocyte differentiation (GO:0048708)3.32692384
72triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.31804708
73cellular response to hepatocyte growth factor stimulus (GO:0035729)3.31628957
74response to hepatocyte growth factor (GO:0035728)3.31628957
75positive regulation of hormone secretion (GO:0046887)3.30890985
76response to hexose (GO:0009746)3.29304756
77phosphate ion transport (GO:0006817)3.27195479
78membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.26300780
79protein autoprocessing (GO:0016540)3.25500144
80response to glucose (GO:0009749)3.25156565
81metanephric nephron epithelium development (GO:0072243)3.21505699
82regulation of peptide transport (GO:0090087)3.21451713
83endothelial cell chemotaxis (GO:0035767)3.21280250
844-hydroxyproline metabolic process (GO:0019471)3.20979264
85positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.20859230
86detection of calcium ion (GO:0005513)3.20825135
87peptide transport (GO:0015833)3.18968993
88positive regulation of histone deacetylation (GO:0031065)3.18073130
89negative regulation of catecholamine secretion (GO:0033604)3.17082813
90vascular endothelial growth factor signaling pathway (GO:0038084)3.15438156
91negative regulation of norepinephrine secretion (GO:0010700)3.13979821
92drug transport (GO:0015893)3.13962633
93cell-cell junction maintenance (GO:0045217)3.13660484
94response to mercury ion (GO:0046689)3.13154780
95response to monosaccharide (GO:0034284)3.12646228
96regulation of Golgi to plasma membrane protein transport (GO:0042996)3.10387632
97phosphate ion transmembrane transport (GO:0035435)3.08649377
98hormone secretion (GO:0046879)3.08475261
99protein N-linked glycosylation (GO:0006487)3.07989385
100response to unfolded protein (GO:0006986)3.07931969
101growth hormone secretion (GO:0030252)3.07348949
102negative regulation of peptide hormone secretion (GO:0090278)3.06660928
103peptide metabolic process (GO:0006518)3.05626228
104peptide catabolic process (GO:0043171)3.05400026
105cell volume homeostasis (GO:0006884)3.05126454
106regulation of cholesterol metabolic process (GO:0090181)3.04558338
107peptidyl-glutamic acid carboxylation (GO:0017187)3.04420561
108protein carboxylation (GO:0018214)3.04420561
109Golgi organization (GO:0007030)3.04225298
110insulin-like growth factor receptor signaling pathway (GO:0048009)3.04071903
111glucose homeostasis (GO:0042593)3.04042340
112carbohydrate homeostasis (GO:0033500)3.04042340
113positive regulation of cellular amine metabolic process (GO:0033240)3.03882713
114response to topologically incorrect protein (GO:0035966)3.03104340
115actin filament depolymerization (GO:0030042)3.02234080
116drug catabolic process (GO:0042737)3.01360558
117toxin transport (GO:1901998)3.00564571
118metanephric nephron tubule development (GO:0072234)2.99721465
119metanephric tubule development (GO:0072170)2.99721465
120erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98982486
121L-phenylalanine catabolic process (GO:0006559)2.98982486
122neuron remodeling (GO:0016322)2.98451862
123intestinal absorption (GO:0050892)2.98102255
124hormone transport (GO:0009914)2.97948681
125ear development (GO:0043583)2.97288953
126lung epithelium development (GO:0060428)2.95274714
127negative regulation of peptide secretion (GO:0002792)2.95109648
128negative regulation of glycoprotein metabolic process (GO:1903019)2.94550805
129urate metabolic process (GO:0046415)2.94217374
130cellular response to glucagon stimulus (GO:0071377)2.93743204
131trivalent inorganic anion homeostasis (GO:0072506)2.92629500
132phosphate ion homeostasis (GO:0055062)2.92629500
133peptidyl-tyrosine autophosphorylation (GO:0038083)2.91304094
134nephron epithelium morphogenesis (GO:0072088)2.91275792
135nephron tubule morphogenesis (GO:0072078)2.91275792
136intestinal cholesterol absorption (GO:0030299)2.90073832
137atrioventricular valve morphogenesis (GO:0003181)2.88866776
138regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.88211932
139metanephric epithelium development (GO:0072207)2.88085761
140cellular response to nutrient (GO:0031670)2.87831611
141membrane repolarization during action potential (GO:0086011)2.87729717
142protein localization to Golgi apparatus (GO:0034067)2.87608206
143organic cation transport (GO:0015695)2.87474650
144regulation of protein activation cascade (GO:2000257)2.85691778
145positive regulation of hormone metabolic process (GO:0032352)2.85490850
146regulation of complement activation (GO:0030449)2.82275392
147high-density lipoprotein particle remodeling (GO:0034375)2.82220765
148regulation of apoptotic cell clearance (GO:2000425)2.82150073
149urea metabolic process (GO:0019627)2.78574457
150L-phenylalanine metabolic process (GO:0006558)2.77022733
151erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.77022733
152regulation of ruffle assembly (GO:1900027)2.73848553
153phospholipid efflux (GO:0033700)2.71754042
154regulation of triglyceride catabolic process (GO:0010896)2.71584723
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70656886
156urea cycle (GO:0000050)2.70457530
157cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70300230
158positive regulation of lipoprotein lipase activity (GO:0051006)2.70257103
159positive regulation of triglyceride lipase activity (GO:0061365)2.70257103
160histone H3-K9 demethylation (GO:0033169)2.70101124
161phenylpropanoid metabolic process (GO:0009698)2.69658468
