KIF27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the KIF27 (kinesin 4) sub-family of the mammalian kinesin family. The gene is an ortholog of the Drosophila Cos2 gene, which plays an important role in the Hedgehog signaling pathway. The encoded protein contains an N-terminal motor domain which includes nucleotide-binding and microtubule-interacting regions, a stalk domain containing a predicted coiled coil motif and a C-terminal tail domain. Alternatively spliced transcript variants have been observed for this gene. Pseudogenes associated with this gene are located on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.72958484
2cell-cell recognition (GO:0009988)9.63514222
3* epithelial cilium movement (GO:0003351)9.51015534
4motile cilium assembly (GO:0044458)9.39927685
5reproduction (GO:0000003)9.00839972
6spermatid development (GO:0007286)9.00667130
7* cilium movement (GO:0003341)8.87043646
8piRNA metabolic process (GO:0034587)8.82347853
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.55670578
10regulation of cilium movement (GO:0003352)8.42058967
11male meiosis (GO:0007140)8.15414543
12synaptonemal complex organization (GO:0070193)7.67761116
13synaptonemal complex assembly (GO:0007130)7.41097101
14single fertilization (GO:0007338)7.31483311
15sperm capacitation (GO:0048240)6.79955637
16fertilization (GO:0009566)6.26438951
17spermatogenesis (GO:0007283)6.07744445
18male gamete generation (GO:0048232)6.05692824
19negative regulation of inclusion body assembly (GO:0090084)6.03065168
20DNA methylation involved in gamete generation (GO:0043046)5.79633291
21microtubule depolymerization (GO:0007019)5.72036434
22gamete generation (GO:0007276)5.57858441
23male meiosis I (GO:0007141)5.54906536
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.21494932
25germ cell development (GO:0007281)5.20443896
26organic cation transport (GO:0015695)5.18276719
27microtubule severing (GO:0051013)5.14619269
28chromosome organization involved in meiosis (GO:0070192)5.13814656
29calcium ion-dependent exocytosis (GO:0017156)5.07388396
30regulation of inclusion body assembly (GO:0090083)5.03867515
31regulation of microtubule-based movement (GO:0060632)5.00230507
32cell recognition (GO:0008037)4.82057161
33meiotic nuclear division (GO:0007126)4.79690036
34* ventricular system development (GO:0021591)4.47741825
35left/right pattern formation (GO:0060972)4.47418226
36spermatid nucleus differentiation (GO:0007289)4.42725504
37meiosis I (GO:0007127)4.41466713
38multicellular organismal reproductive process (GO:0048609)4.40627989
39seminiferous tubule development (GO:0072520)4.32011207
40neural tube formation (GO:0001841)4.30528055
41protein localization to cilium (GO:0061512)4.28393411
42axoneme assembly (GO:0035082)4.12822435
43protein polyglutamylation (GO:0018095)4.02452422
44intraciliary transport (GO:0042073)4.01819581
45monoubiquitinated protein deubiquitination (GO:0035520)4.01157130
46meiotic cell cycle (GO:0051321)3.96747253
47behavioral response to nicotine (GO:0035095)3.92023154
48nonmotile primary cilium assembly (GO:0035058)3.86154871
49genitalia morphogenesis (GO:0035112)3.85825011
50establishment of protein localization to Golgi (GO:0072600)3.74851580
51glycerol ether metabolic process (GO:0006662)3.68064772
52chromosome condensation (GO:0030261)3.53589641
53multicellular organismal development (GO:0007275)3.50144259
54photoreceptor cell maintenance (GO:0045494)3.49498455
55protein targeting to Golgi (GO:0000042)3.47318325
56microtubule bundle formation (GO:0001578)3.46282782
57DNA packaging (GO:0006323)3.42932871
58* microtubule-based movement (GO:0007018)3.40856891
59ether metabolic process (GO:0018904)3.39495092
60* cilium organization (GO:0044782)3.39221565
61chaperone-mediated protein complex assembly (GO:0051131)3.39089298
62* smoothened signaling pathway (GO:0007224)3.36832515
63nucleoside diphosphate phosphorylation (GO:0006165)3.35141099
64cilium morphogenesis (GO:0060271)3.30958613
65gene silencing by RNA (GO:0031047)3.30604877
66protein K11-linked deubiquitination (GO:0035871)3.23701724
67* cilium assembly (GO:0042384)3.21772738
68L-fucose catabolic process (GO:0042355)3.18266916
69fucose catabolic process (GO:0019317)3.18266916
70L-fucose metabolic process (GO:0042354)3.18266916
71determination of left/right symmetry (GO:0007368)3.17688012
72cornea development in camera-type eye (GO:0061303)3.16390234
73* cell projection assembly (GO:0030031)3.15454884
74retrograde transport, vesicle recycling within Golgi (GO:0000301)3.14336186
75negative regulation of organelle assembly (GO:1902116)3.14090058
76regulation of meiosis I (GO:0060631)3.11328359
77meiotic cell cycle process (GO:1903046)3.11086142
78centriole assembly (GO:0098534)3.09088290
79* cellular component assembly involved in morphogenesis (GO:0010927)3.08637804
80GTP biosynthetic process (GO:0006183)3.06970610
81single strand break repair (GO:0000012)3.02199197
82synapsis (GO:0007129)3.01480065
83determination of bilateral symmetry (GO:0009855)3.01105897
84protein refolding (GO:0042026)3.00450116
85negative regulation of translation, ncRNA-mediated (GO:0040033)2.96897352
86regulation of translation, ncRNA-mediated (GO:0045974)2.96897352
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96897352
88protein localization to Golgi apparatus (GO:0034067)2.96327531
89response to pheromone (GO:0019236)2.94342504
90microtubule polymerization or depolymerization (GO:0031109)2.94049114
91specification of symmetry (GO:0009799)2.93876392
