KIF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)8.72403114
2retinal cone cell development (GO:0046549)6.16798764
3keratinocyte development (GO:0003334)5.47561160
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.45852662
5L-phenylalanine catabolic process (GO:0006559)5.45852662
6Sertoli cell development (GO:0060009)5.04161097
7regulation of meiosis I (GO:0060631)4.93113351
8C4-dicarboxylate transport (GO:0015740)4.85373888
9positive regulation of histone H3-K4 methylation (GO:0051571)4.73048937
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.64506136
11L-phenylalanine metabolic process (GO:0006558)4.64506136
12apical protein localization (GO:0045176)4.08014807
13synapsis (GO:0007129)4.04186524
14cell fate commitment involved in formation of primary germ layer (GO:0060795)4.02847549
15response to nitrosative stress (GO:0051409)3.88696347
16tyrosine metabolic process (GO:0006570)3.85549590
17arginine catabolic process (GO:0006527)3.76594047
18regulation of hippo signaling (GO:0035330)3.75730334
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.75395051
20reciprocal DNA recombination (GO:0035825)3.74575817
21reciprocal meiotic recombination (GO:0007131)3.74575817
22protein K11-linked deubiquitination (GO:0035871)3.71563894
23piRNA metabolic process (GO:0034587)3.66885573
24DNA catabolic process, exonucleolytic (GO:0000738)3.63491615
25response to hydroperoxide (GO:0033194)3.58224131
26auditory receptor cell stereocilium organization (GO:0060088)3.51458697
27peptidyl-histidine modification (GO:0018202)3.51068971
28double-strand break repair via homologous recombination (GO:0000724)3.50906774
29intra-Golgi vesicle-mediated transport (GO:0006891)3.49972222
30peptidyl-lysine trimethylation (GO:0018023)3.49440539
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.47082999
32regulation of translation, ncRNA-mediated (GO:0045974)3.47082999
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.47082999
34recombinational repair (GO:0000725)3.46273537
35meiotic cell cycle (GO:0051321)3.43571147
36replication fork processing (GO:0031297)3.34765630
37histone H3-K4 trimethylation (GO:0080182)3.34692653
38regulation of hexokinase activity (GO:1903299)3.33386571
39regulation of glucokinase activity (GO:0033131)3.33386571
40aromatic amino acid family catabolic process (GO:0009074)3.33260216
41adaptation of signaling pathway (GO:0023058)3.30012898
42respiratory chain complex IV assembly (GO:0008535)3.26459605
43glycerophospholipid catabolic process (GO:0046475)3.22553585
44fatty acid elongation (GO:0030497)3.20709562
45regulation of gene silencing by RNA (GO:0060966)3.20222482
46regulation of posttranscriptional gene silencing (GO:0060147)3.20222482
47regulation of gene silencing by miRNA (GO:0060964)3.20222482
48positive regulation of meiosis (GO:0045836)3.17279579
49xenobiotic catabolic process (GO:0042178)3.12704017
50embryonic body morphogenesis (GO:0010172)3.07562772
51serine family amino acid catabolic process (GO:0009071)3.06225722
52DNA integration (GO:0015074)3.01038089
53interleukin-6-mediated signaling pathway (GO:0070102)3.00948009
54acrosome assembly (GO:0001675)3.00592346
55oligosaccharide biosynthetic process (GO:0009312)2.98130390
56histone H2B ubiquitination (GO:0033523)2.97707414
57negative regulation of viral entry into host cell (GO:0046597)2.97382088
58inner ear receptor stereocilium organization (GO:0060122)2.93167779
59positive regulation of meiotic cell cycle (GO:0051446)2.88422311
60positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.87836958
61cornea development in camera-type eye (GO:0061303)2.86167961
62proteasome assembly (GO:0043248)2.84503636
63interferon-gamma secretion (GO:0072643)2.84379296
64DNA methylation involved in gamete generation (GO:0043046)2.84372169
65positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.80343358
66mannosylation (GO:0097502)2.78356122
67water-soluble vitamin biosynthetic process (GO:0042364)2.76655671
68short-chain fatty acid metabolic process (GO:0046459)2.73451935
69axoneme assembly (GO:0035082)2.73243153
70lipid particle organization (GO:0034389)2.72047403
71regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.71486927
72multicellular organism reproduction (GO:0032504)2.70897179
73histone H3-K4 methylation (GO:0051568)2.69862844
74zinc ion transport (GO:0006829)2.66941144
75positive regulation of dendritic spine morphogenesis (GO:0061003)2.61362267
76phosphorelay signal transduction system (GO:0000160)2.59478096
77positive regulation of protein autophosphorylation (GO:0031954)2.58419790
78negative regulation of DNA-dependent DNA replication (GO:2000104)2.57871315
79regulation of cytokine production involved in inflammatory response (GO:1900015)2.56269130
80body morphogenesis (GO:0010171)2.56218449
81photoreceptor cell development (GO:0042461)2.55552154
82polarized epithelial cell differentiation (GO:0030859)2.55552016
83aggressive behavior (GO:0002118)2.55147603
84DNA replication initiation (GO:0006270)2.53108236
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.52540108
86platelet dense granule organization (GO:0060155)2.52005339
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51661339
88sympathetic nervous system development (GO:0048485)2.51119152
89positive regulation of prostaglandin secretion (GO:0032308)2.50539709
90negative regulation of viral release from host cell (GO:1902187)2.50450821
91regulation of acyl-CoA biosynthetic process (GO:0050812)2.48642543
92collecting duct development (GO:0072044)2.48240776
93detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42873222
94positive regulation of male gonad development (GO:2000020)2.42749010
95pyrimidine nucleobase catabolic process (GO:0006208)2.42178369
96regulation of lipoprotein metabolic process (GO:0050746)2.40777686
97oocyte development (GO:0048599)2.37984422
98negative regulation of complement activation (GO:0045916)2.37710815
99interferon-gamma production (GO:0032609)2.37611977
100microtubule bundle formation (GO:0001578)2.36577521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.74222562
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30197226
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86219374
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.59934432
5P300_19829295_ChIP-Seq_ESCs_Human2.45816455
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41054667
7EWS_26573619_Chip-Seq_HEK293_Human2.33364930
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29185894
9ZNF274_21170338_ChIP-Seq_K562_Hela2.26445175
10GBX2_23144817_ChIP-Seq_PC3_Human2.22529460
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12887123
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11892430
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11883385
14FUS_26573619_Chip-Seq_HEK293_Human2.09223433
15TAF15_26573619_Chip-Seq_HEK293_Human2.08120925
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01943994
17EZH2_22144423_ChIP-Seq_EOC_Human1.97972226
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95414792
19SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.93530642
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91209761
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.91196833
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87260785
23STAT3_23295773_ChIP-Seq_U87_Human1.86058106
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79816147
25ELK1_19687146_ChIP-ChIP_HELA_Human1.75458682
26CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73331769
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71870106
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.70776473
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70652856
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.68935446
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66649278
32ER_23166858_ChIP-Seq_MCF-7_Human1.66509630
33VDR_22108803_ChIP-Seq_LS180_Human1.65345436
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61648756
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57284357
36SMAD4_21799915_ChIP-Seq_A2780_Human1.55816972
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55248088
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.53102244
39AR_25329375_ChIP-Seq_VCAP_Human1.53023455
40BCAT_22108803_ChIP-Seq_LS180_Human1.49560712
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49334467
42* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47967866
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47072235
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46508638
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45099206
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.44823845
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44752102
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44440463
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42859326
50CBP_20019798_ChIP-Seq_JUKART_Human1.42859326
51TCF4_23295773_ChIP-Seq_U87_Human1.41538743
52CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.40495484
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39413044
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36290672
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33800415
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33334675
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.31199757
58ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29800051
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.29326311
60TCF4_22108803_ChIP-Seq_LS180_Human1.27147584
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.25022579
62* SMAD4_21741376_ChIP-Seq_EPCs_Human1.24813893
63TP53_22573176_ChIP-Seq_HFKS_Human1.23859761
64FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22749191
65AR_21572438_ChIP-Seq_LNCaP_Human1.21523305
66RNF2_27304074_Chip-Seq_NSC_Mouse1.20571164
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20222821
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18725137
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.18203945
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.17677004
71AHR_22903824_ChIP-Seq_MCF-7_Human1.17608022
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17168815
73NCOR_22424771_ChIP-Seq_293T_Human1.16602407
74SOX2_19829295_ChIP-Seq_ESCs_Human1.15230444
75NANOG_19829295_ChIP-Seq_ESCs_Human1.15230444
76RUNX2_22187159_ChIP-Seq_PCA_Human1.13075845
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11762250
78HTT_18923047_ChIP-ChIP_STHdh_Human1.09274168
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08978902
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07407980
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.07407980
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07398119
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.07221307
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06667241
85EOMES_21245162_ChIP-Seq_HESCs_Human1.05939038
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.04808002
87TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04452692
88* SMAD3_21741376_ChIP-Seq_ESCs_Human1.03547573
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03356893
90* FOXH1_21741376_ChIP-Seq_EPCs_Human1.03020105
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.02732036
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02181912
93CDX2_22108803_ChIP-Seq_LS180_Human1.01708396
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01175738
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00586251
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.99858321
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.99669603
98MYC_18940864_ChIP-ChIP_HL60_Human0.98148647
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94979048
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94879793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.92068304
2MP0008877_abnormal_DNA_methylation3.50605894
3MP0008057_abnormal_DNA_replication3.28950544
4MP0002653_abnormal_ependyma_morphology3.17207118
5MP0002009_preneoplasia2.84910310
6MP0003787_abnormal_imprinting2.68377677
7MP0003011_delayed_dark_adaptation2.59303956
8MP0005670_abnormal_white_adipose2.48516756
9MP0008007_abnormal_cellular_replicative2.38852656
10MP0010094_abnormal_chromosome_stability2.36940444
11MP0006072_abnormal_retinal_apoptosis2.21259274
12MP0000427_abnormal_hair_cycle2.14076324
13MP0006292_abnormal_olfactory_placode2.04255818
14MP0005408_hypopigmentation2.03692955
15MP0005551_abnormal_eye_electrophysiolog1.96653987
16MP0004215_abnormal_myocardial_fiber1.95747008
17MP0005075_abnormal_melanosome_morpholog1.92728564
18MP0004134_abnormal_chest_morphology1.88258621
19MP0003880_abnormal_central_pattern1.87866842
20MP0002160_abnormal_reproductive_system1.84081918
21MP0001486_abnormal_startle_reflex1.83704650
22MP0005253_abnormal_eye_physiology1.79837181
23MP0003693_abnormal_embryo_hatching1.78192601
24MP0005171_absent_coat_pigmentation1.73206449
25MP0002095_abnormal_skin_pigmentation1.72190586
26MP0003186_abnormal_redox_activity1.57993696
27MP0000647_abnormal_sebaceous_gland1.54863308
28MP0005410_abnormal_fertilization1.53593963
29MP0010307_abnormal_tumor_latency1.53231613
30MP0002938_white_spotting1.52119196
31MP0000015_abnormal_ear_pigmentation1.39723421
32MP0000383_abnormal_hair_follicle1.33220284
33MP0009697_abnormal_copulation1.32900411
34MP0009780_abnormal_chondrocyte_physiolo1.29816642
35MP0004084_abnormal_cardiac_muscle1.29415575
36MP0003137_abnormal_impulse_conducting1.26459282
37MP0003698_abnormal_male_reproductive1.25829756
38MP0000778_abnormal_nervous_system1.24798854
39MP0001929_abnormal_gametogenesis1.24506499
40MP0009046_muscle_twitch1.21795414
41MP0004147_increased_porphyrin_level1.21545041
42MP0000371_diluted_coat_color1.20776189
43MP0002127_abnormal_cardiovascular_syste1.20530765
44MP0008789_abnormal_olfactory_epithelium1.18858091
45MP0000569_abnormal_digit_pigmentation1.17962165
46MP0005248_abnormal_Harderian_gland1.17906477
47MP0002210_abnormal_sex_determination1.16891030
48MP0002557_abnormal_social/conspecific_i1.16787327
49MP0000631_abnormal_neuroendocrine_gland1.15941983
50MP0003136_yellow_coat_color1.14527390
51MP0002638_abnormal_pupillary_reflex1.14037464
52MP0002272_abnormal_nervous_system1.11026237
53MP0002102_abnormal_ear_morphology1.08959623
54MP0001145_abnormal_male_reproductive1.08506092
55MP0006054_spinal_hemorrhage1.08066699
56MP0005389_reproductive_system_phenotype1.08028195
57MP0000653_abnormal_sex_gland1.07542063
58MP0002233_abnormal_nose_morphology1.04110013
59MP0009745_abnormal_behavioral_response1.03044622
60MP0001984_abnormal_olfaction1.02891747
61MP0003718_maternal_effect1.02026327
62MP0001485_abnormal_pinna_reflex1.01507511
63MP0005174_abnormal_tail_pigmentation1.00045668
64MP0002090_abnormal_vision0.99057734
65MP0002098_abnormal_vibrissa_morphology0.98639336
66MP0003121_genomic_imprinting0.98156340
67MP0001293_anophthalmia0.98061445
68MP0002064_seizures0.97402977
69MP0004270_analgesia0.96928364
70MP0005423_abnormal_somatic_nervous0.95293305
71MP0008875_abnormal_xenobiotic_pharmacok0.94609404
72MP0001501_abnormal_sleep_pattern0.92700910
73MP0005332_abnormal_amino_acid0.91315149
74MP0006276_abnormal_autonomic_nervous0.89821100
75MP0003943_abnormal_hepatobiliary_system0.89256821
76MP0002254_reproductive_system_inflammat0.88342585
77MP0001881_abnormal_mammary_gland0.88300727
78MP0002184_abnormal_innervation0.86057962
79MP0000749_muscle_degeneration0.83970878
80MP0009053_abnormal_anal_canal0.83657926
81MP0004085_abnormal_heartbeat0.83150783
82MP0001968_abnormal_touch/_nociception0.83117789
83MP0010678_abnormal_skin_adnexa0.82550856
84MP0000372_irregular_coat_pigmentation0.81130001
85MP0002295_abnormal_pulmonary_circulatio0.81028736
86MP0006036_abnormal_mitochondrial_physio0.80740477
87MP0004145_abnormal_muscle_electrophysio0.79590929
88MP0002736_abnormal_nociception_after0.78473007
89MP0005394_taste/olfaction_phenotype0.78183884
90MP0005499_abnormal_olfactory_system0.78183884
91MP0001764_abnormal_homeostasis0.77957260
92MP0008775_abnormal_heart_ventricle0.76560093
93MP0008058_abnormal_DNA_repair0.74206913
94MP0002909_abnormal_adrenal_gland0.73591692
95MP0001324_abnormal_eye_pigmentation0.72304633
96MP0002572_abnormal_emotion/affect_behav0.72279938
97MP0003567_abnormal_fetal_cardiomyocyte0.71294319
98MP0001119_abnormal_female_reproductive0.70519573
99MP0005195_abnormal_posterior_eye0.69195120
100MP0003936_abnormal_reproductive_system0.68863420

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic islet-cell hyperplasia (HP:0004510)4.67835911
2Ectopic kidney (HP:0000086)4.57003266
3Pendular nystagmus (HP:0012043)4.28899157
4Microglossia (HP:0000171)4.23375475
5Short middle phalanx of the 5th finger (HP:0004220)4.19268463
6Abnormal finger flexion creases (HP:0006143)4.00609108
7Depressed nasal tip (HP:0000437)3.92168003
8Abnormality of the pancreatic islet cells (HP:0006476)3.72393039
9Abnormality of endocrine pancreas physiology (HP:0012093)3.72393039
10Volvulus (HP:0002580)3.57811097
11Aplasia/Hypoplasia of the tongue (HP:0010295)3.44693057
12Nonprogressive disorder (HP:0003680)3.38197642
13Pancreatic cysts (HP:0001737)3.26932914
14Failure to thrive in infancy (HP:0001531)3.26240005
15Horizontal nystagmus (HP:0000666)3.22109475
16Progressive microcephaly (HP:0000253)3.21968900
17Absent phalangeal crease (HP:0006109)3.17239098
18True hermaphroditism (HP:0010459)3.13401429
19Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95241085
20Pancreatic fibrosis (HP:0100732)2.90268086
21Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.82415315
22High pitched voice (HP:0001620)2.65654118
23Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.61675210
24Hyperinsulinemic hypoglycemia (HP:0000825)2.59323220
25Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.58449942
26Infantile muscular hypotonia (HP:0008947)2.57862191
27Molar tooth sign on MRI (HP:0002419)2.55260581
28Abnormality of midbrain morphology (HP:0002418)2.55260581
29Abnormality of the phalanges of the 5th finger (HP:0004213)2.42614897
30Abnormality of the lower motor neuron (HP:0002366)2.41489957
31Albinism (HP:0001022)2.40297538
32Nephronophthisis (HP:0000090)2.37548636
33Ketoacidosis (HP:0001993)2.37340142
34Hypoglycemic coma (HP:0001325)2.37034990
35Postaxial foot polydactyly (HP:0001830)2.32912979
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32795544
37Abnormal protein N-linked glycosylation (HP:0012347)2.32795544
38Abnormal protein glycosylation (HP:0012346)2.32795544
39Abnormal glycosylation (HP:0012345)2.32795544
40Renal Fanconi syndrome (HP:0001994)2.32615591
41Intestinal atresia (HP:0011100)2.25055616
42Acute hepatic failure (HP:0006554)2.25048903
43Fatigable weakness (HP:0003473)2.21803888
44Abnormality of the neuromuscular junction (HP:0003398)2.21803888
45Hypophosphatemic rickets (HP:0004912)2.19426217
46Hypoglycemic seizures (HP:0002173)2.19217596
47Lip pit (HP:0100267)2.18343115
48Proximal amyotrophy (HP:0007126)2.16352740
49Limb dystonia (HP:0002451)2.15882276
50Severe Myopia (HP:0011003)2.15166430
51Cystic liver disease (HP:0006706)2.14369875
52Dandy-Walker malformation (HP:0001305)2.13512627
53Myoglobinuria (HP:0002913)2.13269246
54Popliteal pterygium (HP:0009756)2.11869282
55Gaze-evoked nystagmus (HP:0000640)2.10300765
56Pterygium (HP:0001059)2.08135079
57Median cleft lip (HP:0000161)2.07904022
58Chronic hepatic failure (HP:0100626)2.07668905
59Anencephaly (HP:0002323)2.01797989
60Abnormal biliary tract physiology (HP:0012439)1.99744828
61Bile duct proliferation (HP:0001408)1.99744828
62Abnormality of methionine metabolism (HP:0010901)1.99526548
63Vertebral clefting (HP:0008428)1.98511417
64Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.95887874
65Aplasia/Hypoplasia of the earlobes (HP:0009906)1.93635439
66Fair hair (HP:0002286)1.93049079
67Medial flaring of the eyebrow (HP:0010747)1.91753735
68Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.90419961
69Hyperventilation (HP:0002883)1.89364874
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88898609
71Abnormality of alanine metabolism (HP:0010916)1.88898609
72Hyperalaninemia (HP:0003348)1.88898609
73Tented upper lip vermilion (HP:0010804)1.82580618
74Abnormality of the ileum (HP:0001549)1.81415747
75Abnormality of the renal medulla (HP:0100957)1.79180723
76Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75431359
77Gait imbalance (HP:0002141)1.74734920
78Hyperglycinuria (HP:0003108)1.73328510
79Hepatic necrosis (HP:0002605)1.72463404
80Congenital primary aphakia (HP:0007707)1.72246646
81Ileus (HP:0002595)1.72178398
82Male pseudohermaphroditism (HP:0000037)1.71628219
83White forelock (HP:0002211)1.70530509
84Degeneration of the lateral corticospinal tracts (HP:0002314)1.69670253
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69670253
86Frequent falls (HP:0002359)1.68832468
87Poor head control (HP:0002421)1.68163044
88Hyperkalemia (HP:0002153)1.67742069
89Short 5th finger (HP:0009237)1.67738396
90Tachypnea (HP:0002789)1.67006472
91Occipital encephalocele (HP:0002085)1.66701811
92Absent septum pellucidum (HP:0001331)1.66432089
93Thickened helices (HP:0000391)1.65919520
94Abnormality of the epiphyses of the hand (HP:0005924)1.65800266
95Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65485549
96Abnormality of the vocal cords (HP:0008777)1.65082195
9711 pairs of ribs (HP:0000878)1.64785283
98Narrow forehead (HP:0000341)1.63148589
99Hyperglycinemia (HP:0002154)1.63125577
100Rimmed vacuoles (HP:0003805)1.62272501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK9.70598772
2EIF2AK32.50232836
3INSRR2.36176354
4FRK2.14775054
5MAP3K42.05343886
6PAK31.97943453
7TNIK1.93164106
8PHKG21.89152040
9PHKG11.89152040
10PNCK1.87288539
11PINK11.86069973
12NUAK11.83499015
13FER1.83418072
14ZAK1.55968557
15TRIM281.48555754
16BRSK21.44169350
17MAP3K21.36674611
18PLK21.35526979
19MAPK131.34975173
20NTRK31.34184074
21AKT31.29734197
22EEF2K1.27767164
23PKN11.25864256
24MAP3K121.25085974
25STK391.22515559
26MAPKAPK31.19590235
27STK38L1.14367066
28BMPR1B1.11808069
29GRK11.11188816
30MARK31.09695847
31WNK31.07276841
32EPHA41.04987522
33DYRK31.03313539
34ATR1.00521238
35LATS10.99220142
36PLK30.99173793
37CASK0.98909392
38MAPKAPK50.90312286
39OBSCN0.89594735
40CAMK1G0.85063715
41ACVR1B0.82673119
42PIK3CA0.80044751
43STK30.77136008
44OXSR10.76416194
45PRKCE0.75744846
46GSK3A0.75500474
47SRPK10.73342324
48DAPK20.72336362
49PRKAA20.72068749
50CSNK1G20.71768819
51MAP4K20.69879607
52YES10.63941936
53CSNK1G10.62134518
54CAMK2A0.62054057
55TRPM70.61198300
56ERBB30.60086871
57CAMK10.59260751
58PRKAA10.58501431
59CHEK20.58136136
60CSNK1G30.57762452
61MARK10.56676309
62TIE10.56494684
63PLK10.55642663
64DYRK20.54768038
65FLT30.52986412
66PRKACB0.52274389
67PLK40.50975563
68MAP3K30.50923299
69HIPK20.50645416
70NLK0.50413512
71ADRBK20.48594658
72ERBB20.48194146
73EPHA30.47259666
74FGFR10.46721914
75TNK20.46514746
76MYLK0.45789299
77PBK0.44870419
78ABL10.43826201
79PRKCG0.43239162
80PRKD10.43182702
81MKNK20.41805057
82ATM0.40073766
83GRK50.39859388
84CDK190.39740537
85PRKDC0.39552499
86RPS6KB10.39163421
87MAP2K70.39155027
88IRAK20.38897345
89CSNK1A1L0.38710659
90MST40.38561921
91CDK60.38324515
92PRKG10.37863713
93TLK10.35735566
94PRKCI0.35359161
95SGK20.32377888
96MINK10.31400327
97VRK10.31029044
98WEE10.30194234
99UHMK10.30174218
100IRAK10.29266810

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.48260865
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.92422499
3Homologous recombination_Homo sapiens_hsa034402.98886646
4Vitamin B6 metabolism_Homo sapiens_hsa007502.97105735
5Protein export_Homo sapiens_hsa030602.36872269
6Propanoate metabolism_Homo sapiens_hsa006402.31035993
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25539227
8Butanoate metabolism_Homo sapiens_hsa006502.25476878
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18790755
10Selenocompound metabolism_Homo sapiens_hsa004502.17423622
11Fanconi anemia pathway_Homo sapiens_hsa034602.08576585
12Oxidative phosphorylation_Homo sapiens_hsa001901.99041301
13Fatty acid metabolism_Homo sapiens_hsa012121.82962923
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70087859
15Parkinsons disease_Homo sapiens_hsa050121.64892443
16beta-Alanine metabolism_Homo sapiens_hsa004101.64109224
17Non-homologous end-joining_Homo sapiens_hsa034501.63099115
18Basal transcription factors_Homo sapiens_hsa030221.58254890
19Cardiac muscle contraction_Homo sapiens_hsa042601.58150768
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54311988
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49309427
22RNA polymerase_Homo sapiens_hsa030201.46962019
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42356427
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41259727
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37906768
26Fatty acid degradation_Homo sapiens_hsa000711.33260548
27Glutathione metabolism_Homo sapiens_hsa004801.32590163
28Huntingtons disease_Homo sapiens_hsa050161.31986499
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.25982186
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.18783867
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17380144
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14233080
33Oocyte meiosis_Homo sapiens_hsa041141.14036316
34Lysine degradation_Homo sapiens_hsa003101.13802186
35Insulin secretion_Homo sapiens_hsa049111.12767511
36Tyrosine metabolism_Homo sapiens_hsa003501.11182332
37Tryptophan metabolism_Homo sapiens_hsa003801.06773084
38Mismatch repair_Homo sapiens_hsa034301.06016154
39Regulation of autophagy_Homo sapiens_hsa041401.05527305
40RNA degradation_Homo sapiens_hsa030181.02134655
41Nicotine addiction_Homo sapiens_hsa050330.99427232
42Steroid biosynthesis_Homo sapiens_hsa001000.98298713
43Sulfur metabolism_Homo sapiens_hsa009200.96612024
44Linoleic acid metabolism_Homo sapiens_hsa005910.94521866
45Proteasome_Homo sapiens_hsa030500.93613231
46N-Glycan biosynthesis_Homo sapiens_hsa005100.93233031
47Alzheimers disease_Homo sapiens_hsa050100.93220476
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90086400
49Nitrogen metabolism_Homo sapiens_hsa009100.88509560
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87970232
51Peroxisome_Homo sapiens_hsa041460.87939118
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87674150
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87158590
54Ether lipid metabolism_Homo sapiens_hsa005650.83458639
55Collecting duct acid secretion_Homo sapiens_hsa049660.82002616
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81314307
57Base excision repair_Homo sapiens_hsa034100.79875892
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76482773
59Morphine addiction_Homo sapiens_hsa050320.76225459
60Chemical carcinogenesis_Homo sapiens_hsa052040.75507707
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75415445
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.74705162
63Ovarian steroidogenesis_Homo sapiens_hsa049130.74519240
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73735597
65Glycerolipid metabolism_Homo sapiens_hsa005610.73567952
66Circadian rhythm_Homo sapiens_hsa047100.72505064
67RNA transport_Homo sapiens_hsa030130.71424580
68Cell cycle_Homo sapiens_hsa041100.65055586
69Retinol metabolism_Homo sapiens_hsa008300.61515803
70Dorso-ventral axis formation_Homo sapiens_hsa043200.60369403
71Folate biosynthesis_Homo sapiens_hsa007900.60207586
72Metabolic pathways_Homo sapiens_hsa011000.59882965
73Phototransduction_Homo sapiens_hsa047440.57367438
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56552814
75GABAergic synapse_Homo sapiens_hsa047270.54068777
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53677549
77Circadian entrainment_Homo sapiens_hsa047130.52870312
78Mineral absorption_Homo sapiens_hsa049780.52057848
79DNA replication_Homo sapiens_hsa030300.51510762
80PPAR signaling pathway_Homo sapiens_hsa033200.46756738
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46134108
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.45748195
83Sulfur relay system_Homo sapiens_hsa041220.45473246
84p53 signaling pathway_Homo sapiens_hsa041150.44392541
85Purine metabolism_Homo sapiens_hsa002300.43158818
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41105032
87Taste transduction_Homo sapiens_hsa047420.40754343
88Fat digestion and absorption_Homo sapiens_hsa049750.40752293
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38780093
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38688037
91Pyrimidine metabolism_Homo sapiens_hsa002400.37686465
92Arginine and proline metabolism_Homo sapiens_hsa003300.36911371
93Olfactory transduction_Homo sapiens_hsa047400.34955043
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34604876
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34128750
96Arachidonic acid metabolism_Homo sapiens_hsa005900.33294488
97Thyroid hormone synthesis_Homo sapiens_hsa049180.31975865
98Tight junction_Homo sapiens_hsa045300.31215960
99Histidine metabolism_Homo sapiens_hsa003400.31103479
100Nucleotide excision repair_Homo sapiens_hsa034200.30772158

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