KIF16B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.41132843
2phospholipid efflux (GO:0033700)4.57216870
3plasma lipoprotein particle assembly (GO:0034377)4.32901776
4carnitine shuttle (GO:0006853)4.25356936
5very-low-density lipoprotein particle assembly (GO:0034379)4.24827184
6regulation of cholesterol esterification (GO:0010872)4.03837366
7protein-lipid complex assembly (GO:0065005)4.03273906
8fatty acid transmembrane transport (GO:1902001)4.00661109
9sarcomere organization (GO:0045214)3.98445759
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.88571402
11COPII vesicle coating (GO:0048208)3.81840793
12auditory receptor cell differentiation (GO:0042491)3.72982611
13plasma membrane repair (GO:0001778)3.72204669
14carnitine transmembrane transport (GO:1902603)3.69066632
15intestinal absorption (GO:0050892)3.68439840
16valine metabolic process (GO:0006573)3.66356682
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62642497
18amino-acid betaine transport (GO:0015838)3.61266571
19carnitine transport (GO:0015879)3.61266571
20negative regulation of keratinocyte proliferation (GO:0010839)3.54563492
21cardiac myofibril assembly (GO:0055003)3.48761962
22bundle of His cell to Purkinje myocyte communication (GO:0086069)3.45293954
23regulation of skeletal muscle contraction (GO:0014819)3.44710736
24regulation of cholesterol homeostasis (GO:2000188)3.44485405
25myofibril assembly (GO:0030239)3.39084404
26cellular glucuronidation (GO:0052695)3.28990694
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28562542
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28562542
29actin-myosin filament sliding (GO:0033275)3.24569015
30muscle filament sliding (GO:0030049)3.24569015
31intracellular lipid transport (GO:0032365)3.22877815
32regulation of sequestering of triglyceride (GO:0010889)3.21445371
33high-density lipoprotein particle remodeling (GO:0034375)3.21138045
34glucuronate metabolic process (GO:0019585)3.17044740
35uronic acid metabolic process (GO:0006063)3.17044740
36gap junction assembly (GO:0016264)3.16441215
37growth hormone receptor signaling pathway (GO:0060396)3.16380438
38regulation of bile acid biosynthetic process (GO:0070857)3.15366736
39flavonoid metabolic process (GO:0009812)3.14266219
40skeletal muscle adaptation (GO:0043501)3.12548974
412-oxoglutarate metabolic process (GO:0006103)3.11012100
42regulation of water loss via skin (GO:0033561)3.10623336
43establishment of protein localization to Golgi (GO:0072600)3.08894134
44transcytosis (GO:0045056)3.04226255
45cardiac muscle cell development (GO:0055013)3.03033938
46antigen processing and presentation of endogenous antigen (GO:0019883)3.02775037
47cholesterol efflux (GO:0033344)3.00838737
48genitalia morphogenesis (GO:0035112)2.98389361
49* early endosome to late endosome transport (GO:0045022)2.98022090
50regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.97907321
51negative regulation of potassium ion transmembrane transport (GO:1901380)2.97855480
52regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.96657788
53establishment of skin barrier (GO:0061436)2.96159306
54tricarboxylic acid cycle (GO:0006099)2.94460127
55reverse cholesterol transport (GO:0043691)2.94015159
56positive regulation of glycoprotein biosynthetic process (GO:0010560)2.93825733
57striated muscle atrophy (GO:0014891)2.92324218
58protein targeting to Golgi (GO:0000042)2.92112445
59lipoprotein metabolic process (GO:0042157)2.91666197
60retrograde transport, vesicle recycling within Golgi (GO:0000301)2.90561295
61lipoprotein transport (GO:0042953)2.87928100
62negative regulation of protein activation cascade (GO:2000258)2.87751622
63quaternary ammonium group transport (GO:0015697)2.87369802
64short-chain fatty acid metabolic process (GO:0046459)2.86230244
65cardiac cell development (GO:0055006)2.85320698
66monoubiquitinated protein deubiquitination (GO:0035520)2.83769533
67hemidesmosome assembly (GO:0031581)2.82087558
68fructose metabolic process (GO:0006000)2.81642655
69angiotensin maturation (GO:0002003)2.81564896
70regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79859397
71actin-mediated cell contraction (GO:0070252)2.79460540
72tricarboxylic acid metabolic process (GO:0072350)2.79112446
73antigen processing and presentation via MHC class Ib (GO:0002475)2.76233225
74fatty acid beta-oxidation (GO:0006635)2.76084079
75prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.75801166
76embryonic retina morphogenesis in camera-type eye (GO:0060059)2.75421364
77plasma lipoprotein particle organization (GO:0071827)2.75380527
78pinocytosis (GO:0006907)2.73941453
79epoxygenase P450 pathway (GO:0019373)2.73075167
80multicellular organismal water homeostasis (GO:0050891)2.71707572
81plasma lipoprotein particle remodeling (GO:0034369)2.71094411
82protein-lipid complex remodeling (GO:0034368)2.71094411
83macromolecular complex remodeling (GO:0034367)2.71094411
84regulation of transforming growth factor beta1 production (GO:0032908)2.69681852
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69655390
86keratinocyte development (GO:0003334)2.69556145
87protein-lipid complex subunit organization (GO:0071825)2.68766613
88actomyosin structure organization (GO:0031032)2.68556148
89bile acid metabolic process (GO:0008206)2.68037915
90positive regulation of glycoprotein metabolic process (GO:1903020)2.66638879
91regulation of interferon-beta biosynthetic process (GO:0045357)2.65448496
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.65311385
93cellular response to growth hormone stimulus (GO:0071378)2.62855553
94anterior/posterior axis specification, embryo (GO:0008595)2.59132185
95sequestering of extracellular ligand from receptor (GO:0035581)2.58983566
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.56713507
97pyrimidine ribonucleoside catabolic process (GO:0046133)2.56530861
98biotin metabolic process (GO:0006768)2.55405146
99O-glycan processing (GO:0016266)2.52768770
100creatine metabolic process (GO:0006600)2.52191748
