KIF18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kinetochore organization (GO:0051383)5.78581487
2meiotic chromosome segregation (GO:0045132)5.40896136
3CENP-A containing nucleosome assembly (GO:0034080)5.21444937
4chromatin remodeling at centromere (GO:0031055)5.16404530
5* mitotic metaphase plate congression (GO:0007080)5.15768041
6protein localization to kinetochore (GO:0034501)5.15685562
7mitotic sister chromatid segregation (GO:0000070)5.09276441
8kinetochore assembly (GO:0051382)5.08040580
9attachment of spindle microtubules to kinetochore (GO:0008608)5.02109964
10mitotic chromosome condensation (GO:0007076)4.96858146
11sister chromatid segregation (GO:0000819)4.85753062
12protein localization to chromosome, centromeric region (GO:0071459)4.70218720
13* metaphase plate congression (GO:0051310)4.67595990
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.61006646
15DNA replication-independent nucleosome assembly (GO:0006336)4.59792799
16DNA replication-independent nucleosome organization (GO:0034724)4.59792799
17histone exchange (GO:0043486)4.40645528
18* establishment of chromosome localization (GO:0051303)4.32733063
19protein K6-linked ubiquitination (GO:0085020)4.28453735
20regulation of spindle organization (GO:0090224)4.20178696
21nuclear pore organization (GO:0006999)4.17904522
22spindle checkpoint (GO:0031577)4.17587253
23nuclear pore complex assembly (GO:0051292)4.13709995
24DNA replication initiation (GO:0006270)4.10238726
25regulation of nuclear cell cycle DNA replication (GO:0033262)4.09392683
26DNA replication checkpoint (GO:0000076)4.06127171
27mitotic recombination (GO:0006312)4.00269187
28DNA strand elongation involved in DNA replication (GO:0006271)3.96287660
29telomere maintenance via semi-conservative replication (GO:0032201)3.89167585
30chromosome segregation (GO:0007059)3.87542914
31synapsis (GO:0007129)3.86819587
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.85246129
33telomere maintenance via recombination (GO:0000722)3.84290686
34spindle assembly checkpoint (GO:0071173)3.83713122
35DNA strand elongation (GO:0022616)3.81543874
36regulation of chromosome segregation (GO:0051983)3.81338150
37establishment of integrated proviral latency (GO:0075713)3.79470186
38DNA replication-dependent nucleosome assembly (GO:0006335)3.78119223
39DNA replication-dependent nucleosome organization (GO:0034723)3.78119223
40DNA unwinding involved in DNA replication (GO:0006268)3.77048526
41regulation of mitotic metaphase/anaphase transition (GO:0030071)3.75981706
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.73949193
43negative regulation of mitotic sister chromatid segregation (GO:0033048)3.73949193
44negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.73949193
45negative regulation of sister chromatid segregation (GO:0033046)3.73949193
46mitotic spindle checkpoint (GO:0071174)3.73767062
47negative regulation of chromosome segregation (GO:0051985)3.73580965
48regulation of mitotic spindle organization (GO:0060236)3.73317388
49positive regulation of chromosome segregation (GO:0051984)3.71947426
50regulation of centriole replication (GO:0046599)3.69480491
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.69383657
52mitotic spindle assembly checkpoint (GO:0007094)3.66416266
53mitotic nuclear envelope disassembly (GO:0007077)3.65606410
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.65470322
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.65252557
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.65252557
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.65252557
58regulation of sister chromatid segregation (GO:0033045)3.64219047
59regulation of mitotic sister chromatid separation (GO:0010965)3.64219047
60regulation of mitotic sister chromatid segregation (GO:0033047)3.64219047
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62295918
62protein localization to chromosome (GO:0034502)3.58808828
63regulation of centrosome cycle (GO:0046605)3.57059769
64* microtubule depolymerization (GO:0007019)3.53218242
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.53133079
66chromatin assembly or disassembly (GO:0006333)3.50441076
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50252436
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.47527158
69mitotic sister chromatid cohesion (GO:0007064)3.47304478
70DNA synthesis involved in DNA repair (GO:0000731)3.46561880
71telomere maintenance via telomere lengthening (GO:0010833)3.45123567
72histone-serine phosphorylation (GO:0035404)3.43949235
73regulation of sister chromatid cohesion (GO:0007063)3.41523271
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40534918
75centriole replication (GO:0007099)3.39451089
