KIF1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)4.57829630
2carnitine shuttle (GO:0006853)4.56336375
3plasma membrane repair (GO:0001778)4.48758522
4fatty acid transmembrane transport (GO:1902001)4.48751895
5lysine catabolic process (GO:0006554)4.30491153
6lysine metabolic process (GO:0006553)4.30491153
7actin-myosin filament sliding (GO:0033275)4.18789726
8muscle filament sliding (GO:0030049)4.18789726
92-oxoglutarate metabolic process (GO:0006103)4.01916979
10regulation of skeletal muscle contraction (GO:0014819)3.98368487
11focal adhesion assembly (GO:0048041)3.96815809
12cell-substrate adherens junction assembly (GO:0007045)3.96815809
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.94660676
14cell-substrate junction assembly (GO:0007044)3.94458738
15bundle of His cell to Purkinje myocyte communication (GO:0086069)3.92770048
16response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.92231451
17hemidesmosome assembly (GO:0031581)3.90967482
18cardiac myofibril assembly (GO:0055003)3.87818714
19skeletal muscle contraction (GO:0003009)3.80345943
20adherens junction assembly (GO:0034333)3.80199760
21regulation of sequestering of triglyceride (GO:0010889)3.76168517
22positive regulation of fatty acid beta-oxidation (GO:0032000)3.75230161
23fatty acid beta-oxidation (GO:0006635)3.75089409
24myofibril assembly (GO:0030239)3.70852392
25alpha-linolenic acid metabolic process (GO:0036109)3.58726320
26tricarboxylic acid cycle (GO:0006099)3.58111765
27actin-mediated cell contraction (GO:0070252)3.52701787
28carnitine transmembrane transport (GO:1902603)3.52385410
29aspartate family amino acid catabolic process (GO:0009068)3.52309044
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.51379073
31positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.50560242
32regulation of fatty acid oxidation (GO:0046320)3.48796859
33cytoskeletal anchoring at plasma membrane (GO:0007016)3.44698015
34positive regulation of fatty acid oxidation (GO:0046321)3.42580134
35amino-acid betaine transport (GO:0015838)3.41554028
36carnitine transport (GO:0015879)3.41554028
37negative regulation of potassium ion transmembrane transport (GO:1901380)3.39768881
38fatty acid oxidation (GO:0019395)3.36937608
39acetyl-CoA metabolic process (GO:0006084)3.34598013
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33805777
41L-phenylalanine metabolic process (GO:0006558)3.33659827
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.33659827
43regulation of fatty acid beta-oxidation (GO:0031998)3.30796456
44lipid oxidation (GO:0034440)3.30535306
45L-phenylalanine catabolic process (GO:0006559)3.28896546
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28896546
47response to muscle activity (GO:0014850)3.27634752
48regulation of triglyceride catabolic process (GO:0010896)3.25721138
49fatty acid catabolic process (GO:0009062)3.25295029
50regulation of the force of heart contraction (GO:0002026)3.23790211
51glyoxylate metabolic process (GO:0046487)3.22563208
52regulation of actin filament-based movement (GO:1903115)3.21823407
53kynurenine metabolic process (GO:0070189)3.20007785
54amino-acid betaine metabolic process (GO:0006577)3.20004301
55epithelial cell-cell adhesion (GO:0090136)3.14982341
56cardiac muscle contraction (GO:0060048)3.12268879
57regulation of relaxation of muscle (GO:1901077)3.12244810
58actomyosin structure organization (GO:0031032)3.12111191
59ventricular cardiac muscle cell action potential (GO:0086005)3.11821656
60sulfur amino acid catabolic process (GO:0000098)3.10139680
61muscle contraction (GO:0006936)3.09639306
62desmosome organization (GO:0002934)3.08233975
63low-density lipoprotein particle clearance (GO:0034383)3.07947284
64negative regulation of fibrinolysis (GO:0051918)3.07672232
65carnitine metabolic process (GO:0009437)3.07299698
66creatine metabolic process (GO:0006600)3.05167941
67cardiac muscle hypertrophy (GO:0003300)3.04995584
68valine metabolic process (GO:0006573)3.04186684
69phospholipid homeostasis (GO:0055091)3.04011495
70short-chain fatty acid metabolic process (GO:0046459)3.04003720
71regulation of cholesterol homeostasis (GO:2000188)3.03700454
72cellular ketone body metabolic process (GO:0046950)2.98654717
73dicarboxylic acid biosynthetic process (GO:0043650)2.98516370
74monocarboxylic acid catabolic process (GO:0072329)2.97997463
75tricarboxylic acid metabolic process (GO:0072350)2.96283249
76positive regulation of lipid catabolic process (GO:0050996)2.95725816
77actin filament-based movement (GO:0030048)2.95369310
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95104752
79striated muscle hypertrophy (GO:0014897)2.91982570
80cysteine metabolic process (GO:0006534)2.91948991
81regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.90315244
82regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.89929778
83ethanol oxidation (GO:0006069)2.89527070
84plasma lipoprotein particle clearance (GO:0034381)2.89370351
85cardiac muscle cell development (GO:0055013)2.87624407
86biotin metabolic process (GO:0006768)2.84281997
87oxaloacetate metabolic process (GO:0006107)2.83742709
88protein carboxylation (GO:0018214)2.82794216
89peptidyl-glutamic acid carboxylation (GO:0017187)2.82794216