101epithelial cell-cell adhesion (GO:0090136)2.51669774
102heme transport (GO:0015886)2.49977010
103NLS-bearing protein import into nucleus (GO:0006607)2.49120570
104intestinal epithelial cell development (GO:0060576)2.49078441
105actin filament-based movement (GO:0030048)2.48607119
106branching involved in prostate gland morphogenesis (GO:0060442)2.47927474
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.47830933
108NADH metabolic process (GO:0006734)2.47450221
109oligosaccharide catabolic process (GO:0009313)2.47035459
110cellular response to ethanol (GO:0071361)2.46408005
111triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.44087387
112regulation of keratinocyte differentiation (GO:0045616)2.43460848
113tight junction assembly (GO:0070830)2.43266638
114hair cell differentiation (GO:0035315)2.43068868
115chemical homeostasis within a tissue (GO:0048875)2.41857899
116oxaloacetate metabolic process (GO:0006107)2.41827702
117apoptotic cell clearance (GO:0043277)2.41758573
118negative regulation of complement activation (GO:0045916)2.41669412
119negative regulation of sodium ion transport (GO:0010766)2.41512771
120nuclear pore complex assembly (GO:0051292)2.41500286
121phospholipid homeostasis (GO:0055091)2.41363019
122protein localization to Golgi apparatus (GO:0034067)2.41362814
123phenylpropanoid metabolic process (GO:0009698)2.41056310
124ethanol metabolic process (GO:0006067)2.41047618
125drug transmembrane transport (GO:0006855)2.39388692
126positive regulation of keratinocyte differentiation (GO:0045618)2.38539594
127sperm capacitation (GO:0048240)2.38211321
128regulation of cholesterol storage (GO:0010885)2.37456551
129regulation of fatty acid oxidation (GO:0046320)2.36995677
130water homeostasis (GO:0030104)2.36600752
131positive regulation of gamma-delta T cell activation (GO:0046645)2.36490449
132branched-chain amino acid metabolic process (GO:0009081)2.35991084
133fibroblast migration (GO:0010761)2.35088178
134natural killer cell mediated immunity (GO:0002228)2.35073289
135natural killer cell mediated cytotoxicity (GO:0042267)2.35073289
136positive regulation of B cell differentiation (GO:0045579)2.34606439
137cholesterol homeostasis (GO:0042632)2.34366444
138fatty acid oxidation (GO:0019395)2.34085273
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.33466371
140L-phenylalanine metabolic process (GO:0006558)2.33466371
141negative regulation of lipase activity (GO:0060192)2.33334052
142ventricular cardiac muscle cell action potential (GO:0086005)2.33290754
143cytoplasmic mRNA processing body assembly (GO:0033962)2.32775453
144regulation of protein activation cascade (GO:2000257)2.32575986
145cardiac muscle hypertrophy (GO:0003300)2.32468429
146peroxisome fission (GO:0016559)2.32386894
147primary alcohol catabolic process (GO:0034310)2.31716037
148ethanol oxidation (GO:0006069)2.31653479
149lysine metabolic process (GO:0006553)2.31407760
150lysine catabolic process (GO:0006554)2.31407760
151sterol homeostasis (GO:0055092)2.31112833
1524-hydroxyproline metabolic process (GO:0019471)2.31112202
153positive regulation of p38MAPK cascade (GO:1900745)2.31094814
154cellular polysaccharide catabolic process (GO:0044247)2.30753572
155pore complex assembly (GO:0046931)2.29507192
156negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.28958706
157negative regulation of cell cycle G2/M phase transition (GO:1902750)2.28713223
158COPI coating of Golgi vesicle (GO:0048205)2.28116151
159Golgi transport vesicle coating (GO:0048200)2.28116151
160positive regulation of natural killer cell differentiation (GO:0032825)2.26982803
161lipid oxidation (GO:0034440)2.26678803
162positive regulation of histone deacetylation (GO:0031065)2.25491794
163cardiac muscle contraction (GO:0060048)2.25291812
164cellular response to osmotic stress (GO:0071470)2.25238068
165cardiolipin metabolic process (GO:0032048)2.24703621
166regulation of spindle organization (GO:0090224)2.24150276
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.23693098
168histone-serine phosphorylation (GO:0035404)2.23386686
169positive regulation of protein import into nucleus, translocation (GO:0033160)2.22851000
170vascular endothelial growth factor signaling pathway (GO:0038084)2.22560401
171regulation of mitotic spindle organization (GO:0060236)2.21576105
172regulation of gamma-delta T cell differentiation (GO:0045586)2.21295898
173striated muscle adaptation (GO:0014888)2.21152469
174positive regulation of lipid storage (GO:0010884)2.20988795
175fatty acid catabolic process (GO:0009062)2.20730781
176striated muscle hypertrophy (GO:0014897)2.19628008
177macroautophagy (GO:0016236)2.19588243
178negative regulation of lipid storage (GO:0010888)2.19126818
179regulation of acyl-CoA biosynthetic process (GO:0050812)2.18503371
180cytidine deamination (GO:0009972)2.17931765
181cytidine metabolic process (GO:0046087)2.17931765
182cytidine catabolic process (GO:0006216)2.17931765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.42629317
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.04040269
3* ZNF217_24962896_ChIP-Seq_MCF-7_Human3.02535262
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88757683
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.84920780
6CDX2_20551321_ChIP-Seq_CACO-2_Human2.78777177
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.75139935
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.49974925
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.46291872
10TCF4_18268006_ChIP-ChIP_LS174T_Human2.30831224
11ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.29267676
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23044567
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.22248498
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17945687
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.10587771
16AHR_22903824_ChIP-Seq_MCF-7_Human2.09900513
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.09065973
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07154386
