KIF20B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.77302680
2kinetochore organization (GO:0051383)5.60241690
3mitotic metaphase plate congression (GO:0007080)5.45945864
4mitotic chromosome condensation (GO:0007076)5.18691330
5nuclear pore complex assembly (GO:0051292)5.15143839
6nuclear pore organization (GO:0006999)5.10399229
7protein localization to chromosome, centromeric region (GO:0071459)5.05890137
8metaphase plate congression (GO:0051310)5.01429962
9mitotic sister chromatid segregation (GO:0000070)4.96363610
10sister chromatid segregation (GO:0000819)4.82288054
11attachment of spindle microtubules to kinetochore (GO:0008608)4.80611118
12kinetochore assembly (GO:0051382)4.77956494
13chromatin remodeling at centromere (GO:0031055)4.72667814
14CENP-A containing nucleosome assembly (GO:0034080)4.70263974
15meiotic chromosome segregation (GO:0045132)4.63250420
16regulation of spindle organization (GO:0090224)4.60938349
17establishment of chromosome localization (GO:0051303)4.54449260
18DNA unwinding involved in DNA replication (GO:0006268)4.49971369
19mitotic nuclear envelope disassembly (GO:0007077)4.35368599
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.34848998
21DNA ligation (GO:0006266)4.33266264
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33080441
23DNA replication-independent nucleosome organization (GO:0034724)4.29681959
24DNA replication-independent nucleosome assembly (GO:0006336)4.29681959
25DNA replication-dependent nucleosome assembly (GO:0006335)4.27797742
26DNA replication-dependent nucleosome organization (GO:0034723)4.27797742
27regulation of mitotic spindle organization (GO:0060236)4.25446879
28DNA replication initiation (GO:0006270)4.16904644
29DNA replication checkpoint (GO:0000076)4.15986518
30DNA strand elongation involved in DNA replication (GO:0006271)4.15408769
31mitotic sister chromatid cohesion (GO:0007064)4.14367708
32histone exchange (GO:0043486)4.07445380
33membrane disassembly (GO:0030397)4.04951357
34nuclear envelope disassembly (GO:0051081)4.04951357
35establishment of integrated proviral latency (GO:0075713)4.04028055
36pore complex assembly (GO:0046931)4.01203132
37spindle checkpoint (GO:0031577)3.97042885
38mitotic recombination (GO:0006312)3.96529530
39DNA strand elongation (GO:0022616)3.95946997
40telomere maintenance via semi-conservative replication (GO:0032201)3.95040243
41positive regulation of chromosome segregation (GO:0051984)3.92422695
42telomere maintenance via recombination (GO:0000722)3.83206145
43regulation of chromosome segregation (GO:0051983)3.81901668
44protein localization to chromosome (GO:0034502)3.81819986
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.80349762
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.80349762
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.80349762
48chromosome segregation (GO:0007059)3.77931827
49spindle assembly checkpoint (GO:0071173)3.74633610
50regulation of mitotic metaphase/anaphase transition (GO:0030071)3.74543695
51replication fork processing (GO:0031297)3.74336270
52negative regulation of chromosome segregation (GO:0051985)3.69717928
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.67146936
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.67146936
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.67146936
56negative regulation of sister chromatid segregation (GO:0033046)3.67146936
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.66828174
58regulation of centrosome cycle (GO:0046605)3.65338428
59mitotic spindle checkpoint (GO:0071174)3.61472870
60chromatin assembly or disassembly (GO:0006333)3.61440083
61protein K6-linked ubiquitination (GO:0085020)3.60228955
62mitotic spindle assembly checkpoint (GO:0007094)3.59442527
63double-strand break repair via nonhomologous end joining (GO:0006303)3.58641191
64non-recombinational repair (GO:0000726)3.58641191
65regulation of mitotic sister chromatid segregation (GO:0033047)3.57476740
66regulation of sister chromatid segregation (GO:0033045)3.57476740
67regulation of mitotic sister chromatid separation (GO:0010965)3.57476740
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.57379696
69DNA duplex unwinding (GO:0032508)3.56242732
70DNA geometric change (GO:0032392)3.56162633
71centriole replication (GO:0007099)3.55030078
72DNA topological change (GO:0006265)3.54404874
73negative regulation of mitosis (GO:0045839)3.53768035
74regulation of centriole replication (GO:0046599)3.52165712
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51800158
76regulation of mitotic spindle checkpoint (GO:1903504)3.51800158
77regulation of sister chromatid cohesion (GO:0007063)3.50552503