162chondroitin sulfate catabolic process (GO:0030207)2.64319386
163gonadal mesoderm development (GO:0007506)2.62673614
164drug metabolic process (GO:0017144)2.62011875
165regulation of fibrinolysis (GO:0051917)2.61510917
166cell junction maintenance (GO:0034331)2.61292698
167nephron tubule development (GO:0072080)2.61219587
168negative regulation of digestive system process (GO:0060457)2.59320928
169ethanol oxidation (GO:0006069)2.58874603
170regulation of extracellular matrix disassembly (GO:0010715)2.58594971
171sulfur amino acid catabolic process (GO:0000098)2.54521883
172negative regulation of catenin import into nucleus (GO:0035414)2.51292167
173complement activation, alternative pathway (GO:0006957)2.50620759
174branching involved in salivary gland morphogenesis (GO:0060445)2.50583048
175lymph vessel development (GO:0001945)2.49915851
176reverse cholesterol transport (GO:0043691)2.48711537
177histone H4 deacetylation (GO:0070933)2.47914624
178epithelial cell-cell adhesion (GO:0090136)2.47675711
179collecting duct development (GO:0072044)2.47164551
180regulation of cholesterol biosynthetic process (GO:0045540)2.47022429
181protein-lipid complex remodeling (GO:0034368)2.46504476
182macromolecular complex remodeling (GO:0034367)2.46504476
183plasma lipoprotein particle remodeling (GO:0034369)2.46504476
184regulation of synapse maturation (GO:0090128)2.46169917
185Golgi transport vesicle coating (GO:0048200)10.3200346
186COPI coating of Golgi vesicle (GO:0048205)10.3200346

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.15998956
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.00925827
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.78688011
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.65589928
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.37245286
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.81299436
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.61048852
8DROSHA_22980978_ChIP-Seq_HELA_Human2.59597184
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55132616
10RACK7_27058665_Chip-Seq_MCF-7_Human2.41118035
11ZNF263_19887448_ChIP-Seq_K562_Human2.33743478
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.32908223
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.29039961
14* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.26004820
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.11418939
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.07200064
17P68_20966046_ChIP-Seq_HELA_Human2.05366994
18CTCF_27219007_Chip-Seq_Bcells_Human2.02310024
19RUNX1_27514584_Chip-Seq_MCF-7_Human2.01251777
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.0221813
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95588086
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.94591876
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94475250
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.93326327
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87196257
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82057131
27* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81546075
28KDM2B_26808549_Chip-Seq_K562_Human1.79536598
29EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76322700
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.74763867
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.69464766
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66318999
33SMC4_20622854_ChIP-Seq_HELA_Human1.66301432
34CLOCK_20551151_ChIP-Seq_293T_Human1.64281445
35TCF7_22412390_ChIP-Seq_EML_Mouse1.62777344
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61797314
37FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.61557686
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.59267802
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58308720
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56425875
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55545074
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51821545
43BCOR_27268052_Chip-Seq_Bcells_Human1.51559430
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.50479936
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49171390
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48015197
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.47046678
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46793445
49FOXA1_25552417_ChIP-Seq_VCAP_Human1.43237247
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42393836
51IGF1R_20145208_ChIP-Seq_DFB_Human1.40498612
52AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39113804
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37513526
54E2F1_20622854_ChIP-Seq_HELA_Human1.36656036
55BCL6_27268052_Chip-Seq_Bcells_Human1.35631913
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35560442
57KDM2B_26808549_Chip-Seq_DND41_Human1.34977371
58TFEB_21752829_ChIP-Seq_HELA_Human1.30522376
59GATA1_19941826_ChIP-Seq_K562_Human1.30505038
60* TP63_22573176_ChIP-Seq_HFKS_Human1.29625371
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.29378579
62GATA4_25053715_ChIP-Seq_YYC3_Human1.28924286
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28472335
64RARB_24833708_ChIP-Seq_LIVER_Mouse1.27645057
65SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27468359
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27227006
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26298923