19FOXM1_26456572_ChIP-Seq_MCF-7_Human2.02058070
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01967779
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01064612
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99668896
23ZNF263_19887448_ChIP-Seq_K562_Human1.95669542
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94217429
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93016218
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91241814
27GATA1_22025678_ChIP-Seq_K562_Human1.88623653
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.86520032
29* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.82440456
30AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.79841836
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.78746484
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77075454
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76498772
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.76166224
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.76099798
36SOX2_20726797_ChIP-Seq_SW620_Human1.75727967
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.73202529
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73092308
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72179355
40AR_21909140_ChIP-Seq_LNCAP_Human1.71001133
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70990749
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.70339036
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.69051493
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.69051493
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67401113
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.66194428
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65338114
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.65116402
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.63878049
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.60946107
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.59387142
52* CDX2_22108803_ChIP-Seq_LS180_Human1.57815692
53CLOCK_20551151_ChIP-Seq_293T_Human1.56151197
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55601693
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55569043
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54542008
57FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.53274101
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53067028
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52610002
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.50836894
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49736299
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.49377991
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47302195
64TP63_23658742_ChIP-Seq_EP156T_Human1.45304665
65GATA6_25053715_ChIP-Seq_YYC3_Human1.45270857
66* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44063353
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41105952
68MYC_22102868_ChIP-Seq_BL_Human1.41053065
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.40900165
70TCF7_22412390_ChIP-Seq_EML_Mouse1.40022416
71CJUN_26792858_Chip-Seq_BT549_Human1.40007461
72* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37088179
73NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35944360
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35648507
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35642853
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35642853
77MYB_26560356_Chip-Seq_TH1_Human1.34107188
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33045492
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32189474
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30711183
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30228225
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29424699
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28999018
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28525991
85MYB_26560356_Chip-Seq_TH2_Human1.28082726
86MAF_26560356_Chip-Seq_TH1_Human1.27097439
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.26519199
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26077856
89ATF3_27146783_Chip-Seq_COLON_Human1.25995550
90SCL_19346495_ChIP-Seq_HPC-7_Human1.25923503
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25838478
92GATA4_25053715_ChIP-Seq_YYC3_Human1.25075087
93SPI1_23127762_ChIP-Seq_K562_Human1.24631328
94* EP300_21415370_ChIP-Seq_HL-1_Mouse1.23905342
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23796818
96* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22888530
97TP53_16413492_ChIP-PET_HCT116_Human1.22180702
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.20461129
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19181299
100GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18183338
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17055858
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15997977
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15757824
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15145780
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15145780
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15019516
107* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14116082
108BCAT_22108803_ChIP-Seq_LS180_Human1.13395739
109E2F1_21310950_ChIP-Seq_MCF-7_Human1.12985480
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12742403
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.12456085
112* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11377247
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.10671003
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10595281
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.09790056
116SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08538585
117* ER_23166858_ChIP-Seq_MCF-7_Human1.08488094
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08412886
119UTX_26944678_Chip-Seq_JUKART_Human1.08370404
120* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08018852
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.06945081
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.06739856
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06279828
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05244792
125GATA3_27048872_Chip-Seq_THYMUS_Human1.04950682
126VDR_21846776_ChIP-Seq_THP-1_Human1.04155296
127TCF4_22108803_ChIP-Seq_LS180_Human1.03656556
128SPI1_23547873_ChIP-Seq_NB4_Human1.03591900
129* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03396127
130SMAD3_21741376_ChIP-Seq_HESCs_Human1.03329229
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03309181
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.02376991
133P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02280459
134RUNX1_27514584_Chip-Seq_MCF-7_Human1.02278490
135SMAD4_21799915_ChIP-Seq_A2780_Human1.01230423
136TFEB_21752829_ChIP-Seq_HELA_Human1.00746705
137* E2F1_18555785_Chip-Seq_ESCs_Mouse0.98554272
138* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97827452
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97194162
140PU_27001747_Chip-Seq_BMDM_Mouse0.97168199
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96888080
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96275542
143KLF5_25053715_ChIP-Seq_YYC3_Human0.95964697
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95744480
145RUNX_20019798_ChIP-Seq_JUKART_Human0.94057135
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94031242
147KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93853840
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.93732250
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93446782
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92471525
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.92318463
152NCOR1_26117541_ChIP-Seq_K562_Human0.91906894
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91733369
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91651449
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91494079
156* OCT4_18555785_Chip-Seq_ESCs_Mouse0.91421581
157* ZFX_18555785_Chip-Seq_ESCs_Mouse0.91172712
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89925762
159* SOX2_18555785_Chip-Seq_ESCs_Mouse0.89303172
160BRD4_25478319_ChIP-Seq_HGPS_Human0.89079403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue2.82481221
2MP0004084_abnormal_cardiac_muscle2.71919091
3MP0002837_dystrophic_cardiac_calcinosis2.60849579
4MP0003705_abnormal_hypodermis_morpholog2.52311419
5MP0005409_darkened_coat_color2.51006926
6MP0002796_impaired_skin_barrier2.45192747
7MP0000383_abnormal_hair_follicle2.32858632
8MP0003941_abnormal_skin_development2.29095614
9MP0009780_abnormal_chondrocyte_physiolo2.18732970
10MP0003300_gastrointestinal_ulcer2.17369127
11MP0004019_abnormal_vitamin_homeostasis2.05601019
12MP0000751_myopathy2.03286076
13MP0010329_abnormal_lipoprotein_level2.01973693
14MP0003566_abnormal_cell_adhesion1.97296719
15MP0004036_abnormal_muscle_relaxation1.95972101
16MP0002877_abnormal_melanocyte_morpholog1.95166031
17MP0004130_abnormal_muscle_cell1.87289492
18MP0005330_cardiomyopathy1.81028956
19MP0004087_abnormal_muscle_fiber1.79576664
20MP0000569_abnormal_digit_pigmentation1.75728700
21MP0010630_abnormal_cardiac_muscle1.72239680
22MP0000749_muscle_degeneration1.71756096
23MP0002166_altered_tumor_susceptibility1.65630791
24MP0000427_abnormal_hair_cycle1.62406787
25MP0003868_abnormal_feces_composition1.61210068
26MP0002098_abnormal_vibrissa_morphology1.60682185
27MP0002396_abnormal_hematopoietic_system1.56239536
28MP0005666_abnormal_adipose_tissue1.55445160
29MP0004215_abnormal_myocardial_fiber1.53428221
30MP0008438_abnormal_cutaneous_collagen1.52264386
31MP0004185_abnormal_adipocyte_glucose1.51757449
32MP0002269_muscular_atrophy1.50289268
33MP0010352_gastrointestinal_tract_polyps1.50134486
34MP0000372_irregular_coat_pigmentation1.49879534
35MP0005058_abnormal_lysosome_morphology1.48433369
36MP0000750_abnormal_muscle_regeneration1.44040297
37MP0005410_abnormal_fertilization1.42847738
38MP0003195_calcinosis1.42739457
39MP0003183_abnormal_peptide_metabolism1.36666788
40MP0003828_pulmonary_edema1.34569084
41MP0004264_abnormal_extraembryonic_tissu1.33747156
42MP0001544_abnormal_cardiovascular_syste1.32396239
43MP0005385_cardiovascular_system_phenoty1.32396239
44MP0001835_abnormal_antigen_presentation1.31440308
45MP0004272_abnormal_basement_membrane1.30414107
46MP0002106_abnormal_muscle_physiology1.30359984
47MP0004043_abnormal_pH_regulation1.30034724
48MP0000627_abnormal_mammary_gland1.28651292
49MP0003045_fibrosis1.28525911
50MP0004510_myositis1.27475648
51MP0000015_abnormal_ear_pigmentation1.25801093
52MP0004381_abnormal_hair_follicle1.25363282
53MP0010234_abnormal_vibrissa_follicle1.24465119
54MP0010307_abnormal_tumor_latency1.24381345
55MP0005275_abnormal_skin_tensile1.23806185
56MP0003221_abnormal_cardiomyocyte_apopto1.21752244
57MP0001666_abnormal_nutrient_absorption1.21153188
58MP0002118_abnormal_lipid_homeostasis1.19474914
59MP0002972_abnormal_cardiac_muscle1.19375199
60MP0000377_abnormal_hair_follicle1.19356743
61MP0000747_muscle_weakness1.19289279
62MP0001756_abnormal_urination1.17883024
63MP0005174_abnormal_tail_pigmentation1.17736419
64MP0000579_abnormal_nail_morphology1.17646178
65MP0005501_abnormal_skin_physiology1.15594078
66MP0002139_abnormal_hepatobiliary_system1.15378217
67MP0004808_abnormal_hematopoietic_stem1.14846431
68MP0005076_abnormal_cell_differentiation1.13946484
69MP0001765_abnormal_ion_homeostasis1.13226206
70MP0000467_abnormal_esophagus_morphology1.11689998
71MP0008775_abnormal_heart_ventricle1.11431019
72MP0005636_abnormal_mineral_homeostasis1.10658688
73MP0009278_abnormal_bone_marrow1.09748895
74MP0000462_abnormal_digestive_system1.09595340
75MP0005075_abnormal_melanosome_morpholog1.09256450
76MP0000371_diluted_coat_color1.08797432
77MP0009840_abnormal_foam_cell1.08577127
78MP0005451_abnormal_body_composition1.08343569
79MP0001216_abnormal_epidermal_layer1.08059841