92regulation of DNA endoreduplication (GO:0032875)2.93117465
93negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92636057
94lactate metabolic process (GO:0006089)2.92556159
95regulation of centriole replication (GO:0046599)2.90076538
96regulation of spindle checkpoint (GO:0090231)2.89263294
97centriole replication (GO:0007099)2.87648486
98left/right axis specification (GO:0070986)2.83202542
99polyol catabolic process (GO:0046174)2.81265869
100amino-acid betaine transport (GO:0015838)2.81231909
101carnitine transport (GO:0015879)2.81231909
102mitotic sister chromatid cohesion (GO:0007064)2.80692647
103nuclear pore complex assembly (GO:0051292)2.79758057
104somite development (GO:0061053)2.78486208
105nucleus organization (GO:0006997)2.78473041
106retinal cone cell development (GO:0046549)2.78211878
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.77054625
108substrate-independent telencephalic tangential migration (GO:0021826)2.77054625
109limb bud formation (GO:0060174)2.76493344
110olfactory bulb development (GO:0021772)2.75975297
111glycolytic process (GO:0006096)2.75617959
112regulation of collateral sprouting (GO:0048670)2.72726371
113UTP biosynthetic process (GO:0006228)2.72661746
114carnitine transmembrane transport (GO:1902603)2.71838905
115limb development (GO:0060173)2.68971198
116appendage development (GO:0048736)2.68971198
117sexual reproduction (GO:0019953)2.65567088
118regulation of telomere maintenance (GO:0032204)2.65240253
119alditol metabolic process (GO:0019400)2.63693845
120retinal rod cell development (GO:0046548)2.61671007
121regulation of protein polyubiquitination (GO:1902914)2.55944734
122detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55504017
123* organelle assembly (GO:0070925)2.54739843
124reciprocal DNA recombination (GO:0035825)2.54640439
125reciprocal meiotic recombination (GO:0007131)2.54640439
126indole-containing compound catabolic process (GO:0042436)2.52519922
127indolalkylamine catabolic process (GO:0046218)2.52519922
128tryptophan catabolic process (GO:0006569)2.52519922
129photoreceptor cell development (GO:0042461)2.52070584
130gene silencing (GO:0016458)2.51293126
131DNA double-strand break processing (GO:0000729)2.51056906
132indolalkylamine metabolic process (GO:0006586)2.50575861
133peptidyl-glutamic acid modification (GO:0018200)2.50119110
134platelet dense granule organization (GO:0060155)2.47530526
135presynaptic membrane organization (GO:0097090)2.45976453
136lateral ventricle development (GO:0021670)2.45640561
137sequestering of actin monomers (GO:0042989)2.44698563
138spinal cord motor neuron differentiation (GO:0021522)2.43759176
139retinal ganglion cell axon guidance (GO:0031290)2.43249367
140transmission of nerve impulse (GO:0019226)2.42453396
141histone H3-K9 methylation (GO:0051567)2.42376217
142hindbrain development (GO:0030902)2.41905154
143central nervous system neuron axonogenesis (GO:0021955)2.37846071
144replication fork processing (GO:0031297)2.37569687
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36595720
146cell proliferation in forebrain (GO:0021846)2.36408923
147embryonic epithelial tube formation (GO:0001838)2.34771805
148behavioral response to ethanol (GO:0048149)2.34200020
149eye photoreceptor cell development (GO:0042462)2.30847280
150cilium or flagellum-dependent cell motility (GO:0001539)13.2430254
151fusion of sperm to egg plasma membrane (GO:0007342)13.2353153
152sperm motility (GO:0030317)12.4780901
153axonemal dynein complex assembly (GO:0070286)11.3134966
154acrosome assembly (GO:0001675)10.9139240
155cell wall macromolecule catabolic process (GO:0016998)10.8396550
156cell wall macromolecule metabolic process (GO:0044036)10.8396550
157multicellular organism reproduction (GO:0032504)10.8234651
158sperm-egg recognition (GO:0035036)10.7945179
159acrosome reaction (GO:0007340)10.5996571
160plasma membrane fusion (GO:0045026)10.1186184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.14969597
2EZH2_22144423_ChIP-Seq_EOC_Human5.19667971
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.56414942
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.71233819
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33334789
6IGF1R_20145208_ChIP-Seq_DFB_Human3.15468236
7GBX2_23144817_ChIP-Seq_PC3_Human3.12376515
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98880237
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.73862680
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.56942448
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.42492774
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34010912
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.28068627
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.24702940
15P300_19829295_ChIP-Seq_ESCs_Human2.23461636
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16407268
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15439648
18ZNF274_21170338_ChIP-Seq_K562_Hela2.10165605
19EWS_26573619_Chip-Seq_HEK293_Human2.06564161
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04366998
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.02206972
22* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.00989077
23VDR_22108803_ChIP-Seq_LS180_Human1.96525103
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90003423
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89715745
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.87832539
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.85585155
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82418459
