

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of cell killing (GO:0031342) | 6.62216012 |
| 2 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.62216012 |
| 3 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.17604413 |
| 4 | layer formation in cerebral cortex (GO:0021819) | 4.89440783 |
| 5 | synaptic vesicle maturation (GO:0016188) | 4.29666495 |
| 6 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.26600621 |
| 7 | nucleobase catabolic process (GO:0046113) | 4.23161825 |
| 8 | locomotory exploration behavior (GO:0035641) | 4.21212484 |
| 9 | negative T cell selection (GO:0043383) | 4.12319596 |
| 10 | negative thymic T cell selection (GO:0045060) | 3.96167861 |
| 11 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.93262036 |
| 12 | positive T cell selection (GO:0043368) | 3.84390989 |
| 13 | leukocyte aggregation (GO:0070486) | 3.76328604 |
| 14 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.74046617 |
| 15 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.71245625 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.69945081 |
| 17 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.65464362 |
| 18 | T cell selection (GO:0045058) | 3.64345251 |
| 19 | cell migration in hindbrain (GO:0021535) | 3.63462310 |
| 20 | positive thymic T cell selection (GO:0045059) | 3.62411877 |
| 21 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.62019386 |
| 22 | activated T cell proliferation (GO:0050798) | 3.57997629 |
| 23 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.54093018 |
| 24 | dendrite morphogenesis (GO:0048813) | 3.53774276 |
| 25 | clathrin coat assembly (GO:0048268) | 3.53410366 |
| 26 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.53221888 |
| 27 | thymic T cell selection (GO:0045061) | 3.46674910 |
| 28 | protein localization to synapse (GO:0035418) | 3.43387325 |
| 29 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.42197582 |
| 30 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.40558435 |
| 31 | histone H3-K4 trimethylation (GO:0080182) | 3.38207815 |
| 32 | tolerance induction (GO:0002507) | 3.34175326 |
| 33 | vocalization behavior (GO:0071625) | 3.33875851 |
| 34 | dendritic spine morphogenesis (GO:0060997) | 3.33015216 |
| 35 | regulation of ARF protein signal transduction (GO:0032012) | 3.30549928 |
| 36 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.27616218 |
| 37 | mitochondrion transport along microtubule (GO:0047497) | 3.27616218 |
| 38 | regulation of gamma-delta T cell activation (GO:0046643) | 3.26825147 |
| 39 | exploration behavior (GO:0035640) | 3.25815659 |
| 40 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.24670494 |
| 41 | regulation of ARF GTPase activity (GO:0032312) | 3.24070243 |
| 42 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.21937748 |
| 43 | positive regulation of synapse maturation (GO:0090129) | 3.16938339 |
| 44 | neuron cell-cell adhesion (GO:0007158) | 3.16876539 |
| 45 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.16757674 |
| 46 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.16489711 |
| 47 | axonal fasciculation (GO:0007413) | 3.13306284 |
| 48 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.12695237 |
| 49 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.06594008 |
| 50 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.05197627 |
| 51 | synaptic vesicle exocytosis (GO:0016079) | 3.02377737 |
| 52 | neuron recognition (GO:0008038) | 2.99542841 |
| 53 | response to interleukin-15 (GO:0070672) | 2.98769490 |
| 54 | response to pheromone (GO:0019236) | 2.96746301 |
| 55 | T cell receptor signaling pathway (GO:0050852) | 2.95816117 |
| 56 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.94174738 |
| 57 | response to muramyl dipeptide (GO:0032495) | 2.92141008 |
| 58 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.92018159 |
| 59 | presynaptic membrane assembly (GO:0097105) | 2.91318629 |
| 60 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.91130854 |
| 61 | sodium ion export (GO:0071436) | 2.90371058 |
| 62 | establishment of mitochondrion localization (GO:0051654) | 2.88476524 |
| 63 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.88369941 |
| 64 | modulation by symbiont of host immune response (GO:0052553) | 2.88369941 |
| 65 | positive regulation by symbiont of host defense response (GO:0052509) | 2.88369941 |
| 66 | modulation by symbiont of host defense response (GO:0052031) | 2.88369941 |
| 67 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.88369941 |
| 68 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.88369941 |
| 69 | cytoplasmic mRNA processing body assembly (GO:0033962) | 2.88025086 |
| 70 | presynaptic membrane organization (GO:0097090) | 2.87591023 |
| 71 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.83997672 |
| 72 | histone H3-K4 methylation (GO:0051568) | 2.77969119 |
| 73 | regulation of defense response to virus by virus (GO:0050690) | 2.77856396 |
| 74 | glutamate secretion (GO:0014047) | 2.77134514 |
| 75 | cellular extravasation (GO:0045123) | 2.76089686 |
| 76 | B cell receptor signaling pathway (GO:0050853) | 2.75595064 |
| 77 | response to nerve growth factor (GO:1990089) | 2.73362032 |
| 78 | cellular response to nerve growth factor stimulus (GO:1990090) | 2.73362032 |
| 79 | positive regulation of granulocyte differentiation (GO:0030854) | 2.71927594 |
| 80 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.71660247 |
| 81 | regulation of synapse structural plasticity (GO:0051823) | 2.71619161 |
| 82 | T cell costimulation (GO:0031295) | 2.71416416 |
| 83 | regulation of T cell tolerance induction (GO:0002664) | 2.70401981 |
| 84 | adaptation of signaling pathway (GO:0023058) | 2.68249213 |
| 85 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.67957033 |
| 86 | T cell migration (GO:0072678) | 2.67932595 |
| 87 | positive regulation of Rap GTPase activity (GO:0032854) | 2.67527574 |
| 88 | cellular response to interleukin-15 (GO:0071350) | 2.67500476 |
| 89 | positive regulation of filopodium assembly (GO:0051491) | 2.67194317 |
| 90 | lymphocyte costimulation (GO:0031294) | 2.66299654 |
| 91 | synaptic transmission, glutamatergic (GO:0035249) | 2.65800397 |
| 92 | nerve growth factor signaling pathway (GO:0038180) | 2.65581272 |
| 93 | establishment of nucleus localization (GO:0040023) | 2.64763995 |
| 94 | glutamate receptor signaling pathway (GO:0007215) | 2.64582457 |
| 95 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.64347314 |
| 96 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.64191854 |
| 97 | pre-miRNA processing (GO:0031054) | 2.63808963 |
| 98 | central nervous system neuron axonogenesis (GO:0021955) | 2.63460103 |
| 99 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.63222247 |
| 100 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 2.62487264 |
| 101 | histone H3-K36 demethylation (GO:0070544) | 2.60435519 |
| 102 | signal complex assembly (GO:0007172) | 2.59883452 |
| 103 | macrophage activation involved in immune response (GO:0002281) | 2.57944555 |
| 104 | T cell homeostasis (GO:0043029) | 2.57868265 |
| 105 | proline transport (GO:0015824) | 2.57803351 |
| 106 | negative regulation of T cell mediated immunity (GO:0002710) | 2.56032848 |
| 107 | detection of other organism (GO:0098543) | 2.54684168 |
| 108 | synaptic vesicle endocytosis (GO:0048488) | 2.52834753 |
| 109 | regulation of regulatory T cell differentiation (GO:0045589) | 2.52492383 |
| 110 | regulation of Rap GTPase activity (GO:0032317) | 2.52123357 |
| 111 | cerebellum development (GO:0021549) | 2.51488244 |
| 112 | detection of bacterium (GO:0016045) | 2.49787123 |
| 113 | auditory behavior (GO:0031223) | 2.48424346 |
| 114 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.47794976 |
| 115 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 2.47109206 |
| 116 | long-term memory (GO:0007616) | 2.46920066 |
| 117 | germinal center formation (GO:0002467) | 2.46864768 |
| 118 | regulation of B cell differentiation (GO:0045577) | 2.46194364 |
| 119 | postsynaptic membrane organization (GO:0001941) | 2.46163942 |
| 120 | dopamine receptor signaling pathway (GO:0007212) | 2.45981959 |
| 121 | peptidyl-threonine phosphorylation (GO:0018107) | 2.44089483 |
| 122 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.43723503 |
| 123 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.42326054 |
| 124 | interferon-gamma production (GO:0032609) | 2.40123915 |
| 125 | positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145) | 2.39992302 |
| 126 | axon extension (GO:0048675) | 2.39515294 |
| 127 | negative regulation of axonogenesis (GO:0050771) | 2.39292971 |
| 128 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.39099987 |
| 129 | nucleosome disassembly (GO:0006337) | 2.37529431 |
| 130 | protein-DNA complex disassembly (GO:0032986) | 2.37529431 |
| 131 | positive regulation of axon extension (GO:0045773) | 2.35982288 |
| 132 | activation of protein kinase A activity (GO:0034199) | 2.35841485 |
| 133 | organelle transport along microtubule (GO:0072384) | 2.34108051 |
| 134 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 2.33322685 |
| 135 | regulation of synaptic vesicle transport (GO:1902803) | 2.32886531 |
| 136 | negative regulation of histone methylation (GO:0031061) | 2.31959110 |
| 137 | activation of JUN kinase activity (GO:0007257) | 2.31788658 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.76529163 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.53651575 |
| 3 | MYC_22102868_ChIP-Seq_BL_Human | 3.47170183 |
| 4 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.21414831 |
| 5 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 3.11910989 |
| 6 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.73940491 |
| 7 | KDM2B_26808549_Chip-Seq_DND41_Human | 2.73168647 |
| 8 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.64875521 |
| 9 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.64609046 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.38349643 |
| 11 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 2.36710792 |
| 12 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.32142283 |
| 13 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.25741577 |
| 14 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.23914237 |
| 15 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 2.18349246 |
| 16 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.18233209 |
| 17 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.16948691 |
| 18 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.14144979 |
| 19 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.11060688 |
| 20 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.96524690 |
| 21 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.95103729 |
| 22 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.93090802 |
| 23 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.92929657 |
| 24 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.91632345 |
| 25 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.88883537 |
| 26 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.81237984 |
| 27 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.78205759 |
| 28 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.77348329 |
| 29 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.70964685 |
| 30 | * MAF_26560356_Chip-Seq_TH1_Human | 1.70865093 |
| 31 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.65666658 |
| 32 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.63851009 |
| 33 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.59927240 |
| 34 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.59394652 |
| 35 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.58861325 |
| 36 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.57821891 |
| 37 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.57638370 |
| 38 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.57537086 |
| 39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.56639059 |
| 40 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.55250089 |
| 41 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.52953094 |
| 42 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.52528613 |
| 43 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.50964213 |
| 44 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.50356196 |
| 45 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.46336946 |
| 46 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.45746779 |
| 47 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.45145206 |
| 48 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.44846851 |
| 49 | MYB_26560356_Chip-Seq_TH2_Human | 1.43955557 |
| 50 | SPI1_23127762_ChIP-Seq_K562_Human | 1.42014786 |
| 51 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.39497744 |
| 52 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.32490705 |
| 53 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.32255866 |
| 54 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.29524722 |
| 55 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.27522523 |
| 56 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.26353573 |
| 57 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.26230162 |
| 58 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.24934484 |
| 59 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.22492458 |
| 60 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.20315566 |
| 61 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.19786742 |
| 62 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.19240593 |
| 63 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.18638772 |
| 64 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18638772 |
| 65 | * MYB_26560356_Chip-Seq_TH1_Human | 1.17520263 |
| 66 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.16334886 |
| 67 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14716159 |
| 68 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.12068529 |
| 69 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.12068529 |
| 70 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.11945743 |
| 71 | * MAF_26560356_Chip-Seq_TH2_Human | 1.11869918 |
| 72 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.10625974 |
| 73 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.10240798 |
| 74 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.08524934 |
| 75 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.07011935 |
| 76 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.06563619 |
| 77 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.05720318 |
| 78 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.05525830 |
| 79 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.05431608 |
| 80 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.04825412 |
| 81 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.03304773 |
| 82 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.03172288 |
| 83 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.03139217 |
| 84 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.02426826 |
| 85 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.02056241 |
| 86 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.01556994 |
| 87 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.00828855 |
| 88 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.00576042 |
| 89 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00091267 |
| 90 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.99812884 |
| 91 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 0.99326047 |
| 92 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99016117 |
| 93 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.98970154 |
| 94 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.98669790 |
| 95 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.98594147 |
| 96 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98305301 |
| 97 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.97513570 |
| 98 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.97298541 |
| 99 | * AR_19668381_ChIP-Seq_PC3_Human | 0.95014602 |
| 100 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.94563950 |
| 101 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.93963353 |
| 102 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.93706832 |
| 103 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.93577564 |
| 104 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.92964093 |
| 105 | * CTCF_27219007_Chip-Seq_Bcells_Human | 0.92943252 |
| 106 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.92371926 |
| 107 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.91670142 |
| 108 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 0.90965566 |
| 109 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.90706428 |
| 110 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.90409023 |
| 111 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.90131631 |
| 112 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.89721003 |
| 113 | ELK4_26923725_Chip-Seq_MESODERM_Mouse | 0.87658662 |
| 114 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.87085461 |
| 115 | GATA1_19941826_ChIP-Seq_K562_Human | 0.86606514 |
| 116 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.86576723 |
| 117 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.86079196 |
| 118 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85564432 |
| 119 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.85173987 |
| 120 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.84351786 |
| 121 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.84249787 |
| 122 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.83900549 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.01184694 |
| 2 | MP0005423_abnormal_somatic_nervous | 4.06950946 |
| 3 | MP0000569_abnormal_digit_pigmentation | 3.51374612 |
| 4 | MP0003303_peritoneal_inflammation | 3.04790749 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 2.72603664 |
| 6 | MP0000778_abnormal_nervous_system | 2.69745266 |
| 7 | MP0002822_catalepsy | 2.66206862 |
| 8 | MP0003763_abnormal_thymus_physiology | 2.59971708 |
| 9 | MP0003436_decreased_susceptibility_to | 2.42462981 |
| 10 | MP0004270_analgesia | 2.41729316 |
| 11 | MP0003787_abnormal_imprinting | 2.33321806 |
| 12 | MP0002063_abnormal_learning/memory/cond | 2.30707098 |
| 13 | MP0003724_increased_susceptibility_to | 2.20052303 |
| 14 | MP0008961_abnormal_basal_metabolism | 1.98868365 |
| 15 | MP0004811_abnormal_neuron_physiology | 1.88347096 |
| 16 | MP0003880_abnormal_central_pattern | 1.82404394 |
| 17 | MP0005076_abnormal_cell_differentiation | 1.77653239 |
| 18 | MP0005671_abnormal_response_to | 1.76157939 |
| 19 | MP0000703_abnormal_thymus_morphology | 1.70782760 |
| 20 | MP0009745_abnormal_behavioral_response | 1.68833734 |
| 21 | MP0002398_abnormal_bone_marrow | 1.64729603 |
| 22 | MP0001800_abnormal_humoral_immune | 1.64482987 |
| 23 | MP0002572_abnormal_emotion/affect_behav | 1.63330223 |
| 24 | MP0002064_seizures | 1.62819213 |
| 25 | MP0003172_abnormal_lysosome_physiology | 1.61792509 |
| 26 | MP0008569_lethality_at_weaning | 1.58977755 |
| 27 | MP0002396_abnormal_hematopoietic_system | 1.58074093 |
| 28 | MP0002184_abnormal_innervation | 1.56844582 |
| 29 | MP0003122_maternal_imprinting | 1.53308995 |
| 30 | MP0002272_abnormal_nervous_system | 1.51947884 |
| 31 | MP0004885_abnormal_endolymph | 1.49166669 |
| 32 | MP0005025_abnormal_response_to | 1.48742745 |
| 33 | MP0009278_abnormal_bone_marrow | 1.48282935 |
| 34 | MP0003690_abnormal_glial_cell | 1.46606464 |
| 35 | MP0000955_abnormal_spinal_cord | 1.43755389 |
| 36 | MP0004742_abnormal_vestibular_system | 1.43744599 |
| 37 | MP0002419_abnormal_innate_immunity | 1.42722915 |
| 38 | MP0000685_abnormal_immune_system | 1.42444901 |
| 39 | MP0002420_abnormal_adaptive_immunity | 1.41917444 |
| 40 | MP0002735_abnormal_chemical_nociception | 1.41729225 |
| 41 | MP0001486_abnormal_startle_reflex | 1.41205870 |
| 42 | MP0001790_abnormal_immune_system | 1.40365954 |
| 43 | MP0005387_immune_system_phenotype | 1.40365954 |
| 44 | MP0001986_abnormal_taste_sensitivity | 1.40124713 |
| 45 | MP0001819_abnormal_immune_cell | 1.39859719 |
| 46 | MP0005174_abnormal_tail_pigmentation | 1.39167925 |
| 47 | MP0001968_abnormal_touch/_nociception | 1.38821717 |
| 48 | MP0002734_abnormal_mechanical_nocicepti | 1.37950836 |
| 49 | MP0009780_abnormal_chondrocyte_physiolo | 1.37784210 |
| 50 | MP0002733_abnormal_thermal_nociception | 1.36945552 |
| 51 | MP0004142_abnormal_muscle_tone | 1.35337451 |
| 52 | MP0002557_abnormal_social/conspecific_i | 1.34021402 |
| 53 | MP0002882_abnormal_neuron_morphology | 1.29246770 |
| 54 | MP0004510_myositis | 1.29187337 |
| 55 | MP0000716_abnormal_immune_system | 1.29048999 |
| 56 | MP0003300_gastrointestinal_ulcer | 1.27915219 |
| 57 | MP0002653_abnormal_ependyma_morphology | 1.27147983 |
| 58 | MP0005386_behavior/neurological_phenoty | 1.25974334 |
| 59 | MP0004924_abnormal_behavior | 1.25974334 |
| 60 | MP0001501_abnormal_sleep_pattern | 1.25697690 |
| 61 | MP0002452_abnormal_antigen_presenting | 1.25493251 |
| 62 | MP0000015_abnormal_ear_pigmentation | 1.25488262 |
| 63 | MP0002152_abnormal_brain_morphology | 1.25244506 |
| 64 | MP0002166_altered_tumor_susceptibility | 1.24348686 |
| 65 | MP0000465_gastrointestinal_hemorrhage | 1.23169657 |
| 66 | MP0001348_abnormal_lacrimal_gland | 1.21234160 |
| 67 | MP0002723_abnormal_immune_serum | 1.20804493 |
| 68 | MP0005551_abnormal_eye_electrophysiolog | 1.20340031 |
| 69 | MP0003329_amyloid_beta_deposits | 1.19665939 |
| 70 | MP0001970_abnormal_pain_threshold | 1.19231984 |
| 71 | MP0001873_stomach_inflammation | 1.17839582 |
| 72 | MP0003121_genomic_imprinting | 1.16234540 |
| 73 | MP0001835_abnormal_antigen_presentation | 1.15916912 |
| 74 | MP0003866_abnormal_defecation | 1.15086241 |
| 75 | MP0004130_abnormal_muscle_cell | 1.14694417 |
| 76 | MP0003183_abnormal_peptide_metabolism | 1.14144262 |
| 77 | MP0004381_abnormal_hair_follicle | 1.13352943 |
| 78 | MP0002722_abnormal_immune_system | 1.11344516 |
| 79 | MP0003861_abnormal_nervous_system | 1.10419282 |
| 80 | MP0004858_abnormal_nervous_system | 1.09991357 |
| 81 | MP0006072_abnormal_retinal_apoptosis | 1.09957623 |
| 82 | MP0005394_taste/olfaction_phenotype | 1.08680360 |
| 83 | MP0005499_abnormal_olfactory_system | 1.08680360 |
| 84 | MP0009046_muscle_twitch | 1.08395453 |
| 85 | MP0005310_abnormal_salivary_gland | 1.08375372 |
| 86 | MP0004808_abnormal_hematopoietic_stem | 1.07868637 |
| 87 | MP0006276_abnormal_autonomic_nervous | 1.05080245 |
| 88 | MP0002067_abnormal_sensory_capabilities | 1.04707685 |
| 89 | MP0005645_abnormal_hypothalamus_physiol | 1.01815249 |
| 90 | MP0005000_abnormal_immune_tolerance | 1.01476187 |
| 91 | MP0000689_abnormal_spleen_morphology | 0.99778135 |
| 92 | MP0002909_abnormal_adrenal_gland | 0.99172617 |
| 93 | MP0010352_gastrointestinal_tract_polyps | 0.97743656 |
| 94 | MP0009785_altered_susceptibility_to | 0.96084086 |
| 95 | MP0001440_abnormal_grooming_behavior | 0.95839048 |
| 96 | MP0003879_abnormal_hair_cell | 0.95310257 |
| 97 | MP0001188_hyperpigmentation | 0.95190499 |
| 98 | MP0002429_abnormal_blood_cell | 0.94107436 |
| 99 | MP0002405_respiratory_system_inflammati | 0.92842379 |
| 100 | MP0009333_abnormal_splenocyte_physiolog | 0.89317415 |
| 101 | MP0000537_abnormal_urethra_morphology | 0.88749111 |
| 102 | MP0002066_abnormal_motor_capabilities/c | 0.88583872 |
| 103 | MP0001502_abnormal_circadian_rhythm | 0.86249701 |
| 104 | MP0005464_abnormal_platelet_physiology | 0.86222903 |
| 105 | MP0008877_abnormal_DNA_methylation | 0.84046702 |
| 106 | MP0000920_abnormal_myelination | 0.84023543 |
| 107 | MP0000631_abnormal_neuroendocrine_gland | 0.83730959 |
| 108 | MP0003631_nervous_system_phenotype | 0.82940847 |
| 109 | MP0005253_abnormal_eye_physiology | 0.82689261 |
| 110 | MP0003633_abnormal_nervous_system | 0.82596160 |
| 111 | MP0008874_decreased_physiological_sensi | 0.82039535 |
| 112 | MP0002736_abnormal_nociception_after | 0.82005357 |
| 113 | MP0002006_tumorigenesis | 0.80223482 |
| 114 | MP0001984_abnormal_olfaction | 0.78828792 |
| 115 | MP0000604_amyloidosis | 0.76421152 |
| 116 | MP0005187_abnormal_penis_morphology | 0.74156515 |
| 117 | MP0006082_CNS_inflammation | 0.74146102 |
| 118 | MP0001533_abnormal_skeleton_physiology | 0.73815571 |
| 119 | MP0005535_abnormal_body_temperature | 0.72958753 |
| 120 | MP0008770_decreased_survivor_rate | 0.72291164 |
| 121 | MP0002148_abnormal_hypersensitivity_rea | 0.72019680 |
| 122 | MP0004947_skin_inflammation | 0.71458635 |
| 123 | MP0002229_neurodegeneration | 0.69629628 |
| 124 | MP0010155_abnormal_intestine_physiology | 0.69254732 |
| 125 | MP0005195_abnormal_posterior_eye | 0.68861023 |
| 126 | MP0003634_abnormal_glial_cell | 0.67905131 |
| 127 | MP0002095_abnormal_skin_pigmentation | 0.66718083 |
| 128 | MP0003119_abnormal_digestive_system | 0.66590704 |
| 129 | MP0008789_abnormal_olfactory_epithelium | 0.66283075 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 4.23797368 |
| 2 | Stomatitis (HP:0010280) | 3.48132465 |
| 3 | Hyperacusis (HP:0010780) | 3.45829877 |
| 4 | Focal motor seizures (HP:0011153) | 3.39072849 |
| 5 | Amyotrophic lateral sclerosis (HP:0007354) | 3.35941418 |
| 6 | Recurrent bacterial skin infections (HP:0005406) | 3.31782573 |
| 7 | Myositis (HP:0100614) | 3.30793361 |
| 8 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.23547060 |
| 9 | Retrobulbar optic neuritis (HP:0100654) | 3.20405025 |
| 10 | Optic neuritis (HP:0100653) | 3.20405025 |
| 11 | Mutism (HP:0002300) | 3.18197447 |
| 12 | Abnormality of the fingertips (HP:0001211) | 3.18100004 |
| 13 | Recurrent abscess formation (HP:0002722) | 3.09701770 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 3.09215054 |
| 15 | T lymphocytopenia (HP:0005403) | 3.00532696 |
| 16 | Orchitis (HP:0100796) | 2.92352425 |
| 17 | Macroorchidism (HP:0000053) | 2.91212977 |
| 18 | Papilledema (HP:0001085) | 2.80612289 |
| 19 | Abnormality of T cell number (HP:0011839) | 2.78585599 |
| 20 | Heterotopia (HP:0002282) | 2.77330207 |
| 21 | Inappropriate behavior (HP:0000719) | 2.74565300 |
| 22 | Limb dystonia (HP:0002451) | 2.69454964 |
| 23 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.68750890 |
| 24 | Febrile seizures (HP:0002373) | 2.67482036 |
| 25 | Peripheral hypomyelination (HP:0007182) | 2.66852172 |
| 26 | Meningitis (HP:0001287) | 2.65131684 |
| 27 | Elfin facies (HP:0004428) | 2.62656357 |
| 28 | Neurofibrillary tangles (HP:0002185) | 2.59916714 |
| 29 | Panhypogammaglobulinemia (HP:0003139) | 2.59617000 |
| 30 | Mediastinal lymphadenopathy (HP:0100721) | 2.56382345 |
| 31 | Insomnia (HP:0100785) | 2.52140178 |
| 32 | Obstructive lung disease (HP:0006536) | 2.50452042 |
| 33 | Chronic obstructive pulmonary disease (HP:0006510) | 2.50452042 |
| 34 | Encephalitis (HP:0002383) | 2.48989658 |
| 35 | Gastrointestinal infarctions (HP:0005244) | 2.48212432 |
| 36 | Aqueductal stenosis (HP:0002410) | 2.47192400 |
| 37 | Hypochromic microcytic anemia (HP:0004840) | 2.46350124 |
| 38 | Postural instability (HP:0002172) | 2.43340417 |
| 39 | Genetic anticipation (HP:0003743) | 2.42992253 |
| 40 | Polyphagia (HP:0002591) | 2.42511959 |
| 41 | Disinhibition (HP:0000734) | 2.42495585 |
| 42 | Urinary urgency (HP:0000012) | 2.41028002 |
| 43 | Visual hallucinations (HP:0002367) | 2.40793167 |
| 44 | Thyroiditis (HP:0100646) | 2.38383205 |
| 45 | Abnormality of the corticospinal tract (HP:0002492) | 2.37986611 |
| 46 | Short 4th metacarpal (HP:0010044) | 2.37846053 |
| 47 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.37846053 |
| 48 | Drooling (HP:0002307) | 2.36899315 |
| 49 | Excessive salivation (HP:0003781) | 2.36899315 |
| 50 | Apathy (HP:0000741) | 2.36368335 |
| 51 | Spontaneous hematomas (HP:0007420) | 2.33588066 |
| 52 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.32993268 |
| 53 | Abnormality of macrophages (HP:0004311) | 2.32922839 |
| 54 | Deep palmar crease (HP:0006191) | 2.32692552 |
| 55 | Recurrent viral infections (HP:0004429) | 2.31423760 |
| 56 | Diplopia (HP:0000651) | 2.30863740 |
| 57 | Abnormality of binocular vision (HP:0011514) | 2.30863740 |
| 58 | Increased IgE level (HP:0003212) | 2.29743274 |
| 59 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.29455315 |
| 60 | Recurrent cutaneous fungal infections (HP:0011370) | 2.29455315 |
| 61 | Epileptic encephalopathy (HP:0200134) | 2.26867405 |
| 62 | Agammaglobulinemia (HP:0004432) | 2.26634090 |
| 63 | Obstructive sleep apnea (HP:0002870) | 2.25123901 |
| 64 | Pointed chin (HP:0000307) | 2.24261355 |
| 65 | Overriding aorta (HP:0002623) | 2.23622765 |
| 66 | Myokymia (HP:0002411) | 2.22740883 |
| 67 | Sacral dimple (HP:0000960) | 2.22654628 |
| 68 | Ankle clonus (HP:0011448) | 2.22338855 |
| 69 | Verrucae (HP:0200043) | 2.22123053 |
| 70 | Papilloma (HP:0012740) | 2.22123053 |
| 71 | Focal seizures (HP:0007359) | 2.22046643 |
| 72 | Hypochromic anemia (HP:0001931) | 2.19416819 |
| 73 | Subacute progressive viral hepatitis (HP:0006572) | 2.18947896 |
| 74 | Vasculitis (HP:0002633) | 2.17683966 |
| 75 | Keratoconjunctivitis sicca (HP:0001097) | 2.17466033 |
| 76 | Gingivitis (HP:0000230) | 2.17160673 |
| 77 | Diminished motivation (HP:0000745) | 2.14755033 |
| 78 | Recurrent skin infections (HP:0001581) | 2.13181503 |
| 79 | Severe combined immunodeficiency (HP:0004430) | 2.13177635 |
| 80 | Abnormality of the astrocytes (HP:0100707) | 2.12315032 |
| 81 | Astrocytoma (HP:0009592) | 2.12315032 |
| 82 | Cortical dysplasia (HP:0002539) | 2.11616828 |
| 83 | Neuronal loss in central nervous system (HP:0002529) | 2.11344288 |
| 84 | Hyperventilation (HP:0002883) | 2.10209841 |
| 85 | Broad-based gait (HP:0002136) | 2.09934053 |
| 86 | Recurrent fungal infections (HP:0002841) | 2.07229220 |
| 87 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.07059896 |
| 88 | Renovascular hypertension (HP:0100817) | 2.06002893 |
| 89 | Pustule (HP:0200039) | 2.05463146 |
| 90 | Agitation (HP:0000713) | 2.05442918 |
| 91 | Neoplasm of the adrenal cortex (HP:0100641) | 2.04931686 |
| 92 | Congenital stationary night blindness (HP:0007642) | 2.04393512 |
| 93 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.04311897 |
| 94 | Lymphopenia (HP:0001888) | 2.04103029 |
| 95 | Slow saccadic eye movements (HP:0000514) | 2.03578920 |
| 96 | Action tremor (HP:0002345) | 2.03260376 |
| 97 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.03202317 |
| 98 | Leukocytosis (HP:0001974) | 1.99417511 |
| 99 | Abnormality of the lower motor neuron (HP:0002366) | 1.99016851 |
| 100 | Keratoconjunctivitis (HP:0001096) | 1.98118934 |
| 101 | Prolonged bleeding time (HP:0003010) | 1.97915842 |
| 102 | Tented upper lip vermilion (HP:0010804) | 1.96975577 |
| 103 | Akinesia (HP:0002304) | 1.96775517 |
| 104 | Obsessive-compulsive behavior (HP:0000722) | 1.95038000 |
| 105 | Stereotypic behavior (HP:0000733) | 1.94116103 |
| 106 | Open mouth (HP:0000194) | 1.93971836 |
| 107 | Pachygyria (HP:0001302) | 1.93769433 |
| 108 | Trigonocephaly (HP:0000243) | 1.92836341 |
| 109 | Cellulitis (HP:0100658) | 1.91930957 |
| 110 | Hemiplegia (HP:0002301) | 1.91174119 |
| 111 | B lymphocytopenia (HP:0010976) | 1.89429512 |
| 112 | Abnormality of B cell number (HP:0010975) | 1.89429512 |
| 113 | Atonic seizures (HP:0010819) | 1.88642878 |
| 114 | Spastic gait (HP:0002064) | 1.87896540 |
| 115 | Basal cell carcinoma (HP:0002671) | 1.87773404 |
| 116 | Abnormal social behavior (HP:0012433) | 1.87020696 |
| 117 | Impaired social interactions (HP:0000735) | 1.87020696 |
| 118 | Recurrent bronchitis (HP:0002837) | 1.86482517 |
| 119 | Combined immunodeficiency (HP:0005387) | 1.85648485 |
| 120 | Hepatoblastoma (HP:0002884) | 1.83595874 |
| 121 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.83482488 |
| 122 | Protruding tongue (HP:0010808) | 1.82439815 |
| 123 | Volvulus (HP:0002580) | 1.81730231 |
| 124 | Narrow palate (HP:0000189) | 1.80451624 |
| 125 | Sleep apnea (HP:0010535) | 1.80177189 |
| 126 | Fetal akinesia sequence (HP:0001989) | 1.79491391 |
| 127 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.78618400 |
| 128 | Annular pancreas (HP:0001734) | 1.78280319 |
| 129 | Abnormal hair whorl (HP:0010721) | 1.77604235 |
| 130 | Truncal ataxia (HP:0002078) | 1.77092906 |
| 131 | Memory impairment (HP:0002354) | 1.75375108 |
| 132 | Renal duplication (HP:0000075) | 1.75156702 |
| 133 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.73604697 |
| 134 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.73003499 |
| 135 | Gastrointestinal inflammation (HP:0004386) | 1.72364867 |
| 136 | Hypoplasia of the brainstem (HP:0002365) | 1.72222750 |
| 137 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.72222750 |
| 138 | Poor eye contact (HP:0000817) | 1.71943312 |
| 139 | Increased nuchal translucency (HP:0010880) | 1.71770235 |
| 140 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.71394036 |
| 141 | Abnormality of T cells (HP:0002843) | 1.71186610 |
| 142 | Vertebral arch anomaly (HP:0008438) | 1.70848497 |
| 143 | Viral hepatitis (HP:0006562) | 1.67753893 |
| 144 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.67701862 |
| 145 | Abnormal eating behavior (HP:0100738) | 1.67457814 |
| 146 | Progressive cerebellar ataxia (HP:0002073) | 1.67121367 |
| 147 | Megalencephaly (HP:0001355) | 1.66153710 |
| 148 | Cerebral inclusion bodies (HP:0100314) | 1.65592413 |
| 149 | Colitis (HP:0002583) | 1.64959188 |
| 150 | Inflammation of the large intestine (HP:0002037) | 1.64422101 |
| 151 | Flat cornea (HP:0007720) | 1.64094247 |
| 152 | Abnormality of the intervertebral disk (HP:0005108) | 1.63977921 |
| 153 | Progressive inability to walk (HP:0002505) | 1.63797969 |
| 154 | Termporal pattern (HP:0011008) | 1.63439534 |
| 155 | Insidious onset (HP:0003587) | 1.63439534 |
| 156 | Cutis marmorata (HP:0000965) | 1.63432155 |
| 157 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.61090707 |
| 158 | Chest pain (HP:0100749) | 1.61083051 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 6.09759419 |
| 2 | SIK2 | 3.58636436 |
| 3 | MAP3K10 | 3.19381953 |
| 4 | CASK | 2.99135722 |
| 5 | MAP3K9 | 2.86656483 |
| 6 | MAP4K1 | 2.79198575 |
| 7 | NTRK2 | 2.21555356 |
| 8 | EEF2K | 1.96100099 |
| 9 | TYRO3 | 1.75201117 |
| 10 | CAMK1G | 1.73696998 |
| 11 | GRK6 | 1.61474479 |
| 12 | ICK | 1.58994867 |
| 13 | TNK2 | 1.58435355 |
| 14 | MARK2 | 1.56184770 |
| 15 | TXK | 1.51888098 |
| 16 | MAP3K4 | 1.51107376 |
| 17 | PAK6 | 1.48383912 |
| 18 | TAOK1 | 1.46554385 |
| 19 | PKN2 | 1.39700723 |
| 20 | MINK1 | 1.39256178 |
| 21 | MAPK13 | 1.36836299 |
| 22 | BLK | 1.35273128 |
| 23 | KSR1 | 1.33937704 |
| 24 | TRIB3 | 1.33469068 |
| 25 | DYRK2 | 1.32652240 |
| 26 | ITK | 1.32222378 |
| 27 | TAOK3 | 1.30651365 |
| 28 | CDK12 | 1.29060689 |
| 29 | ALK | 1.24176682 |
| 30 | BTK | 1.23565725 |
| 31 | PRKCH | 1.22001324 |
| 32 | EPHA4 | 1.19294011 |
| 33 | PHKG1 | 1.18951563 |
| 34 | PHKG2 | 1.18951563 |
| 35 | FES | 1.14134049 |
| 36 | FGFR3 | 1.11386984 |
| 37 | SGK2 | 1.09840151 |
| 38 | SGK494 | 1.08991772 |
| 39 | SGK223 | 1.08991772 |
| 40 | CSNK1G2 | 1.08776285 |
| 41 | FGFR2 | 1.08526355 |
| 42 | CAMKK1 | 1.06634353 |
| 43 | DAPK2 | 1.06265797 |
| 44 | SYK | 1.06183452 |
| 45 | ERBB3 | 1.05667520 |
| 46 | STK11 | 1.04439726 |
| 47 | IRAK4 | 1.02098568 |
| 48 | EPHB1 | 0.99245788 |
| 49 | HCK | 0.98762698 |
| 50 | CDK5 | 0.96165135 |
| 51 | MAPK12 | 0.94409689 |
| 52 | CSNK1A1L | 0.94153825 |
| 53 | MAP3K7 | 0.93324639 |
| 54 | TNIK | 0.93242778 |
| 55 | MAP3K11 | 0.92478968 |
| 56 | NTRK3 | 0.92140764 |
| 57 | MAP3K13 | 0.91792206 |
| 58 | CAMK1D | 0.90130318 |
| 59 | MAP2K4 | 0.90057768 |
| 60 | PKN1 | 0.90000553 |
| 61 | CDK19 | 0.89523437 |
| 62 | PNCK | 0.87301729 |
| 63 | BRD4 | 0.85316186 |
| 64 | FGFR4 | 0.84789386 |
| 65 | UHMK1 | 0.84383341 |
| 66 | CAMKK2 | 0.82324680 |
| 67 | RET | 0.81643331 |
| 68 | RPS6KA2 | 0.80854246 |
| 69 | MAP2K3 | 0.80848598 |
| 70 | ZAP70 | 0.80406247 |
| 71 | IKBKE | 0.79367600 |
| 72 | LYN | 0.79190405 |
| 73 | JAK3 | 0.77153834 |
| 74 | JAK1 | 0.74738781 |
| 75 | DYRK1A | 0.74201552 |
| 76 | SGK3 | 0.73799141 |
| 77 | LCK | 0.73621157 |
| 78 | CAMK4 | 0.73377312 |
| 79 | RIPK1 | 0.72184736 |
| 80 | CSNK1G3 | 0.72077749 |
| 81 | CLK1 | 0.71899758 |
| 82 | YES1 | 0.71546842 |
| 83 | PDGFRB | 0.69904321 |
| 84 | FYN | 0.68978635 |
| 85 | STK10 | 0.67480289 |
| 86 | MAP2K7 | 0.66554933 |
| 87 | PRKCZ | 0.65902907 |
| 88 | KSR2 | 0.65350227 |
| 89 | PRKD3 | 0.65084753 |
| 90 | CSK | 0.64799496 |
| 91 | EPHA3 | 0.64476530 |
| 92 | DAPK1 | 0.63924419 |
| 93 | CSF1R | 0.63919063 |
| 94 | MAP3K1 | 0.61322538 |
| 95 | MAP3K14 | 0.61285607 |
| 96 | TYK2 | 0.61171220 |
| 97 | PASK | 0.61042986 |
| 98 | PRPF4B | 0.60240876 |
| 99 | PRKD2 | 0.59557190 |
| 100 | FGR | 0.56044599 |
| 101 | NLK | 0.55915902 |
| 102 | HIPK2 | 0.55742761 |
| 103 | MAPK9 | 0.53827274 |
| 104 | CDC42BPA | 0.52728288 |
| 105 | RIPK4 | 0.50537743 |
| 106 | SIK3 | 0.49797984 |
| 107 | CSNK1G1 | 0.49428039 |
| 108 | PTK6 | 0.49404192 |
| 109 | PDK1 | 0.48024643 |
| 110 | MAPK8 | 0.47718770 |
| 111 | DMPK | 0.46958947 |
| 112 | PRKCG | 0.45331762 |
| 113 | CSNK1D | 0.45298607 |
| 114 | MTOR | 0.45015221 |
| 115 | SGK1 | 0.44368284 |
| 116 | MAP3K6 | 0.43867992 |
| 117 | JAK2 | 0.43862891 |
| 118 | CAMK1 | 0.43690232 |
| 119 | STK38 | 0.43478698 |
| 120 | PDGFRA | 0.42753464 |
| 121 | MAPK4 | 0.41889486 |
| 122 | CDK15 | 0.41840338 |
| 123 | MARK3 | 0.41674503 |
| 124 | ERBB2 | 0.41122882 |
| 125 | MAPK7 | 0.40769444 |
| 126 | PRKCQ | 0.40521787 |
| 127 | DYRK1B | 0.40373202 |
| 128 | CDK18 | 0.40281641 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.16186436 |
| 2 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.03143417 |
| 3 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.84238926 |
| 4 | Colorectal cancer_Homo sapiens_hsa05210 | 1.71446302 |
| 5 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.63920554 |
| 6 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.62531491 |
| 7 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.61146596 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 1.59182943 |
| 9 | Endometrial cancer_Homo sapiens_hsa05213 | 1.56361545 |
| 10 | Axon guidance_Homo sapiens_hsa04360 | 1.55685776 |
| 11 | Long-term potentiation_Homo sapiens_hsa04720 | 1.44930724 |
| 12 | Phototransduction_Homo sapiens_hsa04744 | 1.44474010 |
| 13 | Morphine addiction_Homo sapiens_hsa05032 | 1.40494881 |
| 14 | Circadian entrainment_Homo sapiens_hsa04713 | 1.36743594 |
| 15 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.35352740 |
| 16 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.33520446 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.30666882 |
| 18 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.30123147 |
| 19 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.30023202 |
| 20 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.29841657 |
| 21 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.29396744 |
| 22 | Viral myocarditis_Homo sapiens_hsa05416 | 1.26545849 |
| 23 | Glioma_Homo sapiens_hsa05214 | 1.26468286 |
| 24 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.25500969 |
| 25 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.25206811 |
| 26 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.23740670 |
| 27 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.23391659 |
| 28 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.23185904 |
| 29 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.22623846 |
| 30 | Nicotine addiction_Homo sapiens_hsa05033 | 1.22140618 |
| 31 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.22019884 |
| 32 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.20618213 |
| 33 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.20385528 |
| 34 | GABAergic synapse_Homo sapiens_hsa04727 | 1.20125758 |
| 35 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.18495146 |
| 36 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.18407160 |
| 37 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.18097268 |
| 38 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.13509553 |
| 39 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.13370457 |
| 40 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.12747481 |
| 41 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.08460553 |
| 42 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.07386655 |
| 43 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.06827098 |
| 44 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.06556378 |
| 45 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.05814311 |
| 46 | Salivary secretion_Homo sapiens_hsa04970 | 1.05480242 |
| 47 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.05151948 |
| 48 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.04242677 |
| 49 | Tuberculosis_Homo sapiens_hsa05152 | 1.03985289 |
| 50 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.03771754 |
| 51 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.02783716 |
| 52 | Renin secretion_Homo sapiens_hsa04924 | 1.01606587 |
| 53 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.01317030 |
| 54 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.00667766 |
| 55 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.00302969 |
| 56 | Gap junction_Homo sapiens_hsa04540 | 0.99991127 |
| 57 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.99839532 |
| 58 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.98072378 |
| 59 | Allograft rejection_Homo sapiens_hsa05330 | 0.96286208 |
| 60 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.95767258 |
| 61 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.95195435 |
| 62 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.94646244 |
| 63 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.94253105 |
| 64 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.93986778 |
| 65 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.91456021 |
| 66 | Platelet activation_Homo sapiens_hsa04611 | 0.91256215 |
| 67 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.87025380 |
| 68 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.84493208 |
| 69 | Long-term depression_Homo sapiens_hsa04730 | 0.84473081 |
| 70 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.84061681 |
| 71 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.84019221 |
| 72 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.81519355 |
| 73 | Endocytosis_Homo sapiens_hsa04144 | 0.81495305 |
| 74 | Measles_Homo sapiens_hsa05162 | 0.80564325 |
| 75 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.79956913 |
| 76 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.79836236 |
| 77 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.79417234 |
| 78 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.79396416 |
| 79 | Insulin secretion_Homo sapiens_hsa04911 | 0.79248067 |
| 80 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.77663919 |
| 81 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.77628012 |
| 82 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.77608738 |
| 83 | Hepatitis B_Homo sapiens_hsa05161 | 0.77516514 |
| 84 | Cocaine addiction_Homo sapiens_hsa05030 | 0.77454768 |
| 85 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76920163 |
| 86 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.76773581 |
| 87 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.75987216 |
| 88 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.74327081 |
| 89 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.73122717 |
| 90 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.72574134 |
| 91 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.70896193 |
| 92 | Taste transduction_Homo sapiens_hsa04742 | 0.70595093 |
| 93 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.69882661 |
| 94 | Leishmaniasis_Homo sapiens_hsa05140 | 0.69342888 |
| 95 | Influenza A_Homo sapiens_hsa05164 | 0.69246434 |
| 96 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.68937324 |
| 97 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.68343285 |
| 98 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.67742287 |
| 99 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.67108303 |
| 100 | Melanogenesis_Homo sapiens_hsa04916 | 0.66967990 |
| 101 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.66878096 |
| 102 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.65852991 |
| 103 | HTLV-I infection_Homo sapiens_hsa05166 | 0.65729904 |
| 104 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.65605730 |
| 105 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.65321092 |
| 106 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.64420806 |
| 107 | Lysine degradation_Homo sapiens_hsa00310 | 0.63219313 |
| 108 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.63058650 |
| 109 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.62320873 |
| 110 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.62255590 |
| 111 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.61719600 |
| 112 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.60639885 |
| 113 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.60484114 |
| 114 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.58907553 |
| 115 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.57943155 |

