

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | protein localization to kinetochore (GO:0034501) | 5.66741237 |
| 2 | protein localization to chromosome, centromeric region (GO:0071459) | 5.12359119 |
| 3 | * mitotic sister chromatid segregation (GO:0000070) | 5.01336271 |
| 4 | DNA unwinding involved in DNA replication (GO:0006268) | 4.98303413 |
| 5 | nuclear pore organization (GO:0006999) | 4.95151108 |
| 6 | nuclear pore complex assembly (GO:0051292) | 4.94839749 |
| 7 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.82413961 |
| 8 | * sister chromatid segregation (GO:0000819) | 4.79932391 |
| 9 | mitotic chromosome condensation (GO:0007076) | 4.65492281 |
| 10 | mitotic nuclear envelope disassembly (GO:0007077) | 4.52062931 |
| 11 | mitotic metaphase plate congression (GO:0007080) | 4.47438940 |
| 12 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.31055931 |
| 13 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.31055931 |
| 14 | positive regulation of chromosome segregation (GO:0051984) | 4.24330114 |
| 15 | membrane disassembly (GO:0030397) | 4.22033439 |
| 16 | nuclear envelope disassembly (GO:0051081) | 4.22033439 |
| 17 | regulation of spindle organization (GO:0090224) | 4.18378098 |
| 18 | DNA replication initiation (GO:0006270) | 4.13986997 |
| 19 | kinetochore organization (GO:0051383) | 4.07411943 |
| 20 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.99277356 |
| 21 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.97041465 |
| 22 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.97041465 |
| 23 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.97041465 |
| 24 | metaphase plate congression (GO:0051310) | 3.93747095 |
| 25 | mitotic sister chromatid cohesion (GO:0007064) | 3.81459443 |
| 26 | DNA replication checkpoint (GO:0000076) | 3.80840203 |
| 27 | protein localization to chromosome (GO:0034502) | 3.80663603 |
| 28 | regulation of histone H3-K9 methylation (GO:0051570) | 3.79298726 |
| 29 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.78829519 |
| 30 | DNA strand elongation (GO:0022616) | 3.78542213 |
| 31 | pore complex assembly (GO:0046931) | 3.78314990 |
| 32 | regulation of mitotic spindle organization (GO:0060236) | 3.72287376 |
| 33 | DNA ligation (GO:0006266) | 3.71714195 |
| 34 | heterochromatin organization (GO:0070828) | 3.67045088 |
| 35 | regulation of chromosome segregation (GO:0051983) | 3.65719671 |
| 36 | establishment of chromosome localization (GO:0051303) | 3.63982406 |
| 37 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.63296785 |
| 38 | DNA duplex unwinding (GO:0032508) | 3.60640089 |
| 39 | DNA geometric change (GO:0032392) | 3.60340449 |
| 40 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.58055717 |
| 41 | establishment of integrated proviral latency (GO:0075713) | 3.56968627 |
| 42 | chromatin assembly (GO:0031497) | 3.56056500 |
| 43 | * microtubule depolymerization (GO:0007019) | 3.53754474 |
| 44 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.52938532 |
| 45 | chromosome condensation (GO:0030261) | 3.52830819 |
| 46 | negative regulation of histone methylation (GO:0031061) | 3.50969277 |
| 47 | kinetochore assembly (GO:0051382) | 3.50845217 |
| 48 | regulation of sister chromatid cohesion (GO:0007063) | 3.48087124 |
| 49 | pre-miRNA processing (GO:0031054) | 3.45555688 |
| 50 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.43754088 |
| 51 | meiotic chromosome segregation (GO:0045132) | 3.43685856 |
| 52 | chromatin assembly or disassembly (GO:0006333) | 3.43425925 |
| 53 | DNA strand renaturation (GO:0000733) | 3.40947142 |
| 54 | spindle checkpoint (GO:0031577) | 3.37750492 |
| 55 | nuclear envelope organization (GO:0006998) | 3.37244008 |
| 56 | protein K6-linked ubiquitination (GO:0085020) | 3.35606185 |
| 57 | regulation of centrosome cycle (GO:0046605) | 3.35602213 |
| 58 | negative regulation of chromosome segregation (GO:0051985) | 3.33315744 |
| 59 | chromatin remodeling at centromere (GO:0031055) | 3.32291416 |
| 60 | mitotic recombination (GO:0006312) | 3.32187942 |
| 61 | * chromosome segregation (GO:0007059) | 3.30281900 |
| 62 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.29110578 |
| 63 | DNA replication-independent nucleosome organization (GO:0034724) | 3.29110578 |
| 64 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.28187345 |
| 65 | CENP-A containing nucleosome assembly (GO:0034080) | 3.25352359 |
| 66 | spindle assembly checkpoint (GO:0071173) | 3.24931586 |
| 67 | dosage compensation (GO:0007549) | 3.23734596 |
| 68 | regulation of telomere maintenance via telomerase (GO:0032210) | 3.23191333 |
| 69 | IMP biosynthetic process (GO:0006188) | 3.22569481 |
| 70 | DNA conformation change (GO:0071103) | 3.22378620 |
| 71 | telomere maintenance via recombination (GO:0000722) | 3.20986805 |
| 72 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.20111089 |
| 73 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.19440954 |
| 74 | negative regulation of sister chromatid segregation (GO:0033046) | 3.19440954 |
| 75 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.19440954 |
| 76 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.19440954 |
| 77 | replication fork processing (GO:0031297) | 3.17357231 |
| 78 | formation of translation preinitiation complex (GO:0001731) | 3.16961403 |
| 79 | regulation of translational fidelity (GO:0006450) | 3.16175766 |
| 80 | regulation of gene silencing by RNA (GO:0060966) | 3.14987972 |
| 81 | regulation of posttranscriptional gene silencing (GO:0060147) | 3.14987972 |
| 82 | regulation of gene silencing by miRNA (GO:0060964) | 3.14987972 |
| 83 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.14581010 |
| 84 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.14581010 |
| 85 | regulation of sister chromatid segregation (GO:0033045) | 3.14581010 |
| 86 | negative regulation of cell aging (GO:0090344) | 3.14160498 |
| 87 | mitotic spindle assembly checkpoint (GO:0007094) | 3.14092674 |
| 88 | nucleobase biosynthetic process (GO:0046112) | 3.13758599 |
| 89 | DNA packaging (GO:0006323) | 3.12790276 |
| 90 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.12550041 |
| 91 | mitotic spindle checkpoint (GO:0071174) | 3.12505822 |
| 92 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.09246575 |
| 93 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.08279786 |
| 94 | histone-serine phosphorylation (GO:0035404) | 3.08022403 |
| 95 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 3.06981779 |
| 96 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.06437587 |
| 97 | histone exchange (GO:0043486) | 3.02935424 |
| 98 | regulation of centriole replication (GO:0046599) | 3.01768280 |
| 99 | translesion synthesis (GO:0019985) | 3.00352221 |
| 100 | regulation of RNA export from nucleus (GO:0046831) | 2.97531184 |
| 101 | telomere maintenance via telomere lengthening (GO:0010833) | 2.96818995 |
| 102 | V(D)J recombination (GO:0033151) | 2.95804279 |
| 103 | ATP-dependent chromatin remodeling (GO:0043044) | 2.95547004 |
| 104 | ribosomal small subunit biogenesis (GO:0042274) | 2.94513993 |
| 105 | * mitotic cell cycle (GO:0000278) | 2.94406360 |
| 106 | spindle assembly involved in mitosis (GO:0090307) | 2.92753807 |
| 107 | DNA synthesis involved in DNA repair (GO:0000731) | 2.92627424 |
| 108 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.92584681 |
| 109 | regulation of DNA endoreduplication (GO:0032875) | 2.90540677 |
| 110 | maturation of SSU-rRNA (GO:0030490) | 2.89831796 |
| 111 | DNA topological change (GO:0006265) | 2.89315656 |
| 112 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.88444902 |
| 113 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 2.86172873 |
| 114 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.85138548 |
| 115 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.85138548 |
| 116 | spindle organization (GO:0007051) | 2.85064223 |
| 117 | mitotic spindle organization (GO:0007052) | 2.84100493 |
| 118 | * chromosome organization (GO:0051276) | 2.80325343 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.73716798 |
| 2 | * FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.57318236 |
| 3 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.24363191 |
| 4 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.78466121 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.35329280 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.21135919 |
| 7 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.81015486 |
| 8 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.69582245 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.67478377 |
| 10 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.36131395 |
| 11 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.35232386 |
| 12 | MYC_22102868_ChIP-Seq_BL_Human | 2.29579169 |
| 13 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.20856044 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.09816561 |
| 15 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.09779538 |
| 16 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 2.05524098 |
| 17 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.05343216 |
| 18 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.03887810 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.94637056 |
| 20 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.79335281 |
| 21 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.76865099 |
| 22 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.72401975 |
| 23 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.72382160 |
| 24 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.69899959 |
| 25 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68623460 |
| 26 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.68194522 |
| 27 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.58581724 |
| 28 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.57224486 |
| 29 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.56722389 |
| 30 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.56557754 |
| 31 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.53060858 |
| 32 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.51620634 |
| 33 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.49414608 |
| 34 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.46622991 |
| 35 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.46026162 |
| 36 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.45276993 |
| 37 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.42429166 |
| 38 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.42006139 |
| 39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.39381632 |
| 40 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.37438608 |
| 41 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.36341637 |
| 42 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.35305374 |
| 43 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.34341785 |
| 44 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.34196218 |
| 45 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.33871243 |
| 46 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.33171952 |
| 47 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.31537770 |
| 48 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.30228650 |
| 49 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.29256552 |
| 50 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.28868936 |
| 51 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.28764741 |
| 52 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.28126217 |
| 53 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.28062557 |
| 54 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27834547 |
| 55 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.26713739 |
| 56 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.26136856 |
| 57 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.25418971 |
| 58 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.25418971 |
| 59 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.25418971 |
| 60 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.24565024 |
| 61 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.23212536 |
| 62 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.23028564 |
| 63 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.21182501 |
| 64 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.19448995 |
| 65 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.18987454 |
| 66 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.18449760 |
| 67 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.18114495 |
| 68 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.17010023 |
| 69 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.16301076 |
| 70 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.13963539 |
| 71 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.12062525 |
| 72 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.11877047 |
| 73 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11830178 |
| 74 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.11318210 |
| 75 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.09414384 |
| 76 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.08687306 |
| 77 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.06046635 |
| 78 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05708192 |
| 79 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.02354875 |
| 80 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.01574458 |
| 81 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.99959864 |
| 82 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.99590713 |
| 83 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.98836644 |
| 84 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.98721428 |
| 85 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.97461433 |
| 86 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.97215902 |
| 87 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.95570797 |
| 88 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.94123978 |
| 89 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.93495502 |
| 90 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.93048602 |
| 91 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92861518 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91564247 |
| 93 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 0.91426654 |
| 94 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 0.91035972 |
| 95 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 0.88922060 |
| 96 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.87731822 |
| 97 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.87453302 |
| 98 | SOX2_18692474_ChIP-Seq_MESCs_Mouse | 0.85665886 |
| 99 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.85208644 |
| 100 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.84279317 |
| 101 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.83798031 |
| 102 | UTX_26944678_Chip-Seq_JUKART_Human | 0.83648138 |
| 103 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.82987686 |
| 104 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.82574410 |
| 105 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.82368462 |
| 106 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.82353549 |
| 107 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.81977171 |
| 108 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.80769694 |
| 109 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.80469061 |
| 110 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.80437829 |
| 111 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.80032216 |
| 112 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.79602675 |
| 113 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.79535353 |
| 114 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.78828631 |
| 115 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78536711 |
| 116 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.76070626 |
| 117 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.75100677 |
| 118 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.73731592 |
| 119 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.71339621 |
| 120 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.66208115 |
| 121 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.65023401 |
| 122 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.64469019 |
| 123 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.64252173 |
| 124 | POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.63315940 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003111_abnormal_nucleus_morphology | 4.67003741 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.51724135 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.36127513 |
| 4 | MP0003077_abnormal_cell_cycle | 3.86703987 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 3.83736404 |
| 6 | MP0008057_abnormal_DNA_replication | 3.75219944 |
| 7 | MP0010352_gastrointestinal_tract_polyps | 2.72445180 |
| 8 | MP0001730_embryonic_growth_arrest | 2.55207018 |
| 9 | MP0010307_abnormal_tumor_latency | 2.49933221 |
| 10 | MP0000350_abnormal_cell_proliferation | 2.43300094 |
| 11 | MP0000566_synostosis | 2.38157057 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.36177601 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.36161903 |
| 14 | MP0008058_abnormal_DNA_repair | 2.34789111 |
| 15 | MP0003136_yellow_coat_color | 2.33193528 |
| 16 | MP0005076_abnormal_cell_differentiation | 2.30216465 |
| 17 | MP0008932_abnormal_embryonic_tissue | 2.29973746 |
| 18 | MP0003705_abnormal_hypodermis_morpholog | 2.12444097 |
| 19 | MP0003123_paternal_imprinting | 2.07896687 |
| 20 | MP0005380_embryogenesis_phenotype | 2.05093527 |
| 21 | MP0001672_abnormal_embryogenesis/_devel | 2.05093527 |
| 22 | MP0002938_white_spotting | 1.96684198 |
| 23 | MP0001697_abnormal_embryo_size | 1.95107809 |
| 24 | MP0002396_abnormal_hematopoietic_system | 1.90765868 |
| 25 | MP0008877_abnormal_DNA_methylation | 1.87283326 |
| 26 | MP0002084_abnormal_developmental_patter | 1.87261040 |
| 27 | MP0002085_abnormal_embryonic_tissue | 1.86603361 |
| 28 | MP0003984_embryonic_growth_retardation | 1.84991237 |
| 29 | MP0002088_abnormal_embryonic_growth/wei | 1.81791063 |
| 30 | MP0004197_abnormal_fetal_growth/weight/ | 1.80716021 |
| 31 | MP0002086_abnormal_extraembryonic_tissu | 1.77034705 |
| 32 | MP0010030_abnormal_orbit_morphology | 1.73789590 |
| 33 | MP0002080_prenatal_lethality | 1.72505951 |
| 34 | MP0001346_abnormal_lacrimal_gland | 1.61292494 |
| 35 | MP0000049_abnormal_middle_ear | 1.58585751 |
| 36 | MP0004808_abnormal_hematopoietic_stem | 1.57608638 |
| 37 | MP0000490_abnormal_crypts_of | 1.56823528 |
| 38 | MP0009278_abnormal_bone_marrow | 1.54781629 |
| 39 | MP0003786_premature_aging | 1.52355845 |
| 40 | MP0002249_abnormal_larynx_morphology | 1.51300564 |
| 41 | MP0003121_genomic_imprinting | 1.49472711 |
| 42 | MP0000313_abnormal_cell_death | 1.41476120 |
| 43 | MP0009697_abnormal_copulation | 1.41124934 |
| 44 | MP0001545_abnormal_hematopoietic_system | 1.38608673 |
| 45 | MP0005397_hematopoietic_system_phenotyp | 1.38608673 |
| 46 | MP0002019_abnormal_tumor_incidence | 1.37669232 |
| 47 | MP0003890_abnormal_embryonic-extraembry | 1.35311458 |
| 48 | MP0001293_anophthalmia | 1.31333051 |
| 49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.26966400 |
| 50 | MP0002653_abnormal_ependyma_morphology | 1.26476631 |
| 51 | MP0009053_abnormal_anal_canal | 1.24049560 |
| 52 | MP0002234_abnormal_pharynx_morphology | 1.23108583 |
| 53 | MP0000537_abnormal_urethra_morphology | 1.18238116 |
| 54 | MP0001849_ear_inflammation | 1.18234470 |
| 55 | MP0009379_abnormal_foot_pigmentation | 1.17749446 |
| 56 | MP0003942_abnormal_urinary_system | 1.16493784 |
| 57 | MP0002210_abnormal_sex_determination | 1.16033228 |
| 58 | MP0003566_abnormal_cell_adhesion | 1.15880985 |
| 59 | MP0000703_abnormal_thymus_morphology | 1.13281120 |
| 60 | MP0003119_abnormal_digestive_system | 1.11470525 |
| 61 | MP0002163_abnormal_gland_morphology | 1.07983152 |
| 62 | MP0001929_abnormal_gametogenesis | 1.06383762 |
| 63 | MP0001145_abnormal_male_reproductive | 1.05668754 |
| 64 | MP0003937_abnormal_limbs/digits/tail_de | 1.05608426 |
| 65 | MP0004742_abnormal_vestibular_system | 1.03183877 |
| 66 | MP0004264_abnormal_extraembryonic_tissu | 1.02895630 |
| 67 | MP0004233_abnormal_muscle_weight | 1.02617599 |
| 68 | MP0000733_abnormal_muscle_development | 1.01840878 |
| 69 | MP0005023_abnormal_wound_healing | 1.00018005 |
| 70 | MP0001529_abnormal_vocalization | 0.99044651 |
| 71 | MP0009703_decreased_birth_body | 0.97808989 |
| 72 | MP0000428_abnormal_craniofacial_morphol | 0.97075231 |
| 73 | MP0009672_abnormal_birth_weight | 0.96607273 |
| 74 | MP0002111_abnormal_tail_morphology | 0.95863747 |
| 75 | MP0003718_maternal_effect | 0.95607842 |
| 76 | MP0001915_intracranial_hemorrhage | 0.94647890 |
| 77 | MP0003656_abnormal_erythrocyte_physiolo | 0.94301210 |
| 78 | MP0002092_abnormal_eye_morphology | 0.93843936 |
| 79 | MP0002398_abnormal_bone_marrow | 0.92448847 |
| 80 | MP0002722_abnormal_immune_system | 0.92402906 |
| 81 | MP0002116_abnormal_craniofacial_bone | 0.90525305 |
| 82 | MP0005621_abnormal_cell_physiology | 0.89925933 |
| 83 | MP0003941_abnormal_skin_development | 0.87592931 |
| 84 | MP0002160_abnormal_reproductive_system | 0.86524712 |
| 85 | MP0009333_abnormal_splenocyte_physiolog | 0.85420028 |
| 86 | MP0000653_abnormal_sex_gland | 0.85272544 |
| 87 | MP0003115_abnormal_respiratory_system | 0.84122732 |
| 88 | MP0002925_abnormal_cardiovascular_devel | 0.83914060 |
| 89 | MP0005384_cellular_phenotype | 0.83885867 |
| 90 | MP0008770_decreased_survivor_rate | 0.83795564 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.83409216 |
| 92 | MP0000432_abnormal_head_morphology | 0.82273769 |
| 93 | MP0003938_abnormal_ear_development | 0.81159273 |
| 94 | MP0000689_abnormal_spleen_morphology | 0.80491978 |
| 95 | MP0002697_abnormal_eye_size | 0.78946570 |
| 96 | MP0002877_abnormal_melanocyte_morpholog | 0.78832249 |
| 97 | MP0003935_abnormal_craniofacial_develop | 0.77135921 |
| 98 | MP0006035_abnormal_mitochondrial_morpho | 0.75912928 |
| 99 | MP0002233_abnormal_nose_morphology | 0.75576742 |
| 100 | MP0001286_abnormal_eye_development | 0.75529116 |
| 101 | MP0005501_abnormal_skin_physiology | 0.75367703 |
| 102 | MP0002751_abnormal_autonomic_nervous | 0.75333294 |
| 103 | MP0000534_abnormal_ureter_morphology | 0.75074152 |
| 104 | MP0003943_abnormal_hepatobiliary_system | 0.74805642 |
| 105 | MP0003315_abnormal_perineum_morphology | 0.74113493 |
| 106 | MP0000858_altered_metastatic_potential | 0.73527918 |
| 107 | MP0005391_vision/eye_phenotype | 0.73067881 |
| 108 | MP0002081_perinatal_lethality | 0.73063546 |
| 109 | MP0003861_abnormal_nervous_system | 0.70977581 |
| 110 | MP0003385_abnormal_body_wall | 0.70892812 |
| 111 | MP0009250_abnormal_appendicular_skeleto | 0.69502238 |
| 112 | MP0005171_absent_coat_pigmentation | 0.69245961 |
| 113 | MP0004133_heterotaxia | 0.69066000 |
| 114 | MP0008995_early_reproductive_senescence | 0.68142639 |
| 115 | MP0000477_abnormal_intestine_morphology | 0.67404134 |
| 116 | MP0002429_abnormal_blood_cell | 0.64567546 |
| 117 | MP0003699_abnormal_female_reproductive | 0.63959306 |
| 118 | MP0004185_abnormal_adipocyte_glucose | 0.63418553 |
| 119 | MP0006054_spinal_hemorrhage | 0.63182238 |
| 120 | MP0000647_abnormal_sebaceous_gland | 0.62798593 |
| 121 | MP0005083_abnormal_biliary_tract | 0.62488693 |
| 122 | MP0003448_altered_tumor_morphology | 0.62159867 |
| 123 | MP0000358_abnormal_cell_content/ | 0.61622755 |
| 124 | MP0003283_abnormal_digestive_organ | 0.61442883 |
| 125 | MP0000778_abnormal_nervous_system | 0.60497743 |
| 126 | MP0000266_abnormal_heart_morphology | 0.60360659 |
| 127 | MP0003755_abnormal_palate_morphology | 0.60358782 |
| 128 | MP0003698_abnormal_male_reproductive | 0.59927858 |
| 129 | MP0005187_abnormal_penis_morphology | 0.58794584 |
| 130 | MP0002932_abnormal_joint_morphology | 0.58765765 |
| 131 | MP0002114_abnormal_axial_skeleton | 0.57090423 |
| 132 | MP0010234_abnormal_vibrissa_follicle | 0.56715313 |
| 133 | MP0005623_abnormal_meninges_morphology | 0.56606251 |
| 134 | MP0001784_abnormal_fluid_regulation | 0.56275040 |
| 135 | MP0001119_abnormal_female_reproductive | 0.55459202 |
| 136 | MP0002161_abnormal_fertility/fecundity | 0.55114451 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Hypoplasia of the pons (HP:0012110) | 3.87394950 |
| 2 | Chromsome breakage (HP:0040012) | 3.69108496 |
| 3 | Ependymoma (HP:0002888) | 3.66744490 |
| 4 | Abnormality of the pons (HP:0007361) | 3.57112263 |
| 5 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.54423919 |
| 6 | Selective tooth agenesis (HP:0001592) | 3.31660365 |
| 7 | Birth length less than 3rd percentile (HP:0003561) | 3.19703594 |
| 8 | Impulsivity (HP:0100710) | 3.19061429 |
| 9 | Increased nuchal translucency (HP:0010880) | 3.03929063 |
| 10 | Patellar aplasia (HP:0006443) | 3.01150192 |
| 11 | Medulloblastoma (HP:0002885) | 2.96197705 |
| 12 | Abnormality of chromosome stability (HP:0003220) | 2.93235826 |
| 13 | Volvulus (HP:0002580) | 2.84829932 |
| 14 | Meckel diverticulum (HP:0002245) | 2.82764563 |
| 15 | Abnormality of the labia minora (HP:0012880) | 2.81545932 |
| 16 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.79791014 |
| 17 | Proximal placement of thumb (HP:0009623) | 2.78532644 |
| 18 | Deviation of the thumb (HP:0009603) | 2.76703855 |
| 19 | Breast hypoplasia (HP:0003187) | 2.74198858 |
| 20 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.72967966 |
| 21 | Short 4th metacarpal (HP:0010044) | 2.72967966 |
| 22 | Astrocytoma (HP:0009592) | 2.72862206 |
| 23 | Abnormality of the astrocytes (HP:0100707) | 2.72862206 |
| 24 | Cortical dysplasia (HP:0002539) | 2.72552551 |
| 25 | Abnormality of the ileum (HP:0001549) | 2.72449908 |
| 26 | Reticulocytopenia (HP:0001896) | 2.71676997 |
| 27 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.69979392 |
| 28 | Absent radius (HP:0003974) | 2.63381429 |
| 29 | Ectopic kidney (HP:0000086) | 2.61495339 |
| 30 | Rhabdomyosarcoma (HP:0002859) | 2.60100882 |
| 31 | High anterior hairline (HP:0009890) | 2.59613334 |
| 32 | Small intestinal stenosis (HP:0012848) | 2.55597682 |
| 33 | Duodenal stenosis (HP:0100867) | 2.55597682 |
| 34 | Basal cell carcinoma (HP:0002671) | 2.55206721 |
| 35 | Abnormality of the preputium (HP:0100587) | 2.52236609 |
| 36 | Horseshoe kidney (HP:0000085) | 2.46891279 |
| 37 | Aplasia involving forearm bones (HP:0009822) | 2.45407636 |
| 38 | Absent forearm bone (HP:0003953) | 2.45407636 |
| 39 | Triphalangeal thumb (HP:0001199) | 2.40081759 |
| 40 | Neoplasm of the oral cavity (HP:0100649) | 2.40064513 |
| 41 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.39026330 |
| 42 | Cafe-au-lait spot (HP:0000957) | 2.37568567 |
| 43 | Prominent nose (HP:0000448) | 2.37252259 |
| 44 | Myelodysplasia (HP:0002863) | 2.35506618 |
| 45 | Absent thumb (HP:0009777) | 2.34949474 |
| 46 | Facial hemangioma (HP:0000329) | 2.34782517 |
| 47 | Abnormal number of incisors (HP:0011064) | 2.33681519 |
| 48 | Colon cancer (HP:0003003) | 2.33152693 |
| 49 | Glioma (HP:0009733) | 2.32313895 |
| 50 | Neoplasm of striated muscle (HP:0009728) | 2.30737352 |
| 51 | Atresia of the external auditory canal (HP:0000413) | 2.29532823 |
| 52 | High pitched voice (HP:0001620) | 2.29219156 |
| 53 | Duplication of thumb phalanx (HP:0009942) | 2.28145749 |
| 54 | Carpal bone hypoplasia (HP:0001498) | 2.23272113 |
| 55 | Heterotopia (HP:0002282) | 2.21224501 |
| 56 | Rib fusion (HP:0000902) | 2.18615344 |
| 57 | Missing ribs (HP:0000921) | 2.17580558 |
| 58 | Agnosia (HP:0010524) | 2.17411566 |
| 59 | Aplasia/hypoplasia of the humerus (HP:0006507) | 2.14107186 |
| 60 | Abnormality of the carotid arteries (HP:0005344) | 2.12835419 |
| 61 | Abnormality of abdominal situs (HP:0011620) | 2.12696564 |
| 62 | Abdominal situs inversus (HP:0003363) | 2.12696564 |
| 63 | Abnormality of the duodenum (HP:0002246) | 2.12326366 |
| 64 | Abnormality of cochlea (HP:0000375) | 2.12315106 |
| 65 | Sloping forehead (HP:0000340) | 2.12149626 |
| 66 | Long eyelashes (HP:0000527) | 2.11407004 |
| 67 | Intestinal fistula (HP:0100819) | 2.10158427 |
| 68 | Morphological abnormality of the inner ear (HP:0011390) | 2.05221181 |
| 69 | Broad distal phalanx of finger (HP:0009836) | 2.04948928 |
| 70 | Thin ribs (HP:0000883) | 2.04311666 |
| 71 | Abnormality of reticulocytes (HP:0004312) | 2.04077212 |
| 72 | Abnormality of the renal collecting system (HP:0004742) | 2.02877015 |
| 73 | Abnormality of the anterior horn cell (HP:0006802) | 2.02192105 |
| 74 | Degeneration of anterior horn cells (HP:0002398) | 2.02192105 |
| 75 | Squamous cell carcinoma (HP:0002860) | 2.02093675 |
| 76 | Abnormality of the fingertips (HP:0001211) | 2.01895585 |
| 77 | Neoplasm of the pancreas (HP:0002894) | 2.01353142 |
| 78 | Short humerus (HP:0005792) | 2.01255236 |
| 79 | Bilateral microphthalmos (HP:0007633) | 2.01089941 |
| 80 | Tracheoesophageal fistula (HP:0002575) | 1.97813207 |
| 81 | Embryonal renal neoplasm (HP:0011794) | 1.95868134 |
| 82 | Microvesicular hepatic steatosis (HP:0001414) | 1.95714674 |
| 83 | Clubbing of toes (HP:0100760) | 1.95599475 |
| 84 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.94889557 |
| 85 | Overriding aorta (HP:0002623) | 1.94833472 |
| 86 | Abnormality of DNA repair (HP:0003254) | 1.94696966 |
| 87 | Supernumerary spleens (HP:0009799) | 1.94183855 |
| 88 | Gastrointestinal carcinoma (HP:0002672) | 1.93588132 |
| 89 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.93588132 |
| 90 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.92061268 |
| 91 | Overlapping toe (HP:0001845) | 1.91541473 |
| 92 | Short thumb (HP:0009778) | 1.90810775 |
| 93 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.87194883 |
| 94 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.86840509 |
| 95 | Absent epiphyses (HP:0010577) | 1.86840509 |
| 96 | Skull defect (HP:0001362) | 1.86355591 |
| 97 | Abnormality of the 4th metacarpal (HP:0010012) | 1.85724203 |
| 98 | Abnormal lung lobation (HP:0002101) | 1.84793057 |
| 99 | Hyperacusis (HP:0010780) | 1.84280711 |
| 100 | 11 pairs of ribs (HP:0000878) | 1.83813601 |
| 101 | Elfin facies (HP:0004428) | 1.83081205 |
| 102 | Oral leukoplakia (HP:0002745) | 1.82919690 |
| 103 | Bone marrow hypocellularity (HP:0005528) | 1.82370816 |
| 104 | Arteriovenous malformation (HP:0100026) | 1.81625471 |
| 105 | Rectovaginal fistula (HP:0000143) | 1.81558082 |
| 106 | Rectal fistula (HP:0100590) | 1.81558082 |
| 107 | Abnormality of chromosome segregation (HP:0002916) | 1.81438998 |
| 108 | Skin tags (HP:0010609) | 1.81347946 |
| 109 | Trismus (HP:0000211) | 1.80188943 |
| 110 | Ulnar bowing (HP:0003031) | 1.79765930 |
| 111 | Pseudobulbar signs (HP:0002200) | 1.79026493 |
| 112 | Sandal gap (HP:0001852) | 1.78538453 |
| 113 | Abnormal number of erythroid precursors (HP:0012131) | 1.78468577 |
| 114 | Renal duplication (HP:0000075) | 1.76741082 |
| 115 | Broad palm (HP:0001169) | 1.76517396 |
| 116 | Cerebellar dysplasia (HP:0007033) | 1.75173844 |
| 117 | Choanal atresia (HP:0000453) | 1.74745271 |
| 118 | Optic nerve coloboma (HP:0000588) | 1.74563984 |
| 119 | Insomnia (HP:0100785) | 1.74464633 |
| 120 | Sparse lateral eyebrow (HP:0005338) | 1.74065746 |
| 121 | Supernumerary ribs (HP:0005815) | 1.73506290 |
| 122 | Hypochromic microcytic anemia (HP:0004840) | 1.73092626 |
| 123 | Trigonocephaly (HP:0000243) | 1.72897257 |
| 124 | Poikilocytosis (HP:0004447) | 1.72129741 |
| 125 | Septo-optic dysplasia (HP:0100842) | 1.71760234 |
| 126 | Pallor (HP:0000980) | 1.71635778 |
| 127 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.70268001 |
| 128 | Ankle contracture (HP:0006466) | 1.70227012 |
| 129 | Abnormality of the calcaneus (HP:0008364) | 1.70186763 |
| 130 | Absent septum pellucidum (HP:0001331) | 1.70124714 |
| 131 | Preauricular skin tag (HP:0000384) | 1.70108661 |
| 132 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.69953706 |
| 133 | Duplicated collecting system (HP:0000081) | 1.69778573 |
| 134 | Broad thumb (HP:0011304) | 1.69444023 |
| 135 | Irregular epiphyses (HP:0010582) | 1.66596784 |
| 136 | Obsessive-compulsive behavior (HP:0000722) | 1.64881402 |
| 137 | Pendular nystagmus (HP:0012043) | 1.64170798 |
| 138 | Partial agenesis of the corpus callosum (HP:0001338) | 1.63920833 |
| 139 | Macrocytic anemia (HP:0001972) | 1.63644401 |
| 140 | Abnormality of homocysteine metabolism (HP:0010919) | 1.62199482 |
| 141 | Homocystinuria (HP:0002156) | 1.62199482 |
| 142 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.60695278 |
| 143 | Esophageal atresia (HP:0002032) | 1.59443350 |
| 144 | Abnormality of the septum pellucidum (HP:0007375) | 1.57080280 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 4.33724915 |
| 2 | CDC7 | 4.32841003 |
| 3 | BUB1 | 4.18351549 |
| 4 | NEK2 | 3.69804768 |
| 5 | WEE1 | 3.23636970 |
| 6 | VRK2 | 3.06693848 |
| 7 | EEF2K | 2.98621016 |
| 8 | TTK | 2.60950741 |
| 9 | MAP3K10 | 2.38502801 |
| 10 | SMG1 | 2.22216031 |
| 11 | NEK1 | 2.10999231 |
| 12 | EPHA2 | 2.09136830 |
| 13 | STK10 | 1.98474629 |
| 14 | PLK1 | 1.94858071 |
| 15 | TAF1 | 1.93513002 |
| 16 | RPS6KB2 | 1.90460992 |
| 17 | TLK1 | 1.76902091 |
| 18 | CDK4 | 1.76582828 |
| 19 | STK4 | 1.75716161 |
| 20 | AURKB | 1.74231686 |
| 21 | CDK7 | 1.71715343 |
| 22 | CHEK2 | 1.70876525 |
| 23 | EIF2AK1 | 1.67802458 |
| 24 | MAP3K8 | 1.57891432 |
| 25 | BRSK2 | 1.57881071 |
| 26 | ATR | 1.55024261 |
| 27 | BRD4 | 1.54466653 |
| 28 | CHEK1 | 1.47289526 |
| 29 | SRPK1 | 1.45284178 |
| 30 | TESK2 | 1.44856707 |
| 31 | PKN2 | 1.43451054 |
| 32 | PBK | 1.42535235 |
| 33 | PLK4 | 1.38828402 |
| 34 | BRSK1 | 1.37961952 |
| 35 | TSSK6 | 1.32266321 |
| 36 | PASK | 1.27089915 |
| 37 | NME1 | 1.25755419 |
| 38 | STK3 | 1.25460161 |
| 39 | PLK3 | 1.23698877 |
| 40 | ICK | 1.22411784 |
| 41 | AURKA | 1.22138354 |
| 42 | SCYL2 | 1.20716476 |
| 43 | DYRK3 | 1.20178065 |
| 44 | CDK6 | 1.17128004 |
| 45 | TRIB3 | 1.16323741 |
| 46 | LATS1 | 1.15364551 |
| 47 | MST1R | 1.12239010 |
| 48 | PAK4 | 1.10498251 |
| 49 | MKNK1 | 1.07161832 |
| 50 | MELK | 1.05985606 |
| 51 | ATM | 1.05935772 |
| 52 | ACVR1B | 1.03120063 |
| 53 | PIM1 | 1.03110546 |
| 54 | MTOR | 1.02651521 |
| 55 | CDK2 | 1.00422374 |
| 56 | ZAK | 0.98924556 |
| 57 | ALK | 0.98642062 |
| 58 | RPS6KA4 | 0.92871040 |
| 59 | CAMK1G | 0.91288093 |
| 60 | VRK1 | 0.85742983 |
| 61 | MKNK2 | 0.83899822 |
| 62 | LATS2 | 0.83233315 |
| 63 | EIF2AK2 | 0.83094548 |
| 64 | GRK6 | 0.81447312 |
| 65 | CDK1 | 0.77233269 |
| 66 | WNK4 | 0.77169863 |
| 67 | MAP4K1 | 0.73336543 |
| 68 | IRAK3 | 0.73236251 |
| 69 | LRRK2 | 0.72183092 |
| 70 | TTN | 0.71360610 |
| 71 | MAPKAPK5 | 0.69923058 |
| 72 | NME2 | 0.67977524 |
| 73 | PAK1 | 0.66776210 |
| 74 | BMX | 0.62796755 |
| 75 | CDK9 | 0.62637576 |
| 76 | TESK1 | 0.60473740 |
| 77 | MET | 0.60148740 |
| 78 | SIK1 | 0.59733975 |
| 79 | BRAF | 0.57078405 |
| 80 | TGFBR1 | 0.56867121 |
| 81 | AKT2 | 0.56861942 |
| 82 | MAPKAPK3 | 0.51711406 |
| 83 | NUAK1 | 0.49997073 |
| 84 | PAK2 | 0.48699829 |
| 85 | CSNK1D | 0.47921915 |
| 86 | CAMK1D | 0.47228762 |
| 87 | RPS6KA5 | 0.46726266 |
| 88 | WNK3 | 0.46373419 |
| 89 | FLT3 | 0.46097933 |
| 90 | PRKCI | 0.44699894 |
| 91 | CLK1 | 0.44480457 |
| 92 | ERBB4 | 0.43971230 |
| 93 | CSNK2A2 | 0.43639359 |
| 94 | CCNB1 | 0.43082429 |
| 95 | PRKDC | 0.42781272 |
| 96 | MAPK14 | 0.40881672 |
| 97 | CDK11A | 0.40548101 |
| 98 | MAPK11 | 0.39995342 |
| 99 | DYRK2 | 0.39832647 |
| 100 | CDK15 | 0.38412155 |
| 101 | STK16 | 0.38123163 |
| 102 | PDGFRA | 0.36956349 |
| 103 | PNCK | 0.36595567 |
| 104 | CSNK1E | 0.36350641 |
| 105 | CDK18 | 0.35324684 |
| 106 | CDK8 | 0.34827955 |
| 107 | CSNK2A1 | 0.34757610 |
| 108 | CDK3 | 0.33971813 |
| 109 | PTK6 | 0.33961288 |
| 110 | MARK3 | 0.33835076 |
| 111 | SIK2 | 0.33684666 |
| 112 | STK38L | 0.33367961 |
| 113 | AKT1 | 0.32408436 |
| 114 | MAPK1 | 0.32395207 |
| 115 | EIF2AK3 | 0.29658137 |
| 116 | GSK3B | 0.29449362 |
| 117 | FGFR1 | 0.29079800 |
| 118 | DYRK1B | 0.27679534 |
| 119 | EPHB2 | 0.27499064 |
| 120 | MAPKAPK2 | 0.26903391 |
| 121 | UHMK1 | 0.26501951 |
| 122 | RPS6KA1 | 0.26315639 |
| 123 | TAOK1 | 0.24539965 |
| 124 | PDK3 | 0.20265575 |
| 125 | PDK4 | 0.20265575 |
| 126 | CSF1R | 0.20172754 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.51172086 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.81178107 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.35997755 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.22357989 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.11350426 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.03758259 |
| 7 | Base excision repair_Homo sapiens_hsa03410 | 2.93148609 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.72711044 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.65078179 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.49801644 |
| 11 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.45623537 |
| 12 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 2.36916478 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.23538563 |
| 14 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.21765162 |
| 15 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.08990845 |
| 16 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.03758083 |
| 17 | Ribosome_Homo sapiens_hsa03010 | 1.88682904 |
| 18 | RNA polymerase_Homo sapiens_hsa03020 | 1.85355420 |
| 19 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.61409526 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.60411180 |
| 21 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.56588526 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.52903446 |
| 23 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.43808966 |
| 24 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.39208274 |
| 25 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.35397952 |
| 26 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.33464695 |
| 27 | Proteasome_Homo sapiens_hsa03050 | 1.18000414 |
| 28 | HTLV-I infection_Homo sapiens_hsa05166 | 1.13772238 |
| 29 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.13766256 |
| 30 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12900539 |
| 31 | Alcoholism_Homo sapiens_hsa05034 | 1.11480999 |
| 32 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.09811916 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.02107690 |
| 34 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.00212916 |
| 35 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.97315845 |
| 36 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.97232579 |
| 37 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.94692640 |
| 38 | Bladder cancer_Homo sapiens_hsa05219 | 0.94561622 |
| 39 | Huntingtons disease_Homo sapiens_hsa05016 | 0.93940707 |
| 40 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.93334557 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.91940687 |
| 42 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.91790382 |
| 43 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.90778502 |
| 44 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.89068533 |
| 45 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.88369853 |
| 46 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.85555943 |
| 47 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.84556216 |
| 48 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.84331284 |
| 49 | Parkinsons disease_Homo sapiens_hsa05012 | 0.83460748 |
| 50 | Thyroid cancer_Homo sapiens_hsa05216 | 0.81091307 |
| 51 | Colorectal cancer_Homo sapiens_hsa05210 | 0.80575849 |
| 52 | Lysine degradation_Homo sapiens_hsa00310 | 0.80171231 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.78852837 |
| 54 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.78626474 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.77698736 |
| 56 | Adherens junction_Homo sapiens_hsa04520 | 0.77622059 |
| 57 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.77108936 |
| 58 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.76886073 |
| 59 | Protein export_Homo sapiens_hsa03060 | 0.74964593 |
| 60 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.72755454 |
| 61 | Apoptosis_Homo sapiens_hsa04210 | 0.70928029 |
| 62 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.70459243 |
| 63 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.69986274 |
| 64 | Purine metabolism_Homo sapiens_hsa00230 | 0.68903225 |
| 65 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.68697813 |
| 66 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.67174271 |
| 67 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.66301106 |
| 68 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.64843249 |
| 69 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64232986 |
| 70 | Hepatitis B_Homo sapiens_hsa05161 | 0.63929061 |
| 71 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.63207055 |
| 72 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.61874263 |
| 73 | Prostate cancer_Homo sapiens_hsa05215 | 0.60718619 |
| 74 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.58577940 |
| 75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.58483888 |
| 76 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.57129420 |
| 77 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.54644196 |
| 78 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.54558279 |
| 79 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.54064153 |
| 80 | Pathways in cancer_Homo sapiens_hsa05200 | 0.53449030 |
| 81 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.51873234 |
| 82 | Viral myocarditis_Homo sapiens_hsa05416 | 0.49867672 |
| 83 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.47733265 |
| 84 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.47208403 |
| 85 | Endometrial cancer_Homo sapiens_hsa05213 | 0.46903471 |
| 86 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.46785795 |
| 87 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.46006981 |
| 88 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.45742098 |
| 89 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.43603004 |
| 90 | Shigellosis_Homo sapiens_hsa05131 | 0.43375313 |
| 91 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.43188543 |
| 92 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.42418066 |
| 93 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.42164273 |
| 94 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.41754970 |
| 95 | Measles_Homo sapiens_hsa05162 | 0.39201785 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.37820043 |
| 97 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.37816190 |
| 98 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.37709121 |
| 99 | Legionellosis_Homo sapiens_hsa05134 | 0.37644472 |
| 100 | Melanoma_Homo sapiens_hsa05218 | 0.37515616 |
| 101 | Tight junction_Homo sapiens_hsa04530 | 0.36605271 |
| 102 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.36454294 |
| 103 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35996467 |
| 104 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35578812 |
| 105 | Melanogenesis_Homo sapiens_hsa04916 | 0.34700946 |
| 106 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.34485870 |
| 107 | Metabolic pathways_Homo sapiens_hsa01100 | 0.33536008 |
| 108 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.33236504 |
| 109 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.32601705 |
| 110 | Alzheimers disease_Homo sapiens_hsa05010 | 0.32346647 |
| 111 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.32130499 |
| 112 | Glioma_Homo sapiens_hsa05214 | 0.31959609 |
| 113 | Influenza A_Homo sapiens_hsa05164 | 0.31636104 |
| 114 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.30935385 |
| 115 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.30928183 |
| 116 | Sulfur relay system_Homo sapiens_hsa04122 | 0.30327033 |
| 117 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.30154605 |
| 118 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.28326832 |
| 119 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27732627 |
| 120 | Focal adhesion_Homo sapiens_hsa04510 | 0.27402735 |
| 121 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.26690045 |
| 122 | Phototransduction_Homo sapiens_hsa04744 | 0.26654740 |
| 123 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.25845849 |
| 124 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.25270229 |
| 125 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.24240195 |
| 126 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.22553267 |
| 127 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.21732085 |
| 128 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.21673914 |
| 129 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.21538376 |
| 130 | Carbon metabolism_Homo sapiens_hsa01200 | 0.21259843 |
| 131 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.21048755 |
| 132 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.17391844 |
| 133 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.16814347 |
| 134 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.14802277 |
| 135 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.11595446 |
| 136 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.08812322 |