90cardiac muscle tissue morphogenesis (GO:0055008)2.82607973
91regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81364753
92cell communication by electrical coupling (GO:0010644)2.81023958
93NADH metabolic process (GO:0006734)2.80438377
944-hydroxyproline metabolic process (GO:0019471)2.80295713
95aromatic amino acid family catabolic process (GO:0009074)2.79080554
96muscle tissue morphogenesis (GO:0060415)2.78777904
97regulation of cell communication by electrical coupling (GO:0010649)2.77885365
98complement activation, alternative pathway (GO:0006957)2.77539248
99striated muscle contraction (GO:0006941)2.76678020
100quaternary ammonium group transport (GO:0015697)2.74466468
101glycogen catabolic process (GO:0005980)2.74432188
102muscle system process (GO:0003012)2.74238242
103homocysteine metabolic process (GO:0050667)2.74162053
104protein localization to endosome (GO:0036010)2.73330884
105cardiac cell development (GO:0055006)2.72306852
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71869780
107skeletal muscle fiber development (GO:0048741)2.70478025
108basement membrane organization (GO:0071711)2.69283023
109regulation of fibrinolysis (GO:0051917)2.67870678
110sarcoplasmic reticulum calcium ion transport (GO:0070296)2.67824766
111skeletal muscle adaptation (GO:0043501)2.66452832
112cell communication involved in cardiac conduction (GO:0086065)2.65460971
113positive regulation of triglyceride metabolic process (GO:0090208)2.65165005
114glucan catabolic process (GO:0009251)2.65089631
115regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64731193
116negative regulation of cell size (GO:0045792)2.64678995
117regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64383438
118regulation of early endosome to late endosome transport (GO:2000641)2.64362091
119fatty acid homeostasis (GO:0055089)2.64335195
120intracellular lipid transport (GO:0032365)2.63618523
121cellular modified amino acid catabolic process (GO:0042219)2.63488432
122striated muscle adaptation (GO:0014888)2.62908377
123heart trabecula formation (GO:0060347)2.61382464
124regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.61217399
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.61214125
126bile acid biosynthetic process (GO:0006699)2.60852067
127regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.59714219
128negative regulation of fatty acid transport (GO:2000192)2.58836428
129regulation of protein activation cascade (GO:2000257)2.58667533
130regulation of p38MAPK cascade (GO:1900744)2.58403792
131triglyceride homeostasis (GO:0070328)2.58147002
132acylglycerol homeostasis (GO:0055090)2.58147002
133response to mercury ion (GO:0046689)2.56837520
134negative regulation of protein localization to cell surface (GO:2000009)2.56482896
135muscle hypertrophy (GO:0014896)2.53032722
136gap junction assembly (GO:0016264)2.52674336
137barbed-end actin filament capping (GO:0051016)2.50748003
138positive regulation of myotube differentiation (GO:0010831)2.50679840
139positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.49564174
140response to inactivity (GO:0014854)2.49066212
141striated muscle atrophy (GO:0014891)2.48784692
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.48550845
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.47963954
144sodium ion export (GO:0071436)2.45273053
145ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.45108993
146stress fiber assembly (GO:0043149)2.43789297
147skin morphogenesis (GO:0043589)2.39093939
148cardiac muscle adaptation (GO:0014887)2.37962658
149cardiac muscle hypertrophy in response to stress (GO:0014898)2.37962658
150muscle hypertrophy in response to stress (GO:0003299)2.37962658
151atrioventricular valve morphogenesis (GO:0003181)2.36634112
152myoblast fusion (GO:0007520)2.36605391
153gluconeogenesis (GO:0006094)2.36515417
154endothelial cell morphogenesis (GO:0001886)2.34380824
155COPI coating of Golgi vesicle (GO:0048205)2.32204791
156Golgi transport vesicle coating (GO:0048200)2.32204791
157actin filament depolymerization (GO:0030042)2.30919994
158endodermal cell differentiation (GO:0035987)2.29561756
159cellular polysaccharide catabolic process (GO:0044247)2.28467366
160vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28054687
161syncytium formation by plasma membrane fusion (GO:0000768)2.27716799
162regulation of striated muscle contraction (GO:0006942)2.27606108
163regulation of cardioblast differentiation (GO:0051890)2.26489735
164positive regulation of receptor recycling (GO:0001921)2.26308860
165positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26233647
166regulation of tight junction assembly (GO:2000810)2.26116022
167protein targeting to plasma membrane (GO:0072661)2.24630141
168regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23328599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.76350000
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.64015124
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.15704614
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.84469150
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.78134187
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.59161646