78DNA double-strand break processing (GO:0000729)3.50293088
79chromosome condensation (GO:0030261)3.48077241
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44080064
81regulation of histone H3-K9 methylation (GO:0051570)3.43910515
82synapsis (GO:0007129)3.42163628
83microtubule depolymerization (GO:0007019)3.42139073
84telomere maintenance via telomere lengthening (GO:0010833)3.41290662
85nucleobase biosynthetic process (GO:0046112)3.34778220
86resolution of meiotic recombination intermediates (GO:0000712)3.32400593
87ATP-dependent chromatin remodeling (GO:0043044)3.32340722
88IMP biosynthetic process (GO:0006188)3.31415439
89mitotic G2 DNA damage checkpoint (GO:0007095)3.30544180
90DNA conformation change (GO:0071103)3.28915422
91DNA packaging (GO:0006323)3.24225782
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.23842787
93somatic hypermutation of immunoglobulin genes (GO:0016446)3.20564721
94somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20564721
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19377684
96negative regulation of DNA recombination (GO:0045910)3.19258252
97negative regulation of DNA-dependent DNA replication (GO:2000104)3.15098966
98regulation of double-strand break repair via homologous recombination (GO:0010569)3.15037995
99negative regulation of nuclear division (GO:0051784)3.13862708
100purine nucleobase biosynthetic process (GO:0009113)3.11520307
101negative regulation of cell division (GO:0051782)3.10586812
102folic acid-containing compound biosynthetic process (GO:0009396)3.09848564
103negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.09058837
104histone-serine phosphorylation (GO:0035404)3.09055470
105negative regulation of histone methylation (GO:0031061)3.08584871
106nuclear envelope organization (GO:0006998)3.07262584
107telomere maintenance (GO:0000723)3.06785937
108mitotic G2/M transition checkpoint (GO:0044818)3.06204762
109regulation of helicase activity (GO:0051095)3.05449258
110regulation of telomere maintenance via telomerase (GO:0032210)3.05407429
111telomere organization (GO:0032200)3.04952482
112regulation of DNA endoreduplication (GO:0032875)3.04893997
113maturation of SSU-rRNA (GO:0030490)3.04338193
114regulation of nuclear cell cycle DNA replication (GO:0033262)3.02473942
115regulation of centrosome duplication (GO:0010824)3.02316502
116IMP metabolic process (GO:0046040)3.01861273
117mismatch repair (GO:0006298)3.01159361
118mitotic cell cycle (GO:0000278)2.98081411

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.52154538
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.86899801
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.12804890
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.72446708
5AR_21909140_ChIP-Seq_LNCAP_Human2.74996602
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69930930
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63490167
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.62659266
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59704953
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.59579275
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57278617
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55841614
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.42437298
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.36840447
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32958992
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26931929
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20504855
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15601780
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03175259
20E2F7_22180533_ChIP-Seq_HELA_Human10.5735515
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.99042301
22* XRN2_22483619_ChIP-Seq_HELA_Human1.98327146
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.97986377
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.92434957
25VDR_23849224_ChIP-Seq_CD4+_Human1.88488226
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85687394
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84510182
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83867807
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78550191
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74943911
31FOXP3_21729870_ChIP-Seq_TREG_Human1.72726864
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71817911
33ELK1_19687146_ChIP-ChIP_HELA_Human1.70475231
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69517538
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69393425
36EWS_26573619_Chip-Seq_HEK293_Human1.67729783
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65570504
