KIF15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.79692905
2kinetochore organization (GO:0051383)5.53769419
3DNA unwinding involved in DNA replication (GO:0006268)5.28978592
4sister chromatid segregation (GO:0000819)5.20467084
5mitotic sister chromatid segregation (GO:0000070)5.16833520
6protein localization to chromosome, centromeric region (GO:0071459)5.09176482
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.05423907
8nuclear pore complex assembly (GO:0051292)5.01289898
9mitotic chromosome condensation (GO:0007076)4.91713490
10nuclear pore organization (GO:0006999)4.91267532
11mitotic metaphase plate congression (GO:0007080)4.76420450
12kinetochore assembly (GO:0051382)4.63738021
13metaphase plate congression (GO:0051310)4.48123376
14chromatin remodeling at centromere (GO:0031055)4.46876948
15DNA strand elongation involved in DNA replication (GO:0006271)4.46742539
16CENP-A containing nucleosome assembly (GO:0034080)4.46444217
17DNA replication initiation (GO:0006270)4.33815039
18mitotic sister chromatid cohesion (GO:0007064)4.30930284
19attachment of spindle microtubules to kinetochore (GO:0008608)4.28413721
20telomere maintenance via semi-conservative replication (GO:0032201)4.24899156
21DNA strand elongation (GO:0022616)4.24604857
22mitotic recombination (GO:0006312)4.19660193
23establishment of chromosome localization (GO:0051303)4.19609852
24meiotic chromosome segregation (GO:0045132)4.18998531
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.17612901
26mitotic nuclear envelope disassembly (GO:0007077)4.15220885
27regulation of spindle organization (GO:0090224)4.11120057
28DNA replication-independent nucleosome assembly (GO:0006336)4.09175085
29DNA replication-independent nucleosome organization (GO:0034724)4.09175085
30establishment of integrated proviral latency (GO:0075713)4.05873769
31DNA replication-dependent nucleosome organization (GO:0034723)4.04051604
32DNA replication-dependent nucleosome assembly (GO:0006335)4.04051604
33DNA replication checkpoint (GO:0000076)4.01079649
34telomere maintenance via recombination (GO:0000722)3.98401440
35DNA topological change (GO:0006265)3.97788848
36pore complex assembly (GO:0046931)3.94544912
37histone exchange (GO:0043486)3.86650019
38DNA geometric change (GO:0032392)3.85340460
39DNA duplex unwinding (GO:0032508)3.85025773
40membrane disassembly (GO:0030397)3.84305699
41nuclear envelope disassembly (GO:0051081)3.84305699
42centriole replication (GO:0007099)3.79499319
43regulation of DNA endoreduplication (GO:0032875)3.73395949
44chromosome segregation (GO:0007059)3.70443772
45regulation of mitotic spindle organization (GO:0060236)3.69806543
46spindle checkpoint (GO:0031577)3.69252297
47regulation of chromosome segregation (GO:0051983)3.67437844
48protein localization to chromosome (GO:0034502)3.67032437
49positive regulation of chromosome segregation (GO:0051984)3.64786500
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.62025782
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.62025782
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.62025782
53mitotic G2/M transition checkpoint (GO:0044818)3.61607784
54non-recombinational repair (GO:0000726)3.59641555
55double-strand break repair via nonhomologous end joining (GO:0006303)3.59641555
56chromatin assembly or disassembly (GO:0006333)3.57432552
57telomere maintenance via telomere lengthening (GO:0010833)3.57155890
58chromosome condensation (GO:0030261)3.56456153
59spindle assembly checkpoint (GO:0071173)3.56175636
60microtubule depolymerization (GO:0007019)3.55604579
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.55079700
62regulation of sister chromatid cohesion (GO:0007063)3.53787335
63negative regulation of chromosome segregation (GO:0051985)3.51159691
64DNA strand renaturation (GO:0000733)3.49596232
65regulation of histone H3-K9 methylation (GO:0051570)3.49528264
66regulation of centrosome cycle (GO:0046605)3.49214082
67negative regulation of mitosis (GO:0045839)3.48264662
68negative regulation of mitotic sister chromatid separation (GO:2000816)3.47909447
69negative regulation of mitotic sister chromatid segregation (GO:0033048)3.47909447
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.47909447
71negative regulation of sister chromatid segregation (GO:0033046)3.47909447
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.47395007
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47365731
74regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46124593
75DNA conformation change (GO:0071103)3.44969464
76translesion synthesis (GO:0019985)3.44501119
77DNA double-strand break processing (GO:0000729)3.44179491
