KIF13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid homeostasis (GO:0055091)4.62135093
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.09311716
3L-phenylalanine catabolic process (GO:0006559)4.09311716
4macroautophagy (GO:0016236)3.67860031
5L-phenylalanine metabolic process (GO:0006558)3.65884235
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.65884235
7alpha-linolenic acid metabolic process (GO:0036109)3.62414880
8protein carboxylation (GO:0018214)3.60431603
9peptidyl-glutamic acid carboxylation (GO:0017187)3.60431603
10urea cycle (GO:0000050)3.59312836
11urea metabolic process (GO:0019627)3.59312836
12complement activation, alternative pathway (GO:0006957)3.59229029
13protein localization to endosome (GO:0036010)3.57641661
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.38220643
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.37069739
16low-density lipoprotein particle clearance (GO:0034383)3.36850600
17aromatic amino acid family catabolic process (GO:0009074)3.35805046
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35421145
19regulation of cholesterol homeostasis (GO:2000188)3.33030272
20cholesterol efflux (GO:0033344)3.31713767
21plasma lipoprotein particle clearance (GO:0034381)3.31014242
22nitrogen cycle metabolic process (GO:0071941)3.28720252
23sulfur amino acid catabolic process (GO:0000098)3.28198270
24phospholipid efflux (GO:0033700)3.27568558
25positive regulation of p38MAPK cascade (GO:1900745)3.20630971
26negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.17515798
27regulation of protein activation cascade (GO:2000257)3.16711398
28intestinal cholesterol absorption (GO:0030299)3.15396249
29response to lipoprotein particle (GO:0055094)3.13615803
30bile acid metabolic process (GO:0008206)3.12669803
31regulation of cholesterol storage (GO:0010885)3.12258651
32bile acid biosynthetic process (GO:0006699)3.10656851
33homocysteine metabolic process (GO:0050667)3.09421572
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.04835491
35triglyceride homeostasis (GO:0070328)3.04190539
36acylglycerol homeostasis (GO:0055090)3.04190539
37regulation of complement activation (GO:0030449)3.01633416
38high-density lipoprotein particle remodeling (GO:0034375)3.01234225
39reverse cholesterol transport (GO:0043691)3.01168523
40desmosome organization (GO:0002934)3.01078477
41plasma lipoprotein particle assembly (GO:0034377)2.98949318
42regulation of triglyceride catabolic process (GO:0010896)2.97076968
43positive regulation of sterol transport (GO:0032373)2.94969044
44positive regulation of cholesterol transport (GO:0032376)2.94969044
45positive regulation of cholesterol efflux (GO:0010875)2.94535447
46regulation of cholesterol biosynthetic process (GO:0045540)2.93874612
47positive regulation of lipid catabolic process (GO:0050996)2.93334521
48apoptotic cell clearance (GO:0043277)2.92345021
49tryptophan metabolic process (GO:0006568)2.92314823
50lipoprotein metabolic process (GO:0042157)2.90513233
51protein-lipid complex assembly (GO:0065005)2.89339965
52amyloid precursor protein catabolic process (GO:0042987)2.86644806
53regulation of fatty acid beta-oxidation (GO:0031998)2.85736765
54cholesterol homeostasis (GO:0042632)2.84744713
55lipoprotein transport (GO:0042953)2.82725429
56very-low-density lipoprotein particle assembly (GO:0034379)2.82085455
57regulation of bile acid biosynthetic process (GO:0070857)2.81012965
58sterol homeostasis (GO:0055092)2.80127362
59tyrosine metabolic process (GO:0006570)2.79415833
60growth hormone receptor signaling pathway (GO:0060396)2.76488017
61positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75396179
62myelin maintenance (GO:0043217)2.73823421
63indolalkylamine catabolic process (GO:0046218)2.73302214
64tryptophan catabolic process (GO:0006569)2.73302214
65indole-containing compound catabolic process (GO:0042436)2.73302214
66negative regulation of lipid storage (GO:0010888)2.71924249
67bile acid and bile salt transport (GO:0015721)2.71538186
68negative regulation of lipase activity (GO:0060192)2.70660734
69lipid homeostasis (GO:0055088)2.69051263
70regulation of cholesterol metabolic process (GO:0090181)2.68974948
71glucocorticoid biosynthetic process (GO:0006704)2.68332348
72mannose metabolic process (GO:0006013)2.67507092
73embryonic retina morphogenesis in camera-type eye (GO:0060059)2.67331263
74regulation of sequestering of triglyceride (GO:0010889)2.65010077
75regulation of protein polyubiquitination (GO:1902914)2.63948505
76positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63641749
77valine metabolic process (GO:0006573)2.61458493
78negative regulation of fibrinolysis (GO:0051918)2.61421938
79kynurenine metabolic process (GO:0070189)2.60965365
80positive regulation of fatty acid oxidation (GO:0046321)2.60701354
81glyoxylate metabolic process (GO:0046487)2.59563720
82regulation of macrophage chemotaxis (GO:0010758)2.59364106
83regulation of fibrinolysis (GO:0051917)2.58691913
84bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58216277
85regulation of cholesterol esterification (GO:0010872)2.57898238
86import into cell (GO:0098657)2.57314356
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.56914715
88ethanol oxidation (GO:0006069)2.56371112
89protein-lipid complex remodeling (GO:0034368)2.55297787
90macromolecular complex remodeling (GO:0034367)2.55297787
