

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cardiac chamber formation (GO:0003207) | 4.71826656 |
| 2 | axon extension involved in axon guidance (GO:0048846) | 4.47929355 |
| 3 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 4.47929355 |
| 4 | regulation of cardioblast differentiation (GO:0051890) | 4.22837433 |
| 5 | metanephric mesenchyme development (GO:0072075) | 4.20397076 |
| 6 | cardiac ventricle formation (GO:0003211) | 4.13092420 |
| 7 | bone trabecula formation (GO:0060346) | 4.09451617 |
| 8 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 4.02269322 |
| 9 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 3.97496219 |
| 10 | myofibril assembly (GO:0030239) | 3.92509032 |
| 11 | kidney mesenchyme development (GO:0072074) | 3.90123206 |
| 12 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.88312840 |
| 13 | axonal fasciculation (GO:0007413) | 3.83445633 |
| 14 | regulation of axon extension involved in axon guidance (GO:0048841) | 3.71925598 |
| 15 | atrial septum morphogenesis (GO:0060413) | 3.64360740 |
| 16 | mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337) | 3.59685561 |
| 17 | negative regulation of axon guidance (GO:1902668) | 3.57499836 |
| 18 | negative regulation of catenin import into nucleus (GO:0035414) | 3.51802357 |
| 19 | regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095) | 3.50687514 |
| 20 | chondrocyte proliferation (GO:0035988) | 3.49386944 |
| 21 | regulation of axon guidance (GO:1902667) | 3.49053894 |
| 22 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.45319668 |
| 23 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.42550105 |
| 24 | outflow tract septum morphogenesis (GO:0003148) | 3.40660089 |
| 25 | outer ear morphogenesis (GO:0042473) | 3.37565057 |
| 26 | cell migration in hindbrain (GO:0021535) | 3.36254090 |
| 27 | body morphogenesis (GO:0010171) | 3.29601438 |
| 28 | establishment of nucleus localization (GO:0040023) | 3.29584416 |
| 29 | hippo signaling (GO:0035329) | 3.29207182 |
| 30 | cell proliferation involved in metanephros development (GO:0072203) | 3.25053934 |
| 31 | regulation of cardioblast proliferation (GO:0003264) | 3.24867961 |
| 32 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 3.24867961 |
| 33 | lateral sprouting from an epithelium (GO:0060601) | 3.24200686 |
| 34 | head development (GO:0060322) | 3.20903289 |
| 35 | craniofacial suture morphogenesis (GO:0097094) | 3.20680817 |
| 36 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.20358542 |
| 37 | venous blood vessel morphogenesis (GO:0048845) | 3.13035398 |
| 38 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 3.10548537 |
| 39 | layer formation in cerebral cortex (GO:0021819) | 3.09566280 |
| 40 | cardiac myofibril assembly (GO:0055003) | 3.09510340 |
| 41 | negative regulation of hormone biosynthetic process (GO:0032353) | 3.07078627 |
| 42 | proximal/distal pattern formation (GO:0009954) | 3.06658487 |
| 43 | cartilage morphogenesis (GO:0060536) | 3.05840459 |
| 44 | myelination in peripheral nervous system (GO:0022011) | 3.05582426 |
| 45 | peripheral nervous system axon ensheathment (GO:0032292) | 3.05582426 |
| 46 | neuron recognition (GO:0008038) | 3.01806371 |
| 47 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.01545003 |
| 48 | paraxial mesoderm development (GO:0048339) | 3.00476716 |
| 49 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.00014266 |
| 50 | response to pheromone (GO:0019236) | 2.98508865 |
| 51 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 2.98327935 |
| 52 | camera-type eye morphogenesis (GO:0048593) | 2.97784692 |
| 53 | negative chemotaxis (GO:0050919) | 2.97529192 |
| 54 | regulation of establishment of planar polarity (GO:0090175) | 2.97429071 |
| 55 | dendritic spine morphogenesis (GO:0060997) | 2.92579192 |
| 56 | collagen fibril organization (GO:0030199) | 2.91211532 |
| 57 | endocardial cushion development (GO:0003197) | 2.90686234 |
| 58 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.89865445 |
| 59 | adult heart development (GO:0007512) | 2.88890350 |
| 60 | embryonic skeletal joint morphogenesis (GO:0060272) | 2.88783915 |
| 61 | sympathetic nervous system development (GO:0048485) | 2.88546416 |
| 62 | dendrite morphogenesis (GO:0048813) | 2.87572616 |
| 63 | midgut development (GO:0007494) | 2.87545252 |
| 64 | chondrocyte development (GO:0002063) | 2.84265994 |
| 65 | polarized epithelial cell differentiation (GO:0030859) | 2.83408649 |
| 66 | regulation of non-canonical Wnt signaling pathway (GO:2000050) | 2.82868493 |
| 67 | coronary vasculature morphogenesis (GO:0060977) | 2.81364188 |
| 68 | heart morphogenesis (GO:0003007) | 2.80363032 |
| 69 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.80111300 |
| 70 | mesenchyme morphogenesis (GO:0072132) | 2.79248632 |
| 71 | plasma membrane repair (GO:0001778) | 2.79220897 |
| 72 | axon extension (GO:0048675) | 2.78195860 |
| 73 | hindlimb morphogenesis (GO:0035137) | 2.75940477 |
| 74 | cardiac muscle cell development (GO:0055013) | 2.75743338 |
| 75 | dermatan sulfate biosynthetic process (GO:0030208) | 2.75556800 |
| 76 | locomotory exploration behavior (GO:0035641) | 2.74901252 |
| 77 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.74347037 |
| 78 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.73701969 |
| 79 | organ induction (GO:0001759) | 2.73269387 |
| 80 | cochlea morphogenesis (GO:0090103) | 2.72660770 |
| 81 | convergent extension (GO:0060026) | 2.71852449 |
| 82 | regulation of catenin import into nucleus (GO:0035412) | 2.70972328 |
| 83 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.69117934 |
| 84 | positive regulation of cardiac muscle tissue development (GO:0055025) | 2.68941362 |
| 85 | gastrulation with mouth forming second (GO:0001702) | 2.67939376 |
| 86 | cardiac cell development (GO:0055006) | 2.67670713 |