78V(D)J recombination (GO:0033151)3.41598404
79regulation of centriole replication (GO:0046599)3.41130637
80microtubule polymerization or depolymerization (GO:0031109)3.40989863
81resolution of meiotic recombination intermediates (GO:0000712)3.40772132
82ATP-dependent chromatin remodeling (GO:0043044)3.38414721
83mitotic spindle assembly checkpoint (GO:0007094)3.38321751
84regulation of sister chromatid segregation (GO:0033045)3.37757949
85regulation of mitotic sister chromatid separation (GO:0010965)3.37757949
86regulation of mitotic sister chromatid segregation (GO:0033047)3.37757949
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36531374
88replication fork processing (GO:0031297)3.35406271
89mitotic spindle checkpoint (GO:0071174)3.34887676
90DNA packaging (GO:0006323)3.27692846
91spindle assembly involved in mitosis (GO:0090307)3.24708715
92negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.22924112
93IMP biosynthetic process (GO:0006188)3.22399172
94dosage compensation (GO:0007549)3.20727540
95negative regulation of cell division (GO:0051782)3.17300404
96chromosome organization (GO:0051276)3.15628478
97mitotic spindle organization (GO:0007052)3.14280498
98telomere maintenance (GO:0000723)3.13158696
99regulation of double-strand break repair via homologous recombination (GO:0010569)3.12983239
100DNA ligation (GO:0006266)3.12461173
101heterochromatin organization (GO:0070828)3.10852321
102postreplication repair (GO:0006301)3.10502820
103telomere organization (GO:0032200)3.10325500
104protein K6-linked ubiquitination (GO:0085020)3.07828701
105pre-miRNA processing (GO:0031054)3.06904820
106negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05015539
107regulation of centrosome duplication (GO:0010824)3.02054498
108negative regulation of DNA-dependent DNA replication (GO:2000104)3.01659040
109somatic diversification of immune receptors via somatic mutation (GO:0002566)3.01506914
110somatic hypermutation of immunoglobulin genes (GO:0016446)3.01506914
111mismatch repair (GO:0006298)3.00992147
112chromatin assembly (GO:0031497)2.96572052
113negative regulation of RNA splicing (GO:0033119)2.93931833
114mitotic DNA integrity checkpoint (GO:0044774)2.93614873
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.93445417
116folic acid-containing compound biosynthetic process (GO:0009396)2.93433214
117mitotic cell cycle (GO:0000278)2.93202172
118nuclear envelope organization (GO:0006998)2.92744317
119intra-S DNA damage checkpoint (GO:0031573)2.92560496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human7.05376386
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.04458332
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.24527167
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.48343514
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.90892333
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74522697
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69843419
8AR_21909140_ChIP-Seq_LNCAP_Human2.60815325
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54732595
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.50966700
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41590092
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40999242
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20848260
14* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19716613
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18435233
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12032223
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08573073
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08375621
19* EST1_17652178_ChIP-ChIP_JURKAT_Human2.06667099
20E2F7_22180533_ChIP-Seq_HELA_Human11.5717933
21XRN2_22483619_ChIP-Seq_HELA_Human1.97209770
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86640546
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84502404
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80672749
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79331584
26VDR_23849224_ChIP-Seq_CD4+_Human1.74287425
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71858623
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.70526243
29MYC_22102868_ChIP-Seq_BL_Human1.69951916
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.69632016
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.67585113
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.60525822
33TTF2_22483619_ChIP-Seq_HELA_Human1.59746094
34* CIITA_25753668_ChIP-Seq_RAJI_Human1.59723044
35ELK1_19687146_ChIP-ChIP_HELA_Human1.59382146
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.58746742
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56916487