91plasma lipoprotein particle remodeling (GO:0034369)2.55297787
92regulation of cholesterol transport (GO:0032374)2.54444121
93regulation of sterol transport (GO:0032371)2.54444121
94sterol transport (GO:0015918)2.51858943
95cholesterol transport (GO:0030301)2.51858943
96dicarboxylic acid biosynthetic process (GO:0043650)2.45771289
97hormone catabolic process (GO:0042447)2.44100533
98regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43117705
99plasma lipoprotein particle organization (GO:0071827)2.41885768
100detection of molecule of bacterial origin (GO:0032490)2.41747241
101barbed-end actin filament capping (GO:0051016)2.41202542
102amino-acid betaine metabolic process (GO:0006577)2.40838310
103negative regulation of cholesterol transport (GO:0032375)2.40808584
104negative regulation of sterol transport (GO:0032372)2.40808584
105positive regulation of Rap GTPase activity (GO:0032854)2.40339612
106fatty acid transmembrane transport (GO:1902001)2.40031545
107protein-lipid complex subunit organization (GO:0071825)2.39987663
108regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39621850
109regulation of transforming growth factor beta1 production (GO:0032908)2.39609759
110regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39348484
111cellular glucuronidation (GO:0052695)2.38939281
112transcytosis (GO:0045056)2.35808922
113glucocorticoid metabolic process (GO:0008211)2.35445302
114positive regulation of cellular amide metabolic process (GO:0034250)2.35164243
115regulation of ARF protein signal transduction (GO:0032012)2.34837673
116peptide catabolic process (GO:0043171)2.34555488
117intestinal absorption (GO:0050892)2.33306409
118positive regulation of lipoprotein lipase activity (GO:0051006)2.32195797
119regulation of extracellular matrix disassembly (GO:0010715)2.28792132
120cell volume homeostasis (GO:0006884)2.28593276
121multicellular organismal water homeostasis (GO:0050891)2.28439129
122negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26870318
123amyloid precursor protein metabolic process (GO:0042982)2.26270016
124interleukin-6-mediated signaling pathway (GO:0070102)2.25551198
125cellular response to ethanol (GO:0071361)2.18755433
126regulation of p38MAPK cascade (GO:1900744)2.15815512
127surfactant homeostasis (GO:0043129)2.12951579
128membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.12112304
129response to laminar fluid shear stress (GO:0034616)2.12097921
130regulation of water loss via skin (GO:0033561)2.11351496
131hypotonic response (GO:0006971)2.08098468
132sodium ion export (GO:0071436)2.07809049
133regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07474300
134fat-soluble vitamin biosynthetic process (GO:0042362)2.06543848
135establishment of endothelial barrier (GO:0061028)2.05884490
136regulation of apoptotic cell clearance (GO:2000425)2.04807297
137actin filament capping (GO:0051693)2.04803178
138negative regulation of fatty acid transport (GO:2000192)2.04727050
139glycosphingolipid catabolic process (GO:0046479)2.04478567
140adhesion of symbiont to host (GO:0044406)2.04080706
141progesterone metabolic process (GO:0042448)2.03928201
142glycosylceramide metabolic process (GO:0006677)2.02246369
143regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.01566504
144angiotensin maturation (GO:0002003)2.01464780
145positive regulation of receptor recycling (GO:0001921)2.01076021
146detection of external biotic stimulus (GO:0098581)1.99822704
147negative regulation of protein activation cascade (GO:2000258)1.99473493
148water homeostasis (GO:0030104)1.99469635
149negative regulation of erythrocyte differentiation (GO:0045647)1.98455420
150maintenance of gastrointestinal epithelium (GO:0030277)1.98227010
151negative regulation of complement activation (GO:0045916)1.97562607
152regulation of vitamin metabolic process (GO:0030656)1.95189269
153regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)1.94866687
154iron ion import (GO:0097286)1.92980247
155ovulation (GO:0030728)1.91772732
156positive regulation of steroid biosynthetic process (GO:0010893)1.91707783
157positive regulation of steroid metabolic process (GO:0045940)1.91019884
158macrophage activation involved in immune response (GO:0002281)1.90955099
159platelet-derived growth factor receptor signaling pathway (GO:0048008)1.90349458
160glucuronate metabolic process (GO:0019585)1.90347370
161uronic acid metabolic process (GO:0006063)1.90347370
162glycolipid catabolic process (GO:0019377)1.90322069
163negative regulation of humoral immune response (GO:0002921)1.90016851
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.89728012
165skin morphogenesis (GO:0043589)1.89660320
166regulation of Rap GTPase activity (GO:0032317)1.89375341
167epoxygenase P450 pathway (GO:0019373)1.89159021
168histone H3-K36 demethylation (GO:0070544)1.88475307
169antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.87257718
170cortical actin cytoskeleton organization (GO:0030866)1.87234668
171membrane repolarization during action potential (GO:0086011)1.86686032
172lipid translocation (GO:0034204)1.86431692
173phospholipid translocation (GO:0045332)1.86431692
174sodium ion homeostasis (GO:0055078)1.86070375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.80504010
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.91383429
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.79790207