68PHF8_20622854_ChIP-Seq_HELA_Human1.25784487
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24921803
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24513081
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24342375
72ZNF274_21170338_ChIP-Seq_K562_Hela1.22767849
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21496913
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.20470760
75REST_19997604_ChIP-ChIP_NEURONS_Mouse1.19878879
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19446552
77* TET1_21490601_ChIP-Seq_MESCs_Mouse1.19009070
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18663914
79TP53_22127205_ChIP-Seq_IMR90_Human1.18328152
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17376692
81VDR_22108803_ChIP-Seq_LS180_Human1.17355594
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.16449039
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15753794
84RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14420645
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.14235776
86SOX2_20726797_ChIP-Seq_SW620_Human1.13436793
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12061472
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11339460
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.11206199
90* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10097773
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09601605
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08885220
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.07717482
94REST_21632747_ChIP-Seq_MESCs_Mouse1.07373387
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07074427
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07005299
97ERG_20517297_ChIP-Seq_VCAP_Human1.06444449
98GATA6_25053715_ChIP-Seq_YYC3_Human1.06328561
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06303816
100EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05853510
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05571369
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05556528
103SA1_27219007_Chip-Seq_Bcells_Human1.05069035
104JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04549809
105RARA_24833708_ChIP-Seq_LIVER_Mouse1.04129153
106* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03331641
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.02777634
108* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02776610
109* REST_18959480_ChIP-ChIP_MESCs_Mouse1.01090084
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00834525
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00441408
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99997459
113* KLF5_25053715_ChIP-Seq_YYC3_Human0.99961857
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99793218
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99366164
116CTCF_20526341_ChIP-Seq_ESCs_Human0.96822175
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96402710
118SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96268641
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96079724
120VDR_21846776_ChIP-Seq_THP-1_Human0.95983042
121OCT4_19829295_ChIP-Seq_ESCs_Human0.95795442
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95685798
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95103246
124TP53_22573176_ChIP-Seq_HFKS_Human0.94791690
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94100369
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.92659508
127LXR_22292898_ChIP-Seq_THP-1_Human0.92625519
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92523593
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92483839
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92456318
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92373644
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91153237
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90753701
134ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90083755
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.90048780
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89772655
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89410769
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89318877
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.88529856
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88330010
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88267323
142RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87334489
143CREB1_26743006_Chip-Seq_LNCaP_Human0.86846950
144CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85696980
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.83246303
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.83246303
147* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81501869
148FOXH1_21741376_ChIP-Seq_ESCs_Human0.81028195
149ESR2_21235772_ChIP-Seq_MCF-7_Human0.80793869
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80186685
151CHD1_26751641_Chip-Seq_LNCaP_Human0.80063809
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79580495
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78988864
154ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77987479
155TET1_21451524_ChIP-Seq_MESCs_Mouse0.77131961
156AR_20517297_ChIP-Seq_VCAP_Human0.77055688
157E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.77017060
158SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76671576
159TDRD3_21172665_ChIP-Seq_MCF-7_Human0.75338051
160TRIM28_21343339_ChIP-Seq_HEK293_Human0.75080636
161MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.73871660
162GATA3_27048872_Chip-Seq_THYMUS_Human0.73621413
163GABP_17652178_ChIP-ChIP_JURKAT_Human0.73063586
164PKCTHETA_26484144_Chip-Seq_BREAST_Human0.72490206
165CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72084157
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71809208
167GF1B_26923725_Chip-Seq_HPCs_Mouse0.71288116
168FOXO3_23340844_ChIP-Seq_DLD1_Human0.70874101
169PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70104934
170E2F1_17053090_ChIP-ChIP_MCF-7_Human0.69981343
171FOXA1_27270436_Chip-Seq_PROSTATE_Human0.69465118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation5.11875985
2MP0003283_abnormal_digestive_organ4.81840003
3MP0003195_calcinosis4.65143654
4MP0002877_abnormal_melanocyte_morpholog4.44000714
5MP0005409_darkened_coat_color4.16650486
6MP0000013_abnormal_adipose_tissue4.05905993
7MP0002693_abnormal_pancreas_physiology3.79981222
8MP0001944_abnormal_pancreas_morphology3.66703622
9MP0002909_abnormal_adrenal_gland3.45200196
10MP0003183_abnormal_peptide_metabolism3.33988704
11MP0009780_abnormal_chondrocyte_physiolo3.33571987
12MP0003136_yellow_coat_color3.31678549
13MP0005220_abnormal_exocrine_pancreas3.19322083
14MP0005379_endocrine/exocrine_gland_phen3.10242916
15MP0000678_abnormal_parathyroid_gland3.06281955
16MP0002138_abnormal_hepatobiliary_system2.96239191
17MP0010386_abnormal_urinary_bladder2.84940412
18MP0001188_hyperpigmentation2.61700945
19MP0002249_abnormal_larynx_morphology2.59811767
20MP0004381_abnormal_hair_follicle2.53772813
21MP0001765_abnormal_ion_homeostasis2.40506866
22MP0002928_abnormal_bile_duct2.29543889
23MP0002837_dystrophic_cardiac_calcinosis2.28271814
24MP0004264_abnormal_extraembryonic_tissu2.24464420
25MP0002078_abnormal_glucose_homeostasis2.24275040
26MP0009643_abnormal_urine_homeostasis2.21232663
27MP0000003_abnormal_adipose_tissue2.17370572
28MP0010368_abnormal_lymphatic_system2.12365828
29MP0002139_abnormal_hepatobiliary_system2.11593767
30MP0000566_synostosis2.06869086
31MP0003300_gastrointestinal_ulcer2.03634961
32MP0003705_abnormal_hypodermis_morpholog2.00049073
33MP0001756_abnormal_urination1.97716560
34MP0006292_abnormal_olfactory_placode1.89948760
35MP0003252_abnormal_bile_duct1.89168351
36MP0005365_abnormal_bile_salt1.87814079
37MP0001849_ear_inflammation1.86341459
38MP0008961_abnormal_basal_metabolism1.80764580
39MP0005636_abnormal_mineral_homeostasis1.73099176
40MP0003122_maternal_imprinting1.70959259
41MP0006072_abnormal_retinal_apoptosis1.70738936
42MP0010329_abnormal_lipoprotein_level1.66642124
43MP0005084_abnormal_gallbladder_morpholo1.63140137
44MP0009384_cardiac_valve_regurgitation1.60619617
45MP0005645_abnormal_hypothalamus_physiol1.59806211
46MP0000467_abnormal_esophagus_morphology1.58568496
47MP0002896_abnormal_bone_mineralization1.57102124
48MP0005058_abnormal_lysosome_morphology1.55836170
49MP0002822_catalepsy1.55097294
50MP0000462_abnormal_digestive_system1.53930907
51MP0003172_abnormal_lysosome_physiology1.47725562
52MP0004019_abnormal_vitamin_homeostasis1.44310504
53MP0005332_abnormal_amino_acid1.40418435
54MP0002234_abnormal_pharynx_morphology1.38590068
55MP0003953_abnormal_hormone_level1.38157426
56MP0002638_abnormal_pupillary_reflex1.37610156
57MP0003959_abnormal_lean_body1.37336264
58MP0005503_abnormal_tendon_morphology1.36873173
59MP0005360_urolithiasis1.31939481
60MP0001986_abnormal_taste_sensitivity1.28264488
61MP0005646_abnormal_pituitary_gland1.27756751
62MP0000613_abnormal_salivary_gland1.20116389
63MP0001666_abnormal_nutrient_absorption1.19225181
64MP0003868_abnormal_feces_composition1.18670248
65MP0002933_joint_inflammation1.17462990
66MP0002163_abnormal_gland_morphology1.15466456
67MP0009840_abnormal_foam_cell1.12278314
68MP0002796_impaired_skin_barrier1.10284852
69MP0000015_abnormal_ear_pigmentation1.10172245
70MP0006054_spinal_hemorrhage1.10164144
71MP0005375_adipose_tissue_phenotype1.08908173
72MP0005076_abnormal_cell_differentiation1.08776275
73MP0000538_abnormal_urinary_bladder1.07366691
74MP0005257_abnormal_intraocular_pressure1.06323831
75MP0005535_abnormal_body_temperature1.05923618
76MP0001270_distended_abdomen1.03956488
77MP0003279_aneurysm0.99618693
78MP0003878_abnormal_ear_physiology0.98589101
79MP0005377_hearing/vestibular/ear_phenot0.98589101
80MP0000230_abnormal_systemic_arterial0.97943014
81MP0002876_abnormal_thyroid_physiology0.96262697
82MP0004270_analgesia0.94965285
83MP0000767_abnormal_smooth_muscle0.93313571
84MP0000371_diluted_coat_color0.93102241
85MP0003119_abnormal_digestive_system0.93075007
86MP0002282_abnormal_trachea_morphology0.89339140
87MP0003453_abnormal_keratinocyte_physiol0.89304168
88MP0005670_abnormal_white_adipose0.88858531
89MP0000631_abnormal_neuroendocrine_gland0.87881190
90MP0003938_abnormal_ear_development0.87656774
91MP0001764_abnormal_homeostasis0.87569388
92MP0008260_abnormal_autophagy0.86723253
93MP0000383_abnormal_hair_follicle0.86684321
94MP0005174_abnormal_tail_pigmentation0.86077282
95MP0005595_abnormal_vascular_smooth0.85147019
96MP0002132_abnormal_respiratory_system0.84937486
97MP0004272_abnormal_basement_membrane0.84535520
98MP0001958_emphysema0.82892785
99MP0002136_abnormal_kidney_physiology0.82332479
100MP0005666_abnormal_adipose_tissue0.82086784
101MP0001348_abnormal_lacrimal_gland0.81298523