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56112454
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54418198
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49307993
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48178969
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46842871
43* DCP1A_22483619_ChIP-Seq_HELA_Human1.44757625
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43669644
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42556877
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42309370
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39837781
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35888365
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34789887
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34659391
51KDM5A_27292631_Chip-Seq_BREAST_Human1.32873373
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30340438
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27789501
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27612142
55GABP_19822575_ChIP-Seq_HepG2_Human1.26883540
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25196682
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24350571
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23111662
59EWS_26573619_Chip-Seq_HEK293_Human1.21217826
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20354285
61* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18794390
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18159099
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14337492
64VDR_21846776_ChIP-Seq_THP-1_Human1.11482345
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09000423
66* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08075937
67* NANOG_16153702_ChIP-ChIP_HESCs_Human1.07604131
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05747132
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05089849
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04141977
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01728308
72FUS_26573619_Chip-Seq_HEK293_Human1.00991065
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97742933
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94336694
75MYC_18940864_ChIP-ChIP_HL60_Human0.92729492
76TFEB_21752829_ChIP-Seq_HELA_Human0.92549955
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89621454
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89319832
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89135371
80IRF1_19129219_ChIP-ChIP_H3396_Human0.88271274
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87563905
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87325535
83YY1_21170310_ChIP-Seq_MESCs_Mouse0.87227033
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87144366
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.87124655
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.86217837
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86170902
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85153411
89* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84354401
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82192303
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82044574
92SPI1_23547873_ChIP-Seq_NB4_Human0.82000423
93* SRF_21415370_ChIP-Seq_HL-1_Mouse0.81809137
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80364149
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78183552
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76791308
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75895139
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73559526
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73348938
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72486628
101MYB_26560356_Chip-Seq_TH1_Human0.72439368
102* SOX2_16153702_ChIP-ChIP_HESCs_Human0.72346611
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71303877
104SOX9_26525672_Chip-Seq_HEART_Mouse0.70723974
105MYB_26560356_Chip-Seq_TH2_Human0.70360502
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.70236034
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.70032272
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69496362
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.68796348
110PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68007467
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.67885128
112ZNF274_21170338_ChIP-Seq_K562_Hela0.65282996
113GATA1_26923725_Chip-Seq_HPCs_Mouse0.61828276
114NOTCH1_21737748_ChIP-Seq_TLL_Human0.60943485
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.60477431
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.56966888