76double-strand break repair via nonhomologous end joining (GO:0006303)3.35397121
77non-recombinational repair (GO:0000726)3.35397121
78DNA ligation (GO:0006266)3.34327758
79membrane disassembly (GO:0030397)3.34114715
80nuclear envelope disassembly (GO:0051081)3.34114715
81DNA topological change (GO:0006265)3.34069684
82ATP-dependent chromatin remodeling (GO:0043044)3.33959645
83pore complex assembly (GO:0046931)3.32804676
84ventricular cardiac muscle cell development (GO:0055015)3.32153973
85mismatch repair (GO:0006298)3.30991952
86regulation of helicase activity (GO:0051095)3.28456886
87* mitotic cell cycle (GO:0000278)3.28029187
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27739008
89resolution of meiotic recombination intermediates (GO:0000712)3.19408935
90chromosome condensation (GO:0030261)3.19032310
91negative regulation of cell division (GO:0051782)3.17186438
92negative regulation of nuclear division (GO:0051784)3.16841700
93negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.16056232
94regulation of DNA endoreduplication (GO:0032875)3.14149257
95mitotic spindle organization (GO:0007052)3.13626674
96chromosome organization (GO:0051276)3.09761912
97replication fork processing (GO:0031297)3.08243435
98telomere maintenance (GO:0000723)3.07415064
99sister chromatid cohesion (GO:0007062)3.07384766
100mitotic G2/M transition checkpoint (GO:0044818)3.07139446
101mitotic cytokinesis (GO:0000281)3.06804999
102DNA packaging (GO:0006323)3.06677803
103nucleotide-excision repair, DNA gap filling (GO:0006297)3.05623857
104telomere organization (GO:0032200)3.04943156
105reciprocal DNA recombination (GO:0035825)3.04798166
106reciprocal meiotic recombination (GO:0007131)3.04798166
107regulation of telomere maintenance via telomerase (GO:0032210)3.03521386
108intra-S DNA damage checkpoint (GO:0031573)3.02798134
109DNA double-strand break processing (GO:0000729)3.02662244
110telomere maintenance via telomerase (GO:0007004)3.01791521
111regulation of centrosome duplication (GO:0010824)3.00355209
112regulation of mitotic spindle checkpoint (GO:1903504)2.98945015
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.98945015
114regulation of histone H3-K9 methylation (GO:0051570)2.97395011
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.97236278
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97236278
117negative regulation of mitosis (GO:0045839)2.95908661
118DNA geometric change (GO:0032392)2.95499515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.90770430
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human5.16573526
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.48986422
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.20166569
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97355002
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96370124
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67684706
8AR_21909140_ChIP-Seq_LNCAP_Human2.46604971
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.46219351
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.46124210
11* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.43130991
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41877322
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.38415932
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36129439
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.33261793
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29248793
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08586259
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08571753
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.04134678
20* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02326518
21E2F7_22180533_ChIP-Seq_HELA_Human10.7684266
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.97288908
23* VDR_23849224_ChIP-Seq_CD4+_Human1.95611918
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94777516
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.92195723
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91626558
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91446156
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88794433
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.87534768
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.84875639
31ELK1_19687146_ChIP-ChIP_HELA_Human1.81290286
32FOXP3_21729870_ChIP-Seq_TREG_Human1.76213176
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68704129
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68641458
35XRN2_22483619_ChIP-Seq_HELA_Human1.68563557
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68404007
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64940783