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95246149
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90569677
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.82623778
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.67285197
11CLOCK_20551151_ChIP-Seq_293T_Human2.57772629
12ZNF263_19887448_ChIP-Seq_K562_Human2.27764015
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.23293610
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.15952672
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05576376
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.00431328
17* TBX20_22080862_ChIP-Seq_HEART_Mouse1.97919365
18* TBX20_22328084_ChIP-Seq_HEART_Mouse1.97919365
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93625280
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.92691693
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82248187
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78679939
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74514547
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70214230
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.66391373
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64651633
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.57183964
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57124308
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56374929
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53087875
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49311621
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48702941
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.44241964
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.43871400
35RACK7_27058665_Chip-Seq_MCF-7_Human1.41886180
36LXR_22292898_ChIP-Seq_THP-1_Human1.40554280
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38091199
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37861772
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36864339
40SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36396059
41TCF7_22412390_ChIP-Seq_EML_Mouse1.35701372
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35553830
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33868966
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32940961
45SMC4_20622854_ChIP-Seq_HELA_Human1.32722792
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31837090
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31584486
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29944931
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27497998
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.26687071
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26506137
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24727069
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.23455696
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22825072
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21864594
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21372014
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.21221953
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.20414702
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20010914
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19540267
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.17586275
62ATF3_27146783_Chip-Seq_COLON_Human1.17584987
63TP53_22127205_ChIP-Seq_IMR90_Human1.17498477
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17472263
65TET1_21490601_ChIP-Seq_MESCs_Mouse1.17076680
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16356683
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16032865
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15767383
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.15754006
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13329801
71* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12653986
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12210610
73P68_20966046_ChIP-Seq_HELA_Human1.11737837
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10647475
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08558219
76CJUN_26792858_Chip-Seq_BT549_Human1.08434683
77SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07639230
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.07161353
79* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05818813
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04614887
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04465534
82KDM2B_26808549_Chip-Seq_DND41_Human1.02940825
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02525714
84STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02282176
85KDM2B_26808549_Chip-Seq_K562_Human1.01883230
86* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99950827
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99863971
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99863971
89SA1_27219007_Chip-Seq_ERYTHROID_Human0.99783680
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99771684
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97787300
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97159303
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.96665076