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62366442
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61397141
40* TTF2_22483619_ChIP-Seq_HELA_Human1.54604459
41DCP1A_22483619_ChIP-Seq_HELA_Human1.54457146
42FUS_26573619_Chip-Seq_HEK293_Human1.51182442
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.44688915
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41833762
45CIITA_25753668_ChIP-Seq_RAJI_Human1.41226953
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40548931
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40314080
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37827039
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37023057
50* GABP_19822575_ChIP-Seq_HepG2_Human1.36929645
51KDM5A_27292631_Chip-Seq_BREAST_Human1.36866983
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35269057
53MYC_22102868_ChIP-Seq_BL_Human1.33965867
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33317225
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32528427
56* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30817498
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30358809
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28540169
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26929641
60NANOG_16153702_ChIP-ChIP_HESCs_Human1.26689192
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23887483
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22627691
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22310109
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21799322
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20118696
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19007525
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16761075
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15780892
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.12675430
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11253002
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09022626
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07864019
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03693208
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03430499
75TFEB_21752829_ChIP-Seq_HELA_Human1.01192370
76CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01079737
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99691495
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99507935
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98263423
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98263423
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98263423
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95568493
83YY1_21170310_ChIP-Seq_MESCs_Mouse0.94648005
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93629054
85SOX17_20123909_ChIP-Seq_XEN_Mouse0.92941464
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.91856275
87* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90799872
88NOTCH1_21737748_ChIP-Seq_TLL_Human0.90018208
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89186268
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88784369
91* MYC_18940864_ChIP-ChIP_HL60_Human0.88155437
92TAF15_26573619_Chip-Seq_HEK293_Human0.88037198
93VDR_22108803_ChIP-Seq_LS180_Human0.88012777
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87349283
95IRF1_19129219_ChIP-ChIP_H3396_Human0.86909270
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83310441
97TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82368623
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82246835
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81792966
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81516916
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81278428
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80289766
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80021080
104SRF_21415370_ChIP-Seq_HL-1_Mouse0.77527532
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76855890
106* SPI1_23547873_ChIP-Seq_NB4_Human0.74921038
107TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74543006
108NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73491171
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72683781
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72220770
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72155535
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.72132636
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.71789159
114ZNF274_21170338_ChIP-Seq_K562_Hela0.69845043
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.68674248
116FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67702908
