KIF20A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.55775467
2mitotic metaphase plate congression (GO:0007080)5.36138370
3mitotic sister chromatid segregation (GO:0000070)4.94915761
4regulation of spindle organization (GO:0090224)4.87511388
5regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.86916071
6protein localization to chromosome, centromeric region (GO:0071459)4.85947670
7metaphase plate congression (GO:0051310)4.71914042
8nuclear pore organization (GO:0006999)4.67079693
9DNA unwinding involved in DNA replication (GO:0006268)4.66834635
10sister chromatid segregation (GO:0000819)4.64775494
11mitotic nuclear envelope disassembly (GO:0007077)4.62763291
12kinetochore organization (GO:0051383)4.56526676
13establishment of integrated proviral latency (GO:0075713)4.54389833
14mitotic chromosome condensation (GO:0007076)4.48440070
15nuclear pore complex assembly (GO:0051292)4.47825809
16DNA ligation (GO:0006266)4.39959846
17regulation of mitotic spindle organization (GO:0060236)4.39519781
18nuclear envelope disassembly (GO:0051081)4.31102784
19membrane disassembly (GO:0030397)4.31102784
20establishment of chromosome localization (GO:0051303)4.28963033
21positive regulation of chromosome segregation (GO:0051984)4.28690105
22attachment of spindle microtubules to kinetochore (GO:0008608)4.25392945
23DNA replication initiation (GO:0006270)4.24270341
24DNA strand elongation involved in DNA replication (GO:0006271)4.21723253
25DNA replication-dependent nucleosome assembly (GO:0006335)4.20597627
26DNA replication-dependent nucleosome organization (GO:0034723)4.20597627
27CENP-A containing nucleosome assembly (GO:0034080)4.11989848
28chromatin remodeling at centromere (GO:0031055)4.09540329
29kinetochore assembly (GO:0051382)4.07505214
30DNA strand elongation (GO:0022616)4.00004576
31DNA replication checkpoint (GO:0000076)3.98898334
32regulation of chromosome segregation (GO:0051983)3.97602355
33spindle checkpoint (GO:0031577)3.97224551
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88653899
35negative regulation of chromosome segregation (GO:0051985)3.87999156
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.86336804
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.86336804
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.86336804
39nucleobase biosynthetic process (GO:0046112)3.84998334
40spindle assembly checkpoint (GO:0071173)3.82207108
41DNA replication-independent nucleosome assembly (GO:0006336)3.82187861
42DNA replication-independent nucleosome organization (GO:0034724)3.82187861
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.82061591
44negative regulation of sister chromatid segregation (GO:0033046)3.82061591
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.82061591
46negative regulation of mitotic sister chromatid segregation (GO:0033048)3.82061591
47regulation of mitotic metaphase/anaphase transition (GO:0030071)3.78886627
48mitotic spindle checkpoint (GO:0071174)3.78079159
49mitotic spindle assembly checkpoint (GO:0007094)3.76726426
50telomere maintenance via semi-conservative replication (GO:0032201)3.73281280
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.72917550
52regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.71892935
53protein localization to chromosome (GO:0034502)3.70039501
54formation of translation preinitiation complex (GO:0001731)3.67187375
55histone exchange (GO:0043486)3.64353786
56mitotic cytokinesis (GO:0000281)3.63545360
57purine nucleobase biosynthetic process (GO:0009113)3.59082914
58regulation of mitotic sister chromatid separation (GO:0010965)3.58408231
59regulation of mitotic sister chromatid segregation (GO:0033047)3.58408231
60regulation of sister chromatid segregation (GO:0033045)3.58408231
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57315321
62ventricular cardiac muscle cell development (GO:0055015)3.55806072
63mitotic recombination (GO:0006312)3.55475173
64protein complex localization (GO:0031503)3.55031910
65regulation of centrosome cycle (GO:0046605)3.53847704
66folic acid-containing compound biosynthetic process (GO:0009396)3.50599716
67meiotic chromosome segregation (GO:0045132)3.50413505
68chromosome segregation (GO:0007059)3.49000344
69telomere maintenance via recombination (GO:0000722)3.48455687
70IMP biosynthetic process (GO:0006188)3.48404342
71pore complex assembly (GO:0046931)3.45731065
72establishment of viral latency (GO:0019043)3.41658738
73spindle assembly involved in mitosis (GO:0090307)3.41594113
74ribosome assembly (GO:0042255)3.40598172
75nuclear envelope organization (GO:0006998)3.39634272