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96440696
95CDX2_20551321_ChIP-Seq_CACO-2_Human0.95710928
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93782995
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93482603
98GATA4_25053715_ChIP-Seq_YYC3_Human0.93407618
99GATA1_19941826_ChIP-Seq_K562_Human0.92944363
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92076681
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91924260
102SOX2_20726797_ChIP-Seq_SW620_Human0.91754793
103CREB1_26743006_Chip-Seq_LNCaP_Human0.89849752
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89317687
105* TP63_22573176_ChIP-Seq_HFKS_Human0.89249048
106SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88898786
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88898786
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88726941
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87814480
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87121045
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86281842
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84722916
113GATA2_19941826_ChIP-Seq_K562_Human0.84313059
114HNF4A_19822575_ChIP-Seq_HepG2_Human0.83913628
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82981952
116GATA6_25053715_ChIP-Seq_YYC3_Human0.82883457
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82822034
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82070285
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81793916
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81270125
121GATA1_22025678_ChIP-Seq_K562_Human0.80102934
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79865950
123JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79576505
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79453525
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79088907
126GATA3_24758297_ChIP-Seq_MCF-7_Human0.78458934
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.78336378
128SMC1_22415368_ChIP-Seq_MEFs_Mouse0.77539350
129CTCF_27219007_Chip-Seq_Bcells_Human0.77477837
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76389782
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75757439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.22234769
2MP0000751_myopathy3.47806714
3MP0002139_abnormal_hepatobiliary_system3.41510328
4MP0005360_urolithiasis3.31863448
5MP0003705_abnormal_hypodermis_morpholog3.23373379
6MP0003646_muscle_fatigue3.21441865
7MP0004084_abnormal_cardiac_muscle2.99507226
8MP0005085_abnormal_gallbladder_physiolo2.70851393
9MP0004130_abnormal_muscle_cell2.70610745
10MP0000749_muscle_degeneration2.69797478
11MP0004036_abnormal_muscle_relaxation2.59142016
12MP0005365_abnormal_bile_salt2.46356899
13MP0005330_cardiomyopathy2.40702845
14MP0008438_abnormal_cutaneous_collagen2.33449765
15MP0005275_abnormal_skin_tensile2.32049601
16MP0004087_abnormal_muscle_fiber2.29772215
17MP0004215_abnormal_myocardial_fiber2.19971408
18MP0003252_abnormal_bile_duct2.04539991
19MP0005666_abnormal_adipose_tissue2.02925641
20MP0000750_abnormal_muscle_regeneration2.02452570
21MP0008875_abnormal_xenobiotic_pharmacok1.91308003
22MP0009840_abnormal_foam_cell1.88572312
23MP0004185_abnormal_adipocyte_glucose1.88416432
24MP0005670_abnormal_white_adipose1.87345534
25MP0010329_abnormal_lipoprotein_level1.85005777
26MP0005620_abnormal_muscle_contractility1.83140437
27MP0005409_darkened_coat_color1.81116696
28MP0002269_muscular_atrophy1.80631746
29MP0000747_muscle_weakness1.78271541
30MP0003806_abnormal_nucleotide_metabolis1.76047746
31MP0002972_abnormal_cardiac_muscle1.75680585
32MP0004145_abnormal_muscle_electrophysio1.69630084
33MP0002106_abnormal_muscle_physiology1.68094841
34MP0010630_abnormal_cardiac_muscle1.67267504
35MP0005083_abnormal_biliary_tract1.64443417
36MP0008775_abnormal_heart_ventricle1.62290395
37MP0003191_abnormal_cellular_cholesterol1.60914345
38MP0001544_abnormal_cardiovascular_syste1.58673052
39MP0005385_cardiovascular_system_phenoty1.58673052
40MP0000759_abnormal_skeletal_muscle1.57387186
41MP0006138_congestive_heart_failure1.55755480
42MP0002877_abnormal_melanocyte_morpholog1.53943818
43MP0003566_abnormal_cell_adhesion1.51682688
44MP0002796_impaired_skin_barrier1.49615597
45MP0001849_ear_inflammation1.46935362
46MP0005257_abnormal_intraocular_pressure1.46423107
47MP0005375_adipose_tissue_phenotype1.46163653
48MP0010234_abnormal_vibrissa_follicle1.45688804
49MP0004858_abnormal_nervous_system1.45637420
50MP0005332_abnormal_amino_acid1.41201459
51MP0005369_muscle_phenotype1.40323131
52MP0002118_abnormal_lipid_homeostasis1.32442651
53MP0003195_calcinosis1.31821416
54MP0000762_abnormal_tongue_morphology1.31484315
55MP0004272_abnormal_basement_membrane1.30922706
56MP0010368_abnormal_lymphatic_system1.30182541
57MP0003941_abnormal_skin_development1.29951837
58MP0003091_abnormal_cell_migration1.29733251
59MP0001666_abnormal_nutrient_absorption1.27009807
60MP0003137_abnormal_impulse_conducting1.24602189
61MP0004484_altered_response_of1.22166703
62MP0002971_abnormal_brown_adipose1.17862752
63MP0001661_extended_life_span1.17179889
64MP0005319_abnormal_enzyme/_coenzyme1.16921548
65MP0003279_aneurysm1.15835965
66MP0010030_abnormal_orbit_morphology1.14809974
67MP0000609_abnormal_liver_physiology1.11992356
68MP0000467_abnormal_esophagus_morphology1.09322685
69MP0002060_abnormal_skin_morphology1.06100051
70MP0002332_abnormal_exercise_endurance1.05762542
71MP0004233_abnormal_muscle_weight1.04924602
72MP0003828_pulmonary_edema1.04026658
73MP0005503_abnormal_tendon_morphology1.03223183
74MP0010352_gastrointestinal_tract_polyps1.02616878
75MP0001299_abnormal_eye_distance/1.01814223
76MP0003221_abnormal_cardiomyocyte_apopto1.01458552
77MP0000733_abnormal_muscle_development1.01312583
78MP0005451_abnormal_body_composition1.01011410
79MP0001958_emphysema1.00935427
80MP0006036_abnormal_mitochondrial_physio0.99677969
81MP0009384_cardiac_valve_regurgitation0.97880686
82MP0002127_abnormal_cardiovascular_syste0.97362567
83MP0005076_abnormal_cell_differentiation0.96875352
84MP0002108_abnormal_muscle_morphology0.96630308
85MP0000678_abnormal_parathyroid_gland0.95851526
86MP0005623_abnormal_meninges_morphology0.92664057
87MP0001348_abnormal_lacrimal_gland0.91653881
88MP0004270_analgesia0.91165541
89MP0000013_abnormal_adipose_tissue0.90135285
90MP0000579_abnormal_nail_morphology0.90073902
91MP0000003_abnormal_adipose_tissue0.89996383
92MP0004085_abnormal_heartbeat0.89056880
93MP0003300_gastrointestinal_ulcer0.86572512
94MP0005584_abnormal_enzyme/coenzyme_acti0.86296689
95MP0009643_abnormal_urine_homeostasis0.86162775
96MP0002254_reproductive_system_inflammat0.85224329
97MP0003950_abnormal_plasma_membrane0.84613249
98MP0005058_abnormal_lysosome_morphology0.84423155
99MP0002089_abnormal_postnatal_growth/wei0.83569183
100MP0002234_abnormal_pharynx_morphology0.83480527
101MP0000343_altered_response_to0.82515827
102MP0003329_amyloid_beta_deposits0.81631961
103MP0004510_myositis0.81391959
104MP0003879_abnormal_hair_cell0.79700052
105MP0005165_increased_susceptibility_to0.78695389
106MP0005167_abnormal_blood-brain_barrier0.78590133
107MP0002138_abnormal_hepatobiliary_system0.78076304
108MP0008961_abnormal_basal_metabolism0.77324217
109MP0000566_synostosis0.76178372
110MP0004019_abnormal_vitamin_homeostasis0.74624028
111MP0002249_abnormal_larynx_morphology0.74539894
112MP0005334_abnormal_fat_pad0.73388988
113MP0002128_abnormal_blood_circulation0.73215932
114MP0003045_fibrosis0.72894632
115MP0005501_abnormal_skin_physiology0.72550358
116MP0005023_abnormal_wound_healing0.70036045
117MP0000767_abnormal_smooth_muscle0.69762091
118MP0000537_abnormal_urethra_morphology0.69497909
119MP0000266_abnormal_heart_morphology0.69417334
120MP0005595_abnormal_vascular_smooth0.68021160
121MP0000534_abnormal_ureter_morphology0.67444723
122MP0009115_abnormal_fat_cell0.67027352
123MP0002078_abnormal_glucose_homeostasis0.66218899
124MP0003453_abnormal_keratinocyte_physiol0.65305608
125MP0008260_abnormal_autophagy0.63346795
126MP0002896_abnormal_bone_mineralization0.63052883
127MP0000462_abnormal_digestive_system0.62840185
128MP0001879_abnormal_lymphatic_vessel0.62401142
129MP0000230_abnormal_systemic_arterial0.61828315
130MP0009780_abnormal_chondrocyte_physiolo0.60665468

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.86936603
2Exercise-induced muscle cramps (HP:0003710)4.76632604
3Sudden death (HP:0001699)4.70910934
4Right ventricular cardiomyopathy (HP:0011663)4.69500986
5Hyporeflexia of lower limbs (HP:0002600)4.49153806
6Increased connective tissue (HP:0009025)4.44003284
7Muscle fiber splitting (HP:0003555)4.43638001
8Ventricular tachycardia (HP:0004756)4.24515386
9Myoglobinuria (HP:0002913)4.24163310
10Calf muscle hypertrophy (HP:0008981)3.98757382
11Muscle hypertrophy of the lower extremities (HP:0008968)3.83334005
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.80088819
13Type 1 muscle fiber predominance (HP:0003803)3.74561971
14Difficulty running (HP:0009046)3.68291757
15Abnormality of the calf musculature (HP:0001430)3.42035170
16Deep venous thrombosis (HP:0002625)3.31762339
17Rhabdomyolysis (HP:0003201)3.21619966
18Muscle fiber inclusion bodies (HP:0100299)3.19414524
19Asymmetric septal hypertrophy (HP:0001670)3.19235737
20Xanthomatosis (HP:0000991)3.18167885
21EMG: myopathic abnormalities (HP:0003458)3.17434539
22Lipoatrophy (HP:0100578)3.10045708
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.09985125
24Subaortic stenosis (HP:0001682)3.00620611
25Abnormality of the left ventricular outflow tract (HP:0011103)3.00620611
26Hypoglycemic coma (HP:0001325)2.93804389
27Difficulty climbing stairs (HP:0003551)2.90364084
28Ketosis (HP:0001946)2.90274641
29Ketoacidosis (HP:0001993)2.90176386
30Hypoalphalipoproteinemia (HP:0003233)2.88905769
31Atrial fibrillation (HP:0005110)2.85888962
32Increased variability in muscle fiber diameter (HP:0003557)2.80612724
33Bundle branch block (HP:0011710)2.76979172
34Lower limb amyotrophy (HP:0007210)2.71435765
35Hyperammonemia (HP:0001987)2.70285032
36Intrahepatic cholestasis (HP:0001406)2.70268506
37Hyperglycinuria (HP:0003108)2.70113120
38Abnormality of fatty-acid metabolism (HP:0004359)2.64278522
39Primary atrial arrhythmia (HP:0001692)2.63524915
40Dilated cardiomyopathy (HP:0001644)2.63365250
41Abnormality of skeletal muscle fiber size (HP:0012084)2.62977807
42Muscle stiffness (HP:0003552)2.58913449
43Round ear (HP:0100830)2.56453631
44Palpitations (HP:0001962)2.54692263
45Atrioventricular block (HP:0001678)2.53029983
46Myotonia (HP:0002486)2.51144796
47Supraventricular arrhythmia (HP:0005115)2.49274488
48Syncope (HP:0001279)2.48858534
49Ventricular arrhythmia (HP:0004308)2.47943484
50Supraventricular tachycardia (HP:0004755)2.47313098
51Nemaline bodies (HP:0003798)2.46424060
52Broad metatarsal (HP:0001783)2.45949212
53Abnormal atrioventricular conduction (HP:0005150)2.44559697
54Heart block (HP:0012722)2.42870141
55Abnormality of glycine metabolism (HP:0010895)2.42730208
56Abnormality of serine family amino acid metabolism (HP:0010894)2.42730208
57Hyperlipoproteinemia (HP:0010980)2.41275584
58Protrusio acetabuli (HP:0003179)2.37498740
59Distal lower limb muscle weakness (HP:0009053)2.36243325
60Mildly elevated creatine phosphokinase (HP:0008180)2.36054188
61Hypolipoproteinemia (HP:0010981)2.32517257
62Premature rupture of membranes (HP:0001788)2.30882147
63Complement deficiency (HP:0004431)2.29291812
64Conjunctival hamartoma (HP:0100780)2.24385204
65Abnormality of the Achilles tendon (HP:0005109)2.24328823
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.22888340
67Foot dorsiflexor weakness (HP:0009027)2.22122089
68Atrophic scars (HP:0001075)2.21274453
69Hyperacusis (HP:0010780)2.20554515
70Bulbar palsy (HP:0001283)2.17892261
71Skin nodule (HP:0200036)2.17079111
72Fragile skin (HP:0001030)2.16846174
73Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16769172
74Abnormality of the foot musculature (HP:0001436)2.15602250
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13306469
76Cholelithiasis (HP:0001081)2.12227512
77Epidermoid cyst (HP:0200040)2.12198044
78Aortic aneurysm (HP:0004942)2.10748700
79Distal arthrogryposis (HP:0005684)2.10106296
80Shallow orbits (HP:0000586)2.09980113
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09579963
82Gout (HP:0001997)2.09484517
83Cerebral aneurysm (HP:0004944)2.09045890
84Myopathic facies (HP:0002058)2.07982142
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07622711
86Dicarboxylic aciduria (HP:0003215)2.07622711
87Distal lower limb amyotrophy (HP:0008944)2.07313980
88Achilles tendon contracture (HP:0001771)2.07157617
89Lymphangioma (HP:0100764)2.06809337
90Rimmed vacuoles (HP:0003805)2.05849595
91Calcaneovalgus deformity (HP:0001848)2.05826754
92Myocardial infarction (HP:0001658)2.05615144
93Scapular winging (HP:0003691)2.04435986
94Slender build (HP:0001533)2.03821547
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00628690
96Spinal rigidity (HP:0003306)1.99857366
97Ventricular fibrillation (HP:0001663)1.98920935
98Prolonged QT interval (HP:0001657)1.98083838
99Vascular tortuosity (HP:0004948)1.97705248
100Limb-girdle muscle atrophy (HP:0003797)1.97574792
101Ulnar bowing (HP:0003031)1.96710236
102Hyperglycinemia (HP:0002154)1.93824456
103Arterial tortuosity (HP:0005116)1.93431718
104Abnormal gallbladder morphology (HP:0012437)1.92326932
105Facial diplegia (HP:0001349)1.91316237
106Neck muscle weakness (HP:0000467)1.89548975
107Back pain (HP:0003418)1.89129806
108Generalized muscle weakness (HP:0003324)1.88615969
109Hamartoma of the eye (HP:0010568)1.87298236
110Generalized amyotrophy (HP:0003700)1.86548038
111Vertebral compression fractures (HP:0002953)1.86383745
112Dysmetric saccades (HP:0000641)1.85800723
113Hypoplastic ischia (HP:0003175)1.84615322
114Abnormality of purine metabolism (HP:0004352)1.84031764
115Areflexia of lower limbs (HP:0002522)1.82695351
116Hypobetalipoproteinemia (HP:0003563)1.82091987
117Aneurysm (HP:0002617)1.80894986
118Distal upper limb amyotrophy (HP:0007149)1.80470513
119Upper limb amyotrophy (HP:0009129)1.80470513
120Ankle contracture (HP:0006466)1.79038605
121Advanced eruption of teeth (HP:0006288)1.78309949
122Deformed tarsal bones (HP:0008119)1.76456297
123Ulnar deviation of the wrist (HP:0003049)1.76192923
124Hydroxyprolinuria (HP:0003080)1.75418073
125Abnormality of proline metabolism (HP:0010907)1.75418073
126Stridor (HP:0010307)1.74649539
127Hyperglycemia (HP:0003074)1.74354005
128Bladder diverticulum (HP:0000015)1.74157601
129Wormian bones (HP:0002645)1.73976793
130EMG: neuropathic changes (HP:0003445)1.73938146
131Abnormality of the calcaneus (HP:0008364)1.73717720
132Obstructive sleep apnea (HP:0002870)1.69802675
133Aortic dissection (HP:0002647)1.68920364
134Gowers sign (HP:0003391)1.68366387
135Malignant hyperthermia (HP:0002047)1.68114951
136Flat acetabular roof (HP:0003180)1.67115280
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.65981582
138Osteolytic defects of the hand bones (HP:0009699)1.65981582
139Hip contracture (HP:0003273)1.65766575
140Muscular dystrophy (HP:0003560)1.64002044
141Broad face (HP:0000283)1.63419881
142Limb-girdle muscle weakness (HP:0003325)1.61259397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.12360143
2TRIB34.40212193
3PKN23.27268932
4OBSCN2.89732579
5BCKDK2.76158379
6PHKG12.58824121
7PHKG22.58824121
8SIK12.33057229
9LMTK22.27153531
10ERN12.24891363
11RIPK12.16064329
12PDK42.05621157
13PDK32.05621157
14DMPK2.02675189
15LATS11.83625508
16SMG11.79513396
17PRPF4B1.68786569
18PDGFRA1.67842513
19IRAK31.65338716
20PTK61.64019730
21MYLK1.60326116
22MAP3K71.48889674
23FGFR41.47074067
24PIK3CA1.43375890
25NEK11.38095069
26TIE11.35827700
27MST1R1.33095392
28TESK11.32759410
29MAP2K31.32632699
30PDK21.29409883
31EPHB11.28167649
32CDK121.19461076
33MAP3K31.19127088
34NTRK11.19126474
35PINK11.17552478
36PIK3CG1.16846457
37DDR21.16202639
38CAMK1D1.14300314
39FER1.13572723
40LIMK11.13057953
41PAK31.09894588
42TGFBR21.02903031
43EPHB21.01202365
44NEK91.00648930
45PRKD11.00244255
46PRKAA20.99870354
47BMX0.99629988
48ARAF0.99415782
49MUSK0.96522642
50MAPKAPK30.95250911
51LRRK20.94444766
52CAMK1G0.87643866
53LATS20.85611670
54TRPM70.85460289
55EEF2K0.85270436
56CAMK2G0.85024753
57RPS6KA20.84447333
58MAP3K100.82824006
59ICK0.81487851
60MAPK120.80387602
61MAP3K60.78870477
62MAP3K90.77725363
63MAP3K130.76708233
64PTK20.76655137
65STK380.76277428
66ROCK10.76227157
67MET0.76002203
68PRKAA10.74684413
69STK38L0.70516026
70MOS0.70010486
71INSRR0.69731526
72WNK40.69722277
73TAOK20.68747328
74ILK0.67353929
75MTOR0.66060749
76PRKD20.66040300
77MAP2K40.65896927
78JAK10.65589371
79FLT30.65385577
80CAMK2B0.62319162
81ROCK20.61751602
82MARK20.60746861
83EPHA20.60630674
84PAK20.60412448
85PDPK10.60295771
86MAPK110.60266480
87TAOK10.59588303
88RET0.59567472
89PAK60.58955018
90MAP2K10.58106711
91FRK0.56365013
92RPS6KB20.55338414
93FGFR20.55217264
94PDGFRB0.54628093
95FGFR30.53870973
96PTK2B0.52653892
97STK240.52638749
98PRKCH0.52465840
99RPS6KL10.51234901
100RPS6KC10.51234901
101KDR0.48336069
102DYRK1B0.48025722
103CAMK2D0.47534676
104KSR20.46930960
105DAPK30.46890016
106JAK20.45586899
107FGFR10.45434415
108SCYL20.44968840
109MAP3K50.43868786
110PAK40.43618543
111CDC42BPA0.43202758
112PRKG20.43045065
113WNK10.42957708
114MAP3K10.42545156
115PRKD30.42346713
116SGK30.42208356
117CDK60.41907705
118MAPK40.41782138
119ERBB40.41369630
120TBK10.41105407
121ABL20.40057047
122BRAF0.37799941
123MAP3K20.37539277
124EPHA30.37209504
125GSK3A0.37193036
126MAPK70.37030937
127AKT20.36902543
128PRKACG0.36355770
129CAMK40.35959598
130TYK20.35956838
131PDK10.34385772
132TYRO30.34360255
133RPS6KA60.33622860
134MAPK100.33601280

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45500640
2Fatty acid degradation_Homo sapiens_hsa000713.09384672
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.08254396
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.01385196
5Nitrogen metabolism_Homo sapiens_hsa009102.85197712
6Propanoate metabolism_Homo sapiens_hsa006402.75875916
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59123355
8Arginine biosynthesis_Homo sapiens_hsa002202.44137313
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.38686000
10Fatty acid metabolism_Homo sapiens_hsa012122.38635831
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24601091
12PPAR signaling pathway_Homo sapiens_hsa033202.21638091
13Tryptophan metabolism_Homo sapiens_hsa003802.04183069
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95711555
15Butanoate metabolism_Homo sapiens_hsa006501.89165125
16Carbon metabolism_Homo sapiens_hsa012001.85523420
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70476622
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.65734825
19Dilated cardiomyopathy_Homo sapiens_hsa054141.65443549
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63358139
21Pyruvate metabolism_Homo sapiens_hsa006201.62761225
22Starch and sucrose metabolism_Homo sapiens_hsa005001.52776222
23Complement and coagulation cascades_Homo sapiens_hsa046101.50170456
24beta-Alanine metabolism_Homo sapiens_hsa004101.47453796
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.41043432
26Peroxisome_Homo sapiens_hsa041461.38106173
27Bile secretion_Homo sapiens_hsa049761.36221505
28Caffeine metabolism_Homo sapiens_hsa002321.33088378
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25173901
30Fatty acid biosynthesis_Homo sapiens_hsa000611.23991914
31Fat digestion and absorption_Homo sapiens_hsa049751.21318657
32Phenylalanine metabolism_Homo sapiens_hsa003601.19687860
33Biosynthesis of amino acids_Homo sapiens_hsa012301.18536380
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14210246
35Prion diseases_Homo sapiens_hsa050201.14058848
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13981622
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13796888
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13290767
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13055977
40Insulin resistance_Homo sapiens_hsa049311.11232381
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.10904257
42GnRH signaling pathway_Homo sapiens_hsa049121.09944303
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08930104
44Cardiac muscle contraction_Homo sapiens_hsa042601.08566917
45Fatty acid elongation_Homo sapiens_hsa000621.07504245
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06028858
47Lysine degradation_Homo sapiens_hsa003101.04714756
48Chemical carcinogenesis_Homo sapiens_hsa052040.96635008
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94295114
50Staphylococcus aureus infection_Homo sapiens_hsa051500.93007515
51Glioma_Homo sapiens_hsa052140.92144744
52Long-term potentiation_Homo sapiens_hsa047200.91584075
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89566127
54Oxytocin signaling pathway_Homo sapiens_hsa049210.88560911
55Circadian rhythm_Homo sapiens_hsa047100.88282380
56Histidine metabolism_Homo sapiens_hsa003400.87600470
57ECM-receptor interaction_Homo sapiens_hsa045120.86717155
58Arginine and proline metabolism_Homo sapiens_hsa003300.85603421
59Tyrosine metabolism_Homo sapiens_hsa003500.83853487
60Chronic myeloid leukemia_Homo sapiens_hsa052200.83040665
61Renin secretion_Homo sapiens_hsa049240.81925226
62Sulfur metabolism_Homo sapiens_hsa009200.81901262
63Focal adhesion_Homo sapiens_hsa045100.80151184
64Endometrial cancer_Homo sapiens_hsa052130.79395466
65Other glycan degradation_Homo sapiens_hsa005110.79030808
66Estrogen signaling pathway_Homo sapiens_hsa049150.78740140
67Thyroid cancer_Homo sapiens_hsa052160.77675529
68ABC transporters_Homo sapiens_hsa020100.77222753
69AMPK signaling pathway_Homo sapiens_hsa041520.76335952
70Glycerolipid metabolism_Homo sapiens_hsa005610.75912280
71Glucagon signaling pathway_Homo sapiens_hsa049220.74952881
72Insulin signaling pathway_Homo sapiens_hsa049100.73135703
73Vitamin B6 metabolism_Homo sapiens_hsa007500.72344397
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71573474
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71234678
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70925881
77Retinol metabolism_Homo sapiens_hsa008300.70575356
78Melanogenesis_Homo sapiens_hsa049160.70005829
79Calcium signaling pathway_Homo sapiens_hsa040200.69620885
80Renal cell carcinoma_Homo sapiens_hsa052110.68446419
81Amoebiasis_Homo sapiens_hsa051460.67069151
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.66429709
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.66221134
84ErbB signaling pathway_Homo sapiens_hsa040120.65972880
85Selenocompound metabolism_Homo sapiens_hsa004500.63617725
86Viral myocarditis_Homo sapiens_hsa054160.60712279
87Gap junction_Homo sapiens_hsa045400.60173092
88Thyroid hormone synthesis_Homo sapiens_hsa049180.57134667
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.57110319
90Hippo signaling pathway_Homo sapiens_hsa043900.57005941
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56948536
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55496477
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55467384
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55141730
95Non-small cell lung cancer_Homo sapiens_hsa052230.54668506
96Galactose metabolism_Homo sapiens_hsa000520.53391464
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53167605
98Notch signaling pathway_Homo sapiens_hsa043300.53162961
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.52793113
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52779712
101Adherens junction_Homo sapiens_hsa045200.52310595
102Inositol phosphate metabolism_Homo sapiens_hsa005620.51408871
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.49959283
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.49220649
105Pancreatic cancer_Homo sapiens_hsa052120.47756638
106Proteoglycans in cancer_Homo sapiens_hsa052050.47571790
107Tight junction_Homo sapiens_hsa045300.47540423
108Fructose and mannose metabolism_Homo sapiens_hsa000510.46901470
109Insulin secretion_Homo sapiens_hsa049110.45130112
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44720544
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44554113
112Protein digestion and absorption_Homo sapiens_hsa049740.44304994
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43142504
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42698558
115Endocytosis_Homo sapiens_hsa041440.41722706
116Choline metabolism in cancer_Homo sapiens_hsa052310.41219751
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40739520
118Pentose phosphate pathway_Homo sapiens_hsa000300.37343687
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.35181521
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34509738
121Sulfur relay system_Homo sapiens_hsa041220.34160401
122Bladder cancer_Homo sapiens_hsa052190.33835809
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33131918
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.32437925
125Type II diabetes mellitus_Homo sapiens_hsa049300.31010797
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29256758
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.27977766
128HIF-1 signaling pathway_Homo sapiens_hsa040660.27339525
129Small cell lung cancer_Homo sapiens_hsa052220.25826104
130Vitamin digestion and absorption_Homo sapiens_hsa049770.25496208
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21610649
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.20946115
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20462566
134mTOR signaling pathway_Homo sapiens_hsa041500.19569260
135Glutathione metabolism_Homo sapiens_hsa004800.19407689
136Gastric acid secretion_Homo sapiens_hsa049710.17517538
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15507651
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15200349
139VEGF signaling pathway_Homo sapiens_hsa043700.14575310
140Dorso-ventral axis formation_Homo sapiens_hsa043200.13819757

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