KIF1BP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.84897542
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.71578454
3locomotory exploration behavior (GO:0035641)5.47356298
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19820056
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.02323213
6synaptic vesicle exocytosis (GO:0016079)4.94542525
7glutamate secretion (GO:0014047)4.93369155
8regulation of synaptic vesicle exocytosis (GO:2000300)4.81776921
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.60106501
10vocalization behavior (GO:0071625)4.56965495
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51039251
12regulation of synaptic vesicle transport (GO:1902803)4.32920042
13regulation of neuronal synaptic plasticity (GO:0048168)4.31166689
14regulation of glutamate receptor signaling pathway (GO:1900449)4.28613449
15neuronal action potential propagation (GO:0019227)4.25418243
16exploration behavior (GO:0035640)4.24882601
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.18146356
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16485412
19protein localization to synapse (GO:0035418)4.12686425
20neuron cell-cell adhesion (GO:0007158)4.06491059
21neurotransmitter secretion (GO:0007269)4.00487526
22cellular potassium ion homeostasis (GO:0030007)3.98239897
23layer formation in cerebral cortex (GO:0021819)3.95744200
24regulation of synapse structural plasticity (GO:0051823)3.92716375
25sodium ion export (GO:0071436)3.82683583
26dendritic spine morphogenesis (GO:0060997)3.71516465
27synaptic transmission, glutamatergic (GO:0035249)3.70601831
28glutamate receptor signaling pathway (GO:0007215)3.68556639
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67160092
30long-term memory (GO:0007616)3.66245262
31gamma-aminobutyric acid transport (GO:0015812)3.59824892
32proline transport (GO:0015824)3.54324137
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53451567
34neuron-neuron synaptic transmission (GO:0007270)3.51170700
35neurotransmitter-gated ion channel clustering (GO:0072578)3.47649814
36regulation of synaptic plasticity (GO:0048167)3.44898944
37positive regulation of membrane potential (GO:0045838)3.39955606
38neuron recognition (GO:0008038)3.39575191
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38234043
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37949965
41transmission of nerve impulse (GO:0019226)3.37368474
42activation of protein kinase A activity (GO:0034199)3.37239089
43neurotransmitter transport (GO:0006836)3.34058268
44long-term synaptic potentiation (GO:0060291)3.33701196
45L-amino acid import (GO:0043092)3.30165105
46neuromuscular process controlling balance (GO:0050885)3.29976436
47glycine transport (GO:0015816)3.29762296
48synaptic vesicle endocytosis (GO:0048488)3.28629912
49axonal fasciculation (GO:0007413)3.23653630
50regulation of postsynaptic membrane potential (GO:0060078)3.23407858
51regulation of dendritic spine morphogenesis (GO:0061001)3.23251486
52regulation of neurotransmitter secretion (GO:0046928)3.22226134
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21480092
54positive regulation of synapse maturation (GO:0090129)3.20194420
55cell communication by electrical coupling (GO:0010644)3.18702508
56dendrite morphogenesis (GO:0048813)3.15145023
57potassium ion import (GO:0010107)3.13726577
58neuronal ion channel clustering (GO:0045161)3.11922228
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10670749
60neuromuscular process controlling posture (GO:0050884)3.09271678
61cerebellar Purkinje cell differentiation (GO:0021702)3.08485971
62vesicle transport along microtubule (GO:0047496)3.08062064
63regulation of neurotransmitter levels (GO:0001505)3.06924870
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.04364548
65cullin deneddylation (GO:0010388)3.04342428
66positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00603265
67protein deneddylation (GO:0000338)3.00588958
68negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99923023
69regulation of neurotransmitter transport (GO:0051588)2.99000405
70regulation of synaptic transmission, glutamatergic (GO:0051966)2.95690304
71regulation of vesicle fusion (GO:0031338)2.94681821
72membrane depolarization during action potential (GO:0086010)2.94317384
73membrane hyperpolarization (GO:0060081)2.90522559
74dendritic spine organization (GO:0097061)2.89605286
75regulation of ARF protein signal transduction (GO:0032012)2.88837511
76adult walking behavior (GO:0007628)2.88192736
77innervation (GO:0060384)2.87205251
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.86754600
79mating behavior (GO:0007617)2.86476105
80membrane depolarization (GO:0051899)2.85985259
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85488781
82positive regulation of mitochondrial fission (GO:0090141)2.85368117
83response to auditory stimulus (GO:0010996)2.84793584
84regulation of voltage-gated calcium channel activity (GO:1901385)2.83553888
85potassium ion homeostasis (GO:0055075)2.82947658
86cerebellar granule cell differentiation (GO:0021707)2.82775282
87regulation of synaptic transmission (GO:0050804)2.82631267
88positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82220613
89pyrimidine nucleobase catabolic process (GO:0006208)2.80892406
90positive regulation of neurotransmitter secretion (GO:0001956)2.79742083
91organelle transport along microtubule (GO:0072384)2.79704475
92positive regulation of synaptic transmission (GO:0050806)2.79080319
93prepulse inhibition (GO:0060134)2.78773795
94neuromuscular process (GO:0050905)2.78073659
95positive regulation of potassium ion transmembrane transport (GO:1901381)2.77479789
96positive regulation of neurotransmitter transport (GO:0051590)2.77326274
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77190827
98chemosensory behavior (GO:0007635)2.76170313
99regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75989882
100learning (GO:0007612)2.75681178
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75633816
102cerebellar Purkinje cell layer development (GO:0021680)2.75295154
103cellular sodium ion homeostasis (GO:0006883)2.73982359
104regulation of dendritic spine development (GO:0060998)2.73465352
105proteasome assembly (GO:0043248)2.73263270
106L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47649466
107ubiquinone metabolic process (GO:0006743)2.47506306
108nonmotile primary cilium assembly (GO:0035058)2.45503098
109intraciliary transport (GO:0042073)2.44485777
110DNA damage response, detection of DNA damage (GO:0042769)2.42801288
111regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42242272
112presynaptic membrane assembly (GO:0097105)2.40072213
113regulation of meiosis I (GO:0060631)2.38126841
114piRNA metabolic process (GO:0034587)2.37815579
115nucleobase catabolic process (GO:0046113)2.36657723
116establishment of integrated proviral latency (GO:0075713)2.35902238
117ribonucleoprotein complex disassembly (GO:0032988)2.35805070
118protein polyglutamylation (GO:0018095)2.31756284
119postsynaptic membrane organization (GO:0001941)2.31436727
120establishment of mitochondrion localization (GO:0051654)2.28547599
121cholesterol biosynthetic process (GO:0006695)2.28268516
122chromatin remodeling at centromere (GO:0031055)2.27443084
123CENP-A containing nucleosome assembly (GO:0034080)2.25512499
124anterograde axon cargo transport (GO:0008089)2.24166184
125presynaptic membrane organization (GO:0097090)2.22727093
126positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.21833392
127ubiquinone biosynthetic process (GO:0006744)2.17005251
128mitotic spindle organization (GO:0007052)2.16224661
129de novo protein folding (GO:0006458)2.13932450
130de novo posttranslational protein folding (GO:0051084)2.12798466
131sterol biosynthetic process (GO:0016126)2.12342278
132cytoskeleton-dependent intracellular transport (GO:0030705)2.11876289
133negative regulation of meiosis (GO:0045835)2.08531995
134establishment of viral latency (GO:0019043)2.08195757
135synapsis (GO:0007129)2.07806582
136peptidyl-cysteine modification (GO:0018198)2.06454707
137regulation of coenzyme metabolic process (GO:0051196)2.06100130
138regulation of cofactor metabolic process (GO:0051193)2.06100130
139organelle disassembly (GO:1903008)2.04906790
140microtubule-based transport (GO:0010970)2.03788162
141histone exchange (GO:0043486)2.03582301
142regulation of DNA endoreduplication (GO:0032875)2.01816807
143protein K11-linked ubiquitination (GO:0070979)2.01483508
144L-serine metabolic process (GO:0006563)2.01443141
145hippocampus development (GO:0021766)2.00581205
146DNA replication-dependent nucleosome assembly (GO:0006335)2.00188550
147DNA replication-dependent nucleosome organization (GO:0034723)2.00188550
148ventricular cardiac muscle cell development (GO:0055015)1.99031048
149axon cargo transport (GO:0008088)1.97390035
150iron-sulfur cluster assembly (GO:0016226)1.97291602
151metallo-sulfur cluster assembly (GO:0031163)1.97291602
152regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)1.96696232
153histone H2A acetylation (GO:0043968)1.96621009
154negative regulation of oligodendrocyte differentiation (GO:0048715)1.96460520
155COPI coating of Golgi vesicle (GO:0048205)1.95321628
156Golgi transport vesicle coating (GO:0048200)1.95321628
157regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)1.94338343
158lipopolysaccharide biosynthetic process (GO:0009103)1.93841184
159fatty acid elongation (GO:0030497)1.93552887
160anterograde synaptic vesicle transport (GO:0048490)1.93451271
161anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:01.93378657
162righting reflex (GO:0060013)1.93059354
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)1.92566128
164mitochondrial respiratory chain complex I assembly (GO:0032981)1.92566128
165NADH dehydrogenase complex assembly (GO:0010257)1.92566128
166aspartate family amino acid catabolic process (GO:0009068)1.91787297
167lipid particle organization (GO:0034389)1.91303050
168L-methionine salvage (GO:0071267)1.91251435
169L-methionine biosynthetic process (GO:0071265)1.91251435
170amino acid salvage (GO:0043102)1.91251435
171regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)1.89584301
172metaphase plate congression (GO:0051310)1.88871780
173DNA methylation involved in gamete generation (GO:0043046)1.88081571
174retinal ganglion cell axon guidance (GO:0031290)1.87279254
175mitotic metaphase plate congression (GO:0007080)1.87044774
176negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)1.86268732
177cilium morphogenesis (GO:0060271)1.85923570
178negative regulation of DNA recombination (GO:0045910)1.85848987
179calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)1.85844813
180pyrimidine dimer repair (GO:0006290)1.84547944
181behavioral response to nicotine (GO:0035095)1.84303302
182protein refolding (GO:0042026)1.83743908
183olfactory bulb development (GO:0021772)1.83476657
184ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043161.83473887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52676656
2GBX2_23144817_ChIP-Seq_PC3_Human3.12106452
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94381363
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91854333
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84904754
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84375137
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62573395
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62573395
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.61815252
10REST_21632747_ChIP-Seq_MESCs_Mouse2.56579746
11DROSHA_22980978_ChIP-Seq_HELA_Human2.54550990
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51331552
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48958789
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46078316
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42716692
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37667450
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36661731
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33898560
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.25765594
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.19533598
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17833249
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.17080849
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.12640230
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.11474937
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.10062329
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08320941
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06776774
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06303506
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03173251
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.00558801
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97509814
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86268945
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85916310
34AR_21572438_ChIP-Seq_LNCaP_Human1.83152947
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83004976
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81117458
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80906120
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80272883
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79209643
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74915978
41ELK1_19687146_ChIP-ChIP_HELA_Human1.71726795
42FUS_26573619_Chip-Seq_HEK293_Human1.65114887
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.56461504
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54728502
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.54142306
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52955346
47SMAD4_21799915_ChIP-Seq_A2780_Human1.52335293
48EWS_26573619_Chip-Seq_HEK293_Human1.51245482
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49213599
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48757748
51AR_21909140_ChIP-Seq_LNCAP_Human1.43001499
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.42141649
53DCP1A_22483619_ChIP-Seq_HELA_Human1.38691032
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38644366
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38569796
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38438113
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33825293
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33562876
59CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.32096496
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31002070
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30337784
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30191851
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30016476
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.28969760
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28797302
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28559896
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28527558
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27806926
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27790898
70ZNF274_21170338_ChIP-Seq_K562_Hela1.27194713
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26358932
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.26125717
73GABP_19822575_ChIP-Seq_HepG2_Human1.24936970
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24709642
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24515132
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24041429
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23642531
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22655937
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21917379
80NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21776907
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21073749
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20460019
83STAT3_23295773_ChIP-Seq_U87_Human1.20395401
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19398603
85AR_19668381_ChIP-Seq_PC3_Human1.19077588
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18837316
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.18532133
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18338926
89TAF15_26573619_Chip-Seq_HEK293_Human1.18224246
90P300_19829295_ChIP-Seq_ESCs_Human1.17783712
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17714291
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14995601
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13980352
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13671682
95KDM2B_26808549_Chip-Seq_K562_Human1.13598792
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12858545
97AR_25329375_ChIP-Seq_VCAP_Human1.12353351
98MYC_18940864_ChIP-ChIP_HL60_Human1.12140863
99MYC_18555785_ChIP-Seq_MESCs_Mouse1.11534837
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11341123
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10617661
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09037633
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08983757
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08580781
105CBX2_27304074_Chip-Seq_ESCs_Mouse1.07779685
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07497893
107TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07359791
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06973396
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.06942396
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06669255
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05885483
112RING1B_27294783_Chip-Seq_NPCs_Mouse1.05854206
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05618534
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04648965
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04542488
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03059514
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02575912
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02230779
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.02219305
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02126137
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.02052562
122TCF4_23295773_ChIP-Seq_U87_Human1.01308052
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01197259
124YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00876447
125SMAD3_21741376_ChIP-Seq_ESCs_Human1.00315481
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00177378
127IGF1R_20145208_ChIP-Seq_DFB_Human1.00032566
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99502051
129VDR_23849224_ChIP-Seq_CD4+_Human0.99376063
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.99228346
131JUN_21703547_ChIP-Seq_K562_Human0.99071562
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98774415
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97913913
134SOX9_26525672_Chip-Seq_HEART_Mouse0.97738583
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.97561147
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97491315
137AHR_22903824_ChIP-Seq_MCF-7_Human0.96911780
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96828676
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96794421
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96602111
141FLI1_27457419_Chip-Seq_LIVER_Mouse0.96351948
142FOXM1_23109430_ChIP-Seq_U2OS_Human0.96224098
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.96051228
144TP53_22573176_ChIP-Seq_HFKS_Human0.95948259
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.94550937
146SRF_21415370_ChIP-Seq_HL-1_Mouse0.94475601
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.94211187
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92949177
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92866573
150TP53_16413492_ChIP-PET_HCT116_Human0.91392718
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.91333585
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91149959
153ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90444577
154RXR_22108803_ChIP-Seq_LS180_Human0.89871287
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89259378
156REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88798880
157PRDM14_20953172_ChIP-Seq_ESCs_Human0.88752549
158RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88735951
159TTF2_22483619_ChIP-Seq_HELA_Human0.88064694
160PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86246802
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86231213
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86009430
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.85264124
164RUNX2_22187159_ChIP-Seq_PCA_Human0.85119150
165RNF2_27304074_Chip-Seq_NSC_Mouse0.84392023
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83974699
167TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83107820
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.82348488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.41562696
2MP0003880_abnormal_central_pattern4.49503138
3MP0003635_abnormal_synaptic_transmissio4.02057515
4MP0004270_analgesia3.88431203
5MP0009745_abnormal_behavioral_response3.19810034
6MP0002063_abnormal_learning/memory/cond3.16023281
7MP0002064_seizures3.12641056
8MP0002822_catalepsy2.90183927
9MP0009046_muscle_twitch2.89261117
10MP0005423_abnormal_somatic_nervous2.79225577
11MP0002272_abnormal_nervous_system2.65323139
12MP0002572_abnormal_emotion/affect_behav2.61953541
13MP0001968_abnormal_touch/_nociception2.57097156
14MP0002734_abnormal_mechanical_nocicepti2.54381320
15MP0001486_abnormal_startle_reflex2.50862683
16MP0002102_abnormal_ear_morphology2.30404886
17MP0003329_amyloid_beta_deposits2.12777842
18MP0009780_abnormal_chondrocyte_physiolo2.08832375
19MP0008877_abnormal_DNA_methylation2.07127626
20MP0001440_abnormal_grooming_behavior2.03855725
21MP0001501_abnormal_sleep_pattern2.03591769
22MP0004885_abnormal_endolymph2.00106846
23MP0008569_lethality_at_weaning1.98451762
24MP0002736_abnormal_nociception_after1.95877378
25MP0002735_abnormal_chemical_nociception1.95123295
26MP0002733_abnormal_thermal_nociception1.93174507
27MP0008789_abnormal_olfactory_epithelium1.92197642
28MP0001970_abnormal_pain_threshold1.90341975
29MP0004858_abnormal_nervous_system1.88558890
30MP0002909_abnormal_adrenal_gland1.86276937
31MP0000778_abnormal_nervous_system1.85627751
32MP0002067_abnormal_sensory_capabilities1.82095700
33MP0001984_abnormal_olfaction1.79376280
34MP0004811_abnormal_neuron_physiology1.73172221
35MP0005386_behavior/neurological_phenoty1.71445776
36MP0004924_abnormal_behavior1.71445776
37MP0008058_abnormal_DNA_repair1.67182330
38MP0002557_abnormal_social/conspecific_i1.62305429
39MP0005646_abnormal_pituitary_gland1.60645454
40MP0002184_abnormal_innervation1.59744788
41MP0000955_abnormal_spinal_cord1.59508579
42MP0003633_abnormal_nervous_system1.55036219
43MP0000920_abnormal_myelination1.50284003
44MP0002882_abnormal_neuron_morphology1.48076366
45MP0005645_abnormal_hypothalamus_physiol1.45159630
46MP0002066_abnormal_motor_capabilities/c1.44478129
47MP0010030_abnormal_orbit_morphology1.37912057
48MP0002234_abnormal_pharynx_morphology1.34844978
49MP0004145_abnormal_muscle_electrophysio1.31888006
50MP0003690_abnormal_glial_cell1.31793250
51MP0003937_abnormal_limbs/digits/tail_de1.31658693
52MP0006276_abnormal_autonomic_nervous1.31156456
53MP0003941_abnormal_skin_development1.30935406
54MP0003631_nervous_system_phenotype1.30677763
55MP0008932_abnormal_embryonic_tissue1.29408745
56MP0003879_abnormal_hair_cell1.28548690
57MP0003787_abnormal_imprinting1.25184790
58MP0001502_abnormal_circadian_rhythm1.24116451
59MP0004142_abnormal_muscle_tone1.23637372
60MP0005187_abnormal_penis_morphology1.23354145
61MP0002638_abnormal_pupillary_reflex1.23080815
62MP0000751_myopathy1.22872640
63MP0001905_abnormal_dopamine_level1.21238294
64MP0003634_abnormal_glial_cell1.20007241
65MP0001529_abnormal_vocalization1.19431634
66MP0002233_abnormal_nose_morphology1.19381896
67MP0002229_neurodegeneration1.18104098
68MP0002160_abnormal_reproductive_system1.16695580
69MP0003693_abnormal_embryo_hatching1.16606930
70MP0000749_muscle_degeneration1.15260773
71MP0000647_abnormal_sebaceous_gland1.13852638
72MP0000049_abnormal_middle_ear1.13834462
73MP0003121_genomic_imprinting1.12677914
74MP0002152_abnormal_brain_morphology1.11602589
75MP0004742_abnormal_vestibular_system1.10571282
76MP0003122_maternal_imprinting1.07608795
77MP0005551_abnormal_eye_electrophysiolog1.06813907
78MP0003890_abnormal_embryonic-extraembry1.04513225
79MP0003075_altered_response_to1.04209923
80MP0010094_abnormal_chromosome_stability1.03470231
81MP0000013_abnormal_adipose_tissue1.03018090
82MP0003755_abnormal_palate_morphology1.02898249
83MP0003283_abnormal_digestive_organ1.01426953
84MP0000537_abnormal_urethra_morphology1.01130452
85MP0003119_abnormal_digestive_system1.00532490
86MP0001293_anophthalmia0.99486996
87MP0003718_maternal_effect0.98378357
88MP0003632_abnormal_nervous_system0.97599945
89MP0003136_yellow_coat_color0.97091060
90MP0004043_abnormal_pH_regulation0.96155933
91MP0002938_white_spotting0.95129495
92MP0005167_abnormal_blood-brain_barrier0.94911598
93MP0001346_abnormal_lacrimal_gland0.94492087
94MP0003011_delayed_dark_adaptation0.94315541
95MP0001177_atelectasis0.92911997
96MP0003123_paternal_imprinting0.92692840
97MP0008007_abnormal_cellular_replicative0.92231003
98MP0003111_abnormal_nucleus_morphology0.91801584
99MP0003861_abnormal_nervous_system0.91675831
100MP0005253_abnormal_eye_physiology0.91463305
101MP0005623_abnormal_meninges_morphology0.91229952
102MP0000604_amyloidosis0.90650440
103MP0002837_dystrophic_cardiac_calcinosis0.90427342
104MP0002069_abnormal_eating/drinking_beha0.89469590
105MP0001485_abnormal_pinna_reflex0.87989518
106MP0003221_abnormal_cardiomyocyte_apopto0.87326197
107MP0004215_abnormal_myocardial_fiber0.85704995
108MP0004085_abnormal_heartbeat0.85499254
109MP0006292_abnormal_olfactory_placode0.84275045
110MP0003077_abnormal_cell_cycle0.84147787
111MP0000427_abnormal_hair_cycle0.83917558
112MP0005248_abnormal_Harderian_gland0.83377048
113MP0008872_abnormal_physiological_respon0.82445857
114MP0001963_abnormal_hearing_physiology0.82362778
115MP0008874_decreased_physiological_sensi0.82149637
116MP0002210_abnormal_sex_determination0.82084661
117MP0002751_abnormal_autonomic_nervous0.80457747
118MP0005535_abnormal_body_temperature0.79781397
119MP0000747_muscle_weakness0.79167065
120MP0006035_abnormal_mitochondrial_morpho0.79146065
121MP0002084_abnormal_developmental_patter0.79043159
122MP0002177_abnormal_outer_ear0.78824555
123MP0002752_abnormal_somatic_nervous0.78526476
124MP0001299_abnormal_eye_distance/0.77842395
125MP0002090_abnormal_vision0.76750716
126MP0004484_altered_response_of0.75699597
127MP0005410_abnormal_fertilization0.75631242
128MP0003172_abnormal_lysosome_physiology0.75208327
129MP0003385_abnormal_body_wall0.74865999
130MP0010386_abnormal_urinary_bladder0.74173549
131MP0002697_abnormal_eye_size0.73342787
132MP0004957_abnormal_blastocyst_morpholog0.73179478
133MP0002269_muscular_atrophy0.72612758
134MP0008961_abnormal_basal_metabolism0.72079533
135MP0002282_abnormal_trachea_morphology0.71895583
136MP0000762_abnormal_tongue_morphology0.70888990
137MP0004233_abnormal_muscle_weight0.69184705
138MP0003137_abnormal_impulse_conducting0.69110320
139MP0005394_taste/olfaction_phenotype0.66219577
140MP0005499_abnormal_olfactory_system0.66219577
141MP0006072_abnormal_retinal_apoptosis0.62064191
142MP0004130_abnormal_muscle_cell0.60726669
143MP0000631_abnormal_neuroendocrine_gland0.59900474
144MP0001188_hyperpigmentation0.57447894
145MP0000569_abnormal_digit_pigmentation0.56332362
146MP0004510_myositis0.54544373
147MP0001943_abnormal_respiration0.54425396
148MP0004036_abnormal_muscle_relaxation0.54027386
149MP0002653_abnormal_ependyma_morphology0.53283290
150MP0000003_abnormal_adipose_tissue0.53221543

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.46646459
2Myokymia (HP:0002411)6.38392014
3Focal seizures (HP:0007359)5.13472775
4Visual hallucinations (HP:0002367)4.89768025
5Action tremor (HP:0002345)4.34476245
6Epileptic encephalopathy (HP:0200134)4.22700557
7Atonic seizures (HP:0010819)4.09748902
8Supranuclear gaze palsy (HP:0000605)3.97809059
9Progressive cerebellar ataxia (HP:0002073)3.86959220
10Ankle clonus (HP:0011448)3.56157683
11Absence seizures (HP:0002121)3.49101719
12Febrile seizures (HP:0002373)3.47386722
13Generalized tonic-clonic seizures (HP:0002069)3.37659301
14Dysmetria (HP:0001310)3.36980554
15Depression (HP:0000716)3.26097302
16Postural instability (HP:0002172)3.23443705
17Dialeptic seizures (HP:0011146)3.22823632
18Neurofibrillary tangles (HP:0002185)3.22482366
19Broad-based gait (HP:0002136)3.11857094
20Intention tremor (HP:0002080)3.06991113
21Dysdiadochokinesis (HP:0002075)3.06171942
22Poor eye contact (HP:0000817)3.03140828
23Abnormality of the labia minora (HP:0012880)2.97904612
24Impaired vibration sensation in the lower limbs (HP:0002166)2.97273363
25Cerebral inclusion bodies (HP:0100314)2.97269248
26Mutism (HP:0002300)2.92899935
27Anxiety (HP:0000739)2.90055128
28Cortical dysplasia (HP:0002539)2.88989330
29Urinary urgency (HP:0000012)2.88925789
30Pheochromocytoma (HP:0002666)2.87638044
31Truncal ataxia (HP:0002078)2.79730142
32Papilledema (HP:0001085)2.78982125
33Impaired social interactions (HP:0000735)2.78534306
34Abnormal social behavior (HP:0012433)2.78534306
35Spastic gait (HP:0002064)2.78519620
36Gaze-evoked nystagmus (HP:0000640)2.78279061
37Megalencephaly (HP:0001355)2.77365674
38Urinary bladder sphincter dysfunction (HP:0002839)2.73149603
39Abnormal eating behavior (HP:0100738)2.69008041
40Termporal pattern (HP:0011008)2.65189897
41Insidious onset (HP:0003587)2.65189897
42Scanning speech (HP:0002168)2.60633418
43Hyperventilation (HP:0002883)2.56550372
44Torticollis (HP:0000473)2.56522249
45Amblyopia (HP:0000646)2.56101682
46Abnormality of the corticospinal tract (HP:0002492)2.54692501
47Ventricular fibrillation (HP:0001663)2.52591372
48Gait imbalance (HP:0002141)2.50799919
49Genetic anticipation (HP:0003743)2.49069948
50Neuroendocrine neoplasm (HP:0100634)2.48625847
51Medial flaring of the eyebrow (HP:0010747)2.40701641
52Bradykinesia (HP:0002067)2.40676600
53Congenital primary aphakia (HP:0007707)2.37579371
54Focal dystonia (HP:0004373)2.37320003
55Lower limb muscle weakness (HP:0007340)2.37198465
56Shoulder girdle muscle weakness (HP:0003547)2.35137545
57Progressive inability to walk (HP:0002505)2.31788913
58Increased serum pyruvate (HP:0003542)2.31211506
59Fetal akinesia sequence (HP:0001989)2.30043213
60Drooling (HP:0002307)2.29558730
61Excessive salivation (HP:0003781)2.29558730
62Abnormality of the lower motor neuron (HP:0002366)2.28328436
63Limb dystonia (HP:0002451)2.28303817
64Impaired smooth pursuit (HP:0007772)2.25568935
65Abnormality of glycolysis (HP:0004366)2.23559880
66Epileptiform EEG discharges (HP:0011182)2.23329705
67Abnormality of binocular vision (HP:0011514)2.21068678
68Diplopia (HP:0000651)2.21068678
69Split foot (HP:0001839)2.20847643
70Hand muscle atrophy (HP:0009130)2.20546491
71Bundle branch block (HP:0011710)2.20075401
72Hemiparesis (HP:0001269)2.20005456
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.19381111
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19381111
75Peripheral hypomyelination (HP:0007182)2.18765291
76EEG with generalized epileptiform discharges (HP:0011198)2.18182200
77Nephrogenic diabetes insipidus (HP:0009806)2.17738895
78Insomnia (HP:0100785)2.16001407
79Type II lissencephaly (HP:0007260)2.15317220
80Stereotypic behavior (HP:0000733)2.12665266
81Hypsarrhythmia (HP:0002521)2.12382998
82Craniofacial dystonia (HP:0012179)2.09014795
83Short tibia (HP:0005736)2.06402992
84Exercise-induced muscle cramps (HP:0003710)2.06282639
85Abnormality of ocular smooth pursuit (HP:0000617)2.04152964
86Rapidly progressive (HP:0003678)2.02578243
87Hemiplegia (HP:0002301)2.02025036
88Lissencephaly (HP:0001339)2.02011713
89Absent speech (HP:0001344)2.01469754
90Rigidity (HP:0002063)2.00906165
91Gait ataxia (HP:0002066)2.00841556
92Generalized myoclonic seizures (HP:0002123)1.97358749
93Neuronal loss in central nervous system (HP:0002529)1.97272150
94Limb-girdle muscle atrophy (HP:0003797)1.96770825
95Abnormality of the musculature of the pelvis (HP:0001469)1.95612574
96Abnormality of the hip-girdle musculature (HP:0001445)1.95612574
97Genital tract atresia (HP:0001827)1.95423008
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.94527176
99Abnormality of alanine metabolism (HP:0010916)1.93353952
100Hyperalaninemia (HP:0003348)1.93353952
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93353952
102Clonus (HP:0002169)1.93195041
103Vaginal atresia (HP:0000148)1.92866305
104Abnormal protein glycosylation (HP:0012346)1.92654650
105Abnormal glycosylation (HP:0012345)1.92654650
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92654650
107Abnormal protein N-linked glycosylation (HP:0012347)1.92654650
108Impaired vibratory sensation (HP:0002495)1.92579575
109Retinal dysplasia (HP:0007973)1.91512186
110Neoplasm of the peripheral nervous system (HP:0100007)1.91481530
111Agitation (HP:0000713)1.89422755
112Dysmetric saccades (HP:0000641)1.89149841
113True hermaphroditism (HP:0010459)1.89140617
114Status epilepticus (HP:0002133)1.88608909
115Hypoglycemic seizures (HP:0002173)1.87347218
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87269655
117Aplasia/Hypoplasia of the tibia (HP:0005772)1.86767689
118Abnormality of saccadic eye movements (HP:0000570)1.85594294
119Abnormal EKG (HP:0003115)1.83060635
120Acute necrotizing encephalopathy (HP:0006965)1.82361045
121Lower limb asymmetry (HP:0100559)1.82100976
122Oligodactyly (hands) (HP:0001180)1.81838268
123Delayed gross motor development (HP:0002194)1.81650060
124Incomplete penetrance (HP:0003829)1.81454646
125Occipital encephalocele (HP:0002085)1.80521180
126Obstructive sleep apnea (HP:0002870)1.79877336
127Macroorchidism (HP:0000053)1.78873543
128Pointed chin (HP:0000307)1.78509579
129Annular pancreas (HP:0001734)1.77875087
130Increased circulating renin level (HP:0000848)1.77259732
131Cerebral hypomyelination (HP:0006808)1.76322298
132Polyphagia (HP:0002591)1.76112813
133Postural tremor (HP:0002174)1.75579578
134Blue irides (HP:0000635)1.74812145
135Hypoglycemic coma (HP:0001325)1.74780546
136Prolonged QT interval (HP:0001657)1.74230749
137Specific learning disability (HP:0001328)1.74147826
138Aplasia involving bones of the extremities (HP:0009825)1.73305296
139Aplasia of the phalanges of the hand (HP:0009802)1.73305296
140Limb-girdle muscle weakness (HP:0003325)1.73140573
141Abnormality of the metopic suture (HP:0005556)1.72282614
142Abnormality of the anterior horn cell (HP:0006802)1.72152096
143Degeneration of anterior horn cells (HP:0002398)1.72152096
144Postaxial hand polydactyly (HP:0001162)1.71969262
145Pachygyria (HP:0001302)1.71688412
146Preaxial hand polydactyly (HP:0001177)1.71677675
147Abnormal mitochondria in muscle tissue (HP:0008316)1.71379941
148Rimmed vacuoles (HP:0003805)1.71223131
149Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70727627
150Amyotrophic lateral sclerosis (HP:0007354)1.70232517
151Acute encephalopathy (HP:0006846)1.68991429
152Inability to walk (HP:0002540)1.67891064
153Poor suck (HP:0002033)1.66897213
154Prominent metopic ridge (HP:0005487)1.64412873
155Supernumerary spleens (HP:0009799)1.63779557
156Pancreatic fibrosis (HP:0100732)1.62894259
157Abnormality of midbrain morphology (HP:0002418)1.62292734
158Molar tooth sign on MRI (HP:0002419)1.62292734
159Postnatal microcephaly (HP:0005484)1.61071486
160Astrocytoma (HP:0009592)1.60802459
161Abnormality of the astrocytes (HP:0100707)1.60802459
162Poor coordination (HP:0002370)1.60181941
163Papillary thyroid carcinoma (HP:0002895)1.59670103
164Pancreatic cysts (HP:0001737)1.59409204
165CNS hypomyelination (HP:0003429)1.57805748
166Fibular aplasia (HP:0002990)1.57459421
167Type I transferrin isoform profile (HP:0003642)1.56376227
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.55239989
169Colon cancer (HP:0003003)1.55125545
170Hepatoblastoma (HP:0002884)1.53145056
171Oligodactyly (HP:0012165)1.52975772
172Cerebellar dysplasia (HP:0007033)1.52895063
173Methylmalonic acidemia (HP:0002912)1.52745960
174Hyperinsulinemic hypoglycemia (HP:0000825)1.52160785
175Sclerocornea (HP:0000647)1.51774354
176Medulloblastoma (HP:0002885)1.51546627
177Upper limb amyotrophy (HP:0009129)1.50275372
178Distal upper limb amyotrophy (HP:0007149)1.50275372
179Spastic tetraplegia (HP:0002510)1.49026401
180Broad foot (HP:0001769)1.48736167
181Bifid tongue (HP:0010297)1.48486966
182Hypokinesia (HP:0002375)1.47035537
183Abnormal lung lobation (HP:0002101)1.43897022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.14053137
2EPHA43.94573160
3MAP3K93.54880566
4MAP3K42.87494524
5TRIM282.68163166
6KSR22.57516131
7LIMK12.53819962
8MARK12.51259852
9MINK12.51202646
10PRKD32.49445095
11BCR2.37252941
12PAK62.35670226
13SRPK12.24855512
14DAPK22.21351747
15NEK12.14400339
16TSSK62.13870132
17MAP2K72.06309384
18NTRK12.04368310
19BUB12.02138882
20PBK1.90630947
21CAMKK11.83474915
22CSNK1G31.72180480
23NTRK21.70768779
24CSNK1A1L1.68127532
25TESK11.67128802
26MAP2K41.65969777
27CSNK1G11.63312214
28WEE11.61277156
29MAP3K21.57792706
30PNCK1.57533566
31MET1.55640858
32CDK51.55057407
33ARAF1.54099039
34RIPK41.54023959
35KSR11.49882348
36MAP3K121.46667158
37CDC71.45290713
38PRPF4B1.44380199
39TTK1.43968218
40TYRO31.40965452
41MAP4K21.40864477
42STK381.39501393
43EIF2AK31.38372329
44PHKG11.37993364
45PHKG21.37993364
46CDK191.35776413
47OXSR11.30304414
48ERBB31.30194954
49GRK51.27922600
50PLK21.27418933
51UHMK11.27352252
52TNIK1.23568876
53PLK31.22393109
54SGK2231.20386255
55SGK4941.20386255
56PLK11.19945008
57PINK11.15992182
58STK391.15614405
59CASK1.14924945
60FES1.14851931
61PRKCG1.10487587
62MAP3K131.09608954
63STK38L1.09094389
64DAPK11.08795778
65MAPK131.05957571
66CAMKK21.04899254
67LMTK21.04396107
68DYRK21.04220247
69BCKDK1.04091432
70RET1.03478305
71WNK11.03381218
72BRSK11.02236015
73CAMK2A0.99734175
74PIM20.98348361
75PRKCH0.98020688
76DMPK0.94447980
77CAMK2B0.92573124
78PAK30.91219636
79CDK150.90089657
80CDK140.89830350
81CDK180.89599344
82PDK10.89089555
83RAF10.88730078
84STK110.88369140
85SIK20.87106798
86CCNB10.86212980
87PDPK10.84891848
88PTK2B0.84097859
89CAMK10.82213557
90NEK60.81922556
91MAPKAPK50.81297057
92ZAK0.80565371
93PLK40.80419844
94CDK11A0.77774961
95CAMK2D0.75572416
96MAP3K10.74398902
97ALK0.74275274
98WNK40.72771959
99AURKA0.72563532
100TAOK10.71967122
101LATS20.71726393
102SGK30.70609199
103CAMK1G0.70507524
104PTK20.70325666
105CSNK1G20.69615158
106BMPR20.68827505
107SGK20.67603388
108VRK20.66832804
109SGK10.63973330
110BRAF0.63061269
111EPHB20.62555508
112STK160.61556518
113ROCK20.61254283
114MARK20.61028588
115LATS10.60900305
116CAMK2G0.60771399
117EIF2AK10.60021052
118MST40.59401170
119BMPR1B0.58610359
120DYRK30.58197063
121PKN10.57678288
122ERBB40.56348432
123FGFR20.54586557
124DYRK1A0.53570088
125VRK10.53189686
126MKNK20.52328941
127MAP2K10.51851281
128CSNK1E0.50865331
129PRKCE0.50587637
130RIPK10.49588348
131BRSK20.47588149
132RPS6KA30.47040371
133ABL20.46765072
134NUAK10.46490050
135FYN0.46193424
136TNK20.45900389
137MAPK100.45728595
138ATM0.45386063
139PRKCZ0.44971270
140OBSCN0.44769018
141AURKB0.44549442
142CHEK20.44342414
143ATR0.42885898
144NEK90.42731756
145MAP3K70.42438364
146FGR0.40392262
147FER0.40364533
148ICK0.39752315
149DAPK30.39525604
150PDK30.37087401
151PDK40.37087401
152WNK30.35711867
153CDC42BPA0.34300533

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.10072233
2Nicotine addiction_Homo sapiens_hsa050333.03862042
3Olfactory transduction_Homo sapiens_hsa047402.76213677
4Long-term potentiation_Homo sapiens_hsa047202.55942656
5Circadian entrainment_Homo sapiens_hsa047132.55328512
6GABAergic synapse_Homo sapiens_hsa047272.49025432
7Glutamatergic synapse_Homo sapiens_hsa047242.41789691
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40602305
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33522673
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.32990406
11Amphetamine addiction_Homo sapiens_hsa050312.31146377
12Morphine addiction_Homo sapiens_hsa050322.26799282
13Protein export_Homo sapiens_hsa030602.26328173
14Salivary secretion_Homo sapiens_hsa049702.14789350
15Steroid biosynthesis_Homo sapiens_hsa001002.07606152
16Dopaminergic synapse_Homo sapiens_hsa047282.06799706
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04523505
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02661604
19Proteasome_Homo sapiens_hsa030502.01107194
20Insulin secretion_Homo sapiens_hsa049111.99580177
21Gastric acid secretion_Homo sapiens_hsa049711.95215102
22Cholinergic synapse_Homo sapiens_hsa047251.90124189
23Fatty acid elongation_Homo sapiens_hsa000621.79727447
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71555074
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71058716
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69763636
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66936383
28Propanoate metabolism_Homo sapiens_hsa006401.64555999
29Long-term depression_Homo sapiens_hsa047301.63258752
30Renin secretion_Homo sapiens_hsa049241.61936316
31Cocaine addiction_Homo sapiens_hsa050301.61513875
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61303633
33Mismatch repair_Homo sapiens_hsa034301.59446054
34Oxytocin signaling pathway_Homo sapiens_hsa049211.56763713
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55736325
36Serotonergic synapse_Homo sapiens_hsa047261.54636465
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54269352
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53498972
39Taste transduction_Homo sapiens_hsa047421.52005310
40Oxidative phosphorylation_Homo sapiens_hsa001901.47203736
41Basal transcription factors_Homo sapiens_hsa030221.45901405
42Nitrogen metabolism_Homo sapiens_hsa009101.44855059
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44775280
44Calcium signaling pathway_Homo sapiens_hsa040201.44674379
45GnRH signaling pathway_Homo sapiens_hsa049121.39743433
46Parkinsons disease_Homo sapiens_hsa050121.39385197
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34862400
48Collecting duct acid secretion_Homo sapiens_hsa049661.33619600
49Gap junction_Homo sapiens_hsa045401.32908900
50RNA polymerase_Homo sapiens_hsa030201.32602351
51cAMP signaling pathway_Homo sapiens_hsa040241.27275269
52Butanoate metabolism_Homo sapiens_hsa006501.25387437
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23397660
54Base excision repair_Homo sapiens_hsa034101.21877389
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21802380
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21642893
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20625963
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20097576
59RNA transport_Homo sapiens_hsa030131.19662903
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.19612638
61Pyruvate metabolism_Homo sapiens_hsa006201.18568594
62Type II diabetes mellitus_Homo sapiens_hsa049301.18422651
63Estrogen signaling pathway_Homo sapiens_hsa049151.17879911
64DNA replication_Homo sapiens_hsa030301.16581769
65Glioma_Homo sapiens_hsa052141.15644243
66Folate biosynthesis_Homo sapiens_hsa007901.14531357
67Nucleotide excision repair_Homo sapiens_hsa034201.14331590
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13453812
69Axon guidance_Homo sapiens_hsa043601.12082844
70Huntingtons disease_Homo sapiens_hsa050161.09406713
71cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09274286
72Sulfur relay system_Homo sapiens_hsa041221.07293972
73Fanconi anemia pathway_Homo sapiens_hsa034601.06812434
74Vitamin B6 metabolism_Homo sapiens_hsa007501.05832385
75RNA degradation_Homo sapiens_hsa030181.05250532
76Dorso-ventral axis formation_Homo sapiens_hsa043201.03172634
77ErbB signaling pathway_Homo sapiens_hsa040121.02664401
78Biosynthesis of amino acids_Homo sapiens_hsa012301.01305839
79Carbon metabolism_Homo sapiens_hsa012001.00256687
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99859008
81Cell cycle_Homo sapiens_hsa041100.99082956
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98820765
83Melanogenesis_Homo sapiens_hsa049160.98786978
84Vibrio cholerae infection_Homo sapiens_hsa051100.97862046
85Selenocompound metabolism_Homo sapiens_hsa004500.97817944
86Phototransduction_Homo sapiens_hsa047440.97025416
87Pancreatic secretion_Homo sapiens_hsa049720.96826086
88Regulation of autophagy_Homo sapiens_hsa041400.95503885
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.95139114
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95122947
91Fatty acid metabolism_Homo sapiens_hsa012120.93718555
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.93337908
93Cardiac muscle contraction_Homo sapiens_hsa042600.93079530
94Arginine and proline metabolism_Homo sapiens_hsa003300.92517924
95Homologous recombination_Homo sapiens_hsa034400.92296007
96Hippo signaling pathway_Homo sapiens_hsa043900.92130619
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90525610
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87968335
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86436243
100Oocyte meiosis_Homo sapiens_hsa041140.84844631
101Thyroid hormone synthesis_Homo sapiens_hsa049180.83573485
102Non-homologous end-joining_Homo sapiens_hsa034500.81730080
103Pyrimidine metabolism_Homo sapiens_hsa002400.78661458
104Choline metabolism in cancer_Homo sapiens_hsa052310.78439445
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77216043
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76930068
107Dilated cardiomyopathy_Homo sapiens_hsa054140.74789919
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72501542
109Purine metabolism_Homo sapiens_hsa002300.72020952
110Peroxisome_Homo sapiens_hsa041460.71898391
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70675532
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70428740
113VEGF signaling pathway_Homo sapiens_hsa043700.69273542
114Spliceosome_Homo sapiens_hsa030400.67792914
115MAPK signaling pathway_Homo sapiens_hsa040100.67029025
116Endocytosis_Homo sapiens_hsa041440.66960706
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66937524
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.66392485
119Hedgehog signaling pathway_Homo sapiens_hsa043400.66197581
120mRNA surveillance pathway_Homo sapiens_hsa030150.64028633
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.63556127
122Ras signaling pathway_Homo sapiens_hsa040140.61433809
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60906319
124N-Glycan biosynthesis_Homo sapiens_hsa005100.60226075
125Glucagon signaling pathway_Homo sapiens_hsa049220.59573348
126Inositol phosphate metabolism_Homo sapiens_hsa005620.58558327
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57852679
128Prion diseases_Homo sapiens_hsa050200.57353522
129Metabolic pathways_Homo sapiens_hsa011000.56742552
130Renal cell carcinoma_Homo sapiens_hsa052110.56675661
131beta-Alanine metabolism_Homo sapiens_hsa004100.55465893
132p53 signaling pathway_Homo sapiens_hsa041150.55387516
133Sulfur metabolism_Homo sapiens_hsa009200.53711087
134Rap1 signaling pathway_Homo sapiens_hsa040150.53035478
135mTOR signaling pathway_Homo sapiens_hsa041500.51682552
136Bile secretion_Homo sapiens_hsa049760.50633786
137Basal cell carcinoma_Homo sapiens_hsa052170.49228858
138Alcoholism_Homo sapiens_hsa050340.47284132
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.47242551
140Endometrial cancer_Homo sapiens_hsa052130.46124932
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44347304
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44025790
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43883307
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42453185
145Non-small cell lung cancer_Homo sapiens_hsa052230.41777140
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40686664
147Type I diabetes mellitus_Homo sapiens_hsa049400.40626176
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40583575
149Insulin signaling pathway_Homo sapiens_hsa049100.40491252
150Ovarian steroidogenesis_Homo sapiens_hsa049130.39714511
151Circadian rhythm_Homo sapiens_hsa047100.39661008
152Wnt signaling pathway_Homo sapiens_hsa043100.38380151
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37448230
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37323889
155TGF-beta signaling pathway_Homo sapiens_hsa043500.37203440
156Chemokine signaling pathway_Homo sapiens_hsa040620.35611745
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.35258798
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34444963
159Tight junction_Homo sapiens_hsa045300.34434363
160Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34302965
161Mineral absorption_Homo sapiens_hsa049780.33540852
162Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31503464
163Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30900904
164Alzheimers disease_Homo sapiens_hsa050100.28541041
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27492669

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