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.39387807
5NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98837607
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81274044
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54901022
8GATA1_22025678_ChIP-Seq_K562_Human2.53624455
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.48128252
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.35592336
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27943784
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27094148
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12918315
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.00772339
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00644747
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94572629
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.93639123
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.80962783
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70584279
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.68996684
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68419105
22* FOXO3_23340844_ChIP-Seq_DLD1_Human1.65856053
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61788076
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.56951492
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55355408
26* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51655179
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51311104
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.50716971
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45306641
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45081762
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.41648725
32CLOCK_20551151_ChIP-Seq_293T_Human1.37034936
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36401862
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35611951
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29947352
36* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29296104
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28925924
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28549643
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28473752
40AHR_22903824_ChIP-Seq_MCF-7_Human1.28215009
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27712476
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26870737
43* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25152332
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.25108366
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24662968
46GATA1_19941826_ChIP-Seq_K562_Human1.24641141
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24372453
48VDR_24787735_ChIP-Seq_THP-1_Human1.23805709
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23473732
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22674269
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21735399
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20143976
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17798630
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16519694
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.16137668
56* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15802138
57GATA4_25053715_ChIP-Seq_YYC3_Human1.14417052
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.14132682
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13717790
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13717790
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13347741
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13236686
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12738413
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.09869937
65DROSHA_22980978_ChIP-Seq_HELA_Human1.08759432
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08181196
67RUNX_20019798_ChIP-Seq_JUKART_Human1.08105291
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07870457
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07397113
70RACK7_27058665_Chip-Seq_MCF-7_Human1.06197411
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03788673
72LXR_22292898_ChIP-Seq_THP-1_Human1.03309335
73SPI1_23127762_ChIP-Seq_K562_Human1.02678648
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02537241
75TCF7_22412390_ChIP-Seq_EML_Mouse1.02068334
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.01050228
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00365963
78CJUN_26792858_Chip-Seq_BT549_Human0.99843388
79TBX20_22328084_ChIP-Seq_HEART_Mouse0.99835823
80TBX20_22080862_ChIP-Seq_HEART_Mouse0.99835823
81GATA6_25053715_ChIP-Seq_YYC3_Human0.99556361
82GATA2_19941826_ChIP-Seq_K562_Human0.99453723
83* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99181655
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98909675
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98356183
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.97635468
87SCL_19346495_ChIP-Seq_HPC-7_Human0.97613013
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97343607
89TP53_16413492_ChIP-PET_HCT116_Human0.97026902
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96357306
91ESR1_20079471_ChIP-ChIP_T-47D_Human0.95077433
92* KLF5_25053715_ChIP-Seq_YYC3_Human0.94943967
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93068469
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93068469