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61502738
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59658206
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58788025
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56896223
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52330717
43TTF2_22483619_ChIP-Seq_HELA_Human1.52193038
44DCP1A_22483619_ChIP-Seq_HELA_Human1.50826428
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49025133
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37678459
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36122532
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35352728
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33355401
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33250355
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32567849
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29472611
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29035529
54CIITA_25753668_ChIP-Seq_RAJI_Human1.22517223
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22040870
56MYC_18940864_ChIP-ChIP_HL60_Human1.21530327
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20389712
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20357669
59* GABP_19822575_ChIP-Seq_HepG2_Human1.17905538
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16012840
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15645245
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09644433
63ZNF274_21170338_ChIP-Seq_K562_Hela1.09409775
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.08310806
65KDM5A_27292631_Chip-Seq_BREAST_Human1.05935342
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04518479
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04278909
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.04257993
69* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04251185
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03164384
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03090926
72VDR_22108803_ChIP-Seq_LS180_Human1.02735740
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00577464
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00577464
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00577464
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99030205
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97539494
78SOX2_16153702_ChIP-ChIP_HESCs_Human0.96978861
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96764312
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.96033831
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.92065008
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.91379801
83EWS_26573619_Chip-Seq_HEK293_Human0.91259120
84ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91203050
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90838624
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90022702
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88675345
88IRF1_19129219_ChIP-ChIP_H3396_Human0.87284266
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84612156
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84541701
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84432970
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.81672058
93PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81479558
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80185033
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79610981
96KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76830013
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75808609
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75092741
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75076908
100TAF15_26573619_Chip-Seq_HEK293_Human0.73361651
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.72538988
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71580228
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.71341817
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.71239673
105SPI1_23547873_ChIP-Seq_NB4_Human0.71140915
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70754145
107IGF1R_20145208_ChIP-Seq_DFB_Human0.69749642
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69743135
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69686843
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.68360785
111FUS_26573619_Chip-Seq_HEK293_Human0.67570709
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.66191571
113SOX9_26525672_Chip-Seq_HEART_Mouse0.65334026
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.63461790
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.63437413
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.59818975