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.56250676
118CHD1_26751641_Chip-Seq_LNCaP_Human0.56012655
119IGF1R_20145208_ChIP-Seq_DFB_Human0.55270623
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.53337937
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.51391039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.90407272
2MP0003693_abnormal_embryo_hatching4.76346331
3MP0003111_abnormal_nucleus_morphology4.51685178
4MP0008057_abnormal_DNA_replication4.24688053
5MP0003077_abnormal_cell_cycle3.95668508
6MP0004957_abnormal_blastocyst_morpholog3.76148625
7MP0008058_abnormal_DNA_repair2.97649187
8MP0008007_abnormal_cellular_replicative2.64020543
9MP0010307_abnormal_tumor_latency2.44303775
10MP0008932_abnormal_embryonic_tissue2.43629713
11MP0002396_abnormal_hematopoietic_system2.37497650
12MP0010352_gastrointestinal_tract_polyps2.25281714
13MP0003123_paternal_imprinting2.24595077
14MP0008877_abnormal_DNA_methylation2.21822767
15MP0000350_abnormal_cell_proliferation2.17893875
16MP0001730_embryonic_growth_arrest2.16231359
17MP0009697_abnormal_copulation2.15755516
18MP0005076_abnormal_cell_differentiation1.89948907
19MP0003121_genomic_imprinting1.87501177
20MP0005380_embryogenesis_phenotype1.80963244
21MP0001672_abnormal_embryogenesis/_devel1.80963244
22MP0003136_yellow_coat_color1.78555123
23MP0004808_abnormal_hematopoietic_stem1.75803287
24MP0000569_abnormal_digit_pigmentation1.74566140
25MP0001697_abnormal_embryo_size1.69433495
26MP0000490_abnormal_crypts_of1.64230431
27MP0003984_embryonic_growth_retardation1.61435316
28MP0002085_abnormal_embryonic_tissue1.59349654
29MP0002088_abnormal_embryonic_growth/wei1.58157059
30MP0004197_abnormal_fetal_growth/weight/1.57272285
31MP0002084_abnormal_developmental_patter1.56384096
32MP0009053_abnormal_anal_canal1.48968774
33MP0002086_abnormal_extraembryonic_tissu1.48537715
34MP0003786_premature_aging1.48411781
35MP0003890_abnormal_embryonic-extraembry1.47847006
36MP0002080_prenatal_lethality1.47431961
37MP0000313_abnormal_cell_death1.38062350
38MP0001293_anophthalmia1.35828730
39MP0003567_abnormal_fetal_cardiomyocyte1.33468003
40MP0002019_abnormal_tumor_incidence1.32854356
41MP0000537_abnormal_urethra_morphology1.30768485
42MP0010030_abnormal_orbit_morphology1.30608392
43MP0002233_abnormal_nose_morphology1.25983415
44MP0001346_abnormal_lacrimal_gland1.24729797
45MP0008789_abnormal_olfactory_epithelium1.24118869
46MP0006054_spinal_hemorrhage1.23673051
47MP0000703_abnormal_thymus_morphology1.22642658
48MP0005171_absent_coat_pigmentation1.22302398
49MP0003787_abnormal_imprinting1.10807340
50MP0002210_abnormal_sex_determination1.08083559
51MP0003937_abnormal_limbs/digits/tail_de1.06183695
52MP0002398_abnormal_bone_marrow1.05185663
53MP0001545_abnormal_hematopoietic_system1.04744605
54MP0005397_hematopoietic_system_phenotyp1.04744605
55MP0009278_abnormal_bone_marrow1.03920430
56MP0005174_abnormal_tail_pigmentation1.03239091
57MP0003705_abnormal_hypodermis_morpholog1.00901974
58MP0003861_abnormal_nervous_system1.00856002
59MP0003763_abnormal_thymus_physiology1.00537070
60MP0006072_abnormal_retinal_apoptosis0.99422229
61MP0002234_abnormal_pharynx_morphology0.98900088
62MP0003755_abnormal_palate_morphology0.96625366
63MP0003315_abnormal_perineum_morphology0.96476940
64MP0001145_abnormal_male_reproductive0.96123089
65MP0003941_abnormal_skin_development0.95441846
66MP0001529_abnormal_vocalization0.95257977
67MP0000566_synostosis0.95159651
68MP0009703_decreased_birth_body0.94775893
69MP0009672_abnormal_birth_weight0.94647130
70MP0005394_taste/olfaction_phenotype0.94423261
71MP0005499_abnormal_olfactory_system0.94423261
72MP0002722_abnormal_immune_system0.94016417
73MP0001929_abnormal_gametogenesis0.92269946
74MP0000049_abnormal_middle_ear0.90075271
75MP0002095_abnormal_skin_pigmentation0.87983313
76MP0001915_intracranial_hemorrhage0.85952862
77MP0002111_abnormal_tail_morphology0.85519439
78MP0005391_vision/eye_phenotype0.83266043
79MP0002092_abnormal_eye_morphology0.82994597
80MP0003385_abnormal_body_wall0.82089274
81MP0000689_abnormal_spleen_morphology0.81892724
82MP0000428_abnormal_craniofacial_morphol0.81876693
83MP0003698_abnormal_male_reproductive0.81248416
84MP0001286_abnormal_eye_development0.80845381
85MP0002160_abnormal_reproductive_system0.80001471
86MP0003119_abnormal_digestive_system0.79383737
87MP0000383_abnormal_hair_follicle0.79199866
88MP0002102_abnormal_ear_morphology0.79012075
89MP0002697_abnormal_eye_size0.78743939
90MP0002751_abnormal_autonomic_nervous0.78698879
91MP0005395_other_phenotype0.78615425
92MP0000653_abnormal_sex_gland0.78246940
93MP0003115_abnormal_respiratory_system0.77252669
94MP0003935_abnormal_craniofacial_develop0.77190873