102MP0002168_other_aberrant_phenotype0.80813657
103MP0005310_abnormal_salivary_gland0.80619171
104MP0002932_abnormal_joint_morphology0.80571535
105MP0003045_fibrosis0.79870127
106MP0010678_abnormal_skin_adnexa0.78509711
107MP0003115_abnormal_respiratory_system0.74823934
108MP0005408_hypopigmentation0.74817708
109MP0002118_abnormal_lipid_homeostasis0.74111576
110MP0005085_abnormal_gallbladder_physiolo0.73190949
111MP0004782_abnormal_surfactant_physiolog0.72917738
112MP0003866_abnormal_defecation0.71719713
113MP0001661_extended_life_span0.71543525
114MP0005448_abnormal_energy_balance0.71351381
115MP0002254_reproductive_system_inflammat0.71135148
116MP0002108_abnormal_muscle_morphology0.69958545
117MP0010234_abnormal_vibrissa_follicle0.69631680
118MP0008872_abnormal_physiological_respon0.69442137
119MP0003942_abnormal_urinary_system0.68558859
120MP0009672_abnormal_birth_weight0.68414873
121MP0009642_abnormal_blood_homeostasis0.68326089
122MP0004133_heterotaxia0.68056041
123MP0005083_abnormal_biliary_tract0.65123135
124MP0000751_myopathy0.64730175
125MP0003787_abnormal_imprinting0.64442197
126MP0003123_paternal_imprinting0.64397491
127MP0006138_congestive_heart_failure0.64346089
128MP0000639_abnormal_adrenal_gland0.63407095
129MP0003879_abnormal_hair_cell0.62765121
130MP0001299_abnormal_eye_distance/0.58270118
131MP0002938_white_spotting0.57105896
132MP0001664_abnormal_digestion0.57028280
133MP0001502_abnormal_circadian_rhythm0.55970833
134MP0006036_abnormal_mitochondrial_physio0.54668644
135MP0002069_abnormal_eating/drinking_beha0.54426264
136MP0003795_abnormal_bone_structure0.52463384
137MP0009703_decreased_birth_body0.51777590
138MP0005187_abnormal_penis_morphology0.48317868
139MP0000163_abnormal_cartilage_morphology0.48064900
140MP0005452_abnormal_adipose_tissue0.47234678
141MP0000609_abnormal_liver_physiology0.46980924
142MP0004885_abnormal_endolymph0.46704087
143MP0005253_abnormal_eye_physiology0.46396967
144MP0003890_abnormal_embryonic-extraembry0.45757067
145MP0008875_abnormal_xenobiotic_pharmacok0.45543069
146MP0001731_abnormal_postnatal_growth0.45086724
147MP0003943_abnormal_hepatobiliary_system0.44087446
148MP0000681_abnormal_thyroid_gland0.43284800
149MP0004233_abnormal_muscle_weight0.42995096

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.59335970
2Hypoglycemic seizures (HP:0002173)7.07807434
3Hypoglycemic coma (HP:0001325)6.59920817
4Symptomatic seizures (HP:0011145)6.50294890
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.42083637
6J-shaped sella turcica (HP:0002680)6.12087786
7Lymphangioma (HP:0100764)5.45441909
8Ketoacidosis (HP:0001993)5.35731745
9Late onset (HP:0003584)4.75787384
10Hyperglycemia (HP:0003074)4.74404333
11Abnormality of the pancreatic islet cells (HP:0006476)4.61613041
12Abnormality of endocrine pancreas physiology (HP:0012093)4.61613041
13Abnormality of calcium-phosphate metabolism (HP:0100530)4.61188638
14Pancreatic islet-cell hyperplasia (HP:0004510)4.59202138
15Gout (HP:0001997)4.58334472
16Nuclear cataract (HP:0100018)4.41223122
17Insulin-resistant diabetes mellitus (HP:0000831)4.32013380
18Increased circulating renin level (HP:0000848)4.31693112
19Hyperactive renin-angiotensin system (HP:0000841)4.04028270
20Generalized aminoaciduria (HP:0002909)4.02509166
21Large for gestational age (HP:0001520)4.01826329
22Hypokalemia (HP:0002900)4.00443526
23Abnormal pancreas size (HP:0012094)3.96670819
24Abnormality of renin-angiotensin system (HP:0000847)3.74540665
25Hypokalemic alkalosis (HP:0001949)3.72226595
26Decreased circulating renin level (HP:0003351)3.63063345
27Cervical subluxation (HP:0003308)3.62720974
28Abnormality of chloride homeostasis (HP:0011422)3.61752849
29Obstructive sleep apnea (HP:0002870)3.56857894
30Visceral angiomatosis (HP:0100761)3.54911463
31Broad face (HP:0000283)3.44239415
32Ketosis (HP:0001946)3.40491104
33Dysostosis multiplex (HP:0000943)3.29214913
34Deformed sella turcica (HP:0002681)3.26968635
35Polyuria (HP:0000103)3.26308364
36Urinary glycosaminoglycan excretion (HP:0003541)3.26183703
37Mucopolysacchariduria (HP:0008155)3.26183703
38Abnormality of potassium homeostasis (HP:0011042)3.23614803
39Hypomagnesemia (HP:0002917)3.23274096
40Hemangiomatosis (HP:0007461)3.22627186
41Neoplasm of the heart (HP:0100544)3.11541346
42Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09729938
43Deep venous thrombosis (HP:0002625)3.07881515
44Metabolic alkalosis (HP:0200114)3.07578395
45Broad metatarsal (HP:0001783)3.06963350
46Abnormal urine output (HP:0012590)3.02786465
47Insulin resistance (HP:0000855)3.02033162
48Abnormality of polysaccharide metabolism (HP:0011012)3.00227244
49Abnormality of glycosaminoglycan metabolism (HP:0004371)3.00227244
50Abnormality of mucopolysaccharide metabolism (HP:0011020)3.00227244
51Esophageal varix (HP:0002040)2.97858604
52Hyperparathyroidism (HP:0000843)2.96594650
53Abnormal drinking behavior (HP:0030082)2.93404273
54Polydipsia (HP:0001959)2.93404273
55Abnormality of magnesium homeostasis (HP:0004921)2.93349579
56Vitreoretinal degeneration (HP:0000655)2.91643849
57Osteomalacia (HP:0002749)2.83223955
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.81487211
59Abnormality of purine metabolism (HP:0004352)2.79426395
60Abnormality of renal excretion (HP:0011036)2.76665331
61Tetany (HP:0001281)2.74859926
62Unilateral renal agenesis (HP:0000122)2.73551302
63Hyperaldosteronism (HP:0000859)2.70515553
64Retinal atrophy (HP:0001105)2.69979447
65Wrist flexion contracture (HP:0001239)2.69767674
66Complement deficiency (HP:0004431)2.69712410
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69693744
68Joint stiffness (HP:0001387)2.69086394
69Severe Myopia (HP:0011003)2.68408742
70Hemorrhage of the eye (HP:0011885)2.68360494
71Hyperphosphaturia (HP:0003109)2.65240102
72Hypophosphatemia (HP:0002148)2.63953986
73Stridor (HP:0010307)2.57221068
74Ependymoma (HP:0002888)2.56643062
75Glycosuria (HP:0003076)2.55785367
76Abnormality of urine glucose concentration (HP:0011016)2.55785367
77Malnutrition (HP:0004395)2.54983401
78Potter facies (HP:0002009)2.52240773
79Facial shape deformation (HP:0011334)2.52240773
80Hyperuricemia (HP:0002149)2.49395561
81Increased purine levels (HP:0004368)2.49395561
82Agitation (HP:0000713)2.47210417
83Alkalosis (HP:0001948)2.46934616
84Proximal tubulopathy (HP:0000114)2.44464563
85Focal segmental glomerulosclerosis (HP:0000097)2.42806780
86Conjugated hyperbilirubinemia (HP:0002908)2.42034189
87Prominent metopic ridge (HP:0005487)2.39626502
88Biconcave vertebral bodies (HP:0004586)2.39258569
89Xanthomatosis (HP:0000991)2.37087266
90Mitral stenosis (HP:0001718)2.36811281
91Delayed CNS myelination (HP:0002188)2.36538328
92Hypotension (HP:0002615)2.35623257
93Hyperkalemia (HP:0002153)2.35510849
94Cerebral aneurysm (HP:0004944)2.34116364
95Metaphyseal cupping (HP:0003021)2.33352871
96Exocrine pancreatic insufficiency (HP:0001738)2.32507877
97Hyperphosphatemia (HP:0002905)2.32442671
98Bronchomalacia (HP:0002780)2.31381363
99Adrenal overactivity (HP:0002717)2.29565278
100Glomerulonephritis (HP:0000099)2.28950299
101Nonimmune hydrops fetalis (HP:0001790)2.28032508
102Hypoplastic ischia (HP:0003175)2.27405689
103Round ear (HP:0100830)2.24982228
104Systemic lupus erythematosus (HP:0002725)2.24691718
105Spinal canal stenosis (HP:0003416)2.23978292
106Abnormal urine phosphate concentration (HP:0012599)2.23736313
107Renal salt wasting (HP:0000127)2.23404781
108Abdominal distention (HP:0003270)2.22946914
109Neonatal death (HP:0003811)2.21719256
110Vacuolated lymphocytes (HP:0001922)2.21349000
111Limb hypertonia (HP:0002509)2.21107830
112Abnormality of the intrinsic pathway (HP:0010989)2.18667281
113Skin nodule (HP:0200036)2.15629917
114Flat acetabular roof (HP:0003180)2.15407563
115Dysautonomia (HP:0002459)2.10445835
116Cerebral palsy (HP:0100021)2.10404138
117Hyperlipoproteinemia (HP:0010980)2.09423641
118Easy fatigability (HP:0003388)2.08045605
119Pheochromocytoma (HP:0002666)2.07691743
120Abnormality of the sella turcica (HP:0002679)2.07362077
121Abnormality of complement system (HP:0005339)2.07247907
122Hypercalciuria (HP:0002150)2.04442606
123Protuberant abdomen (HP:0001538)2.03800436
124Shallow orbits (HP:0000586)2.01321374
125Joint hemorrhage (HP:0005261)2.00866670
126Glomerulosclerosis (HP:0000096)1.99689731
127Aortic valve stenosis (HP:0001650)1.99625947
128Abnormality of the metopic suture (HP:0005556)1.98866869
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97488658
130Enlarged kidneys (HP:0000105)1.97108930
131Male infertility (HP:0003251)1.97041993
132Abnormality of alkaline phosphatase activity (HP:0004379)1.96167379
133Hypsarrhythmia (HP:0002521)1.95298543
134EEG with generalized epileptiform discharges (HP:0011198)1.94864477
135Pigmentary retinal degeneration (HP:0001146)1.94081436
136Prolonged partial thromboplastin time (HP:0003645)1.93550506
137Hepatoblastoma (HP:0002884)1.93156050
138Upper limb amyotrophy (HP:0009129)1.91665890
139Distal upper limb amyotrophy (HP:0007149)1.91665890
140Testicular atrophy (HP:0000029)1.91436983
141Hypoalphalipoproteinemia (HP:0003233)1.88978433
142Hypercortisolism (HP:0001578)1.88615004
143Abnormal enzyme/coenzyme activity (HP:0012379)1.88533980
144Thoracolumbar scoliosis (HP:0002944)1.88267487
145Skull defect (HP:0001362)1.88006654
146Irritability (HP:0000737)1.84814513
147Abnormality of the ischium (HP:0003174)1.84702633
148Epileptiform EEG discharges (HP:0011182)1.84004290
149Progressive neurologic deterioration (HP:0002344)1.79769609
150Elevated alkaline phosphatase (HP:0003155)1.79694340
151Menstrual irregularities (HP:0000858)1.79046086
152Aortic regurgitation (HP:0001659)1.78317988
153Thin bony cortex (HP:0002753)1.77508614
154Abnormality of the femoral head (HP:0003368)1.77388818
155Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77241324
156Metaphyseal irregularity (HP:0003025)1.77036133
157Hypobetalipoproteinemia (HP:0003563)1.76501019
158Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76378212
159Atelectasis (HP:0100750)1.75715050
160Neuroendocrine neoplasm (HP:0100634)1.75468554
161Hydroxyprolinuria (HP:0003080)1.73685658
162Tachypnea (HP:0002789)1.73372112
163Nephrolithiasis (HP:0000787)1.71975836
164Disproportionate short-trunk short stature (HP:0003521)1.64109452
165Abnormality of nucleobase metabolism (HP:0010932)1.64033220
166Widely patent fontanelles and sutures (HP:0004492)1.63424722
167Delayed epiphyseal ossification (HP:0002663)1.63313037
168Congenital glaucoma (HP:0001087)1.63063934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.82892402
2MAPK156.58041166
3WNK35.22861382
4PASK4.78651413
5WNK44.52347864
6KDR3.46501898
7PRKD33.26366423
8TAOK32.87135335
9MAP2K62.77869761
10HIPK22.52163098
11TNK22.45380580
12FRK2.36929258
13MUSK2.25363671
14MAP3K22.17498766
15ERN12.16689112
16NME12.11730400
17FLT32.08365288
18MAP3K62.07217253
19PIK3CG2.06154203
20PKN21.86008623
21ERBB21.80220693
22MAP3K71.77332830
23FGFR21.73289513
24NTRK11.67364308
25UHMK11.48694446
26MAP3K11.47960893
27SCYL21.46579375
28PTK21.37276420
29PDGFRA1.35432883
30DYRK1B1.33556599
31PTK61.26646948
32BMX1.26021493
33EPHA31.23267832
34BCKDK1.23175866
35WNK11.19277229
36OXSR11.18956738
37MET1.14468166
38CAMKK21.12368128
39LMTK21.11415139
40PRKD21.10975566
41FGFR31.09994187
42TRIB31.08522125
43RPS6KL11.02387620
44RPS6KC11.02387620
45PRKCH1.02364488
46IRAK30.99829688
47PAK30.98142151
48CDC42BPA0.98106872
49DDR20.96676757
50FGFR40.94375533
51MAP2K20.93673571
52IRAK10.93224996
53BRSK20.89093873
54RPS6KA60.87324935
55PRKAA20.86907886
56DAPK20.83780341
57EPHA20.79598767
58FER0.75612387
59NTRK30.71242314
60SIK10.70867964
61SIK20.69887463
62TAOK10.68680415
63PAK40.68548186
64EIF2AK30.68393037
65MAP4K10.66763890
66TBK10.64561323
67ICK0.64214577
68PRKCI0.62559231
69FGFR10.61255553
70MAPKAPK30.60561751
71PTK2B0.58605325
72MAP3K110.57241998
73MAPK80.56522984
74EEF2K0.56489971
75STK380.55840347
76PDPK10.54336467
77RIPK10.52670279
78GRK60.52311054
79EPHB10.50457398
80ROCK10.49958533
81GSK3A0.48986407
82TIE10.48249149
83BRD40.47691655
84PRKAA10.47492886
85SMG10.47286826
86SGK2230.46494901
87SGK4940.46494901
88ITK0.46091434
89MAP3K30.45749222
90JAK20.43977317
91EPHB20.43589416
92PRKCE0.41735179
93MAPK70.40850130
94STK38L0.39644701
95PHKG20.39465780
96PHKG10.39465780
97CSK0.38995616
98SRC0.38235434
99MAP2K30.38118917
100MAPK10.37294721
101IRAK20.36839352
102SIK30.36677456
103TESK10.36629397
104MTOR0.36402211
105MAPK30.34291524
106CDK90.33686405
107CAMK2D0.33005313
108BRAF0.32491923
109STK390.31437092
110RET0.31119694
111PIK3CA0.30329826
112NLK0.30193148
113IKBKE0.29938955
114ZAP700.29935000
115MATK0.29724044
116RPS6KA10.29239156
117STK160.29008439
118TYRO30.27781579
119PRKACG0.27246741
120ACVR1B0.27120303
121PRKD10.26886666
122KSR20.26106139
123JAK30.25851457
124TYK20.25795054
125AKT30.24054183
126DYRK30.23873985
127CSNK1A10.23545432
128MARK20.23120989
129IGF1R0.22588749
130MAP2K10.21554322
131CHUK0.21376431
132PRKACA0.21006023
133BRSK10.20778740
134PRKG20.20504287
135BMPR1B0.19286886
136SGK30.19213601
137SGK20.18469981
138JAK10.17717191
139SGK10.17416768
140PDGFRB0.17031639
141PRKDC0.16898000
142BCR0.16167641
143CAMK2B0.15878638
144PRKCA0.15820284
145DYRK1A0.15076873
146RPS6KA20.13558434
147CAMKK10.13388403
148MAPK140.13255145
149CDK50.12601483
150LATS10.11930053
151MST1R0.10497654
152RPS6KA30.10086759
153BTK0.10027292
154NEK60.08806171

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.60527113
2Protein export_Homo sapiens_hsa030604.63513742
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.57752545
4Sulfur metabolism_Homo sapiens_hsa009203.30107899
5Insulin secretion_Homo sapiens_hsa049113.00686743
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.89234298
7Arginine biosynthesis_Homo sapiens_hsa002202.71881033
8Notch signaling pathway_Homo sapiens_hsa043302.43988984
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.15990664
10Type II diabetes mellitus_Homo sapiens_hsa049302.09744225
11Complement and coagulation cascades_Homo sapiens_hsa046102.02406129
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99724852
13Vibrio cholerae infection_Homo sapiens_hsa051101.99435142
14Type I diabetes mellitus_Homo sapiens_hsa049401.91227914
15Selenocompound metabolism_Homo sapiens_hsa004501.86642230
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85108813
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77950492
18Retinol metabolism_Homo sapiens_hsa008301.74320775
19Butanoate metabolism_Homo sapiens_hsa006501.71360800
20Caffeine metabolism_Homo sapiens_hsa002321.58514101
21Other glycan degradation_Homo sapiens_hsa005111.58484713
22Lysosome_Homo sapiens_hsa041421.58141370
23Tryptophan metabolism_Homo sapiens_hsa003801.55723040
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48207534
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.48039568
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45745542
27N-Glycan biosynthesis_Homo sapiens_hsa005101.45050115
28Chemical carcinogenesis_Homo sapiens_hsa052041.44300108
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43499029
30Pancreatic secretion_Homo sapiens_hsa049721.43118791
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.37864087
32Folate biosynthesis_Homo sapiens_hsa007901.35512448
33Sulfur relay system_Homo sapiens_hsa041221.34337335
34PPAR signaling pathway_Homo sapiens_hsa033201.30478262
35Cocaine addiction_Homo sapiens_hsa050301.28927995
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26263459
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20020857
38Collecting duct acid secretion_Homo sapiens_hsa049661.19891370
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.19061273
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15900699
41Protein digestion and absorption_Homo sapiens_hsa049741.10964750
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.10463153
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09436351
44Thyroid hormone synthesis_Homo sapiens_hsa049181.01248600
45Regulation of autophagy_Homo sapiens_hsa041400.99138700
46ABC transporters_Homo sapiens_hsa020100.98362804
47Glucagon signaling pathway_Homo sapiens_hsa049220.97911670
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97614991