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.58591464
118P300_19829295_ChIP-Seq_ESCs_Human0.56898735
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.54681824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26376424
2MP0010094_abnormal_chromosome_stability4.90232560
3MP0003111_abnormal_nucleus_morphology4.76741581
4MP0008057_abnormal_DNA_replication4.24904219
5MP0003077_abnormal_cell_cycle4.00314477
6MP0008058_abnormal_DNA_repair3.75490026
7MP0004957_abnormal_blastocyst_morpholog3.69128988
8MP0008007_abnormal_cellular_replicative3.03250278
9MP0008877_abnormal_DNA_methylation2.79342757
10MP0008932_abnormal_embryonic_tissue2.50325861
11MP0006292_abnormal_olfactory_placode2.38895866
12MP0010307_abnormal_tumor_latency2.24901559
13MP0003786_premature_aging2.16093883
14MP0002396_abnormal_hematopoietic_system2.08187198
15MP0003136_yellow_coat_color2.01743965
16MP0003718_maternal_effect1.93559920
17MP0000350_abnormal_cell_proliferation1.92638090
18MP0003941_abnormal_skin_development1.91192431
19MP0003123_paternal_imprinting1.88100183
20MP0001188_hyperpigmentation1.78604896
21MP0002210_abnormal_sex_determination1.62439831
22MP0000490_abnormal_crypts_of1.59275886
23MP0001730_embryonic_growth_arrest1.55471384
24MP0004808_abnormal_hematopoietic_stem1.52014937
25MP0003121_genomic_imprinting1.44137405
26MP0002102_abnormal_ear_morphology1.42661228
27MP0001672_abnormal_embryogenesis/_devel1.42537188
28MP0005380_embryogenesis_phenotype1.42537188
29MP0000566_synostosis1.36272116
30MP0001697_abnormal_embryo_size1.33928597
31MP0001929_abnormal_gametogenesis1.32825643
32MP0000372_irregular_coat_pigmentation1.30613166
33MP0002085_abnormal_embryonic_tissue1.27870605
34MP0001145_abnormal_male_reproductive1.27548853
35MP0000313_abnormal_cell_death1.27355732
36MP0003950_abnormal_plasma_membrane1.25662658
37MP0001119_abnormal_female_reproductive1.23325271
38MP0002019_abnormal_tumor_incidence1.21624799
39MP0000653_abnormal_sex_gland1.21274516
40MP0003787_abnormal_imprinting1.21170011
41MP0006035_abnormal_mitochondrial_morpho1.14940006
42MP0003890_abnormal_embryonic-extraembry1.14838948
43MP0003984_embryonic_growth_retardation1.13731140
44MP0003937_abnormal_limbs/digits/tail_de1.13431008
45MP0006072_abnormal_retinal_apoptosis1.12061892
46MP0002697_abnormal_eye_size1.11925833
47MP0003315_abnormal_perineum_morphology1.11658410
48MP0009697_abnormal_copulation1.11171373
49MP0002080_prenatal_lethality1.10793690
50MP0002086_abnormal_extraembryonic_tissu1.10071450
51MP0002088_abnormal_embryonic_growth/wei1.10009056
52MP0001529_abnormal_vocalization1.09555110
53MP0001293_anophthalmia1.08720120
54MP0008995_early_reproductive_senescence1.05891618
55MP0002084_abnormal_developmental_patter1.05696190
56MP0002095_abnormal_skin_pigmentation1.03223681
57MP0002132_abnormal_respiratory_system1.01397592
58MP0002009_preneoplasia1.00009706
59MP0002277_abnormal_respiratory_mucosa0.99026255
60MP0004197_abnormal_fetal_growth/weight/0.98853546
61MP0002234_abnormal_pharynx_morphology0.97565296
62MP0010030_abnormal_orbit_morphology0.96196649
63MP0000427_abnormal_hair_cycle0.96068556
64MP0010352_gastrointestinal_tract_polyps0.95103451
65MP0000703_abnormal_thymus_morphology0.94241511
66MP0003763_abnormal_thymus_physiology0.93777782
67MP0005397_hematopoietic_system_phenotyp0.93080992
68MP0001545_abnormal_hematopoietic_system0.93080992
69MP0000647_abnormal_sebaceous_gland0.92701590
70MP0001346_abnormal_lacrimal_gland0.92083339
71MP0002938_white_spotting0.91951998
72MP0000358_abnormal_cell_content/0.91074609
73MP0003567_abnormal_fetal_cardiomyocyte0.90666900
74MP0003806_abnormal_nucleotide_metabolis0.90377060
75MP0000537_abnormal_urethra_morphology0.90135862
76MP0002160_abnormal_reproductive_system0.89868357
77MP0005389_reproductive_system_phenotype0.89793957
78MP0002398_abnormal_bone_marrow0.89726579
79MP0000015_abnormal_ear_pigmentation0.89105070
80MP0005395_other_phenotype0.89104200
81MP0009333_abnormal_splenocyte_physiolog0.86255483
82MP0003119_abnormal_digestive_system0.84848616
83MP0001286_abnormal_eye_development0.83862817
84MP0001186_pigmentation_phenotype0.80231926
85MP0002722_abnormal_immune_system0.80013571
86MP0003698_abnormal_male_reproductive0.78980385
87MP0000689_abnormal_spleen_morphology0.77064194
88MP0005391_vision/eye_phenotype0.76559438
89MP0005076_abnormal_cell_differentiation0.76304359
90MP0003861_abnormal_nervous_system0.75775156
91MP0002075_abnormal_coat/hair_pigmentati0.75191124
92MP0000432_abnormal_head_morphology0.74729916
93MP0000428_abnormal_craniofacial_morphol0.72734201
94MP0003938_abnormal_ear_development0.71274571
95MP0006036_abnormal_mitochondrial_physio0.70480869
96MP0005174_abnormal_tail_pigmentation0.70372373
97MP0000631_abnormal_neuroendocrine_gland0.70077959
98MP0003935_abnormal_craniofacial_develop0.69780583
99MP0009703_decreased_birth_body0.69741235
100MP0001919_abnormal_reproductive_system0.68948955
101MP0003699_abnormal_female_reproductive0.68509327
102MP0008789_abnormal_olfactory_epithelium0.68506647
103MP0002111_abnormal_tail_morphology0.68062677
104MP0000049_abnormal_middle_ear0.67117913
105MP0000858_altered_metastatic_potential0.66661731
106MP0002163_abnormal_gland_morphology0.66202184
107MP0003943_abnormal_hepatobiliary_system0.65890131
108MP0005408_hypopigmentation0.63493881
109MP0003755_abnormal_palate_morphology0.62701127
110MP0002429_abnormal_blood_cell0.62117063
111MP0002177_abnormal_outer_ear0.61573394
112MP0005075_abnormal_melanosome_morpholog0.61104742
113MP0001835_abnormal_antigen_presentation0.60763786
114MP0001299_abnormal_eye_distance/0.60718238
115MP0004147_increased_porphyrin_level0.60528946
116MP0005253_abnormal_eye_physiology0.59977356
117MP0002161_abnormal_fertility/fecundity0.59914479
118MP0005621_abnormal_cell_physiology0.59555727
119MP0005499_abnormal_olfactory_system0.58926039
120MP0005394_taste/olfaction_phenotype0.58926039
121MP0000383_abnormal_hair_follicle0.58613507
122MP0010678_abnormal_skin_adnexa0.58564541
123MP0003936_abnormal_reproductive_system0.58494116
124MP0002877_abnormal_melanocyte_morpholog0.57967346
125MP0000569_abnormal_digit_pigmentation0.57877094
126MP0002751_abnormal_autonomic_nervous0.57271133
127MP0009672_abnormal_birth_weight0.56625304
128MP0002249_abnormal_larynx_morphology0.56456568
129MP0002006_tumorigenesis0.56235449
130MP0001986_abnormal_taste_sensitivity0.55910260
131MP0000716_abnormal_immune_system0.55762640
132MP0002092_abnormal_eye_morphology0.54532489
133MP0002233_abnormal_nose_morphology0.53609865

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)6.41000453
2Chromosomal breakage induced by crosslinking agents (HP:0003221)6.40751176
3Abnormality of chromosome stability (HP:0003220)4.42447399
4Birth length less than 3rd percentile (HP:0003561)4.40124739
5Meckel diverticulum (HP:0002245)4.28457858
6Abnormality of the preputium (HP:0100587)4.16011788
7Aplasia/Hypoplasia of the uvula (HP:0010293)4.07531240
8Abnormality of the ileum (HP:0001549)4.07146699
9Impulsivity (HP:0100710)3.58531890
10Small intestinal stenosis (HP:0012848)3.53772547
11Duodenal stenosis (HP:0100867)3.53772547
12Patellar aplasia (HP:0006443)3.46601948
13Breast hypoplasia (HP:0003187)3.23395135
14Aplasia/Hypoplasia of the patella (HP:0006498)3.20206716
15Ectopic kidney (HP:0000086)3.17218500
16Myelodysplasia (HP:0002863)3.16154099
17Duplicated collecting system (HP:0000081)3.11790127
18Nephroblastoma (Wilms tumor) (HP:0002667)3.09998266
19Medulloblastoma (HP:0002885)3.06973755
20Clubbing of toes (HP:0100760)3.04550221
21Cortical dysplasia (HP:0002539)3.00049151
22Reticulocytopenia (HP:0001896)2.92088425
23Embryonal renal neoplasm (HP:0011794)2.91855148
24Abnormality of the renal collecting system (HP:0004742)2.91548449
25Sloping forehead (HP:0000340)2.90368620
26Abnormality of the duodenum (HP:0002246)2.86774338
27Abnormal lung lobation (HP:0002101)2.86079566
28Abnormality of the labia minora (HP:0012880)2.83277327
29Supernumerary spleens (HP:0009799)2.76753272
30Abnormality of the carotid arteries (HP:0005344)2.72641593
31Bone marrow hypocellularity (HP:0005528)2.71836383
32Colon cancer (HP:0003003)2.71771212
33Absent radius (HP:0003974)2.64846265
34Volvulus (HP:0002580)2.54122322
35Absent thumb (HP:0009777)2.53885378
36Absent forearm bone (HP:0003953)2.52954997
37Aplasia involving forearm bones (HP:0009822)2.52954997
38Short thumb (HP:0009778)2.48847989
39Triphalangeal thumb (HP:0001199)2.47504328
40Abnormality of DNA repair (HP:0003254)2.45587711
41Prostate neoplasm (HP:0100787)2.42321873
42Abnormality of the pons (HP:0007361)2.38097652
43Hypoplastic pelvis (HP:0008839)2.37905897
44Aplastic anemia (HP:0001915)2.32009981
45Abnormal spermatogenesis (HP:0008669)2.30793582
46Hypoplasia of the pons (HP:0012110)2.27815248
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.24563526
48Tracheoesophageal fistula (HP:0002575)2.21518603
4911 pairs of ribs (HP:0000878)2.13011557
50Agnosia (HP:0010524)2.10628902
51Horseshoe kidney (HP:0000085)2.04879464
52Oral leukoplakia (HP:0002745)2.03086979
53Facial hemangioma (HP:0000329)2.02997426
54Premature graying of hair (HP:0002216)2.02307831
55Abnormal number of incisors (HP:0011064)2.01262746
56Cafe-au-lait spot (HP:0000957)2.00962235
57Choanal atresia (HP:0000453)1.99276715
58Increased hepatocellular lipid droplets (HP:0006565)1.99016438
59Carpal bone hypoplasia (HP:0001498)1.98165614
60Increased nuchal translucency (HP:0010880)1.97989111
61Selective tooth agenesis (HP:0001592)1.94913461
62Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91449526
63Aplasia/Hypoplasia of the sternum (HP:0006714)1.91167950
64Glioma (HP:0009733)1.90815263
65Arteriovenous malformation (HP:0100026)1.90257278
66Abnormality of the prostate (HP:0008775)1.88109229
67Rhabdomyosarcoma (HP:0002859)1.87705032
68Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86664789
69Oligodactyly (hands) (HP:0001180)1.86101832
70Astigmatism (HP:0000483)1.84905271
71Prominent nose (HP:0000448)1.80992702
72Neoplasm of the pancreas (HP:0002894)1.80991239
73Capillary hemangiomas (HP:0005306)1.79330635
74Rough bone trabeculation (HP:0100670)1.78650332
75Degeneration of anterior horn cells (HP:0002398)1.78575189
76Abnormality of the anterior horn cell (HP:0006802)1.78575189
77Small hand (HP:0200055)1.77041396
78Cleft eyelid (HP:0000625)1.73665449
79Abnormality of the fingertips (HP:0001211)1.72901863
80Oligodactyly (HP:0012165)1.71899154
81Ependymoma (HP:0002888)1.71496199
82Squamous cell carcinoma (HP:0002860)1.71486604
83Abnormality of chromosome segregation (HP:0002916)1.70564640
84Long clavicles (HP:0000890)1.69160323
85Septo-optic dysplasia (HP:0100842)1.69024286
86Lipid accumulation in hepatocytes (HP:0006561)1.68198937
87Abnormal auditory evoked potentials (HP:0006958)1.67658245
88Ovarian neoplasm (HP:0100615)1.67346201
89Embryonal neoplasm (HP:0002898)1.67291333
90Acute myeloid leukemia (HP:0004808)1.67236473
91Median cleft lip (HP:0000161)1.66510379
92Atresia of the external auditory canal (HP:0000413)1.66489776
93Lymphoma (HP:0002665)1.66488061
94Preaxial hand polydactyly (HP:0001177)1.65234008
95Abnormality of the septum pellucidum (HP:0007375)1.64762250
96Dandy-Walker malformation (HP:0001305)1.64655839
97Azoospermia (HP:0000027)1.63459276
98Neoplasm of the colon (HP:0100273)1.63377206
99Rib fusion (HP:0000902)1.63375484
100Short middle phalanx of the 5th finger (HP:0004220)1.62945463
101Acute lymphatic leukemia (HP:0006721)1.61435662
102Missing ribs (HP:0000921)1.61282575
103Abnormality of methionine metabolism (HP:0010901)1.59511216
104Holoprosencephaly (HP:0001360)1.59204086
105Deep philtrum (HP:0002002)1.58648938
106Leukopenia (HP:0001882)1.57840010
107Oligohydramnios (HP:0001562)1.57561345
108Acute necrotizing encephalopathy (HP:0006965)1.57294117
109Molar tooth sign on MRI (HP:0002419)1.57276282
110Abnormality of midbrain morphology (HP:0002418)1.57276282
111Abnormality of the proximal phalanges of the hand (HP:0009834)1.56915030
112Neoplasm of the oral cavity (HP:0100649)1.56843900
113Amaurosis fugax (HP:0100576)1.56763892
114Microtia (HP:0008551)1.56713572
115Abnormality of the heme biosynthetic pathway (HP:0010472)1.56650517
116Absent septum pellucidum (HP:0001331)1.56208519
117Supernumerary bones of the axial skeleton (HP:0009144)1.55783505
118Neoplasm of striated muscle (HP:0009728)1.55424634
119Abnormality of cochlea (HP:0000375)1.55130542
120Abnormality of abdominal situs (HP:0011620)1.54721386
121Abdominal situs inversus (HP:0003363)1.54721386
122Duplication of thumb phalanx (HP:0009942)1.53981856
123Intestinal atresia (HP:0011100)1.53660879
124Cerebellar dysplasia (HP:0007033)1.53617277
125Hypopigmented skin patches (HP:0001053)1.52922210
126Breast aplasia (HP:0100783)1.52788919
127Abnormality of the incisor (HP:0000676)1.52304806
128Irregular epiphyses (HP:0010582)1.52154384
129Acute encephalopathy (HP:0006846)1.51508451
130Pancreatic fibrosis (HP:0100732)1.50355807
131Intestinal polyposis (HP:0200008)1.48840783
132Proximal placement of thumb (HP:0009623)1.47826623
133High pitched voice (HP:0001620)1.46834663
134Overlapping toe (HP:0001845)1.46639980
135Progressive external ophthalmoplegia (HP:0000590)1.46586706
136Pancreatic islet-cell hyperplasia (HP:0004510)1.46458189
137Increased CSF lactate (HP:0002490)1.46437654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.46745592
2CDC74.38724852
3WEE13.69975637
4NEK23.39706193
5PLK43.21886328
6BRSK23.08895899
7TTK2.95606754
8SRPK12.92248896
9ZAK2.79724273
10PLK12.48377538
11MKNK22.42762030
12TLK12.40529715
13VRK12.36973547
14MKNK12.29300204
15AURKB2.10550331
16PLK32.10364393
17ACVR1B1.80215375
18PNCK1.79394346
19CHEK21.78001864
20CDK121.76501219
21STK41.73283715
22ATR1.72703678
23BRSK11.71898687
24EIF2AK11.70719900
25VRK21.68240081
26CCNB11.67547200
27CDK71.51574167
28EIF2AK21.49089740
29NEK11.47325663
30TRIM281.46506328
31STK161.39406602
32CHEK11.28434858
33AURKA1.28165443
34BRD41.27808305
35STK38L1.26836213
36NME21.24065758
37RPS6KA41.17149989
38PBK1.16873049
39ATM1.16282023
40TAF11.14714827
41CDK41.14441582
42NUAK11.13558714
43TNIK1.12669896
44STK101.11015147
45STK31.10178995
46DYRK31.08745120
47MST1R1.02923674
48PIM11.01262329
49MAP3K80.95400307
50LATS10.93992576
51BRAF0.91975366
52PASK0.91827294
53RPS6KB20.91240058
54BMPR1B0.90832106
55MELK0.90609762
56WNK30.89984444
57EIF2AK30.88600668
58IRAK30.85051829
59TSSK60.83843314
60RPS6KA50.81324153
61MET0.80951060
62CDK10.80430180
63CDK20.80025671
64MARK30.77556900
65YES10.75527352
66CLK10.74597750
67AKT30.74409585
68TEC0.72505628
69NME10.71760377
70EPHA20.70136877
71CDK80.66972232
72CDK60.66381044
73CDK30.63793535
74TXK0.63346053
75MST40.63102982
76IRAK40.63004029
77MAP3K140.60099029
78CSNK2A10.55469787
79NEK60.52333530
80STK390.51437607
81BCR0.50783820
82CDK90.48863660
83NEK90.48783160
84MAP4K10.47243621
85CHUK0.46496610
86SCYL20.44224122
87CSNK2A20.42004090
88ERBB40.41356338
89WNK40.38993157
90FGFR10.37800960
91MAP3K40.36729094
92PRKCI0.36558457
93PRKDC0.35024840
94AKT10.34877803
95PLK20.34311093
96AKT20.33916985
97ALK0.32895323
98MAPK140.32833393
99ERBB30.32293950
100CASK0.30727603
101BMPR20.29897715
102CDK180.28770216
103PAK10.28637782
104TRPM70.28203251
105PDK20.27419805
106CDK11A0.26505601
107IKBKB0.25991258
108RPS6KB10.25920125
109KSR10.25690230
110CDK150.25583800
111CSNK1E0.24831812
112MAP3K100.23659420
113LYN0.21970623
114JAK30.21889329
115GSK3B0.21117520
116CSNK1D0.20062334
117MAPKAPK50.19888763
118EEF2K0.19119808
119CSNK1G10.18465504
120PAK40.18152900
121CDK140.18020206
122TGFBR10.17865528
123PKN10.17442717
124MAPK10.16686017
125FRK0.16549469
126SGK20.15843109
127BTK0.15428146
128TESK20.14977499
129MAP3K120.14659020
130DYRK20.13505818
131TAOK20.12867650
132OXSR10.10452466

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49547598
2Mismatch repair_Homo sapiens_hsa034304.04403135
3Homologous recombination_Homo sapiens_hsa034403.71529201
4Fanconi anemia pathway_Homo sapiens_hsa034603.50032612
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43040986
6Cell cycle_Homo sapiens_hsa041103.32621311
7Base excision repair_Homo sapiens_hsa034103.06529513
8RNA polymerase_Homo sapiens_hsa030203.02187152
9Nucleotide excision repair_Homo sapiens_hsa034202.90677165
10Spliceosome_Homo sapiens_hsa030402.89554226
11RNA transport_Homo sapiens_hsa030132.78394406
12Non-homologous end-joining_Homo sapiens_hsa034502.72303413
13Basal transcription factors_Homo sapiens_hsa030222.46964718
14Systemic lupus erythematosus_Homo sapiens_hsa053222.33558069
15Pyrimidine metabolism_Homo sapiens_hsa002402.17542212
16One carbon pool by folate_Homo sapiens_hsa006702.14019314
17RNA degradation_Homo sapiens_hsa030182.06332864
18p53 signaling pathway_Homo sapiens_hsa041152.03752194
19Ribosome_Homo sapiens_hsa030101.99153009
20mRNA surveillance pathway_Homo sapiens_hsa030151.83327001
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73558929
22Proteasome_Homo sapiens_hsa030501.69230039
23Vitamin B6 metabolism_Homo sapiens_hsa007501.40770429
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40226169
25Purine metabolism_Homo sapiens_hsa002301.30855111
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29420898
27Propanoate metabolism_Homo sapiens_hsa006401.24190413
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21777914
29Herpes simplex infection_Homo sapiens_hsa051681.19806210
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15649289
31Viral carcinogenesis_Homo sapiens_hsa052031.15272936
32Oocyte meiosis_Homo sapiens_hsa041141.13155143
33Pyruvate metabolism_Homo sapiens_hsa006201.10413339
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09814628
35Epstein-Barr virus infection_Homo sapiens_hsa051691.09296038
36Alcoholism_Homo sapiens_hsa050341.08587248
37Parkinsons disease_Homo sapiens_hsa050121.01569209
38Oxidative phosphorylation_Homo sapiens_hsa001900.96062357
39Steroid biosynthesis_Homo sapiens_hsa001000.93577555
40MicroRNAs in cancer_Homo sapiens_hsa052060.92090430
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.89119227
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89081609
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88338501
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84072176
45HTLV-I infection_Homo sapiens_hsa051660.83788907
46Primary immunodeficiency_Homo sapiens_hsa053400.81890771
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76100992
48Small cell lung cancer_Homo sapiens_hsa052220.74753471
49Biosynthesis of amino acids_Homo sapiens_hsa012300.74596650
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.73439914
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71542089
52Antigen processing and presentation_Homo sapiens_hsa046120.65823777
53Measles_Homo sapiens_hsa051620.65004635
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63680274
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62832815