95MP0002938_white_spotting0.76878187
96MP0000432_abnormal_head_morphology0.76510887
97MP0002429_abnormal_blood_cell0.74343906
98MP0006035_abnormal_mitochondrial_morpho0.74154060
99MP0004264_abnormal_extraembryonic_tissu0.72733262
100MP0002006_tumorigenesis0.72187069
101MP0001119_abnormal_female_reproductive0.71762603
102MP0009333_abnormal_splenocyte_physiolog0.71613658
103MP0000358_abnormal_cell_content/0.70947159
104MP0000733_abnormal_muscle_development0.70089301
105MP0002166_altered_tumor_susceptibility0.69848074
106MP0000647_abnormal_sebaceous_gland0.69809143
107MP0002161_abnormal_fertility/fecundity0.69742426
108MP0003699_abnormal_female_reproductive0.69183327
109MP0000858_altered_metastatic_potential0.68861335
110MP0004147_increased_porphyrin_level0.68718275
111MP0005384_cellular_phenotype0.68655211
112MP0003566_abnormal_cell_adhesion0.68339342
113MP0005621_abnormal_cell_physiology0.68172407
114MP0002925_abnormal_cardiovascular_devel0.67801108
115MP0002075_abnormal_coat/hair_pigmentati0.67024030
116MP0000015_abnormal_ear_pigmentation0.66963428
117MP0005023_abnormal_wound_healing0.64812917
118MP0000716_abnormal_immune_system0.64156776
119MP0005248_abnormal_Harderian_gland0.64048561
120MP0000372_irregular_coat_pigmentation0.63728311
121MP0006292_abnormal_olfactory_placode0.63095649
122MP0003938_abnormal_ear_development0.62558793
123MP0000631_abnormal_neuroendocrine_gland0.62553949
124MP0001299_abnormal_eye_distance/0.62071231
125MP0002081_perinatal_lethality0.60719195
126MP0000477_abnormal_intestine_morphology0.60614677
127MP0003718_maternal_effect0.60352942
128MP0000371_diluted_coat_color0.60333066
129MP0002282_abnormal_trachea_morphology0.60295293
130MP0002932_abnormal_joint_morphology0.59928513
131MP0002009_preneoplasia0.58343353
132MP0003448_altered_tumor_morphology0.58072964
133MP0008995_early_reproductive_senescence0.57595153
134MP0002116_abnormal_craniofacial_bone0.56060701
135MP0000778_abnormal_nervous_system0.55188299
136MP0003943_abnormal_hepatobiliary_system0.54995338

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.04418329
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.77983794
3Abnormality of chromosome stability (HP:0003220)3.86388926
4Reticulocytopenia (HP:0001896)3.67384385
5Volvulus (HP:0002580)3.51059516
6Cortical dysplasia (HP:0002539)3.49020716
7Meckel diverticulum (HP:0002245)3.39780314
8Ectopic kidney (HP:0000086)3.32281355
9Medulloblastoma (HP:0002885)3.29554958
10Abnormality of the preputium (HP:0100587)3.26432237
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.26425162
12Abnormality of the ileum (HP:0001549)3.24916628
13Increased nuchal translucency (HP:0010880)3.23411946
14Colon cancer (HP:0003003)3.07101699
15Small intestinal stenosis (HP:0012848)3.06194801
16Duodenal stenosis (HP:0100867)3.06194801
17Short 4th metacarpal (HP:0010044)2.94807274
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94807274
19Ependymoma (HP:0002888)2.94713665
20Impulsivity (HP:0100710)2.93900690
21Birth length less than 3rd percentile (HP:0003561)2.92417210
22Myelodysplasia (HP:0002863)2.91241916
23Selective tooth agenesis (HP:0001592)2.86298493
24Patellar aplasia (HP:0006443)2.79675023
25Duplicated collecting system (HP:0000081)2.60933795
26Abnormality of the carotid arteries (HP:0005344)2.60665870
27Abnormal number of incisors (HP:0011064)2.58311700
28Agnosia (HP:0010524)2.58107173
29Aplasia/Hypoplasia of the patella (HP:0006498)2.58065203
30Proximal placement of thumb (HP:0009623)2.56897182
31Absent radius (HP:0003974)2.53163422
32Abnormality of the duodenum (HP:0002246)2.53059169
33Sloping forehead (HP:0000340)2.52137725
34Nephroblastoma (Wilms tumor) (HP:0002667)2.51209107
35Rhabdomyosarcoma (HP:0002859)2.50636358
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49899127
37Deviation of the thumb (HP:0009603)2.49715222
38Absent thumb (HP:0009777)2.48371473
39Embryonal neoplasm (HP:0002898)2.47321423
40Abnormal lung lobation (HP:0002101)2.41379738
41Abnormality of the labia minora (HP:0012880)2.40873235
42Aplasia involving forearm bones (HP:0009822)2.35537575
43Absent forearm bone (HP:0003953)2.35537575
4411 pairs of ribs (HP:0000878)2.34571349
45Embryonal renal neoplasm (HP:0011794)2.32697539
46Abnormality of the renal collecting system (HP:0004742)2.32217441
47Cafe-au-lait spot (HP:0000957)2.28073258
48High pitched voice (HP:0001620)2.27267213
49Bone marrow hypocellularity (HP:0005528)2.26699689
50Hypoplastic pelvis (HP:0008839)2.26176789
51Prominent nose (HP:0000448)2.22911982
52Clubbing of toes (HP:0100760)2.21774810
53Short thumb (HP:0009778)2.20905266
54Oral leukoplakia (HP:0002745)2.20309225