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96045575
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93492555
51Starch and sucrose metabolism_Homo sapiens_hsa005000.90974928
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90821254
53Arachidonic acid metabolism_Homo sapiens_hsa005900.89142703
54Fatty acid degradation_Homo sapiens_hsa000710.88623463
55Lysine degradation_Homo sapiens_hsa003100.87282852
56Insulin resistance_Homo sapiens_hsa049310.86059740
57Circadian rhythm_Homo sapiens_hsa047100.82906513
58Galactose metabolism_Homo sapiens_hsa000520.82828026
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81806292
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81721600
61Ether lipid metabolism_Homo sapiens_hsa005650.80838876
62Choline metabolism in cancer_Homo sapiens_hsa052310.79133638
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78936899
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78716389
65Amphetamine addiction_Homo sapiens_hsa050310.77868412
66Dorso-ventral axis formation_Homo sapiens_hsa043200.74749931
67ECM-receptor interaction_Homo sapiens_hsa045120.74374459
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73354116
69GnRH signaling pathway_Homo sapiens_hsa049120.70718456
70Taste transduction_Homo sapiens_hsa047420.70398136
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.69474012
72Tight junction_Homo sapiens_hsa045300.66365539
73Fat digestion and absorption_Homo sapiens_hsa049750.66345448
74Histidine metabolism_Homo sapiens_hsa003400.65501975
75Peroxisome_Homo sapiens_hsa041460.64176317
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63469341
77Phenylalanine metabolism_Homo sapiens_hsa003600.63281395
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62845405
79Axon guidance_Homo sapiens_hsa043600.60740353
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60710413
81Ovarian steroidogenesis_Homo sapiens_hsa049130.60451045
82Sphingolipid metabolism_Homo sapiens_hsa006000.57049905
83Prion diseases_Homo sapiens_hsa050200.56315254
84Focal adhesion_Homo sapiens_hsa045100.56089732
85Prolactin signaling pathway_Homo sapiens_hsa049170.55973175
86VEGF signaling pathway_Homo sapiens_hsa043700.55325289
87Synaptic vesicle cycle_Homo sapiens_hsa047210.54593545
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54037594
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51611238
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50114702
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.49553116
92Propanoate metabolism_Homo sapiens_hsa006400.47324707
93Bile secretion_Homo sapiens_hsa049760.45943841
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45473826
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44053735
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42290346
97Fatty acid metabolism_Homo sapiens_hsa012120.42092795
98Vitamin B6 metabolism_Homo sapiens_hsa007500.41687567
99Estrogen signaling pathway_Homo sapiens_hsa049150.41544407
100Dopaminergic synapse_Homo sapiens_hsa047280.40287776
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40057371
102Mineral absorption_Homo sapiens_hsa049780.40007331
103Pyruvate metabolism_Homo sapiens_hsa006200.39829108
104Fructose and mannose metabolism_Homo sapiens_hsa000510.38909394
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38098017
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37091184
107Insulin signaling pathway_Homo sapiens_hsa049100.37043225
108Arginine and proline metabolism_Homo sapiens_hsa003300.34902325
109Linoleic acid metabolism_Homo sapiens_hsa005910.34673919
110GABAergic synapse_Homo sapiens_hsa047270.34218850
111Bladder cancer_Homo sapiens_hsa052190.33349885
112Renin-angiotensin system_Homo sapiens_hsa046140.32995688
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32726045
114Fatty acid biosynthesis_Homo sapiens_hsa000610.31822015
115Fatty acid elongation_Homo sapiens_hsa000620.31318807
116Inositol phosphate metabolism_Homo sapiens_hsa005620.30424682
117Long-term potentiation_Homo sapiens_hsa047200.30043776
118Serotonergic synapse_Homo sapiens_hsa047260.29256617
119Cholinergic synapse_Homo sapiens_hsa047250.28129700
120Vitamin digestion and absorption_Homo sapiens_hsa049770.27720884
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27585599
122Circadian entrainment_Homo sapiens_hsa047130.26090918
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.23986099
124Gastric acid secretion_Homo sapiens_hsa049710.23597208
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23361217
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23130440
127Alcoholism_Homo sapiens_hsa050340.22657296
128AMPK signaling pathway_Homo sapiens_hsa041520.20933746
129Tyrosine metabolism_Homo sapiens_hsa003500.20453947
130Thyroid cancer_Homo sapiens_hsa052160.19242291
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17725817
132Metabolic pathways_Homo sapiens_hsa011000.16912163
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.16810412
134beta-Alanine metabolism_Homo sapiens_hsa004100.16004863
135mTOR signaling pathway_Homo sapiens_hsa041500.15606115
136Antigen processing and presentation_Homo sapiens_hsa046120.15604996
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15217515
138Glycerolipid metabolism_Homo sapiens_hsa005610.14708484
139Renin secretion_Homo sapiens_hsa049240.14660616

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