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60725014
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59896760
58Hematopoietic cell lineage_Homo sapiens_hsa046400.59255646
59Basal cell carcinoma_Homo sapiens_hsa052170.58688711
60Carbon metabolism_Homo sapiens_hsa012000.56382149
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53213559
62TGF-beta signaling pathway_Homo sapiens_hsa043500.51763804
63N-Glycan biosynthesis_Homo sapiens_hsa005100.51436937
64Fatty acid elongation_Homo sapiens_hsa000620.50892282
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50416814
66Apoptosis_Homo sapiens_hsa042100.50411863
67Autoimmune thyroid disease_Homo sapiens_hsa053200.50037009
68Influenza A_Homo sapiens_hsa051640.50029165
69Hepatitis B_Homo sapiens_hsa051610.49419316
70Allograft rejection_Homo sapiens_hsa053300.48174286
71Arachidonic acid metabolism_Homo sapiens_hsa005900.47642760
72Alzheimers disease_Homo sapiens_hsa050100.47189907
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47133022
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45906437
75Graft-versus-host disease_Homo sapiens_hsa053320.45034862
76Notch signaling pathway_Homo sapiens_hsa043300.42515137
77FoxO signaling pathway_Homo sapiens_hsa040680.42073479
78Legionellosis_Homo sapiens_hsa051340.41773969
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41758175
80Metabolic pathways_Homo sapiens_hsa011000.41482832
81Folate biosynthesis_Homo sapiens_hsa007900.41063762
82Colorectal cancer_Homo sapiens_hsa052100.39821080
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37612247
84Hippo signaling pathway_Homo sapiens_hsa043900.37536974
85Prostate cancer_Homo sapiens_hsa052150.37078265
86Asthma_Homo sapiens_hsa053100.37044878
87Thyroid cancer_Homo sapiens_hsa052160.36727523
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36382446
89Olfactory transduction_Homo sapiens_hsa047400.34671361
90Pathways in cancer_Homo sapiens_hsa052000.34659021
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31679937
92Selenocompound metabolism_Homo sapiens_hsa004500.29590310
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29515251
94Pancreatic cancer_Homo sapiens_hsa052120.28423012
95Melanoma_Homo sapiens_hsa052180.28199251
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28102664
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27754790
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.27102115
99Regulation of autophagy_Homo sapiens_hsa041400.26973721
100Lysine degradation_Homo sapiens_hsa003100.26846052
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26306003
102Phototransduction_Homo sapiens_hsa047440.26024218
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25911496
104Protein export_Homo sapiens_hsa030600.25863559
105Chronic myeloid leukemia_Homo sapiens_hsa052200.25249969
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24702126
107Hedgehog signaling pathway_Homo sapiens_hsa043400.24332427
108Wnt signaling pathway_Homo sapiens_hsa043100.22300938
109Leishmaniasis_Homo sapiens_hsa051400.22059463
110Sulfur relay system_Homo sapiens_hsa041220.21894195
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19169851
112Adherens junction_Homo sapiens_hsa045200.19134646
113Linoleic acid metabolism_Homo sapiens_hsa005910.18206569
114Sulfur metabolism_Homo sapiens_hsa009200.17862938
115Tight junction_Homo sapiens_hsa045300.17286109
116Pentose phosphate pathway_Homo sapiens_hsa000300.17143583
117Caffeine metabolism_Homo sapiens_hsa002320.16786834
118Butanoate metabolism_Homo sapiens_hsa006500.16457701
119Non-small cell lung cancer_Homo sapiens_hsa052230.16127938
120Nitrogen metabolism_Homo sapiens_hsa009100.15681400
121Huntingtons disease_Homo sapiens_hsa050160.15555108
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15289210
123TNF signaling pathway_Homo sapiens_hsa046680.14669626
124Shigellosis_Homo sapiens_hsa051310.14414348
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.14408508
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13664580
127Sphingolipid metabolism_Homo sapiens_hsa006000.12485427
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.12223794
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.11963045
130Malaria_Homo sapiens_hsa051440.11764314
131Glutathione metabolism_Homo sapiens_hsa004800.11552254
132Arginine and proline metabolism_Homo sapiens_hsa003300.11292412
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.11171641
134B cell receptor signaling pathway_Homo sapiens_hsa046620.10728214
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10709609
136Peroxisome_Homo sapiens_hsa041460.10678113
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10023766

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