76regulation of sister chromatid cohesion (GO:0007063)3.33081633
77DNA duplex unwinding (GO:0032508)3.30664736
78DNA geometric change (GO:0032392)3.30210366
79maturation of SSU-rRNA (GO:0030490)3.28722020
80chromosome condensation (GO:0030261)3.28593908
81chromatin assembly or disassembly (GO:0006333)3.28439885
82mitotic sister chromatid cohesion (GO:0007064)3.24421705
83microtubule depolymerization (GO:0007019)3.24106136
84telomere maintenance via telomere lengthening (GO:0010833)3.24072360
85mitotic spindle organization (GO:0007052)3.21508214
86protein K6-linked ubiquitination (GO:0085020)3.19771096
87double-strand break repair via nonhomologous end joining (GO:0006303)3.19553179
88non-recombinational repair (GO:0000726)3.19553179
89histone-serine phosphorylation (GO:0035404)3.14811840
90regulation of translational fidelity (GO:0006450)3.13342532
91ribosome biogenesis (GO:0042254)3.12028626
92ATP-dependent chromatin remodeling (GO:0043044)3.09082545
93regulation of telomere maintenance via telomerase (GO:0032210)3.05730638
94regulation of centriole replication (GO:0046599)3.05505969
95heterochromatin organization (GO:0070828)3.05306322
96cellular protein complex localization (GO:0034629)3.05105594
97nucleotide-excision repair, DNA gap filling (GO:0006297)3.04662365
98spindle organization (GO:0007051)3.04556395
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04008009
100somatic hypermutation of immunoglobulin genes (GO:0016446)3.04008009
101IMP metabolic process (GO:0046040)3.02254864
102negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.01976220
103DNA conformation change (GO:0071103)3.00348869
104spliceosomal snRNP assembly (GO:0000387)2.97190009
105* mitotic cell cycle (GO:0000278)2.96944851
106DNA topological change (GO:0006265)2.96283902
107establishment of mitotic spindle localization (GO:0040001)2.95958726
108negative regulation of mitosis (GO:0045839)2.95911361
109anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93980315
110regulation of histone H3-K9 methylation (GO:0051570)2.93509117
111microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.93129648
112DNA packaging (GO:0006323)2.92899754
113regulation of double-strand break repair via homologous recombination (GO:0010569)2.92331125
114regulation of gene silencing by RNA (GO:0060966)2.91381668
115regulation of posttranscriptional gene silencing (GO:0060147)2.91381668
116regulation of gene silencing by miRNA (GO:0060964)2.91381668
117cytoskeleton-dependent cytokinesis (GO:0061640)2.91023005
118regulation of centrosome duplication (GO:0010824)2.89747801
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87534883
120mitotic nuclear division (GO:0007067)2.87318262
121regulation of exit from mitosis (GO:0007096)2.86936927
122negative regulation of nuclear division (GO:0051784)2.85327245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.05244065
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.37855123
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32540332
4* MYC_18555785_ChIP-Seq_MESCs_Mouse4.06579771
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.97851592
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23718710
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99286415
8* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.90123299
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76055491
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75091648
11* AR_21909140_ChIP-Seq_LNCAP_Human2.60986849
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57872296
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55293480
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45728086
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43263570
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.38198663
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.28418259
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27977926
19* XRN2_22483619_ChIP-Seq_HELA_Human2.24552086
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.22384527
21* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20986532
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20922086
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.17146049
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15536566
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09850526
26* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92876155
27VDR_23849224_ChIP-Seq_CD4+_Human1.88294947
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88254400
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83314012
30DCP1A_22483619_ChIP-Seq_HELA_Human1.79043978
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75525738
32FOXP3_21729870_ChIP-Seq_TREG_Human1.73694574
33TTF2_22483619_ChIP-Seq_HELA_Human1.72928056
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65287523
35GABP_19822575_ChIP-Seq_HepG2_Human1.63725860
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63511328
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59640997
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58841110
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58702864
40* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55580648
41CIITA_25753668_ChIP-Seq_RAJI_Human1.53071711
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52110090
43ELK1_19687146_ChIP-ChIP_HELA_Human1.50270487
44KDM5A_27292631_Chip-Seq_BREAST_Human1.48919555
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48785125
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47752372
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47346942
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46383707
49MYC_22102868_ChIP-Seq_BL_Human1.44335699
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40118161
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38808901
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.35110515
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35096771
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.33854073
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33417949
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32145872
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32137583
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31322290
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28300272
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24042037
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.23248407
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22876698
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22576082
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20763128
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19830114
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19767531
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17665121
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17644384
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16728552
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.16262642
71ZNF263_19887448_ChIP-Seq_K562_Human1.14728956
72* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11060971
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10603810
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10475164
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10158794
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10158794
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10158794
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09592343
79TFEB_21752829_ChIP-Seq_HELA_Human1.08034963
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07558142
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07487367
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07263354
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.07237173
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05745297
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99994141
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97358328
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97039806
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.96561133
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95282245
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94790192
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94276023
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93128974
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93055738
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92228893
95CHD1_26751641_Chip-Seq_LNCaP_Human0.90175694
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89997120
97NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89440738
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89252296
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.87856985
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87522590
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85236372
102MYC_18940864_ChIP-ChIP_HL60_Human0.84569446
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83321167
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82995284
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82455418
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81781787
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81105022
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.80043932
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79581921
110* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79277845
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78925571
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78060339
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77421006
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73854638
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72908450
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69770448
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69509791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.26760356
2MP0003111_abnormal_nucleus_morphology4.90109571
3MP0010094_abnormal_chromosome_stability4.71775176
4MP0004957_abnormal_blastocyst_morpholog4.31600843
5MP0003077_abnormal_cell_cycle4.16788996
6MP0008057_abnormal_DNA_replication3.75546618
7MP0008058_abnormal_DNA_repair2.97221347
8MP0008007_abnormal_cellular_replicative2.87252918
9MP0008932_abnormal_embryonic_tissue2.78507962
10MP0003123_paternal_imprinting2.74885422
11MP0001730_embryonic_growth_arrest2.60478486
12MP0000350_abnormal_cell_proliferation2.37652138
13MP0010352_gastrointestinal_tract_polyps2.24473403
14MP0008877_abnormal_DNA_methylation2.18706028
15MP0010307_abnormal_tumor_latency2.16850984
16MP0010030_abnormal_orbit_morphology2.15535704
17MP0002877_abnormal_melanocyte_morpholog2.15276020
18MP0005380_embryogenesis_phenotype1.99879686
19MP0001672_abnormal_embryogenesis/_devel1.99879686
20MP0001697_abnormal_embryo_size1.93963552
21MP0003786_premature_aging1.88363516
22MP0002085_abnormal_embryonic_tissue1.82113616
23MP0009697_abnormal_copulation1.81832151
24MP0003984_embryonic_growth_retardation1.75837236
25MP0002084_abnormal_developmental_patter1.73411199
26MP0002088_abnormal_embryonic_growth/wei1.72887729
27MP0002080_prenatal_lethality1.70725311
28MP0003718_maternal_effect1.67688319
29MP0005076_abnormal_cell_differentiation1.65745455
30MP0004197_abnormal_fetal_growth/weight/1.60014473
31MP0002086_abnormal_extraembryonic_tissu1.57586330
32MP0002396_abnormal_hematopoietic_system1.56470497
33MP0003121_genomic_imprinting1.53289315
34MP0003705_abnormal_hypodermis_morpholog1.50243442
35MP0003567_abnormal_fetal_cardiomyocyte1.45898948
36MP0009053_abnormal_anal_canal1.45277655
37MP0000537_abnormal_urethra_morphology1.39758300
38MP0003950_abnormal_plasma_membrane1.36255343
39MP0002210_abnormal_sex_determination1.34573140
40MP0003941_abnormal_skin_development1.34475912
41MP0003890_abnormal_embryonic-extraembry1.34273128
42MP0001293_anophthalmia1.33301930
43MP0000313_abnormal_cell_death1.32323742
44MP0000490_abnormal_crypts_of1.26369315
45MP0003937_abnormal_limbs/digits/tail_de1.25752104
46MP0004808_abnormal_hematopoietic_stem1.23193268
47MP0002019_abnormal_tumor_incidence1.22925776
48MP0004272_abnormal_basement_membrane1.20611415
49MP0001145_abnormal_male_reproductive1.18919713
50MP0003119_abnormal_digestive_system1.16297553
51MP0003315_abnormal_perineum_morphology1.15648036
52MP0001346_abnormal_lacrimal_gland1.12355654
53MP0001929_abnormal_gametogenesis1.10432544
54MP0009672_abnormal_birth_weight1.05220048
55MP0002111_abnormal_tail_morphology1.05182123
56MP0000653_abnormal_sex_gland1.01220731
57MP0004185_abnormal_adipocyte_glucose0.98740837
58MP0000428_abnormal_craniofacial_morphol0.96094505
59MP0010234_abnormal_vibrissa_follicle0.95523053
60MP0002653_abnormal_ependyma_morphology0.94520215
61MP0005257_abnormal_intraocular_pressure0.93936202
62MP0004133_heterotaxia0.92318497
63MP0003566_abnormal_cell_adhesion0.92122108
64MP0005501_abnormal_skin_physiology0.92095143
65MP0005023_abnormal_wound_healing0.91787957
66MP0002233_abnormal_nose_morphology0.89237753
67MP0009703_decreased_birth_body0.88210417
68MP0005171_absent_coat_pigmentation0.87800136
69MP0000762_abnormal_tongue_morphology0.86418272
70MP0000566_synostosis0.85273707
71MP0006054_spinal_hemorrhage0.83014177
72MP0000733_abnormal_muscle_development0.82858413
73MP0002160_abnormal_reproductive_system0.82824439
74MP0008438_abnormal_cutaneous_collagen0.81943942
75MP0001299_abnormal_eye_distance/0.81465755
76MP0002092_abnormal_eye_morphology0.81260023
77MP0003806_abnormal_nucleotide_metabolis0.81142326
78MP0000432_abnormal_head_morphology0.79475659
79MP0001915_intracranial_hemorrhage0.79449665
80MP0003115_abnormal_respiratory_system0.78907726
81MP0001849_ear_inflammation0.78748004
82MP0005384_cellular_phenotype0.78508922
83MP0005621_abnormal_cell_physiology0.78251762
84MP0000579_abnormal_nail_morphology0.78132190
85MP0001119_abnormal_female_reproductive0.75868042
86MP0001661_extended_life_span0.75747027
87MP0009333_abnormal_splenocyte_physiolog0.75318840
88MP0000703_abnormal_thymus_morphology0.74096740
89MP0003935_abnormal_craniofacial_develop0.73818665
90MP0001545_abnormal_hematopoietic_system0.72998975
91MP0005397_hematopoietic_system_phenotyp0.72998975
92MP0002009_preneoplasia0.72439535
93MP0001286_abnormal_eye_development0.72431424
94MP0003221_abnormal_cardiomyocyte_apopto0.71582495
95MP0006035_abnormal_mitochondrial_morpho0.71330018
96MP0000358_abnormal_cell_content/0.71303174
97MP0005389_reproductive_system_phenotype0.71185675
98MP0003755_abnormal_palate_morphology0.70652500
99MP0009278_abnormal_bone_marrow0.70518588
100MP0006292_abnormal_olfactory_placode0.69304588
101MP0005197_abnormal_uvea_morphology0.67262270
102MP0005623_abnormal_meninges_morphology0.66908076
103MP0002938_white_spotting0.66808629
104MP0002060_abnormal_skin_morphology0.66394883
105MP0004233_abnormal_muscle_weight0.66193338
106MP0002697_abnormal_eye_size0.65933184
107MP0005408_hypopigmentation0.65911222
108MP0003861_abnormal_nervous_system0.65611116
109MP0002796_impaired_skin_barrier0.65434542
110MP0002932_abnormal_joint_morphology0.64394642
111MP0002234_abnormal_pharynx_morphology0.63993508
112MP0009250_abnormal_appendicular_skeleto0.63402531
113MP0002925_abnormal_cardiovascular_devel0.63281291
114MP0004264_abnormal_extraembryonic_tissu0.62410941
115MP0000858_altered_metastatic_potential0.62336636
116MP0002114_abnormal_axial_skeleton0.62282820
117MP0003943_abnormal_hepatobiliary_system0.61532965
118MP0001727_abnormal_embryo_implantation0.61439467
119MP0003698_abnormal_male_reproductive0.59211147
120MP0003385_abnormal_body_wall0.58145792
121MP0002282_abnormal_trachea_morphology0.57205355
122MP0002161_abnormal_fertility/fecundity0.56741659
123MP0000049_abnormal_middle_ear0.56713204
124MP0000516_abnormal_urinary_system0.56378561
125MP0005367_renal/urinary_system_phenotyp0.56378561
126MP0003942_abnormal_urinary_system0.55788713
127MP0002722_abnormal_immune_system0.54175423

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.20080765
2Chromsome breakage (HP:0040012)3.91591941
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78365706
4Breast hypoplasia (HP:0003187)3.74299130
5Cortical dysplasia (HP:0002539)3.69416721
6Selective tooth agenesis (HP:0001592)3.52504956
7Patellar aplasia (HP:0006443)3.45207155
8Impulsivity (HP:0100710)3.28863170
9Ependymoma (HP:0002888)3.28200018
10Aplasia/Hypoplasia of the patella (HP:0006498)3.26144397
11Meckel diverticulum (HP:0002245)3.25090985
12Abnormality of the labia minora (HP:0012880)3.21697216
13Medulloblastoma (HP:0002885)3.20334418
14Colon cancer (HP:0003003)3.19904442
15Abnormality of chromosome stability (HP:0003220)3.11634874
16Abnormality of the ileum (HP:0001549)3.06653387
17Carpal bone hypoplasia (HP:0001498)3.03709940
18Reticulocytopenia (HP:0001896)3.03491598
19Absent radius (HP:0003974)3.03205148
20Abnormality of the anterior horn cell (HP:0006802)2.93666106
21Degeneration of anterior horn cells (HP:0002398)2.93666106
22Duodenal stenosis (HP:0100867)2.93428976
23Small intestinal stenosis (HP:0012848)2.93428976
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.91901731
25Abnormality of the preputium (HP:0100587)2.91627440
26Abnormal lung lobation (HP:0002101)2.91160973
27Increased nuchal translucency (HP:0010880)2.82292108
28Absent forearm bone (HP:0003953)2.82011271
29Aplasia involving forearm bones (HP:0009822)2.82011271
30Supernumerary spleens (HP:0009799)2.68882045
31Oral leukoplakia (HP:0002745)2.67211201
32Rhabdomyosarcoma (HP:0002859)2.64364759
33Proximal placement of thumb (HP:0009623)2.61048416
34Deviation of the thumb (HP:0009603)2.59636918
35Ectopic kidney (HP:0000086)2.56822269
36Rough bone trabeculation (HP:0100670)2.56752338
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56566261
38Absent thumb (HP:0009777)2.50352885
39Sloping forehead (HP:0000340)2.49545856
40Myelodysplasia (HP:0002863)2.47710368
41Abnormality of the duodenum (HP:0002246)2.43927379
42Neoplasm of the pancreas (HP:0002894)2.42566245
43Atresia of the external auditory canal (HP:0000413)2.40737495
44Agnosia (HP:0010524)2.39179856
45Short 4th metacarpal (HP:0010044)2.39029134
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39029134
47Facial hemangioma (HP:0000329)2.33873888
48Astrocytoma (HP:0009592)2.28956563
49Abnormality of the astrocytes (HP:0100707)2.28956563
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.28941908
51Nephroblastoma (Wilms tumor) (HP:0002667)2.27957679
52Deep philtrum (HP:0002002)2.25506310
53Volvulus (HP:0002580)2.24207444
5411 pairs of ribs (HP:0000878)2.22931949
55Cerebral hypomyelination (HP:0006808)2.22568707
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.20891964
57Trismus (HP:0000211)2.20671441
58Glioma (HP:0009733)2.16845056
59Cafe-au-lait spot (HP:0000957)2.16576413
60Missing ribs (HP:0000921)2.15594636
61Broad distal phalanx of finger (HP:0009836)2.15150057
62Embryonal renal neoplasm (HP:0011794)2.15089163
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14256701
64Tracheoesophageal fistula (HP:0002575)2.13268219
65Aplasia/hypoplasia of the humerus (HP:0006507)2.13132917
66Abnormal umbilical cord blood vessels (HP:0011403)2.12952597
67Single umbilical artery (HP:0001195)2.12952597
68Abnormality of the fetal cardiovascular system (HP:0010948)2.12952597
69Basal cell carcinoma (HP:0002671)2.11736080
70Bone marrow hypocellularity (HP:0005528)2.10401943
71Premature rupture of membranes (HP:0001788)2.09644144
72Horseshoe kidney (HP:0000085)2.09491700
73Abnormal number of incisors (HP:0011064)2.08867351
74Abnormality of the carotid arteries (HP:0005344)2.05994326
75Short thumb (HP:0009778)2.05651531
76High anterior hairline (HP:0009890)2.03742196
77Abnormality of glycolysis (HP:0004366)2.02970070
78Premature graying of hair (HP:0002216)2.02704325
79Neoplasm of striated muscle (HP:0009728)2.02656951
80Triphalangeal thumb (HP:0001199)2.02562821
81Duplication of thumb phalanx (HP:0009942)2.02168354
82Abnormality of the calcaneus (HP:0008364)2.02108200
83Squamous cell carcinoma (HP:0002860)2.01028571
84Neoplasm of the colon (HP:0100273)1.98584173
85High pitched voice (HP:0001620)1.97894939
86Embryonal neoplasm (HP:0002898)1.95706110
87Abnormality of abdominal situs (HP:0011620)1.95005585
88Abdominal situs inversus (HP:0003363)1.95005585
89Ankle contracture (HP:0006466)1.94824827
90Neoplasm of the oral cavity (HP:0100649)1.92990945
91Microvesicular hepatic steatosis (HP:0001414)1.92540363
92Hypoplastic pelvis (HP:0008839)1.90551949
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90376093
94Absent epiphyses (HP:0010577)1.90376093
95Abnormality of cells of the erythroid lineage (HP:0012130)1.89888824
96Ureteral duplication (HP:0000073)1.88844111
97Abnormality of chromosome segregation (HP:0002916)1.87025604
98Spastic diplegia (HP:0001264)1.86208968
99Biliary tract neoplasm (HP:0100574)1.86100714
100Facial cleft (HP:0002006)1.85739350
101Duplicated collecting system (HP:0000081)1.85434117
102Short humerus (HP:0005792)1.84922251
103Oligodactyly (HP:0012165)1.84877019
104Overlapping toe (HP:0001845)1.84728483
105Premature ovarian failure (HP:0008209)1.84517073
106Abnormal trabecular bone morphology (HP:0100671)1.84225266
107Ovarian neoplasm (HP:0100615)1.82306182
108Hyperacusis (HP:0010780)1.81527111
109Slender long bone (HP:0003100)1.80664568
110Increased serum pyruvate (HP:0003542)1.80582712
111Multiple enchondromatosis (HP:0005701)1.79599392
112Small epiphyses (HP:0010585)1.79391982
113Secondary amenorrhea (HP:0000869)1.77632083
114Atrophy/Degeneration involving motor neurons (HP:0007373)1.77412795
115Shoulder girdle muscle weakness (HP:0003547)1.77126196
116Arteriovenous malformation (HP:0100026)1.76658157
117Orthostatic hypotension (HP:0001278)1.76254220
118Leiomyosarcoma (HP:0100243)1.76193058
119Uterine leiomyosarcoma (HP:0002891)1.76193058
120Progressive muscle weakness (HP:0003323)1.76118393
121Prominent nose (HP:0000448)1.76028171
122Cleft eyelid (HP:0000625)1.75766183
123Choanal atresia (HP:0000453)1.74516374
124Abnormality of the umbilical cord (HP:0010881)1.74400047
125Aplastic anemia (HP:0001915)1.73827911
126Pelvic girdle muscle weakness (HP:0003749)1.73340201
127Abnormality of the proximal phalanges of the hand (HP:0009834)1.72723242
128Abnormal number of erythroid precursors (HP:0012131)1.72592655
129Progressive external ophthalmoplegia (HP:0000590)1.68592256
130Ulnar bowing (HP:0003031)1.67407852
131Entropion (HP:0000621)1.66082744
132Insomnia (HP:0100785)1.64737777
133Microglossia (HP:0000171)1.64578669
134Overriding aorta (HP:0002623)1.62796743
135Abnormalities of placenta or umbilical cord (HP:0001194)1.62221124
136Abnormality of the phalanges of the hallux (HP:0010057)1.60733341
137Abnormal foot bone ossification (HP:0010675)1.59288867
138Malignant gastrointestinal tract tumors (HP:0006749)1.57133472
139Gastrointestinal carcinoma (HP:0002672)1.57133472
140Poikiloderma (HP:0001029)1.57103795
141Renal duplication (HP:0000075)1.57060141
142Glossoptosis (HP:0000162)1.56725385
143Ankyloglossia (HP:0010296)1.56635171
144Flared metaphyses (HP:0003015)1.52735159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.53421775
2WEE14.39761985
3CDC74.12265889
4NEK23.34442611
5TTK3.09950159
6EIF2AK12.64527905
7BRSK22.59908391
8NEK12.48135595
9PLK12.36995555
10SRPK12.21509550
11PLK42.12837298
12TSSK62.07052026
13CDK122.06297776
14PLK31.97713389
15BRSK11.96294714
16AURKB1.88911255
17TESK21.87082035
18VRK21.86779187
19MKNK11.84983025
20STK101.80682736
21MAP3K81.62746977
22CDK71.61017663
23CHEK21.60524611
24ATR1.58131511
25SMG11.57225156
26PASK1.56855719
27TLK11.55527705
28ACVR1B1.54862356
29AURKA1.49951759
30EPHA21.45432953
31RPS6KB21.43408528
32EEF2K1.41318771
33MKNK21.41019857
34CHEK11.34374959
35CDK41.33972781
36RPS6KA41.28186284
37DYRK31.27165906
38STK41.24644024
39TAF11.23238783
40MST1R1.22710031
41VRK11.21528274
42MELK1.20163694
43CCNB11.17246575
44PAK41.15589409
45MAP3K101.09937553
46EIF2AK31.04846555
47ZAK1.03516886
48STK31.03027254
49NME21.00041694
50ATM0.94730797
51TGFBR10.94693109
52TESK10.93463696
53ERBB40.93010156
54MET0.90778976
55CDK20.90265749
56LATS20.88163208
57PKN20.88000951
58CDK60.85579743
59STK160.84982627
60ALK0.84924350
61ICK0.84656927
62BRD40.84355497
63PAK10.82992743
64PBK0.82702239
65LATS10.79016596
66PDK30.78833109
67PDK40.78833109
68SCYL20.78786280
69CDK10.76176152
70PNCK0.73852372
71STK38L0.73407943
72BRAF0.65883051
73TRIM280.63920346
74PRKCI0.59932490
75MST40.59637580
76PDGFRA0.59116228
77PIM10.57124224
78EIF2AK20.55007146
79CSNK2A20.54135850
80MTOR0.53907662
81CSNK2A10.52996678
82FLT30.52963177
83LRRK20.51198866
84PTK20.49299256
85CLK10.48874453
86TTN0.46401778
87IRAK30.46219751
88TRIB30.40547119
89MARK30.40545633
90CDK80.39646097
91PAK20.39474157
92PDK20.38934859
93RPS6KA50.38381327
94CSNK1E0.38091076
95NME10.37383362
96AKT20.37166029
97PRKDC0.36579726
98FGFR10.35884767
99LIMK10.35231758
100BMX0.30369089
101NEK90.26149423
102MAPK140.25472028
103RAF10.25327215
104CSNK1D0.24329682
105PLK20.23749621
106ILK0.21964958
107KSR10.20727814
108CDK150.20718568
109CDK11A0.20493094
110CAMK1G0.20263946
111MAPK10.19647483
112MAPKAPK30.19634854
113MAPKAPK20.19455615
114CDK140.18515544
115AKT30.18173589
116CDK90.17890475
117CDK180.17747795
118GSK3B0.17690557
119AKT10.17199691

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.68314170
2Mismatch repair_Homo sapiens_hsa034304.16615022
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.73581013
4RNA transport_Homo sapiens_hsa030133.50512588
5Cell cycle_Homo sapiens_hsa041103.42245715
6Spliceosome_Homo sapiens_hsa030403.38322043
7Homologous recombination_Homo sapiens_hsa034403.05113506
8Base excision repair_Homo sapiens_hsa034103.05063827
9RNA polymerase_Homo sapiens_hsa030202.91996431
10Nucleotide excision repair_Homo sapiens_hsa034202.85228352
11One carbon pool by folate_Homo sapiens_hsa006702.78331652
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60638825
13Proteasome_Homo sapiens_hsa030502.57555416
14Fanconi anemia pathway_Homo sapiens_hsa034602.49813390
15Ribosome_Homo sapiens_hsa030102.38030441
16Pyrimidine metabolism_Homo sapiens_hsa002402.14003706
17Non-homologous end-joining_Homo sapiens_hsa034502.05701459
18Basal transcription factors_Homo sapiens_hsa030222.05367846
19mRNA surveillance pathway_Homo sapiens_hsa030152.04595882
20p53 signaling pathway_Homo sapiens_hsa041151.95268930
21RNA degradation_Homo sapiens_hsa030181.88223861
22Oocyte meiosis_Homo sapiens_hsa041141.59816789
23Systemic lupus erythematosus_Homo sapiens_hsa053221.55223966
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47959773
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36831029
26Vitamin B6 metabolism_Homo sapiens_hsa007501.31893965
27Pyruvate metabolism_Homo sapiens_hsa006201.25906464
28Epstein-Barr virus infection_Homo sapiens_hsa051691.24077076
29Viral carcinogenesis_Homo sapiens_hsa052031.21129853
30Purine metabolism_Homo sapiens_hsa002301.12395582
31MicroRNAs in cancer_Homo sapiens_hsa052061.00368154
32Biosynthesis of amino acids_Homo sapiens_hsa012300.94093981
33Steroid biosynthesis_Homo sapiens_hsa001000.91363165
34Selenocompound metabolism_Homo sapiens_hsa004500.89801950
35HTLV-I infection_Homo sapiens_hsa051660.88828773
36Herpes simplex infection_Homo sapiens_hsa051680.82330204
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81321482
38Hippo signaling pathway_Homo sapiens_hsa043900.81251460
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.80403085
40Antigen processing and presentation_Homo sapiens_hsa046120.79765954
41Small cell lung cancer_Homo sapiens_hsa052220.78458779
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78140216
43Pentose phosphate pathway_Homo sapiens_hsa000300.77127757
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76484526
45Basal cell carcinoma_Homo sapiens_hsa052170.71295303
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.69708259
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68665544
48TGF-beta signaling pathway_Homo sapiens_hsa043500.67639952
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66578712
50Thyroid cancer_Homo sapiens_hsa052160.65207620
51Alcoholism_Homo sapiens_hsa050340.62294116
52Fatty acid elongation_Homo sapiens_hsa000620.62147256
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58456114
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57197253
55Hedgehog signaling pathway_Homo sapiens_hsa043400.54968968
56Protein export_Homo sapiens_hsa030600.54172755
57Folate biosynthesis_Homo sapiens_hsa007900.53450567
58Adherens junction_Homo sapiens_hsa045200.51988216
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.51858254
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49359157
61Colorectal cancer_Homo sapiens_hsa052100.48956732
62Bladder cancer_Homo sapiens_hsa052190.47997471
63Carbon metabolism_Homo sapiens_hsa012000.47959720
64Galactose metabolism_Homo sapiens_hsa000520.47728997
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46833623
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45185841
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43044452
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42898961
69Legionellosis_Homo sapiens_hsa051340.42849566
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42786447
71Apoptosis_Homo sapiens_hsa042100.42383102
72Glutathione metabolism_Homo sapiens_hsa004800.41860506
73Chronic myeloid leukemia_Homo sapiens_hsa052200.41815621
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40262980
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.39915846
76Notch signaling pathway_Homo sapiens_hsa043300.39835229
77Tight junction_Homo sapiens_hsa045300.37766014
78Propanoate metabolism_Homo sapiens_hsa006400.35780919
79mTOR signaling pathway_Homo sapiens_hsa041500.35144695
80Shigellosis_Homo sapiens_hsa051310.34485728
81HIF-1 signaling pathway_Homo sapiens_hsa040660.34083188
82Pathways in cancer_Homo sapiens_hsa052000.34050403
83Viral myocarditis_Homo sapiens_hsa054160.33015924
84ECM-receptor interaction_Homo sapiens_hsa045120.32875346
85Hepatitis B_Homo sapiens_hsa051610.31340464
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29965220
87Sulfur relay system_Homo sapiens_hsa041220.29867005
88Prostate cancer_Homo sapiens_hsa052150.29487167
89Proteoglycans in cancer_Homo sapiens_hsa052050.29110828
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28785189
91Lysine degradation_Homo sapiens_hsa003100.26019060
92Fructose and mannose metabolism_Homo sapiens_hsa000510.25698093
93Arginine and proline metabolism_Homo sapiens_hsa003300.23857655
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23088613
95Metabolic pathways_Homo sapiens_hsa011000.22225156
96Wnt signaling pathway_Homo sapiens_hsa043100.22137799
97Glioma_Homo sapiens_hsa052140.21933176
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21903553
99Focal adhesion_Homo sapiens_hsa045100.21614549
100FoxO signaling pathway_Homo sapiens_hsa040680.21398519
101Gap junction_Homo sapiens_hsa045400.21167180
102Arginine biosynthesis_Homo sapiens_hsa002200.21117262
103Melanoma_Homo sapiens_hsa052180.21011939
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19190604
105AMPK signaling pathway_Homo sapiens_hsa041520.18985410
106Non-small cell lung cancer_Homo sapiens_hsa052230.16545075
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15870250
108Renin-angiotensin system_Homo sapiens_hsa046140.15461558
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15270705
110Influenza A_Homo sapiens_hsa051640.15017422
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.14399295
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13386483
113N-Glycan biosynthesis_Homo sapiens_hsa005100.13359061
114Pancreatic cancer_Homo sapiens_hsa052120.12566680
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11833431
116Endometrial cancer_Homo sapiens_hsa052130.10579751
117Huntingtons disease_Homo sapiens_hsa050160.09985460
118Measles_Homo sapiens_hsa051620.09590396
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.09123359
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08477008

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