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92068657
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.91917916
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91915985
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.91609150
99* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91187527
100TRIM28_21343339_ChIP-Seq_HEK293_Human0.91102090
101ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90263359
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90187442
103TP63_23658742_ChIP-Seq_EP156T_Human0.89660471
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89425772
105SOX2_20726797_ChIP-Seq_SW620_Human0.89139514
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88721976
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88692030
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88404251
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88305585
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87621805
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85845009
112RXR_22108803_ChIP-Seq_LS180_Human0.85653450
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.85094939
114KDM2B_26808549_Chip-Seq_K562_Human0.83698321
115* RUNX1_27514584_Chip-Seq_MCF-7_Human0.83556320
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83513854
117BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83249273
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.83150968
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81293013
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80700045
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79956081
122SMAD_19615063_ChIP-ChIP_OVARY_Human0.78947776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.00402364
2MP0005360_urolithiasis4.31755656
3MP0005365_abnormal_bile_salt4.27577956
4MP0005085_abnormal_gallbladder_physiolo3.84106615
5MP0000569_abnormal_digit_pigmentation3.68109595
6MP0003252_abnormal_bile_duct3.52707765
7MP0008004_abnormal_stomach_pH3.37511492
8MP0000678_abnormal_parathyroid_gland3.30085636
9MP0008438_abnormal_cutaneous_collagen2.73090308
10MP0009840_abnormal_foam_cell2.71770844
11MP0010329_abnormal_lipoprotein_level2.66311378
12MP0005409_darkened_coat_color2.53225034
13MP0008875_abnormal_xenobiotic_pharmacok2.50224892
14MP0003705_abnormal_hypodermis_morpholog2.49380786
15MP0003195_calcinosis2.42323221
16MP0003300_gastrointestinal_ulcer2.35342917
17MP0003303_peritoneal_inflammation2.35086454
18MP0005058_abnormal_lysosome_morphology2.30748799
19MP0003806_abnormal_nucleotide_metabolis2.24510339
20MP0002254_reproductive_system_inflammat2.18811041
21MP0002909_abnormal_adrenal_gland2.16801586
22MP0003283_abnormal_digestive_organ2.15840146
23MP0001666_abnormal_nutrient_absorption2.14373977
24MP0003724_increased_susceptibility_to2.11324825
25MP0003191_abnormal_cellular_cholesterol2.08133619
26MP0005083_abnormal_biliary_tract2.04576656
27MP0003172_abnormal_lysosome_physiology1.95221097
28MP0000609_abnormal_liver_physiology1.83925667
29MP0002118_abnormal_lipid_homeostasis1.81033981
30MP0005670_abnormal_white_adipose1.75354674
31MP0003690_abnormal_glial_cell1.74291260
32MP0002166_altered_tumor_susceptibility1.61104933
33MP0000465_gastrointestinal_hemorrhage1.58544522
34MP0010155_abnormal_intestine_physiology1.56926986
35MP0005275_abnormal_skin_tensile1.55122456
36MP0001765_abnormal_ion_homeostasis1.54132848
37MP0002796_impaired_skin_barrier1.50574240
38MP0005166_decreased_susceptibility_to1.44883012
39MP0002138_abnormal_hepatobiliary_system1.41296488
40MP0002877_abnormal_melanocyte_morpholog1.40875795
41MP0004130_abnormal_muscle_cell1.40520648
42MP0010234_abnormal_vibrissa_follicle1.39480618
43MP0003879_abnormal_hair_cell1.39278335
44MP0003329_amyloid_beta_deposits1.38910871
45MP0003566_abnormal_cell_adhesion1.38627894
46MP0000604_amyloidosis1.38404513
47MP0005076_abnormal_cell_differentiation1.38064327
48MP0004185_abnormal_adipocyte_glucose1.34689054
49MP0003045_fibrosis1.33799946
50MP0003866_abnormal_defecation1.31530025
51MP0005666_abnormal_adipose_tissue1.29848388
52MP0004264_abnormal_extraembryonic_tissu1.28776868
53MP0003868_abnormal_feces_composition1.26493000
54MP0000003_abnormal_adipose_tissue1.25672778
55MP0002060_abnormal_skin_morphology1.24157519
56MP0005332_abnormal_amino_acid1.23438720
57MP0009780_abnormal_chondrocyte_physiolo1.19635010
58MP0000371_diluted_coat_color1.17443255
59MP0003183_abnormal_peptide_metabolism1.16218275
60MP0005451_abnormal_body_composition1.15202020
61MP0005375_adipose_tissue_phenotype1.12653655
62MP0001661_extended_life_span1.11552555
63MP0010678_abnormal_skin_adnexa1.09769998
64MP0004019_abnormal_vitamin_homeostasis1.08275399
65MP0006082_CNS_inflammation1.07471844
66MP0009278_abnormal_bone_marrow1.06369933
67MP0005647_abnormal_sex_gland1.02805449
68MP0003453_abnormal_keratinocyte_physiol1.01085258
69MP0005408_hypopigmentation1.00274773
70MP0005319_abnormal_enzyme/_coenzyme1.00084197
71MP0002168_other_aberrant_phenotype0.97824217
72MP0000920_abnormal_myelination0.97107207
73MP0009643_abnormal_urine_homeostasis0.96564079
74MP0004510_myositis0.94390918
75MP0004947_skin_inflammation0.94307402
76MP0002006_tumorigenesis0.93949246
77MP0003436_decreased_susceptibility_to0.93744383
78MP0010307_abnormal_tumor_latency0.93709313
79MP0003091_abnormal_cell_migration0.92974856
80MP0001664_abnormal_digestion0.92696852
81MP0005164_abnormal_response_to0.91320059
82MP0005025_abnormal_response_to0.90374506
83MP0004782_abnormal_surfactant_physiolog0.90139802
84MP0009763_increased_sensitivity_to0.89843859
85MP0005165_increased_susceptibility_to0.89799876
86MP0001851_eye_inflammation0.89582145
87MP0001873_stomach_inflammation0.89270037
88MP0003656_abnormal_erythrocyte_physiolo0.88529498
89MP0002998_abnormal_bone_remodeling0.87757139
90MP0005334_abnormal_fat_pad0.87158254
91MP0002136_abnormal_kidney_physiology0.86630510
92MP0005023_abnormal_wound_healing0.85828293
93MP0002876_abnormal_thyroid_physiology0.85347501
94MP0005636_abnormal_mineral_homeostasis0.84559397
95MP0008260_abnormal_autophagy0.84138396
96MP0001845_abnormal_inflammatory_respons0.83391302
97MP0003828_pulmonary_edema0.82614361
98MP0000249_abnormal_blood_vessel0.82531298
99MP0002928_abnormal_bile_duct0.81721710
100MP0002078_abnormal_glucose_homeostasis0.81436020
101MP0005503_abnormal_tendon_morphology0.80336569
102MP0009765_abnormal_xenobiotic_induced0.79604767
103MP0000598_abnormal_liver_morphology0.79315251
104MP0002098_abnormal_vibrissa_morphology0.78365247
105MP0005584_abnormal_enzyme/coenzyme_acti0.78235756
106MP0000013_abnormal_adipose_tissue0.76963219
107MP0009785_altered_susceptibility_to0.75901382
108MP0002971_abnormal_brown_adipose0.75849724
109MP0004043_abnormal_pH_regulation0.75172910
110MP0001756_abnormal_urination0.74786724
111MP0002933_joint_inflammation0.74773916
112MP0000383_abnormal_hair_follicle0.74635223
113MP0005464_abnormal_platelet_physiology0.74054379
114MP0003950_abnormal_plasma_membrane0.73868098
115MP0005220_abnormal_exocrine_pancreas0.73769458
116MP0003075_altered_response_to0.72909582
117MP0001835_abnormal_antigen_presentation0.72787415
118MP0010368_abnormal_lymphatic_system0.72642679
119MP0001533_abnormal_skeleton_physiology0.71479337
120MP0000462_abnormal_digestive_system0.71115699
121MP0001502_abnormal_circadian_rhythm0.70872049
122MP0003633_abnormal_nervous_system0.70862848
123MP0001958_emphysema0.70706434
124MP0003632_abnormal_nervous_system0.68572408
125MP0002419_abnormal_innate_immunity0.68327890
126MP0004381_abnormal_hair_follicle0.67491042
127MP0001243_abnormal_dermal_layer0.67473809
128MP0002896_abnormal_bone_mineralization0.67430635
129MP0008469_abnormal_protein_level0.67038228
130MP0004134_abnormal_chest_morphology0.66836633
131MP0002295_abnormal_pulmonary_circulatio0.66473170
132MP0002009_preneoplasia0.66066829
133MP0001663_abnormal_digestive_system0.65680566
134MP0010352_gastrointestinal_tract_polyps0.64681887
135MP0000427_abnormal_hair_cycle0.64608160
136MP0005167_abnormal_blood-brain_barrier0.64056567
137MP0005310_abnormal_salivary_gland0.64030454
138MP0000685_abnormal_immune_system0.63097259
139MP0001790_abnormal_immune_system0.62836325
140MP0005387_immune_system_phenotype0.62836325

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.38440719
2Xanthomatosis (HP:0000991)3.92310042
3Deep venous thrombosis (HP:0002625)3.71763368
4Epidermoid cyst (HP:0200040)3.66425430
5Complement deficiency (HP:0004431)3.57263574
6Myocardial infarction (HP:0001658)3.50044964
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38396004
8Tetany (HP:0001281)3.36858628
9Prolonged partial thromboplastin time (HP:0003645)3.32723244
10Hyperphosphatemia (HP:0002905)3.30603194
11Malnutrition (HP:0004395)3.27857211
12Joint hemorrhage (HP:0005261)3.24521060
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.19322558
14Eczematoid dermatitis (HP:0000976)3.14618132
15Hyperactive renin-angiotensin system (HP:0000841)3.02229948
16Hypoplastic ischia (HP:0003175)2.97376725
17Abnormality of the common coagulation pathway (HP:0010990)2.95574575
18Abnormality of the intrinsic pathway (HP:0010989)2.94845773
19Hypoalphalipoproteinemia (HP:0003233)2.93922308
20Turricephaly (HP:0000262)2.84355374
21Abnormality of calcium-phosphate metabolism (HP:0100530)2.84163570
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82545612
23Abnormality of liposaccharide metabolism (HP:0010968)2.81195230
24Abnormality of glycosphingolipid metabolism (HP:0004343)2.81195230
25Abnormality of glycolipid metabolism (HP:0010969)2.81195230
26Abnormality of the ischium (HP:0003174)2.80370043
27Conjugated hyperbilirubinemia (HP:0002908)2.77282904
28Vacuolated lymphocytes (HP:0001922)2.76042387
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63861340
30Hyperlipoproteinemia (HP:0010980)2.62749698
31Abnormality of complement system (HP:0005339)2.57091824
32Dysostosis multiplex (HP:0000943)2.56200520
33Hypolipoproteinemia (HP:0010981)2.54063414
34Axonal loss (HP:0003447)2.54004417
35Cerebral aneurysm (HP:0004944)2.52700899
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52486630
37Hypercholesterolemia (HP:0003124)2.52252022
38Ulnar bowing (HP:0003031)2.48728441
39Fat malabsorption (HP:0002630)2.48064579
40Systemic lupus erythematosus (HP:0002725)2.45753442
41Neurofibrillary tangles (HP:0002185)2.44960198
42Abnormality of renin-angiotensin system (HP:0000847)2.44467638
43Protuberant abdomen (HP:0001538)2.42169769
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.39820481
45Skin nodule (HP:0200036)2.39217305
46Hypobetalipoproteinemia (HP:0003563)2.31503702
47Hyperaldosteronism (HP:0000859)2.29883987
48Hypoglycemic seizures (HP:0002173)2.29245645
49Abnormality of chloride homeostasis (HP:0011422)2.24373142
50Hypoglycemic coma (HP:0001325)2.23730919
51Flat acetabular roof (HP:0003180)2.22444538
52Increased circulating renin level (HP:0000848)2.20916543
53Abnormality of proline metabolism (HP:0010907)2.19811824
54Hydroxyprolinuria (HP:0003080)2.19811824
55Mucopolysacchariduria (HP:0008155)2.18964673
56Urinary glycosaminoglycan excretion (HP:0003541)2.18964673
57Increased IgE level (HP:0003212)2.18334502
58Esophageal varix (HP:0002040)2.17638967
59Thoracolumbar scoliosis (HP:0002944)2.14709241
60Alacrima (HP:0000522)2.12424078
61Hyperparathyroidism (HP:0000843)2.12302552
62Gingival bleeding (HP:0000225)2.11030095
63Autoimmune thrombocytopenia (HP:0001973)2.09974790
64Cupped ribs (HP:0000887)2.09769969
65Abnormality of macrophages (HP:0004311)2.09363975
66Ketosis (HP:0001946)2.08426047
67Increased CSF protein (HP:0002922)2.07312022
68Decreased circulating renin level (HP:0003351)2.07126333
69Abnormality of polysaccharide metabolism (HP:0011012)2.06340242
70Interstitial pulmonary disease (HP:0006530)2.06328931
71Lip pit (HP:0100267)2.06236652
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05568951
73Peripheral demyelination (HP:0011096)2.05524454
74Enlarged kidneys (HP:0000105)2.04763291
75Epiphyseal dysplasia (HP:0002656)2.04562212
76Hyporeflexia of lower limbs (HP:0002600)2.03767901
77Hyperinsulinemic hypoglycemia (HP:0000825)2.02240103
78Gingivitis (HP:0000230)2.01717609
79J-shaped sella turcica (HP:0002680)2.01618123
80Abdominal distention (HP:0003270)2.01086933
81Increased cerebral lipofuscin (HP:0011813)2.00345725
82Abnormal foot bone ossification (HP:0010675)2.00023682
83Bell-shaped thorax (HP:0001591)1.99976263
84Cerebral inclusion bodies (HP:0100314)1.98741272
85Urethral obstruction (HP:0000796)1.98692686
86Glomerulonephritis (HP:0000099)1.98164474
87Right ventricular cardiomyopathy (HP:0011663)1.97239351
88Cardiovascular calcification (HP:0011915)1.97075152
89Thin bony cortex (HP:0002753)1.96362664
90Vascular calcification (HP:0004934)1.95427286
91Renal cortical cysts (HP:0000803)1.94984063
92Elevated alkaline phosphatase (HP:0003155)1.94482234
93Abnormality of methionine metabolism (HP:0010901)1.94163845
94Amyloidosis (HP:0011034)1.93115853
95Hyperglycemia (HP:0003074)1.93056336
96Abnormal enzyme/coenzyme activity (HP:0012379)1.92483205
97Hematochezia (HP:0002573)1.92478657
98Congenital sensorineural hearing impairment (HP:0008527)1.91794264
99Increased connective tissue (HP:0009025)1.91095940
100Visceral angiomatosis (HP:0100761)1.90376991
101Metaphyseal irregularity (HP:0003025)1.89247181
102Abnormal tarsal ossification (HP:0008369)1.87105970
103Hypophosphatemia (HP:0002148)1.86689671
104Hypochromic microcytic anemia (HP:0004840)1.86608298
105Onion bulb formation (HP:0003383)1.86105131
106Abnormality of the periventricular white matter (HP:0002518)1.85665789
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85652517
108Absent frontal sinuses (HP:0002688)1.85368202
109Metaphyseal cupping (HP:0003021)1.85304276
110Scanning speech (HP:0002168)1.84864283
111Thick nail (HP:0001805)1.84355370
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84138635
113Abnormality of alkaline phosphatase activity (HP:0004379)1.83340483
114Alopecia of scalp (HP:0002293)1.83139215
115Recurrent gram-negative bacterial infections (HP:0005420)1.82948971
116Mixed hearing impairment (HP:0000410)1.82710768
117Hypoplasia of dental enamel (HP:0006297)1.82299398
118Loss of speech (HP:0002371)1.81767080
119Tubulointerstitial nephritis (HP:0001970)1.81214039
120Aneurysm (HP:0002617)1.80412567
121Metabolic alkalosis (HP:0200114)1.79880558
122Ventricular fibrillation (HP:0001663)1.79534137
123Periodontitis (HP:0000704)1.79343520
124Hyperkalemia (HP:0002153)1.78065031
125Hemorrhage of the eye (HP:0011885)1.77926800
126Abnormality of purine metabolism (HP:0004352)1.77662779
127Broad face (HP:0000283)1.76073001
128Thoracic kyphosis (HP:0002942)1.75803131
129Mitral stenosis (HP:0001718)1.75370862
130Macroorchidism (HP:0000053)1.74389040
131Nephritis (HP:0000123)1.74350843
132Tibial bowing (HP:0002982)1.74207382
133Heterotopia (HP:0002282)1.73974218
134Tetraparesis (HP:0002273)1.73467012
135Symptomatic seizures (HP:0011145)1.73415896
136Hyperglycinuria (HP:0003108)1.73405539
137Steatorrhea (HP:0002570)1.73056788
138Hepatocellular carcinoma (HP:0001402)1.72029472
139Renal salt wasting (HP:0000127)1.71046374
140Hemangiomatosis (HP:0007461)1.69697879
141Coarse hair (HP:0002208)1.68544951
142Dysmetric saccades (HP:0000641)1.65747362
143Hypocalcemia (HP:0002901)1.64752428
144Abnormality of the fingertips (HP:0001211)1.64288632
145Aplasia involving bones of the upper limbs (HP:0009823)1.64276934
146Aplasia of the phalanges of the hand (HP:0009802)1.64276934
147Aplasia involving bones of the extremities (HP:0009825)1.64276934
148Obstructive sleep apnea (HP:0002870)1.63647072
149Sensorimotor neuropathy (HP:0007141)1.63471417
150Osteolytic defects of the hand bones (HP:0009699)1.62569310
151Osteolytic defects of the phalanges of the hand (HP:0009771)1.62569310
152Bone pain (HP:0002653)1.62082045
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61844328
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61844328
155Stridor (HP:0010307)1.61222888
156Slow saccadic eye movements (HP:0000514)1.61085040
157Decreased lacrimation (HP:0000633)1.60784117
158Recurrent bacterial skin infections (HP:0005406)1.60583627
159Hypotension (HP:0002615)1.59912635
160Abnormality of the nasal mucosa (HP:0000433)1.58990586
161Adrenal overactivity (HP:0002717)1.58648398
162Abnormal glucose tolerance (HP:0001952)1.58510166
163Segmental peripheral demyelination/remyelination (HP:0003481)1.56834870
164Colitis (HP:0002583)1.56293566
165Rickets (HP:0002748)1.56109235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK12.93564630
2TAOK32.88327387
3RIPK12.81749933
4PRPF4B2.79646290
5INSRR2.79393156
6CAMK1D2.61395897
7CDK122.44579976
8FRK2.41809383
9CAMK1G2.31623638
10EPHB12.25384381
11PTK62.08455861
12FGFR42.01200869
13LATS11.97033845
14JAK11.81485649
15MAP3K141.74707592
16MET1.62297783
17TYK21.62183792
18FGFR21.61572306
19PINK11.59773252
20EPHA31.57291486
21TTN1.55804632
22TRIB31.51362697
23MAP3K11.38504287
24PDGFRB1.35003632
25FER1.33227639
26ERN11.32341713
27BLK1.28396608
28WNK11.28265421
29STK241.27871950
30PTK21.27285273
31NLK1.24413495
32FGFR31.21638609
33MAP3K31.18445949
34MAP3K21.18346354
35STK391.16465967
36PDGFRA1.15557240
37PKN11.15482100
38STK381.14974702
39CDK61.14737989
40DDR21.13767537
41MTOR1.12420218
42SGK31.10059582
43STK31.07372632
44PDK21.06738682
45ZAP701.05124898
46MAP3K101.04894898
47JAK21.04491577
48ACVR1B1.03982490
49MAP3K131.03792169
50AKT31.03759747
51LMTK20.99430601
52JAK30.98134926
53NEK60.97059136
54CHUK0.96362446
55GSK3A0.93890474
56DAPK20.93775463
57EPHA20.93537256
58IRAK30.91649275
59PRKD30.91552802
60MST1R0.88592321
61TGFBR20.87926828
62DMPK0.87166427
63RIPK40.85878797
64MAP3K70.84193582
65NUAK10.82628184
66FGR0.82442387
67PRKAA20.82033678
68ERBB40.81595914
69IRAK10.80347577
70CSF1R0.79749390
71IKBKE0.78233791
72ZAK0.77911113
73PDPK10.77175907
74CSK0.76578695
75STK40.76142358
76PRKAA10.74968672
77BRD40.74680728
78TAOK20.73837190
79PRKCH0.73745166
80MAP4K10.73630952
81MELK0.73436906
82NTRK10.73255487
83BCKDK0.72692856
84PRKD10.72279413
85ERBB20.70021627
86PIK3CA0.69401870
87TAOK10.69276897
88CDC42BPA0.66715364
89IKBKB0.66458123
90ICK0.66148778
91PKN20.66104851
92SMG10.65690572
93STK100.65476362
94MAPK120.64888676
95PDK10.64453431
96TRPM70.64054092
97BMX0.63078058
98SGK2230.62898346
99SGK4940.62898346
100MARK20.62513106
101SIK20.62166695
102PAK30.62106811
103PIK3CG0.61899071
104MST40.61855269
105HIPK20.61746693
106EEF2K0.61634904
107RET0.61384974
108SGK20.60729785
109KIT0.58923290
110MAPK150.56768540
111FLT30.55823434
112TBK10.55090301
113SGK10.53781260
114OXSR10.52619292
115NTRK30.52433335
116PTK2B0.51775490
117PRKCQ0.50725213
118MAPK70.49991969
119MAPK110.49733592
120MAP2K30.48491746
121MAP2K60.47529001
122ITK0.46940632
123NEK90.44188446
124KSR20.42929495
125PRKG20.42516202
126HCK0.42011094
127MAP2K20.41576334
128YES10.41545821
129PAK20.41454783
130BMPR20.41250444
131MATK0.40671656
132CDK90.40511711
133PRKD20.40277825
134INSR0.40054643
135TNK20.38775033

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.63668235
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.07271552
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32588469
4Complement and coagulation cascades_Homo sapiens_hsa046102.30573045
5Caffeine metabolism_Homo sapiens_hsa002322.18311318
6Arginine biosynthesis_Homo sapiens_hsa002202.15590556
7Staphylococcus aureus infection_Homo sapiens_hsa051501.99607999
8Tryptophan metabolism_Homo sapiens_hsa003801.95278493
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93640299
10Fatty acid degradation_Homo sapiens_hsa000711.92060278
11ABC transporters_Homo sapiens_hsa020101.88698041
12PPAR signaling pathway_Homo sapiens_hsa033201.88142021
13Sulfur metabolism_Homo sapiens_hsa009201.79630904
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75334045
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.68731196
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61797540
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61417859
18Histidine metabolism_Homo sapiens_hsa003401.59386255
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58487347
20Lysine degradation_Homo sapiens_hsa003101.57622947
21Bile secretion_Homo sapiens_hsa049761.42766965
22Starch and sucrose metabolism_Homo sapiens_hsa005001.41405785
23Fatty acid metabolism_Homo sapiens_hsa012121.40689790
24Type II diabetes mellitus_Homo sapiens_hsa049301.37950206
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35839599
26Peroxisome_Homo sapiens_hsa041461.27929142
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24929255
28beta-Alanine metabolism_Homo sapiens_hsa004101.24036076
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22115360
30Fat digestion and absorption_Homo sapiens_hsa049751.19586667
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19403732
32Propanoate metabolism_Homo sapiens_hsa006401.17841452
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.17572808
34Insulin resistance_Homo sapiens_hsa049311.17213820
35Butanoate metabolism_Homo sapiens_hsa006501.14838064
36Glycerolipid metabolism_Homo sapiens_hsa005611.14566594
37Selenocompound metabolism_Homo sapiens_hsa004501.14207897
38Retinol metabolism_Homo sapiens_hsa008301.08008331
39Steroid biosynthesis_Homo sapiens_hsa001001.05703601
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04520081
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02070593
42Ovarian steroidogenesis_Homo sapiens_hsa049131.01722324
43Fatty acid biosynthesis_Homo sapiens_hsa000611.01574597
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.00821358
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.00551488
46Chemical carcinogenesis_Homo sapiens_hsa052041.00331461
47Pancreatic secretion_Homo sapiens_hsa049720.95125944
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94166925
49Vitamin B6 metabolism_Homo sapiens_hsa007500.93341380
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91008481
51Vitamin digestion and absorption_Homo sapiens_hsa049770.90139202
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.88412374
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88286687
54Lysosome_Homo sapiens_hsa041420.83588091
55GnRH signaling pathway_Homo sapiens_hsa049120.81386996
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81183049
57Leishmaniasis_Homo sapiens_hsa051400.79256042
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.78993388
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77283653
60Tight junction_Homo sapiens_hsa045300.74969895
61Pertussis_Homo sapiens_hsa051330.74895719
62Renin secretion_Homo sapiens_hsa049240.74493180
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74102521
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73084994
65Gastric acid secretion_Homo sapiens_hsa049710.72797570
66Dorso-ventral axis formation_Homo sapiens_hsa043200.71847363
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71730790
68Phenylalanine metabolism_Homo sapiens_hsa003600.71171832
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70421923
70ECM-receptor interaction_Homo sapiens_hsa045120.70159677
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70060232
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69100735
73Protein digestion and absorption_Homo sapiens_hsa049740.67070145
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66927786
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.64158956
76Arachidonic acid metabolism_Homo sapiens_hsa005900.63113202
77Other glycan degradation_Homo sapiens_hsa005110.62291874
78Tuberculosis_Homo sapiens_hsa051520.60979549
79Prolactin signaling pathway_Homo sapiens_hsa049170.60874634
80Renal cell carcinoma_Homo sapiens_hsa052110.60365201
81Choline metabolism in cancer_Homo sapiens_hsa052310.60164982
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.59400532
83Ether lipid metabolism_Homo sapiens_hsa005650.59271373
84Tyrosine metabolism_Homo sapiens_hsa003500.58362152
85VEGF signaling pathway_Homo sapiens_hsa043700.57287571
86Circadian rhythm_Homo sapiens_hsa047100.56563727
87Endometrial cancer_Homo sapiens_hsa052130.55755146
88Influenza A_Homo sapiens_hsa051640.55170007
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54683037
90Fatty acid elongation_Homo sapiens_hsa000620.54615373
91Inositol phosphate metabolism_Homo sapiens_hsa005620.53996479
92Amoebiasis_Homo sapiens_hsa051460.53986685
93AMPK signaling pathway_Homo sapiens_hsa041520.53795635
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50683140
95Platelet activation_Homo sapiens_hsa046110.50439475
96Estrogen signaling pathway_Homo sapiens_hsa049150.49951980
97Acute myeloid leukemia_Homo sapiens_hsa052210.49910280
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48783816
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48494857
100Renin-angiotensin system_Homo sapiens_hsa046140.48216108
101Endocytosis_Homo sapiens_hsa041440.48169684
102Osteoclast differentiation_Homo sapiens_hsa043800.44888209
103Focal adhesion_Homo sapiens_hsa045100.42261691
104Mineral absorption_Homo sapiens_hsa049780.41949559
105Toxoplasmosis_Homo sapiens_hsa051450.41365943
106Fructose and mannose metabolism_Homo sapiens_hsa000510.40725928
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40698139
108mTOR signaling pathway_Homo sapiens_hsa041500.39974595
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38901968
110Folate biosynthesis_Homo sapiens_hsa007900.37928113
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.37441652
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.36882781
113Insulin signaling pathway_Homo sapiens_hsa049100.36157494
114Prion diseases_Homo sapiens_hsa050200.35534391
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34682495
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30372199
117Arginine and proline metabolism_Homo sapiens_hsa003300.30070906
118Malaria_Homo sapiens_hsa051440.29556452
119Proteoglycans in cancer_Homo sapiens_hsa052050.29070986
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28569262
121Chronic myeloid leukemia_Homo sapiens_hsa052200.28523375
122Sphingolipid metabolism_Homo sapiens_hsa006000.27731119
123Adherens junction_Homo sapiens_hsa045200.27662486
124Pyruvate metabolism_Homo sapiens_hsa006200.27660864
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27134931
126Glucagon signaling pathway_Homo sapiens_hsa049220.26886648
127Small cell lung cancer_Homo sapiens_hsa052220.25564193
128Hepatitis C_Homo sapiens_hsa051600.25338481
129TNF signaling pathway_Homo sapiens_hsa046680.23746734
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23608631
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23175630
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22073155
133Prostate cancer_Homo sapiens_hsa052150.21379470
134Thyroid hormone synthesis_Homo sapiens_hsa049180.21103242
135Galactose metabolism_Homo sapiens_hsa000520.20357743
136B cell receptor signaling pathway_Homo sapiens_hsa046620.20030100

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