80MP0000733_abnormal_muscle_development1.07730171
81MP0003567_abnormal_fetal_cardiomyocyte1.05744351
82MP0005332_abnormal_amino_acid1.05683799
83MP0003453_abnormal_keratinocyte_physiol1.05433983
84MP0010368_abnormal_lymphatic_system1.05284404
85MP0002006_tumorigenesis1.04215399
86MP0005365_abnormal_bile_salt1.04066393
87MP0006138_congestive_heart_failure1.03980606
88MP0003252_abnormal_bile_duct1.03448451
89MP0005620_abnormal_muscle_contractility1.03341954
90MP0004782_abnormal_surfactant_physiolog1.02943336
91MP0002138_abnormal_hepatobiliary_system1.02033542
92MP0001873_stomach_inflammation1.01242215
93MP0005670_abnormal_white_adipose1.01058122
94MP0005369_muscle_phenotype1.00770088
95MP0005375_adipose_tissue_phenotype1.00674395
96MP0004947_skin_inflammation1.00365268
97MP0005408_hypopigmentation0.99713446
98MP0000759_abnormal_skeletal_muscle0.99367852
99MP0006054_spinal_hemorrhage0.98959168
100MP0005397_hematopoietic_system_phenotyp0.97486914
101MP0001545_abnormal_hematopoietic_system0.97486914
102MP0002060_abnormal_skin_morphology0.95856387
103MP0002896_abnormal_bone_mineralization0.95770374
104MP0003191_abnormal_cellular_cholesterol0.95657226
105MP0001881_abnormal_mammary_gland0.95224285
106MP0003806_abnormal_nucleotide_metabolis0.92790485
107MP0009643_abnormal_urine_homeostasis0.91194207
108MP0000538_abnormal_urinary_bladder0.89852649
109MP0001853_heart_inflammation0.89399193
110MP0003890_abnormal_embryonic-extraembry0.88617911
111MP0004147_increased_porphyrin_level0.88266208
112MP0000609_abnormal_liver_physiology0.87518068
113MP0009115_abnormal_fat_cell0.87417940
114MP0004484_altered_response_of0.83901299
115MP0000647_abnormal_sebaceous_gland0.81374836
116MP0002090_abnormal_vision0.81231514
117MP0005023_abnormal_wound_healing0.80184718
118MP0000003_abnormal_adipose_tissue0.80184370
119MP0005310_abnormal_salivary_gland0.80148500
120MP0001958_emphysema0.80106973
121MP0005379_endocrine/exocrine_gland_phen0.79516630
122MP0000685_abnormal_immune_system0.79254718
123MP0000266_abnormal_heart_morphology0.79250597
124MP0001664_abnormal_digestion0.78473151
125MP0005319_abnormal_enzyme/_coenzyme0.78188151
126MP0002938_white_spotting0.77465436
127MP0001849_ear_inflammation0.77373847
128MP0008260_abnormal_autophagy0.77320817
129MP0005248_abnormal_Harderian_gland0.76122739
130MP0010155_abnormal_intestine_physiology0.75889603
131MP0005085_abnormal_gallbladder_physiolo0.75014449
132MP0002088_abnormal_embryonic_growth/wei0.74944906
133MP0000477_abnormal_intestine_morphology0.74606702
134MP0003984_embryonic_growth_retardation0.74516889
135MP0003279_aneurysm0.74216447
136MP0005464_abnormal_platelet_physiology0.73091633
137MP0002971_abnormal_brown_adipose0.72988946
138MP0008004_abnormal_stomach_pH0.72812458
139MP0002009_preneoplasia0.72573088
140MP0002128_abnormal_blood_circulation0.71997454
141MP0003950_abnormal_plasma_membrane0.71794646
142MP0002108_abnormal_muscle_morphology0.70671144
143MP0003091_abnormal_cell_migration0.69883815
144MP0002136_abnormal_kidney_physiology0.69641386
145MP0002332_abnormal_exercise_endurance0.69471117
146MP0000343_altered_response_to0.68422775
147MP0001879_abnormal_lymphatic_vessel0.67663395
148MP0005083_abnormal_biliary_tract0.67562449
149MP0010771_integument_phenotype0.67428218
150MP0010678_abnormal_skin_adnexa0.67341308
151MP0000767_abnormal_smooth_muscle0.66751577
152MP0005360_urolithiasis0.66671671
153MP0002254_reproductive_system_inflammat0.66500735
154MP0002127_abnormal_cardiovascular_syste0.65797507
155MP0000367_abnormal_coat/_hair0.64918542
156MP0003172_abnormal_lysosome_physiology0.64701859
157MP0008875_abnormal_xenobiotic_pharmacok0.63899720
158MP0005165_increased_susceptibility_to0.63204910
159MP0000537_abnormal_urethra_morphology0.62636598

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)4.30113545
2Increased connective tissue (HP:0009025)4.25126873
3Hyporeflexia of lower limbs (HP:0002600)4.22100571
4Ventricular tachycardia (HP:0004756)4.02984249
5Exercise-induced muscle cramps (HP:0003710)3.99467094
6Intrahepatic cholestasis (HP:0001406)3.93110296
7Right ventricular cardiomyopathy (HP:0011663)3.88402918
8Exercise-induced myalgia (HP:0003738)3.71418018
9Sudden death (HP:0001699)3.65148968
10Asymmetric septal hypertrophy (HP:0001670)3.53832781
11Myoglobinuria (HP:0002913)3.53148064
12Hypolipoproteinemia (HP:0010981)3.46656966
13Spontaneous abortion (HP:0005268)3.37752774
14Hypobetalipoproteinemia (HP:0003563)3.27999843
15Hyperkalemia (HP:0002153)3.18518808
16Hyperactive renin-angiotensin system (HP:0000841)3.15716545
17Malnutrition (HP:0004395)3.13666672
18Difficulty running (HP:0009046)3.09404713
19Subaortic stenosis (HP:0001682)3.09113767
20Abnormality of the left ventricular outflow tract (HP:0011103)3.09113767
21Lip pit (HP:0100267)3.04966126
22Fat malabsorption (HP:0002630)3.04276765
23Rhabdomyolysis (HP:0003201)3.03323458
24Lipoatrophy (HP:0100578)3.03057201
25Alopecia of scalp (HP:0002293)3.00338408
26Bundle branch block (HP:0011710)2.94840109
27Flat acetabular roof (HP:0003180)2.85897901
28Calf muscle hypertrophy (HP:0008981)2.84736420
29Septate vagina (HP:0001153)2.84492224
30Abnormality of the nasal septum (HP:0000419)2.82713541
31Abnormal pancreas size (HP:0012094)2.75966537
32Difficulty climbing stairs (HP:0003551)2.75736464
33Distal lower limb muscle weakness (HP:0009053)2.72954830
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72774808
35Conjugated hyperbilirubinemia (HP:0002908)2.71657520
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.70257463
37Hematochezia (HP:0002573)2.65291093
38Atrial fibrillation (HP:0005110)2.62839142
39Abnormality of nail color (HP:0100643)2.59695851
40Type 1 muscle fiber predominance (HP:0003803)2.57414070
41Muscle hypertrophy of the lower extremities (HP:0008968)2.55899658
42Myocardial infarction (HP:0001658)2.54637499
43Dilated cardiomyopathy (HP:0001644)2.53486035
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51990513
45Vascular calcification (HP:0004934)2.51911622