55Breast hypoplasia (HP:0003187)2.18933543
56High anterior hairline (HP:0009890)2.18750418
57Long eyelashes (HP:0000527)2.16825664
58Tracheoesophageal fistula (HP:0002575)2.14544547
59Deep philtrum (HP:0002002)2.13081910
60Choanal atresia (HP:0000453)2.12269684
61Renal duplication (HP:0000075)2.11972281
62Abnormality of the astrocytes (HP:0100707)2.11269431
63Astrocytoma (HP:0009592)2.11269431
64Triphalangeal thumb (HP:0001199)2.08761691
65Abnormality of DNA repair (HP:0003254)2.08529424
66Neoplasm of the oral cavity (HP:0100649)2.07358514
67Abnormality of the fingertips (HP:0001211)2.07064483
68Degeneration of anterior horn cells (HP:0002398)2.06573099
69Abnormality of the anterior horn cell (HP:0006802)2.06573099
70Basal cell carcinoma (HP:0002671)2.06310408
71Oligodactyly (hands) (HP:0001180)2.04404391
72Atresia of the external auditory canal (HP:0000413)2.03190177
73Septo-optic dysplasia (HP:0100842)2.02326642
74Glioma (HP:0009733)2.01946931
75Neoplasm of striated muscle (HP:0009728)2.00544885
76Short middle phalanx of the 5th finger (HP:0004220)1.99678112
77Facial hemangioma (HP:0000329)1.97787366
78Neoplasm of the pancreas (HP:0002894)1.97685849
79Carpal bone hypoplasia (HP:0001498)1.97645861
80Premature graying of hair (HP:0002216)1.94861925
81Abnormality of the 4th metacarpal (HP:0010012)1.93380273
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.92247743
83Overlapping toe (HP:0001845)1.91643139
84Aplastic anemia (HP:0001915)1.89856801
85Amaurosis fugax (HP:0100576)1.88797710
86Pancreatic islet-cell hyperplasia (HP:0004510)1.88569882
87Irregular epiphyses (HP:0010582)1.87962730
88Abnormality of cells of the erythroid lineage (HP:0012130)1.87956314
89Abnormality of the septum pellucidum (HP:0007375)1.86106674
90Duplication of thumb phalanx (HP:0009942)1.85790705
91Supernumerary spleens (HP:0009799)1.85122912
92Horseshoe kidney (HP:0000085)1.81324718
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81267729
94Arteriovenous malformation (HP:0100026)1.80746732
95Missing ribs (HP:0000921)1.80482656
96Long clavicles (HP:0000890)1.80428314
97Abnormality of cochlea (HP:0000375)1.80301787
98Neoplasm of the colon (HP:0100273)1.80211614
99Intestinal atresia (HP:0011100)1.80042108
100Biliary tract neoplasm (HP:0100574)1.79846482
101Gastrointestinal carcinoma (HP:0002672)1.79472933
102Malignant gastrointestinal tract tumors (HP:0006749)1.79472933
103Skull defect (HP:0001362)1.78588366
104Abnormal number of erythroid precursors (HP:0012131)1.78343512
105Squamous cell carcinoma (HP:0002860)1.77685956
106Absent septum pellucidum (HP:0001331)1.77523747
107Oligodactyly (HP:0012165)1.76427960
108Multiple enchondromatosis (HP:0005701)1.75842720
109Pallor (HP:0000980)1.74657294
110Cutis marmorata (HP:0000965)1.73532747
111Lymphoma (HP:0002665)1.72898503
112Absent epiphyses (HP:0010577)1.72605220
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72605220
114Holoprosencephaly (HP:0001360)1.71148714
115Abnormality of chromosome segregation (HP:0002916)1.69965001
116Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69895680
117Abdominal situs inversus (HP:0003363)1.69826810
118Abnormality of abdominal situs (HP:0011620)1.69826810
119Sandal gap (HP:0001852)1.69070027
120Acute myeloid leukemia (HP:0004808)1.68988842
121Esophageal atresia (HP:0002032)1.68918285
122Ovarian neoplasm (HP:0100615)1.67433666
123Mesomelia (HP:0003027)1.67115300
124Neoplasm of the adrenal cortex (HP:0100641)1.66687160
125Small hand (HP:0200055)1.66371285
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66057093
127Hemivertebrae (HP:0002937)1.62398156
128Small epiphyses (HP:0010585)1.60017263
129Gastrointestinal atresia (HP:0002589)1.55510705
130Facial asymmetry (HP:0000324)1.54542399
131Morphological abnormality of the inner ear (HP:0011390)1.53506468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.06565512
2BUB13.99754508
3WEE13.90580590
4NEK23.57766864
5CDK123.08910945
6TTK2.72727011
7EIF2AK12.57079580
8SRPK12.56470957
9BRSK22.29408741
10TLK12.27478462
11NEK12.26693779
12VRK22.20086610
13PLK12.16932081
14ATR2.09111130
15AURKB2.04477934
16TAF11.96215727
17MKNK11.93226519
18PLK31.85010573
19PLK41.81944706
20STK41.80250585
21PASK1.77096572
22EEF2K1.76544609
23CDK71.69345757
24CHEK21.69017483
25CDK41.60840755
26ACVR1B1.59450530
27BRSK11.58132607
28STK101.57882094
29CCNB11.56906732
30ZAK1.56450607
31BRD41.55308095
32MAP3K101.55165148
33RPS6KB21.55011199
34VRK11.50585311
35CHEK11.49738086
36TSSK61.41682926
37MAP3K81.41652621
38MKNK21.33654455
39RPS6KA41.30546626
40CDK61.28450223
41ATM1.24531880
42TNIK1.18268042
43DYRK31.09994135
44MELK1.09783139
45AURKA1.08594608
46STK31.01251232
47CDK21.00156929
48SCYL20.99316439
49PIM10.95590893
50WNK30.95532558
51TRIM280.93894446
52CLK10.92663222
53TGFBR10.91483715
54PAK40.90562628
55CDK10.87423594
56TESK20.86823790
57BRAF0.83240348
58EIF2AK20.77589633
59STK38L0.76792612
60PLK20.76618677
61MST40.73786559
62MAP4K10.71714735
63ALK0.71660727
64BMPR1B0.70179921
65SMG10.69703746
66PKN20.68607037
67EIF2AK30.65467091
68LATS20.60312412
69MTOR0.58291931
70EPHA20.57340973
71PNCK0.54079976
72CSNK2A20.53182600
73RPS6KA50.52305371
74YES10.51968783
75PRKDC0.51746092
76CDK90.51054083
77CSNK2A10.50552796
78NME20.49916287
79FLT30.49570501
80PBK0.49051467
81BCR0.46746390
82CDK30.45644853
83BTK0.45451907
84NLK0.44886583
85LATS10.44523889
86MAPK140.44009889
87AKT20.43101588
88CDK180.41169708
89CSNK1D0.40965336
90CDK150.40805502
91NME10.40796882
92MARK30.40569514
93CDK11A0.38988845
94LRRK20.38716768
95TEC0.38375934
96PAK10.38195815
97AKT10.37748170
98FGFR10.36987168
99STK160.36393950
100TTN0.35111206
101ERBB30.34540148
102NUAK10.34113664
103CDK140.34078960
104CDK80.32933227
105DYRK20.31108877
106ERBB40.30723167
107CHUK0.29288957
108CSNK1G10.28343797
109KSR10.27976704
110CAMK1G0.27690808
111ERBB20.27528735
112CSNK1E0.27230775
113CAMK1D0.26852136
114GSK3B0.26850462
115RPS6KB10.26790689
116TESK10.26777005
117MAPK10.26604820
118CSF1R0.24745615
119RPS6KL10.24546280
120RPS6KC10.24546280
121GRK60.23485598
122MAP3K40.21902722
123MAP2K30.21873288
124MAPKAPK20.21596717
125UHMK10.20896452
126PTK60.20724288
127STK390.19303342
128PRKCI0.16705274
129PKN10.16427327
130EPHB20.16154043

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04716170
2Mismatch repair_Homo sapiens_hsa034304.37237312
3Cell cycle_Homo sapiens_hsa041103.37293314
4Homologous recombination_Homo sapiens_hsa034403.36474280
5Spliceosome_Homo sapiens_hsa030403.24654958
6Base excision repair_Homo sapiens_hsa034103.18819998
7Fanconi anemia pathway_Homo sapiens_hsa034603.01041762
8RNA transport_Homo sapiens_hsa030132.94198821
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93179784
10Nucleotide excision repair_Homo sapiens_hsa034202.70517513
11One carbon pool by folate_Homo sapiens_hsa006702.63447449
12Non-homologous end-joining_Homo sapiens_hsa034502.60624253
13Systemic lupus erythematosus_Homo sapiens_hsa053222.29895850
14Ribosome_Homo sapiens_hsa030102.24469146
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14330591
16mRNA surveillance pathway_Homo sapiens_hsa030152.09473193
17RNA degradation_Homo sapiens_hsa030181.88452600
18p53 signaling pathway_Homo sapiens_hsa041151.87264372
19Pyrimidine metabolism_Homo sapiens_hsa002401.82659383
20RNA polymerase_Homo sapiens_hsa030201.82454502
21Basal transcription factors_Homo sapiens_hsa030221.58568406
22Proteasome_Homo sapiens_hsa030501.46410247
23Viral carcinogenesis_Homo sapiens_hsa052031.42835272
24Protein export_Homo sapiens_hsa030601.35979359
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30964117
26Oocyte meiosis_Homo sapiens_hsa041141.25141599
27MicroRNAs in cancer_Homo sapiens_hsa052061.20390107
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19753564
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19678136
30Herpes simplex infection_Homo sapiens_hsa051681.19205822
31Epstein-Barr virus infection_Homo sapiens_hsa051691.16829936
32HTLV-I infection_Homo sapiens_hsa051661.08463191
33Pyruvate metabolism_Homo sapiens_hsa006201.06747303
34Antigen processing and presentation_Homo sapiens_hsa046121.05802901
35Steroid biosynthesis_Homo sapiens_hsa001001.03455793
36Alcoholism_Homo sapiens_hsa050341.01790131
37Small cell lung cancer_Homo sapiens_hsa052221.01359530
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98963360
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96820027
40Propanoate metabolism_Homo sapiens_hsa006400.94615935
41Purine metabolism_Homo sapiens_hsa002300.89138245
42Basal cell carcinoma_Homo sapiens_hsa052170.88865014
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87813824
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85782827
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82411517
46Primary immunodeficiency_Homo sapiens_hsa053400.81373223
47Carbon metabolism_Homo sapiens_hsa012000.76069543
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75520852
49Chronic myeloid leukemia_Homo sapiens_hsa052200.75457970
50Lysine degradation_Homo sapiens_hsa003100.74461679
51Notch signaling pathway_Homo sapiens_hsa043300.74177122
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74139200
53Colorectal cancer_Homo sapiens_hsa052100.72634575
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70731031
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70716933
56Folate biosynthesis_Homo sapiens_hsa007900.67288490