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82029156
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77993602
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.76939645
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75805286
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73390541
34STAT3_23295773_ChIP-Seq_U87_Human1.72237732
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70778485
36TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.69192964
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.67634415
38AR_21572438_ChIP-Seq_LNCaP_Human1.66300727
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65562372
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64292231
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.61886352
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57390707
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56351348
44AR_25329375_ChIP-Seq_VCAP_Human1.55798758
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55567924
46BCAT_22108803_ChIP-Seq_LS180_Human1.51605371
47STAT1_17558387_ChIP-Seq_HELA_Human1.51536113
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50340603
49TAL1_26923725_Chip-Seq_HPCs_Mouse1.49807490
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.49647406
51REST_21632747_ChIP-Seq_MESCs_Mouse1.46502426
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46416773
53KDM2B_26808549_Chip-Seq_REH_Human1.45607571
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.44880529
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44530551
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43715661
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42397916
58KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40892759
59IRF1_19129219_ChIP-ChIP_H3396_Human1.40050554
60RUNX2_22187159_ChIP-Seq_PCA_Human1.39988101
61* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37019107
62* CBP_20019798_ChIP-Seq_JUKART_Human1.37019107
63RNF2_27304074_Chip-Seq_NSC_Mouse1.36766061
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36584438
65TCF4_22108803_ChIP-Seq_LS180_Human1.35051294
66FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34469488
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.34390946
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.33337346
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31673901
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30280652
71TP53_22573176_ChIP-Seq_HFKS_Human1.30274354
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.28234796
73AHR_22903824_ChIP-Seq_MCF-7_Human1.27597578
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26817556
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26685442
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24511176
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24296618
78SOX2_19829295_ChIP-Seq_ESCs_Human1.23718559
79NANOG_19829295_ChIP-Seq_ESCs_Human1.23718559
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22334206
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19818514
82P53_22387025_ChIP-Seq_ESCs_Mouse1.19648984
83TAF15_26573619_Chip-Seq_HEK293_Human1.19380065
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19166066
85CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18255514
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.18095333
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17846160
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17575393
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16241459
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.15413975
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.15333651
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15040834
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.14792124
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14109584
95GF1_26923725_Chip-Seq_HPCs_Mouse1.14100527
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13929944
97LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.13713833
98GATA3_21867929_ChIP-Seq_TH1_Mouse1.12454609
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.12025817
100* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11768029
101* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11768029
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11664371
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10787479
104P300_18555785_Chip-Seq_ESCs_Mouse1.09915759
105HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09910687
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.09508727
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09457836
108SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08458380
109CDX2_22108803_ChIP-Seq_LS180_Human1.08026666
110P53_21459846_ChIP-Seq_SAOS-2_Human1.06677031
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05531498
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04654007
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04592062
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.03719571
115NCOR_22424771_ChIP-Seq_293T_Human1.03192508
116OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03122124
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01957451
118SOX2_21211035_ChIP-Seq_LN229_Gbm1.01848905
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01799002
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01601446
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01371654
122STAT3_18555785_Chip-Seq_ESCs_Mouse1.01030801
123TCF4_23295773_ChIP-Seq_U87_Human1.00706313
