KIF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.59773288
2left/right pattern formation (GO:0060972)7.59840581
3regulation of cilium movement (GO:0003352)7.39262234
4left/right axis specification (GO:0070986)6.54343912
5microtubule bundle formation (GO:0001578)6.13828289
6ventricular system development (GO:0021591)5.94236096
7intraciliary transport (GO:0042073)5.91559468
8cilium organization (GO:0044782)5.88679588
9cilium assembly (GO:0042384)5.73644629
10primary alcohol catabolic process (GO:0034310)5.62872944
11protein localization to cilium (GO:0061512)5.21399914
12vitamin transmembrane transport (GO:0035461)5.19849516
13one-carbon compound transport (GO:0019755)4.81861725
14ethanol metabolic process (GO:0006067)4.77499171
15regulation of microtubule-based movement (GO:0060632)4.67567227
16cellular component assembly involved in morphogenesis (GO:0010927)4.55416726
17cilium morphogenesis (GO:0060271)4.30041651
18diterpenoid biosynthetic process (GO:0016102)4.23244716
19centriole assembly (GO:0098534)4.22397866
20response to xenobiotic stimulus (GO:0009410)4.19551471
21negative regulation of B cell mediated immunity (GO:0002713)4.16156731
22negative regulation of immunoglobulin mediated immune response (GO:0002890)4.16156731
23lung epithelium development (GO:0060428)4.08442301
24* microtubule-based movement (GO:0007018)4.07637863
25cell projection assembly (GO:0030031)4.04080583
26negative regulation of T cell differentiation in thymus (GO:0033085)4.00259257
27tolerance induction (GO:0002507)3.89848711
28sperm capacitation (GO:0048240)3.85870480
29pyrimidine-containing compound transmembrane transport (GO:0072531)3.80116553
30ethanol oxidation (GO:0006069)3.75200828
31exogenous drug catabolic process (GO:0042738)3.57700384
32nucleoside diphosphate phosphorylation (GO:0006165)3.53286951
33negative regulation of humoral immune response (GO:0002921)3.49113391
34regulation of germinal center formation (GO:0002634)3.46470605
35nonmotile primary cilium assembly (GO:0035058)3.34811319
36retinoic acid metabolic process (GO:0042573)3.31686239
37terpenoid biosynthetic process (GO:0016114)3.31654724
38regulation of interleukin-5 production (GO:0032674)3.29757704
39positive regulation of tolerance induction (GO:0002645)3.27197585
40photoreceptor cell maintenance (GO:0045494)3.23168129
41sperm motility (GO:0030317)3.20186451
42aldehyde catabolic process (GO:0046185)3.17662506
43establishment of apical/basal cell polarity (GO:0035089)3.13811028
44determination of left/right symmetry (GO:0007368)3.13595449
45establishment or maintenance of monopolar cell polarity (GO:0061339)3.05897665
46establishment of monopolar cell polarity (GO:0061162)3.05897665
47drug catabolic process (GO:0042737)3.04023563
48glomerular epithelial cell development (GO:0072310)2.97575031
49regulation of collateral sprouting (GO:0048670)2.96771107
50determination of bilateral symmetry (GO:0009855)2.96422294
51behavioral response to nicotine (GO:0035095)2.92286660
52lateral ventricle development (GO:0021670)2.91438671
53smoothened signaling pathway (GO:0007224)2.88804855
54retinal cone cell development (GO:0046549)2.88209670
55specification of symmetry (GO:0009799)2.87478626
56protein polyglutamylation (GO:0018095)2.84535672
57regulation of interleukin-13 production (GO:0032656)2.81511541
58glutathione derivative metabolic process (GO:1901685)2.72569591
59glutathione derivative biosynthetic process (GO:1901687)2.72569591
60centriole replication (GO:0007099)2.71352155
61retinal rod cell development (GO:0046548)2.67451472
62cornea development in camera-type eye (GO:0061303)2.64294994
63* cytoplasmic microtubule organization (GO:0031122)2.58496656
64neurotransmitter metabolic process (GO:0042133)2.57339141
65negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56014070
66retinol metabolic process (GO:0042572)2.49832201
67primary alcohol metabolic process (GO:0034308)2.49494614
68hydrogen peroxide biosynthetic process (GO:0050665)2.48421826
69auditory behavior (GO:0031223)2.48349038
70organelle assembly (GO:0070925)2.47165254
71* microtubule-based process (GO:0007017)2.45972377
72negative regulation of inclusion body assembly (GO:0090084)2.45927717
73phosphatidylcholine biosynthetic process (GO:0006656)2.43960665
74O-glycan processing (GO:0016266)2.43549993
75sialylation (GO:0097503)2.42515831
76rRNA catabolic process (GO:0016075)2.40693424
77brain morphogenesis (GO:0048854)2.38637944
78vocalization behavior (GO:0071625)2.38472153
79neurotransmitter biosynthetic process (GO:0042136)2.38000307
80regulation of cilium assembly (GO:1902017)2.37807734
81limb development (GO:0060173)2.37015168
82appendage development (GO:0048736)2.37015168
83spinal cord motor neuron differentiation (GO:0021522)2.36950037
84regulation of autophagic vacuole assembly (GO:2000785)2.36388815
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35760387
86gamma-aminobutyric acid transport (GO:0015812)2.30051990
87regulation of tolerance induction (GO:0002643)2.29940747
88establishment of planar polarity (GO:0001736)2.27929045
89establishment of tissue polarity (GO:0007164)2.27929045
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.25943412
91reactive oxygen species biosynthetic process (GO:1903409)2.25088351
92oligosaccharide biosynthetic process (GO:0009312)2.24754564
93negative regulation of cytosolic calcium ion concentration (GO:0051481)2.23021797
94glycosphingolipid biosynthetic process (GO:0006688)2.21903157
95axonemal dynein complex assembly (GO:0070286)17.9142429
96cilium or flagellum-dependent cell motility (GO:0001539)15.1204119
97cilium movement (GO:0003341)13.4273138
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.5472393
99motile cilium assembly (GO:0044458)12.3751399
100epithelial cilium movement (GO:0003351)12.0089299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DROSHA_22980978_ChIP-Seq_HELA_Human3.62468340
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01220423
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72868959
4VDR_22108803_ChIP-Seq_LS180_Human2.40646746
5EZH2_22144423_ChIP-Seq_EOC_Human2.33100742
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.15058702
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08400621
8ZNF274_21170338_ChIP-Seq_K562_Hela1.96955328
9REST_21632747_ChIP-Seq_MESCs_Mouse1.76722837
10PIAS1_25552417_ChIP-Seq_VCAP_Human1.76578023
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74383767
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65514090
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62507059
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.56733909
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55780370
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55481782
17NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55079195
18* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38466593
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38120974
20PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38047809
21GBX2_23144817_ChIP-Seq_PC3_Human1.37784013
22AHR_22903824_ChIP-Seq_MCF-7_Human1.34194162
23TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32520084
24SMAD4_21799915_ChIP-Seq_A2780_Human1.31372797
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28037971
26BCAT_22108803_ChIP-Seq_LS180_Human1.27935492
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26700638
28STAT1_20625510_ChIP-Seq_HELA_Human1.25003696
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24726541
30STAT3_23295773_ChIP-Seq_U87_Human1.24703881
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.20707719
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19721788
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18172750
34* TCF4_23295773_ChIP-Seq_U87_Human1.15934931
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14687189
36SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14156782
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13471265
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13467763
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13360024
40TCF4_22108803_ChIP-Seq_LS180_Human1.12673264
41IGF1R_20145208_ChIP-Seq_DFB_Human1.12629278
42ETV1_20927104_ChIP-Seq_GIST48_Human1.12274782
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10806749
44CBP_20019798_ChIP-Seq_JUKART_Human1.10806749
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10787268
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10191488
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.10191488
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09890258
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09684469
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09684469
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.09545261
52SMRT_27268052_Chip-Seq_Bcells_Human1.08826111
53MYC_19829295_ChIP-Seq_ESCs_Human1.07884923
54PHF8_20622853_ChIP-Seq_HELA_Human1.07683702
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.07352664
56ER_23166858_ChIP-Seq_MCF-7_Human1.06925981
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06105749
58SMC4_20622854_ChIP-Seq_HELA_Human1.05647353
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05614195
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.05177583
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04110666
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04052735
63RUNX2_22187159_ChIP-Seq_PCA_Human1.02995873
64NCOR_22424771_ChIP-Seq_293T_Human1.02584860
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01728154
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01624396
67OCT4_20526341_ChIP-Seq_ESCs_Human1.01462754
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.01257880
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01119229
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00864982
71FOXA1_25552417_ChIP-Seq_VCAP_Human1.00484229
72CTCF_27219007_Chip-Seq_Bcells_Human1.00314562
73* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99999968
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99801482
75RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99434518
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98459689
77FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98436038
78NFYA_21822215_ChIP-Seq_K562_Human0.98291431
79AR_19668381_ChIP-Seq_PC3_Human0.97947244
80TBL1_22424771_ChIP-Seq_293T_Human0.97707152
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.97512742
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96278849
83TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95462134
84TP53_18474530_ChIP-ChIP_U2OS_Human0.95389724
85REST_18959480_ChIP-ChIP_MESCs_Mouse0.95187466
86TP63_23658742_ChIP-Seq_EP156T_Human0.95092739
87HNFA_21074721_ChIP-Seq_CACO-2_Human0.95079844
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94472317
89AR_20517297_ChIP-Seq_VCAP_Human0.94377288
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93863239
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93827887
92RBPJ_21746931_ChIP-Seq_IB4_Human0.93813560
93ERA_21632823_ChIP-Seq_H3396_Human0.93769454
94AR_25329375_ChIP-Seq_VCAP_Human0.92856048
95P300_19829295_ChIP-Seq_ESCs_Human0.92658986
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92498467
97RNF2_27304074_Chip-Seq_ESCs_Mouse0.92451574
98MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92301168
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92062636
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91575926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.33260798
2MP0008875_abnormal_xenobiotic_pharmacok4.83387290
3MP0001984_abnormal_olfaction3.71551853
4MP0004133_heterotaxia3.68560033
5MP0004043_abnormal_pH_regulation3.53140923
6MP0009780_abnormal_chondrocyte_physiolo2.96510940
7MP0008789_abnormal_olfactory_epithelium2.86672906
8MP0002132_abnormal_respiratory_system2.84982350
9MP0002277_abnormal_respiratory_mucosa2.40608162
10MP0009046_muscle_twitch2.25063061
11MP0005394_taste/olfaction_phenotype2.21698532
12MP0005499_abnormal_olfactory_system2.21698532
13MP0002734_abnormal_mechanical_nocicepti2.10351996
14MP0002909_abnormal_adrenal_gland2.04298290
15MP0005646_abnormal_pituitary_gland2.02375873
16MP0005377_hearing/vestibular/ear_phenot1.97038850
17MP0003878_abnormal_ear_physiology1.97038850
18MP0009745_abnormal_behavioral_response1.92169236
19MP0004859_abnormal_synaptic_plasticity1.90549431
20MP0005551_abnormal_eye_electrophysiolog1.77509884
21MP0002638_abnormal_pupillary_reflex1.75433918
22MP0001486_abnormal_startle_reflex1.71626507
23MP0002272_abnormal_nervous_system1.66337530
24MP0002735_abnormal_chemical_nociception1.63372709
25MP0002064_seizures1.60429441
26MP0001485_abnormal_pinna_reflex1.55122974
27MP0005645_abnormal_hypothalamus_physiol1.53461963
28MP0003880_abnormal_central_pattern1.53369764
29MP0005253_abnormal_eye_physiology1.51765314
30MP0004885_abnormal_endolymph1.50103530
31MP0002160_abnormal_reproductive_system1.47460419
32MP0001970_abnormal_pain_threshold1.47250326
33MP0002822_catalepsy1.46851133
34MP0008872_abnormal_physiological_respon1.46385718
35MP0004270_analgesia1.44368516
36MP0002572_abnormal_emotion/affect_behav1.40114055
37MP0000566_synostosis1.38370649
38MP0001765_abnormal_ion_homeostasis1.36381764
39MP0002557_abnormal_social/conspecific_i1.35742281
40MP0000383_abnormal_hair_follicle1.35584757
41MP0003635_abnormal_synaptic_transmissio1.35273202
42MP0002876_abnormal_thyroid_physiology1.32940853
43MP0001968_abnormal_touch/_nociception1.31193810
44MP0005083_abnormal_biliary_tract1.30902573
45MP0004142_abnormal_muscle_tone1.28731040
46MP0004019_abnormal_vitamin_homeostasis1.28624161
47MP0002168_other_aberrant_phenotype1.23569585
48MP0001188_hyperpigmentation1.22919862
49MP0002063_abnormal_learning/memory/cond1.19335661
50MP0006072_abnormal_retinal_apoptosis1.15774290
51MP0010386_abnormal_urinary_bladder1.15033553
52MP0000631_abnormal_neuroendocrine_gland1.12685929
53MP0005623_abnormal_meninges_morphology1.08685968
54MP0006276_abnormal_autonomic_nervous1.07474337
55MP0001529_abnormal_vocalization1.07201894
56MP0001905_abnormal_dopamine_level1.05404936
57MP0005220_abnormal_exocrine_pancreas1.04357418
58MP0001501_abnormal_sleep_pattern1.04266346
59MP0005636_abnormal_mineral_homeostasis1.02391522
60MP0002229_neurodegeneration1.01869130
61MP0003787_abnormal_imprinting1.01667845
62MP0002067_abnormal_sensory_capabilities0.99227883
63MP0002733_abnormal_thermal_nociception0.98930534
64MP0001963_abnormal_hearing_physiology0.98759713
65MP0001502_abnormal_circadian_rhythm0.96365575
66MP0010678_abnormal_skin_adnexa0.96095680
67MP0003866_abnormal_defecation0.95095549
68MP0005167_abnormal_blood-brain_barrier0.93571383
69MP0000955_abnormal_spinal_cord0.93304310
70MP0005389_reproductive_system_phenotype0.90565447
71MP0000026_abnormal_inner_ear0.89719731
72MP0002882_abnormal_neuron_morphology0.89063869
73MP0001944_abnormal_pancreas_morphology0.87719636
74MP0002928_abnormal_bile_duct0.85617601
75MP0005423_abnormal_somatic_nervous0.84951190
76MP0003633_abnormal_nervous_system0.84819436
77MP0003698_abnormal_male_reproductive0.83496014
78MP0002752_abnormal_somatic_nervous0.80348445
79MP0005365_abnormal_bile_salt0.78050848
80MP0003195_calcinosis0.77375314
81MP0005386_behavior/neurological_phenoty0.77344945
82MP0004924_abnormal_behavior0.77344945
83MP0001664_abnormal_digestion0.77020757
84MP0002282_abnormal_trachea_morphology0.75343079
85MP0002736_abnormal_nociception_after0.75236509
86MP0005085_abnormal_gallbladder_physiolo0.75059391
87MP0001270_distended_abdomen0.73724566
88MP0005195_abnormal_posterior_eye0.73290371
89MP0002069_abnormal_eating/drinking_beha0.71446689
90MP0005395_other_phenotype0.71102043
91MP0002066_abnormal_motor_capabilities/c0.71090915
92MP0000681_abnormal_thyroid_gland0.70394065
93MP0001986_abnormal_taste_sensitivity0.66134241
94MP0008961_abnormal_basal_metabolism0.65041958
95MP0001929_abnormal_gametogenesis0.64384335
96MP0000778_abnormal_nervous_system0.63383513
97MP0003136_yellow_coat_color0.63348339
98MP0002152_abnormal_brain_morphology0.63256097
99MP0004147_increased_porphyrin_level0.62879291
100MP0002233_abnormal_nose_morphology0.62243640

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.89448573
2Rhinitis (HP:0012384)9.17356370
3Chronic bronchitis (HP:0004469)7.30455982
4Bronchiectasis (HP:0002110)6.82676338
5Nasal polyposis (HP:0100582)5.84101198
6Abnormality of the nasal mucosa (HP:0000433)4.81277129
7Pancreatic fibrosis (HP:0100732)4.05101731
8Recurrent sinusitis (HP:0011108)4.01913706
9Bronchitis (HP:0012387)3.94035663
10True hermaphroditism (HP:0010459)3.90137129
11Infertility (HP:0000789)3.84373135
12Chronic sinusitis (HP:0011109)3.76236647
13Occipital encephalocele (HP:0002085)3.65864859
14Pancreatic cysts (HP:0001737)3.56366517
15Molar tooth sign on MRI (HP:0002419)3.43794198
16Abnormality of midbrain morphology (HP:0002418)3.43794198
17Nephronophthisis (HP:0000090)3.39611668
18Recurrent otitis media (HP:0000403)3.37067006
19Cystic liver disease (HP:0006706)3.31677616
20Male infertility (HP:0003251)3.13298984
21Chronic hepatic failure (HP:0100626)3.00151869
22Chronic otitis media (HP:0000389)2.92132814
23Atelectasis (HP:0100750)2.89999487
24Medial flaring of the eyebrow (HP:0010747)2.78884978
25Hyperactive renin-angiotensin system (HP:0000841)2.78206450
26Abnormality of the renal medulla (HP:0100957)2.76110201
27Postaxial foot polydactyly (HP:0001830)2.60341837
28Tubulointerstitial nephritis (HP:0001970)2.56648554
29Gait imbalance (HP:0002141)2.55928989
30Congenital primary aphakia (HP:0007707)2.47846562
31Congenital hepatic fibrosis (HP:0002612)2.44462475
32Anencephaly (HP:0002323)2.32803957
33Nephrogenic diabetes insipidus (HP:0009806)2.20683482
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.13109401
35Tubular atrophy (HP:0000092)2.03179858
36Sclerocornea (HP:0000647)2.02854326
37Male pseudohermaphroditism (HP:0000037)2.01586471
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4999599
39Abnormal respiratory epithelium morphology (HP:0012253)10.4162748
40Abnormal respiratory motile cilium morphology (HP:0005938)10.4162748
41Abnormal respiratory motile cilium physiology (HP:0012261)10.1230037
42Dynein arm defect of respiratory motile cilia (HP:0012255)10.1148230
43Absent/shortened dynein arms (HP:0200106)10.1148230
44Renal salt wasting (HP:0000127)1.96931351
45Aplasia/Hypoplasia of the spleen (HP:0010451)1.96520389
46Decreased circulating renin level (HP:0003351)1.96352364
47Asplenia (HP:0001746)1.90769041
48Postaxial hand polydactyly (HP:0001162)1.88321943
49Hyperaldosteronism (HP:0000859)1.86156904
50Furrowed tongue (HP:0000221)1.83135429
51Genital tract atresia (HP:0001827)1.75987972
52Vaginal atresia (HP:0000148)1.75049706
53Poor coordination (HP:0002370)1.71979871
54Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71771492
55Oculomotor apraxia (HP:0000657)1.71180332
56Hyperkalemia (HP:0002153)1.70155380
57Absent speech (HP:0001344)1.66781163
58Decreased central vision (HP:0007663)1.66593862
59Abnormality of renin-angiotensin system (HP:0000847)1.65767937
60Nephropathy (HP:0000112)1.65027559
61Abnormality of the renal cortex (HP:0011035)1.64019869
62Abnormal drinking behavior (HP:0030082)1.62788927
63Polydipsia (HP:0001959)1.62788927
64Recurrent bronchitis (HP:0002837)1.62746694
65Bell-shaped thorax (HP:0001591)1.58942714
66Preaxial hand polydactyly (HP:0001177)1.56807472
67Abnormality of chloride homeostasis (HP:0011422)1.54772648
68Tubulointerstitial abnormality (HP:0001969)1.51752844
69Hypokalemic alkalosis (HP:0001949)1.49302581
70Abnormal rod and cone electroretinograms (HP:0008323)1.42979878
71Retinitis pigmentosa (HP:0000510)1.42198236
72Bile duct proliferation (HP:0001408)1.40982471
73Abnormal biliary tract physiology (HP:0012439)1.40982471
74Disproportionate short-trunk short stature (HP:0003521)1.39718278
75Median cleft lip (HP:0000161)1.34635621
76Fetal akinesia sequence (HP:0001989)1.32076303
77Short thorax (HP:0010306)1.30537359
78Hyperventilation (HP:0002883)1.21266372
79Stage 5 chronic kidney disease (HP:0003774)1.20337516
80Spinal muscular atrophy (HP:0007269)1.20326241
81Broad-based gait (HP:0002136)1.20211214
82Specific learning disability (HP:0001328)1.19168563
83Supernumerary spleens (HP:0009799)1.18715147
84Polyuria (HP:0000103)1.17750087
85Narrow forehead (HP:0000341)1.16323015
86Aplasia/Hypoplasia of the lens (HP:0008063)1.13876734
87Multicystic kidney dysplasia (HP:0000003)1.13399018
88Hand muscle atrophy (HP:0009130)1.12839438
89Hip dysplasia (HP:0001385)1.12005612
90Aganglionic megacolon (HP:0002251)1.10936027
91Broad foot (HP:0001769)1.09448780
92Abnormality of macular pigmentation (HP:0008002)1.09389895
93Gaze-evoked nystagmus (HP:0000640)1.08851534
94Prominent nasal bridge (HP:0000426)1.07586058
95Cone-rod dystrophy (HP:0000548)1.07421621
96Left ventricular hypertrophy (HP:0001712)1.07378852
97Anosmia (HP:0000458)1.07239986
98Congenital stationary night blindness (HP:0007642)1.07095824
99Progressive cerebellar ataxia (HP:0002073)1.05048997
100Hyponatremia (HP:0002902)1.04847663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.17690756
2MST44.16144872
3FRK2.99364207
4EPHA22.62307743
5MAP4K22.37463690
6INSRR2.34938221
7NME12.29930457
8BCR1.94967187
9MAPKAPK31.92870180
10MAP3K41.92642767
11PTK2B1.77090064
12MAPK131.54917010
13GRK11.48891407
14CAMKK11.45123282
15ADRBK21.44233595
16DAPK21.40888790
17WNK31.38724765
18MAP2K71.37500902
19PINK11.37271314
20CASK1.34704278
21WNK41.33388918
22BMPR1B1.30309611
23EPHA41.28370603
24NTRK31.16172563
25MARK11.07918376
26TLK11.07504633
27ACVR1B1.05327272
28CSK1.02449638
29MAP3K70.97827654
30UHMK10.97794801
31PRKCI0.96052169
32ERBB20.94379801
33SIK20.94047225
34ERBB30.93402686
35DYRK20.91839957
36MARK20.88420792
37PAK30.87288397
38ADRBK10.85133589
39FER0.85064176
40PRKCQ0.84193594
41NEK60.82712958
42OXSR10.82700229
43PRKD30.81402503
44STK380.78686227
45TNK20.77795349
46NTRK20.76217067
47STK390.72364057
48TIE10.71803339
49STK240.71309249
50PHKG10.69621393
51PHKG20.69621393
52LMTK20.68615119
53PRKCE0.68449729
54PLK20.67229051
55CAMK2G0.65934804
56PRKCG0.65856278
57IRAK10.63252911
58CAMK2A0.62414843
59EPHA30.61150225
60MAP3K20.61073055
61PRKCH0.59238399
62MINK10.58751243
63TRIM280.58534051
64PAK60.57511546
65MAP2K40.54666981
66STK110.54206127
67SGK10.51429846
68SGK2230.50134559
69SGK4940.50134559
70DYRK1A0.50073556
71PRKCZ0.49798173
72PRKACA0.49000369
73DYRK1B0.47692864
74PKN10.47597085
75CAMKK20.47096492
76CDK50.47083207
77TAOK30.46314786
78PRKCA0.45556779
79EPHB10.45377416
80PRKAA20.43223388
81CSNK1G20.42564812
82FGFR20.40691151
83CAMK10.40402287
84DAPK10.39432495
85LRRK20.38832807
86PRKCD0.38791902
87CCNB10.36401278
88FES0.35981987
89BCKDK0.34748165
90TRPM70.32177208
91PRKAA10.31772048
92MAP2K60.31072944
93HIPK20.30486185
94CSNK1A10.29611388
95ABL10.27981669
96TESK10.26864991
97PRKG10.26310332
98ITK0.25454951
99STK38L0.25311259
100CSNK1A1L0.24304744

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.09462759
2Histidine metabolism_Homo sapiens_hsa003403.51634371
3Chemical carcinogenesis_Homo sapiens_hsa052043.51271382
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.36891149
5Phenylalanine metabolism_Homo sapiens_hsa003602.99548751
6beta-Alanine metabolism_Homo sapiens_hsa004102.69130546
7Linoleic acid metabolism_Homo sapiens_hsa005912.49417973
8Nicotine addiction_Homo sapiens_hsa050332.47837527
9Tyrosine metabolism_Homo sapiens_hsa003502.46556849
10Huntingtons disease_Homo sapiens_hsa050162.18195032
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04453266
12Retinol metabolism_Homo sapiens_hsa008301.87911689
13Phototransduction_Homo sapiens_hsa047441.86881483
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84165575
15Caffeine metabolism_Homo sapiens_hsa002321.82631022
16Glutathione metabolism_Homo sapiens_hsa004801.62190711
17ABC transporters_Homo sapiens_hsa020101.59520986
18Peroxisome_Homo sapiens_hsa041461.54107660
19Salivary secretion_Homo sapiens_hsa049701.53248721
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53233346
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50746524
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46037194
23Taste transduction_Homo sapiens_hsa047421.45346351
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40997250
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.39249604
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37235201
27Butanoate metabolism_Homo sapiens_hsa006501.32096145
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30823049
29Synaptic vesicle cycle_Homo sapiens_hsa047211.26682788
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.26476048
31Sphingolipid metabolism_Homo sapiens_hsa006001.25194575
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24017186
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19080740
34Collecting duct acid secretion_Homo sapiens_hsa049661.18561446
35Insulin secretion_Homo sapiens_hsa049111.18286450
36Olfactory transduction_Homo sapiens_hsa047401.17914278
37Arachidonic acid metabolism_Homo sapiens_hsa005901.15737184
38Glutamatergic synapse_Homo sapiens_hsa047241.15412004
39Circadian entrainment_Homo sapiens_hsa047131.07498351
40GABAergic synapse_Homo sapiens_hsa047271.05704134
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.05617097
42Ether lipid metabolism_Homo sapiens_hsa005651.01411365
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97775127
44Regulation of autophagy_Homo sapiens_hsa041400.97765659
45Fatty acid degradation_Homo sapiens_hsa000710.96501942
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95028514
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94973177
48Cocaine addiction_Homo sapiens_hsa050300.94065965
49Nitrogen metabolism_Homo sapiens_hsa009100.93081590
50Serotonergic synapse_Homo sapiens_hsa047260.92768178
51Morphine addiction_Homo sapiens_hsa050320.92718460
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.88667000
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84637866
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84051588
55Amphetamine addiction_Homo sapiens_hsa050310.81663135
56Notch signaling pathway_Homo sapiens_hsa043300.80067611
57Type I diabetes mellitus_Homo sapiens_hsa049400.78891577
58Tight junction_Homo sapiens_hsa045300.77863593
59Calcium signaling pathway_Homo sapiens_hsa040200.75082161
60Cardiac muscle contraction_Homo sapiens_hsa042600.73328311
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.71992997
62Circadian rhythm_Homo sapiens_hsa047100.70978953
63Dopaminergic synapse_Homo sapiens_hsa047280.70959638
64cAMP signaling pathway_Homo sapiens_hsa040240.70690167
65Gastric acid secretion_Homo sapiens_hsa049710.68693995
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65736493
67Tryptophan metabolism_Homo sapiens_hsa003800.65340817
68Arginine and proline metabolism_Homo sapiens_hsa003300.63993869
69Oxidative phosphorylation_Homo sapiens_hsa001900.58657872
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57649189
71Ovarian steroidogenesis_Homo sapiens_hsa049130.57491446
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52510732
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.51831532
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50083234
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49365639
76Cholinergic synapse_Homo sapiens_hsa047250.48873804
77Pancreatic secretion_Homo sapiens_hsa049720.48138491
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47079117
79Oxytocin signaling pathway_Homo sapiens_hsa049210.46429958
80Choline metabolism in cancer_Homo sapiens_hsa052310.46322975
81Metabolic pathways_Homo sapiens_hsa011000.43324103
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42089082
83Glycerolipid metabolism_Homo sapiens_hsa005610.41146769
84Bile secretion_Homo sapiens_hsa049760.41113283
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40396405
86Autoimmune thyroid disease_Homo sapiens_hsa053200.35964281
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.35308523
88Allograft rejection_Homo sapiens_hsa053300.35219546
89Mineral absorption_Homo sapiens_hsa049780.34642499
90Propanoate metabolism_Homo sapiens_hsa006400.34128977
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.31787450
92Graft-versus-host disease_Homo sapiens_hsa053320.31352403
93Asthma_Homo sapiens_hsa053100.30002832
94Long-term depression_Homo sapiens_hsa047300.29277243
95Axon guidance_Homo sapiens_hsa043600.29211367
96Hedgehog signaling pathway_Homo sapiens_hsa043400.28449636
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27634632
98Starch and sucrose metabolism_Homo sapiens_hsa005000.26774199
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25211722
100Parkinsons disease_Homo sapiens_hsa050120.23825201

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