46Hypoglycemic coma (HP:0001325)2.51074864
47Osteolytic defects of the hand bones (HP:0009699)2.50177964
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.50177964
49Popliteal pterygium (HP:0009756)2.49084686
50Glomerulonephritis (HP:0000099)2.47524979
51Decreased circulating renin level (HP:0003351)2.47503431
52Subcapsular cataract (HP:0000523)2.46381362
53Nephritis (HP:0000123)2.46239247
54Hypoplastic ischia (HP:0003175)2.42760815
55Abnormality of chloride homeostasis (HP:0011422)2.42684222
56Ankle contracture (HP:0006466)2.39351194
57Cerebral palsy (HP:0100021)2.37771150
58Abnormality of the calf musculature (HP:0001430)2.37280962
59Hyperglycemia (HP:0003074)2.36989595
60Frequent falls (HP:0002359)2.36891681
61Syncope (HP:0001279)2.36134007
62Muscle fiber inclusion bodies (HP:0100299)2.34931324
63Abnormality of the fingertips (HP:0001211)2.32907703
64Facial diplegia (HP:0001349)2.31142245
65Palpitations (HP:0001962)2.31008122
66EMG: myopathic abnormalities (HP:0003458)2.28168828
67Primary atrial arrhythmia (HP:0001692)2.27119332
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25984965
69Abnormality of the ischium (HP:0003174)2.24769217
70Ketoacidosis (HP:0001993)2.21827224
71Tubulointerstitial nephritis (HP:0001970)2.21224976
72Insulin-resistant diabetes mellitus (HP:0000831)2.21099752
73Proximal tubulopathy (HP:0000114)2.18497575
74Cardiovascular calcification (HP:0011915)2.16852331
75Atrioventricular block (HP:0001678)2.16830820
76Ventricular arrhythmia (HP:0004308)2.16476050
77Biliary tract neoplasm (HP:0100574)2.15185559
78Cerebral aneurysm (HP:0004944)2.15178671
79Distal arthrogryposis (HP:0005684)2.13821106
80Palmoplantar hyperkeratosis (HP:0000972)2.13180564
81Hyperphosphatemia (HP:0002905)2.12521398
82Supraventricular tachycardia (HP:0004755)2.12496336
83Supraventricular arrhythmia (HP:0005115)2.10482609
84Abnormality of fatty-acid metabolism (HP:0004359)2.10475961
85Abnormality of complement system (HP:0005339)2.10464301
86Cone-rod dystrophy (HP:0000548)2.10277048
87Abnormal cartilage morphology (HP:0002763)2.09818237
88Abnormal biliary tract morphology (HP:0012440)2.09635475
89Anal stenosis (HP:0002025)2.09567695
90Areflexia of lower limbs (HP:0002522)2.08403115
91Pili torti (HP:0003777)2.07840191
92Focal segmental glomerulosclerosis (HP:0000097)2.07304469
93Abnormal atrioventricular conduction (HP:0005150)2.07194090
94Curly hair (HP:0002212)2.06457319
95Abnormality of vitamin B metabolism (HP:0004340)2.05595681
96Rectal prolapse (HP:0002035)2.05533391
97Symptomatic seizures (HP:0011145)2.05478694
98Abnormality of potassium homeostasis (HP:0011042)2.04102339
99Aortic aneurysm (HP:0004942)2.03954882
100Steatorrhea (HP:0002570)2.03854783
101Ketosis (HP:0001946)2.03489290
102Plantar hyperkeratosis (HP:0007556)2.03068715
103Heart block (HP:0012722)2.02396402
104Amelogenesis imperfecta (HP:0000705)2.01437905
105Hyperglycinuria (HP:0003108)2.01141695
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00851321
107Abnormality of vitamin metabolism (HP:0100508)1.98551150
108Abnormality of the vitamin B12 metabolism (HP:0004341)1.98543001
109EMG: neuropathic changes (HP:0003445)1.97564765
110Hypoplasia of dental enamel (HP:0006297)1.97553035
111Ankyloglossia (HP:0010296)1.97057581
112Palmar hyperkeratosis (HP:0010765)1.96664838
113Aneurysm (HP:0002617)1.96349678
114Glomerulosclerosis (HP:0000096)1.91903803
115Ulnar deviation of the wrist (HP:0003049)1.90918920
116Complement deficiency (HP:0004431)1.90600487
117Tetraparesis (HP:0002273)1.89956023
118Abnormality of renin-angiotensin system (HP:0000847)1.88882513
119Autoimmune thrombocytopenia (HP:0001973)1.88870670
120Myopathic facies (HP:0002058)1.87148877
121Acanthocytosis (HP:0001927)1.85638713
122Epidermoid cyst (HP:0200040)1.84861384
123Abnormality of the nasal mucosa (HP:0000433)1.84610751
124Hypoplastic labia majora (HP:0000059)1.84281297
125Hypoalphalipoproteinemia (HP:0003233)1.84022026
126Thin bony cortex (HP:0002753)1.83586925
127Abnormality of the parathyroid morphology (HP:0011766)1.83237172
128Villous atrophy (HP:0011473)1.82789030
129Abnormality of small intestinal villus morphology (HP:0011472)1.82789030
130Scapular winging (HP:0003691)1.82496972
131Abnormality of carpal bone ossification (HP:0006257)1.81698477
132Long toe (HP:0010511)1.80560533
133Hyperaldosteronism (HP:0000859)1.80385122
134Gout (HP:0001997)1.79849297
135Hypoglycemic seizures (HP:0002173)1.78404699
136Pigmentary retinal degeneration (HP:0001146)1.78221140
137Nasal polyposis (HP:0100582)1.77198161
138Germ cell neoplasia (HP:0100728)1.77047819
139Enlarged epiphyses (HP:0010580)1.77009770
140Limb-girdle muscle atrophy (HP:0003797)1.76616213
141Abnormality of the common coagulation pathway (HP:0010990)1.76374835
142Renal tubular acidosis (HP:0001947)1.76360408
143Abdominal distention (HP:0003270)1.76259370
144Distal lower limb amyotrophy (HP:0008944)1.76164541
145Mildly elevated creatine phosphokinase (HP:0008180)1.76104051
146Abnormality of purine metabolism (HP:0004352)1.76090008
147Generalized aminoaciduria (HP:0002909)1.75480327
148Hypophosphatemic rickets (HP:0004912)1.74554518
149Abnormality of the distal phalanges of the toes (HP:0010182)1.74392738
150Ileus (HP:0002595)1.74353395
151Abnormality of the labia majora (HP:0012881)1.74028680
152Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73820528
153Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73654113
154Nemaline bodies (HP:0003798)1.72562676
155Abnormal glucose tolerance (HP:0001952)1.72024605
156Dicarboxylic aciduria (HP:0003215)1.71493854
157Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71493854
158Neonatal hypoglycemia (HP:0001998)1.71238037
159Metaphyseal cupping (HP:0003021)1.70350893
160Acute myeloid leukemia (HP:0004808)1.66613996
161Esophageal varix (HP:0002040)1.65213112
162Thrombocytosis (HP:0001894)1.64509759
163Colitis (HP:0002583)1.63294439
164Lymphangioma (HP:0100764)1.63071000
165Increased purine levels (HP:0004368)1.61954502
166Hyperuricemia (HP:0002149)1.61954502
167Generalized muscle weakness (HP:0003324)1.61623785
168Hyperinsulinemic hypoglycemia (HP:0000825)1.61601476
169Abnormality of glycine metabolism (HP:0010895)1.60559916
170Abnormality of serine family amino acid metabolism (HP:0010894)1.60559916
171Neonatal death (HP:0003811)1.59547951
172Papillary thyroid carcinoma (HP:0002895)1.58185218
173Abnormality of skeletal muscle fiber size (HP:0012084)1.57753661
174Myotonia (HP:0002486)1.57098807
175Abnormality of proline metabolism (HP:0010907)1.56151361
176Hydroxyprolinuria (HP:0003080)1.56151361
177Neoplasm of the rectum (HP:0100743)1.55605611
178Reduced subcutaneous adipose tissue (HP:0003758)1.55379661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.86908614
2ACVR1B3.38586255
3EPHA23.24130619
4TRIB33.20027167
5PKN23.03463111
6LATS12.72959904
7AKT32.55682462
8BCKDK2.18280478
9FER2.12070434
10LMTK22.08328022
11MAP3K22.07604080
12OBSCN2.07579713
13STK392.07263124
14PDK42.06556010
15PDK32.06556010
16TAOK32.04526259
17FLT32.03814910
18MAP3K122.00827704
19FRK2.00198357
20EIF2AK31.96124456
21PBK1.93650024
22EEF2K1.84002227
23NEK91.83277864
24MAP4K21.83269282
25TRIM281.74793117
26NUAK11.69603912
27MAPKAPK31.63162194
28DMPK1.57715575
29PTK61.57175671
30TRPM71.56793316
31MAP2K31.52824254
32SIK11.47297010
33STK31.46219746
34TGFBR21.38414328
35IRAK31.36524899
36ERBB41.34772976
37CAMK1D1.34463926
38PDK21.33048667
39JAK31.31354956
40CDK121.30755417
41TYK21.30727034
42MAP3K31.26656730
43MAP4K11.25789930
44NEK61.23699844
45RIPK11.20792765
46LRRK21.20742848
47TBK11.19706055
48CSF1R1.15165166
49NEK21.15087692
50PHKG21.13873372
51PHKG11.13873372
52BRSK21.13559337
53KIT1.10609060
54STK101.10545283
55RPS6KA41.07912648
56FGFR21.07508544
57PRKAA21.06191646
58STK41.05884183
59JAK11.05408359
60NEK11.03838511
61BMPR1B1.03509624
62PNCK1.02717772
63TIE10.99079646
64ZAP700.95664744
65PIK3CA0.94070018
66STK240.93791708
67PDGFRA0.92641358
68PTK20.92571974
69PLK40.91562218
70FGFR10.88203557
71SGK30.87771046
72BRD40.85506110
73TESK10.84542853
74EIF2AK10.83230270
75ERN10.82956283
76NLK0.81185338
77OXSR10.81149602
78PRKAA10.80294571
79MTOR0.78730335
80WEE10.76522481
81PDPK10.76407396
82FGFR40.75361487
83CDK60.72132100
84MAP3K70.71731963
85MAP3K140.71443476
86CHUK0.68695789
87INSRR0.68423899
88PDGFRB0.68062874
89CAMK1G0.67428437
90JAK20.66934153
91PIK3CG0.66639663
92PRKG20.66585427
93EPHB10.65345580
94FGFR30.65310445
95NME20.63516874
96SGK20.63329689
97MYLK0.62697934
98TTK0.62685119
99PIM10.62431284
100STK38L0.61997587
101PRKCI0.60375851
102RPS6KB20.60241418
103SCYL20.60166510
104MST1R0.59234334
105TNIK0.57018403
106ITK0.55394546
107ERBB30.54995162
108DDR20.51984459
109STK380.51621210
110MAP3K10.51544795
111TNK20.51032187
112CDK40.50734888
113ERBB20.50626962
114CAMK2D0.50567867
115MET0.49874477
116PRKD10.49588022
117IKBKB0.49435338
118RPS6KB10.45262796
119MAP3K80.44167387
120RET0.44154334
121WNK40.43561667
122MAP2K10.42829551
123AKT20.42814359
124EPHA30.42811572
125MAP3K50.42746312
126AURKB0.41961031
127TEC0.41902676
128MAP3K100.41855789
129RPS6KA60.40800367
130CSK0.40058236
131MST40.39970196
132WNK10.39673425
133BCR0.39536147
134PDK10.39068283
135ZAK0.38420387
136IKBKE0.38248641
137LATS20.38229762
138RPS6KC10.36771940
139RPS6KL10.36771940
140MAPK110.35881132
141TAF10.35571256
142MAP3K60.35513718
143YES10.34322024
144MELK0.33732227
145PAK30.32717720
146CSNK1E0.32288848
147ILK0.32044333
148PRKCE0.31793344
149TAOK10.29021120
150SIK30.27047506
151FGR0.26835712

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.26464349
2Propanoate metabolism_Homo sapiens_hsa006402.58510753
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54813878
4Fatty acid degradation_Homo sapiens_hsa000712.50678147
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43971778
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.36807273
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.16018170
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05507416
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99189940
10Histidine metabolism_Homo sapiens_hsa003401.94440183
11Fatty acid metabolism_Homo sapiens_hsa012121.73011955
12Retinol metabolism_Homo sapiens_hsa008301.70496132
13Insulin resistance_Homo sapiens_hsa049311.70113868
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69611836
15Mineral absorption_Homo sapiens_hsa049781.67219683
16Chemical carcinogenesis_Homo sapiens_hsa052041.65456207
17Selenocompound metabolism_Homo sapiens_hsa004501.63852169
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63497530
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.62731526
20Lysine degradation_Homo sapiens_hsa003101.59683673
21Carbon metabolism_Homo sapiens_hsa012001.54415318
22Nitrogen metabolism_Homo sapiens_hsa009101.54312522
23Sphingolipid metabolism_Homo sapiens_hsa006001.52712553
24Viral myocarditis_Homo sapiens_hsa054161.51218615
25Complement and coagulation cascades_Homo sapiens_hsa046101.39514108
26Circadian rhythm_Homo sapiens_hsa047101.38550110
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37909197
28Bile secretion_Homo sapiens_hsa049761.36650440
29Fatty acid elongation_Homo sapiens_hsa000621.35717839
30Starch and sucrose metabolism_Homo sapiens_hsa005001.35453648
31Dilated cardiomyopathy_Homo sapiens_hsa054141.34799463
32Vitamin B6 metabolism_Homo sapiens_hsa007501.34124398
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.33869062
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.30754133
35Small cell lung cancer_Homo sapiens_hsa052221.28934189
36PPAR signaling pathway_Homo sapiens_hsa033201.27772537
37Toxoplasmosis_Homo sapiens_hsa051451.27122451
38Phenylalanine metabolism_Homo sapiens_hsa003601.26229925
39Caffeine metabolism_Homo sapiens_hsa002321.15753536
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14420159
41Arginine and proline metabolism_Homo sapiens_hsa003301.11376625
42Tight junction_Homo sapiens_hsa045301.09970398
43Other glycan degradation_Homo sapiens_hsa005111.09620665
44AMPK signaling pathway_Homo sapiens_hsa041521.08920674
45Fat digestion and absorption_Homo sapiens_hsa049751.06570174
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06540795
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.05005166
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04133945
49Glutathione metabolism_Homo sapiens_hsa004801.03486301
50Adherens junction_Homo sapiens_hsa045201.01936112
51Focal adhesion_Homo sapiens_hsa045101.01557494
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01378797
53ABC transporters_Homo sapiens_hsa020101.00798356
54Non-homologous end-joining_Homo sapiens_hsa034501.00640884
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00379789
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.99473037
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99120251
58Renin-angiotensin system_Homo sapiens_hsa046140.98249001
59Pyruvate metabolism_Homo sapiens_hsa006200.97749910
60Legionellosis_Homo sapiens_hsa051340.97697833
61Insulin signaling pathway_Homo sapiens_hsa049100.97043470
62mTOR signaling pathway_Homo sapiens_hsa041500.96334729
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96120429
64Chronic myeloid leukemia_Homo sapiens_hsa052200.95351127
65Tyrosine metabolism_Homo sapiens_hsa003500.94821776
66Butanoate metabolism_Homo sapiens_hsa006500.92790370
67Antigen processing and presentation_Homo sapiens_hsa046120.92662728
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90763719
69Leishmaniasis_Homo sapiens_hsa051400.90666826
70Pancreatic secretion_Homo sapiens_hsa049720.88917759
71Tryptophan metabolism_Homo sapiens_hsa003800.88454179
72Lysosome_Homo sapiens_hsa041420.88421858
73Fructose and mannose metabolism_Homo sapiens_hsa000510.87737128
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80320494
75Osteoclast differentiation_Homo sapiens_hsa043800.80014002
76Glucagon signaling pathway_Homo sapiens_hsa049220.79675879
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.78758426
78Amoebiasis_Homo sapiens_hsa051460.77514183
79Inositol phosphate metabolism_Homo sapiens_hsa005620.76528349
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76421378
81ECM-receptor interaction_Homo sapiens_hsa045120.76272002
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.75869205
83Influenza A_Homo sapiens_hsa051640.75325448
84Acute myeloid leukemia_Homo sapiens_hsa052210.74911388
85B cell receptor signaling pathway_Homo sapiens_hsa046620.74802375
86Galactose metabolism_Homo sapiens_hsa000520.72749172
87Pancreatic cancer_Homo sapiens_hsa052120.72413717
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72140545
89Apoptosis_Homo sapiens_hsa042100.71613775
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71570360
91beta-Alanine metabolism_Homo sapiens_hsa004100.71351165
92Glycerolipid metabolism_Homo sapiens_hsa005610.71279965
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70806988
94Vitamin digestion and absorption_Homo sapiens_hsa049770.70646906
95Protein digestion and absorption_Homo sapiens_hsa049740.70481835
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69983735
97Fatty acid biosynthesis_Homo sapiens_hsa000610.69566213
98Measles_Homo sapiens_hsa051620.68372631
99Biosynthesis of amino acids_Homo sapiens_hsa012300.67400777
100Platelet activation_Homo sapiens_hsa046110.67350910
101Vibrio cholerae infection_Homo sapiens_hsa051100.67180743
102Pentose phosphate pathway_Homo sapiens_hsa000300.66947263
103Proteoglycans in cancer_Homo sapiens_hsa052050.66179775
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64539080
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63771706
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.62835690
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62701634
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62316715
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62182491
110HIF-1 signaling pathway_Homo sapiens_hsa040660.61704316
111Herpes simplex infection_Homo sapiens_hsa051680.59521361
112Arginine biosynthesis_Homo sapiens_hsa002200.59382276
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.59218453
114Peroxisome_Homo sapiens_hsa041460.59114386
115Tuberculosis_Homo sapiens_hsa051520.58964405
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57474227
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57247163
118One carbon pool by folate_Homo sapiens_hsa006700.56484419
119Sulfur metabolism_Homo sapiens_hsa009200.56189198
120Viral carcinogenesis_Homo sapiens_hsa052030.53502772
121Dorso-ventral axis formation_Homo sapiens_hsa043200.53302228
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.52990307
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52660586
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.51932196
125MicroRNAs in cancer_Homo sapiens_hsa052060.51232770
126Prostate cancer_Homo sapiens_hsa052150.50897385
127FoxO signaling pathway_Homo sapiens_hsa040680.49783323
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49694019
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48862215
130Staphylococcus aureus infection_Homo sapiens_hsa051500.47972615
131Type II diabetes mellitus_Homo sapiens_hsa049300.47912376
132Malaria_Homo sapiens_hsa051440.47642144
133Hepatitis C_Homo sapiens_hsa051600.47247528
134Prolactin signaling pathway_Homo sapiens_hsa049170.45923072
135Thyroid cancer_Homo sapiens_hsa052160.45090782
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42180983
137N-Glycan biosynthesis_Homo sapiens_hsa005100.41653767
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39819158
139alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38180721
140Renin secretion_Homo sapiens_hsa049240.35727894
141Thyroid hormone synthesis_Homo sapiens_hsa049180.34738009
142Arachidonic acid metabolism_Homo sapiens_hsa005900.34347917
143Metabolic pathways_Homo sapiens_hsa011000.34092261
144Linoleic acid metabolism_Homo sapiens_hsa005910.33868979
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28398118

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