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.67160172
58Hepatitis B_Homo sapiens_hsa051610.66874301
59Huntingtons disease_Homo sapiens_hsa050160.65405573
60Measles_Homo sapiens_hsa051620.64610767
61Apoptosis_Homo sapiens_hsa042100.62168112
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62105577
63Hippo signaling pathway_Homo sapiens_hsa043900.61524159
64Selenocompound metabolism_Homo sapiens_hsa004500.61078544
65Legionellosis_Homo sapiens_hsa051340.60938459
66Glutathione metabolism_Homo sapiens_hsa004800.60536828
67Viral myocarditis_Homo sapiens_hsa054160.59211156
68Thyroid cancer_Homo sapiens_hsa052160.57564571
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57189853
70Adherens junction_Homo sapiens_hsa045200.53651966
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53511774
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52975918
73TGF-beta signaling pathway_Homo sapiens_hsa043500.52086868
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50473784
75Parkinsons disease_Homo sapiens_hsa050120.50056496
76Prostate cancer_Homo sapiens_hsa052150.49569380
77Hedgehog signaling pathway_Homo sapiens_hsa043400.49040316
78Influenza A_Homo sapiens_hsa051640.48914580
79Pathways in cancer_Homo sapiens_hsa052000.48123692
80Non-small cell lung cancer_Homo sapiens_hsa052230.47811641
81Vitamin B6 metabolism_Homo sapiens_hsa007500.46179991
82Fatty acid elongation_Homo sapiens_hsa000620.46019465
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44519542
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44401948
85Hematopoietic cell lineage_Homo sapiens_hsa046400.44358822
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44273986
87Pentose phosphate pathway_Homo sapiens_hsa000300.43814948
88Pancreatic cancer_Homo sapiens_hsa052120.42535041
89Shigellosis_Homo sapiens_hsa051310.41491677
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.40977372
91B cell receptor signaling pathway_Homo sapiens_hsa046620.38455785
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38001792
93N-Glycan biosynthesis_Homo sapiens_hsa005100.37450967
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36699178
95Bladder cancer_Homo sapiens_hsa052190.36652724
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35692713
97Leishmaniasis_Homo sapiens_hsa051400.34952869
98Wnt signaling pathway_Homo sapiens_hsa043100.34864913
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.33959193
100Proteoglycans in cancer_Homo sapiens_hsa052050.33902840
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32976145
102FoxO signaling pathway_Homo sapiens_hsa040680.32560813
103mTOR signaling pathway_Homo sapiens_hsa041500.32314633
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.32205800
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.30831088
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30597886
107T cell receptor signaling pathway_Homo sapiens_hsa046600.30578329
108Renin-angiotensin system_Homo sapiens_hsa046140.30558759
109Biosynthesis of amino acids_Homo sapiens_hsa012300.29413593
110Asthma_Homo sapiens_hsa053100.28357695
111HIF-1 signaling pathway_Homo sapiens_hsa040660.28227794
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28000343
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26747235
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26688479
115Oxidative phosphorylation_Homo sapiens_hsa001900.26046936
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26014283
117Metabolic pathways_Homo sapiens_hsa011000.25960754
118Endometrial cancer_Homo sapiens_hsa052130.25304702
119Acute myeloid leukemia_Homo sapiens_hsa052210.25222958
120Fatty acid metabolism_Homo sapiens_hsa012120.25196034
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24176082
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.23909714
123Melanoma_Homo sapiens_hsa052180.22979409
124Toxoplasmosis_Homo sapiens_hsa051450.22347206
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.20400429
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.19310278
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18604457
128Butanoate metabolism_Homo sapiens_hsa006500.18191014
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18179856
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17191419
131Phototransduction_Homo sapiens_hsa047440.14038006
132Sulfur relay system_Homo sapiens_hsa041220.11015877
133Tight junction_Homo sapiens_hsa045300.10880552
134Melanogenesis_Homo sapiens_hsa049160.07309378
135Fatty acid degradation_Homo sapiens_hsa000710.07053534
136Alzheimers disease_Homo sapiens_hsa050100.05605371

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »