KIF24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)6.96140784
2mitotic sister chromatid segregation (GO:0000070)6.22102646
3sister chromatid segregation (GO:0000819)6.13582203
4DNA unwinding involved in DNA replication (GO:0006268)5.68875899
5meiotic chromosome segregation (GO:0045132)5.58299701
6nuclear pore complex assembly (GO:0051292)5.56105159
7regulation of DNA endoreduplication (GO:0032875)5.45409185
8DNA strand elongation involved in DNA replication (GO:0006271)5.42631639
9DNA replication checkpoint (GO:0000076)5.39725176
10DNA strand elongation (GO:0022616)5.27286646
11telomere maintenance via semi-conservative replication (GO:0032201)5.25379483
12protein localization to chromosome, centromeric region (GO:0071459)5.21800442
13chromosome condensation (GO:0030261)5.20798687
14protein localization to kinetochore (GO:0034501)5.11381266
15mitotic sister chromatid cohesion (GO:0007064)4.91781022
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.75323413
17regulation of centriole replication (GO:0046599)4.73071419
18nuclear pore organization (GO:0006999)4.68274861
19DNA packaging (GO:0006323)4.62665601
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.59089999
21mitotic recombination (GO:0006312)4.58848995
22telomere maintenance via recombination (GO:0000722)4.52935719
23mitotic metaphase plate congression (GO:0007080)4.52471289
24DNA replication initiation (GO:0006270)4.28230741
25DNA topological change (GO:0006265)4.26391677
26regulation of centrosome cycle (GO:0046605)4.24716364
27metaphase plate congression (GO:0051310)4.20847252
28pore complex assembly (GO:0046931)4.13327359
29mitotic nuclear envelope disassembly (GO:0007077)4.01675302
30chromosome segregation (GO:0007059)3.97057565
31protein localization to chromosome (GO:0034502)3.84640594
32regulation of centrosome duplication (GO:0010824)3.82921035
33positive regulation of chromosome segregation (GO:0051984)3.80861794
34positive regulation of DNA-dependent DNA replication (GO:2000105)3.77537639
35DNA conformation change (GO:0071103)3.77285040
36spindle assembly involved in mitosis (GO:0090307)3.76784406
37keratinocyte development (GO:0003334)3.75499258
38histone exchange (GO:0043486)3.75234158
39membrane disassembly (GO:0030397)3.74583937
40nuclear envelope disassembly (GO:0051081)3.74583937
41preassembly of GPI anchor in ER membrane (GO:0016254)3.73744799
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.73571006
43DNA replication-independent nucleosome assembly (GO:0006336)3.71337783
44DNA replication-independent nucleosome organization (GO:0034724)3.71337783
45regulation of chromosome segregation (GO:0051983)3.69332453
46DNA double-strand break processing (GO:0000729)3.67165553
47establishment of chromosome localization (GO:0051303)3.66739531
48regulation of mitotic spindle organization (GO:0060236)3.63024704
49DNA duplex unwinding (GO:0032508)3.57724567
50axonemal dynein complex assembly (GO:0070286)3.56010702
51regulation of spindle organization (GO:0090224)3.54018238
52ribosomal small subunit biogenesis (GO:0042274)3.50212795
53DNA geometric change (GO:0032392)3.46761993
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44790699
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44790699
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.44790699
57regulation of sister chromatid cohesion (GO:0007063)3.43756010
58piRNA metabolic process (GO:0034587)3.43296798
59telomere maintenance via telomere lengthening (GO:0010833)3.42897154
60* microtubule polymerization or depolymerization (GO:0031109)3.42687780
61motile cilium assembly (GO:0044458)3.34987076
62translesion synthesis (GO:0019985)3.34582947
63spindle checkpoint (GO:0031577)3.34545001
64sister chromatid cohesion (GO:0007062)3.34269116
65chromatin assembly or disassembly (GO:0006333)3.32249188
66chromosome organization (GO:0051276)3.29504025
67DNA replication-dependent nucleosome assembly (GO:0006335)3.28585611
68DNA replication-dependent nucleosome organization (GO:0034723)3.28585611
69negative regulation of chromosome segregation (GO:0051985)3.28585205
70ATP-dependent chromatin remodeling (GO:0043044)3.26426324
71microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.26207546
72cilium or flagellum-dependent cell motility (GO:0001539)3.25098058
73long-chain fatty acid biosynthetic process (GO:0042759)3.24490628
74chromosome organization involved in meiosis (GO:0070192)3.22114546
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.21839233
76regulation of mitotic metaphase/anaphase transition (GO:0030071)3.21839233
77axon ensheathment in central nervous system (GO:0032291)3.21690551
78central nervous system myelination (GO:0022010)3.21690551
79mitotic cell cycle (GO:0000278)3.20195881
80sympathetic nervous system development (GO:0048485)3.19136967
81double-strand break repair via nonhomologous end joining (GO:0006303)3.18977597
82non-recombinational repair (GO:0000726)3.18977597
83base-excision repair (GO:0006284)3.18620309
84DNA methylation involved in gamete generation (GO:0043046)3.18591845
85DNA strand renaturation (GO:0000733)3.17938101
86regulation of mitotic sister chromatid separation (GO:0010965)3.16980361
87regulation of mitotic sister chromatid segregation (GO:0033047)3.16980361
88regulation of sister chromatid segregation (GO:0033045)3.16980361
89regulation of DNA-dependent DNA replication (GO:0090329)3.16032471
90GPI anchor biosynthetic process (GO:0006506)3.15480589
91establishment of integrated proviral latency (GO:0075713)3.13794133
92regulation of double-strand break repair via homologous recombination (GO:0010569)3.12726215
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12444059
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12444059
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12444059
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.12444059
97negative regulation of sister chromatid segregation (GO:0033046)3.12444059
98developmental pigmentation (GO:0048066)3.07318179
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06560686
100negative regulation of translation, ncRNA-mediated (GO:0040033)3.06560686
101regulation of translation, ncRNA-mediated (GO:0045974)3.06560686
102transcription elongation from RNA polymerase I promoter (GO:0006362)3.02357315
103kinetochore assembly (GO:0051382)3.01735898
104negative regulation of execution phase of apoptosis (GO:1900118)2.98861907
105melanin biosynthetic process (GO:0042438)2.96240238
106melanin metabolic process (GO:0006582)2.89348532
107negative regulation of DNA-dependent DNA replication (GO:2000104)2.88348174
108centriole assembly (GO:0098534)2.88108268
109GPI anchor metabolic process (GO:0006505)2.84963727
110amino sugar catabolic process (GO:0046348)2.84280516
111epithelial cilium movement (GO:0003351)2.83908435
112centriole replication (GO:0007099)2.80246944
113nonmotile primary cilium assembly (GO:0035058)2.80098027
114termination of RNA polymerase I transcription (GO:0006363)2.78543615
115glucosamine-containing compound catabolic process (GO:1901072)2.78349763
116kinetochore organization (GO:0051383)2.77674747
117positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.76919252
118mesenchymal cell differentiation involved in renal system development (GO:2001012)2.74925184
119mesenchymal cell differentiation involved in kidney development (GO:0072161)2.74925184
120termination of RNA polymerase III transcription (GO:0006386)2.72127676
121transcription elongation from RNA polymerase III promoter (GO:0006385)2.72127676
122DNA ligation (GO:0006266)2.71268972
123DNA integration (GO:0015074)2.71122109
124regulation of timing of cell differentiation (GO:0048505)2.71018331
125ribosomal large subunit biogenesis (GO:0042273)2.67754947
126protein heterotetramerization (GO:0051290)2.65832169
127photoreceptor cell maintenance (GO:0045494)2.63831135
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62999831
129cilium movement (GO:0003341)2.59072090
130histone H3-K4 trimethylation (GO:0080182)2.58339448
131regulation of meiosis I (GO:0060631)2.57064917
132sphingoid metabolic process (GO:0046519)2.56915791
133viral transcription (GO:0019083)2.55563055
134regulation of mRNA 3-end processing (GO:0031440)2.53732089
135negative regulation of leukocyte chemotaxis (GO:0002689)2.51089499
136positive regulation of mRNA 3-end processing (GO:0031442)2.50710414
137G-protein coupled receptor internalization (GO:0002031)2.49449393
138otic vesicle formation (GO:0030916)2.49059506
139C-terminal protein lipidation (GO:0006501)2.47840761
140histone H2B ubiquitination (GO:0033523)2.46987707
141translational termination (GO:0006415)2.46146722
142male meiosis (GO:0007140)2.45333504
143CENP-A containing nucleosome assembly (GO:0034080)2.43169957
144GTP biosynthetic process (GO:0006183)2.43137709
145regulation of nuclear cell cycle DNA replication (GO:0033262)2.42276703
146positive regulation of meiotic cell cycle (GO:0051446)2.40772432
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40262993
148regulation of mitotic spindle checkpoint (GO:1903504)2.40262993
149peptidyl-histidine modification (GO:0018202)2.39647768
150single strand break repair (GO:0000012)2.39324113
151limb bud formation (GO:0060174)2.38414368
152secondary metabolite biosynthetic process (GO:0044550)2.38072577
153regulation of development, heterochronic (GO:0040034)2.37937056
154male meiosis I (GO:0007141)2.37792009
155presynaptic membrane assembly (GO:0097105)2.37211922
156regulation of rhodopsin mediated signaling pathway (GO:0022400)2.36076899
157synapsis (GO:0007129)2.35821905
158spinal cord motor neuron differentiation (GO:0021522)2.35733409
159female gonad development (GO:0008585)2.35508931
160regulation of histone H3-K27 methylation (GO:0061085)2.32597123
161meiosis I (GO:0007127)2.31494415
162transcription initiation from RNA polymerase I promoter (GO:0006361)2.31393097
163protein K6-linked ubiquitination (GO:0085020)2.30522946
164multicellular organism reproduction (GO:0032504)2.29777160
165chromatin remodeling at centromere (GO:0031055)2.28283544
166* microtubule depolymerization (GO:0007019)2.28010947
167sphingosine metabolic process (GO:0006670)2.27941213
168retina layer formation (GO:0010842)2.26736763
169DNA synthesis involved in DNA repair (GO:0000731)2.26678556
170presynaptic membrane organization (GO:0097090)2.25762187
171establishment of skin barrier (GO:0061436)2.25036082
172rhodopsin mediated signaling pathway (GO:0016056)2.24247251
173phenol-containing compound catabolic process (GO:0019336)2.23877851
174diol metabolic process (GO:0034311)2.23801931
175transcription from RNA polymerase I promoter (GO:0006360)2.23231746
176pigmentation (GO:0043473)2.22590215
177mesonephros development (GO:0001823)2.22078714
178meiotic cell cycle (GO:0051321)2.22032751
179response to redox state (GO:0051775)2.21366924
180cranial nerve development (GO:0021545)2.20895402
181C-terminal protein amino acid modification (GO:0018410)2.19936877
182left/right axis specification (GO:0070986)2.19714645
1837-methylguanosine RNA capping (GO:0009452)2.19670970
184RNA capping (GO:0036260)2.19670970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human8.25711058
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.08172159
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87780374
4AR_21909140_ChIP-Seq_LNCAP_Human3.75285796
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.97958481
6E2F1_21310950_ChIP-Seq_MCF-7_Human2.96266286
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88616335
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.82534146
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82195110
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.67029257
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57656073
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57108118
13GBX2_23144817_ChIP-Seq_PC3_Human2.56883225
14EZH2_22144423_ChIP-Seq_EOC_Human2.43197024
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.37951407
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34087866
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31315610
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.26591330
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22563607
20NFE2_27457419_Chip-Seq_LIVER_Mouse2.20466370
21VDR_22108803_ChIP-Seq_LS180_Human2.12731780
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06801771
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05354303
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04364282
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92869750
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91600446
27FUS_26573619_Chip-Seq_HEK293_Human1.91250359
28XRN2_22483619_ChIP-Seq_HELA_Human1.89828655
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88708073
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.80904611
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79906017
32DCP1A_22483619_ChIP-Seq_HELA_Human1.78912472
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.78692728
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78465980
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.77349448
36IRF1_19129219_ChIP-ChIP_H3396_Human1.76464242
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74017793
38E2F7_22180533_ChIP-Seq_HELA_Human1.73987616
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73570846
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73340438
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.73307188
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72904109
43TAF15_26573619_Chip-Seq_HEK293_Human1.72597365
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.71136713
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69161923
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.68927850
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66346350
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65054809
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64754605
50E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.63668757
51RNF2_27304074_Chip-Seq_NSC_Mouse1.60335149
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.58585770
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.58251809
54NMYC_18555785_Chip-Seq_ESCs_Mouse1.58157675
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58122588
56* TTF2_22483619_ChIP-Seq_HELA_Human1.57188953
57RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56636791
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55527290
59P53_22387025_ChIP-Seq_ESCs_Mouse1.54074469
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52547847
61EWS_26573619_Chip-Seq_HEK293_Human1.52039315
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51687123
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51062446
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48436632
65P300_18555785_Chip-Seq_ESCs_Mouse1.48164578
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48002118
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.46666805
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.44661636
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43538650
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43449282
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.42700796
72KDM5A_27292631_Chip-Seq_BREAST_Human1.42549468
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.38989748
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.38026909
75ZFX_18555785_Chip-Seq_ESCs_Mouse1.37829605
76ER_23166858_ChIP-Seq_MCF-7_Human1.37301299
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.34542355
78GABP_19822575_ChIP-Seq_HepG2_Human1.34409272
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.33362775
80PU1_27457419_Chip-Seq_LIVER_Mouse1.30856335
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30598814
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.29994751
83ESRRB_18555785_Chip-Seq_ESCs_Mouse1.29431802
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29341559
85* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29249316
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28829341
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27758481
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.26090102
89P300_19829295_ChIP-Seq_ESCs_Human1.25944575
90SMAD1_18555785_Chip-Seq_ESCs_Mouse1.25759130
91* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25360369
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22167332
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21983230
94E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21345848
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21173608
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21173608
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.21068033
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20776822
99IGF1R_20145208_ChIP-Seq_DFB_Human1.20317085
100CTCF_18555785_Chip-Seq_ESCs_Mouse1.18911890
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.18279096
102* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17613960
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16026077
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15954688
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15327623
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.14714690
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14542217
108FOXP3_21729870_ChIP-Seq_TREG_Human1.14522831
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12685806
110VDR_23849224_ChIP-Seq_CD4+_Human1.10689508
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10132726
112EST1_17652178_ChIP-ChIP_JURKAT_Human1.09764858
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09626275
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.09271801
115SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08301761
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.07430710
117LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05974214
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05329796
119* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05246222
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04866347
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04396062
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04051441
123KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03561229
124CIITA_25753668_ChIP-Seq_RAJI_Human1.02910940
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02884003
126MYC_22102868_ChIP-Seq_BL_Human1.02477008
127* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02402472
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02023735
129KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01066434
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01066434
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01066434
132JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99674650
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.99300501
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99059000
135PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97091164
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96500674
137ELK1_19687146_ChIP-ChIP_HELA_Human0.94239008
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94192350
139TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93566842
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92900063
141ETV1_20927104_ChIP-Seq_GIST48_Human0.91968129
142CHD1_26751641_Chip-Seq_LNCaP_Human0.91435617
143KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90066723
144ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88773894
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.88667327
146SMAD4_21799915_ChIP-Seq_A2780_Human0.87958190
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87593323
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87273496
149GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87192230
150NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86626781
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86499217
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84229342
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83710410
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82210416
155MYC_18940864_ChIP-ChIP_HL60_Human0.81111085
156HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79554016
157ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76445168
158SOX2_16153702_ChIP-ChIP_HESCs_Human0.76065862
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74954703
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74768765
161NANOG_21062744_ChIP-ChIP_HESCs_Human0.72425849
162ZNF263_19887448_ChIP-Seq_K562_Human0.71824412
163DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71189135
164VDR_21846776_ChIP-Seq_THP-1_Human0.68549766
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67034272
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.65495026
167ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.64527364
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64445410
169KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.63845376
170SOX17_20123909_ChIP-Seq_XEN_Mouse0.62735334
171PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.60841954
172SRF_21415370_ChIP-Seq_HL-1_Mouse0.60162856
173CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.60014997
174NANOG_16153702_ChIP-ChIP_HESCs_Human0.59317923
175YY1_21170310_ChIP-Seq_MESCs_Mouse0.56869237
176* SOX9_26525672_Chip-Seq_HEART_Mouse0.54484298
177SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.53891855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.23014840
2MP0004381_abnormal_hair_follicle4.05487698
3MP0004957_abnormal_blastocyst_morpholog3.57779287
4MP0006292_abnormal_olfactory_placode3.40732058
5MP0001188_hyperpigmentation3.34965669
6MP0005409_darkened_coat_color3.21695641
7MP0002102_abnormal_ear_morphology2.80356531
8MP0005171_absent_coat_pigmentation2.75231811
9MP0008007_abnormal_cellular_replicative2.58856509
10MP0000372_irregular_coat_pigmentation2.57468681
11MP0000015_abnormal_ear_pigmentation2.37071012
12MP0008260_abnormal_autophagy2.36349052
13MP0008877_abnormal_DNA_methylation2.21750519
14MP0010307_abnormal_tumor_latency2.14483918
15MP0003941_abnormal_skin_development2.13693813
16MP0010030_abnormal_orbit_morphology2.13299956
17MP0005451_abnormal_body_composition2.12357034
18MP0001986_abnormal_taste_sensitivity2.12324969
19MP0002638_abnormal_pupillary_reflex2.07064277
20MP0000566_synostosis2.06751561
21MP0000383_abnormal_hair_follicle2.00185515
22MP0008058_abnormal_DNA_repair1.93944149
23MP0008057_abnormal_DNA_replication1.93084885
24MP0002163_abnormal_gland_morphology1.92286809
25MP0005174_abnormal_tail_pigmentation1.88727201
26MP0010094_abnormal_chromosome_stability1.88447045
27MP0000350_abnormal_cell_proliferation1.80861778
28MP0001529_abnormal_vocalization1.78000340
29MP0010352_gastrointestinal_tract_polyps1.75274746
30MP0003787_abnormal_imprinting1.75215885
31MP0005076_abnormal_cell_differentiation1.74949953
32MP0009379_abnormal_foot_pigmentation1.73938445
33MP0004742_abnormal_vestibular_system1.71820684
34MP0003693_abnormal_embryo_hatching1.67343628
35MP0005623_abnormal_meninges_morphology1.65479288
36MP0002095_abnormal_skin_pigmentation1.64709681
37MP0003718_maternal_effect1.60666636
38MP0001730_embryonic_growth_arrest1.59568733
39MP0001697_abnormal_embryo_size1.56802203
40MP0003111_abnormal_nucleus_morphology1.53309958
41MP0003880_abnormal_central_pattern1.50090132
42MP0009697_abnormal_copulation1.50077137
43MP0006072_abnormal_retinal_apoptosis1.48083676
44MP0005380_embryogenesis_phenotype1.47041593
45MP0001672_abnormal_embryogenesis/_devel1.47041593
46MP0005645_abnormal_hypothalamus_physiol1.46527924
47MP0003786_premature_aging1.45093814
48MP0005423_abnormal_somatic_nervous1.44468953
49MP0002085_abnormal_embryonic_tissue1.43993443
50MP0002084_abnormal_developmental_patter1.43258364
51MP0003938_abnormal_ear_development1.41144378
52MP0005379_endocrine/exocrine_gland_phen1.41012351
53MP0008995_early_reproductive_senescence1.40758618
54MP0002080_prenatal_lethality1.40736533
55MP0002009_preneoplasia1.37693801
56MP0004197_abnormal_fetal_growth/weight/1.37322646
57MP0005075_abnormal_melanosome_morpholog1.35867630
58MP0003950_abnormal_plasma_membrane1.35151071
59MP0003705_abnormal_hypodermis_morpholog1.35133727
60MP0002938_white_spotting1.33953612
61MP0000647_abnormal_sebaceous_gland1.29856519
62MP0002277_abnormal_respiratory_mucosa1.29661312
63MP0005410_abnormal_fertilization1.27844158
64MP0003890_abnormal_embryonic-extraembry1.26457682
65MP0000313_abnormal_cell_death1.25937641
66MP0010386_abnormal_urinary_bladder1.25760199
67MP0005551_abnormal_eye_electrophysiolog1.24979808
68MP0003984_embryonic_growth_retardation1.23352015
69MP0002160_abnormal_reproductive_system1.22351081
70MP0004233_abnormal_muscle_weight1.20532678
71MP0002088_abnormal_embryonic_growth/wei1.16299077
72MP0000026_abnormal_inner_ear1.15687068
73MP0001293_anophthalmia1.15491523
74MP0005377_hearing/vestibular/ear_phenot1.13822176
75MP0003878_abnormal_ear_physiology1.13822176
76MP0010678_abnormal_skin_adnexa1.13763341
77MP0005083_abnormal_biliary_tract1.11010352
78MP0002177_abnormal_outer_ear1.10293826
79MP0008789_abnormal_olfactory_epithelium1.09654337
80MP0003937_abnormal_limbs/digits/tail_de1.08787417
81MP0000428_abnormal_craniofacial_morphol1.07742907
82MP0002092_abnormal_eye_morphology1.07292106
83MP0002877_abnormal_melanocyte_morpholog1.07097294
84MP0002019_abnormal_tumor_incidence1.06277235
85MP0002751_abnormal_autonomic_nervous1.05609868
86MP0008932_abnormal_embryonic_tissue1.04452919
87MP0005253_abnormal_eye_physiology1.04326296
88MP0002210_abnormal_sex_determination1.04326104
89MP0009046_muscle_twitch1.04128256
90MP0002132_abnormal_respiratory_system1.03621952
91MP0002396_abnormal_hematopoietic_system1.03175893
92MP0002086_abnormal_extraembryonic_tissu1.02152551
93MP0002697_abnormal_eye_size0.98955831
94MP0000490_abnormal_crypts_of0.98117506
95MP0001905_abnormal_dopamine_level0.98029079
96MP0002234_abnormal_pharynx_morphology0.97711484
97MP0003698_abnormal_male_reproductive0.97430196
98MP0001186_pigmentation_phenotype0.96298051
99MP0001929_abnormal_gametogenesis0.96265997
100MP0004142_abnormal_muscle_tone0.93327433
101MP0001486_abnormal_startle_reflex0.91686550
102MP0005499_abnormal_olfactory_system0.90547431
103MP0005394_taste/olfaction_phenotype0.90547431
104MP0002111_abnormal_tail_morphology0.89527833
105MP0002752_abnormal_somatic_nervous0.88958254
106MP0000358_abnormal_cell_content/0.88590010
107MP0003656_abnormal_erythrocyte_physiolo0.88385769
108MP0002653_abnormal_ependyma_morphology0.87694598
109MP0003077_abnormal_cell_cycle0.87687240
110MP0001485_abnormal_pinna_reflex0.87200683
111MP0009703_decreased_birth_body0.86886753
112MP0003861_abnormal_nervous_system0.86475206
113MP0000049_abnormal_middle_ear0.85690044
114MP0000762_abnormal_tongue_morphology0.85034438
115MP0002161_abnormal_fertility/fecundity0.84819111
116MP0000631_abnormal_neuroendocrine_gland0.84560057
117MP0005408_hypopigmentation0.84068567
118MP0003121_genomic_imprinting0.83686452
119MP0003935_abnormal_craniofacial_develop0.83572417
120MP0001119_abnormal_female_reproductive0.83444686
121MP0004808_abnormal_hematopoietic_stem0.83439229
122MP0001346_abnormal_lacrimal_gland0.83420737
123MP0000537_abnormal_urethra_morphology0.83298807
124MP0003315_abnormal_perineum_morphology0.82729662
125MP0001984_abnormal_olfaction0.81613735
126MP0000432_abnormal_head_morphology0.81080177
127MP0006276_abnormal_autonomic_nervous0.80864462
128MP0002233_abnormal_nose_morphology0.80260237
129MP0001963_abnormal_hearing_physiology0.79796871
130MP0010234_abnormal_vibrissa_follicle0.79756048
131MP0002098_abnormal_vibrissa_morphology0.78940008
132MP0005395_other_phenotype0.78803377
133MP0001440_abnormal_grooming_behavior0.78494876
134MP0005621_abnormal_cell_physiology0.78314924
135MP0002249_abnormal_larynx_morphology0.77823219
136MP0000579_abnormal_nail_morphology0.77753737
137MP0003699_abnormal_female_reproductive0.77497992
138MP0001727_abnormal_embryo_implantation0.76816226
139MP0005501_abnormal_skin_physiology0.76382128
140MP0001145_abnormal_male_reproductive0.75767093
141MP0001661_extended_life_span0.75077403
142MP0000778_abnormal_nervous_system0.74920478
143MP0005384_cellular_phenotype0.74832312
144MP0001286_abnormal_eye_development0.74165318
145MP0009053_abnormal_anal_canal0.73087973
146MP0003755_abnormal_palate_morphology0.72756406
147MP0004185_abnormal_adipocyte_glucose0.72655716
148MP0009672_abnormal_birth_weight0.72410723
149MP0005391_vision/eye_phenotype0.72247128
150MP0003943_abnormal_hepatobiliary_system0.71638361
151MP0000653_abnormal_sex_gland0.70689204
152MP0002282_abnormal_trachea_morphology0.68433304
153MP0003942_abnormal_urinary_system0.65953645
154MP0002184_abnormal_innervation0.65772138
155MP0001324_abnormal_eye_pigmentation0.64799349
156MP0002272_abnormal_nervous_system0.63434804
157MP0000534_abnormal_ureter_morphology0.63278213
158MP0005257_abnormal_intraocular_pressure0.63002794
159MP0003385_abnormal_body_wall0.61729239
160MP0002075_abnormal_coat/hair_pigmentati0.60516029
161MP0000427_abnormal_hair_cycle0.59592950
162MP0005310_abnormal_salivary_gland0.59144747
163MP0002067_abnormal_sensory_capabilities0.59118955

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.49483868
2Chromsome breakage (HP:0040012)4.25482754
3Chronic bronchitis (HP:0004469)3.90481060
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.88534882
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.86694244
6Absent/shortened dynein arms (HP:0200106)3.86694244
7Bronchiectasis (HP:0002110)3.60890257
8Duplicated collecting system (HP:0000081)3.56235573
9Abnormality of the renal collecting system (HP:0004742)3.29618662
10Nasal polyposis (HP:0100582)3.25226385
11Abnormal ciliary motility (HP:0012262)3.14221725
12Abnormal respiratory epithelium morphology (HP:0012253)3.12401896
13Abnormal respiratory motile cilium morphology (HP:0005938)3.12401896
14Abnormal respiratory motile cilium physiology (HP:0012261)3.11020268
15Reticulocytopenia (HP:0001896)2.91731785
16Impulsivity (HP:0100710)2.86563398
17Congenital stationary night blindness (HP:0007642)2.86302129
18Abnormality of the preputium (HP:0100587)2.81058804
19Parakeratosis (HP:0001036)2.79178213
20Increased nuchal translucency (HP:0010880)2.71092029
21Sensory axonal neuropathy (HP:0003390)2.69865305
22Upper limb muscle weakness (HP:0003484)2.68441938
23Facial hemangioma (HP:0000329)2.68220319
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64654765
25Prostate neoplasm (HP:0100787)2.61369014
26Septo-optic dysplasia (HP:0100842)2.59377139
27Sloping forehead (HP:0000340)2.53240187
28Meckel diverticulum (HP:0002245)2.51445299
29Absent septum pellucidum (HP:0001331)2.48949614
30Volvulus (HP:0002580)2.47612555
31Male infertility (HP:0003251)2.47021762
32Abnormality of the duodenum (HP:0002246)2.45523245
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.43982380
34Abnormality of the ileum (HP:0001549)2.42438076
35Infertility (HP:0000789)2.41393329
36Abnormality of chromosome stability (HP:0003220)2.40515410
37Abnormality of the septum pellucidum (HP:0007375)2.39642985
38True hermaphroditism (HP:0010459)2.34705487
39Overlapping toe (HP:0001845)2.34666828
40Congenital sensorineural hearing impairment (HP:0008527)2.33715156
41Abnormality of the nasal mucosa (HP:0000433)2.32420451
42Concave nail (HP:0001598)2.29448495
43Abnormality of midbrain morphology (HP:0002418)2.29034795
44Molar tooth sign on MRI (HP:0002419)2.29034795
45Abnormality of DNA repair (HP:0003254)2.28285286
46Patellar aplasia (HP:0006443)2.24484577
47Duplication of thumb phalanx (HP:0009942)2.22789071
48Myelodysplasia (HP:0002863)2.22472335
49Pancreatic fibrosis (HP:0100732)2.21778948
50Conical tooth (HP:0000698)2.19680032
51Chronic hepatic failure (HP:0100626)2.19574498
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18938037
53White forelock (HP:0002211)2.16809269
54Medial flaring of the eyebrow (HP:0010747)2.16538138
55Abnormality of secondary sexual hair (HP:0009888)2.14963311
56Abnormality of the axillary hair (HP:0100134)2.14963311
57Triphalangeal thumb (HP:0001199)2.14071258
58Patchy hypopigmentation of hair (HP:0011365)2.11804993
59Median cleft lip (HP:0000161)2.11791141
60Nephronophthisis (HP:0000090)2.10334265
61Cafe-au-lait spot (HP:0000957)2.08891265
62Pancreatic cysts (HP:0001737)2.08713956
63Ectopic kidney (HP:0000086)2.06361189
64Aplasia/Hypoplasia of the patella (HP:0006498)2.04700267
65Abnormal number of incisors (HP:0011064)2.03328008
66Lip pit (HP:0100267)2.02630686
67Rhinitis (HP:0012384)2.02291210
68Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02136894
69Glioma (HP:0009733)2.01877442
70Hypothermia (HP:0002045)2.00037989
71Preaxial hand polydactyly (HP:0001177)2.00032432
72Absent radius (HP:0003974)1.98263408
73Aplasia/Hypoplasia of the fovea (HP:0008060)1.97905910
74Hypoplasia of the fovea (HP:0007750)1.97905910
75Embryonal renal neoplasm (HP:0011794)1.97811439
76Atelectasis (HP:0100750)1.97148532
77Ulnar bowing (HP:0003031)1.96768858
78Supernumerary spleens (HP:0009799)1.96093694
79Optic nerve hypoplasia (HP:0000609)1.95910745
80Poikiloderma (HP:0001029)1.95614339
81Broad distal phalanx of finger (HP:0009836)1.95567819
82Aganglionic megacolon (HP:0002251)1.95076840
83Deep philtrum (HP:0002002)1.95015571
84Clubbing of toes (HP:0100760)1.94654674
85Aplasia involving forearm bones (HP:0009822)1.94525341
86Absent forearm bone (HP:0003953)1.94525341
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.94457793
88Cortical dysplasia (HP:0002539)1.93947224
89Submucous cleft hard palate (HP:0000176)1.93555549
90Aplasia cutis congenita (HP:0001057)1.93081353
91Cupped ear (HP:0000378)1.92754273
92Tubulointerstitial nephritis (HP:0001970)1.90654062
93High anterior hairline (HP:0009890)1.89871575
94Anhidrosis (HP:0000970)1.89868119
95Short tibia (HP:0005736)1.89261789
96Squamous cell carcinoma (HP:0002860)1.88185348
97Abnormal sex determination (HP:0012244)1.87956674
98Sex reversal (HP:0012245)1.87956674
99Birth length less than 3rd percentile (HP:0003561)1.87579490
100Ureteral duplication (HP:0000073)1.87026309
101Renal agenesis (HP:0000104)1.86943215
102High pitched voice (HP:0001620)1.86553566
103Abnormality of the carotid arteries (HP:0005344)1.85490422
104Male pseudohermaphroditism (HP:0000037)1.85359661
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85258716
106Attenuation of retinal blood vessels (HP:0007843)1.83427869
107Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82220298
108Abnormality of the renal medulla (HP:0100957)1.82206184
109Prominent nose (HP:0000448)1.81937794
110Duodenal stenosis (HP:0100867)1.81822852
111Small intestinal stenosis (HP:0012848)1.81822852
112Short thumb (HP:0009778)1.81799860
113Pallor (HP:0000980)1.81069009
114Abnormality of chromosome segregation (HP:0002916)1.80819437
115Overfolded helix (HP:0000396)1.79880176
116Abnormality of cells of the erythroid lineage (HP:0012130)1.79544896
117Breast hypoplasia (HP:0003187)1.78808153
118Congenital primary aphakia (HP:0007707)1.76889583
119Macrocytic anemia (HP:0001972)1.74427575
120Proximal placement of thumb (HP:0009623)1.73982504
121Chin dimple (HP:0010751)1.72776305
122Medulloblastoma (HP:0002885)1.72668932
123Congenital ichthyosiform erythroderma (HP:0007431)1.72645899
124Absent epiphyses (HP:0010577)1.72302512
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72302512
126Recurrent otitis media (HP:0000403)1.72011792
127Absent thumb (HP:0009777)1.71869520
128Gait imbalance (HP:0002141)1.70901689
129Choanal atresia (HP:0000453)1.70899444
130Rhabdomyosarcoma (HP:0002859)1.70493669
131Optic nerve coloboma (HP:0000588)1.70170508
132Aplasia/Hypoplasia of the macula (HP:0008059)1.69792135
133Selective tooth agenesis (HP:0001592)1.68471595
134Astrocytoma (HP:0009592)1.68100153
135Abnormality of the astrocytes (HP:0100707)1.68100153
136Genital tract atresia (HP:0001827)1.68062493
137Chorioretinal coloboma (HP:0000567)1.67844449
138Arteriovenous malformation (HP:0100026)1.67661092
139Occipital encephalocele (HP:0002085)1.67245324
140Nephrogenic diabetes insipidus (HP:0009806)1.67162258
141Abnormally folded helix (HP:0008544)1.64964517
142Obsessive-compulsive behavior (HP:0000722)1.64954355
143Deviation of the thumb (HP:0009603)1.64845506
144Bell-shaped thorax (HP:0001591)1.64170082
145Abnormal lung lobation (HP:0002101)1.64045001
146Vaginal atresia (HP:0000148)1.63642737
147Abnormal number of erythroid precursors (HP:0012131)1.63632369
148Microvesicular hepatic steatosis (HP:0001414)1.63631062
149Ependymoma (HP:0002888)1.63561202
150Abnormality of the antihelix (HP:0009738)1.63033936
151Nephroblastoma (Wilms tumor) (HP:0002667)1.62970168
152Embryonal neoplasm (HP:0002898)1.59038330
153Facial cleft (HP:0002006)1.58790717
154Oligodactyly (hands) (HP:0001180)1.58252840
155Recurrent sinusitis (HP:0011108)1.56892532
156Heterotopia (HP:0002282)1.56492708
15711 pairs of ribs (HP:0000878)1.54553339
158Postaxial foot polydactyly (HP:0001830)1.54147961
159Bronchitis (HP:0012387)1.54000573
160Horseshoe kidney (HP:0000085)1.53405782
161Long clavicles (HP:0000890)1.53047467
162Neoplasm of striated muscle (HP:0009728)1.50083162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.43476211
2PNCK3.05815458
3MKNK23.04137191
4STK162.77838505
5CDK122.71882654
6SRPK12.69967252
7TLK12.20537880
8NEK22.20367507
9BRSK12.16281123
10ZAK2.14902440
11EIF2AK22.14417760
12MKNK12.08398042
13GRK12.01803445
14GRK71.89390524
15YES11.88047584
16TNIK1.87252368
17BUB11.87140008
18AKT31.85583843
19NEK11.80395971
20BLK1.76658158
21MAP3K101.76612978
22LATS11.72464894
23VRK11.70883611
24BRD41.67357102
25CDK31.65589965
26WEE11.60814103
27ICK1.60586861
28SMG11.58296149
29NEK61.50779995
30IRAK41.47350379
31IRAK31.43630505
32BMPR21.41395688
33PLK41.38254012
34BMPR1B1.37816752
35PBK1.36996521
36VRK21.34841105
37MAPK151.34443596
38NME21.31564425
39STK391.30743550
40CDK81.30029592
41MST1R1.29517112
42ADRBK21.29021479
43CLK11.27033218
44MAPKAPK51.16583616
45TXK1.11224598
46CAMK1G1.08758439
47PKN11.08748179
48MAP3K141.08710961
49MST41.08437694
50EEF2K1.07595199
51CDK41.07353091
52OXSR11.06560169
53IRAK21.06506348
54PLK31.05833343
55MAP3K81.05689596
56NUAK11.04872603
57TSSK61.04594039
58CHEK21.04426518
59STK31.03849107
60TAF11.03587456
61TTK1.01116849
62PLK11.00897541
63MET1.00504708
64SCYL20.94039033
65RPS6KB20.93192436
66MELK0.92961404
67CDK70.91850704
68RPS6KA50.91203070
69IRAK10.87437061
70PASK0.81668519
71WNK10.81543074
72AURKB0.79770173
73INSRR0.77492282
74ATR0.76255109
75CDK20.73527544
76AURKA0.73382639
77NEK90.72321287
78STK100.70933376
79TRIM280.67820904
80MUSK0.67268897
81TNK20.66517110
82EPHA20.65888667
83BCR0.65635712
84CAMK1D0.65592200
85IKBKB0.65286558
86TRPM70.64329538
87CDK60.62251199
88DYRK20.62195215
89EIF2AK30.60744193
90CDC70.60347087
91DYRK1A0.59822105
92STK40.57764314
93MAP2K70.57725824
94CAMK2D0.56922710
95MTOR0.56252663
96PLK20.56187987
97ATM0.55759380
98NLK0.54289587
99CAMK2B0.54279050
100IKBKE0.53234231
101PDK20.53208936
102PRKCI0.52870519
103CCNB10.52598660
104MAPK130.52250503
105TRIB30.51673985
106PRKCE0.51411030
107NME10.48703871
108CHEK10.47512263
109PRPF4B0.45639155
110MAPK110.43605675
111MAPK70.43209119
112RPS6KA40.43009676
113GRK50.42904207
114STK38L0.42798239
115PRKDC0.40519888
116DYRK30.40341123
117CDK10.39999325
118EPHA40.39862219
119TEC0.39388891
120ERBB30.38016386
121BRAF0.37031387
122PAK40.36386710
123FGR0.36295751
124MARK20.36259611
125EIF2AK10.35233904
126LYN0.34634866
127CSNK2A10.34386934
128PRKG10.33911597
129FES0.33904288
130MOS0.33665361
131NTRK20.32903003
132AKT20.32408930
133BRSK20.31019893
134CSNK2A20.30935148
135LCK0.30843119
136ERBB40.30463072
137BMX0.29900676
138MAPK140.29820383
139GSK3B0.29097781
140MARK30.28829123
141CDK90.28378726
142RIPK40.27972341
143CDK11A0.24559659
144CDK150.24083146
145CDK180.22999173

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.99688503
2Fanconi anemia pathway_Homo sapiens_hsa034602.93011902
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66939017
4RNA polymerase_Homo sapiens_hsa030202.66593408
5Homologous recombination_Homo sapiens_hsa034402.66589305
6Phototransduction_Homo sapiens_hsa047442.35831191
7Non-homologous end-joining_Homo sapiens_hsa034502.19443434
8One carbon pool by folate_Homo sapiens_hsa006702.18836273
9Basal transcription factors_Homo sapiens_hsa030222.11239485
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07653688
11Vitamin B6 metabolism_Homo sapiens_hsa007501.90144996
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90087559
13Sphingolipid metabolism_Homo sapiens_hsa006001.84154435
14Ether lipid metabolism_Homo sapiens_hsa005651.82348734
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73245399
16Oocyte meiosis_Homo sapiens_hsa041141.61521543
17Mismatch repair_Homo sapiens_hsa034301.59584087
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.57012176
19Linoleic acid metabolism_Homo sapiens_hsa005911.54400117
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52538432
21Arachidonic acid metabolism_Homo sapiens_hsa005901.50769209
22Nucleotide excision repair_Homo sapiens_hsa034201.48790214
23Spliceosome_Homo sapiens_hsa030401.39954818
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39215464
25Lysine degradation_Homo sapiens_hsa003101.32622166
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32291631
27Steroid biosynthesis_Homo sapiens_hsa001001.32141204
28Proteasome_Homo sapiens_hsa030501.29043945
29Pyrimidine metabolism_Homo sapiens_hsa002401.27720709
30Nicotine addiction_Homo sapiens_hsa050331.26039190
31Autoimmune thyroid disease_Homo sapiens_hsa053201.23031459
32Primary immunodeficiency_Homo sapiens_hsa053401.22287823
33Cell cycle_Homo sapiens_hsa041101.16549714
34Graft-versus-host disease_Homo sapiens_hsa053321.16293052
35Purine metabolism_Homo sapiens_hsa002301.15627160
36Serotonergic synapse_Homo sapiens_hsa047261.14040446
37Protein export_Homo sapiens_hsa030601.11242379
38Regulation of autophagy_Homo sapiens_hsa041401.10008302
39DNA replication_Homo sapiens_hsa030301.09200630
40Sulfur relay system_Homo sapiens_hsa041221.03763846
41Small cell lung cancer_Homo sapiens_hsa052221.03203786
42RNA transport_Homo sapiens_hsa030131.01503920
43Hematopoietic cell lineage_Homo sapiens_hsa046401.01417190
44Oxidative phosphorylation_Homo sapiens_hsa001901.01091448
45Taste transduction_Homo sapiens_hsa047421.00938468
46Biosynthesis of amino acids_Homo sapiens_hsa012301.00011126
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98874680
48Systemic lupus erythematosus_Homo sapiens_hsa053220.97913642
49p53 signaling pathway_Homo sapiens_hsa041150.97544807
50RNA degradation_Homo sapiens_hsa030180.94595017
51Base excision repair_Homo sapiens_hsa034100.93523753
52Hippo signaling pathway_Homo sapiens_hsa043900.89388511
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89296048
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88762557
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.88061014
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87581660
57Huntingtons disease_Homo sapiens_hsa050160.85530849
58Rheumatoid arthritis_Homo sapiens_hsa053230.84931174
59Alcoholism_Homo sapiens_hsa050340.80930123
60Allograft rejection_Homo sapiens_hsa053300.80202517
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79897321
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78818598
63Pyruvate metabolism_Homo sapiens_hsa006200.78081161
64TGF-beta signaling pathway_Homo sapiens_hsa043500.78045342
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.76339135
66mRNA surveillance pathway_Homo sapiens_hsa030150.75309091
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75055270
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74890018
69Thyroid cancer_Homo sapiens_hsa052160.74636353
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73424032
71Folate biosynthesis_Homo sapiens_hsa007900.73028051
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72731097
73Chronic myeloid leukemia_Homo sapiens_hsa052200.70224011
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.69961106
75Adherens junction_Homo sapiens_hsa045200.69641646
76Asthma_Homo sapiens_hsa053100.68008967
77Fatty acid elongation_Homo sapiens_hsa000620.66724718
78N-Glycan biosynthesis_Homo sapiens_hsa005100.66564823
79Collecting duct acid secretion_Homo sapiens_hsa049660.65574396
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65455071
81Pancreatic cancer_Homo sapiens_hsa052120.65263215
82Hedgehog signaling pathway_Homo sapiens_hsa043400.63804884
83HTLV-I infection_Homo sapiens_hsa051660.63712056
84Bladder cancer_Homo sapiens_hsa052190.63196555
85Glutamatergic synapse_Homo sapiens_hsa047240.61628208
86Morphine addiction_Homo sapiens_hsa050320.61349846
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60615454
88Malaria_Homo sapiens_hsa051440.60520721
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.60258603
90Glutathione metabolism_Homo sapiens_hsa004800.59343599
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59144806
92Non-small cell lung cancer_Homo sapiens_hsa052230.58996916
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58479670
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58093012
95Axon guidance_Homo sapiens_hsa043600.57388092
96Epstein-Barr virus infection_Homo sapiens_hsa051690.56061833
97Wnt signaling pathway_Homo sapiens_hsa043100.54841103
98Herpes simplex infection_Homo sapiens_hsa051680.54759482
99Colorectal cancer_Homo sapiens_hsa052100.54622887
100Basal cell carcinoma_Homo sapiens_hsa052170.53080002
101Selenocompound metabolism_Homo sapiens_hsa004500.53000180
102Carbon metabolism_Homo sapiens_hsa012000.52734862
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51466364
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49792717
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49789116
106Measles_Homo sapiens_hsa051620.49664809
107Notch signaling pathway_Homo sapiens_hsa043300.48422981
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47964216
109Alzheimers disease_Homo sapiens_hsa050100.47887589
110Pentose phosphate pathway_Homo sapiens_hsa000300.46744319
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.45339363
112Cocaine addiction_Homo sapiens_hsa050300.44992656
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44271317
114Vitamin digestion and absorption_Homo sapiens_hsa049770.43848491
115Mineral absorption_Homo sapiens_hsa049780.42253188
116Parkinsons disease_Homo sapiens_hsa050120.42057692
117Long-term depression_Homo sapiens_hsa047300.41640718
118Phenylalanine metabolism_Homo sapiens_hsa003600.41314113
119Fructose and mannose metabolism_Homo sapiens_hsa000510.40950177
120Melanoma_Homo sapiens_hsa052180.40529327
121Ras signaling pathway_Homo sapiens_hsa040140.40487186
122Amphetamine addiction_Homo sapiens_hsa050310.40463416
123T cell receptor signaling pathway_Homo sapiens_hsa046600.40365422
124Calcium signaling pathway_Homo sapiens_hsa040200.39998570
125Inositol phosphate metabolism_Homo sapiens_hsa005620.38571628
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36509141
127MicroRNAs in cancer_Homo sapiens_hsa052060.35913763
128Circadian rhythm_Homo sapiens_hsa047100.35826283
129Ovarian steroidogenesis_Homo sapiens_hsa049130.35597693
130Dorso-ventral axis formation_Homo sapiens_hsa043200.34814252
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34748731
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33684797
133Endometrial cancer_Homo sapiens_hsa052130.33002303
134Prostate cancer_Homo sapiens_hsa052150.32262128
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31874689
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31767612
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31292701
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30967826
139Glioma_Homo sapiens_hsa052140.30378254
140African trypanosomiasis_Homo sapiens_hsa051430.30332998
141Viral carcinogenesis_Homo sapiens_hsa052030.30320716
142mTOR signaling pathway_Homo sapiens_hsa041500.29980388
143Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29734536
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29650870
145Gap junction_Homo sapiens_hsa045400.29426949
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.29210674
147Retinol metabolism_Homo sapiens_hsa008300.28927753
148Other glycan degradation_Homo sapiens_hsa005110.28903534
149Pathways in cancer_Homo sapiens_hsa052000.28898642
150Tyrosine metabolism_Homo sapiens_hsa003500.26392343
151Hepatitis B_Homo sapiens_hsa051610.26365245
152Apoptosis_Homo sapiens_hsa042100.25904105
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23365550
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21929744
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19896688
156Tight junction_Homo sapiens_hsa045300.19539973
157Fatty acid biosynthesis_Homo sapiens_hsa000610.18154000
158Proteoglycans in cancer_Homo sapiens_hsa052050.17606348
159Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17378640

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