| 87 | pericardium development (GO:0060039) | 2.67127952 |
| 88 | regulation of the force of heart contraction (GO:0002026) | 2.67028995 |
| 89 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.66876443 |
| 90 | presynaptic membrane assembly (GO:0097105) | 2.65911798 |
| 91 | embryonic forelimb morphogenesis (GO:0035115) | 2.65680409 |
| 92 | protein heterotrimerization (GO:0070208) | 2.64834455 |
| 93 | middle ear morphogenesis (GO:0042474) | 2.64255349 |
| 94 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.63571186 |
| 95 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.62661834 |
| 96 | regulation of cardiac muscle cell apoptotic process (GO:0010665) | 2.62011258 |
| 97 | mesenchyme development (GO:0060485) | 2.61034149 |
| 98 | mesenchymal cell proliferation (GO:0010463) | 2.61027635 |
| 99 | positive regulation of cardiac muscle cell proliferation (GO:0060045) | 2.60295548 |
| 100 | embryonic hindlimb morphogenesis (GO:0035116) | 2.60208408 |
| 101 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 2.59993580 |
| 102 | mesenchymal to epithelial transition (GO:0060231) | 2.59274089 |
| 103 | cranial nerve morphogenesis (GO:0021602) | 2.58015684 |
| 104 | sarcomere organization (GO:0045214) | 2.56948468 |
| 105 | non-canonical Wnt signaling pathway (GO:0035567) | 2.56723822 |
| 106 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.55428742 |
| 107 | striated muscle hypertrophy (GO:0014897) | 2.54443847 |
| 108 | embryonic body morphogenesis (GO:0010172) | 2.54088551 |
| 109 | cell migration involved in heart development (GO:0060973) | 2.54055255 |
| 110 | forelimb morphogenesis (GO:0035136) | 2.53253240 |
| 111 | endocardial cushion morphogenesis (GO:0003203) | 2.52808517 |
| 112 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.52725901 |
| 113 | positive regulation of cardiac muscle tissue growth (GO:0055023) | 2.52601817 |
| 114 | heart valve formation (GO:0003188) | 2.52345756 |
| 115 | enteric nervous system development (GO:0048484) | 2.52339300 |
| 116 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.51825539 |
| 117 | positive regulation of heart growth (GO:0060421) | 2.51641210 |
| 118 | cell proliferation involved in kidney development (GO:0072111) | 2.51591382 |
| 119 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.51545557 |
| 120 | cardiac muscle hypertrophy (GO:0003300) | 2.51237684 |
| 121 | positive regulation of synapse assembly (GO:0051965) | 2.51209829 |
| 122 | negative regulation of embryonic development (GO:0045992) | 2.50181876 |
| 123 | regulation of organ formation (GO:0003156) | 2.49745058 |
| 124 | regulation of cardiac muscle cell differentiation (GO:2000725) | 2.49336282 |
| 125 | heart valve morphogenesis (GO:0003179) | 2.49291045 |
| 126 | collagen catabolic process (GO:0030574) | 2.48644983 |
| 127 | negative regulation of hormone metabolic process (GO:0032351) | 2.48555332 |
| 128 | regulation of nephron tubule epithelial cell differentiation (GO:0072182) | 2.48551666 |
| 129 | regulation of transforming growth factor beta2 production (GO:0032909) | 2.48121972 |
| 130 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.46446324 |
| 131 | central nervous system neuron axonogenesis (GO:0021955) | 2.45305570 |
| 132 | atrioventricular valve morphogenesis (GO:0003181) | 2.44794003 |
| 133 | innervation (GO:0060384) | 2.44704827 |
| 134 | exploration behavior (GO:0035640) | 2.44310254 |
| 135 | regulation of heart morphogenesis (GO:2000826) | 2.43914913 |
| 136 | limb morphogenesis (GO:0035108) | 2.43843850 |
| 137 | appendage morphogenesis (GO:0035107) | 2.43843850 |
| 138 | peripheral nervous system neuron development (GO:0048935) | 2.43709654 |
| 139 | nucleus localization (GO:0051647) | 2.43378734 |
| 140 | glial cell migration (GO:0008347) | 2.43089814 |
| 141 | dermatan sulfate metabolic process (GO:0030205) | 2.42848935 |
| 142 | embryonic appendage morphogenesis (GO:0035113) | 2.42432809 |
| 143 | embryonic limb morphogenesis (GO:0030326) | 2.42432809 |
| 144 | branching involved in ureteric bud morphogenesis (GO:0001658) | 2.42190335 |
| 145 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.40996401 |
| 146 | collagen metabolic process (GO:0032963) | 2.40976485 |
| 147 | cardiac septum morphogenesis (GO:0060411) | 2.40969756 |
| 148 | cell communication involved in cardiac conduction (GO:0086065) | 2.40625724 |
| 149 | auditory behavior (GO:0031223) | 2.39635399 |
| 150 | neuron cell-cell adhesion (GO:0007158) | 2.39624050 |
| 151 | cell communication by electrical coupling (GO:0010644) | 2.39197565 |
| 152 | synaptic vesicle maturation (GO:0016188) | 2.38965739 |
| 153 | postsynaptic membrane organization (GO:0001941) | 2.38902424 |
| 154 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.38443819 |
| 155 | regulation of synapse assembly (GO:0051963) | 2.37148450 |
| 156 | presynaptic membrane organization (GO:0097090) | 2.36536265 |
| 157 | suckling behavior (GO:0001967) | 2.36516357 |
| 158 | smooth muscle cell differentiation (GO:0051145) | 2.35112992 |
| 159 | developmental cell growth (GO:0048588) | 2.35055506 |
| 160 | cell junction maintenance (GO:0034331) | 2.33900190 |
| 161 | morphogenesis of an epithelial sheet (GO:0002011) | 2.32838974 |
| 162 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.31646016 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 3.57011279 |
| 2 | * EZH2_22144423_ChIP-Seq_EOC_Human | 3.37890273 |
| 3 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.92521781 |
| 4 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.92270889 |
| 5 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.92043553 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.88264541 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.88264541 |
| 8 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.82775861 |
| 9 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.81157715 |
| 10 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.80682576 |
| 11 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.53317452 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.52614123 |
| 13 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.51721192 |
| 14 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.45421882 |
| 15 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.37292384 |
| 16 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.33345903 |
| 17 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 2.27871644 |
| 18 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.20608877 |
| 19 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.20015295 |
| 20 | * ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.17233563 |
| 21 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.02770693 |
| 22 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.01110079 |
| 23 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 2.00617170 |
| 24 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 2.00374484 |
| 25 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.95004380 |
| 26 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.94871453 |
| 27 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.88103112 |
| 28 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.87044872 |
| 29 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.83375702 |
| 30 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.76894854 |
| 31 | * EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.75690621 |
| 32 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.73586380 |
| 33 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.70389297 |
| 34 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.70096492 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.68289158 |
| 36 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.66748292 |
| 37 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.65106487 |
| 38 | * ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.64926650 |
| 39 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.63242174 |
| 40 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.61648954 |
| 41 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.61143208 |
| 42 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.61050627 |
| 43 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.61029825 |
| 44 | * ZNF274_21170338_ChIP-Seq_K562_Hela | 1.57736223 |
| 45 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.56324247 |
| 46 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.54766733 |
| 47 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.54097371 |
| 48 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.53520456 |
| 49 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.51774402 |
| 50 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.51730910 |
| 51 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.47496680 |
| 52 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.46411425 |
| 53 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.40382954 |
| 54 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.38298581 |
| 55 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.35153869 |
| 56 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.34875200 |
| 57 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.32057955 |
| 58 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31550404 |
| 59 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.31116661 |
| 60 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.29102933 |
| 61 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.24178816 |
| 62 | AR_19668381_ChIP-Seq_PC3_Human | 1.24163583 |
| 63 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.23724564 |
| 64 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.23233874 |
| 65 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.23161364 |
| 66 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.22773845 |
| 67 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.22654036 |
| 68 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.21487710 |
| 69 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.21002949 |
| 70 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.20179043 |
| 71 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.19553918 |
| 72 | * NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.19307441 |
| 73 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.17684260 |
| 74 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.16876367 |
| 75 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15967409 |
| 76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.14864704 |
| 77 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.14561969 |
| 78 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.13955990 |
| 79 | TP53_16413492_ChIP-PET_HCT116_Human | 1.13677024 |
| 80 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.13402355 |
| 81 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.12983822 |
| 82 | FUS_26573619_Chip-Seq_HEK293_Human | 1.12463427 |
| 83 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.12057012 |
| 84 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.11705492 |
| 85 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.11658000 |
| 86 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.11285735 |
| 87 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.07509600 |
| 88 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.07083127 |
| 89 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.05977240 |
| 90 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.05430859 |
| 91 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.05146523 |
| 92 | * NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.04628548 |
| 93 | * NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.04628548 |
| 94 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.04386968 |
| 95 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.04222085 |
| 96 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.04110994 |
| 97 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.03048064 |
| 98 | CJUN_26792858_Chip-Seq_BT549_Human | 1.03005201 |
| 99 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.00825618 |
| 100 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.00695513 |
| 101 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.00510698 |
| 102 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.00482638 |
| 103 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.99480211 |
| 104 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99248625 |
| 105 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.98646354 |
| 106 | * TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.98359814 |
| 107 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.98271785 |
| 108 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.98107023 |
| 109 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.98094016 |
| 110 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.95636038 |
| 111 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.95152911 |
| 112 | * CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.94762195 |
| 113 | * CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94655347 |
| 114 | EWS_26573619_Chip-Seq_HEK293_Human | 0.94620690 |
| 115 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.94476331 |
| 116 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94442192 |
| 117 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 0.93934363 |
| 118 | * TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.93673007 |
| 119 | * POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.93673007 |
| 120 | * ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.92953842 |
| 121 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.92307833 |
| 122 | AR_25329375_ChIP-Seq_VCAP_Human | 0.92249791 |
| 123 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.91998899 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003122_maternal_imprinting | 3.73211046 |
| 2 | MP0005503_abnormal_tendon_morphology | 3.49569146 |
| 3 | MP0008438_abnormal_cutaneous_collagen | 2.93941589 |
| 4 | MP0003385_abnormal_body_wall | 2.87666832 |
| 5 | MP0003123_paternal_imprinting | 2.69881088 |
| 6 | MP0009053_abnormal_anal_canal | 2.58224361 |
| 7 | MP0010030_abnormal_orbit_morphology | 2.44628089 |
| 8 | * MP0003942_abnormal_urinary_system | 2.43593624 |
| 9 | MP0009250_abnormal_appendicular_skeleto | 2.42510904 |
| 10 | MP0003121_genomic_imprinting | 2.41121096 |
| 11 | MP0000534_abnormal_ureter_morphology | 2.38175342 |
| 12 | MP0000537_abnormal_urethra_morphology | 2.28065789 |
| 13 | MP0002822_catalepsy | 2.25335080 |
| 14 | MP0004859_abnormal_synaptic_plasticity | 2.11279773 |
| 15 | MP0005623_abnormal_meninges_morphology | 1.98106089 |
| 16 | MP0003705_abnormal_hypodermis_morpholog | 1.93329873 |
| 17 | MP0000049_abnormal_middle_ear | 1.91253281 |
| 18 | MP0000569_abnormal_digit_pigmentation | 1.88766781 |
| 19 | MP0001299_abnormal_eye_distance/ | 1.88516926 |
| 20 | MP0002938_white_spotting | 1.85725064 |
| 21 | MP0005275_abnormal_skin_tensile | 1.82874338 |
| 22 | MP0009384_cardiac_valve_regurgitation | 1.75172233 |
| 23 | MP0004233_abnormal_muscle_weight | 1.74164391 |
| 24 | MP0004272_abnormal_basement_membrane | 1.70774902 |
| 25 | MP0002249_abnormal_larynx_morphology | 1.68752054 |
| 26 | MP0003755_abnormal_palate_morphology | 1.68467382 |
| 27 | MP0003279_aneurysm | 1.66438826 |
| 28 | MP0003937_abnormal_limbs/digits/tail_de | 1.62399923 |
| 29 | MP0000778_abnormal_nervous_system | 1.62268547 |
| 30 | MP0003935_abnormal_craniofacial_develop | 1.56801168 |
| 31 | MP0005409_darkened_coat_color | 1.56494240 |
| 32 | MP0002932_abnormal_joint_morphology | 1.55222045 |
| 33 | MP0000462_abnormal_digestive_system | 1.54037362 |
| 34 | MP0002102_abnormal_ear_morphology | 1.53593572 |
| 35 | MP0002184_abnormal_innervation | 1.51068201 |
| 36 | MP0003115_abnormal_respiratory_system | 1.50869405 |
| 37 | MP0002282_abnormal_trachea_morphology | 1.45698577 |
| 38 | MP0002735_abnormal_chemical_nociception | 1.42329041 |
| 39 | MP0000428_abnormal_craniofacial_morphol | 1.41655225 |
| 40 | MP0005187_abnormal_penis_morphology | 1.39950432 |
| 41 | MP0005508_abnormal_skeleton_morphology | 1.39178207 |
| 42 | MP0002116_abnormal_craniofacial_bone | 1.37734451 |
| 43 | MP0002233_abnormal_nose_morphology | 1.37296455 |
| 44 | MP0000733_abnormal_muscle_development | 1.31125329 |
| 45 | MP0002108_abnormal_muscle_morphology | 1.30941987 |
| 46 | MP0004145_abnormal_muscle_electrophysio | 1.30887484 |
| 47 | MP0003283_abnormal_digestive_organ | 1.30817935 |
| 48 | MP0003635_abnormal_synaptic_transmissio | 1.30349141 |
| 49 | MP0000751_myopathy | 1.29936438 |
| 50 | MP0004036_abnormal_muscle_relaxation | 1.23521020 |
| 51 | MP0002109_abnormal_limb_morphology | 1.21372437 |
| 52 | MP0004134_abnormal_chest_morphology | 1.20973321 |
| 53 | MP0005248_abnormal_Harderian_gland | 1.19912081 |
| 54 | MP0008775_abnormal_heart_ventricle | 1.18605807 |
| 55 | MP0000516_abnormal_urinary_system | 1.17947097 |
| 56 | MP0005367_renal/urinary_system_phenotyp | 1.17947097 |
| 57 | MP0004858_abnormal_nervous_system | 1.17727256 |
| 58 | MP0004270_analgesia | 1.17544138 |
| 59 | MP0003938_abnormal_ear_development | 1.16639887 |
| 60 | MP0005171_absent_coat_pigmentation | 1.16531734 |
| 61 | MP0004215_abnormal_myocardial_fiber | 1.15218741 |
| 62 | MP0004885_abnormal_endolymph | 1.15001539 |
| 63 | MP0003941_abnormal_skin_development | 1.14925799 |
| 64 | MP0002751_abnormal_autonomic_nervous | 1.13906135 |
| 65 | MP0000432_abnormal_head_morphology | 1.13130180 |
| 66 | MP0002697_abnormal_eye_size | 1.12725304 |
| 67 | MP0003091_abnormal_cell_migration | 1.10253463 |
| 68 | MP0003119_abnormal_digestive_system | 1.08575805 |
| 69 | MP0000762_abnormal_tongue_morphology | 1.07873684 |
| 70 | MP0003861_abnormal_nervous_system | 1.07860596 |
| 71 | MP0002114_abnormal_axial_skeleton | 1.06958416 |
| 72 | MP0000955_abnormal_spinal_cord | 1.05988618 |
| 73 | MP0004085_abnormal_heartbeat | 1.05344386 |
| 74 | MP0003787_abnormal_imprinting | 1.05131330 |
| 75 | MP0001958_emphysema | 1.01963603 |
| 76 | MP0002177_abnormal_outer_ear | 1.01520460 |
| 77 | MP0002089_abnormal_postnatal_growth/wei | 1.00982365 |
| 78 | MP0002127_abnormal_cardiovascular_syste | 1.00472407 |
| 79 | MP0001270_distended_abdomen | 1.00467519 |
| 80 | MP0000538_abnormal_urinary_bladder | 0.99330834 |
| 81 | MP0003567_abnormal_fetal_cardiomyocyte | 0.98919075 |
| 82 | MP0002115_abnormal_skeleton_extremities | 0.97456869 |
| 83 | MP0002896_abnormal_bone_mineralization | 0.97177254 |
| 84 | MP0001879_abnormal_lymphatic_vessel | 0.97003857 |
| 85 | MP0000566_synostosis | 0.95918292 |
| 86 | MP0009046_muscle_twitch | 0.95603144 |
| 87 | MP0002734_abnormal_mechanical_nocicepti | 0.95251046 |
| 88 | MP0000163_abnormal_cartilage_morphology | 0.94890286 |
| 89 | MP0001293_anophthalmia | 0.94729902 |
| 90 | MP0005620_abnormal_muscle_contractility | 0.94077401 |
| 91 | MP0006054_spinal_hemorrhage | 0.93888397 |
| 92 | MP0001340_abnormal_eyelid_morphology | 0.93250108 |
| 93 | MP0003137_abnormal_impulse_conducting | 0.92777887 |
| 94 | MP0002063_abnormal_learning/memory/cond | 0.92202614 |
| 95 | * MP0002081_perinatal_lethality | 0.92036785 |
| 96 | MP0004084_abnormal_cardiac_muscle | 0.91841858 |
| 97 | MP0003880_abnormal_central_pattern | 0.91658966 |
| 98 | MP0006138_congestive_heart_failure | 0.90894412 |
| 99 | MP0002972_abnormal_cardiac_muscle | 0.90481810 |
| 100 | MP0003890_abnormal_embryonic-extraembry | 0.89250386 |
| 101 | MP0009703_decreased_birth_body | 0.88932558 |
| 102 | MP0003878_abnormal_ear_physiology | 0.88006575 |
| 103 | MP0005377_hearing/vestibular/ear_phenot | 0.88006575 |
| 104 | MP0005257_abnormal_intraocular_pressure | 0.87153622 |
| 105 | MP0001348_abnormal_lacrimal_gland | 0.86987871 |
| 106 | MP0010630_abnormal_cardiac_muscle | 0.85248072 |
| 107 | MP0005197_abnormal_uvea_morphology | 0.83446002 |
| 108 | MP0004811_abnormal_neuron_physiology | 0.83379992 |
| 109 | MP0003045_fibrosis | 0.83289393 |
| 110 | MP0010386_abnormal_urinary_bladder | 0.82163489 |
| 111 | MP0006276_abnormal_autonomic_nervous | 0.81840815 |
| 112 | MP0005369_muscle_phenotype | 0.80813169 |
| 113 | MP0005076_abnormal_cell_differentiation | 0.80269892 |
| 114 | MP0002152_abnormal_brain_morphology | 0.80100526 |
| 115 | MP0002925_abnormal_cardiovascular_devel | 0.80018955 |
| 116 | MP0002572_abnormal_emotion/affect_behav | 0.79924265 |
| 117 | MP0002111_abnormal_tail_morphology | 0.78324751 |
| 118 | MP0002882_abnormal_neuron_morphology | 0.78171496 |
| 119 | MP0001177_atelectasis | 0.77932244 |
| 120 | MP0000767_abnormal_smooth_muscle | 0.77207000 |
| 121 | MP0000759_abnormal_skeletal_muscle | 0.77117140 |
| 122 | MP0001440_abnormal_grooming_behavior | 0.76470068 |
| 123 | MP0001968_abnormal_touch/_nociception | 0.76173232 |
| 124 | MP0002113_abnormal_skeleton_development | 0.76072301 |
| 125 | MP0002638_abnormal_pupillary_reflex | 0.75528899 |
| 126 | MP0002837_dystrophic_cardiac_calcinosis | 0.74756348 |
| 127 | MP0009780_abnormal_chondrocyte_physiolo | 0.74467630 |
| 128 | MP0002085_abnormal_embryonic_tissue | 0.73840266 |
| 129 | MP0004197_abnormal_fetal_growth/weight/ | 0.73807492 |
| 130 | MP0010368_abnormal_lymphatic_system | 0.73579605 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 5.06717233 |
| 2 | Short 4th metacarpal (HP:0010044) | 5.06717233 |
| 3 | Shallow orbits (HP:0000586) | 3.93846643 |
| 4 | Abnormality of the 4th metacarpal (HP:0010012) | 3.93063109 |
| 5 | Protrusio acetabuli (HP:0003179) | 3.85625615 |
| 6 | Renal duplication (HP:0000075) | 3.28429693 |
| 7 | Arterial tortuosity (HP:0005116) | 3.19511961 |
| 8 | Abnormality of the ischium (HP:0003174) | 3.18599176 |
| 9 | Broad metatarsal (HP:0001783) | 3.02901233 |
| 10 | Hypoplastic ischia (HP:0003175) | 2.92623763 |
| 11 | Hepatoblastoma (HP:0002884) | 2.91763004 |
| 12 | Premature rupture of membranes (HP:0001788) | 2.91697047 |
| 13 | Midline defect of the nose (HP:0004122) | 2.72025223 |
| 14 | Cutaneous finger syndactyly (HP:0010554) | 2.71828470 |
| 15 | Bladder diverticulum (HP:0000015) | 2.63266114 |
| 16 | Microglossia (HP:0000171) | 2.56342693 |
| 17 | Mild short stature (HP:0003502) | 2.52861747 |
| 18 | Asymmetry of the thorax (HP:0001555) | 2.47992272 |
| 19 | Hypoplasia of the iris (HP:0007676) | 2.45420946 |
| 20 | Overgrowth (HP:0001548) | 2.41352545 |
| 21 | Bell-shaped thorax (HP:0001591) | 2.36107224 |
| 22 | Cutaneous syndactyly (HP:0012725) | 2.33246568 |
| 23 | Coronal craniosynostosis (HP:0004440) | 2.31341942 |
| 24 | Wide anterior fontanel (HP:0000260) | 2.29675146 |
| 25 | Morphological abnormality of the middle ear (HP:0008609) | 2.27582839 |
| 26 | Atrial fibrillation (HP:0005110) | 2.25377020 |
| 27 | Bowel diverticulosis (HP:0005222) | 2.24705695 |
| 28 | Partial duplication of the phalanx of hand (HP:0009999) | 2.21421567 |
| 29 | Trigonocephaly (HP:0000243) | 2.19977124 |
| 30 | Mesomelia (HP:0003027) | 2.19305277 |
| 31 | Wrist flexion contracture (HP:0001239) | 2.18859856 |
| 32 | Broad thumb (HP:0011304) | 2.17526890 |
| 33 | Buphthalmos (HP:0000557) | 2.17121843 |
| 34 | Peritonitis (HP:0002586) | 2.16811073 |
| 35 | Lymphangioma (HP:0100764) | 2.14932836 |
| 36 | Syringomyelia (HP:0003396) | 2.13536148 |
| 37 | Spinal cord lesions (HP:0100561) | 2.13536148 |
| 38 | Ectopia lentis (HP:0001083) | 2.12615148 |
| 39 | Broad toe (HP:0001837) | 2.12208802 |
| 40 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.12142501 |
| 41 | Aplasia of the phalanges of the hand (HP:0009802) | 2.12142501 |
| 42 | Aplasia involving bones of the extremities (HP:0009825) | 2.12142501 |
| 43 | Broad long bones (HP:0005622) | 2.09561790 |
| 44 | Deviation of the hallux (HP:0010051) | 2.08659095 |
| 45 | Abnormality of the parietal bone (HP:0002696) | 2.08034458 |
| 46 | Narrow palate (HP:0000189) | 2.07214657 |
| 47 | Vitreoretinal degeneration (HP:0000655) | 2.07115609 |
| 48 | Broad ribs (HP:0000885) | 2.06379639 |
| 49 | Broad finger (HP:0001500) | 2.06192212 |
| 50 | Narrow nasal bridge (HP:0000446) | 2.06074601 |
| 51 | Atrophic scars (HP:0001075) | 2.05201123 |
| 52 | Sacral dimple (HP:0000960) | 2.04676117 |
| 53 | Ankle contracture (HP:0006466) | 2.04426578 |
| 54 | Genetic anticipation (HP:0003743) | 2.04223425 |
| 55 | Renovascular hypertension (HP:0100817) | 2.04114969 |
| 56 | Shawl scrotum (HP:0000049) | 2.03488901 |
| 57 | Primary atrial arrhythmia (HP:0001692) | 2.03383357 |
| 58 | Soft skin (HP:0000977) | 2.02892388 |
| 59 | Aortic dissection (HP:0002647) | 2.01641729 |
| 60 | Aortic aneurysm (HP:0004942) | 2.01089035 |
| 61 | Broad phalanx (HP:0006009) | 1.99943367 |
| 62 | Hypoplasia of the maxilla (HP:0000327) | 1.99515950 |
| 63 | Broad phalanges of the hand (HP:0009768) | 1.98960353 |
| 64 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.97103560 |
| 65 | Ventricular tachycardia (HP:0004756) | 1.96244532 |
| 66 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.93828350 |
| 67 | Abnormality of incisor morphology (HP:0011063) | 1.92859465 |
| 68 | Mitral valve prolapse (HP:0001634) | 1.92654182 |
| 69 | Hallux valgus (HP:0001822) | 1.91808103 |
| 70 | Dilatation of the ascending aorta (HP:0005111) | 1.91056993 |
| 71 | Aqueductal stenosis (HP:0002410) | 1.90738083 |
| 72 | Macroorchidism (HP:0000053) | 1.90317913 |
| 73 | Follicular hyperkeratosis (HP:0007502) | 1.90265103 |
| 74 | Blue sclerae (HP:0000592) | 1.89268667 |
| 75 | Supraventricular arrhythmia (HP:0005115) | 1.88416632 |
| 76 | Supraventricular tachycardia (HP:0004755) | 1.88050153 |
| 77 | Limited hip movement (HP:0008800) | 1.87945158 |
| 78 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.87841529 |
| 79 | Partial duplication of thumb phalanx (HP:0009944) | 1.87293932 |
| 80 | Turricephaly (HP:0000262) | 1.87276370 |
| 81 | Abnormality of dentin (HP:0010299) | 1.87230937 |
| 82 | Spondylolisthesis (HP:0003302) | 1.86971452 |
| 83 | Hyperacusis (HP:0010780) | 1.84608406 |
| 84 | Cerebral aneurysm (HP:0004944) | 1.84440514 |
| 85 | Pulmonary artery stenosis (HP:0004415) | 1.83508659 |
| 86 | Disproportionate tall stature (HP:0001519) | 1.83477481 |
| 87 | Increased number of teeth (HP:0011069) | 1.83391504 |
| 88 | Absent frontal sinuses (HP:0002688) | 1.81476950 |
| 89 | Flat cornea (HP:0007720) | 1.81431419 |
| 90 | Osteoarthritis (HP:0002758) | 1.80692120 |
| 91 | Hypoventilation (HP:0002791) | 1.80376872 |
| 92 | Cervical subluxation (HP:0003308) | 1.78552585 |
| 93 | Mitral regurgitation (HP:0001653) | 1.78118638 |
| 94 | Genu recurvatum (HP:0002816) | 1.77877411 |
| 95 | Preaxial foot polydactyly (HP:0001841) | 1.76857535 |
| 96 | Chorioretinal atrophy (HP:0000533) | 1.76630157 |
| 97 | Ulnar bowing (HP:0003031) | 1.75186832 |
| 98 | Diastasis recti (HP:0001540) | 1.75150575 |
| 99 | Aplasia/Hypoplasia of metatarsal bones (HP:0001964) | 1.74948898 |
| 100 | Hip contracture (HP:0003273) | 1.73760527 |
| 101 | Omphalocele (HP:0001539) | 1.73485525 |
| 102 | Short middle phalanx of the 5th finger (HP:0004220) | 1.72609925 |
| 103 | Pointed chin (HP:0000307) | 1.71748739 |
| 104 | Joint laxity (HP:0001388) | 1.71529195 |
| 105 | Anteriorly placed anus (HP:0001545) | 1.71184937 |
| 106 | Neonatal short-limb short stature (HP:0008921) | 1.69679637 |
| 107 | Elfin facies (HP:0004428) | 1.69571047 |
| 108 | Type 1 muscle fiber predominance (HP:0003803) | 1.69457678 |
| 109 | Patent foramen ovale (HP:0001655) | 1.68914431 |
| 110 | Action tremor (HP:0002345) | 1.68080521 |
| 111 | Abnormality of the aortic arch (HP:0012303) | 1.67542463 |
| 112 | Abnormality of the anterior chamber (HP:0000593) | 1.67062161 |
| 113 | Wide cranial sutures (HP:0010537) | 1.66864354 |
| 114 | Absent eyebrow (HP:0002223) | 1.66752590 |
| 115 | Hyperventilation (HP:0002883) | 1.66017504 |
| 116 | Fragile skin (HP:0001030) | 1.66014426 |
| 117 | Biconcave vertebral bodies (HP:0004586) | 1.65666125 |
| 118 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.65542267 |
| 119 | Broad palm (HP:0001169) | 1.61994582 |
| 120 | Increased nuchal translucency (HP:0010880) | 1.61877727 |
| 121 | Sudden death (HP:0001699) | 1.61579645 |
| 122 | Short metatarsal (HP:0010743) | 1.61516913 |
| 123 | Short 5th finger (HP:0009237) | 1.61125766 |
| 124 | Renal hypoplasia (HP:0000089) | 1.60322507 |
| 125 | Aplasia/Hypoplasia of the clavicles (HP:0006710) | 1.59839231 |
| 126 | Abnormality of the nasolacrimal system (HP:0000614) | 1.59485793 |
| 127 | Hyperextensible skin (HP:0000974) | 1.59133656 |
| 128 | Vascular tortuosity (HP:0004948) | 1.59036478 |
| 129 | Periauricular skin pits (HP:0100277) | 1.58843697 |
| 130 | Preauricular pit (HP:0004467) | 1.58843697 |
| 131 | Round face (HP:0000311) | 1.58808760 |
| 132 | Exostoses (HP:0100777) | 1.58747116 |
| 133 | Tracheomalacia (HP:0002779) | 1.58537457 |
| 134 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.58345355 |
| 135 | Short clavicles (HP:0000894) | 1.57511572 |
| 136 | Inguinal hernia (HP:0000023) | 1.56920624 |
| 137 | Wormian bones (HP:0002645) | 1.56760245 |
| 138 | Abnormality of the pubic bones (HP:0003172) | 1.56251819 |
| 139 | Hypoplastic labia majora (HP:0000059) | 1.55368434 |
| 140 | Overriding aorta (HP:0002623) | 1.55122317 |
| 141 | Abnormality of the 2nd finger (HP:0004100) | 1.55063671 |
| 142 | Broad hallux (HP:0010055) | 1.54879079 |
| 143 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.54421231 |
| 144 | Vertebral arch anomaly (HP:0008438) | 1.54408658 |
| 145 | Focal seizures (HP:0007359) | 1.54252237 |
| 146 | Bradycardia (HP:0001662) | 1.54243379 |
| 147 | Supernumerary ribs (HP:0005815) | 1.54192382 |
| 148 | Dental malocclusion (HP:0000689) | 1.53944030 |
| 149 | Infantile muscular hypotonia (HP:0008947) | 1.52711641 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 3.39439706 |
| 2 | EPHA3 | 2.95580975 |
| 3 | DDR2 | 2.92014319 |
| 4 | LATS2 | 2.81974624 |
| 5 | PDGFRA | 2.70693079 |
| 6 | EPHB2 | 2.46957507 |
| 7 | LATS1 | 2.43446413 |
| 8 | TNIK | 2.38751924 |
| 9 | NTRK3 | 2.33671584 |
| 10 | ERBB3 | 2.16467526 |
| 11 | FLT3 | 1.97991616 |
| 12 | TRIB3 | 1.95269324 |
| 13 | RIPK1 | 1.94462273 |
| 14 | MAP3K4 | 1.86170132 |
| 15 | MINK1 | 1.81696069 |
| 16 | MAP3K9 | 1.80500879 |
| 17 | OBSCN | 1.78425299 |
| 18 | FGFR2 | 1.73617246 |
| 19 | PRKD3 | 1.70758324 |
| 20 | NTRK2 | 1.68000840 |
| 21 | KSR1 | 1.64966232 |
| 22 | MAPK13 | 1.63131098 |
| 23 | MAPK15 | 1.54973981 |
| 24 | CAMK1G | 1.53646811 |
| 25 | EPHA4 | 1.51578304 |
| 26 | DMPK | 1.43113911 |
| 27 | WNK1 | 1.41097105 |
| 28 | FGFR1 | 1.40913157 |
| 29 | MYLK | 1.38495018 |
| 30 | TTN | 1.38471347 |
| 31 | PAK6 | 1.23385098 |
| 32 | STK38L | 1.19531699 |
| 33 | CDC42BPA | 1.17986402 |
| 34 | NTRK1 | 1.17830437 |
| 35 | PKN2 | 1.17377304 |
| 36 | ICK | 1.13432827 |
| 37 | DYRK2 | 1.12388823 |
| 38 | PHKG1 | 1.12257729 |
| 39 | PHKG2 | 1.12257729 |
| 40 | PAK3 | 1.11975467 |
| 41 | NEK9 | 1.11733211 |
| 42 | PLK2 | 1.08989826 |
| 43 | ERBB2 | 1.06959698 |
| 44 | TYRO3 | 1.05809618 |
| 45 | UHMK1 | 1.05502922 |
| 46 | MAP3K6 | 1.02364422 |
| 47 | CAMK1D | 1.00345478 |
| 48 | EEF2K | 0.98528986 |
| 49 | FER | 0.98132338 |
| 50 | LMTK2 | 0.94635057 |
| 51 | MAP2K4 | 0.91744749 |
| 52 | SIK1 | 0.91079252 |
| 53 | MTOR | 0.89968918 |
| 54 | SIK2 | 0.88850249 |
| 55 | RET | 0.88498713 |
| 56 | MAP2K7 | 0.88429082 |
| 57 | PIK3CA | 0.88179370 |
| 58 | LIMK1 | 0.87989124 |
| 59 | PTK2 | 0.86235196 |
| 60 | MET | 0.85725710 |
| 61 | STK38 | 0.85725612 |
| 62 | MAP3K10 | 0.85158564 |
| 63 | PDGFRB | 0.84716094 |
| 64 | CAMKK1 | 0.84011893 |
| 65 | ROCK1 | 0.83611743 |
| 66 | MKNK1 | 0.83198731 |
| 67 | CASK | 0.80555870 |
| 68 | CSNK1A1L | 0.80440202 |
| 69 | PRKD2 | 0.77020906 |
| 70 | ACVR1B | 0.76821640 |
| 71 | CDK12 | 0.76121154 |
| 72 | PAK2 | 0.76006961 |
| 73 | PRKCH | 0.75837629 |
| 74 | GRK7 | 0.74773403 |
| 75 | CAMK1 | 0.74272923 |
| 76 | TRPM7 | 0.74210038 |
| 77 | PTK6 | 0.73173737 |
| 78 | PRPF4B | 0.72544813 |
| 79 | STK24 | 0.71455398 |
| 80 | CAMK4 | 0.71007859 |
| 81 | MAPK7 | 0.70569560 |
| 82 | CSNK1G2 | 0.70168373 |
| 83 | RPS6KA2 | 0.69926091 |
| 84 | CDK18 | 0.69163374 |
| 85 | PRKCG | 0.67445745 |
| 86 | SGK2 | 0.67087474 |
| 87 | CDK5 | 0.66800181 |
| 88 | SGK3 | 0.65523764 |
| 89 | CDK14 | 0.65363610 |
| 90 | ADRBK1 | 0.64996888 |
| 91 | CDK15 | 0.64321432 |
| 92 | WNK3 | 0.62013979 |
| 93 | MARK2 | 0.59767030 |
| 94 | BRD4 | 0.58839490 |
| 95 | PNCK | 0.57591382 |
| 96 | MAPK12 | 0.57102584 |
| 97 | NLK | 0.57088769 |
| 98 | MAP3K7 | 0.56540682 |
| 99 | PLK3 | 0.56218945 |
| 100 | TAOK1 | 0.55860880 |
| 101 | BMPR1B | 0.55574713 |
| 102 | SIK3 | 0.55268966 |
| 103 | ILK | 0.55221006 |
| 104 | PRKD1 | 0.54074428 |
| 105 | CDK11A | 0.53038196 |
| 106 | CSNK1G3 | 0.52081307 |
| 107 | PKN1 | 0.51677244 |
| 108 | MAPK8 | 0.51090182 |
| 109 | CSNK1G1 | 0.50959921 |
| 110 | AKT3 | 0.50957928 |
| 111 | FRK | 0.50328947 |
| 112 | SGK494 | 0.50026865 |
| 113 | SGK223 | 0.50026865 |
| 114 | INSRR | 0.49050855 |
| 115 | ROCK2 | 0.48895311 |
| 116 | MAPK9 | 0.48664273 |
| 117 | STK3 | 0.48607351 |
| 118 | BCR | 0.48547468 |
| 119 | PTK2B | 0.47141611 |
| 120 | CAMK2A | 0.47009636 |
| 121 | NEK1 | 0.46687284 |
| 122 | MAPK10 | 0.41884813 |
| 123 | ALK | 0.41785391 |
| 124 | TAOK2 | 0.41479510 |
| 125 | PRKCE | 0.41393995 |
| 126 | PRKAA1 | 0.40632544 |
| 127 | CAMKK2 | 0.39862956 |
| 128 | DYRK1A | 0.38061079 |
| 129 | GSK3A | 0.35169638 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.43640871 |
| 2 | Axon guidance_Homo sapiens_hsa04360 | 2.22065789 |
| 3 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 2.21104785 |
| 4 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 2.12153306 |
| 5 | Nicotine addiction_Homo sapiens_hsa05033 | 1.97882799 |
| 6 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.93006612 |
| 7 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.85226083 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 1.77751946 |
| 9 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.70722305 |
| 10 | Melanogenesis_Homo sapiens_hsa04916 | 1.69025078 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.67848517 |
| 12 | Long-term potentiation_Homo sapiens_hsa04720 | 1.66809864 |
| 13 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.64872139 |
| 14 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.62836975 |
| 15 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.59841067 |
| 16 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.59790926 |
| 17 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.51807166 |
| 18 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.50570105 |
| 19 | Gap junction_Homo sapiens_hsa04540 | 1.50195773 |
| 20 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.48789321 |
| 21 | Focal adhesion_Homo sapiens_hsa04510 | 1.47563257 |
| 22 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.46855672 |
| 23 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.46720337 |
| 24 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.43934717 |
| 25 | Glioma_Homo sapiens_hsa05214 | 1.43775872 |
| 26 | GABAergic synapse_Homo sapiens_hsa04727 | 1.41068530 |
| 27 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.41068042 |
| 28 | Adherens junction_Homo sapiens_hsa04520 | 1.40472970 |
| 29 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.40402064 |
| 30 | Long-term depression_Homo sapiens_hsa04730 | 1.39070498 |
| 31 | Endometrial cancer_Homo sapiens_hsa05213 | 1.34985262 |
| 32 | Cocaine addiction_Homo sapiens_hsa05030 | 1.33110126 |
| 33 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.32954310 |
| 34 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.32814157 |
| 35 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.32705164 |
| 36 | Colorectal cancer_Homo sapiens_hsa05210 | 1.32550846 |
| 37 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.31611678 |
| 38 | Olfactory transduction_Homo sapiens_hsa04740 | 1.27979246 |
| 39 | Morphine addiction_Homo sapiens_hsa05032 | 1.20361516 |
| 40 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.20103879 |
| 41 | Renin secretion_Homo sapiens_hsa04924 | 1.19661424 |
| 42 | Insulin secretion_Homo sapiens_hsa04911 | 1.19331884 |
| 43 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.18619890 |
| 44 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.13855289 |
| 45 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.13796011 |
| 46 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.13667466 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.12886725 |
| 48 | Taste transduction_Homo sapiens_hsa04742 | 1.12833510 |
| 49 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.09486214 |
| 50 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.07534381 |
| 51 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.06498457 |
| 52 | Salivary secretion_Homo sapiens_hsa04970 | 1.05436921 |
| 53 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.03657531 |
| 54 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.01951271 |
| 55 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.00193348 |
| 56 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.98113219 |
| 57 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.97610514 |
| 58 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.97575778 |
| 59 | Melanoma_Homo sapiens_hsa05218 | 0.96429886 |
| 60 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.96242500 |
| 61 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.96071027 |
| 62 | Tight junction_Homo sapiens_hsa04530 | 0.95632204 |
| 63 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.95416894 |
| 64 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.93859130 |
| 65 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.92953211 |
| 66 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.91965401 |
| 67 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.90246513 |
| 68 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.90206405 |
| 69 | Viral myocarditis_Homo sapiens_hsa05416 | 0.90180570 |
| 70 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.89721912 |
| 71 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.88287008 |
| 72 | Pathways in cancer_Homo sapiens_hsa05200 | 0.88225963 |
| 73 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.87413681 |
| 74 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.86810872 |
| 75 | Prostate cancer_Homo sapiens_hsa05215 | 0.85430043 |
| 76 | Amoebiasis_Homo sapiens_hsa05146 | 0.83969450 |
| 77 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.83937002 |
| 78 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.83451522 |
| 79 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.82810910 |
| 80 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.81133745 |
| 81 | Lysine degradation_Homo sapiens_hsa00310 | 0.80599018 |
| 82 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.79645305 |
| 83 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.79306335 |
| 84 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.79148514 |
| 85 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.79077181 |
| 86 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.78666169 |
| 87 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.78454110 |
| 88 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.77714807 |
| 89 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.76849126 |
| 90 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.75125690 |
| 91 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.72963283 |
| 92 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.71119020 |
| 93 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.70095548 |
| 94 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.68991928 |
| 95 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.68678936 |
| 96 | Bladder cancer_Homo sapiens_hsa05219 | 0.66719361 |
| 97 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.66458775 |
| 98 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.65948618 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.65506639 |
| 100 | Platelet activation_Homo sapiens_hsa04611 | 0.64136893 |
| 101 | HTLV-I infection_Homo sapiens_hsa05166 | 0.63830221 |
| 102 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.63339100 |
| 103 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.62511849 |
| 104 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.61927271 |
| 105 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.60948161 |
| 106 | Thyroid cancer_Homo sapiens_hsa05216 | 0.60756939 |
| 107 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.56193310 |
| 108 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.55990089 |
| 109 | Circadian rhythm_Homo sapiens_hsa04710 | 0.54081432 |
| 110 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.51039496 |
| 111 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.48177764 |
| 112 | Prion diseases_Homo sapiens_hsa05020 | 0.46782026 |