124RXR_22108803_ChIP-Seq_LS180_Human1.00696337
125FUS_26573619_Chip-Seq_HEK293_Human1.00418566
126RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00315106
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00207545
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99615643
129SOX9_26525672_Chip-Seq_HEART_Mouse0.99533291
130* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99200096
131TP53_16413492_ChIP-PET_HCT116_Human0.98989064
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98798918
133FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97523981
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.97523981
135FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97061996
136E2F1_18555785_Chip-Seq_ESCs_Mouse0.96975154
137SMAD4_21799915_ChIP-Seq_A2780_Human0.96574453
138TBL1_22424771_ChIP-Seq_293T_Human0.95224754
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.93686037
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93590132
141* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93115067
142* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92600103
143* SMAD4_21741376_ChIP-Seq_EPCs_Human0.91640907
144GF1B_26923725_Chip-Seq_HPCs_Mouse0.91637473
145ERG_20517297_ChIP-Seq_VCAP_Human0.91627821
146NFYB_21822215_ChIP-Seq_K562_Human0.90833192
147PU1_27457419_Chip-Seq_LIVER_Mouse0.90705820
148CTCF_18555785_Chip-Seq_ESCs_Mouse0.88949934
149EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88482594
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88311362
151ER_23166858_ChIP-Seq_MCF-7_Human0.87739625
152RUNX1_27457419_Chip-Seq_LIVER_Mouse0.87342571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.91680894
2MP0001929_abnormal_gametogenesis5.38625564
3MP0008877_abnormal_DNA_methylation5.01262682
4MP0002210_abnormal_sex_determination3.65993204
5MP0006292_abnormal_olfactory_placode3.63367034
6MP0002653_abnormal_ependyma_morphology3.44015437
7MP0002161_abnormal_fertility/fecundity3.22287870
8MP0001145_abnormal_male_reproductive3.08449073
9MP0000653_abnormal_sex_gland2.71403616
10MP0002638_abnormal_pupillary_reflex2.42898706
11MP0005623_abnormal_meninges_morphology2.40555074
12MP0008789_abnormal_olfactory_epithelium2.34823592
13MP0001485_abnormal_pinna_reflex2.09037878
14MP0005670_abnormal_white_adipose2.06699558
15MP0005410_abnormal_fertilization14.8575891
16MP0005499_abnormal_olfactory_system1.99800302
17MP0005394_taste/olfaction_phenotype1.99800302
18MP0002160_abnormal_reproductive_system1.97968734
19MP0000631_abnormal_neuroendocrine_gland1.75752502
20MP0003121_genomic_imprinting1.71152628
21MP0002282_abnormal_trachea_morphology1.60006319
22MP0001984_abnormal_olfaction1.56356482
23MP0006276_abnormal_autonomic_nervous1.55469728
24MP0004043_abnormal_pH_regulation1.52533121
25MP0001529_abnormal_vocalization1.49840501
26MP0008995_early_reproductive_senescence1.47217456
27MP0004885_abnormal_endolymph1.46318921
28MP0009046_muscle_twitch1.38840735
29MP0003646_muscle_fatigue1.38371869
30MP0003195_calcinosis1.34574940
31MP0008057_abnormal_DNA_replication1.33792656
32MP0005084_abnormal_gallbladder_morpholo1.32650371
33MP0000383_abnormal_hair_follicle1.29570000
34MP0002938_white_spotting1.28039304
35MP0004142_abnormal_muscle_tone1.25271164
36MP0003122_maternal_imprinting1.25266337
37MP0008058_abnormal_DNA_repair1.19486567
38MP0008875_abnormal_xenobiotic_pharmacok1.19311605
39MP0005248_abnormal_Harderian_gland1.17955331
40MP0004233_abnormal_muscle_weight1.14442732
41MP0001188_hyperpigmentation1.14121715
42MP0003890_abnormal_embryonic-extraembry1.10789357
43MP0002876_abnormal_thyroid_physiology1.09319004
44MP0005647_abnormal_sex_gland1.08513422
45MP0000026_abnormal_inner_ear1.05531042
46MP0001765_abnormal_ion_homeostasis1.03665085
47MP0000569_abnormal_digit_pigmentation1.01891129
48MP0005389_reproductive_system_phenotype1.01355092
49MP0005645_abnormal_hypothalamus_physiol0.99456121
50MP0002233_abnormal_nose_morphology0.98154948
51MP0008872_abnormal_physiological_respon0.95455946
52MP0002277_abnormal_respiratory_mucosa0.95014010
53MP0005377_hearing/vestibular/ear_phenot0.93826497
54MP0003878_abnormal_ear_physiology0.93826497
55MP0002184_abnormal_innervation0.93360314
56MP0000372_irregular_coat_pigmentation0.92753798
57MP0002102_abnormal_ear_morphology0.91550189
58MP0002735_abnormal_chemical_nociception0.91257373
59MP0005174_abnormal_tail_pigmentation0.90930483
60MP0003718_maternal_effect0.90563089
61MP0000049_abnormal_middle_ear0.87015924
62MP0001986_abnormal_taste_sensitivity0.86624735
63MP0001963_abnormal_hearing_physiology0.86231816
64MP0002751_abnormal_autonomic_nervous0.86055079
65MP0002067_abnormal_sensory_capabilities0.85713693
66MP0003937_abnormal_limbs/digits/tail_de0.85290971
67MP0001919_abnormal_reproductive_system0.83075606
68MP0002132_abnormal_respiratory_system0.80392617
69MP0003115_abnormal_respiratory_system0.79004996
70MP0010094_abnormal_chromosome_stability0.77527180
71MP0002909_abnormal_adrenal_gland0.77502735
72MP0003938_abnormal_ear_development0.77035028
73MP0003787_abnormal_imprinting0.75023398
74MP0001501_abnormal_sleep_pattern0.74924863
75MP0005083_abnormal_biliary_tract0.74914538
76MP0002928_abnormal_bile_duct0.74551855
77MP0001286_abnormal_eye_development0.73629438
78MP0010386_abnormal_urinary_bladder0.72268626
79MP0002064_seizures0.70701640
80MP0002234_abnormal_pharynx_morphology0.70255540
81MP0003950_abnormal_plasma_membrane0.70127280
82MP0010678_abnormal_skin_adnexa0.69844858
83MP0005171_absent_coat_pigmentation0.68232425
84MP0003786_premature_aging0.63565822
85MP0005551_abnormal_eye_electrophysiolog0.63091637
86MP0001293_anophthalmia0.61225409
87MP0004270_analgesia0.56015117
88MP0003699_abnormal_female_reproductive0.55673993
89MP0004133_heterotaxia0.52730061
90MP0004859_abnormal_synaptic_plasticity0.50705919
91MP0005253_abnormal_eye_physiology0.49081717
92MP0003861_abnormal_nervous_system0.48963970
93MP0003942_abnormal_urinary_system0.48861831
94MP0003879_abnormal_hair_cell0.48468523
95MP0001324_abnormal_eye_pigmentation0.47255533
96MP0002152_abnormal_brain_morphology0.47022887
97MP0001119_abnormal_female_reproductive0.46963120
98MP0002063_abnormal_learning/memory/cond0.46425836
99MP0002572_abnormal_emotion/affect_behav0.45620016
100MP0000358_abnormal_cell_content/0.45516008
101MP0003635_abnormal_synaptic_transmissio0.45252761
102MP0004811_abnormal_neuron_physiology0.44833543
103MP0004742_abnormal_vestibular_system0.44724643
104MP0002736_abnormal_nociception_after0.42184125
105MP0005391_vision/eye_phenotype0.40952791
106MP0000534_abnormal_ureter_morphology0.40105194
107MP0001440_abnormal_grooming_behavior0.39611839
108MP0009115_abnormal_fat_cell0.37942424
109MP0005666_abnormal_adipose_tissue0.37542556
110MP0003011_delayed_dark_adaptation0.36483087
111MP0005636_abnormal_mineral_homeostasis0.36111084
112MP0001486_abnormal_startle_reflex0.35923413
113MP0003633_abnormal_nervous_system0.35338215
114MP0002557_abnormal_social/conspecific_i0.35240438
115MP0009745_abnormal_behavioral_response0.34730269
116MP0003111_abnormal_nucleus_morphology0.34304176
117MP0000778_abnormal_nervous_system0.33999733
118MP0001968_abnormal_touch/_nociception0.33609434
119MP0003329_amyloid_beta_deposits0.33390743
120MP0008007_abnormal_cellular_replicative0.33374141
121MP0003136_yellow_coat_color0.33079874
122MP0005423_abnormal_somatic_nervous0.32726435
123MP0004134_abnormal_chest_morphology0.31969863
124MP0004036_abnormal_muscle_relaxation0.31542176
125MP0002272_abnormal_nervous_system0.29462567
126MP0005397_hematopoietic_system_phenotyp0.29182869
127MP0001545_abnormal_hematopoietic_system0.29182869
128MP0003631_nervous_system_phenotype0.29001868
129MP0002084_abnormal_developmental_patter0.28960158
130MP0005646_abnormal_pituitary_gland0.28248320
131MP0002108_abnormal_muscle_morphology0.28245460
132MP0006072_abnormal_retinal_apoptosis0.28238903
133MP0003880_abnormal_central_pattern0.26531831
134MP0002092_abnormal_eye_morphology0.26528595
135MP0002882_abnormal_neuron_morphology0.26420143
136MP0010307_abnormal_tumor_latency0.26341058
137MP0003123_paternal_imprinting0.25813442
138MP0002971_abnormal_brown_adipose0.25410868
139MP0005195_abnormal_posterior_eye0.25360170
140MP0000955_abnormal_spinal_cord0.24900011
141MP0002229_neurodegeneration0.24743390
142MP0002269_muscular_atrophy0.24730227
143MP0000427_abnormal_hair_cycle0.24615941
144MP0002822_catalepsy0.23802998
145MP0002752_abnormal_somatic_nervous0.23361603
146MP0003045_fibrosis0.23254005
147MP0003948_abnormal_gas_homeostasis0.23098916
148MP0001730_embryonic_growth_arrest0.23031042
149MP0002133_abnormal_respiratory_system0.22229957
150MP0005388_respiratory_system_phenotype0.22229957

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.89912287
2Abnormal respiratory motile cilium morphology (HP:0005938)9.06567356
3Abnormal respiratory epithelium morphology (HP:0012253)9.06567356
4Abnormal ciliary motility (HP:0012262)8.40433020
5Rhinitis (HP:0012384)8.04224960
6Chronic bronchitis (HP:0004469)7.08766202
7Infertility (HP:0000789)6.17139701
8Nasal polyposis (HP:0100582)6.00980383
9Abnormality of the nasal mucosa (HP:0000433)4.91693540
10Bronchiectasis (HP:0002110)4.71795208
11Nephronophthisis (HP:0000090)4.40500000
12Bronchitis (HP:0012387)4.30235122
13Male infertility (HP:0003251)4.17900319
14Abnormality of the renal medulla (HP:0100957)3.39669680
15Recurrent sinusitis (HP:0011108)3.25939978
16Tubulointerstitial nephritis (HP:0001970)3.19293096
17Abnormal spermatogenesis (HP:0008669)3.16235004
18Recurrent otitis media (HP:0000403)3.13557258
19Anencephaly (HP:0002323)2.92969538
20Molar tooth sign on MRI (HP:0002419)2.87309897
21Abnormality of midbrain morphology (HP:0002418)2.87309897
22Medial flaring of the eyebrow (HP:0010747)2.68509847
23Sclerocornea (HP:0000647)2.68175960
24Tubular atrophy (HP:0000092)2.56336394
25Tubulointerstitial abnormality (HP:0001969)2.54296033
26Abnormality of the lower motor neuron (HP:0002366)2.51234676
27Recurrent bronchitis (HP:0002837)2.44547736
28Abnormal rod and cone electroretinograms (HP:0008323)2.41779443
29Gonadotropin excess (HP:0000837)2.40697649
30Azoospermia (HP:0000027)2.36818867
31Progressive cerebellar ataxia (HP:0002073)2.33466796
32Furrowed tongue (HP:0000221)2.30194680
33Postaxial foot polydactyly (HP:0001830)2.29881911
34Fibular hypoplasia (HP:0003038)2.29010982
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22220192
36Impulsivity (HP:0100710)2.20872330
37Hyperventilation (HP:0002883)2.19387067
38Preaxial hand polydactyly (HP:0001177)2.08292272
39Congenital stationary night blindness (HP:0007642)2.06519053
40Pancreatic fibrosis (HP:0100732)2.04427507
41Congenital hepatic fibrosis (HP:0002612)2.02421728
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2462156
43Absent/shortened dynein arms (HP:0200106)12.4524143
44Dynein arm defect of respiratory motile cilia (HP:0012255)12.4524143
45Stage 5 chronic kidney disease (HP:0003774)1.97295874
46Amyotrophic lateral sclerosis (HP:0007354)1.95883082
47Tubulointerstitial fibrosis (HP:0005576)1.93891694
48Attenuation of retinal blood vessels (HP:0007843)1.91718019
49Type II lissencephaly (HP:0007260)1.90559757
50Absent speech (HP:0001344)1.86730891
51Polyuria (HP:0000103)1.85744926
52Chronic otitis media (HP:0000389)1.83275960
53Supernumerary spleens (HP:0009799)1.82776524
54Narrow forehead (HP:0000341)1.82438540
55Chronic sinusitis (HP:0011109)1.82279114
56Bony spicule pigmentary retinopathy (HP:0007737)1.82082590
57True hermaphroditism (HP:0010459)1.81657475
58Facial cleft (HP:0002006)1.80556329
59Cystic liver disease (HP:0006706)1.80250357
60Optic nerve hypoplasia (HP:0000609)1.79856707
61Oculomotor apraxia (HP:0000657)1.79598480
62Short ribs (HP:0000773)1.78607314
63Abnormal biliary tract physiology (HP:0012439)1.76495204
64Bile duct proliferation (HP:0001408)1.76495204
65Abnormality of macular pigmentation (HP:0008002)1.76406639
66Postaxial hand polydactyly (HP:0001162)1.75403803
67Abnormality of the renal cortex (HP:0011035)1.74705418
68Abnormality of dentin (HP:0010299)1.73943530
69Abnormality of permanent molar morphology (HP:0011071)1.73847775
70Abnormality of the dental root (HP:0006486)1.73847775
71Taurodontia (HP:0000679)1.73847775
72Aganglionic megacolon (HP:0002251)1.73340797
73Prominent nasal bridge (HP:0000426)1.72394422
74Polydipsia (HP:0001959)1.72111707
75Abnormal drinking behavior (HP:0030082)1.72111707
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.70106728
77Gait imbalance (HP:0002141)1.70043065
78Congenital primary aphakia (HP:0007707)1.68413914
79Median cleft lip (HP:0000161)1.68250862
80Microglossia (HP:0000171)1.68228646
81Retinitis pigmentosa (HP:0000510)1.68118498
82Gaze-evoked nystagmus (HP:0000640)1.67249353
83Oligodactyly (hands) (HP:0001180)1.66808290
84Abolished electroretinogram (ERG) (HP:0000550)1.65020641
85Cerebellar dysplasia (HP:0007033)1.64950247
86Heterotopia (HP:0002282)1.63719241
87Highly arched eyebrow (HP:0002553)1.63602871
88Hip dysplasia (HP:0001385)1.63346794
89Bell-shaped thorax (HP:0001591)1.63270322
90Astigmatism (HP:0000483)1.63259894
91Abnormality of molar (HP:0011077)1.62886216
92Abnormality of molar morphology (HP:0011070)1.62886216
93Aplasia/Hypoplasia of the uvula (HP:0010293)1.62628710
94Multicystic kidney dysplasia (HP:0000003)1.61138584
95Renal cortical cysts (HP:0000803)1.60849869
96Abnormality of the dental pulp (HP:0006479)1.58012208
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.57419215
98Sloping forehead (HP:0000340)1.56719985
99Absent frontal sinuses (HP:0002688)1.56665378
100Dandy-Walker malformation (HP:0001305)1.56521232
101Dyschromatopsia (HP:0007641)1.55489619
102Anophthalmia (HP:0000528)1.55449755
103Renal dysplasia (HP:0000110)1.54407593
104Spastic tetraparesis (HP:0001285)1.53679469
105Hypoplasia of the capital femoral epiphysis (HP:0003090)1.52956423
106Abnormality of renal excretion (HP:0011036)1.52626344
107Decreased central vision (HP:0007663)1.49628884
108Lissencephaly (HP:0001339)1.49086990
109Aplasia/Hypoplasia of the fibula (HP:0006492)1.47913425
110Specific learning disability (HP:0001328)1.47291896
111Optic nerve coloboma (HP:0000588)1.45876811
112Broad-based gait (HP:0002136)1.45875674
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.45073111
114Hypoplasia of the fovea (HP:0007750)1.45073111
115Broad foot (HP:0001769)1.44921861
116Chronic hepatic failure (HP:0100626)1.43502030
117Genetic anticipation (HP:0003743)1.43462804
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.42983922
119Nephrogenic diabetes insipidus (HP:0009806)1.42691023
120Febrile seizures (HP:0002373)1.42490044
121Ectopic kidney (HP:0000086)1.41819977
122Abnormal gallbladder physiology (HP:0012438)1.41392625
123Cholecystitis (HP:0001082)1.41392625
124Choroideremia (HP:0001139)1.41253935
125Protruding tongue (HP:0010808)1.41119479
126Occipital encephalocele (HP:0002085)1.40765017
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40047634
128Aplasia/Hypoplasia of the lens (HP:0008063)1.39074065
129Short thorax (HP:0010306)1.37561305
130Impaired proprioception (HP:0010831)1.37465501
131Pancreatic cysts (HP:0001737)1.37180990
132Genital tract atresia (HP:0001827)1.35173247
133J-shaped sella turcica (HP:0002680)1.35154418
134Broad distal phalanx of finger (HP:0009836)1.33885680
135Poor coordination (HP:0002370)1.32613241
136Vaginal atresia (HP:0000148)1.29241071
137Nephropathy (HP:0000112)1.26612211
138Abnormality of ocular smooth pursuit (HP:0000617)1.26604711
139Absent epiphyses (HP:0010577)1.23182945
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23182945
141Pachygyria (HP:0001302)1.20273147
142Abnormal urine output (HP:0012590)1.19541218
143Neurofibrillary tangles (HP:0002185)1.19279454
144Deformed sella turcica (HP:0002681)1.15704716
145Male pseudohermaphroditism (HP:0000037)1.14317260
146Truncal obesity (HP:0001956)1.11636217
147Nephroblastoma (Wilms tumor) (HP:0002667)1.11351085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.53051998
2PDK38.53051998
3PDK25.45637226
4TESK14.88634270
5PRKD34.73072964
6FRK4.11039832
7ICK3.57084475
8ZAK3.09855424
9PNCK2.94653432
10PTK2B2.48922068
11WNK42.13037912
12STK392.03688514
13MAP4K22.01760555
14NUAK12.00781626
15MAPK131.91602627
16BMPR1B1.90078652
17TAOK31.89696186
18INSRR1.84589062
19ADRBK21.79186883
20TNIK1.77153650
21STK381.60191329
22NEK21.58535675
23GRK11.39863314
24BCR1.35978383
25OXSR11.25842304
26MAPK151.25600236
27TRIM281.21358769
28CASK1.15426692
29TLK11.13464554
30TXK1.13128520
31DYRK1B1.09313295
32VRK11.08673347
33PAK31.04102494
34WNK11.04043435
35MST41.03222061
36TYRO31.02968588
37SGK20.99963413
38CAMKK20.98671881
39PDK10.97598955
40ACVR1B0.95021799
41MKNK20.93215560
42CSNK1A1L0.93166008
43CSNK1G20.92712909
44TIE10.90284187
45CSNK1G10.87532655
46ERBB30.87250422
47STK38L0.85978300
48CSNK1G30.85539810
49SGK4940.84248494
50SGK2230.84248494
51CAMK1G0.80029661
52STK30.79602958
53GRK70.79080870
54TNK20.76860999
55CDC70.75962692
56PIK3CA0.75484224
57BCKDK0.75424687
58IRAK10.74834087
59PRKCE0.74574508
60LMTK20.74377416
61PIK3CG0.73843666
62DYRK30.73680640
63TTK0.73144253
64OBSCN0.72977603
65AKT30.72674895
66BRD40.71931714
67DYRK20.70178232
68PASK0.69117063
69RPS6KA50.63414051
70CHEK20.60145632
71CCNB10.59956375
72WEE10.57290454
73ADRBK10.56947534
74FGFR20.56934726
75MAP2K40.55187008
76MAP3K40.55066365
77PLK30.54957737
78MKNK10.54807455
79PLK40.53702156
80CHEK10.53444011
81RIPK40.53208626
82NTRK20.51164419
83CAMK40.50574736
84CAMK10.50394300
85CDK190.49381012
86PDPK10.48653827
87NLK0.48439273
88EIF2AK30.48041923
89DYRK1A0.46743989
90CDK120.46065504
91EEF2K0.43094391
92TEC0.42833003
93PRKCG0.42458441
94TGFBR10.41495113
95SGK10.40066811
96PKN10.39403891
97PINK10.39239631
98ERBB20.38305493
99ATM0.37366808
100MAP2K60.34941771
101CHUK0.34706891
102KIT0.33783209
103ATR0.33673716
104CAMKK10.33380989
105EPHA40.32697029
106NEK60.32669454
107MTOR0.32574082
108PAK10.32500452
109IRAK20.31058055
110CSNK1A10.30887441
111MAP2K70.28606917
112PLK10.26980906
113MUSK0.26517020
114MARK10.23011216
115PRKAA10.22570673
116PAK20.21427054
117RPS6KB10.20931855
118PRKCZ0.19135857
119MINK10.17414135
120NTRK30.16970661
121STK110.16928242
122MARK20.16022816
123PAK60.15110970
124GSK3B0.13740878
125CAMK2A0.13239895
126CSNK1D0.12097285
127LATS10.12070667
128WNK30.11918724
129CDK10.11487626
130BRSK20.10786416
131BRAF0.10175003
132CDK30.09115032
133CDK20.09037780
134MAPK80.08967885
135CDK150.08524096
136PRKDC0.08030932
137RPS6KA10.07762149
138MAPK100.07531410
139PRKG10.07419559
140CDK180.07298332
141PRKACG0.06943750
142RPS6KA30.06801752
143BRSK10.06628612
144PLK20.06397379
145PRKCB0.05759966
146PRKCQ0.05245092
147CDK140.04287301
148CDK50.04204128
149CDK11A0.04018248
150MAPKAPK50.03050027
151CSNK1E0.02885157
152PAK40.02370160
153CSNK2A10.01847772
154CSNK2A20.01472609
155PRKACA0.01351306
156MARK30.00997352
157PDGFRB0.00752410
158TESK20.00678723
159AURKA0.00498743
160RIPK10.00259473
161CDK40.00194306
162PRKCA-0.0022054

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.71219804
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.70851465
3Fatty acid biosynthesis_Homo sapiens_hsa000613.69513301
4Pyruvate metabolism_Homo sapiens_hsa006203.41844060
5Glucagon signaling pathway_Homo sapiens_hsa049222.71362987
6Propanoate metabolism_Homo sapiens_hsa006402.50764551
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50627960
8Dorso-ventral axis formation_Homo sapiens_hsa043202.49316690
9Nitrogen metabolism_Homo sapiens_hsa009102.36617034
10Basal transcription factors_Homo sapiens_hsa030222.36613551
11Oocyte meiosis_Homo sapiens_hsa041142.31415154
12Butanoate metabolism_Homo sapiens_hsa006502.27964587
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24106598
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19620527
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14905175
16Linoleic acid metabolism_Homo sapiens_hsa005912.10502298
17Amphetamine addiction_Homo sapiens_hsa050312.09703315
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08442893
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02747252
20Maturity onset diabetes of the young_Homo sapiens_hsa049502.00829565
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91425836
22Fanconi anemia pathway_Homo sapiens_hsa034601.87114657
23Glycerolipid metabolism_Homo sapiens_hsa005611.86127651
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.79879320
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77081721
26Protein export_Homo sapiens_hsa030601.76155464
27Selenocompound metabolism_Homo sapiens_hsa004501.72404009
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70619312
29Homologous recombination_Homo sapiens_hsa034401.68566873
30Pentose phosphate pathway_Homo sapiens_hsa000301.65740577
31Renin secretion_Homo sapiens_hsa049241.64128333
32Oxidative phosphorylation_Homo sapiens_hsa001901.58864335
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57818458
34Huntingtons disease_Homo sapiens_hsa050161.57771591
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54385471
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52960739
37Long-term potentiation_Homo sapiens_hsa047201.49570239
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.46243830
39PPAR signaling pathway_Homo sapiens_hsa033201.45024223
40Regulation of autophagy_Homo sapiens_hsa041401.43132429
41mRNA surveillance pathway_Homo sapiens_hsa030151.42549138
42Mineral absorption_Homo sapiens_hsa049781.32434982
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.30464987
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.29651647
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26155686
46Tryptophan metabolism_Homo sapiens_hsa003801.25122810
47Non-homologous end-joining_Homo sapiens_hsa034501.23195335
48Olfactory transduction_Homo sapiens_hsa047401.22666018
49Caffeine metabolism_Homo sapiens_hsa002321.22499230
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22405216
51beta-Alanine metabolism_Homo sapiens_hsa004101.21926878
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21600972
53Insulin secretion_Homo sapiens_hsa049111.16798258
54Cardiac muscle contraction_Homo sapiens_hsa042601.16408413
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16313250
56RNA degradation_Homo sapiens_hsa030181.15700588
57Peroxisome_Homo sapiens_hsa041461.14126974
58Circadian rhythm_Homo sapiens_hsa047101.11412112
59Parkinsons disease_Homo sapiens_hsa050121.10782813
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09933675
61Hedgehog signaling pathway_Homo sapiens_hsa043401.08254648
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06488683
63Asthma_Homo sapiens_hsa053101.05742786
64Ether lipid metabolism_Homo sapiens_hsa005651.03649434
65Estrogen signaling pathway_Homo sapiens_hsa049151.03507320
66Circadian entrainment_Homo sapiens_hsa047131.03009458
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01575902
68RNA transport_Homo sapiens_hsa030131.01436307
69Calcium signaling pathway_Homo sapiens_hsa040201.00696981
70Taste transduction_Homo sapiens_hsa047420.99730945
71Retinol metabolism_Homo sapiens_hsa008300.98071188
72Purine metabolism_Homo sapiens_hsa002300.97273789
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96763359
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95359311
75Fructose and mannose metabolism_Homo sapiens_hsa000510.95164755
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94268194
77Serotonergic synapse_Homo sapiens_hsa047260.92721843
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.91889765
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91835631
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90600232
81Salivary secretion_Homo sapiens_hsa049700.90160128
82Carbon metabolism_Homo sapiens_hsa012000.88490245
83Fat digestion and absorption_Homo sapiens_hsa049750.87639768
84Histidine metabolism_Homo sapiens_hsa003400.87172139
85Thyroid hormone synthesis_Homo sapiens_hsa049180.86814687
86GABAergic synapse_Homo sapiens_hsa047270.82464311
87Gastric acid secretion_Homo sapiens_hsa049710.82129859
88Antigen processing and presentation_Homo sapiens_hsa046120.80157229
89Fatty acid metabolism_Homo sapiens_hsa012120.77611341
90Synaptic vesicle cycle_Homo sapiens_hsa047210.76255837
91cAMP signaling pathway_Homo sapiens_hsa040240.76202411
92Collecting duct acid secretion_Homo sapiens_hsa049660.75779730
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75515382
94Nicotine addiction_Homo sapiens_hsa050330.74077058
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73680380
96Glutamatergic synapse_Homo sapiens_hsa047240.72390885
97Inositol phosphate metabolism_Homo sapiens_hsa005620.72062069
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.69160116
99RNA polymerase_Homo sapiens_hsa030200.68904059
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65412299
101Fatty acid degradation_Homo sapiens_hsa000710.65051675
102Dopaminergic synapse_Homo sapiens_hsa047280.63568729
103Cocaine addiction_Homo sapiens_hsa050300.63227971
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61797120
105Axon guidance_Homo sapiens_hsa043600.59940194
106Alzheimers disease_Homo sapiens_hsa050100.58560480
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57167387
108AMPK signaling pathway_Homo sapiens_hsa041520.56825844
109Bile secretion_Homo sapiens_hsa049760.56745589
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55100807
111Morphine addiction_Homo sapiens_hsa050320.54155191
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.53431897
113Biosynthesis of amino acids_Homo sapiens_hsa012300.53223249
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51365304
115Pancreatic secretion_Homo sapiens_hsa049720.50903181
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.50049619
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50019389
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.50008779
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49476604
120TGF-beta signaling pathway_Homo sapiens_hsa043500.49020382
121Gap junction_Homo sapiens_hsa045400.48077030
122Protein digestion and absorption_Homo sapiens_hsa049740.47987942
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47637962
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.47586032
125Metabolic pathways_Homo sapiens_hsa011000.47446008
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47161659
127Renin-angiotensin system_Homo sapiens_hsa046140.47014178
128Endocytosis_Homo sapiens_hsa041440.45283246
129Wnt signaling pathway_Homo sapiens_hsa043100.44846261
130Cholinergic synapse_Homo sapiens_hsa047250.44142790
131Glutathione metabolism_Homo sapiens_hsa004800.43999720
132ABC transporters_Homo sapiens_hsa020100.43690915
133Phagosome_Homo sapiens_hsa041450.42862373
134Arachidonic acid metabolism_Homo sapiens_hsa005900.41499976
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40892135
136VEGF signaling pathway_Homo sapiens_hsa043700.40190378
137Alcoholism_Homo sapiens_hsa050340.39534342
138Basal cell carcinoma_Homo sapiens_hsa052170.39198442
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38021127
140Oxytocin signaling pathway_Homo sapiens_hsa049210.37650267
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37209409
142Type I diabetes mellitus_Homo sapiens_hsa049400.36787505
143Ovarian steroidogenesis_Homo sapiens_hsa049130.34579724
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30087363
145Cell cycle_Homo sapiens_hsa041100.28718315
146Systemic lupus erythematosus_Homo sapiens_hsa053220.28608663
147Phototransduction_Homo sapiens_hsa047440.25071047
148Chemical carcinogenesis_Homo sapiens_hsa052040.24204091
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22656206
150Tight junction_Homo sapiens_hsa045300.21590133

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