117P300_19829295_ChIP-Seq_ESCs_Human0.66111152
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.64511541
119HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.64123352
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.64034992
121GATA1_26923725_Chip-Seq_HPCs_Mouse0.63813330
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.63133276
123WT1_19549856_ChIP-ChIP_CCG9911_Human0.62765250
124TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62327490
125CHD1_26751641_Chip-Seq_LNCaP_Human0.61792068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.42432597
2MP0010094_abnormal_chromosome_stability5.13790893
3MP0003111_abnormal_nucleus_morphology4.71411838
4MP0004957_abnormal_blastocyst_morpholog4.26884756
5MP0008057_abnormal_DNA_replication4.24739877
6MP0003077_abnormal_cell_cycle4.21565222
7MP0008058_abnormal_DNA_repair3.29924834
8MP0008007_abnormal_cellular_replicative2.94071281
9MP0008877_abnormal_DNA_methylation2.74790807
10MP0010307_abnormal_tumor_latency2.59612513
11MP0008932_abnormal_embryonic_tissue2.55888247
12MP0003123_paternal_imprinting2.45853102
13MP0001730_embryonic_growth_arrest2.39539478
14MP0000350_abnormal_cell_proliferation2.36477850
15MP0002396_abnormal_hematopoietic_system2.33575107
16MP0010352_gastrointestinal_tract_polyps2.28703259
17MP0003786_premature_aging1.95916094
18MP0001672_abnormal_embryogenesis/_devel1.89480012
19MP0005380_embryogenesis_phenotype1.89480012
20MP0001697_abnormal_embryo_size1.82956528
21MP0003121_genomic_imprinting1.72715602
22MP0005076_abnormal_cell_differentiation1.68684497
23MP0002085_abnormal_embryonic_tissue1.67686248
24MP0003984_embryonic_growth_retardation1.67514278
25MP0002088_abnormal_embryonic_growth/wei1.63604200
26MP0002084_abnormal_developmental_patter1.62944584
27MP0002086_abnormal_extraembryonic_tissu1.59838756
28MP0004808_abnormal_hematopoietic_stem1.57837293
29MP0004197_abnormal_fetal_growth/weight/1.57791806
30MP0002080_prenatal_lethality1.56390943
31MP0000490_abnormal_crypts_of1.56117546
32MP0003718_maternal_effect1.51182951
33MP0000313_abnormal_cell_death1.43011681
34MP0002210_abnormal_sex_determination1.37892800
35MP0002019_abnormal_tumor_incidence1.37446400
36MP0003890_abnormal_embryonic-extraembry1.30814165
37MP0003567_abnormal_fetal_cardiomyocyte1.30501926
38MP0001293_anophthalmia1.27713490
39MP0001145_abnormal_male_reproductive1.19313198
40MP0003705_abnormal_hypodermis_morpholog1.15121221
41MP0001929_abnormal_gametogenesis1.14521191
42MP0002938_white_spotting1.12555981
43MP0003136_yellow_coat_color1.11117904
44MP0003937_abnormal_limbs/digits/tail_de1.09052623
45MP0002233_abnormal_nose_morphology1.08543895
46MP0003315_abnormal_perineum_morphology1.07463913
47MP0000653_abnormal_sex_gland1.06238234
48MP0009672_abnormal_birth_weight1.01719545
49MP0003941_abnormal_skin_development1.01259623
50MP0010030_abnormal_orbit_morphology1.00625647
51MP0000703_abnormal_thymus_morphology1.00456671
52MP0001545_abnormal_hematopoietic_system0.99974657
53MP0005397_hematopoietic_system_phenotyp0.99974657
54MP0009053_abnormal_anal_canal0.97620873
55MP0003787_abnormal_imprinting0.97377801
56MP0009703_decreased_birth_body0.96497054
57MP0003566_abnormal_cell_adhesion0.96454864
58MP0006035_abnormal_mitochondrial_morpho0.93928396
59MP0000569_abnormal_digit_pigmentation0.92282846
60MP0008789_abnormal_olfactory_epithelium0.92155585
61MP0001188_hyperpigmentation0.92093706
62MP0001119_abnormal_female_reproductive0.90491027
63MP0005395_other_phenotype0.88793964
64MP0001915_intracranial_hemorrhage0.87578379
65MP0002398_abnormal_bone_marrow0.86566052
66MP0000358_abnormal_cell_content/0.86330113
67MP0005621_abnormal_cell_physiology0.83428696
68MP0002722_abnormal_immune_system0.82512041
69MP0002111_abnormal_tail_morphology0.81552455
70MP0000647_abnormal_sebaceous_gland0.80920910
71MP0002234_abnormal_pharynx_morphology0.80515746
72MP0005384_cellular_phenotype0.80167496
73MP0005023_abnormal_wound_healing0.79794736
74MP0000537_abnormal_urethra_morphology0.78851580
75MP0004264_abnormal_extraembryonic_tissu0.78850645
76MP0005499_abnormal_olfactory_system0.78543220
77MP0005394_taste/olfaction_phenotype0.78543220
78MP0006072_abnormal_retinal_apoptosis0.77286586
79MP0003763_abnormal_thymus_physiology0.75918130
80MP0000689_abnormal_spleen_morphology0.75818556
81MP0003861_abnormal_nervous_system0.75334353
82MP0003119_abnormal_digestive_system0.74953027
83MP0002092_abnormal_eye_morphology0.74755706
84MP0000432_abnormal_head_morphology0.74014662
85MP0006054_spinal_hemorrhage0.73968693
86MP0006292_abnormal_olfactory_placode0.72992072
87MP0003950_abnormal_plasma_membrane0.72697950
88MP0002009_preneoplasia0.72203781
89MP0000579_abnormal_nail_morphology0.71785112
90MP0000049_abnormal_middle_ear0.71529878
91MP0001286_abnormal_eye_development0.70634374
92MP0001529_abnormal_vocalization0.70562002
93MP0000858_altered_metastatic_potential0.69391872
94MP0001346_abnormal_lacrimal_gland0.68789364
95MP0000427_abnormal_hair_cycle0.67822513
96MP0000428_abnormal_craniofacial_morphol0.67581057
97MP0002102_abnormal_ear_morphology0.67373834
98MP0000372_irregular_coat_pigmentation0.66367423
99MP0001849_ear_inflammation0.66231107
100MP0009333_abnormal_splenocyte_physiolog0.66127568
101MP0000733_abnormal_muscle_development0.65188469
102MP0009278_abnormal_bone_marrow0.64929084
103MP0001177_atelectasis0.64628613
104MP0002697_abnormal_eye_size0.64313632
105MP0003943_abnormal_hepatobiliary_system0.64238862
106MP0002006_tumorigenesis0.63977880
107MP0005408_hypopigmentation0.63824174
108MP0000762_abnormal_tongue_morphology0.62938929
109MP0005391_vision/eye_phenotype0.62894925
110MP0000477_abnormal_intestine_morphology0.61062841
111MP0002160_abnormal_reproductive_system0.60581702
112MP0002429_abnormal_blood_cell0.60370305
113MP0003806_abnormal_nucleotide_metabolis0.60235617
114MP0003448_altered_tumor_morphology0.60189891
115MP0002877_abnormal_melanocyte_morpholog0.60024169
116MP0003385_abnormal_body_wall0.59825436
117MP0002925_abnormal_cardiovascular_devel0.59764699
118MP0003935_abnormal_craniofacial_develop0.59685653
119MP0003221_abnormal_cardiomyocyte_apopto0.59467049
120MP0009250_abnormal_appendicular_skeleto0.58771617
121MP0003115_abnormal_respiratory_system0.57925746
122MP0005389_reproductive_system_phenotype0.57465675
123MP0003699_abnormal_female_reproductive0.57246347
124MP0003698_abnormal_male_reproductive0.56354617
125MP0002095_abnormal_skin_pigmentation0.55499620
126MP0004185_abnormal_adipocyte_glucose0.54052008
127MP0003755_abnormal_palate_morphology0.53827003
128MP0002653_abnormal_ependyma_morphology0.53812587
129MP0008995_early_reproductive_senescence0.53150167
130MP0004133_heterotaxia0.52132386
131MP0002075_abnormal_coat/hair_pigmentati0.51769719
132MP0009697_abnormal_copulation0.51590737
133MP0002161_abnormal_fertility/fecundity0.51531685

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.45828312
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.98470938
3Abnormality of chromosome stability (HP:0003220)4.17061889
4Birth length less than 3rd percentile (HP:0003561)3.87436474
5Volvulus (HP:0002580)3.61634516
6Medulloblastoma (HP:0002885)3.58693327
7Meckel diverticulum (HP:0002245)3.50294190
8Reticulocytopenia (HP:0001896)3.42885346
9Abnormality of the preputium (HP:0100587)3.42427674
10Impulsivity (HP:0100710)3.40283637
11Ependymoma (HP:0002888)3.37070626
12Cortical dysplasia (HP:0002539)3.34056780
13Colon cancer (HP:0003003)3.34035484
14Abnormality of the ileum (HP:0001549)3.31523307
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.31115136
16Abnormality of the labia minora (HP:0012880)3.23987727
17Selective tooth agenesis (HP:0001592)3.20962847
18Patellar aplasia (HP:0006443)3.11702161
19Duodenal stenosis (HP:0100867)3.08040378
20Small intestinal stenosis (HP:0012848)3.08040378
21Myelodysplasia (HP:0002863)3.04659927
22Ectopic kidney (HP:0000086)3.01392745
23Breast hypoplasia (HP:0003187)3.00636614
24Aplasia/Hypoplasia of the patella (HP:0006498)2.93820832
25Rhabdomyosarcoma (HP:0002859)2.90155242
26Increased nuchal translucency (HP:0010880)2.88536036
27Absent radius (HP:0003974)2.87644590
28Agnosia (HP:0010524)2.84712525
29Nephroblastoma (Wilms tumor) (HP:0002667)2.75589092
30Carpal bone hypoplasia (HP:0001498)2.74931843
31Abnormality of the anterior horn cell (HP:0006802)2.74382805
32Degeneration of anterior horn cells (HP:0002398)2.74382805
33Proximal placement of thumb (HP:0009623)2.70977664
34Deviation of the thumb (HP:0009603)2.70143824
35Aplasia involving forearm bones (HP:0009822)2.66753237
36Absent forearm bone (HP:0003953)2.66753237
37Sloping forehead (HP:0000340)2.66198164
3811 pairs of ribs (HP:0000878)2.65639278
39Absent thumb (HP:0009777)2.63373690
40Abnormal lung lobation (HP:0002101)2.60840804
41Facial hemangioma (HP:0000329)2.60323863
42Supernumerary spleens (HP:0009799)2.58513672
43Embryonal renal neoplasm (HP:0011794)2.57404336
44Abnormality of the astrocytes (HP:0100707)2.51203739
45Astrocytoma (HP:0009592)2.51203739
46Duplicated collecting system (HP:0000081)2.50940625
47Abnormality of the duodenum (HP:0002246)2.50418776
48Cafe-au-lait spot (HP:0000957)2.40756713
49Oral leukoplakia (HP:0002745)2.37577286
50Glioma (HP:0009733)2.37528189
51Abnormality of the carotid arteries (HP:0005344)2.36375986
52Prominent nose (HP:0000448)2.34483015
53Embryonal neoplasm (HP:0002898)2.33742767
54Biliary tract neoplasm (HP:0100574)2.32244252
55Basal cell carcinoma (HP:0002671)2.32206358
56Bone marrow hypocellularity (HP:0005528)2.31895757
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29350921
58Abnormal number of incisors (HP:0011064)2.28593962
59Short thumb (HP:0009778)2.28534959
60Neoplasm of the oral cavity (HP:0100649)2.28233650
61Squamous cell carcinoma (HP:0002860)2.28047492
62Septo-optic dysplasia (HP:0100842)2.27117372
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26519869
64Short 4th metacarpal (HP:0010044)2.26519869
65Neoplasm of the pancreas (HP:0002894)2.20479705
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.20222164
67Clubbing of toes (HP:0100760)2.19460534
68Abnormality of the renal collecting system (HP:0004742)2.19392511
69Missing ribs (HP:0000921)2.18143245
70High pitched voice (HP:0001620)2.18100466
71Horseshoe kidney (HP:0000085)2.15220807
72Aplastic anemia (HP:0001915)2.11990414
73Oligodactyly (hands) (HP:0001180)2.10881046
74Abnormal auditory evoked potentials (HP:0006958)2.09701383
75Neoplasm of the colon (HP:0100273)2.09385948
76Tracheoesophageal fistula (HP:0002575)2.07555765
77Neoplasm of striated muscle (HP:0009728)2.06599514
78Abnormality of DNA repair (HP:0003254)2.06269602
79Sandal gap (HP:0001852)2.04945838
80Atresia of the external auditory canal (HP:0000413)2.04362930
81Acute myeloid leukemia (HP:0004808)2.03676048
82Amaurosis fugax (HP:0100576)2.03453388
83Abnormality of the septum pellucidum (HP:0007375)2.03412052
84Premature graying of hair (HP:0002216)2.02492510
85Multiple enchondromatosis (HP:0005701)2.00941349
86Pancreatic islet-cell hyperplasia (HP:0004510)2.00133180
87Rough bone trabeculation (HP:0100670)1.97217531
88Deep philtrum (HP:0002002)1.96922628
89Long eyelashes (HP:0000527)1.94225630
90Triphalangeal thumb (HP:0001199)1.91624768
91Absent septum pellucidum (HP:0001331)1.90529867
92Hypoplasia of the pons (HP:0012110)1.89650799
93Bifid tongue (HP:0010297)1.87167806
94Abnormality of the pons (HP:0007361)1.87018999
95Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86519753
96Aplasia/hypoplasia of the humerus (HP:0006507)1.84870814
97Abnormal spermatogenesis (HP:0008669)1.84736608
98Malignant gastrointestinal tract tumors (HP:0006749)1.84005423
99Gastrointestinal carcinoma (HP:0002672)1.84005423
100Ovarian neoplasm (HP:0100615)1.77989189
101Ankle contracture (HP:0006466)1.77931623
102Abnormality of the fingertips (HP:0001211)1.76952376
103Abnormality of abdominal situs (HP:0011620)1.73831867
104Abdominal situs inversus (HP:0003363)1.73831867
105Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72576275
106Duplication of thumb phalanx (HP:0009942)1.71863892
107Choanal atresia (HP:0000453)1.71740992
108Blepharitis (HP:0000498)1.71497670
109Arteriovenous malformation (HP:0100026)1.69901771
110Cellular immunodeficiency (HP:0005374)1.69661857
111Progressive external ophthalmoplegia (HP:0000590)1.69480033
112Abnormality of chromosome segregation (HP:0002916)1.66170587
113Rib fusion (HP:0000902)1.65300907
114Small hand (HP:0200055)1.64988523
115Abnormality of methionine metabolism (HP:0010901)1.64938465
116Short humerus (HP:0005792)1.63612211
117Lymphoma (HP:0002665)1.62960657
118Neoplasm of the small intestine (HP:0100833)1.62643528
119Intestinal atresia (HP:0011100)1.62180561
120Overlapping toe (HP:0001845)1.59135039
121Oligohydramnios (HP:0001562)1.58691429
122Abnormal umbilical cord blood vessels (HP:0011403)1.58129540
123Single umbilical artery (HP:0001195)1.58129540
124Abnormality of the fetal cardiovascular system (HP:0010948)1.58129540
125Uterine neoplasm (HP:0010784)1.54652642
126Hypoplastic pelvis (HP:0008839)1.54523099
127Myelomeningocele (HP:0002475)1.54353226
128Increased hepatocellular lipid droplets (HP:0006565)1.53180757
129Gastrointestinal atresia (HP:0002589)1.52808421
130Median cleft lip (HP:0000161)1.52179997
131Papillary thyroid carcinoma (HP:0002895)1.52022754
132Astigmatism (HP:0000483)1.51329039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.28383705
2WEE14.21390396
3BUB14.00692649
4NEK23.48034868
5TTK3.11560760
6BRSK22.98165939
7SRPK12.76393945
8CDK122.76165310
9NEK12.60544291
10EIF2AK12.53005124
11PLK12.41468187
12PLK42.35295044
13AURKB2.10847169
14PLK32.07156442
15MKNK12.05306459
16ATR1.92705146
17MST41.91458757
18CHEK21.84483020
19ACVR1B1.82422699
20BMPR1B1.72944084
21TNIK1.69597046
22BRSK11.68276438
23TSSK61.67436523
24VRK21.66020491
25TAF11.59249168
26TRIM281.58954063
27CDK71.58438322
28STK101.56195728
29MKNK21.53529529
30CHEK11.53473108
31STK41.53447372
32RPS6KB21.48676587
33VRK11.46690476
34TLK11.42912642
35CDK41.42801739
36MAP3K81.42298597
37PASK1.39984496
38EIF2AK31.35616919
39ZAK1.29236740
40EEF2K1.26723337
41ATM1.25595165
42RPS6KA41.25095093
43BRD41.23007514
44AURKA1.19547787
45CDK61.13626448
46STK31.11199236
47CCNB11.11140612
48LATS11.04294406
49EPHA21.03661005
50MELK1.02566832
51TESK21.01285334
52CDK20.99616206
53DYRK30.93470205
54SCYL20.92564560
55EIF2AK20.87373918
56* CDK10.84640185
57PIM10.82214075
58PNCK0.79216329
59ALK0.78621588
60WNK30.78397737
61ERBB40.78251668
62PAK40.77199249
63STK38L0.76767454
64PLK20.74402291
65TGFBR10.72249318
66PBK0.71265863
67FLT30.63866656
68NME20.63096400
69STK160.61185470
70CLK10.60324561
71PKN20.58745672
72CSNK2A20.58012679
73CDK80.56898778
74NUAK10.55594504
75BCR0.55426396
76CSNK2A10.53021263
77PRKDC0.49352209
78MTOR0.48594484
79CDK30.47850248
80MAP3K100.47804140
81RPS6KA50.47051413
82PAK10.45794249
83BRAF0.45315187
84MARK30.45126674
85MET0.44849806
86PDK20.42759401
87LATS20.42558420
88CSNK1G10.41028609
89CSNK1D0.40991976
90MAPK140.40723434
91PRKCI0.39909223
92TTN0.38825996
93CDK90.38597586
94NLK0.38125984
95STK240.37503192
96NME10.37396731
97CSNK1E0.36984083
98STK390.35928992
99LRRK20.35239527
100TEC0.34508632
101MST1R0.34470426
102NEK90.33190712
103MAP4K10.32987277
104AKT10.31586255
105NEK60.30952710
106AKT20.27566386
107CAMK1G0.26792013
108MAPK10.26567742
109GSK3B0.25148840
110TESK10.23540085
111TRPM70.22787326
112PAK20.21714896
113CHUK0.21652185
114FGFR10.20267203
115JAK30.20136096
116ERBB30.20030021
117CDK180.19771734
118YES10.18761406
119RPS6KB10.17672297
120DMPK0.17446411
121CDK150.15635722
122PRKACB0.14345156
123BTK0.14112986
124PDK40.12336491
125PDK30.12336491
126CAMK1D0.09952416

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79082756
2Mismatch repair_Homo sapiens_hsa034304.49283423
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68379670
4Homologous recombination_Homo sapiens_hsa034403.49751064
5Cell cycle_Homo sapiens_hsa041103.41875401
6RNA transport_Homo sapiens_hsa030133.26950339
7Spliceosome_Homo sapiens_hsa030403.20478261
8Base excision repair_Homo sapiens_hsa034103.02158782
9Fanconi anemia pathway_Homo sapiens_hsa034602.94667260
10Nucleotide excision repair_Homo sapiens_hsa034202.86531781
11Non-homologous end-joining_Homo sapiens_hsa034502.71106947
12One carbon pool by folate_Homo sapiens_hsa006702.70757687
13RNA polymerase_Homo sapiens_hsa030202.54231036
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28744626
15RNA degradation_Homo sapiens_hsa030182.19982324
16Ribosome_Homo sapiens_hsa030102.18211566
17mRNA surveillance pathway_Homo sapiens_hsa030152.08713429
18Basal transcription factors_Homo sapiens_hsa030222.07086492
19Pyrimidine metabolism_Homo sapiens_hsa002402.00053833
20p53 signaling pathway_Homo sapiens_hsa041151.96306520
21Systemic lupus erythematosus_Homo sapiens_hsa053221.93601625
22Proteasome_Homo sapiens_hsa030501.87590374
23Protein export_Homo sapiens_hsa030601.79272327
24Oocyte meiosis_Homo sapiens_hsa041141.38082979
25Viral carcinogenesis_Homo sapiens_hsa052031.31711079
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29368759
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27572851
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25482625
29Epstein-Barr virus infection_Homo sapiens_hsa051691.17645499
30Steroid biosynthesis_Homo sapiens_hsa001001.16744545
31Pyruvate metabolism_Homo sapiens_hsa006201.13144159
32MicroRNAs in cancer_Homo sapiens_hsa052061.10744463
33Herpes simplex infection_Homo sapiens_hsa051681.08533737
34Propanoate metabolism_Homo sapiens_hsa006401.08528916
35Purine metabolism_Homo sapiens_hsa002301.03952168
36Antigen processing and presentation_Homo sapiens_hsa046121.03912552
37HTLV-I infection_Homo sapiens_hsa051660.91630717
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90662187
39Selenocompound metabolism_Homo sapiens_hsa004500.88854034
40Small cell lung cancer_Homo sapiens_hsa052220.88027224
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77814236
42Alcoholism_Homo sapiens_hsa050340.77295954
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74756692
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74405892
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73265323
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72858437
47Huntingtons disease_Homo sapiens_hsa050160.72153544
48Thyroid cancer_Homo sapiens_hsa052160.71316270
49TGF-beta signaling pathway_Homo sapiens_hsa043500.65456940
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64755363
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63908011
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61354061
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61051713
54Colorectal cancer_Homo sapiens_hsa052100.59433245
55Parkinsons disease_Homo sapiens_hsa050120.58896336
56Vitamin B6 metabolism_Homo sapiens_hsa007500.56698659
57Lysine degradation_Homo sapiens_hsa003100.55557265
58Pentose phosphate pathway_Homo sapiens_hsa000300.54473655
59Hippo signaling pathway_Homo sapiens_hsa043900.52917967
60Fatty acid elongation_Homo sapiens_hsa000620.51097260
61Apoptosis_Homo sapiens_hsa042100.50880953
62Adherens junction_Homo sapiens_hsa045200.50622434
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49551350
64Chronic myeloid leukemia_Homo sapiens_hsa052200.48542423
65Hepatitis B_Homo sapiens_hsa051610.48216674
66Carbon metabolism_Homo sapiens_hsa012000.48209117
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.47430640
68Biosynthesis of amino acids_Homo sapiens_hsa012300.47123666
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.46970975
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.45706753
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44047844
72Primary immunodeficiency_Homo sapiens_hsa053400.43688495
73Basal cell carcinoma_Homo sapiens_hsa052170.43233303
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42333611
75Measles_Homo sapiens_hsa051620.42164019
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41412250
77Legionellosis_Homo sapiens_hsa051340.41239873
78Notch signaling pathway_Homo sapiens_hsa043300.40459057
79Oxidative phosphorylation_Homo sapiens_hsa001900.39893748
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.39812843
81Pathways in cancer_Homo sapiens_hsa052000.38746265
82Pancreatic cancer_Homo sapiens_hsa052120.38093248
83Prostate cancer_Homo sapiens_hsa052150.37659555
84Influenza A_Homo sapiens_hsa051640.37654267
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36564447
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36046438
87Viral myocarditis_Homo sapiens_hsa054160.34785722
88mTOR signaling pathway_Homo sapiens_hsa041500.32390525
89Metabolic pathways_Homo sapiens_hsa011000.31053964
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30032453
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29256710
92FoxO signaling pathway_Homo sapiens_hsa040680.28516297
93Non-small cell lung cancer_Homo sapiens_hsa052230.27878775
94Bladder cancer_Homo sapiens_hsa052190.27182084
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26449244
96HIF-1 signaling pathway_Homo sapiens_hsa040660.25389432
97Shigellosis_Homo sapiens_hsa051310.24836113
98Hematopoietic cell lineage_Homo sapiens_hsa046400.24749723
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24284103
100Fatty acid metabolism_Homo sapiens_hsa012120.23524858
101Glutathione metabolism_Homo sapiens_hsa004800.22604203
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.22303141
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.22149109
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.21967897
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21908705
106Melanoma_Homo sapiens_hsa052180.21584890
107Proteoglycans in cancer_Homo sapiens_hsa052050.21078971
108Renin-angiotensin system_Homo sapiens_hsa046140.21063261
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19657593
110Folate biosynthesis_Homo sapiens_hsa007900.19187296
111Vitamin digestion and absorption_Homo sapiens_hsa049770.18719411
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.18709779
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17968285
114Endometrial cancer_Homo sapiens_hsa052130.16069181
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15925247
116Wnt signaling pathway_Homo sapiens_hsa043100.15702813
117Tight junction_Homo sapiens_hsa045300.15516126
118Hedgehog signaling pathway_Homo sapiens_hsa043400.15042586
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14351211
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14047838
121Alzheimers disease_Homo sapiens_hsa050100.13967646
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13917640
123Fatty acid biosynthesis_Homo sapiens_hsa000610.13773435
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13759237
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13310323
126N-Glycan biosynthesis_Homo sapiens_hsa005100.13038347
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11186670
128Acute myeloid leukemia_Homo sapiens_hsa052210.10149795
129B cell receptor signaling pathway_Homo sapiens_hsa046620.09906732
130Fatty acid degradation_Homo sapiens_hsa000710.09350688
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08609776
132Olfactory transduction_Homo sapiens_hsa047400.01105424
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0034656
134Sulfur relay system_Homo sapiens_hsa04122-0.0018988

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »